PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2849100-1	1988	The amino-terminal amino acid sequence and several internal peptide sequences of angiotensin I-converting enzyme (ACE; peptidyl-dipeptidase A, kininase II; EC 3.4.15.1) purified from human kidney were used to design oligonucleotide probes.	Oligonucleotides	216-231	angiotensin converting enzyme 2	Homo sapiens	119-141
33840836-10	2021	Our docking results indicate that the compounds ZINC12562757 and 112260215 were the best potential inhibitors of the ACE2 and MPro, respectively.	ZINC12562757	48-60	angiotensin converting enzyme 2	Homo sapiens	117-121
3027262-1	1987	The electric organ of Torpedo marmorata contains a membrane-bound, captopril-sensitive metallopeptidase that resembles mammalian angiotensin converting enzyme (peptidyl dipeptidase A; EC 3.4.15.1).	Captopril	67-76	angiotensin converting enzyme 2	Homo sapiens	160-182
34007088-7	2021	Results of the binding free energy from the in-silico analysis, showed that three compounds (7i, 7k and 8f) and six compounds (7b, 7h, 7k, 8d, 8g, and 8h) showed higher and better binding high affinity to SARS-CoV-2 Sgp and hACE-2, respectively compared to the standard drugs cefoperazone (CFZ) and MLN-4760.	Cefoperazone	276-288	angiotensin converting enzyme 2	Homo sapiens	224-230
34007088-7	2021	Results of the binding free energy from the in-silico analysis, showed that three compounds (7i, 7k and 8f) and six compounds (7b, 7h, 7k, 8d, 8g, and 8h) showed higher and better binding high affinity to SARS-CoV-2 Sgp and hACE-2, respectively compared to the standard drugs cefoperazone (CFZ) and MLN-4760.	Cefoperazone	290-293	angiotensin converting enzyme 2	Homo sapiens	224-230
33831468-15	2021	The molecular docking showed that Rutin, Liquiritin and Astragaloside IV had a good affinity with COVID-19 3CL hydrolytic enzyme and ACE2.	liquiritin	41-51	angiotensin converting enzyme 2	Homo sapiens	133-137
34054222-4	2021	Key findings and conclusions: EGCG, via activating Nrf2, can suppress ACE2 (a cellular receptor for SARS-CoV-2) and TMPRSS2, which mediate cell entry of the virus.	epigallocatechin gallate	30-34	angiotensin converting enzyme 2	Homo sapiens	70-74
33967344-8	2021	In addition, Usnic acid revealed its ability to combat the interaction of RBD of SGP to angiotensin-converting enzyme-2 in docking analysis.	usnic acid	13-23	angiotensin converting enzyme 2	Homo sapiens	88-119
33852951-3	2021	The recombinant hACE2 (rhACE2) was purified by affinity chromatography on a Ni-NTA column and characterized with SDS-PAGE and Western blot.	ni-nta	76-82	angiotensin converting enzyme 2	Homo sapiens	16-21
33852951-3	2021	The recombinant hACE2 (rhACE2) was purified by affinity chromatography on a Ni-NTA column and characterized with SDS-PAGE and Western blot.	Sodium Dodecyl Sulfate	113-116	angiotensin converting enzyme 2	Homo sapiens	16-21
33831468-15	2021	The molecular docking showed that Rutin, Liquiritin and Astragaloside IV had a good affinity with COVID-19 3CL hydrolytic enzyme and ACE2.	astragaloside	56-69	angiotensin converting enzyme 2	Homo sapiens	133-137
33857754-3	2021	In this study, an electrochemical impedance spectroscopy-based biosensing platform consisting of a recombinant ACE2-coated palladium nano-thin-film electrode as the core sensing element was fabricated for the screening of potential inhibitors against S-protein-ACE2 binding.	Palladium	123-132	angiotensin converting enzyme 2	Homo sapiens	111-115
33857754-3	2021	In this study, an electrochemical impedance spectroscopy-based biosensing platform consisting of a recombinant ACE2-coated palladium nano-thin-film electrode as the core sensing element was fabricated for the screening of potential inhibitors against S-protein-ACE2 binding.	Palladium	123-132	angiotensin converting enzyme 2	Homo sapiens	261-265
33619758-5	2021	Stronger inhibition by tetracycline is verified with nonequilibrium PMF calculations, for which the tetracycline-RBD complex exhibits the lowest free energy profile along the dissociation pathway from ACE2.	Tetracycline	23-35	angiotensin converting enzyme 2	Homo sapiens	201-205
33619758-5	2021	Stronger inhibition by tetracycline is verified with nonequilibrium PMF calculations, for which the tetracycline-RBD complex exhibits the lowest free energy profile along the dissociation pathway from ACE2.	Tetracycline	100-112	angiotensin converting enzyme 2	Homo sapiens	201-205
33619758-5	2021	Stronger inhibition by tetracycline is verified with nonequilibrium PMF calculations, for which the tetracycline-RBD complex exhibits the lowest free energy profile along the dissociation pathway from ACE2.	rbd	113-116	angiotensin converting enzyme 2	Homo sapiens	201-205
33619758-7	2021	These RBD residues also engage in significant hydrogen bonding with the human receptor ACE2.	Hydrogen	46-54	angiotensin converting enzyme 2	Homo sapiens	87-91
33872570-5	2021	Because mechanisms that regulate ACE2 expression in the intestine are poorly understood and there is a need of anti-SARS-CoV-2 therapies, we have settled to investigate whether natural flavonoids might regulate the expression of Ace2 in intestinal models of inflammation.	Flavonoids	185-195	angiotensin converting enzyme 2	Homo sapiens	229-233
33872570-10	2021	In vitro studies demonstrated that pelargonidin significantly reduces the binding of SARS-CoV-2 Spike protein to ACE2 and reduces the SARS-CoV-2 replication in a concentration-dependent manner.	pelargonidin	35-47	angiotensin converting enzyme 2	Homo sapiens	113-117
33872570-11	2021	In summary, we have provided evidence that a natural flavonoid might hold potential in reducing intestinal inflammation and ACE2 Induction in the inflamed colon in a AhR-dependent manner.	Flavonoids	53-62	angiotensin converting enzyme 2	Homo sapiens	124-128
32345140-4	2021	The current study aimed to repurpose stilbenoid analogs, reported for some other biological activities, against SARS-CoV-2 spike protein and human ACE2 receptor complex for their affinity and stability using molecular dynamics simulation and binding free energy analysis based on molecular docking.	Stilbenes	37-47	angiotensin converting enzyme 2	Homo sapiens	147-151
34057870-6	2021	Hence, regulatory effects of metformin on membranous ACE2, and DPP4 can modulate immune reaction against Sars-cov2.	Metformin	29-38	angiotensin converting enzyme 2	Homo sapiens	53-57
32362217-1	2021	The objective of this present study is to focus on the in silico study to screen for an alternative drug that can block the activity of the angiotensin converting enzyme 2 (ACE2) as a receptor for SARS-CoV-2, potential therapeutic target of the COVID-19 virus using natural compounds (Isothymol, Thymol, Limonene, P-cymene and gamma-terpinene) derived from the essential oil of the antiviral and antimicrobial plant Ammoides verticillata (Desf.)	Thymol	296-302	angiotensin converting enzyme 2	Homo sapiens	140-171
32345140-7	2021	However, fifty nanoseconds molecular dynamic simulation in aqueous solution revealed highly stable bound conformation of resveratrol to the viral protein: ACE2 receptor complex.	Resveratrol	121-132	angiotensin converting enzyme 2	Homo sapiens	155-159
32362217-1	2021	The objective of this present study is to focus on the in silico study to screen for an alternative drug that can block the activity of the angiotensin converting enzyme 2 (ACE2) as a receptor for SARS-CoV-2, potential therapeutic target of the COVID-19 virus using natural compounds (Isothymol, Thymol, Limonene, P-cymene and gamma-terpinene) derived from the essential oil of the antiviral and antimicrobial plant Ammoides verticillata (Desf.)	Thymol	296-302	angiotensin converting enzyme 2	Homo sapiens	173-177
32345140-11	2021	[Formula: see text] Communicated by Ramaswamy H. SarmaHighlightsStilbenoid analogs could be potential disruptors of SARS-CoV-2 spike protein and human ACE2 receptor complex.In particular, resveratrol revealed highly stable conformation to the viral protein: ACE2 receptor complex.The strong interaction of resveratrol is affirmed by molecular dynamic simulation studies and better net free energies.	sarmahighlightsstilbenoid	49-74	angiotensin converting enzyme 2	Homo sapiens	151-155
32362217-1	2021	The objective of this present study is to focus on the in silico study to screen for an alternative drug that can block the activity of the angiotensin converting enzyme 2 (ACE2) as a receptor for SARS-CoV-2, potential therapeutic target of the COVID-19 virus using natural compounds (Isothymol, Thymol, Limonene, P-cymene and gamma-terpinene) derived from the essential oil of the antiviral and antimicrobial plant Ammoides verticillata (Desf.)	Limonene	304-312	angiotensin converting enzyme 2	Homo sapiens	140-171
32362217-1	2021	The objective of this present study is to focus on the in silico study to screen for an alternative drug that can block the activity of the angiotensin converting enzyme 2 (ACE2) as a receptor for SARS-CoV-2, potential therapeutic target of the COVID-19 virus using natural compounds (Isothymol, Thymol, Limonene, P-cymene and gamma-terpinene) derived from the essential oil of the antiviral and antimicrobial plant Ammoides verticillata (Desf.)	Limonene	304-312	angiotensin converting enzyme 2	Homo sapiens	173-177
32362217-1	2021	The objective of this present study is to focus on the in silico study to screen for an alternative drug that can block the activity of the angiotensin converting enzyme 2 (ACE2) as a receptor for SARS-CoV-2, potential therapeutic target of the COVID-19 virus using natural compounds (Isothymol, Thymol, Limonene, P-cymene and gamma-terpinene) derived from the essential oil of the antiviral and antimicrobial plant Ammoides verticillata (Desf.)	4-cymene	314-322	angiotensin converting enzyme 2	Homo sapiens	140-171
32362217-1	2021	The objective of this present study is to focus on the in silico study to screen for an alternative drug that can block the activity of the angiotensin converting enzyme 2 (ACE2) as a receptor for SARS-CoV-2, potential therapeutic target of the COVID-19 virus using natural compounds (Isothymol, Thymol, Limonene, P-cymene and gamma-terpinene) derived from the essential oil of the antiviral and antimicrobial plant Ammoides verticillata (Desf.)	4-cymene	314-322	angiotensin converting enzyme 2	Homo sapiens	173-177
32362217-1	2021	The objective of this present study is to focus on the in silico study to screen for an alternative drug that can block the activity of the angiotensin converting enzyme 2 (ACE2) as a receptor for SARS-CoV-2, potential therapeutic target of the COVID-19 virus using natural compounds (Isothymol, Thymol, Limonene, P-cymene and gamma-terpinene) derived from the essential oil of the antiviral and antimicrobial plant Ammoides verticillata (Desf.)	gamma-terpinene	327-342	angiotensin converting enzyme 2	Homo sapiens	140-171
32362217-1	2021	The objective of this present study is to focus on the in silico study to screen for an alternative drug that can block the activity of the angiotensin converting enzyme 2 (ACE2) as a receptor for SARS-CoV-2, potential therapeutic target of the COVID-19 virus using natural compounds (Isothymol, Thymol, Limonene, P-cymene and gamma-terpinene) derived from the essential oil of the antiviral and antimicrobial plant Ammoides verticillata (Desf.)	gamma-terpinene	327-342	angiotensin converting enzyme 2	Homo sapiens	173-177
32362217-4	2021	This study reveals that Isothymol, a major component of this plant, gives the best docking scores, compared to, the co-crystallized inhibitor beta-D-mannose of the enzyme ACE2, to Captropil drug as good ACE2 inhibitor and to Chloroquine antiviral drug also involved in other mechanisms as inhibition of ACE2 cellular receptor.	carvacrol	24-33	angiotensin converting enzyme 2	Homo sapiens	171-175
32362217-4	2021	This study reveals that Isothymol, a major component of this plant, gives the best docking scores, compared to, the co-crystallized inhibitor beta-D-mannose of the enzyme ACE2, to Captropil drug as good ACE2 inhibitor and to Chloroquine antiviral drug also involved in other mechanisms as inhibition of ACE2 cellular receptor.	carvacrol	24-33	angiotensin converting enzyme 2	Homo sapiens	203-207
32345140-11	2021	[Formula: see text] Communicated by Ramaswamy H. SarmaHighlightsStilbenoid analogs could be potential disruptors of SARS-CoV-2 spike protein and human ACE2 receptor complex.In particular, resveratrol revealed highly stable conformation to the viral protein: ACE2 receptor complex.The strong interaction of resveratrol is affirmed by molecular dynamic simulation studies and better net free energies.	sarmahighlightsstilbenoid	49-74	angiotensin converting enzyme 2	Homo sapiens	258-262
32362217-4	2021	This study reveals that Isothymol, a major component of this plant, gives the best docking scores, compared to, the co-crystallized inhibitor beta-D-mannose of the enzyme ACE2, to Captropil drug as good ACE2 inhibitor and to Chloroquine antiviral drug also involved in other mechanisms as inhibition of ACE2 cellular receptor.	carvacrol	24-33	angiotensin converting enzyme 2	Homo sapiens	203-207
32345140-11	2021	[Formula: see text] Communicated by Ramaswamy H. SarmaHighlightsStilbenoid analogs could be potential disruptors of SARS-CoV-2 spike protein and human ACE2 receptor complex.In particular, resveratrol revealed highly stable conformation to the viral protein: ACE2 receptor complex.The strong interaction of resveratrol is affirmed by molecular dynamic simulation studies and better net free energies.	Resveratrol	188-199	angiotensin converting enzyme 2	Homo sapiens	151-155
32345140-11	2021	[Formula: see text] Communicated by Ramaswamy H. SarmaHighlightsStilbenoid analogs could be potential disruptors of SARS-CoV-2 spike protein and human ACE2 receptor complex.In particular, resveratrol revealed highly stable conformation to the viral protein: ACE2 receptor complex.The strong interaction of resveratrol is affirmed by molecular dynamic simulation studies and better net free energies.	Resveratrol	188-199	angiotensin converting enzyme 2	Homo sapiens	258-262
32362217-1	2021	The objective of this present study is to focus on the in silico study to screen for an alternative drug that can block the activity of the angiotensin converting enzyme 2 (ACE2) as a receptor for SARS-CoV-2, potential therapeutic target of the COVID-19 virus using natural compounds (Isothymol, Thymol, Limonene, P-cymene and gamma-terpinene) derived from the essential oil of the antiviral and antimicrobial plant Ammoides verticillata (Desf.)	carvacrol	285-294	angiotensin converting enzyme 2	Homo sapiens	140-171
32362217-4	2021	This study reveals that Isothymol, a major component of this plant, gives the best docking scores, compared to, the co-crystallized inhibitor beta-D-mannose of the enzyme ACE2, to Captropil drug as good ACE2 inhibitor and to Chloroquine antiviral drug also involved in other mechanisms as inhibition of ACE2 cellular receptor.	beta-1,4-mannan	142-156	angiotensin converting enzyme 2	Homo sapiens	171-175
32362217-4	2021	This study reveals that Isothymol, a major component of this plant, gives the best docking scores, compared to, the co-crystallized inhibitor beta-D-mannose of the enzyme ACE2, to Captropil drug as good ACE2 inhibitor and to Chloroquine antiviral drug also involved in other mechanisms as inhibition of ACE2 cellular receptor.	beta-1,4-mannan	142-156	angiotensin converting enzyme 2	Homo sapiens	203-207
32362217-4	2021	This study reveals that Isothymol, a major component of this plant, gives the best docking scores, compared to, the co-crystallized inhibitor beta-D-mannose of the enzyme ACE2, to Captropil drug as good ACE2 inhibitor and to Chloroquine antiviral drug also involved in other mechanisms as inhibition of ACE2 cellular receptor.	beta-1,4-mannan	142-156	angiotensin converting enzyme 2	Homo sapiens	203-207
32362217-1	2021	The objective of this present study is to focus on the in silico study to screen for an alternative drug that can block the activity of the angiotensin converting enzyme 2 (ACE2) as a receptor for SARS-CoV-2, potential therapeutic target of the COVID-19 virus using natural compounds (Isothymol, Thymol, Limonene, P-cymene and gamma-terpinene) derived from the essential oil of the antiviral and antimicrobial plant Ammoides verticillata (Desf.)	carvacrol	285-294	angiotensin converting enzyme 2	Homo sapiens	173-177
32362217-4	2021	This study reveals that Isothymol, a major component of this plant, gives the best docking scores, compared to, the co-crystallized inhibitor beta-D-mannose of the enzyme ACE2, to Captropil drug as good ACE2 inhibitor and to Chloroquine antiviral drug also involved in other mechanisms as inhibition of ACE2 cellular receptor.	captropil	180-189	angiotensin converting enzyme 2	Homo sapiens	171-175
33861415-0	2021	beta-elemene affects angiogenesis of infantile hemangioma by regulating angiotensin-converting enzyme 2 and hypoxia-inducible factor-1 alpha.	beta-elemene	0-12	angiotensin converting enzyme 2	Homo sapiens	72-103
32362217-4	2021	This study reveals that Isothymol, a major component of this plant, gives the best docking scores, compared to, the co-crystallized inhibitor beta-D-mannose of the enzyme ACE2, to Captropil drug as good ACE2 inhibitor and to Chloroquine antiviral drug also involved in other mechanisms as inhibition of ACE2 cellular receptor.	captropil	180-189	angiotensin converting enzyme 2	Homo sapiens	203-207
32362217-4	2021	This study reveals that Isothymol, a major component of this plant, gives the best docking scores, compared to, the co-crystallized inhibitor beta-D-mannose of the enzyme ACE2, to Captropil drug as good ACE2 inhibitor and to Chloroquine antiviral drug also involved in other mechanisms as inhibition of ACE2 cellular receptor.	captropil	180-189	angiotensin converting enzyme 2	Homo sapiens	203-207
32362217-4	2021	This study reveals that Isothymol, a major component of this plant, gives the best docking scores, compared to, the co-crystallized inhibitor beta-D-mannose of the enzyme ACE2, to Captropil drug as good ACE2 inhibitor and to Chloroquine antiviral drug also involved in other mechanisms as inhibition of ACE2 cellular receptor.	Chloroquine	225-236	angiotensin converting enzyme 2	Homo sapiens	171-175
32362217-8	2021	This study revealed for the first time that Isothymol is a functional inhibitor of angiotensin converting enzyme 2 activity and the components of essential oils Ammoides verticillata can be used as potential inhibitors to the ACE2 receptor of SARS-CoV-2.Communicated by Ramaswamy H. Sarma.	carvacrol	44-53	angiotensin converting enzyme 2	Homo sapiens	83-114
32362217-8	2021	This study revealed for the first time that Isothymol is a functional inhibitor of angiotensin converting enzyme 2 activity and the components of essential oils Ammoides verticillata can be used as potential inhibitors to the ACE2 receptor of SARS-CoV-2.Communicated by Ramaswamy H. Sarma.	carvacrol	44-53	angiotensin converting enzyme 2	Homo sapiens	226-230
32362217-8	2021	This study revealed for the first time that Isothymol is a functional inhibitor of angiotensin converting enzyme 2 activity and the components of essential oils Ammoides verticillata can be used as potential inhibitors to the ACE2 receptor of SARS-CoV-2.Communicated by Ramaswamy H. Sarma.	Oils, Volatile	146-160	angiotensin converting enzyme 2	Homo sapiens	226-230
33861415-7	2021	ACE2 expression was down-regulated with the treatment of beta-elemene at different dosage point.	beta-elemene	57-69	angiotensin converting enzyme 2	Homo sapiens	0-4
33861415-10	2021	Taken together, our data indicated that the different effects of beta-elemene on the proliferation, migration and angiogenesis of hemangioma at different concentrations: The ACE2 signaling pathway dominates with treatment of low concentrations of beta-elemene, stimulating the expression of downstream VEGFA to promote the angiogenesis of hemangioma; under the condition of high concentrations of beta-elemene, the HIF-1-alpha signaling pathway inhibits the expression of VEGFA and further inhibits the angiogenesis of hemangioma.	beta-elemene	65-77	angiotensin converting enzyme 2	Homo sapiens	174-178
33861415-10	2021	Taken together, our data indicated that the different effects of beta-elemene on the proliferation, migration and angiogenesis of hemangioma at different concentrations: The ACE2 signaling pathway dominates with treatment of low concentrations of beta-elemene, stimulating the expression of downstream VEGFA to promote the angiogenesis of hemangioma; under the condition of high concentrations of beta-elemene, the HIF-1-alpha signaling pathway inhibits the expression of VEGFA and further inhibits the angiogenesis of hemangioma.	beta-elemene	247-259	angiotensin converting enzyme 2	Homo sapiens	174-178
