Protein Name period circadian regulator 2
Organism Homo sapiens
Gene ID 8864
Gene Symbol

PER2

UniProt O15055 (PER2_HUMAN)
Relationships Total Number of functionally related compound(s) : 260
Total Number of Articles : 298
Description

period circadian regulator 2

Gene Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]

synonyms
  • period circadian protein homolog 2
  • circadian clock protein PERIOD 2
  • hPER2
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Properties