Irinotecan

UDP glucuronosyltransferase family 1 member A9 ; Homo sapiens







22 Article(s)
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1 29076612 New Insights into SN-38 Glucuronidation: Evidence for the Important Role of UDP Glucuronosyltransferase 1A9. 2018 Apr 4
2 27895797 UGT1A1*6, UGT1A7*3 and UGT1A9*1b polymorphisms are predictive markers for severe toxicity in patients with metastatic gastrointestinal cancer treated with irinotecan-based regimens. 2016 Nov 1
3 24897286 Association analysis of UGT1A genotype and haplotype with SN-38 glucuronidation in human livers. 2014 Apr 6
4 23303296 Polymorphisms of the UDP-glucuronosyl transferase 1A genes are associated with adverse events in cancer patients receiving irinotecan-based chemotherapy. 2013 Feb 1
5 23789755 [Influence of genetic polymorphisms in UGT1A1, UGT1A7 and UGT1A9 on the pharmacokynetics of irinotecan, SN-38 and SN-38G]. 2013 Mar-Apr 5
6 24033692 UGT1A1*6, 1A7*3, and 1A9*22 genotypes predict severe neutropenia in FOLFIRI-treated metastatic colorectal cancer in two prospective studies in Japan. 2013 Dec 1
7 21617725 Concurrence of UGT1A polymorphism and end-stage renal disease leads to severe toxicities of irinotecan in a patient with metastatic colon cancer. 2011 Mar-Apr 2
8 18221820 Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer. 2009 Jan 1
9 18981166 Close association of UGT1A9 IVS1+399C>T with UGT1A1*28, *6, or *60 haplotype and its apparent influence on 7-ethyl-10-hydroxycamptothecin (SN-38) glucuronidation in Japanese. 2009 Feb 3
10 17700594 Influence of UGT1A9 intronic I399C>T polymorphism on SN-38 glucuronidation in Asian cancer patients. 2008 Jun 5
11 18418374 Pharmacogenetic pathway analysis of irinotecan. 2008 Sep 6
12 18816295 Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9). 2008 Aug 2
13 17406868 Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer. 2007 Sep 3
14 17608024 UGT1AI*6 and UGT1A1*27 for individualized irinotecan chemotherapy. 2007 Jun 1
15 16595709 The novel UGT1A9 intronic I399 polymorphism appears as a predictor of 7-ethyl-10-hydroxycamptothecin glucuronidation levels in the liver. 2006 Jul 6
16 16636344 Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin. 2006 May 20 2
17 15709193 UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. 2005 Feb 1 2
18 15864130 Haplotypes of variants in the UDP-glucuronosyltransferase1A9 and 1A1 genes. 2005 May 4
19 15286088 Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38. 2004 Aug 6
20 12730278 Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients. 2003 Aug 4
21 12181437 Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). 2002 Sep 4
22 11695848 Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin. 2001 Oct 2