33861415-10	2021	Taken together, our data indicated that the different effects of beta-elemene on the proliferation, migration and angiogenesis of hemangioma at different concentrations: The ACE2 signaling pathway dominates with treatment of low concentrations of beta-elemene, stimulating the expression of downstream VEGFA to promote the angiogenesis of hemangioma; under the condition of high concentrations of beta-elemene, the HIF-1-alpha signaling pathway inhibits the expression of VEGFA and further inhibits the angiogenesis of hemangioma.	beta-elemene	247-259	angiotensin converting enzyme 2	Homo sapiens	174-178
34059790-0	2021	Fludarabine inhibits type I interferon-induced expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2.	fludarabine	0-11	angiotensin converting enzyme 2	Homo sapiens	85-116
33746069-5	2021	Here, nigellidine, an indazole-alkaloid was analyzed by molecular-docking for binding to different Angiotensin-binding-proteins (enzymes, ACE1(6en5)/ACE2(4aph)/receptors, AT1(6os1)/AT2(5xjm)) and COVID-19 spike-glycoprotein(6vsb).	Nigellidine	6-17	angiotensin converting enzyme 2	Homo sapiens	149-153
33746069-6	2021	Nigellidine strongly binds to the spike-protein at the hinge-region/active-site-opening which may hamper proper-binding of nCoV2-ACE2 surface.	Nigellidine	0-11	angiotensin converting enzyme 2	Homo sapiens	129-133
33746069-7	2021	Nigellidine effectively binds in the Angiotensin- II binding-site/entry-pocket (-7.54 kcal/mol, -211.76, Atomic-Contact-Energy; ACE-value) of ACE2 (Ki 8.68 and 8.3 mumol) in comparison to known-binder EGCG (-4.53) and Theaflavin-di-gallate (-2.85).	Nigellidine	0-11	angiotensin converting enzyme 2	Homo sapiens	142-146
33746069-7	2021	Nigellidine effectively binds in the Angiotensin- II binding-site/entry-pocket (-7.54 kcal/mol, -211.76, Atomic-Contact-Energy; ACE-value) of ACE2 (Ki 8.68 and 8.3 mumol) in comparison to known-binder EGCG (-4.53) and Theaflavin-di-gallate (-2.85).	epigallocatechin gallate	201-205	angiotensin converting enzyme 2	Homo sapiens	142-146
33681755-4	2021	Here, using Molecular Dynamics simulations (MD) and Monte Carlo (MC) sampling, we show that the N501 mutation enhanced the electrostatic interactions due to the formation of a strong hydrogen bond between SARS-CoV-2-T500 and ACE2-D355 near the mutation site.	Hydrogen	183-191	angiotensin converting enzyme 2	Homo sapiens	225-229
33746069-7	2021	Nigellidine effectively binds in the Angiotensin- II binding-site/entry-pocket (-7.54 kcal/mol, -211.76, Atomic-Contact-Energy; ACE-value) of ACE2 (Ki 8.68 and 8.3 mumol) in comparison to known-binder EGCG (-4.53) and Theaflavin-di-gallate (-2.85).	theaflavin digallate	218-239	angiotensin converting enzyme 2	Homo sapiens	142-146
33746069-13	2021	Angiotensin II-ACE2 binding (ACE-value -294.81) is more favorable than nigellidine-ACE2.	Nigellidine	71-82	angiotensin converting enzyme 2	Homo sapiens	83-87
33746069-14	2021	Conversely, nigellidine-ACE1 binding-energy/Ki is lower than nigellidine-ACE2 values indicating a balanced-state between constriction-dilatation.	Nigellidine	61-72	angiotensin converting enzyme 2	Homo sapiens	73-77
33746069-15	2021	Moreover, nigellidine binds to the viral-spike, closer-proximity to its ACE2 binding-domain.	Nigellidine	10-21	angiotensin converting enzyme 2	Homo sapiens	72-76
33999630-7	2021	Microsecond time scale LiGaMD simulations have unprecedentedly captured multiple times of spontaneous binding and unbinding of a potent inhibitor MLN-4760 in the ACE2 receptor.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	146-154	angiotensin converting enzyme 2	Homo sapiens	162-166
34051791-6	2021	ACE2 was further increased in frequent exacerbators compared to infrequent exacerbators (0.51, p = 0.00045) and associated with use of ACE inhibitors (ACEi) (0.50, p = 0.0034), having cardiovascular disease (0.23, p = 0.048) or hypertension (0.34, p = 0.0089), and inhaled corticosteroid use in COPD subjects in bronchial biopsies (0.33, p = 0.049).	inhibitors	139-149	angiotensin converting enzyme 2	Homo sapiens	0-4
34056140-7	2021	Three flavonoids parvisoflavone B (3), alpinumisoflavone (5) and norisojamicin (2) were effective in blocking the viral entry by binding strongly at the spike RBD-ACE2 interface with the inhibition constant of 0.56, 0.78 and 0.93 muM, respectively.	Flavonoids	6-16	angiotensin converting enzyme 2	Homo sapiens	163-167
34056140-7	2021	Three flavonoids parvisoflavone B (3), alpinumisoflavone (5) and norisojamicin (2) were effective in blocking the viral entry by binding strongly at the spike RBD-ACE2 interface with the inhibition constant of 0.56, 0.78 and 0.93 muM, respectively.	Parvisoflavone B	17-33	angiotensin converting enzyme 2	Homo sapiens	163-167
34056140-7	2021	Three flavonoids parvisoflavone B (3), alpinumisoflavone (5) and norisojamicin (2) were effective in blocking the viral entry by binding strongly at the spike RBD-ACE2 interface with the inhibition constant of 0.56, 0.78 and 0.93 muM, respectively.	alpinumisoflavone	39-56	angiotensin converting enzyme 2	Homo sapiens	163-167
34056140-7	2021	Three flavonoids parvisoflavone B (3), alpinumisoflavone (5) and norisojamicin (2) were effective in blocking the viral entry by binding strongly at the spike RBD-ACE2 interface with the inhibition constant of 0.56, 0.78 and 0.93 muM, respectively.	norisojamicin	65-78	angiotensin converting enzyme 2	Homo sapiens	163-167
34052578-0	2021	Azelastine inhibits viropexis of SARS-CoV-2 spike pseudovirus by binding to SARS-CoV-2 entry receptor ACE2.	azelastine	0-10	angiotensin converting enzyme 2	Homo sapiens	102-106
34031383-4	2021	LSD1 colocalized with ACE2 at the cell surface to maintain demethylated SARS-CoV-2 spike receptor-binding domain lysine 31 to promote virus-ACE2 interactions.	Lysine	113-119	angiotensin converting enzyme 2	Homo sapiens	22-26
34052578-4	2021	Here, we discovered antihistamine azelastine has an affinity to ACE2 by cell membrane chromatography (CMC); Then we determined the equilibrium dissociation constant (KD) of azelastine-ACE2 as (2.58 +- 0.48) x 10-7 M by surface plasmon resonance (SPR).	azelastine	34-44	angiotensin converting enzyme 2	Homo sapiens	64-68
34052578-4	2021	Here, we discovered antihistamine azelastine has an affinity to ACE2 by cell membrane chromatography (CMC); Then we determined the equilibrium dissociation constant (KD) of azelastine-ACE2 as (2.58 +- 0.48) x 10-7 M by surface plasmon resonance (SPR).	azelastine	34-44	angiotensin converting enzyme 2	Homo sapiens	184-188
34052578-4	2021	Here, we discovered antihistamine azelastine has an affinity to ACE2 by cell membrane chromatography (CMC); Then we determined the equilibrium dissociation constant (KD) of azelastine-ACE2 as (2.58 +- 0.48) x 10-7 M by surface plasmon resonance (SPR).	azelastine	173-183	angiotensin converting enzyme 2	Homo sapiens	64-68
34052578-4	2021	Here, we discovered antihistamine azelastine has an affinity to ACE2 by cell membrane chromatography (CMC); Then we determined the equilibrium dissociation constant (KD) of azelastine-ACE2 as (2.58 +- 0.48) x 10-7 M by surface plasmon resonance (SPR).	azelastine	173-183	angiotensin converting enzyme 2	Homo sapiens	184-188
34049205-4	2021	Additionally, the cell-surface Glucose Regulated Protein 78 (CS-GRP78) associated with the ACE2-SARS-CoV-2 spike RBD complex (ACE2-S RBD) is modeled at the presence of these mutant variants of the viral spike.	Glucose	31-38	angiotensin converting enzyme 2	Homo sapiens	91-95
34019602-1	2021	We report a distinct difference in the interactions of the glycans of the host-cell receptor, ACE2, with SARS-CoV-2 and SARS-CoV S-protein receptor-binding domains (RBDs).	Polysaccharides	59-66	angiotensin converting enzyme 2	Homo sapiens	94-98
34019602-3	2021	The interactions of the ACE2 glycan at N322 with SARS-CoV RBD are blocked by the presence of the RBD glycan at N357 of the SARS-CoV RBD.	Polysaccharides	29-35	angiotensin converting enzyme 2	Homo sapiens	24-28
34016183-8	2021	Previous studies have shown that people with ACE2 polymorphism who have type 2 transmembrane serine proteases (TMPRSS2) are at high risk of SARS-CoV-2 infection.	Serine	93-99	angiotensin converting enzyme 2	Homo sapiens	45-49
34049205-4	2021	Additionally, the cell-surface Glucose Regulated Protein 78 (CS-GRP78) associated with the ACE2-SARS-CoV-2 spike RBD complex (ACE2-S RBD) is modeled at the presence of these mutant variants of the viral spike.	Glucose	31-38	angiotensin converting enzyme 2	Homo sapiens	126-130
33937725-5	2021	Neutralization mechanism of these antibodies involves receptors other than the canonical hACE2 on target cells, relying both on amino-acid and N-glycan epitope-recognition, suggesting alternative viral cellular-portals.	n-glycan	143-151	angiotensin converting enzyme 2	Homo sapiens	89-94
34010445-4	2021	The binding of SARS-CoV-2 to ACE2 leads to the down-regulation of this enzyme and, in the aftermath, to the excess of angiotensin II and aldosterone.	Aldosterone	137-148	angiotensin converting enzyme 2	Homo sapiens	29-33
34013346-6	2021	According to the result of MM-PBSA binding free energy calculations, we found that V367F and N354D/D364Y mutant types showed enhanced binding affinities with hACE2 compared to the prototype.	poly(tetramethylene succinate-co-tetramethylene adipate)	30-34	angiotensin converting enzyme 2	Homo sapiens	158-163
34006835-0	2021	Ceftazidime is a potential drug to inhibit SARS-CoV-2 infection in vitro by blocking spike protein-ACE2 interaction.	Ceftazidime	0-11	angiotensin converting enzyme 2	Homo sapiens	99-103
33900725-3	2021	Using alanine scanning and mutational sensitivity analysis, we have shown that K417, E484, and N501 residues correspond to key interacting centers with a significant degree of structural and energetic plasticity that allow mutants in these positions to afford the improved binding affinity with ACE2.	Alanine	6-13	angiotensin converting enzyme 2	Homo sapiens	295-299
33900725-3	2021	Using alanine scanning and mutational sensitivity analysis, we have shown that K417, E484, and N501 residues correspond to key interacting centers with a significant degree of structural and energetic plasticity that allow mutants in these positions to afford the improved binding affinity with ACE2.	k417	79-83	angiotensin converting enzyme 2	Homo sapiens	295-299
33900725-3	2021	Using alanine scanning and mutational sensitivity analysis, we have shown that K417, E484, and N501 residues correspond to key interacting centers with a significant degree of structural and energetic plasticity that allow mutants in these positions to afford the improved binding affinity with ACE2.	Methyl 2-oxoindoline-6-carboxylate	95-99	angiotensin converting enzyme 2	Homo sapiens	295-299
34010445-3	2021	Firstly, the virus SARS-CoV-2 responsible for the Covid-19 infection uses an important renin-angiotensin system element - angiotensin-converting enzyme 2 (ACE2) - as a receptor protein for the entry into target cells and, in consequence, disturbs the function of the main (circulating) renin-angiotensin-aldosterone system (RAAS) and of the local renin-angiotensin system (RAS) localized in different tissues and organs.	Aldosterone	304-315	angiotensin converting enzyme 2	Homo sapiens	155-159
33583954-2	2021	The results of molecular docking positioned four molecules at the interaction site Tyr-491(Spike)-Glu-37(ACE2) and one at the site Gly-488(Spike)-Lys-353(ACE2).	Lysine	146-149	angiotensin converting enzyme 2	Homo sapiens	154-158
33987897-0	2021	Influence of daily aspirin therapy on ACE2 expression and function - implications for SARS-CoV2 and patients with aspirin-exacerbated respiratory disease.	Aspirin	19-26	angiotensin converting enzyme 2	Homo sapiens	38-42
33318880-0	2021	Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2.	protoporphyrin IX	0-17	angiotensin converting enzyme 2	Homo sapiens	119-123
33318880-0	2021	Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2.	Verteporfin	22-33	angiotensin converting enzyme 2	Homo sapiens	119-123
33318880-5	2021	Importantly, PpIX and verteporfin prevented SARS-CoV-2 infection in mice adenovirally transduced with human ACE2.	protoporphyrin IX	13-17	angiotensin converting enzyme 2	Homo sapiens	108-112
33318880-5	2021	Importantly, PpIX and verteporfin prevented SARS-CoV-2 infection in mice adenovirally transduced with human ACE2.	Verteporfin	22-33	angiotensin converting enzyme 2	Homo sapiens	108-112
33990955-6	2021	Hence, vitamin D deficiency can exacerbate COVID-19, via its effects on ACE2.	Vitamin D	7-16	angiotensin converting enzyme 2	Homo sapiens	72-76
34035891-2	2021	Renin-angiotensin-aldosterone system (RAAS) blockers enhance the expression of ACE2, the binding receptor of SARS-CoV-2, and can enhance viral infectivity.	Aldosterone	18-29	angiotensin converting enzyme 2	Homo sapiens	79-83
33987897-0	2021	Influence of daily aspirin therapy on ACE2 expression and function - implications for SARS-CoV2 and patients with aspirin-exacerbated respiratory disease.	Aspirin	114-121	angiotensin converting enzyme 2	Homo sapiens	38-42
33979123-4	2021	Among promising candidates identified, several dyes (Congo red, direct violet 1, Evans blue) and novel druglike compounds (DRI-C23041, DRI-C91005) inhibited the interaction of hACE2 with the spike proteins of SARS-CoV-2 as well as SARS-CoV with low micromolar activity in our cell-free ELISA-type assays (IC50"s of 0.2-3.0 muM), whereas control compounds, such as sunset yellow FCF, chloroquine, and suramin, showed no activity.	Congo Red	53-62	angiotensin converting enzyme 2	Homo sapiens	176-181
34013265-8	2021	A local analysis of seven key binding pockets reveals that six out them, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, and protein-glycan interaction sites, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.	Linoleic Acid	135-148	angiotensin converting enzyme 2	Homo sapiens	102-106
34013265-8	2021	A local analysis of seven key binding pockets reveals that six out them, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, and protein-glycan interaction sites, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.	Polysaccharides	197-203	angiotensin converting enzyme 2	Homo sapiens	102-106
33979123-4	2021	Among promising candidates identified, several dyes (Congo red, direct violet 1, Evans blue) and novel druglike compounds (DRI-C23041, DRI-C91005) inhibited the interaction of hACE2 with the spike proteins of SARS-CoV-2 as well as SARS-CoV with low micromolar activity in our cell-free ELISA-type assays (IC50"s of 0.2-3.0 muM), whereas control compounds, such as sunset yellow FCF, chloroquine, and suramin, showed no activity.	Direct Violet 1	64-79	angiotensin converting enzyme 2	Homo sapiens	176-181
34029872-3	2021	Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1.	Silver	6-12	angiotensin converting enzyme 2	Homo sapiens	70-101
34029872-3	2021	Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1.	Silver	6-12	angiotensin converting enzyme 2	Homo sapiens	103-107
33979123-4	2021	Among promising candidates identified, several dyes (Congo red, direct violet 1, Evans blue) and novel druglike compounds (DRI-C23041, DRI-C91005) inhibited the interaction of hACE2 with the spike proteins of SARS-CoV-2 as well as SARS-CoV with low micromolar activity in our cell-free ELISA-type assays (IC50"s of 0.2-3.0 muM), whereas control compounds, such as sunset yellow FCF, chloroquine, and suramin, showed no activity.	Evans Blue	81-91	angiotensin converting enzyme 2	Homo sapiens	176-181
34029872-3	2021	Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1.	Silver	6-12	angiotensin converting enzyme 2	Homo sapiens	145-149
33979123-4	2021	Among promising candidates identified, several dyes (Congo red, direct violet 1, Evans blue) and novel druglike compounds (DRI-C23041, DRI-C91005) inhibited the interaction of hACE2 with the spike proteins of SARS-CoV-2 as well as SARS-CoV with low micromolar activity in our cell-free ELISA-type assays (IC50"s of 0.2-3.0 muM), whereas control compounds, such as sunset yellow FCF, chloroquine, and suramin, showed no activity.	6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt	364-381	angiotensin converting enzyme 2	Homo sapiens	176-181
34029872-3	2021	Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1.	sers	21-25	angiotensin converting enzyme 2	Homo sapiens	70-101
33979123-4	2021	Among promising candidates identified, several dyes (Congo red, direct violet 1, Evans blue) and novel druglike compounds (DRI-C23041, DRI-C91005) inhibited the interaction of hACE2 with the spike proteins of SARS-CoV-2 as well as SARS-CoV with low micromolar activity in our cell-free ELISA-type assays (IC50"s of 0.2-3.0 muM), whereas control compounds, such as sunset yellow FCF, chloroquine, and suramin, showed no activity.	Chloroquine	383-394	angiotensin converting enzyme 2	Homo sapiens	176-181
34029872-3	2021	Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1.	sers	21-25	angiotensin converting enzyme 2	Homo sapiens	103-107
34055688-7	2021	The virus targets the angiotensin converting receptor (ACE receptor), and studies have shown nicotine-based e-cigarettes or vaping cause oxidative stress and resulting in the upregulation of ACE2, which might worsen ARDS in MIS-C. Our mini-review highlights that adolescents using e-cigarette have alterations in their pulmonary defenses against SARS-CoV-2: an upregulation of the ACE2 receptors, the primary target of SARS-CoV-2.	Nicotine	93-101	angiotensin converting enzyme 2	Homo sapiens	191-195
34029872-3	2021	Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1.	sers	21-25	angiotensin converting enzyme 2	Homo sapiens	145-149
33979123-4	2021	Among promising candidates identified, several dyes (Congo red, direct violet 1, Evans blue) and novel druglike compounds (DRI-C23041, DRI-C91005) inhibited the interaction of hACE2 with the spike proteins of SARS-CoV-2 as well as SARS-CoV with low micromolar activity in our cell-free ELISA-type assays (IC50"s of 0.2-3.0 muM), whereas control compounds, such as sunset yellow FCF, chloroquine, and suramin, showed no activity.	Suramin	400-407	angiotensin converting enzyme 2	Homo sapiens	176-181
34029872-3	2021	Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1.	sers	129-133	angiotensin converting enzyme 2	Homo sapiens	70-101
34055688-7	2021	The virus targets the angiotensin converting receptor (ACE receptor), and studies have shown nicotine-based e-cigarettes or vaping cause oxidative stress and resulting in the upregulation of ACE2, which might worsen ARDS in MIS-C. Our mini-review highlights that adolescents using e-cigarette have alterations in their pulmonary defenses against SARS-CoV-2: an upregulation of the ACE2 receptors, the primary target of SARS-CoV-2.	Nicotine	93-101	angiotensin converting enzyme 2	Homo sapiens	381-385
33979123-6	2021	While dyes seemed to be promiscuous inhibitors, DRI-C23041 showed some selectivity and inhibited the entry of two different SARS-CoV-2-S expressing pseudoviruses into hACE2-expressing cells in a concentration-dependent manner with low micromolar IC50"s (6-7 muM).	c23041	52-58	angiotensin converting enzyme 2	Homo sapiens	167-172
34029872-3	2021	Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1.	sers	129-133	angiotensin converting enzyme 2	Homo sapiens	103-107
34029872-3	2021	Using silver-nanorod SERS array functionalized with cellular receptor angiotensin-converting enzyme 2 (ACE2), we obtained strong SERS signals of ACE2 at 1032, 1051, 1089, 1189, 1447 and 1527 cm-1.	sers	129-133	angiotensin converting enzyme 2	Homo sapiens	145-149
33903171-8	2021	By contrast, the glycan at the N322 site interacts tightly with the RBD of the ACE2-bound spike protein and strengthens the complex.	Polysaccharides	17-23	angiotensin converting enzyme 2	Homo sapiens	79-83
33979162-3	2021	By performing all-atom molecular dynamics (MD) simulations, we identified an extended network of salt bridges, hydrophobic and electrostatic interactions, and hydrogen bonds between the receptor-binding domain (RBD) of the S protein and ACE2.	Hydrogen	159-167	angiotensin converting enzyme 2	Homo sapiens	237-241
33964216-2	2021	The aim of this review is to provide a new look at the data already available for COVID-19, exploring it as a transient molecular disease that causes negative regulation of ACE-2 (angiotensin-converting enzyme 2) and, consequently, deregulates the renin-angiotensin-aldosterone system (RAAS), promoting important changes in the microcirculatory environment.	Aldosterone	266-277	angiotensin converting enzyme 2	Homo sapiens	173-178
33979601-8	2021	In turn, pre-treatment of erythroid cells with dexamethasone significantly diminished ACE2/TMPRSS2 expression and subsequently reduced their infectivity with SARS-CoV-2.	Dexamethasone	47-60	angiotensin converting enzyme 2	Homo sapiens	86-90
