| Protein Name | ryanodine receptor 2 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 689560 |
| Gene Symbol | Ryr2 |
| UniProt | B0LPN4 (RYR2_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
235
Total Number of Articles : 306 |
Description |
ryanodine receptor 2 |
| Gene Summary |
Enables calcium-induced calcium release activity; ryanodine-sensitive calcium-release channel activity; and scaffold protein binding activity. Involved in several processes, including metal ion transport; negative regulation of cytosolic calcium ion concentration; and response to magnesium ion. Located in several cellular components, including A band; sarcolemma; and sarcoplasmic reticulum membrane. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Colocalizes with Z disc. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 2; and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2). [provided by Alliance of Genome Resources, Apr 2022] |
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| Properties | |