| Protein Name | CD38 molecule |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 952 |
| Gene Symbol | CD38 |
| UniProt | P28907 (CD38_HUMAN), B4E006 (B4E006_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
501
Total Number of Articles : 832 |
Description |
CD38 molecule |
| Gene Summary |
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
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| Properties | |