33972500-0	2021	Lenalidomide downregulates ACE2 protein abundance to alleviate infection by SARS-CoV-2 spike protein conditioned pseudoviruses.	Lenalidomide	0-12	angiotensin converting enzyme 2	Homo sapiens	27-31
33994655-6	2021	The MD simulations of ligand-free, Rutin DAB10-bound, and Swertiapuniside-bound ACE2-Spike complex revealed abrogation of the hydrogen bonding network between the two proteins.	swertiapuniside	58-73	angiotensin converting enzyme 2	Homo sapiens	80-84
33994655-6	2021	The MD simulations of ligand-free, Rutin DAB10-bound, and Swertiapuniside-bound ACE2-Spike complex revealed abrogation of the hydrogen bonding network between the two proteins.	Hydrogen	126-134	angiotensin converting enzyme 2	Homo sapiens	80-84
33962629-14	2021	In vitro exposure of monomeric hACE2 to 120 mM glucose for 12 days led to non-enzymatic glycation of four lysine residues in the neck domain affecting the protein oligomerization.	Glucose	47-54	angiotensin converting enzyme 2	Homo sapiens	31-36
33962629-14	2021	In vitro exposure of monomeric hACE2 to 120 mM glucose for 12 days led to non-enzymatic glycation of four lysine residues in the neck domain affecting the protein oligomerization.	Lysine	106-112	angiotensin converting enzyme 2	Homo sapiens	31-36
33964216-2	2021	The aim of this review is to provide a new look at the data already available for COVID-19, exploring it as a transient molecular disease that causes negative regulation of ACE-2 (angiotensin-converting enzyme 2) and, consequently, deregulates the renin-angiotensin-aldosterone system (RAAS), promoting important changes in the microcirculatory environment.	Aldosterone	266-277	angiotensin converting enzyme 2	Homo sapiens	180-211
33955183-3	2021	Here, we investigated if the angiotensin II type 1 receptor (AT1R) blocker valsartan alters the expression of renin-angiotensin system (RAS) components, including ACE2, in human adipose tissue (AT) and skeletal muscle.	Valsartan	75-84	angiotensin converting enzyme 2	Homo sapiens	163-167
33667455-4	2021	Valproic acid could reduce angiotensin-converting enzyme 2 and transmembrane serine protease 2 expression, required for SARS-CoV-2 viral entry, and modulate the immune cellular and cytokine response to infection, thereby reducing end-organ damage.	Valproic Acid	0-13	angiotensin converting enzyme 2	Homo sapiens	27-58
33951227-4	2021	It was found that the binding of ACE2 to SARS-CoV-2-RBD involved two core regions (31st and 353rd lysine) and 20 amino acids of the ACE2 protein.	Lysine	98-104	angiotensin converting enzyme 2	Homo sapiens	33-37
33135055-7	2021	To deduce the detailed structure of glycan epitopes on hACE2 that may be involved in viral binding, we have characterized the terminal sialic acid linkages, the presence of bisecting GlcNAc, and the pattern of N-glycan fucosylation.	Polysaccharides	36-42	angiotensin converting enzyme 2	Homo sapiens	55-60
34029937-12	2021	BLI assay further confirmed that corilagin exhibits a relatively strong binding affinity to SARS-CoV-2-RBD and hACE2 protein.	corilagin	33-42	angiotensin converting enzyme 2	Homo sapiens	111-116
34029937-13	2021	In addition, corilagin dose-dependently blocks SARS-CoV-2-RBD binding and abolishes the infectious property of RBD-pseudotyped lentivirus in hACE2 overexpressing HEK293 cells, which mimicked the entry of SARS-CoV-2 virus in human host cells.	corilagin	13-22	angiotensin converting enzyme 2	Homo sapiens	141-146
34029937-15	2021	Our findings suggest that corilagin could be a safe and potential antiviral agent against the COVID-19 acting through the blockade of the fusion of SARS-CoV-2 spike-RBD to hACE2 receptors.	corilagin	26-35	angiotensin converting enzyme 2	Homo sapiens	172-177
34017843-9	2021	The results of the study strongly suggest that increased ACE2 does not increase risk of COVID-19 and that ACEi and ARBs by blocking excessive AT1R-mediated Ang II activation might favor the increase of ACE2-derived Ang 1-7.	arbs	115-119	angiotensin converting enzyme 2	Homo sapiens	202-206
34017843-10	2021	GS/BS patients" increased ACE2 and Ang 1-7 levels and their characteristic chronic metabolic alkalosis suggest a mechanism similar to that of chloroquine/hydroxychloroquine effect on ACE2 glycosylation alteration with resulting SARS-COV-2 binding inhibition and blockage/inhibition of viral entry.	Chloroquine	142-153	angiotensin converting enzyme 2	Homo sapiens	183-187
34017843-10	2021	GS/BS patients" increased ACE2 and Ang 1-7 levels and their characteristic chronic metabolic alkalosis suggest a mechanism similar to that of chloroquine/hydroxychloroquine effect on ACE2 glycosylation alteration with resulting SARS-COV-2 binding inhibition and blockage/inhibition of viral entry.	Hydroxychloroquine	154-172	angiotensin converting enzyme 2	Homo sapiens	183-187
33689451-0	2021	Ribavirin shows antiviral activity against SARS-CoV-2 and downregulates the activity of TMPRSS2 and the expression of ACE2 In Vitro.	Ribavirin	0-9	angiotensin converting enzyme 2	Homo sapiens	118-122
33561649-10	2021	Overall, the study emphasized that curcumin possesses a strong binding ability with host-specific receptors, furin and ACE2.	Curcumin	35-43	angiotensin converting enzyme 2	Homo sapiens	119-123
33556379-4	2021	RA-differentiation induced an upregulation of ace2 and tmprss2 gene expression while inducing downregulation of ctsb and ctsl.	Tretinoin	0-2	angiotensin converting enzyme 2	Homo sapiens	46-50
33539861-1	2021	Membrane-bound angiotensin-converting enzyme 2 (ACE2) is important in regulation of the renin-angiotensin-aldosterone system, but the association of cleaved soluble ACE2 (sACE2) with cardiovascular disease (CVD) is unclear.	Aldosterone	106-117	angiotensin converting enzyme 2	Homo sapiens	15-46
33539861-1	2021	Membrane-bound angiotensin-converting enzyme 2 (ACE2) is important in regulation of the renin-angiotensin-aldosterone system, but the association of cleaved soluble ACE2 (sACE2) with cardiovascular disease (CVD) is unclear.	Aldosterone	106-117	angiotensin converting enzyme 2	Homo sapiens	48-52
33608752-5	2021	In our study, we established an ACE2/CMC bioaffinity chromatography model, and then developed an ACE2/CMC-HPLC-IT-TOF-MS system for the active compounds screening and identification from Ephedra sinica extract.	cmc	102-105	angiotensin converting enzyme 2	Homo sapiens	97-101
33582450-3	2021	Given the requirement of angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 entry into host cells, here we discuss how the downregulation of ACE2 in the COVID-19 patients and virus-induced shift in ACE2 catalytic equilibrium, change the concentrations of substrates such as angiotensin II, apelin-13, dynorphin-13, and products such as angiotensin (1-7), angiotensin (1-9), apelin-12, dynorphin-12 in the human body.	Apelin	302-308	angiotensin converting enzyme 2	Homo sapiens	25-56
33582450-3	2021	Given the requirement of angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 entry into host cells, here we discuss how the downregulation of ACE2 in the COVID-19 patients and virus-induced shift in ACE2 catalytic equilibrium, change the concentrations of substrates such as angiotensin II, apelin-13, dynorphin-13, and products such as angiotensin (1-7), angiotensin (1-9), apelin-12, dynorphin-12 in the human body.	Apelin	302-308	angiotensin converting enzyme 2	Homo sapiens	58-62
33582450-3	2021	Given the requirement of angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 entry into host cells, here we discuss how the downregulation of ACE2 in the COVID-19 patients and virus-induced shift in ACE2 catalytic equilibrium, change the concentrations of substrates such as angiotensin II, apelin-13, dynorphin-13, and products such as angiotensin (1-7), angiotensin (1-9), apelin-12, dynorphin-12 in the human body.	Apelin	302-308	angiotensin converting enzyme 2	Homo sapiens	153-157
33582450-3	2021	Given the requirement of angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 entry into host cells, here we discuss how the downregulation of ACE2 in the COVID-19 patients and virus-induced shift in ACE2 catalytic equilibrium, change the concentrations of substrates such as angiotensin II, apelin-13, dynorphin-13, and products such as angiotensin (1-7), angiotensin (1-9), apelin-12, dynorphin-12 in the human body.	Apelin	302-308	angiotensin converting enzyme 2	Homo sapiens	153-157
33582450-3	2021	Given the requirement of angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 entry into host cells, here we discuss how the downregulation of ACE2 in the COVID-19 patients and virus-induced shift in ACE2 catalytic equilibrium, change the concentrations of substrates such as angiotensin II, apelin-13, dynorphin-13, and products such as angiotensin (1-7), angiotensin (1-9), apelin-12, dynorphin-12 in the human body.	dynorphin-12	397-409	angiotensin converting enzyme 2	Homo sapiens	25-56
33582450-3	2021	Given the requirement of angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 entry into host cells, here we discuss how the downregulation of ACE2 in the COVID-19 patients and virus-induced shift in ACE2 catalytic equilibrium, change the concentrations of substrates such as angiotensin II, apelin-13, dynorphin-13, and products such as angiotensin (1-7), angiotensin (1-9), apelin-12, dynorphin-12 in the human body.	dynorphin-12	397-409	angiotensin converting enzyme 2	Homo sapiens	58-62
33582450-3	2021	Given the requirement of angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 entry into host cells, here we discuss how the downregulation of ACE2 in the COVID-19 patients and virus-induced shift in ACE2 catalytic equilibrium, change the concentrations of substrates such as angiotensin II, apelin-13, dynorphin-13, and products such as angiotensin (1-7), angiotensin (1-9), apelin-12, dynorphin-12 in the human body.	dynorphin-12	397-409	angiotensin converting enzyme 2	Homo sapiens	153-157
33582450-3	2021	Given the requirement of angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 entry into host cells, here we discuss how the downregulation of ACE2 in the COVID-19 patients and virus-induced shift in ACE2 catalytic equilibrium, change the concentrations of substrates such as angiotensin II, apelin-13, dynorphin-13, and products such as angiotensin (1-7), angiotensin (1-9), apelin-12, dynorphin-12 in the human body.	dynorphin-12	397-409	angiotensin converting enzyme 2	Homo sapiens	153-157
33689451-6	2021	The suppressive effect of Ribavirin in ACE2 protein expression was shown to be dependent on cell types.	Ribavirin	26-35	angiotensin converting enzyme 2	Homo sapiens	39-43
33689451-9	2021	As a conclusion, Ribavirin is a potential antiviral drug for the treatment against SARS-CoV-2, and it interferes with the effect of TMPRSS2 and ACE2 expression.	Ribavirin	17-26	angiotensin converting enzyme 2	Homo sapiens	144-148
33786714-7	2021	The primary tumor cells and pituitary cell lines (MMQ, GH3 and AtT-20/D16v-F2) were treated with diminazene aceturate (DIZE), an ACE2 agonist, with various dose regimens.	diminazene aceturate	97-117	angiotensin converting enzyme 2	Homo sapiens	129-133
33731853-2	2021	We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain (RBD) of the viral spike (S) protein and the receptor angiotensin converting enzyme 2 (ACE2).	nabs	30-34	angiotensin converting enzyme 2	Homo sapiens	203-234
33731853-2	2021	We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain (RBD) of the viral spike (S) protein and the receptor angiotensin converting enzyme 2 (ACE2).	nabs	30-34	angiotensin converting enzyme 2	Homo sapiens	236-240
33790994-0	2021	Severe acute respiratory syndrome coronavirus 2 ORF3a induces the expression of ACE2 in oral and pulmonary epithelial cells and the food supplement Vita Deyun  diminishes this effect.	vita deyun	148-158	angiotensin converting enzyme 2	Homo sapiens	80-84
33910120-0	2021	The duplicitous nature of ACE2 in COVID-19 disease EBioMedicine (invited commentary).	ebiomedicine	51-63	angiotensin converting enzyme 2	Homo sapiens	26-30
33631165-5	2021	We found that ACE2 is involved in CC-induced endothelial dysfunction, which inhibits decreases in nitric oxide (NO) level and endothelial nitric oxide synthase (eNOS) activity and increases in inflammatory factors and adhesion molecules.	Nitric Oxide	98-110	angiotensin converting enzyme 2	Homo sapiens	14-18
33790994-4	2021	Therefore, the present study aimed to evaluate the in vitro effects of Vita Deyun on the expression of angiotensin-converting enzyme 2 (ACE2) in diverse cell lines, as well as in the presence or absence of the SARS-CoV-2 open reading frame (ORF)3a protein.	vita deyun	71-81	angiotensin converting enzyme 2	Homo sapiens	103-134
33790994-4	2021	Therefore, the present study aimed to evaluate the in vitro effects of Vita Deyun on the expression of angiotensin-converting enzyme 2 (ACE2) in diverse cell lines, as well as in the presence or absence of the SARS-CoV-2 open reading frame (ORF)3a protein.	vita deyun	71-81	angiotensin converting enzyme 2	Homo sapiens	136-140
33706067-1	2021	While the angiotensin converting enzyme 2 (ACE2) protein is defined as the primary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, the viral serine molecule might be mobilized by the host"s transmembrane protease serine subtype 2 (TMPRSS2) enzyme from the viral spike (S) protein and hijack the host"s N-acetyl-D-galactosamine (GalNAc) metabolism.	Serine	236-242	angiotensin converting enzyme 2	Homo sapiens	10-41
33728680-4	2021	Using all atom molecular dynamics simulations, we demonstrated that Y501 in mutated RBD can be well coordinated by Y41 and K353 in hACE2 through hydrophobic interactions, increasing the overall binding affinity between RBD and hACE2 by about 0.81 kcal/mol.	y501	68-72	angiotensin converting enzyme 2	Homo sapiens	131-136
33728680-4	2021	Using all atom molecular dynamics simulations, we demonstrated that Y501 in mutated RBD can be well coordinated by Y41 and K353 in hACE2 through hydrophobic interactions, increasing the overall binding affinity between RBD and hACE2 by about 0.81 kcal/mol.	y501	68-72	angiotensin converting enzyme 2	Homo sapiens	227-232
33706067-1	2021	While the angiotensin converting enzyme 2 (ACE2) protein is defined as the primary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, the viral serine molecule might be mobilized by the host"s transmembrane protease serine subtype 2 (TMPRSS2) enzyme from the viral spike (S) protein and hijack the host"s N-acetyl-D-galactosamine (GalNAc) metabolism.	Serine	236-242	angiotensin converting enzyme 2	Homo sapiens	43-47
33706067-1	2021	While the angiotensin converting enzyme 2 (ACE2) protein is defined as the primary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, the viral serine molecule might be mobilized by the host"s transmembrane protease serine subtype 2 (TMPRSS2) enzyme from the viral spike (S) protein and hijack the host"s N-acetyl-D-galactosamine (GalNAc) metabolism.	Acetylgalactosamine	325-349	angiotensin converting enzyme 2	Homo sapiens	10-41
33706067-1	2021	While the angiotensin converting enzyme 2 (ACE2) protein is defined as the primary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, the viral serine molecule might be mobilized by the host"s transmembrane protease serine subtype 2 (TMPRSS2) enzyme from the viral spike (S) protein and hijack the host"s N-acetyl-D-galactosamine (GalNAc) metabolism.	Acetylgalactosamine	325-349	angiotensin converting enzyme 2	Homo sapiens	43-47
33706067-1	2021	While the angiotensin converting enzyme 2 (ACE2) protein is defined as the primary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, the viral serine molecule might be mobilized by the host"s transmembrane protease serine subtype 2 (TMPRSS2) enzyme from the viral spike (S) protein and hijack the host"s N-acetyl-D-galactosamine (GalNAc) metabolism.	N-acetylgalactosaminuronic acid	351-357	angiotensin converting enzyme 2	Homo sapiens	10-41
33706067-1	2021	While the angiotensin converting enzyme 2 (ACE2) protein is defined as the primary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, the viral serine molecule might be mobilized by the host"s transmembrane protease serine subtype 2 (TMPRSS2) enzyme from the viral spike (S) protein and hijack the host"s N-acetyl-D-galactosamine (GalNAc) metabolism.	N-acetylgalactosaminuronic acid	351-357	angiotensin converting enzyme 2	Homo sapiens	43-47
33932547-3	2021	In our study, we found that astemizole can antagonize ACE2 and inhibit the entry of SARS-COV-2 spike pseudovirus into ACE2-expressed HEK293T cells (ACE2hi cells).	Astemizole	28-38	angiotensin converting enzyme 2	Homo sapiens	54-58
33580518-0	2021	Three Salvianolic acids inhibit 2019-nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2.	salvianolic acid	6-23	angiotensin converting enzyme 2	Homo sapiens	110-114
33580518-3	2021	In this study, we used Cell Counting Kit-8 staining and flow cytometry to evaluate the toxicity of SAA, SAB, and SAC on ACE2 (angiotensin-converting enzyme 2) high-expressing HEK293T cells (ACE2h cells).	salvianolic acid B	104-107	angiotensin converting enzyme 2	Homo sapiens	120-124
33580518-3	2021	In this study, we used Cell Counting Kit-8 staining and flow cytometry to evaluate the toxicity of SAA, SAB, and SAC on ACE2 (angiotensin-converting enzyme 2) high-expressing HEK293T cells (ACE2h cells).	salvianolic acid B	104-107	angiotensin converting enzyme 2	Homo sapiens	126-157
33580518-3	2021	In this study, we used Cell Counting Kit-8 staining and flow cytometry to evaluate the toxicity of SAA, SAB, and SAC on ACE2 (angiotensin-converting enzyme 2) high-expressing HEK293T cells (ACE2h cells).	salvianolic acid C	113-116	angiotensin converting enzyme 2	Homo sapiens	120-124
33580518-3	2021	In this study, we used Cell Counting Kit-8 staining and flow cytometry to evaluate the toxicity of SAA, SAB, and SAC on ACE2 (angiotensin-converting enzyme 2) high-expressing HEK293T cells (ACE2h cells).	salvianolic acid C	113-116	angiotensin converting enzyme 2	Homo sapiens	126-157
33580518-8	2021	In conclusion, our study revealed that three Salvianolic acids can inhibit the entry of 2019-nCoV spike pseudovirus into ACE2h cells by binding to the RBD of the 2019-nCoV spike protein and ACE2 protein.	salvianolic acid	45-62	angiotensin converting enzyme 2	Homo sapiens	121-125
33881142-8	2021	In culture of pneumocytes, the captopril/candesartan-induced ACE2 up-regulation was associated with inhibition of ADAM17 activity, counterbalancing increased ACE2 expression, which was associated with reduced SARS-CoV-2 spike protein entry.	Captopril	31-40	angiotensin converting enzyme 2	Homo sapiens	61-65
33881142-8	2021	In culture of pneumocytes, the captopril/candesartan-induced ACE2 up-regulation was associated with inhibition of ADAM17 activity, counterbalancing increased ACE2 expression, which was associated with reduced SARS-CoV-2 spike protein entry.	Captopril	31-40	angiotensin converting enzyme 2	Homo sapiens	158-162
33881142-8	2021	In culture of pneumocytes, the captopril/candesartan-induced ACE2 up-regulation was associated with inhibition of ADAM17 activity, counterbalancing increased ACE2 expression, which was associated with reduced SARS-CoV-2 spike protein entry.	candesartan	41-52	angiotensin converting enzyme 2	Homo sapiens	61-65
33881142-8	2021	In culture of pneumocytes, the captopril/candesartan-induced ACE2 up-regulation was associated with inhibition of ADAM17 activity, counterbalancing increased ACE2 expression, which was associated with reduced SARS-CoV-2 spike protein entry.	candesartan	41-52	angiotensin converting enzyme 2	Homo sapiens	158-162
33914735-2	2021	We present a 2.9-A resolution cryo-electron microscopy (cryo-EM) structure of the complex between the ACE2 receptor and N501Y spike protein ectodomains that shows Y501 inserted into a cavity at the binding interface near Y41 of ACE2.	y501	163-167	angiotensin converting enzyme 2	Homo sapiens	102-106
33914735-2	2021	We present a 2.9-A resolution cryo-electron microscopy (cryo-EM) structure of the complex between the ACE2 receptor and N501Y spike protein ectodomains that shows Y501 inserted into a cavity at the binding interface near Y41 of ACE2.	y501	163-167	angiotensin converting enzyme 2	Homo sapiens	228-232
33210357-2	2021	It is theorized that ACE-inhibitors (ACE-Is) or Angiotensin Receptor Blockers (ARBs) may increase vulnerability to SARS-CoV-2 by up-regulating ACE-2 expression, but ACE-I/ARB discontinuation is associated with clinical deterioration.	Iodine	40-43	angiotensin converting enzyme 2	Homo sapiens	143-148
33932547-3	2021	In our study, we found that astemizole can antagonize ACE2 and inhibit the entry of SARS-COV-2 spike pseudovirus into ACE2-expressed HEK293T cells (ACE2hi cells).	Astemizole	28-38	angiotensin converting enzyme 2	Homo sapiens	118-122
