Camptothecin

checkpoint kinase 2 ; Homo sapiens







16 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 35430566 SLFN12 Over-expression Sensitizes Triple Negative Breast Cancer Cells to Chemotherapy Drugs and Radiotherapy. 2022 May-Jun 2
2 33237422 Analyzing Signaling Pathways Using Antibody Arrays. 2021 1
3 29774099 Camptothecin induces G2/M phase arrest through the ATM-Chk2-Cdc25C axis as a result of autophagy-induced cytoprotection: Implications of reactive oxygen species. 2018 Apr 24 3
4 27964702 Minichromosome Maintenance Complex is Required for Checkpoint Kinase 2 Chromatin Loading and its Phosphorylation to DNA Damage Response in SCC-4 Cells. 2017 2
5 26055704 hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ. 2015 Jul 24 1
6 24858802 Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells. 2014 Aug 1 2
7 24912678 RhoB promotes γH2AX dephosphorylation and DNA double-strand break repair. 2014 Aug 1
8 24915421 A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I. 2014 Aug 1 1
9 20042274 ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968. 2010 Jun 28 2
10 19557000 Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. 2009 Aug 2
11 18566216 Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins. 2008 Jun 1
12 16407843 p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine. 2006 May 11 2
13 16905549 Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. 2006 Oct 13 2
14 15699047 The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons. 2005 Apr 8 1
15 16150728 DNA damage regulates Chk2 association with chromatin. 2005 Nov 11 1
16 11557032 Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells. 2001 Sep 7 2