Metformin

mechanistic target of rapamycin kinase ; Homo sapiens







361 Article(s)
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1 34139918 Multidimensional mechanisms of metformin in cancer treatment. 2022 Apr 2
2 34158423 Chemopreventive Effect of Metformin on Gastric Cancer Development. 2022 Mar 15 1
3 34380878 Promise of metformin for preventing age-related cognitive dysfunction. 2022 Mar 1
4 34637881 Antiproliferative effects of metformin in cellular models of pheochromocytoma. 2022 Jan 1 1
5 34714980 Metformin protects against abdominal aortic aneurysm by Atg7-induced autophagy. 2022 Jan 1
6 34753372 Perspectives of metformin use in endometrial cancer and other gynaecological malignancies. 2022 Apr 2
7 35072253 Metformin in selected malignancies in women. 2022 Jan 24 1
8 35158846 Metformin as a Potential Treatment Option for Endometriosis. 2022 Jan 24 1
9 35196199 Treatments targeting autophagy ameliorate the age-related macular degeneration phenotype in mice lacking APOE (apolipoprotein E). 2022 Feb 23 1
10 35326689 In Vivo and In Vitro Enhanced Tumoricidal Effects of Metformin, Active Vitamin D3, and 5-Fluorouracil Triple Therapy against Colon Cancer by Modulating the PI3K/Akt/PTEN/mTOR Network. 2022 Mar 17 1
11 35341775 Metformin alleviates dexamethasone-induced apoptosis by regulating autophagy via AMPK/mTOR/p70S6K in osteoblasts. 2022 Jun 1 5
12 35433698 The Two-Faced Role of Autophagy in Endometrial Cancer. 2022 1
13 35434034 Metformin reverses tamoxifen resistance through the lncRNA GAS5-medicated mTOR pathway in breast cancer. 2022 Mar 3
14 35528246 Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats. 2022 2
15 35610639 Metformin exerts an antitumor effect by inhibiting bladder cancer cell migration and growth, and promoting apoptosis through the PI3K/AKT/mTOR pathway. 2022 May 24 2
16 35625721 Metformin Protects against Diabetic Cardiomyopathy: An Association between Desmin-Sarcomere Injury and the iNOS/mTOR/TIMP-1 Fibrosis Axis. 2022 Apr 23 1
17 32657143 Combination of Curcumin and Metformin Inhibits Cell Growth and Induces Apoptosis without Affecting the Cell Cycle in LNCaP Prostate Cancer Cell Line. 2021 1
18 32951587 The Chemosensitizing Role of Metformin in Anti-Cancer Therapy. 2021 1
19 32994182 Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling. 2021 Jan 3
20 33007330 FGFR1 overexpression renders breast cancer cells resistant to metformin through activation of IRS1/ERK signaling. 2021 Jan 1
21 33141412 Ameliorative Effects of Quercetin and Metformin and Their Combination Against Experimental Endometriosis in Rats. 2021 Mar 1
22 33148437 Targeting ageing and preventing organ degeneration with metformin. 2021 Feb 2
23 33161784 Metformin as a potential therapeutic for neurological disease: mobilizing AMPK to repair the nervous system. 2021 Jan 1
24 33232684 Metformin is Associated with Decreased 30-Day Mortality Among Nursing Home Residents Infected with SARS-CoV2. 2021 Jan 2
25 33262823 Metformin inhibits epithelial-mesenchymal transition of oral squamous cell carcinoma via the mTOR/HIF-1α/PKM2/STAT3 pathway. 2021 Jan 2
26 33365058 Metformin alleviates β-glycerophosphate-induced calcification of vascular smooth muscle cells via AMPK/mTOR-activated autophagy. 2021 Jan 3
27 33439105 Metformin slows liver cyst formation and fibrosis in experimental model of polycystic liver disease. 2021 Apr 1 1
28 33443781 Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus. 2021 Feb 1
29 33509804 The Effect of Metformin in Treatment of Adenomas in Patients with Familial Adenomatous Polyposis. 2021 May 1
30 33524789 The effects of metformin on autophagy. 2021 May 3
31 33575476 Metformin enhances anti-cancer effects of cisplatin in meningioma through AMPK-mTOR signaling pathways. 2021 Mar 26 4
32 33650651 Metformin inhibits mTOR and c-Myc by decreasing YAP protein expression in OSCC cells. 2021 Mar 11
33 33652909 Metformin Increases Survival in Hypopharyngeal Cancer Patients with Diabetes Mellitus: Retrospective Cohort Study and Cell-Based Analysis. 2021 Feb 26 1
34 33689478 The intersection of metformin and inflammation. 2021 May 1 1
35 33690729 Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line. 2021 1
36 33762564 Retracted: Anticancer Activity of Metformin, an Antidiabetic Drug, Against Ovarian Cancer Cells Involves Inhibition of Cysteine-Rich 61 (Cyr61)/Akt/Mammalian Target of Rapamycin (mTOR) Signaling Pathway. 2021 Mar 25 4
37 33807522 Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History. 2021 Mar 5 2
38 33838541 Narrative review of the influence of diabetes mellitus and hyperglycemia on colorectal cancer risk and oncological outcomes. 2021 Jul 1
39 33850550 Metformin attenuates diabetic renal injury via the AMPK-autophagy axis. 2021 Jun 2
40 33850553 Metformin prevents PFKFB3-related aerobic glycolysis from enhancing collagen synthesis in lung fibroblasts by regulating AMPK/mTOR pathway. 2021 Jun 3
41 33886150 Pitavastatin and metformin synergistically activate apoptosis and autophagy in pancreatic cancer cells. 2021 Aug 2
42 33929389 Metformin Attenuates Hypoxia-induced Endothelial Cell Injury by Activating the AMP-Activated Protein Kinase Pathway. 2021 Jun 1 2
43 34004440 Metformin prevents BAFF activation of Erk1/2 from B-cell proliferation and survival by impeding mTOR-PTEN/Akt signaling pathway. 2021 Jul 5
44 34062070 The role of AMPK/mTOR signaling pathway in anticancer activity of metformin. 2021 Aug 31 1
45 34152528 A Phase I clinical trial of dose-escalated metabolic therapy combined with concomitant radiation therapy in high-grade glioma. 2021 Jul 1
46 34154617 Correction to: Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts. 2021 Jun 21 1
47 34218545 A new application of mTOR inhibitor drugs as potential therapeutic agents for COVID-19. 2021 Jul 2 1
48 34255745 Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions. 2021 Sep 8 4
49 34257723 Metformin suppresses breast cancer growth via inhibition of cyclooxygenase-2. 2021 Aug 1
50 34296521 Metformin alleviates oxidative stress-induced senescence of human lens epithelial cells via AMPK activation and autophagic flux restoration. 2021 Sep 1