33932547-3	2021	In our study, we found that astemizole can antagonize ACE2 and inhibit the entry of SARS-COV-2 spike pseudovirus into ACE2-expressed HEK293T cells (ACE2hi cells).	Astemizole	28-38	angiotensin converting enzyme 2	Homo sapiens	118-122
33932547-4	2021	We analysied the binding character of astemizole to ACE2 by molecular docking and surface plasmon resonance (SPR) assays and molecule docking, SARS-COV-2 spike pseudotype virus was also taken to investigate the suppression viropexis effect of astemizole.	Astemizole	38-48	angiotensin converting enzyme 2	Homo sapiens	52-56
33937889-2	2021	Currently available data point out that ACE2, the receptor of SARS-CoV-2 in host cells, does not predispose the risk or severity of COVID-19, but rather elevated levels of reactive oxygen species (ROS) impose abnormal selection pressure on patients having cardiovascular comorbidities.	Reactive Oxygen Species	197-200	angiotensin converting enzyme 2	Homo sapiens	40-44
33909065-5	2021	In particular, a flat sialic acid-binding domain was proposed at the N-terminal domain (NTD) of the spike protein, which may lead to the initial contact and interaction of the virus on the epithelium followed by higher affinity binding to ACE2 receptor, likely a two-step attachment fashion.	N-Acetylneuraminic Acid	22-33	angiotensin converting enzyme 2	Homo sapiens	239-243
33909065-6	2021	However, recent in vitro and ex vivo studies of sialic acids on ACE2 receptor confirmed an opposite role for SARS-CoV-2 binding.	Sialic Acids	48-60	angiotensin converting enzyme 2	Homo sapiens	64-68
33909065-8	2021	Further, the ACE2 glycosylation mutants indicate that sialic acids on ACE2 receptor prevent ACE2-spike protein interaction.	Sialic Acids	54-66	angiotensin converting enzyme 2	Homo sapiens	13-17
33909065-8	2021	Further, the ACE2 glycosylation mutants indicate that sialic acids on ACE2 receptor prevent ACE2-spike protein interaction.	Sialic Acids	54-66	angiotensin converting enzyme 2	Homo sapiens	70-74
33909065-8	2021	Further, the ACE2 glycosylation mutants indicate that sialic acids on ACE2 receptor prevent ACE2-spike protein interaction.	Sialic Acids	54-66	angiotensin converting enzyme 2	Homo sapiens	70-74
33896392-0	2021	Combined use of the hepatitis C drugs and amentoflavone could interfere with binding of the spike glycoprotein of SARS-CoV-2 to ACE2: the results of a molecular simulation study.	amentoflavone	42-55	angiotensin converting enzyme 2	Homo sapiens	128-132
33981629-0	2021	Fluticasone Propionate Suppresses Poly(I:C)-Induced ACE2 in Primary Human Nasal Epithelial Cells.	Fluticasone	0-22	angiotensin converting enzyme 2	Homo sapiens	52-56
33981629-0	2021	Fluticasone Propionate Suppresses Poly(I:C)-Induced ACE2 in Primary Human Nasal Epithelial Cells.	Poly I-C	34-43	angiotensin converting enzyme 2	Homo sapiens	52-56
33981629-8	2021	Results: Among the TLR agonists, the TLR3 agonist Poly(I:C) significantly increased ACE2 and TMPRSS2 mRNA expression in HNECs (ACE2 36.212+-11.600-fold change, p<0.0001; TMPRSS2 5.598+-2.434-fold change, p=0.031).	Poly I-C	50-59	angiotensin converting enzyme 2	Homo sapiens	84-88
33925881-1	2021	SARS-CoV-2 impairs the renin-angiotensin-aledosterone system via binding ACE2 enzyme.	aledosterone	41-53	angiotensin converting enzyme 2	Homo sapiens	73-77
33981629-8	2021	Results: Among the TLR agonists, the TLR3 agonist Poly(I:C) significantly increased ACE2 and TMPRSS2 mRNA expression in HNECs (ACE2 36.212+-11.600-fold change, p<0.0001; TMPRSS2 5.598+-2.434-fold change, p=0.031).	Poly I-C	50-59	angiotensin converting enzyme 2	Homo sapiens	127-131
33981629-9	2021	The ACE2 protein level was also increased with Poly(I:C) stimulation (2.884+-0.505-fold change, p=0.003).	Poly I-C	47-56	angiotensin converting enzyme 2	Homo sapiens	4-8
33981629-10	2021	The Poly(I:C)-induced ACE2 expression was suppressed by co-incubation with FP (0.405+-0.312-fold change, p=0.044).	Poly I-C	4-13	angiotensin converting enzyme 2	Homo sapiens	22-26
33915212-10	2021	Heparin-binding to the open conformation of spike structurally supports the state and may aid ACE2 binding as reported with cell surface-bound heparan sulfate.	Heparin	0-7	angiotensin converting enzyme 2	Homo sapiens	94-98
33915212-10	2021	Heparin-binding to the open conformation of spike structurally supports the state and may aid ACE2 binding as reported with cell surface-bound heparan sulfate.	Heparitin Sulfate	143-158	angiotensin converting enzyme 2	Homo sapiens	94-98
33915212-13	2021	Studies should be designed to exploit its nanomolar antiviral activity to formulate heparin as topical or inhalation-based formulations, particularly on exposed areas and sites of primary viremia e.g. ACE2 rich epithelia of the eye (conjunctiva/lids), nasal cavity, and mouth.	Heparin	84-91	angiotensin converting enzyme 2	Homo sapiens	201-205
33926110-10	2021	The rollout of COVID-19 vaccines provides opportunities to study the effects of different COVID-19 vaccines on ACE2 in patients on treatment with ACEi/ARB.	acei	146-150	angiotensin converting enzyme 2	Homo sapiens	111-115
33852916-4	2021	We demonstrate that hypoxia and the HIF prolyl hydroxylase inhibitor Roxadustat reduce ACE2 expression and inhibit SARS-CoV-2 entry and replication in lung epithelial cells via an HIF-1alpha-dependent pathway.	roxadustat	69-79	angiotensin converting enzyme 2	Homo sapiens	87-91
33922914-10	2021	Analysis of the RBD-DK07 interaction suggested the formation of hydrogen bonds, electrostatic interactions, and hydrophobic interactions with key residues mediating the ACE2-RBD interaction.	Hydrogen	64-72	angiotensin converting enzyme 2	Homo sapiens	169-173
33895782-0	2021	Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2.	berbamine	0-9	angiotensin converting enzyme 2	Homo sapiens	101-105
33981493-9	2021	MD simulations suggest that cinnamic acid, thymoquinone, and andrographolide (Kalmegh) could efficiently activate the biological pathway without changing the conformation in the binding site of the ACE2 receptor.	cinnamic acid	28-41	angiotensin converting enzyme 2	Homo sapiens	198-202
33981493-9	2021	MD simulations suggest that cinnamic acid, thymoquinone, and andrographolide (Kalmegh) could efficiently activate the biological pathway without changing the conformation in the binding site of the ACE2 receptor.	thymoquinone	43-55	angiotensin converting enzyme 2	Homo sapiens	198-202
33981493-9	2021	MD simulations suggest that cinnamic acid, thymoquinone, and andrographolide (Kalmegh) could efficiently activate the biological pathway without changing the conformation in the binding site of the ACE2 receptor.	andrographolide	61-76	angiotensin converting enzyme 2	Homo sapiens	198-202
33981493-9	2021	MD simulations suggest that cinnamic acid, thymoquinone, and andrographolide (Kalmegh) could efficiently activate the biological pathway without changing the conformation in the binding site of the ACE2 receptor.	kalmegh	78-85	angiotensin converting enzyme 2	Homo sapiens	198-202
33981493-11	2021	Interpretation & Conclusions: The study concludes the high potential of cinnamic acid, thymoquinone, and andrographolide against the SARS-CoV-2 ACE2 receptor protein.	cinnamic acid	72-85	angiotensin converting enzyme 2	Homo sapiens	144-148
33981493-11	2021	Interpretation & Conclusions: The study concludes the high potential of cinnamic acid, thymoquinone, and andrographolide against the SARS-CoV-2 ACE2 receptor protein.	thymoquinone	87-99	angiotensin converting enzyme 2	Homo sapiens	144-148
33981493-11	2021	Interpretation & Conclusions: The study concludes the high potential of cinnamic acid, thymoquinone, and andrographolide against the SARS-CoV-2 ACE2 receptor protein.	andrographolide	105-120	angiotensin converting enzyme 2	Homo sapiens	144-148
33919584-0	2021	Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro.	apabetalone	49-60	angiotensin converting enzyme 2	Homo sapiens	80-84
33963705-5	2021	Flow cytometry was carried out to analyze the effect of Sal-B on the binding of SARS-CoV-2 RBD to hACE2 receptor.	salvianolic acid B	56-61	angiotensin converting enzyme 2	Homo sapiens	98-103
33963705-7	2021	Both Sal-B and ZDDY successfully inhibited the entry of SARS-CoV-2 pseudovirus into the cells that stably expressed human ACE2 (ACE2/293T), with half maximal inhibitory concentrations (IC50) of 1.69 mumol/L and 24.81 mug/mL, respectively.	salvianolic acid B	5-10	angiotensin converting enzyme 2	Homo sapiens	122-126
33963705-7	2021	Both Sal-B and ZDDY successfully inhibited the entry of SARS-CoV-2 pseudovirus into the cells that stably expressed human ACE2 (ACE2/293T), with half maximal inhibitory concentrations (IC50) of 1.69 mumol/L and 24.81 mug/mL, respectively.	salvianolic acid B	5-10	angiotensin converting enzyme 2	Homo sapiens	128-137
33963705-7	2021	Both Sal-B and ZDDY successfully inhibited the entry of SARS-CoV-2 pseudovirus into the cells that stably expressed human ACE2 (ACE2/293T), with half maximal inhibitory concentrations (IC50) of 1.69 mumol/L and 24.81 mug/mL, respectively.	zddy	15-19	angiotensin converting enzyme 2	Homo sapiens	122-126
33963705-7	2021	Both Sal-B and ZDDY successfully inhibited the entry of SARS-CoV-2 pseudovirus into the cells that stably expressed human ACE2 (ACE2/293T), with half maximal inhibitory concentrations (IC50) of 1.69 mumol/L and 24.81 mug/mL, respectively.	zddy	15-19	angiotensin converting enzyme 2	Homo sapiens	128-137
33919584-4	2021	Herein, we demonstrate apabetalone, the most clinical advanced BET inhibitor, downregulates expression of cell surface receptors involved in SARS-CoV-2 entry, including angiotensin-converting enzyme 2 (ACE2) and dipeptidyl-peptidase 4 (DPP4 or CD26) in SARS-CoV-2 permissive cells.	apabetalone	23-34	angiotensin converting enzyme 2	Homo sapiens	169-200
33919584-4	2021	Herein, we demonstrate apabetalone, the most clinical advanced BET inhibitor, downregulates expression of cell surface receptors involved in SARS-CoV-2 entry, including angiotensin-converting enzyme 2 (ACE2) and dipeptidyl-peptidase 4 (DPP4 or CD26) in SARS-CoV-2 permissive cells.	apabetalone	23-34	angiotensin converting enzyme 2	Homo sapiens	202-206
33518803-2	2021	Herein we present the effect of chloroquine (CLQ) on human ACE2 receptor.	Chloroquine	32-43	angiotensin converting enzyme 2	Homo sapiens	59-63
33092925-7	2021	Hydrogen bonds and electrostatic interactions may play vital roles in blocking the receptor ACE2 binding with SARS-CoV-2.	Hydrogen	0-8	angiotensin converting enzyme 2	Homo sapiens	92-96
33518803-2	2021	Herein we present the effect of chloroquine (CLQ) on human ACE2 receptor.	Chloroquine	45-48	angiotensin converting enzyme 2	Homo sapiens	59-63
33518803-4	2021	Furthermore, molecular dynamics (MD) studies with CLQ docked ACE2 results in large fluctuations on RMSD up to 2.3 ns, indicating conformational and rotational changes due to the presence of drug molecule in the ACE2 moiety.	Chloroquine	50-53	angiotensin converting enzyme 2	Homo sapiens	61-65
33518803-4	2021	Furthermore, molecular dynamics (MD) studies with CLQ docked ACE2 results in large fluctuations on RMSD up to 2.3 ns, indicating conformational and rotational changes due to the presence of drug molecule in the ACE2 moiety.	Chloroquine	50-53	angiotensin converting enzyme 2	Homo sapiens	211-215
33518803-6	2021	We believed that this work will help researchers to understand better the effect of CLQ on ACE2.	Chloroquine	84-87	angiotensin converting enzyme 2	Homo sapiens	91-95
33919991-0	2021	L-Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-CoV-2 Infection.	l-carnitine tartrate	0-20	angiotensin converting enzyme 2	Homo sapiens	39-43
33853968-7	2021	By using promoter assays, we show that Zta directly activates methylated ACE2 promoters.	zta	39-42	angiotensin converting enzyme 2	Homo sapiens	73-77
33851732-5	2021	In addition to ACE2, several recent studies have implicated the crucial role cell surface heparan sulfate (HS) as a necessary assisting co-factor for ACE2-mediated SARS-CoV-2 entry.	Heparitin Sulfate	90-105	angiotensin converting enzyme 2	Homo sapiens	150-154
33851732-5	2021	In addition to ACE2, several recent studies have implicated the crucial role cell surface heparan sulfate (HS) as a necessary assisting co-factor for ACE2-mediated SARS-CoV-2 entry.	Heparitin Sulfate	107-109	angiotensin converting enzyme 2	Homo sapiens	150-154
33919991-3	2021	In this study, we show that L-carnitine tartrate supplementation in humans and rodents led to significant decreases of key host dependency factors, notably angiotensin-converting enzyme 2 (ACE2), transmembrane protease serine 2 (TMPRSS2), and Furin, which are responsible for viral attachment, viral spike S-protein cleavage, and priming for viral fusion and entry.	Carnitine	28-39	angiotensin converting enzyme 2	Homo sapiens	189-193
33919991-3	2021	In this study, we show that L-carnitine tartrate supplementation in humans and rodents led to significant decreases of key host dependency factors, notably angiotensin-converting enzyme 2 (ACE2), transmembrane protease serine 2 (TMPRSS2), and Furin, which are responsible for viral attachment, viral spike S-protein cleavage, and priming for viral fusion and entry.	Carnitine	28-39	angiotensin converting enzyme 2	Homo sapiens	156-187
33847382-4	2021	In this study, we observed that seabuckthorn and its flavonoid compounds quercetin and isorhamnetin were shown strong retention to ACE2 overexpression HEK293 (ACE2h ) cells by CMC analysis.	Flavonoids	53-62	angiotensin converting enzyme 2	Homo sapiens	131-135
33855640-8	2021	After tamoxifen administration, the copy number of the STOP cassette was decreased, and the offspring expressed hACE2 and GFP, confirming the efficiency of our system.	Tamoxifen	6-15	angiotensin converting enzyme 2	Homo sapiens	112-117
33847382-4	2021	In this study, we observed that seabuckthorn and its flavonoid compounds quercetin and isorhamnetin were shown strong retention to ACE2 overexpression HEK293 (ACE2h ) cells by CMC analysis.	Quercetin	73-82	angiotensin converting enzyme 2	Homo sapiens	131-135
33847382-4	2021	In this study, we observed that seabuckthorn and its flavonoid compounds quercetin and isorhamnetin were shown strong retention to ACE2 overexpression HEK293 (ACE2h ) cells by CMC analysis.	3-methylquercetin	87-99	angiotensin converting enzyme 2	Homo sapiens	131-135
33847382-4	2021	In this study, we observed that seabuckthorn and its flavonoid compounds quercetin and isorhamnetin were shown strong retention to ACE2 overexpression HEK293 (ACE2h ) cells by CMC analysis.	cmc	176-179	angiotensin converting enzyme 2	Homo sapiens	131-135
33847382-6	2021	Surface plasmon resonance assay proved the effect that isorhamnetin bound to the ACE2, and its affinity (KD value) was at the micromolar level, that was, 2.51 +- 0.68 muM.	3-methylquercetin	55-67	angiotensin converting enzyme 2	Homo sapiens	81-85
33847382-7	2021	Viral entry studies in vitro indicated that isorhamnetin inhibited SARS-CoV-2 spike pseudotyped virus entering ACE2h cells.	3-methylquercetin	44-56	angiotensin converting enzyme 2	Homo sapiens	111-115
33921378-1	2021	To determine whether quaternary ammonium (k21) binds to Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) spike protein via computational molecular docking simulations, the crystal structure of the SARS-CoV-2 spike receptor-binding domain complexed with ACE-2 (PDB ID: 6LZG) was downloaded from RCSB PD and prepared using Schrodinger 2019-4.	k21	42-45	angiotensin converting enzyme 2	Homo sapiens	265-270
33868761-0	2021	Human ACE2-Functionalized Gold "Virus-Trap" Nanostructures for Accurate Capture of SARS-CoV-2 and Single-Virus SERS Detection.	Serine	111-115	angiotensin converting enzyme 2	Homo sapiens	6-10
33868761-2	2021	Here, we present a Human Angiotensin-converting-enzyme 2 (ACE2)-functionalized gold "virus traps" nanostructure as an extremely sensitive SERS biosensor, to selectively capture and rapidly detect S-protein expressed coronavirus, such as the current SARS-CoV-2 in the contaminated water, down to the single-virus level.	Serine	138-142	angiotensin converting enzyme 2	Homo sapiens	25-56
33868761-2	2021	Here, we present a Human Angiotensin-converting-enzyme 2 (ACE2)-functionalized gold "virus traps" nanostructure as an extremely sensitive SERS biosensor, to selectively capture and rapidly detect S-protein expressed coronavirus, such as the current SARS-CoV-2 in the contaminated water, down to the single-virus level.	Serine	138-142	angiotensin converting enzyme 2	Homo sapiens	58-62
33868761-2	2021	Here, we present a Human Angiotensin-converting-enzyme 2 (ACE2)-functionalized gold "virus traps" nanostructure as an extremely sensitive SERS biosensor, to selectively capture and rapidly detect S-protein expressed coronavirus, such as the current SARS-CoV-2 in the contaminated water, down to the single-virus level.	Water	280-285	angiotensin converting enzyme 2	Homo sapiens	25-56
33868761-2	2021	Here, we present a Human Angiotensin-converting-enzyme 2 (ACE2)-functionalized gold "virus traps" nanostructure as an extremely sensitive SERS biosensor, to selectively capture and rapidly detect S-protein expressed coronavirus, such as the current SARS-CoV-2 in the contaminated water, down to the single-virus level.	Water	280-285	angiotensin converting enzyme 2	Homo sapiens	58-62
33868761-3	2021	Such a SERS sensor features extraordinary 106-fold virus enrichment originating from high-affinity of ACE2 with S protein as well as "virus-traps" composed of oblique gold nanoneedles, and 109-fold enhancement of Raman signals originating from multi-component SERS effects.	Serine	7-11	angiotensin converting enzyme 2	Homo sapiens	102-106
33850935-0	2021	Nicotine upregulates ACE2 expression and increases competence for SARS-CoV-2 in human pneumocytes.	Nicotine	0-8	angiotensin converting enzyme 2	Homo sapiens	21-25
33850935-4	2021	We exposed low angiotensin-converting enzyme 2 (ACE2)-expressing human pulmonary adenocarcinoma A549 epithelial cells to nicotine and assessed ACE2 expression at different times.	Nicotine	121-129	angiotensin converting enzyme 2	Homo sapiens	15-46
33850935-4	2021	We exposed low angiotensin-converting enzyme 2 (ACE2)-expressing human pulmonary adenocarcinoma A549 epithelial cells to nicotine and assessed ACE2 expression at different times.	Nicotine	121-129	angiotensin converting enzyme 2	Homo sapiens	48-52
33850935-6	2021	Nicotine exposure induces rapid and long-lasting increases in gene and protein expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor ACE2, which in turn translates into increased competence for SARS-CoV-2 replication and cytopathic effect.	Nicotine	0-8	angiotensin converting enzyme 2	Homo sapiens	167-171
33921378-1	2021	To determine whether quaternary ammonium (k21) binds to Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) spike protein via computational molecular docking simulations, the crystal structure of the SARS-CoV-2 spike receptor-binding domain complexed with ACE-2 (PDB ID: 6LZG) was downloaded from RCSB PD and prepared using Schrodinger 2019-4.	quaternary ammonium	21-40	angiotensin converting enzyme 2	Homo sapiens	265-270
33850236-0	2021	Author Correction: Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies.	Catechin	19-27	angiotensin converting enzyme 2	Homo sapiens	82-86
33850236-0	2021	Author Correction: Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies.	Curcumin	32-40	angiotensin converting enzyme 2	Homo sapiens	82-86
33867777-7	2021	Three different computer modeling techniques reveal that ivermectin is more stable than levosalbutamol in the active site of spike protein where hACE2 binds.	Levalbuterol	88-102	angiotensin converting enzyme 2	Homo sapiens	145-150
33888980-7	2021	The results of molecular docking revealed that Taxol, Rutin, Genkwanine, and Luteolin-glucoside have a high affinity with ACE2 and 3CLpro.	Paclitaxel	47-52	angiotensin converting enzyme 2	Homo sapiens	122-126
33918670-6	2021	In human Caco-2 colon epithelial cells as well as the lung cell line A549 stably expressing ACE2 and TMPRSS2, quinine also showed antiviral activity.	Quinine	110-117	angiotensin converting enzyme 2	Homo sapiens	92-96
33888980-7	2021	The results of molecular docking revealed that Taxol, Rutin, Genkwanine, and Luteolin-glucoside have a high affinity with ACE2 and 3CLpro.	Rutin	54-59	angiotensin converting enzyme 2	Homo sapiens	122-126
33888980-7	2021	The results of molecular docking revealed that Taxol, Rutin, Genkwanine, and Luteolin-glucoside have a high affinity with ACE2 and 3CLpro.	genkwanine	61-71	angiotensin converting enzyme 2	Homo sapiens	122-126
33888980-7	2021	The results of molecular docking revealed that Taxol, Rutin, Genkwanine, and Luteolin-glucoside have a high affinity with ACE2 and 3CLpro.	luteolin-glucoside	77-95	angiotensin converting enzyme 2	Homo sapiens	122-126
33174669-3	2021	Inhibition of the SARS CoV-2 RBD / ACE2 PPI is currently being evaluated asa target for therapeutic and/or prophylactic intervention.	Aspirin	73-76	angiotensin converting enzyme 2	Homo sapiens	35-39
33174669-6	2021	Computational alanine scanning mutagenesis wasperformed to predict changes in Gibbs" free energy that are associated with mutatingresidues at the positive control (PMI/MDM2) or SARS RBD/ACE2 binding interface toalanine.	Alanine	14-21	angiotensin converting enzyme 2	Homo sapiens	186-190
33174669-6	2021	Computational alanine scanning mutagenesis wasperformed to predict changes in Gibbs" free energy that are associated with mutatingresidues at the positive control (PMI/MDM2) or SARS RBD/ACE2 binding interface toalanine.	toalanine	209-218	angiotensin converting enzyme 2	Homo sapiens	186-190
33174669-9	2021	Collectively, this studyilluminates predicted hot-spot residues, and clusters, at the SARS CoV-2 RBD / ACE2binding interface, potentially guiding the development of reagents capable of disruptingthis complex and halting COVID-19.	studyilluminates	19-35	angiotensin converting enzyme 2	Homo sapiens	103-107
33797339-0	2021	COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays.	Withanolides	31-43	angiotensin converting enzyme 2	Homo sapiens	97-101
33497607-0	2021	Repositioning of histamine H1 receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2.	Doxepin	51-58	angiotensin converting enzyme 2	Homo sapiens	122-126
33497607-8	2021	Through the pseudovirus assay, we finally identified that doxepin could inhibit SARS-CoV-2 spike pseudovirus from entering the ACE2-expressing cell, reducing the infection rate to 25.82%.	Doxepin	58-65	angiotensin converting enzyme 2	Homo sapiens	127-131
33842675-6	2021	All the phytochemicals follow Lipinski"s rule of five and molecular docking result shows best binding affinity of Podofilox - 7.54 kcal/mol with ACE2, Psoralidin - 8.04 kcal/mol with Furin, Ursolic acid - 8.88 kcal/mol with 3CLpro and Epiafzelechin - 8.26 kcal/mol with RdRp.	Podophyllotoxin	114-123	angiotensin converting enzyme 2	Homo sapiens	145-149
33842675-7	2021	Thus, blocking two human receptors ACE2 and Furin with Podofilox and Psoralidin respectively may prevent the viral entry into the cells.	Podophyllotoxin	55-64	angiotensin converting enzyme 2	Homo sapiens	35-39
33842675-7	2021	Thus, blocking two human receptors ACE2 and Furin with Podofilox and Psoralidin respectively may prevent the viral entry into the cells.	psoralidin	69-79	angiotensin converting enzyme 2	Homo sapiens	35-39
33651072-2	2021	We set out to develop lactam-based i,i + 4 stapled hACE2 peptides targeting SARS-CoV-2.	Lactams	22-28	angiotensin converting enzyme 2	Homo sapiens	51-56
33797339-4	2021	We investigated therapeutic efficacy of eight withanolides (derived from Ashwagandha) against the angiotensin-converting enzyme 2 (ACE2) proteins, a target cell surface receptor for SARS-CoV-2 and report results on the (i) computational analyses including binding affinity and stable interactions with ACE2, occupancy of ACE2 residues in making polar and nonpolar interactions with different withanolides/ligands and (2) in vitro mRNA and protein analyses using human cancer (A549, MCF7 and HSC3) cells.	Withanolides	46-58	angiotensin converting enzyme 2	Homo sapiens	131-135
33797339-4	2021	We investigated therapeutic efficacy of eight withanolides (derived from Ashwagandha) against the angiotensin-converting enzyme 2 (ACE2) proteins, a target cell surface receptor for SARS-CoV-2 and report results on the (i) computational analyses including binding affinity and stable interactions with ACE2, occupancy of ACE2 residues in making polar and nonpolar interactions with different withanolides/ligands and (2) in vitro mRNA and protein analyses using human cancer (A549, MCF7 and HSC3) cells.	Withanolides	46-58	angiotensin converting enzyme 2	Homo sapiens	302-306
33797339-4	2021	We investigated therapeutic efficacy of eight withanolides (derived from Ashwagandha) against the angiotensin-converting enzyme 2 (ACE2) proteins, a target cell surface receptor for SARS-CoV-2 and report results on the (i) computational analyses including binding affinity and stable interactions with ACE2, occupancy of ACE2 residues in making polar and nonpolar interactions with different withanolides/ligands and (2) in vitro mRNA and protein analyses using human cancer (A549, MCF7 and HSC3) cells.	Withanolides	46-58	angiotensin converting enzyme 2	Homo sapiens	302-306
33797339-4	2021	We investigated therapeutic efficacy of eight withanolides (derived from Ashwagandha) against the angiotensin-converting enzyme 2 (ACE2) proteins, a target cell surface receptor for SARS-CoV-2 and report results on the (i) computational analyses including binding affinity and stable interactions with ACE2, occupancy of ACE2 residues in making polar and nonpolar interactions with different withanolides/ligands and (2) in vitro mRNA and protein analyses using human cancer (A549, MCF7 and HSC3) cells.	Withanolides	392-404	angiotensin converting enzyme 2	Homo sapiens	131-135
33797339-5	2021	We found that among all withanolides, Withaferin-A, Withanone, Withanoside-IV and Withanoside-V significantly inhibited the ACE2 expression.	Withanolides	24-36	angiotensin converting enzyme 2	Homo sapiens	124-128
33797339-5	2021	We found that among all withanolides, Withaferin-A, Withanone, Withanoside-IV and Withanoside-V significantly inhibited the ACE2 expression.	withaferin A	38-50	angiotensin converting enzyme 2	Homo sapiens	124-128
33797339-5	2021	We found that among all withanolides, Withaferin-A, Withanone, Withanoside-IV and Withanoside-V significantly inhibited the ACE2 expression.	withanone	52-61	angiotensin converting enzyme 2	Homo sapiens	124-128
33797339-5	2021	We found that among all withanolides, Withaferin-A, Withanone, Withanoside-IV and Withanoside-V significantly inhibited the ACE2 expression.	withanoside	63-74	angiotensin converting enzyme 2	Homo sapiens	124-128
33797339-5	2021	We found that among all withanolides, Withaferin-A, Withanone, Withanoside-IV and Withanoside-V significantly inhibited the ACE2 expression.	withanoside	82-93	angiotensin converting enzyme 2	Homo sapiens	124-128
33797339-6	2021	Analysis of withanolides-rich aqueous extracts derived from Ashwagandha leaves and stem showed a higher ACE2 inhibitory potency of stem-derived extracts.	Withanolides	12-24	angiotensin converting enzyme 2	Homo sapiens	104-108
33606395-5	2021	We also found ACE2 mRNA in atrial appendage tissue from cardiac surgical patients to be positively associated with age, elevated by certain comorbid conditions (e.g. COPD and previous stroke) and increased in conjunction with patients" chronic use of antithrombotic agents and thiazide diuretics but not drugs that block the renin--angiotensin system.	Thiazides	277-285	angiotensin converting enzyme 2	Homo sapiens	14-18
33821267-4	2021	The crystal structure of the most potent antibody, CV503, revealed that it binds to the ridge region of SARS-CoV-2 RBD, competes with the ACE2 receptor, and has limited contact with key variant residues K417, E484 and N501.	cv503	51-56	angiotensin converting enzyme 2	Homo sapiens	138-142
33609497-4	2021	In this study, in vitro severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike pseudotyped viral infection experiments indicated that histamine H1 antagonists loratadine (LOR) and desloratadine (DES) could prevent entry of the pseudotyped virus into ACE2-overexpressing HEK293T cells and showed that DES was more effective.	Histamine	146-155	angiotensin converting enzyme 2	Homo sapiens	262-266
33609497-4	2021	In this study, in vitro severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike pseudotyped viral infection experiments indicated that histamine H1 antagonists loratadine (LOR) and desloratadine (DES) could prevent entry of the pseudotyped virus into ACE2-overexpressing HEK293T cells and showed that DES was more effective.	Loratadine	171-181	angiotensin converting enzyme 2	Homo sapiens	262-266
33609497-4	2021	In this study, in vitro severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike pseudotyped viral infection experiments indicated that histamine H1 antagonists loratadine (LOR) and desloratadine (DES) could prevent entry of the pseudotyped virus into ACE2-overexpressing HEK293T cells and showed that DES was more effective.	desloratadine	192-205	angiotensin converting enzyme 2	Homo sapiens	262-266
33609497-4	2021	In this study, in vitro severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike pseudotyped viral infection experiments indicated that histamine H1 antagonists loratadine (LOR) and desloratadine (DES) could prevent entry of the pseudotyped virus into ACE2-overexpressing HEK293T cells and showed that DES was more effective.	desloratadine	207-210	angiotensin converting enzyme 2	Homo sapiens	262-266
33609497-5	2021	Further binding experiments using cell membrane chromatography and surface plasmon resonance demonstrated that both antagonists could bind to ACE2 and that the binding affinity of DES was much stronger than that of LOR.	desloratadine	180-183	angiotensin converting enzyme 2	Homo sapiens	142-146
33609497-6	2021	Molecular docking results elucidated that LOR and DES could bind to ACE2 on the interface of the SARS-CoV-2-binding area.	Loratadine	42-45	angiotensin converting enzyme 2	Homo sapiens	68-72
33609497-6	2021	Molecular docking results elucidated that LOR and DES could bind to ACE2 on the interface of the SARS-CoV-2-binding area.	desloratadine	50-53	angiotensin converting enzyme 2	Homo sapiens	68-72
32913304-7	2021	Furthermore, treatment with vitamin C blocked IL7-induced ACE2 expression.	Ascorbic Acid	28-37	angiotensin converting enzyme 2	Homo sapiens	58-62
33571798-1	2021	Molecular docking studies were done to show the inhibitory effect of two naturally occurring biflavone based anti-HIV agents, hinokiflavone and robustaflavone against the SARS-CoV-2 spike (S) protein mediated attack on the human ACE2 receptors via membrane fusion mechanism.	biflavone	93-102	angiotensin converting enzyme 2	Homo sapiens	229-233
33184809-9	2021	Both the molecules curcumin and catechin get bound directly to receptors binding domain of S-protein and ACE-2 receptors of host cell, due to which these molecules inhibit the entry of virus in host cell i. e. animal survives from being infected.	Curcumin	19-27	angiotensin converting enzyme 2	Homo sapiens	105-110
33184809-9	2021	Both the molecules curcumin and catechin get bound directly to receptors binding domain of S-protein and ACE-2 receptors of host cell, due to which these molecules inhibit the entry of virus in host cell i. e. animal survives from being infected.	Catechin	32-40	angiotensin converting enzyme 2	Homo sapiens	105-110
33511555-2	2021	Here, we show that cigarette smoke extract (CSE) and carcinogen benzo(a)pyrene (BaP) increase ACE2 mRNA but trigger ACE2 protein catabolism.	Benzo(a)pyrene	64-78	angiotensin converting enzyme 2	Homo sapiens	94-98
33511555-2	2021	Here, we show that cigarette smoke extract (CSE) and carcinogen benzo(a)pyrene (BaP) increase ACE2 mRNA but trigger ACE2 protein catabolism.	Benzo(a)pyrene	64-78	angiotensin converting enzyme 2	Homo sapiens	116-120
33511555-2	2021	Here, we show that cigarette smoke extract (CSE) and carcinogen benzo(a)pyrene (BaP) increase ACE2 mRNA but trigger ACE2 protein catabolism.	Benzo(a)pyrene	80-83	angiotensin converting enzyme 2	Homo sapiens	94-98
33511555-2	2021	Here, we show that cigarette smoke extract (CSE) and carcinogen benzo(a)pyrene (BaP) increase ACE2 mRNA but trigger ACE2 protein catabolism.	Benzo(a)pyrene	80-83	angiotensin converting enzyme 2	Homo sapiens	116-120
33511555-3	2021	BaP induces an aryl hydrocarbon receptor (AhR)-dependent upregulation of the ubiquitin E3 ligase Skp2 for ACE2 ubiquitination.	Benzo(a)pyrene	0-3	angiotensin converting enzyme 2	Homo sapiens	106-110
33422689-1	2021	Angiotensin-converting enzyme 2 (ACE2) is an important player of the renin-angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II into angiotensin (1-7).	Aldosterone	87-98	angiotensin converting enzyme 2	Homo sapiens	0-31
33422689-1	2021	Angiotensin-converting enzyme 2 (ACE2) is an important player of the renin-angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II into angiotensin (1-7).	Aldosterone	87-98	angiotensin converting enzyme 2	Homo sapiens	33-37
33609497-8	2021	To our knowledge, this study is the first to demonstrate the inhibitory effect of LOR and DES on SARS-CoV-2 spike pseudotyped virus viropexis by blocking spike protein-ACE2 interaction.	Loratadine	82-85	angiotensin converting enzyme 2	Homo sapiens	168-172
33609497-8	2021	To our knowledge, this study is the first to demonstrate the inhibitory effect of LOR and DES on SARS-CoV-2 spike pseudotyped virus viropexis by blocking spike protein-ACE2 interaction.	desloratadine	90-93	angiotensin converting enzyme 2	Homo sapiens	168-172
33714595-7	2021	On the basis of our review of the published literature, we speculate that several unifying cutaneous and systemic mechanisms may explain COVID-19-associated pernio: (1) SARS-CoV-2 cell infection occurs through the cellular receptor angiotensin-converting enzyme 2 mediated by transmembrane protease serine 2, subsequently affecting the renin-angiotensin-aldosterone system with an increase in the vasoconstricting, pro-inflammatory, and prothrombotic angiotensin II pathway.	Aldosterone	354-365	angiotensin converting enzyme 2	Homo sapiens	232-263
33571798-1	2021	Molecular docking studies were done to show the inhibitory effect of two naturally occurring biflavone based anti-HIV agents, hinokiflavone and robustaflavone against the SARS-CoV-2 spike (S) protein mediated attack on the human ACE2 receptors via membrane fusion mechanism.	hinokiflavone	126-139	angiotensin converting enzyme 2	Homo sapiens	229-233
33571798-1	2021	Molecular docking studies were done to show the inhibitory effect of two naturally occurring biflavone based anti-HIV agents, hinokiflavone and robustaflavone against the SARS-CoV-2 spike (S) protein mediated attack on the human ACE2 receptors via membrane fusion mechanism.	robustaflavone	144-158	angiotensin converting enzyme 2	Homo sapiens	229-233
33790352-2	2021	Keeping this hypothesis intact, the present study describes for the first-time, Grazoprevir, an FDA approved anti-viral drug primarily approved for Hepatitis C Virus (HCV), mediated multiple pathway control via synergistic inhibition of viral entry targeting host cell Angiotensin-Converting Enzyme 2 (ACE-2)/transmembrane serine protease 2 (TMPRSS2) and viral replication targeting RNA-dependent RNA polymerase (RdRP).	grazoprevir	80-91	angiotensin converting enzyme 2	Homo sapiens	269-300
33790352-2	2021	Keeping this hypothesis intact, the present study describes for the first-time, Grazoprevir, an FDA approved anti-viral drug primarily approved for Hepatitis C Virus (HCV), mediated multiple pathway control via synergistic inhibition of viral entry targeting host cell Angiotensin-Converting Enzyme 2 (ACE-2)/transmembrane serine protease 2 (TMPRSS2) and viral replication targeting RNA-dependent RNA polymerase (RdRP).	grazoprevir	80-91	angiotensin converting enzyme 2	Homo sapiens	302-307
33859566-5	2021	Interestingly, we observed a positive direct correlation between ACE-2 reduction and nicotine delivery.	Nicotine	85-93	angiotensin converting enzyme 2	Homo sapiens	65-70
33784482-10	2021	These results conclusively demonstrate that the calcium independent rfhSP-D mediated inhibition of binding between the receptor binding domain of the S1 subunit of the SARS-CoV-2 spike protein and human ACE-2, its host cell receptor, and a significant reduction in SARS-CoV-2 infection and replication in-vitro.	Calcium	48-55	angiotensin converting enzyme 2	Homo sapiens	203-208
33458761-5	2021	ACE2 usually converts Angiotensin I in the renin-angiotensin-aldosterone system to Angiotensin II, which affects blood pressure levels.	Aldosterone	61-72	angiotensin converting enzyme 2	Homo sapiens	0-4
33683322-8	2021	RB150/firibastat treatment constitutes an interesting therapeutic approach to improve BP control in hypertensive patients by inducing in the brain renin-angiotensin system, hyperactivity of the beneficial ACE2/Ang 1-7/MasR axis while decreasing that of the deleterious APA/Ang II/Ang III/ATI receptor axis.	firibastat	6-16	angiotensin converting enzyme 2	Homo sapiens	205-209
33469977-2	2021	Simulations suggest that linoleate and dexamethasone stabilize the locked spike conformation, thus reducing the opportunity for ACE2 interaction.	Linoleic Acid	25-34	angiotensin converting enzyme 2	Homo sapiens	128-132
33469977-2	2021	Simulations suggest that linoleate and dexamethasone stabilize the locked spike conformation, thus reducing the opportunity for ACE2 interaction.	Dexamethasone	39-52	angiotensin converting enzyme 2	Homo sapiens	128-132
33791699-2	2021	Here, we applied live bioluminescence imaging (BLI) to monitor the real-time effects of NAb treatment in prophylaxis and therapy of K18-hACE2 mice intranasally infected with SARS-CoV-2-nanoluciferase.	nab	88-91	angiotensin converting enzyme 2	Homo sapiens	136-141
33607086-8	2021	SMD results indicate that CoV-2 RBD interacts with the N-linked glycan on Asn90 of ACE2.	n-linked glycan	55-70	angiotensin converting enzyme 2	Homo sapiens	83-87
33657325-7	2021	This weakening of binding strength was observed to be due to the destabilization of the interactions between ACE2 residues Glu-35, Glu-37, Tyr-83, Lys-353, and Arg-393 and the SARS-CoV-2 s-protein receptor binding domain (RBD).	Glutamic Acid	123-126	angiotensin converting enzyme 2	Homo sapiens	109-113
33657325-7	2021	This weakening of binding strength was observed to be due to the destabilization of the interactions between ACE2 residues Glu-35, Glu-37, Tyr-83, Lys-353, and Arg-393 and the SARS-CoV-2 s-protein receptor binding domain (RBD).	Glutamic Acid	131-134	angiotensin converting enzyme 2	Homo sapiens	109-113
33657325-7	2021	This weakening of binding strength was observed to be due to the destabilization of the interactions between ACE2 residues Glu-35, Glu-37, Tyr-83, Lys-353, and Arg-393 and the SARS-CoV-2 s-protein receptor binding domain (RBD).	Tyrosine	139-142	angiotensin converting enzyme 2	Homo sapiens	109-113
33657325-7	2021	This weakening of binding strength was observed to be due to the destabilization of the interactions between ACE2 residues Glu-35, Glu-37, Tyr-83, Lys-353, and Arg-393 and the SARS-CoV-2 s-protein receptor binding domain (RBD).	Lysine	147-150	angiotensin converting enzyme 2	Homo sapiens	109-113
33657325-7	2021	This weakening of binding strength was observed to be due to the destabilization of the interactions between ACE2 residues Glu-35, Glu-37, Tyr-83, Lys-353, and Arg-393 and the SARS-CoV-2 s-protein receptor binding domain (RBD).	Arginine	160-163	angiotensin converting enzyme 2	Homo sapiens	109-113
33758862-5	2021	We demonstrate circadian regulation of ACE2 in lung epithelial cells and show that silencing BMAL1 or treatment with the synthetic REV-ERB agonist SR9009 reduces ACE2 expression and inhibits SARS-CoV-2 entry and RNA replication.	SR9009	147-153	angiotensin converting enzyme 2	Homo sapiens	39-43
33758862-5	2021	We demonstrate circadian regulation of ACE2 in lung epithelial cells and show that silencing BMAL1 or treatment with the synthetic REV-ERB agonist SR9009 reduces ACE2 expression and inhibits SARS-CoV-2 entry and RNA replication.	SR9009	147-153	angiotensin converting enzyme 2	Homo sapiens	162-166
33607086-12	2021	After removing N-linked glycans on ACE2, its mechanical binding strength with CoV-2 RBD decreases to a similar level of the CoV-1 RBD-ACE2 interaction.	n-linked glycans	15-31	angiotensin converting enzyme 2	Homo sapiens	35-39
33758841-2	2021	Here we report a human soluble ACE2 variant fused with a 5kD albumin binding domain (ABD) and bridged via a dimerization motif hinge-like 4-cysteine dodecapeptide, which we term ACE2 1-618-DDC-ABD.	4-cysteine dodecapeptide	138-162	angiotensin converting enzyme 2	Homo sapiens	31-35
33758527-10	2021	Conclusion: Coronil prevented SARS-CoV-2 S-protein mediated viral entry into A549 cells by inhibiting spike protein-ACE-2 interactions.	coronil	12-19	angiotensin converting enzyme 2	Homo sapiens	116-121
33758527-0	2021	Coronil, a Tri-Herbal Formulation, Attenuates Spike-Protein-Mediated SARS-CoV-2 Viral Entry into Human Alveolar Epithelial Cells and Pro-Inflammatory Cytokines Production by Inhibiting Spike Protein-ACE-2 Interaction.	coronil	0-7	angiotensin converting enzyme 2	Homo sapiens	199-204
33758527-4	2021	Methods: Through an ELISA-based biochemical assay, effects of Coronil on interaction between ACE-2 and different mutants of viral spike (S) protein, crucial for viral invasion of host cell, were evaluated.	coronil	62-69	angiotensin converting enzyme 2	Homo sapiens	93-98
33758527-7	2021	Results: Coronil effectively inhibited the interaction of ACE-2 not only with the wild-type S protein (SWT) but also with its currently prevalent and more infectious variant (SD614G) and another mutant (SW436R) with significantly higher affinity toward ACE-2.	coronil	9-16	angiotensin converting enzyme 2	Homo sapiens	58-63
33758527-7	2021	Results: Coronil effectively inhibited the interaction of ACE-2 not only with the wild-type S protein (SWT) but also with its currently prevalent and more infectious variant (SD614G) and another mutant (SW436R) with significantly higher affinity toward ACE-2.	coronil	9-16	angiotensin converting enzyme 2	Homo sapiens	253-258
33758841-2	2021	Here we report a human soluble ACE2 variant fused with a 5kD albumin binding domain (ABD) and bridged via a dimerization motif hinge-like 4-cysteine dodecapeptide, which we term ACE2 1-618-DDC-ABD.	4-cysteine dodecapeptide	138-162	angiotensin converting enzyme 2	Homo sapiens	178-182
33082599-6	2021	One of the possible inhibition pathways is the competitive binding with the angiotension-converting enzyme-2 (ACE-2), in particular with the cellular Sialic acid (Neu5Ac).	angiotension	76-88	angiotensin converting enzyme 2	Homo sapiens	110-115
33082599-6	2021	One of the possible inhibition pathways is the competitive binding with the angiotension-converting enzyme-2 (ACE-2), in particular with the cellular Sialic acid (Neu5Ac).	N-Acetylneuraminic Acid	150-161	angiotensin converting enzyme 2	Homo sapiens	110-115
33082599-6	2021	One of the possible inhibition pathways is the competitive binding with the angiotension-converting enzyme-2 (ACE-2), in particular with the cellular Sialic acid (Neu5Ac).	N-Acetylneuraminic Acid	163-169	angiotensin converting enzyme 2	Homo sapiens	110-115
33706759-8	2021	ACE2 and TMPRSS2 were also expressed in FSP-1+ lung fibroblasts in bleomycin-induced pulmonary fibrosis, and when combined with PM exposure, they were further upregulated.	Bleomycin	67-76	angiotensin converting enzyme 2	Homo sapiens	0-4
33737804-0	2021	Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model.	withanone	0-9	angiotensin converting enzyme 2	Homo sapiens	69-73
33737804-5	2021	Methods: Through molecular docking, molecular dynamic (MD) simulation and electrostatic energy calculation the plausible biochemical interactions between withanone and the ACE2-RBD complex were investigated.	withanone	154-163	angiotensin converting enzyme 2	Homo sapiens	172-176
33737804-8	2021	Results: Withanone bound efficiently at the interacting interface of the ACE2-RBD complex and destabilized it energetically.	withanone	9-18	angiotensin converting enzyme 2	Homo sapiens	73-77
33737804-10	2021	The two intrachain salt bridge interactions (K31-E35) and the interchain long-range ion-pair (K31-E484), at the ACE2-RBD interface were completely abolished by withanone, in the 50 ns simulation.	withanone	160-169	angiotensin converting enzyme 2	Homo sapiens	112-116
33737804-11	2021	In vitro binding assay experimentally validated that withanone efficiently inhibited (IC50=0.33 ng/mL) the interaction between ACE2 and RBD, in a dose-dependent manner.	withanone	53-62	angiotensin converting enzyme 2	Homo sapiens	127-131
33758861-12	2021	While the functional impact of L452R has not yet been extensively evaluated, leucine-452 is positioned in the receptor-binding motif of RBD, in the interface of direct contact with the ACE2 receptor.	Leucine	77-84	angiotensin converting enzyme 2	Homo sapiens	185-189
33706683-3	2021	The results of the docking simulation revealed that methyl-1,4,5-tri-O-cafeoyl quinate has a stronger bond, high affinity and gives the best docking scores compared to, the co-crystallized inhibitor (PRD_002214) of the enzyme ACE2, chloroquine, hydroxychloroquine, captopril and simerprevir antiviral drugs.	methyl-1,4,5-tri-o-cafeoyl quinate	52-86	angiotensin converting enzyme 2	Homo sapiens	226-230
33706683-3	2021	The results of the docking simulation revealed that methyl-1,4,5-tri-O-cafeoyl quinate has a stronger bond, high affinity and gives the best docking scores compared to, the co-crystallized inhibitor (PRD_002214) of the enzyme ACE2, chloroquine, hydroxychloroquine, captopril and simerprevir antiviral drugs.	Chloroquine	232-243	angiotensin converting enzyme 2	Homo sapiens	226-230
33706683-3	2021	The results of the docking simulation revealed that methyl-1,4,5-tri-O-cafeoyl quinate has a stronger bond, high affinity and gives the best docking scores compared to, the co-crystallized inhibitor (PRD_002214) of the enzyme ACE2, chloroquine, hydroxychloroquine, captopril and simerprevir antiviral drugs.	Hydroxychloroquine	245-263	angiotensin converting enzyme 2	Homo sapiens	226-230
33706683-3	2021	The results of the docking simulation revealed that methyl-1,4,5-tri-O-cafeoyl quinate has a stronger bond, high affinity and gives the best docking scores compared to, the co-crystallized inhibitor (PRD_002214) of the enzyme ACE2, chloroquine, hydroxychloroquine, captopril and simerprevir antiviral drugs.	Captopril	265-274	angiotensin converting enzyme 2	Homo sapiens	226-230
33706683-3	2021	The results of the docking simulation revealed that methyl-1,4,5-tri-O-cafeoyl quinate has a stronger bond, high affinity and gives the best docking scores compared to, the co-crystallized inhibitor (PRD_002214) of the enzyme ACE2, chloroquine, hydroxychloroquine, captopril and simerprevir antiviral drugs.	simerprevir	279-290	angiotensin converting enzyme 2	Homo sapiens	226-230
33706683-5	2021	The novel MD computational technique study showed better conformational movements result for the methyl-1,4,5-tri-O-cafeoyl quinate-ACE2 docked complex.	methyl-1,4,5-tri-o-cafeoyl quinate	97-131	angiotensin converting enzyme 2	Homo sapiens	132-136
33685364-5	2021	The computational alanine scanning mutation study has recognized the highly stabilized amino acids in the SARS-CoV-2-S RBD/ACE2 complex.	Alanine	18-25	angiotensin converting enzyme 2	Homo sapiens	123-127
32915959-8	2021	RESULTS: In inflamed CD ileum, ACE2 was significantly decreased compared to control ileum (p=4.6E-07), whereas colonic ACE2 was higher in inflamed colon of CD/UC compared to control (p=8.3E-03; p=1.9E-03).	Cadmium	21-23	angiotensin converting enzyme 2	Homo sapiens	31-35
33750821-3	2021	The endosomal acidification inhibitors (8P9R and chloroquine) can synergistically enhance the activity of arbidol, a spike-ACE2 fusion inhibitor, against SARS-CoV-2 and SARS-CoV in cells.	8p9r	40-44	angiotensin converting enzyme 2	Homo sapiens	123-127
33750821-3	2021	The endosomal acidification inhibitors (8P9R and chloroquine) can synergistically enhance the activity of arbidol, a spike-ACE2 fusion inhibitor, against SARS-CoV-2 and SARS-CoV in cells.	Chloroquine	49-60	angiotensin converting enzyme 2	Homo sapiens	123-127
33750821-3	2021	The endosomal acidification inhibitors (8P9R and chloroquine) can synergistically enhance the activity of arbidol, a spike-ACE2 fusion inhibitor, against SARS-CoV-2 and SARS-CoV in cells.	umifenovir	106-113	angiotensin converting enzyme 2	Homo sapiens	123-127
33860009-7	2021	According to the molecular docking binding affinity to block ACE2 receptor, the efficiency mountings were Rhinacanthin D > Flemiflavanone D > Lactupicrin > Exiguaflavanone A > Rhamnetin.	rhinacanthin	106-118	angiotensin converting enzyme 2	Homo sapiens	61-65
33860009-7	2021	According to the molecular docking binding affinity to block ACE2 receptor, the efficiency mountings were Rhinacanthin D > Flemiflavanone D > Lactupicrin > Exiguaflavanone A > Rhamnetin.	flemiflavanone	123-137	angiotensin converting enzyme 2	Homo sapiens	61-65
33860009-7	2021	According to the molecular docking binding affinity to block ACE2 receptor, the efficiency mountings were Rhinacanthin D > Flemiflavanone D > Lactupicrin > Exiguaflavanone A > Rhamnetin.	intybin	142-153	angiotensin converting enzyme 2	Homo sapiens	61-65
33860009-7	2021	According to the molecular docking binding affinity to block ACE2 receptor, the efficiency mountings were Rhinacanthin D > Flemiflavanone D > Lactupicrin > Exiguaflavanone A > Rhamnetin.	exiguaflavanone	156-171	angiotensin converting enzyme 2	Homo sapiens	61-65
33737851-5	2021	More importantly, nicotine in smoking has been hypothesized to downregulate Interleukin-6 (IL-6) which plays a role in COVID-19 severity and to interfere with the Angiotensin-Converting Enzyme 2 (ACE2), the receptor of SARS-CoV-2 led the scientists to experiment nicotine patch prophylactically against COVID-19.	Nicotine	18-26	angiotensin converting enzyme 2	Homo sapiens	163-194
33860009-7	2021	According to the molecular docking binding affinity to block ACE2 receptor, the efficiency mountings were Rhinacanthin D > Flemiflavanone D > Lactupicrin > Exiguaflavanone A > Rhamnetin.	rhamnetin	176-185	angiotensin converting enzyme 2	Homo sapiens	61-65
33897423-0	2021	1,2,3,4,6-Pentagalloyl Glucose, a RBD-ACE2 Binding Inhibitor to Prevent SARS-CoV-2 Infection.	Glucose	23-30	angiotensin converting enzyme 2	Homo sapiens	38-42
33664446-0	2021	Polyunsaturated omega-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding and cellular entry.	polyunsaturated omega-3 fatty acids	0-35	angiotensin converting enzyme 2	Homo sapiens	44-48
33664446-4	2021	In performing target-based ligand screening utilizing the RBD-SARS-CoV-2 sequence, we observed that polyunsaturated fatty acids most effectively interfere with binding to hACE2, the receptor for SARS-CoV-2.	Fatty Acids, Unsaturated	100-127	angiotensin converting enzyme 2	Homo sapiens	171-176
33737851-5	2021	More importantly, nicotine in smoking has been hypothesized to downregulate Interleukin-6 (IL-6) which plays a role in COVID-19 severity and to interfere with the Angiotensin-Converting Enzyme 2 (ACE2), the receptor of SARS-CoV-2 led the scientists to experiment nicotine patch prophylactically against COVID-19.	Nicotine	18-26	angiotensin converting enzyme 2	Homo sapiens	196-200
33084150-5	2021	Molecular docking and molecular dynamics simulations explained why the chemical affinity of the new SARS-CoV-2 for hACE2 is much higher than in the case of SARS-CoV, revealing an intricate pattern of hydrogen bonds and hydrophobic interactions and estimating a free energy of binding, consistently much more negative in the case of SARS-CoV-2.	Hydrogen	200-208	angiotensin converting enzyme 2	Homo sapiens	115-120
33737851-5	2021	More importantly, nicotine in smoking has been hypothesized to downregulate Interleukin-6 (IL-6) which plays a role in COVID-19 severity and to interfere with the Angiotensin-Converting Enzyme 2 (ACE2), the receptor of SARS-CoV-2 led the scientists to experiment nicotine patch prophylactically against COVID-19.	Nicotine	263-271	angiotensin converting enzyme 2	Homo sapiens	163-194
33737851-5	2021	More importantly, nicotine in smoking has been hypothesized to downregulate Interleukin-6 (IL-6) which plays a role in COVID-19 severity and to interfere with the Angiotensin-Converting Enzyme 2 (ACE2), the receptor of SARS-CoV-2 led the scientists to experiment nicotine patch prophylactically against COVID-19.	Nicotine	263-271	angiotensin converting enzyme 2	Homo sapiens	196-200
33755985-2	2021	Angiotensin I Converting Enzyme 2 (ACE2), the principal receptor of SARS-CoV2, has been found to be communicated with Dopa decarboxylase in unwinding the connection of catecholamines with COVID-19 infection.	Catecholamines	168-182	angiotensin converting enzyme 2	Homo sapiens	0-33
33527003-8	2021	Furthermore, 5-beta-glucosyl-7-demethoxy-encecalin (5GDE) and 2-oxocadinan-3,6(11)-dien-12,7-olide (BODO) were found to be potential blockers with excellent binding affinity with Mpro and ACE2 than their native inhibitors remdesivir and hydroxychloroquine respectively.	5-beta-glucosyl-7-demethoxy-encecalin	13-50	angiotensin converting enzyme 2	Homo sapiens	188-192
33527003-8	2021	Furthermore, 5-beta-glucosyl-7-demethoxy-encecalin (5GDE) and 2-oxocadinan-3,6(11)-dien-12,7-olide (BODO) were found to be potential blockers with excellent binding affinity with Mpro and ACE2 than their native inhibitors remdesivir and hydroxychloroquine respectively.	5gde	52-56	angiotensin converting enzyme 2	Homo sapiens	188-192
33527003-8	2021	Furthermore, 5-beta-glucosyl-7-demethoxy-encecalin (5GDE) and 2-oxocadinan-3,6(11)-dien-12,7-olide (BODO) were found to be potential blockers with excellent binding affinity with Mpro and ACE2 than their native inhibitors remdesivir and hydroxychloroquine respectively.	2-oxocadinan-3,6(11)-dien-12,7-olide	62-98	angiotensin converting enzyme 2	Homo sapiens	188-192
33527003-8	2021	Furthermore, 5-beta-glucosyl-7-demethoxy-encecalin (5GDE) and 2-oxocadinan-3,6(11)-dien-12,7-olide (BODO) were found to be potential blockers with excellent binding affinity with Mpro and ACE2 than their native inhibitors remdesivir and hydroxychloroquine respectively.	bodo	100-104	angiotensin converting enzyme 2	Homo sapiens	188-192
32917504-3	2021	We hypothesized that the renal abundance of angiotensin-converting enzyme (ACE) 2, the cell surface receptor for SARS-CoV-2, may be modulated by diabetes and agents that block the renin-angiotensin-aldosterone system (RAAS).	Aldosterone	198-209	angiotensin converting enzyme 2	Homo sapiens	44-81
33755985-2	2021	Angiotensin I Converting Enzyme 2 (ACE2), the principal receptor of SARS-CoV2, has been found to be communicated with Dopa decarboxylase in unwinding the connection of catecholamines with COVID-19 infection.	Catecholamines	168-182	angiotensin converting enzyme 2	Homo sapiens	35-39
33755985-5	2021	The naive form of renal dopaminergic framework is related with the expanded reabsorption of sodium resulting in downregulation of the ACE2 expression.	Sodium	92-98	angiotensin converting enzyme 2	Homo sapiens	134-138
32844337-5	2021	In fact, ACE inhibitors, angiotensin II receptor blockers, and mineralocorticoid antagonists may augment ACE2 levels to protect organs from angiotensin II overload.	inhibitors	13-23	angiotensin converting enzyme 2	Homo sapiens	105-109
33532909-8	2021	SPR analysis confirmed the binding of thymoquinone to ACE2.	thymoquinone	38-50	angiotensin converting enzyme 2	Homo sapiens	54-58
33732940-0	2021	Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction in vitro.	Clioquinol	13-23	angiotensin converting enzyme 2	Homo sapiens	120-124
33732940-0	2021	Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction in vitro.	Clioquinol	13-23	angiotensin converting enzyme 2	Homo sapiens	129-133
33732940-5	2021	In addition, all three compounds showed potent anti-exopeptidase activity against recombinant human angiotensin-converting enzyme 2 (rhACE2) and inhibited the binding of rhACE2 with SARS-CoV-2 Spike (RBD) protein.	rhace2	133-139	angiotensin converting enzyme 2	Homo sapiens	100-131
33748510-5	2021	Over 100 different flavonoids with antioxidant, anti-inflammatory, and antiviral properties from different literatures were taken as a ligand or inhibitor for molecular docking against target protein RBD of nCoV-SP and ACE-2 using PyRX and iGEMDOCK.	Flavonoids	19-29	angiotensin converting enzyme 2	Homo sapiens	219-224
33748510-8	2021	Molecular dynamics simulation studies up to 100 ns exhibited strong binding affinity of selected flavonoids to RBD of nCoV-SP and ACE-2, and the protein-ligand complexes were structurally stable.	Flavonoids	97-107	angiotensin converting enzyme 2	Homo sapiens	130-135
33441437-4	2021	Infection of human ACE2 transgenic mice with SARS-CoV-2 elicited robust responses to H2-Db/N219-227, and 40% of HLA-A*02+ COVID-19 PBMC samples isolated from hospitalized patients responded to this peptide in culture.	Deuterium	85-87	angiotensin converting enzyme 2	Homo sapiens	19-23
33657582-0	2021	Aldosterone and cortisol synthesis regulation by angiotensin-(1-7) and angiotensin-converting enzyme 2 in the human adrenal cortex.	Aldosterone	0-11	angiotensin converting enzyme 2	Homo sapiens	71-102
33657582-0	2021	Aldosterone and cortisol synthesis regulation by angiotensin-(1-7) and angiotensin-converting enzyme 2 in the human adrenal cortex.	Hydrocortisone	16-24	angiotensin converting enzyme 2	Homo sapiens	71-102
32955126-6	2021	The receptor for spike protein of SARS-CoV-2, angiotensin 2 converting enzyme (ACE2), and transmembrane protease serine (for viral entry) are expressed in upper GI enterocytes, ACE2 is expressed on enteroendocrine cells (EECs), and SARS-CoV-2 infects enterocytes but not EECs (studies needed with native EECs).	Serine	113-119	angiotensin converting enzyme 2	Homo sapiens	177-181
33520683-8	2021	Among them, quercetin, one of the most abundant of plant flavonoids, is proposed as a lead candidate with its ability on the virus side to inhibit SARS-CoV spike protein-angiotensin-converting enzyme 2 (ACE2) interaction, viral protease and helicase activities, as well as on the host cell side to inhibit ACE activity and increase intracellular zinc level.	Quercetin	12-21	angiotensin converting enzyme 2	Homo sapiens	203-207
33520683-8	2021	Among them, quercetin, one of the most abundant of plant flavonoids, is proposed as a lead candidate with its ability on the virus side to inhibit SARS-CoV spike protein-angiotensin-converting enzyme 2 (ACE2) interaction, viral protease and helicase activities, as well as on the host cell side to inhibit ACE activity and increase intracellular zinc level.	Flavonoids	57-67	angiotensin converting enzyme 2	Homo sapiens	203-207
33400951-0	2021	Metabolism of angiotensin peptides by angiotensin converting enzyme 2 (ACE2) and analysis of the effect of excess zinc on ACE2 enzymatic activity.	angiotensin peptides	14-34	angiotensin converting enzyme 2	Homo sapiens	38-69
33426364-5	2021	The CVD drugs ACEIs and ARBs, as well as the T2D drugs GLP-1R agonists, were shown to activate angiotensin-converting enzyme 2 (ACE2) expression in experimental animals.	aceis	14-19	angiotensin converting enzyme 2	Homo sapiens	95-126
33426364-5	2021	The CVD drugs ACEIs and ARBs, as well as the T2D drugs GLP-1R agonists, were shown to activate angiotensin-converting enzyme 2 (ACE2) expression in experimental animals.	aceis	14-19	angiotensin converting enzyme 2	Homo sapiens	128-132
33617712-5	2021	We explore the roles played by ACE2 in kidney, cardiovascular, and pulmonary diseases, highlighting studies that defined the benefits imparted when ACEi/ARBs activated the local ACE2- Ang-(1-7)-MasR axis.	acei	148-152	angiotensin converting enzyme 2	Homo sapiens	178-182
33400951-0	2021	Metabolism of angiotensin peptides by angiotensin converting enzyme 2 (ACE2) and analysis of the effect of excess zinc on ACE2 enzymatic activity.	angiotensin peptides	14-34	angiotensin converting enzyme 2	Homo sapiens	71-75
33400951-4	2021	This report compares the ability of recombinant human ACE2 (rhACE2) to metabolize Ang III, Ang IV and Ang V, (4-8 pentapeptide) relative to Ang II to form corresponding des-omega-Phe metabolites.	rhace2	60-66	angiotensin converting enzyme 2	Homo sapiens	54-58
33400951-4	2021	This report compares the ability of recombinant human ACE2 (rhACE2) to metabolize Ang III, Ang IV and Ang V, (4-8 pentapeptide) relative to Ang II to form corresponding des-omega-Phe metabolites.	des-omega-phe	169-182	angiotensin converting enzyme 2	Homo sapiens	54-58
33668910-5	2021	This review emphasises the features of LAB starters and the autochthonous microflora, the biochemistry of dairy food production, and the approaches for achieving the fortification of the foods with prebiotics, bioactive peptides (ACE2-inhibitors, bacteriocins, cyclic peptides with antimicrobial activity), immunomodulatory exopolysaccharides, and other metabolites (indol-3-propionic acid, free amino acids, antioxidants, prebiotics) with reported beneficial effects on human health.	inhibitors	235-245	angiotensin converting enzyme 2	Homo sapiens	230-234
33639976-10	2021	Moreover, in the hACE2 transgenic mice model of SARS-CoV-2 infection, chloroquine and bafilomycin A1 reduced viral replication in lung tissues and alleviated viral pneumonia with reduced inflammatory exudation and infiltration in peribronchiolar and perivascular tissues, as well as improved structures of alveolar septum and pulmonary alveoli.	Chloroquine	70-81	angiotensin converting enzyme 2	Homo sapiens	17-22
33639976-10	2021	Moreover, in the hACE2 transgenic mice model of SARS-CoV-2 infection, chloroquine and bafilomycin A1 reduced viral replication in lung tissues and alleviated viral pneumonia with reduced inflammatory exudation and infiltration in peribronchiolar and perivascular tissues, as well as improved structures of alveolar septum and pulmonary alveoli.	bafilomycin A1	86-100	angiotensin converting enzyme 2	Homo sapiens	17-22
33577324-0	2021	Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19.	kobophenol A	0-12	angiotensin converting enzyme 2	Homo sapiens	38-42
33577324-5	2021	In summary, Kobophenol A, identified through docking studies, is the first compound that inhibits SARS-CoV-2 binding to cells through blocking S1-RBD to the host ACE2 receptor and thus may serve as a good lead compound against COVID-19.	kobophenol	12-22	angiotensin converting enzyme 2	Homo sapiens	162-166
33340519-0	2021	Subtle influence of ACE2 glycan processing on SARS-CoV-2 recognition.	Polysaccharides	25-31	angiotensin converting enzyme 2	Homo sapiens	20-24
33671652-3	2021	In the simulation, peptides of nine to 10 amino acids with a hydrophilic amino acid and acidic amino acid in the middle and aromatic amino acids on the side showed higher binding to angiotensin-converting enzyme 2 (ACE2).	Amino Acids, Aromatic	124-144	angiotensin converting enzyme 2	Homo sapiens	182-213
33671652-3	2021	In the simulation, peptides of nine to 10 amino acids with a hydrophilic amino acid and acidic amino acid in the middle and aromatic amino acids on the side showed higher binding to angiotensin-converting enzyme 2 (ACE2).	Amino Acids, Aromatic	124-144	angiotensin converting enzyme 2	Homo sapiens	215-219
33624300-0	2021	Akt-independent effects of triciribine on ACE2 expression in human lung epithelial cells: Potential benefits in restricting SARS-CoV2 infection.	triciribine	27-38	angiotensin converting enzyme 2	Homo sapiens	42-46
33624300-3	2021	In the current study, we tested the direct effect of TCBN on ACE2 expression in human bronchial (H441) and lung alveolar (A549) epithelial cells.	triciribine	53-57	angiotensin converting enzyme 2	Homo sapiens	61-65
33624300-4	2021	Treatment with TCBN resulted in the downregulation of both messenger RNA and protein levels of ACE2 in A549 cells.	triciribine	15-19	angiotensin converting enzyme 2	Homo sapiens	95-99
33624300-6	2021	We observed increased ACE2 expression with both HMGB1 and hyperglycemia treatment in A549 as well as H441 cells, which were blunted by TCBN treatment.	triciribine	135-139	angiotensin converting enzyme 2	Homo sapiens	22-26
33708781-1	2021	Purpose: On the basis that spironolactone is involved in ACE2 expression and TMPRSS2 activity, previous studies have suggested that spironolactone may influence the infectivity of COVID-19.	Spironolactone	27-41	angiotensin converting enzyme 2	Homo sapiens	57-61
33708781-1	2021	Purpose: On the basis that spironolactone is involved in ACE2 expression and TMPRSS2 activity, previous studies have suggested that spironolactone may influence the infectivity of COVID-19.	Spironolactone	132-146	angiotensin converting enzyme 2	Homo sapiens	57-61
33619331-0	2021	Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2.	Serine	0-6	angiotensin converting enzyme 2	Homo sapiens	107-111
33468620-4	2021	Using an in vitro system, we demonstrate that the small molecule inhibitor ipomoeassin F (Ipom-F) potently blocks the Sec61-mediated ER membrane translocation/insertion of three therapeutic protein targets for SARS-CoV-2 infection; the viral spike and ORF8 proteins together with angiotensin-converting enzyme 2, the host cell plasma membrane receptor.	ipomoeassin F	75-88	angiotensin converting enzyme 2	Homo sapiens	280-311
33468620-4	2021	Using an in vitro system, we demonstrate that the small molecule inhibitor ipomoeassin F (Ipom-F) potently blocks the Sec61-mediated ER membrane translocation/insertion of three therapeutic protein targets for SARS-CoV-2 infection; the viral spike and ORF8 proteins together with angiotensin-converting enzyme 2, the host cell plasma membrane receptor.	ipomoeassin F	90-96	angiotensin converting enzyme 2	Homo sapiens	280-311
33340519-5	2021	We generated a panel of engineered ACE2 glycoforms which were analyzed by mass spectrometry to reveal the site-specific glycan modifications.	Polysaccharides	120-126	angiotensin converting enzyme 2	Homo sapiens	35-39
33340519-6	2021	We then probed the impact of ACE2 glycosylation on S binding and revealed a subtle sensitivity with hypersialylated or oligomannose-type glycans slightly impeding the interaction.	Polysaccharides	137-144	angiotensin converting enzyme 2	Homo sapiens	29-33
33642866-0	2021	Inhibition of ACE2 Expression by Ascorbic Acid Alone and its Combinations with Other Natural Compounds.	Ascorbic Acid	33-46	angiotensin converting enzyme 2	Homo sapiens	14-18
33052059-8	2021	Compared with VAN-treated SHRs, LRAT, retinoic acid receptor alpha (RARalpha), ACE2, and Ang (1-7) protein expression levels were decreased, while ACE and AT1R expression levels were increased in VAD SHRs.	van	14-17	angiotensin converting enzyme 2	Homo sapiens	79-83
33671159-13	2021	First, administering of favipiravir to suppress SARS-CoV-2 and nafamostat to inhibit ACE2 function should be considered.	nafamostat	63-73	angiotensin converting enzyme 2	Homo sapiens	85-89
33587321-7	2021	Oroxylin A exhibited an appreciable suppressive effect against the entrance of the SARS-CoV-2-spiked pseudotyped virus into ACE2 cells, which showed good binding to ACE2 as determined using SPR and CMC.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	0-10	angiotensin converting enzyme 2	Homo sapiens	124-128
33587321-7	2021	Oroxylin A exhibited an appreciable suppressive effect against the entrance of the SARS-CoV-2-spiked pseudotyped virus into ACE2 cells, which showed good binding to ACE2 as determined using SPR and CMC.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	0-10	angiotensin converting enzyme 2	Homo sapiens	165-169
33587321-7	2021	Oroxylin A exhibited an appreciable suppressive effect against the entrance of the SARS-CoV-2-spiked pseudotyped virus into ACE2 cells, which showed good binding to ACE2 as determined using SPR and CMC.	cmc	198-201	angiotensin converting enzyme 2	Homo sapiens	124-128
33587321-7	2021	Oroxylin A exhibited an appreciable suppressive effect against the entrance of the SARS-CoV-2-spiked pseudotyped virus into ACE2 cells, which showed good binding to ACE2 as determined using SPR and CMC.	cmc	198-201	angiotensin converting enzyme 2	Homo sapiens	165-169
33587321-8	2021	Oroxylin A was shown to be a potential candidate in the treatment for COVID-19 by virtue of its blocking the entrance of SARS-CoV-2 into ACE2 cells by specifically binding to the ACE2 receptor.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	0-10	angiotensin converting enzyme 2	Homo sapiens	137-141
33602129-12	2021	CONCLUSION: These results indicated ACE2 rs4646188 was associated with increased risk of AF and CS among diabetic patients in Uygurs, which could be a promising genetic predisposition marker for early and personalized prevention strategies for the aforementioned clinical pathologies.	Cesium	96-98	angiotensin converting enzyme 2	Homo sapiens	36-40
33642866-4	2021	Methods: We tested the effects of ascorbic acid (vitamin C) on cellular expression of ACE2 at the protein and RNA levels in human small alveolar epithelial cells and microvascular endothelial cells.	Ascorbic Acid	34-47	angiotensin converting enzyme 2	Homo sapiens	86-90
33587321-8	2021	Oroxylin A was shown to be a potential candidate in the treatment for COVID-19 by virtue of its blocking the entrance of SARS-CoV-2 into ACE2 cells by specifically binding to the ACE2 receptor.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	0-10	angiotensin converting enzyme 2	Homo sapiens	179-183
33642866-4	2021	Methods: We tested the effects of ascorbic acid (vitamin C) on cellular expression of ACE2 at the protein and RNA levels in human small alveolar epithelial cells and microvascular endothelial cells.	Ascorbic Acid	49-58	angiotensin converting enzyme 2	Homo sapiens	86-90
33642866-5	2021	In addition, we investigated whether combinations of ascorbic acid with other natural compounds can affect ACE2 expression.	Ascorbic Acid	53-66	angiotensin converting enzyme 2	Homo sapiens	107-111
33642866-6	2021	Results: The results show that ascorbic acid itself has moderate but consistent lowering effects on ACE2 expression at the cellular, protein, and RNA levels.	Ascorbic Acid	31-44	angiotensin converting enzyme 2	Homo sapiens	100-104
33642866-7	2021	Some natural compounds were effective in lowering ACE2 cellular expression, with the highest inhibitory effects observed for baicalin (75%) and theaflavin (50%).	baicalin	125-133	angiotensin converting enzyme 2	Homo sapiens	50-54
33642866-7	2021	Some natural compounds were effective in lowering ACE2 cellular expression, with the highest inhibitory effects observed for baicalin (75%) and theaflavin (50%).	theaflavin	144-154	angiotensin converting enzyme 2	Homo sapiens	50-54
33642866-8	2021	Significantly, combinations of these and other test compounds with ascorbic acid further decreased ACE2 expression.	Ascorbic Acid	67-80	angiotensin converting enzyme 2	Homo sapiens	99-103
33642866-9	2021	The highest impact of ascorbate on ACE2 expression was noted when combined with theaflavin (decrease from 50% to 87%), zinc (decrease from 22% to 62%), and with 10-undecenoic acid (from 18% to 53%).	Ascorbic Acid	22-31	angiotensin converting enzyme 2	Homo sapiens	35-39
33642866-9	2021	The highest impact of ascorbate on ACE2 expression was noted when combined with theaflavin (decrease from 50% to 87%), zinc (decrease from 22% to 62%), and with 10-undecenoic acid (from 18% to 53%).	theaflavin	80-90	angiotensin converting enzyme 2	Homo sapiens	35-39
33642866-9	2021	The highest impact of ascorbate on ACE2 expression was noted when combined with theaflavin (decrease from 50% to 87%), zinc (decrease from 22% to 62%), and with 10-undecenoic acid (from 18% to 53%).	undecylenic acid	161-179	angiotensin converting enzyme 2	Homo sapiens	35-39
33533405-8	2021	Here, we summarize the latest pharmacological and genetic tools on regulating ACE/ACE2 balance and highlight the beneficial effects of the ACE2 pathway axis hyperactivity on glycolipid metabolism, as well as the thermogenic modulation.	Glycolipids	174-184	angiotensin converting enzyme 2	Homo sapiens	139-143
33479758-5	2021	Treatment of cultures of human type-II pneumocytes with candesartan or captopril induced up-regulation of ACE2 expression in cells.	candesartan	56-67	angiotensin converting enzyme 2	Homo sapiens	106-110
33479758-5	2021	Treatment of cultures of human type-II pneumocytes with candesartan or captopril induced up-regulation of ACE2 expression in cells.	Captopril	71-80	angiotensin converting enzyme 2	Homo sapiens	106-110
33642866-10	2021	Ascorbic acid showed moderate additional benefits in decreasing ACE2 expression when combined with N-acetylcysteine and baicalin.	Ascorbic Acid	0-13	angiotensin converting enzyme 2	Homo sapiens	64-68
33554856-3	2021	Here, using amide hydrogen-deuterium exchange mass spectrometry and molecular dynamics simulations, we have mapped the S:ACE2 interaction interface and uncovered long-range allosteric propagation of ACE2 binding to sites necessary for host-mediated proteolysis of S protein, critical for viral host entry.	Amides	12-17	angiotensin converting enzyme 2	Homo sapiens	199-203
33594365-7	2021	For the theoretical triple mutant, we demonstrated through Alanine mutations, which help "unglue" key residue-residue interactions, that these three key stabilizing residues could cause the transition of Down to Up protomer states, where the Up protomer state allows binding of the prefusion Spike protein to hACE2 host cell receptors, whereas the Down state is believed inaccessible.	Alanine	59-66	angiotensin converting enzyme 2	Homo sapiens	309-314
33554856-3	2021	Here, using amide hydrogen-deuterium exchange mass spectrometry and molecular dynamics simulations, we have mapped the S:ACE2 interaction interface and uncovered long-range allosteric propagation of ACE2 binding to sites necessary for host-mediated proteolysis of S protein, critical for viral host entry.	Hydrogen	18-26	angiotensin converting enzyme 2	Homo sapiens	199-203
33554856-3	2021	Here, using amide hydrogen-deuterium exchange mass spectrometry and molecular dynamics simulations, we have mapped the S:ACE2 interaction interface and uncovered long-range allosteric propagation of ACE2 binding to sites necessary for host-mediated proteolysis of S protein, critical for viral host entry.	Deuterium	27-36	angiotensin converting enzyme 2	Homo sapiens	199-203
33542252-2	2021	Viral blockade of the angiotensin-converting enzyme 2 impedes degradation of the active kinin des-Arg(9)-bradykinin, which thus increasingly activates bradykinin receptors known to promote inflammation, cough, and edema-symptoms that are commonly observed in COVID-19.	des-arg	94-101	angiotensin converting enzyme 2	Homo sapiens	22-53
33614627-5	2020	The main receptor for SARS-CoV-2 is represented by the angiotensin-converting enzyme-2 (ACE-2), although it also binds to sialic acids linked to host cell surface gangliosides.	Sialic Acids	122-134	angiotensin converting enzyme 2	Homo sapiens	55-86
33614627-5	2020	The main receptor for SARS-CoV-2 is represented by the angiotensin-converting enzyme-2 (ACE-2), although it also binds to sialic acids linked to host cell surface gangliosides.	Sialic Acids	122-134	angiotensin converting enzyme 2	Homo sapiens	88-93
33614627-5	2020	The main receptor for SARS-CoV-2 is represented by the angiotensin-converting enzyme-2 (ACE-2), although it also binds to sialic acids linked to host cell surface gangliosides.	Gangliosides	163-175	angiotensin converting enzyme 2	Homo sapiens	55-86
33614627-5	2020	The main receptor for SARS-CoV-2 is represented by the angiotensin-converting enzyme-2 (ACE-2), although it also binds to sialic acids linked to host cell surface gangliosides.	Gangliosides	163-175	angiotensin converting enzyme 2	Homo sapiens	88-93
33563197-4	2021	Even though ACE-2 is significant in the renin-angiotensin-aldosterone system (RAAS) regulation that exhibits protection to various organs, they play a significant role in COVID-19 disease pathogenesis.	Aldosterone	58-69	angiotensin converting enzyme 2	Homo sapiens	12-17
33564771-5	2021	Modeling analysis showed that the N501Y mutation would allow a potential aromatic ring-ring interaction and an additional hydrogen bond between the RBD and ACE2.	Hydrogen	122-130	angiotensin converting enzyme 2	Homo sapiens	156-160
33564767-7	2021	As an example of the latter, analyses of strepsirrhine primate ACE2 sequences to date indicate large variation among lemurs and lorises compared to other primate clades despite low sampling effort.	strepsirrhine	41-54	angiotensin converting enzyme 2	Homo sapiens	63-67
33552834-4	2021	Our comprehensive structure analysis revealed that the natural substitution of amino acid residues Gln24, His34, Phe40, Leu79 and Met82 in the N-terminal alpha1 and alpha2 helices of the ACE2 receptor results in loss of crucial network of hydrogen-bonded and hydrophobic interactions with receptor binding domain of SARS-CoV-2 spike protein.	Hydrogen	239-247	angiotensin converting enzyme 2	Homo sapiens	187-191
33552834-5	2021	Another striking observation is the absence of N-glycosylation site Asn103 in all mammals and many species, lack more than one N-linked glycosylation site in the ACE2 receptor.	Nitrogen	127-128	angiotensin converting enzyme 2	Homo sapiens	162-166
33629340-9	2021	RESULTS: We noted that the molecular interaction of SARS-CoV-2 S gp and hACE2 form eleven hydrogen bonds, while the molecular interaction of SARS-CoV S gp and hACE2 receptor form seven hydrogen bonds, indicating that the molecular interaction of SARS-CoV-2 S gp and hACE2 receptor is more stable than SARS-CoV S gp and hACE2 receptor.	Hydrogen	90-98	angiotensin converting enzyme 2	Homo sapiens	159-164
33125711-8	2021	Mechanistically we observed that heparin binds and destabilizes the RBD protein, and furthermore we show heparin directly inhibits the binding of RBD to the human ACE2 protein receptor.	Heparin	33-40	angiotensin converting enzyme 2	Homo sapiens	163-167
33125711-8	2021	Mechanistically we observed that heparin binds and destabilizes the RBD protein, and furthermore we show heparin directly inhibits the binding of RBD to the human ACE2 protein receptor.	Heparin	105-112	angiotensin converting enzyme 2	Homo sapiens	163-167
33125711-10	2021	UFH acts to directly inhibit binding of spike protein to the human ACE2 protein receptor.	Heparin	0-3	angiotensin converting enzyme 2	Homo sapiens	67-71
33401173-2	2021	Using computational simulation, blockade mechanism of SARS-CoV-2 spike receptor binding domain (S RBD) and human angiotensin converting enzyme 2 (hACE2) was clarified based on interactions between RBD and hesperidin.	Hesperidin	205-215	angiotensin converting enzyme 2	Homo sapiens	113-144
33401173-2	2021	Using computational simulation, blockade mechanism of SARS-CoV-2 spike receptor binding domain (S RBD) and human angiotensin converting enzyme 2 (hACE2) was clarified based on interactions between RBD and hesperidin.	Hesperidin	205-215	angiotensin converting enzyme 2	Homo sapiens	146-151
33401173-4	2021	An anti-SARS-CoV-2 drug screening strategy based on blocking S RBD/hACE2 binding was established according to the first key change (interactions between hesperidin and S RBD/hACE2) vs the second key change (interactions between anti-SARS-CoV-2 drugs and RBD/hACE2) trends.	Hesperidin	153-163	angiotensin converting enzyme 2	Homo sapiens	67-72
33629340-9	2021	RESULTS: We noted that the molecular interaction of SARS-CoV-2 S gp and hACE2 form eleven hydrogen bonds, while the molecular interaction of SARS-CoV S gp and hACE2 receptor form seven hydrogen bonds, indicating that the molecular interaction of SARS-CoV-2 S gp and hACE2 receptor is more stable than SARS-CoV S gp and hACE2 receptor.	Hydrogen	90-98	angiotensin converting enzyme 2	Homo sapiens	72-77
33629340-9	2021	RESULTS: We noted that the molecular interaction of SARS-CoV-2 S gp and hACE2 form eleven hydrogen bonds, while the molecular interaction of SARS-CoV S gp and hACE2 receptor form seven hydrogen bonds, indicating that the molecular interaction of SARS-CoV-2 S gp and hACE2 receptor is more stable than SARS-CoV S gp and hACE2 receptor.	Hydrogen	90-98	angiotensin converting enzyme 2	Homo sapiens	159-164
33629340-9	2021	RESULTS: We noted that the molecular interaction of SARS-CoV-2 S gp and hACE2 form eleven hydrogen bonds, while the molecular interaction of SARS-CoV S gp and hACE2 receptor form seven hydrogen bonds, indicating that the molecular interaction of SARS-CoV-2 S gp and hACE2 receptor is more stable than SARS-CoV S gp and hACE2 receptor.	Hydrogen	90-98	angiotensin converting enzyme 2	Homo sapiens	159-164
33629340-9	2021	RESULTS: We noted that the molecular interaction of SARS-CoV-2 S gp and hACE2 form eleven hydrogen bonds, while the molecular interaction of SARS-CoV S gp and hACE2 receptor form seven hydrogen bonds, indicating that the molecular interaction of SARS-CoV-2 S gp and hACE2 receptor is more stable than SARS-CoV S gp and hACE2 receptor.	Hydrogen	185-193	angiotensin converting enzyme 2	Homo sapiens	159-164
33629340-9	2021	RESULTS: We noted that the molecular interaction of SARS-CoV-2 S gp and hACE2 form eleven hydrogen bonds, while the molecular interaction of SARS-CoV S gp and hACE2 receptor form seven hydrogen bonds, indicating that the molecular interaction of SARS-CoV-2 S gp and hACE2 receptor is more stable than SARS-CoV S gp and hACE2 receptor.	Hydrogen	185-193	angiotensin converting enzyme 2	Homo sapiens	159-164
33629340-9	2021	RESULTS: We noted that the molecular interaction of SARS-CoV-2 S gp and hACE2 form eleven hydrogen bonds, while the molecular interaction of SARS-CoV S gp and hACE2 receptor form seven hydrogen bonds, indicating that the molecular interaction of SARS-CoV-2 S gp and hACE2 receptor is more stable than SARS-CoV S gp and hACE2 receptor.	Hydrogen	185-193	angiotensin converting enzyme 2	Homo sapiens	159-164
33443816-4	2021	A large number of studies have shown that ACE2 can reverse myocardial injury in various cardiovascular diseases (CVDs) as well as is exert anti-inflammatory, antioxidant, anti-apoptotic and anticardiomyocyte fibrosis effects by regulating transforming growth factor beta, mitogen-activated protein kinases, calcium ions in cells and other major pathways.	Calcium	307-314	angiotensin converting enzyme 2	Homo sapiens	42-46
33290594-6	2021	ACEIs and ARBs may increase the amount of ACE-2 formation and, theoretically, increase the risk of SARS-CoV-2 entry into cells, thus inducing inflammation [2].	aceis	0-5	angiotensin converting enzyme 2	Homo sapiens	42-47
33526003-0	2021	Flavonol morin targets host ACE2, IMP-alpha, PARP-1 and viral proteins of SARS-CoV-2, SARS-CoV and MERS-CoV critical for infection and survival: a computational analysis.	3-hydroxyflavone	0-8	angiotensin converting enzyme 2	Homo sapiens	28-32
32770567-7	2021	Moreover, out of three distinct binding sites (I, II and III) of spike core when HCQ binds only with site III (farthest from the nCoV-RBD of ACE2 contact), epigallocatechin gallate and theaflavin gallate bind all three sites.	Hydroxychloroquine	81-84	angiotensin converting enzyme 2	Homo sapiens	141-145
33103220-6	2021	Out of six drugs characterized as putative RBD binders, the cephalosporin antibiotic cefsulodin was further assessed for its effect on the binding between the RBD and ACE2, suggesting that it is important to consider the dynamic formation of the heterodimer between RBD and ACE2 when judging any potential candidate.	Cephalosporins	60-73	angiotensin converting enzyme 2	Homo sapiens	167-171
33103220-6	2021	Out of six drugs characterized as putative RBD binders, the cephalosporin antibiotic cefsulodin was further assessed for its effect on the binding between the RBD and ACE2, suggesting that it is important to consider the dynamic formation of the heterodimer between RBD and ACE2 when judging any potential candidate.	Cephalosporins	60-73	angiotensin converting enzyme 2	Homo sapiens	274-278
33103220-6	2021	Out of six drugs characterized as putative RBD binders, the cephalosporin antibiotic cefsulodin was further assessed for its effect on the binding between the RBD and ACE2, suggesting that it is important to consider the dynamic formation of the heterodimer between RBD and ACE2 when judging any potential candidate.	Cefsulodin	85-95	angiotensin converting enzyme 2	Homo sapiens	167-171
33310043-6	2021	KEY FINDINGS: After the CMC screening, 8 of the 19 APDs were well-retained on ACE2-HEK293T/CMC column and showed significant antiviral activities in vitro.	cmc	24-27	angiotensin converting enzyme 2	Homo sapiens	78-82
33103220-6	2021	Out of six drugs characterized as putative RBD binders, the cephalosporin antibiotic cefsulodin was further assessed for its effect on the binding between the RBD and ACE2, suggesting that it is important to consider the dynamic formation of the heterodimer between RBD and ACE2 when judging any potential candidate.	Cefsulodin	85-95	angiotensin converting enzyme 2	Homo sapiens	274-278
33462852-5	2021	A better understanding of the endocrinology of the disease, in particular the neuroendocrinology of ACE2 during COVID-19, may contribute to the timely design of new therapeutic strategies, including the regulation of ACE2 itself by steroid hormones, to ameliorate the severity of COVID-19.	Steroids	232-239	angiotensin converting enzyme 2	Homo sapiens	217-221
33493919-10	2021	Thus, ZINC33039472 is identified to be a promising interfacial binding molecule which can inhibit the interaction between the viral S protein and human ACE2 receptor which would consequently help in the management of the disease.	zinc33039472	6-18	angiotensin converting enzyme 2	Homo sapiens	152-156
33523654-5	2022	Challenge studies in both an AAV-hACE2 mouse model of SARS-CoV-2 and in mice infected with murine hepatitis virus, a closely related coronavirus, showed that GS-441524 was highly efficacious in reducing the viral titers in CoV-infected organs without notable toxicity.	GS-441524	158-167	angiotensin converting enzyme 2	Homo sapiens	33-38
33310043-6	2021	KEY FINDINGS: After the CMC screening, 8 of the 19 APDs were well-retained on ACE2-HEK293T/CMC column and showed significant antiviral activities in vitro.	cmc	91-94	angiotensin converting enzyme 2	Homo sapiens	78-82
33310043-7	2021	Three quarters of them belong to phenothiazine and could significantly inhibit the entrance of coronavirus into ACE2-HEK293T cells.	phenothiazine	33-46	angiotensin converting enzyme 2	Homo sapiens	112-116
32902005-7	2021	The most recently published papers on the distribution of ACE2 in the human body and documented binding of GZ to this receptor, as well as its antiviral activity, suggest that GZ can be used as a therapeutic for COVID-19 and as a preventive agent against SARS-CoV-2.	Glycyrrhizic Acid	176-178	angiotensin converting enzyme 2	Homo sapiens	58-62
33275540-4	2021	ACE2 is crucial for maintaining tissue homeostasis and negatively regulates the renin-angiotensin-aldosterone system (RAAS) in the humans.	Aldosterone	98-109	angiotensin converting enzyme 2	Homo sapiens	0-4
32851697-6	2021	In human TE data, 54.4% of TE1 cells, 9.0% of CTBs, 3.2% of EVTs and 29.5% of STBs were ACE2 positive.	stbs	78-82	angiotensin converting enzyme 2	Homo sapiens	88-92
32691370-1	2021	Angiotensin-converting enzyme 2 (ACE2) plays an important role as a member of the renin-angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II (Ang II) into angiotensin (1-7) (Ang [1-7]).	Aldosterone	100-111	angiotensin converting enzyme 2	Homo sapiens	0-31
32691370-1	2021	Angiotensin-converting enzyme 2 (ACE2) plays an important role as a member of the renin-angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II (Ang II) into angiotensin (1-7) (Ang [1-7]).	Aldosterone	100-111	angiotensin converting enzyme 2	Homo sapiens	33-37
33387788-0	2021	Dexamethasone inhibits SARS-CoV-2 spike pseudotyped virus viropexis by binding to ACE2.	Dexamethasone	0-13	angiotensin converting enzyme 2	Homo sapiens	82-86
33309272-7	2021	Although mechanisms by which specific antihistamines exert antiviral effects is not clear, hydroxyzine, and possibly azelastine, bind Angiotensin Converting Enzyme-2 (ACE2) and the sigma-1 receptor as off-targets.	Hydroxyzine	91-102	angiotensin converting enzyme 2	Homo sapiens	134-165
33387788-4	2021	Molecular docking results revealed that DEX occupied with active binding site of ACE2 of SARS-CoV-2 spike protein.	Dexamethasone	40-43	angiotensin converting enzyme 2	Homo sapiens	81-85
33387788-5	2021	Surface plasmon resonance (SPR) results showed that KD value between DEX and ACE2 was (9.03 +- 0.78) e-6 M. Cell membrane chromatography (CMC) results uncovered that DEX had a chromatographic retention.	Dexamethasone	69-72	angiotensin converting enzyme 2	Homo sapiens	77-81
33387788-5	2021	Surface plasmon resonance (SPR) results showed that KD value between DEX and ACE2 was (9.03 +- 0.78) e-6 M. Cell membrane chromatography (CMC) results uncovered that DEX had a chromatographic retention.	Dexamethasone	166-169	angiotensin converting enzyme 2	Homo sapiens	77-81
33387788-6	2021	DEX was found out to inhibiting the viropexis into ACE2h cells using SARS-CoV-2 spike pseudotyped virus.	Dexamethasone	0-3	angiotensin converting enzyme 2	Homo sapiens	51-55
33387788-7	2021	Therefore, DEX inhibits the entrance of SARS-CoV-2 spike pseudotyped virus into cell by binding to ACE2.	Dexamethasone	11-14	angiotensin converting enzyme 2	Homo sapiens	99-103
33309272-7	2021	Although mechanisms by which specific antihistamines exert antiviral effects is not clear, hydroxyzine, and possibly azelastine, bind Angiotensin Converting Enzyme-2 (ACE2) and the sigma-1 receptor as off-targets.	Hydroxyzine	91-102	angiotensin converting enzyme 2	Homo sapiens	167-171
33309272-7	2021	Although mechanisms by which specific antihistamines exert antiviral effects is not clear, hydroxyzine, and possibly azelastine, bind Angiotensin Converting Enzyme-2 (ACE2) and the sigma-1 receptor as off-targets.	azelastine	117-127	angiotensin converting enzyme 2	Homo sapiens	134-165
33309272-7	2021	Although mechanisms by which specific antihistamines exert antiviral effects is not clear, hydroxyzine, and possibly azelastine, bind Angiotensin Converting Enzyme-2 (ACE2) and the sigma-1 receptor as off-targets.	azelastine	117-127	angiotensin converting enzyme 2	Homo sapiens	167-171
33511992-6	2021	In endothelial cells activation of the ACE2/Ang-(1-7)/Mas1 axis increases production of the vasodilator"s nitric oxide and prostacyclin"s and in vascular smooth muscle cells it inhibits pro-contractile and pro-inflammatory signaling.	Nitric Oxide	106-118	angiotensin converting enzyme 2	Homo sapiens	39-43
33602511-10	2021	Reorientation of several crucial residues at the RBD-ACE2 interface facilitates additional hydrogen bond formation for the V367F variant which enhances the binding energy during ACE2 recognition.	Hydrogen	91-99	angiotensin converting enzyme 2	Homo sapiens	53-57
33602511-10	2021	Reorientation of several crucial residues at the RBD-ACE2 interface facilitates additional hydrogen bond formation for the V367F variant which enhances the binding energy during ACE2 recognition.	Hydrogen	91-99	angiotensin converting enzyme 2	Homo sapiens	178-182
33580917-7	2021	The disruption of ACE2 impairs leads to intestinal inflammation and decreased synthesis of serotonin, affecting motility.	Serotonin	91-100	angiotensin converting enzyme 2	Homo sapiens	18-22
33511992-6	2021	In endothelial cells activation of the ACE2/Ang-(1-7)/Mas1 axis increases production of the vasodilator"s nitric oxide and prostacyclin"s and in vascular smooth muscle cells it inhibits pro-contractile and pro-inflammatory signaling.	Epoprostenol	123-135	angiotensin converting enzyme 2	Homo sapiens	39-43
33525682-9	2021	Collectively, our findings highlighted the potential of iPSC-derived retinal organoids as the models for ACE2 receptor-based SARS-CoV-2 infection.	Retinaldehyde	69-76	angiotensin converting enzyme 2	Homo sapiens	105-109
33514685-0	2021	Engaging the spikes: heparan sulfate facilitates SARS-CoV-2 spike protein binding to ACE2 and potentiates viral infection.	Heparitin Sulfate	21-36	angiotensin converting enzyme 2	Homo sapiens	85-89
33481336-3	2021	Human ACE2 is heavily glycosylated and its glycans impact on binding to the SARS-CoV-2 spike protein and virus infectivity.	Polysaccharides	43-50	angiotensin converting enzyme 2	Homo sapiens	6-10
33525682-0	2021	Expression of Endogenous Angiotensin-Converting Enzyme 2 in Human Induced Pluripotent Stem Cell-Derived Retinal Organoids.	Retinaldehyde	104-111	angiotensin converting enzyme 2	Homo sapiens	25-56
33584343-4	2021	ACE2 has extensive biological activities as a component of the renin-angiotensin-aldosterone system (RAAS) and plays a pivotal role as counter-regulator of angiotensin II (Ang II) activity by converting the latter to Ang (1-7).	Aldosterone	81-92	angiotensin converting enzyme 2	Homo sapiens	0-4
33532775-5	2021	Sb68 interacts peripherally at the ACE2 interface; steric clashes with glycans explain its mechanism of viral neutralization.	sb68	0-4	angiotensin converting enzyme 2	Homo sapiens	35-39
33387885-9	2021	N-(4[(2E)-3-(4-dimetilaminophenyl)-1-(phenyl)-prop-2-en-1-one]) acetamide (PAAPA) chalcone had a better affinity with ACE2, with strong hydrogen interactions.	n-(4[(2e)-3-(4-dimetilaminophenyl)-1-(phenyl)-prop-2-en-1-one]) acetamide	0-73	angiotensin converting enzyme 2	Homo sapiens	118-122
33387885-9	2021	N-(4[(2E)-3-(4-dimetilaminophenyl)-1-(phenyl)-prop-2-en-1-one]) acetamide (PAAPA) chalcone had a better affinity with ACE2, with strong hydrogen interactions.	9-(3-phenylalanylamidopropyl)adenine	75-80	angiotensin converting enzyme 2	Homo sapiens	118-122
33573088-4	2021	Moreover, it was found that linoleic acid, an omega-6 PUFA, could stabilize the spike protein in a closed conformation, blocking its interaction with ACE2.	Linoleic Acid	28-41	angiotensin converting enzyme 2	Homo sapiens	150-154
33491580-8	2021	Molecular dynamics simulation (MDS) was performed to observe behavior and interaction of potential drug hydrazinocurcumin against target proteins ACE-2 and PAR-1.	hydrazinocurcumin	104-121	angiotensin converting enzyme 2	Homo sapiens	146-151
33387885-5	2021	The present work evaluated, through molecular docking assays, the interactions of 4"-acetamidechalcones with enzymatic and structural targets of SARS-CoV-2 and with the host"s ACE2, which is recognized by the virus, facilitating its entry into cells.	4"-acetamidechalcones	82-103	angiotensin converting enzyme 2	Homo sapiens	176-180
33387885-9	2021	N-(4[(2E)-3-(4-dimetilaminophenyl)-1-(phenyl)-prop-2-en-1-one]) acetamide (PAAPA) chalcone had a better affinity with ACE2, with strong hydrogen interactions.	Chalcone	82-90	angiotensin converting enzyme 2	Homo sapiens	118-122
33481336-5	2021	Our data reveal that the produced dimeric ACE2-Fc variant is glycosylated with mainly complex human-type N-glycans and functional with regard to enzyme activity, affinity to the SARS-CoV-2 receptor-binding domain (RBD) and wild-type virus neutralization.	n-glycans	105-114	angiotensin converting enzyme 2	Homo sapiens	42-46
33387885-9	2021	N-(4[(2E)-3-(4-dimetilaminophenyl)-1-(phenyl)-prop-2-en-1-one]) acetamide (PAAPA) chalcone had a better affinity with ACE2, with strong hydrogen interactions.	Hydrogen	136-144	angiotensin converting enzyme 2	Homo sapiens	118-122
33387885-10	2021	Together, our results suggest that 4"-acetamidechalcones inhibit the interaction of the virus with host cells through binding to ACE2 or SPIKE protein, probably generating a steric impediment.	4"-acetamidechalcones	35-56	angiotensin converting enzyme 2	Homo sapiens	129-133
33475077-3	2021	OBJECTIVE: The purpose of this review is to discuss the existing evidence on the interaction between COVID-19 infection, ACE2 and ACEIs or ARBs and to examine the main implications for clinical practice.	aceis	130-135	angiotensin converting enzyme 2	Homo sapiens	121-125
33479401-0	2021	Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies.	Catechin	0-8	angiotensin converting enzyme 2	Homo sapiens	63-67
33479401-0	2021	Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies.	Curcumin	13-21	angiotensin converting enzyme 2	Homo sapiens	63-67
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Catechin	57-65	angiotensin converting enzyme 2	Homo sapiens	158-162
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Catechin	57-65	angiotensin converting enzyme 2	Homo sapiens	258-262
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Catechin	57-65	angiotensin converting enzyme 2	Homo sapiens	258-262
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Curcumin	70-78	angiotensin converting enzyme 2	Homo sapiens	158-162
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Curcumin	70-78	angiotensin converting enzyme 2	Homo sapiens	258-262
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Curcumin	70-78	angiotensin converting enzyme 2	Homo sapiens	258-262
33479401-5	2021	The binding affinity values of catechin and curcumin for the S protein, ACE2 and RBD/ACE2-complex are - 10.5 and - 7.9 kcal/mol; - 8.9 and - 7.8 kcal/mol; and - 9.1 and - 7.6 kcal/mol, respectively.	Catechin	31-39	angiotensin converting enzyme 2	Homo sapiens	72-76
33479401-5	2021	The binding affinity values of catechin and curcumin for the S protein, ACE2 and RBD/ACE2-complex are - 10.5 and - 7.9 kcal/mol; - 8.9 and - 7.8 kcal/mol; and - 9.1 and - 7.6 kcal/mol, respectively.	Catechin	31-39	angiotensin converting enzyme 2	Homo sapiens	85-89
33479401-5	2021	The binding affinity values of catechin and curcumin for the S protein, ACE2 and RBD/ACE2-complex are - 10.5 and - 7.9 kcal/mol; - 8.9 and - 7.8 kcal/mol; and - 9.1 and - 7.6 kcal/mol, respectively.	Curcumin	44-52	angiotensin converting enzyme 2	Homo sapiens	72-76
33479401-5	2021	The binding affinity values of catechin and curcumin for the S protein, ACE2 and RBD/ACE2-complex are - 10.5 and - 7.9 kcal/mol; - 8.9 and - 7.8 kcal/mol; and - 9.1 and - 7.6 kcal/mol, respectively.	Curcumin	44-52	angiotensin converting enzyme 2	Homo sapiens	85-89
33356169-10	2021	Results from the infection experiments and modeling of the peptides with Spike RBD identified a 6-amino-acid (Glu37-Gln42) ACE2 motif that is important for SARS-CoV-2 inhibition.	6-amino-acid	96-108	angiotensin converting enzyme 2	Homo sapiens	123-127
33479401-9	2021	Both catechin and curcumin bind the interface of "RBD/ACE2-complex" and intervene in causing fluctuation of the alpha helices and beta-strands of the protein complex.	Catechin	5-13	angiotensin converting enzyme 2	Homo sapiens	54-58
33479401-9	2021	Both catechin and curcumin bind the interface of "RBD/ACE2-complex" and intervene in causing fluctuation of the alpha helices and beta-strands of the protein complex.	Curcumin	18-26	angiotensin converting enzyme 2	Homo sapiens	54-58
33479401-10	2021	Protein-protein interaction studies in presence of curcumin or catechin also corroborate the above findings suggesting the efficacy of these two polyphenols in hindering the formation of S Protein-ACE2 complex.	Curcumin	51-59	angiotensin converting enzyme 2	Homo sapiens	197-201
33479401-10	2021	Protein-protein interaction studies in presence of curcumin or catechin also corroborate the above findings suggesting the efficacy of these two polyphenols in hindering the formation of S Protein-ACE2 complex.	Catechin	63-71	angiotensin converting enzyme 2	Homo sapiens	197-201
33519467-0	2020	3-Hydroxyphthalic Anhydride-Modified Chicken Ovalbumin as a Potential Candidate Inhibits SARS-CoV-2 Infection by Disrupting the Interaction of Spike Protein With Host ACE2 Receptor.	3-hydroxyphthalic anhydride	0-27	angiotensin converting enzyme 2	Homo sapiens	167-171
33479401-10	2021	Protein-protein interaction studies in presence of curcumin or catechin also corroborate the above findings suggesting the efficacy of these two polyphenols in hindering the formation of S Protein-ACE2 complex.	Polyphenols	145-156	angiotensin converting enzyme 2	Homo sapiens	197-201
33498183-5	2021	Recognition of carbohydrate moieties clustered on the surface of the S protein may drive receptor-dependent internalization, accentuate severe immunopathological inflammation, and allow for systemic spread of infection, independent of ACE2.	Carbohydrates	15-27	angiotensin converting enzyme 2	Homo sapiens	235-239
33501438-6	2021	Our recent analysis of the highly transmissible N501Y lineage B.1.1.7 mutation in SARS-CoV-2 also supports this model, identifying a less promiscuous Y501 interaction with ACE2 that favors more stable functional binding with the K353 site alone.	Fluoroglycofen	229-233	angiotensin converting enzyme 2	Homo sapiens	172-176
33477294-10	2021	It has been proposed that spironolactone may prevent acute lung injury in COVID-19 infection due to its pleiotropic effects with favorable renin-angiotensin-aldosterone system (RAAS) and ACE2 expression, reduction in transmembrane serine protease 2 (TMPRSS2) activity and antiandrogenic action, and therefore it may prove to act as additional protection for patients at highest risk of severe pneumonia.	Spironolactone	26-40	angiotensin converting enzyme 2	Homo sapiens	187-191
33249077-0	2021	Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin-converting enzyme II receptor (ACE2).	Flavonols	0-9	angiotensin converting enzyme 2	Homo sapiens	188-192
33452303-5	2021	After analyzing TCGS data, 570 genetic variations on the ACE2 gene, including single nucleotide polymorphisms (SNP) and insertion/deletion (INDEL) were detected.	tcgs	16-20	angiotensin converting enzyme 2	Homo sapiens	57-61
33444408-6	2021	Quercetin may also serve as SARS-CoV-2 inhibitor by binding with the active sites of SARS-CoV-2 main protease 3CL and ACE2, therefore suppressing the functions of the proteins to cut the viral life cycle.	Quercetin	0-9	angiotensin converting enzyme 2	Homo sapiens	118-122
33439057-5	2021	Moreover, blockage of ACE2 aided angiotensin II into angiotensin (1-7) conversion may also affect testosterone synthesis.	Testosterone	98-110	angiotensin converting enzyme 2	Homo sapiens	22-26
33446655-4	2021	In mice, low-dose NVX-CoV2373 with saponin-based Matrix-M adjuvant elicit high titer anti-S IgG that blocks hACE2 receptor binding, neutralize virus, and protects against SARS-CoV-2 challenge with no evidence of vaccine-associated enhanced respiratory disease.	Saponins	35-42	angiotensin converting enzyme 2	Homo sapiens	108-113
33446655-4	2021	In mice, low-dose NVX-CoV2373 with saponin-based Matrix-M adjuvant elicit high titer anti-S IgG that blocks hACE2 receptor binding, neutralize virus, and protects against SARS-CoV-2 challenge with no evidence of vaccine-associated enhanced respiratory disease.	Bis[2-(4-azidosalicylamido)ethyl] disulfide	43-48	angiotensin converting enzyme 2	Homo sapiens	108-113
33173010-4	2021	In addition to its well-documented interaction with its receptor, human angiotensin converting enzyme 2 (hACE2), SGP has been found to bind to glycosaminoglycans like heparan sulfate, which is found on the surface of virtually all mammalian cells.	Heparitin Sulfate	167-182	angiotensin converting enzyme 2	Homo sapiens	72-103
33519460-0	2020	Methylene Blue Inhibits the SARS-CoV-2 Spike-ACE2 Protein-Protein Interaction-a Mechanism that can Contribute to its Antiviral Activity Against COVID-19.	Methylene Blue	0-14	angiotensin converting enzyme 2	Homo sapiens	45-49
33519460-5	2020	Methylene blue inhibited the entry of a SARS-CoV-2 spike bearing pseudovirus into ACE2-expressing cells with similar IC50 (3.5 muM).	Methylene Blue	0-14	angiotensin converting enzyme 2	Homo sapiens	82-86
33173010-4	2021	In addition to its well-documented interaction with its receptor, human angiotensin converting enzyme 2 (hACE2), SGP has been found to bind to glycosaminoglycans like heparan sulfate, which is found on the surface of virtually all mammalian cells.	Heparitin Sulfate	167-182	angiotensin converting enzyme 2	Homo sapiens	105-110
33179852-0	2021	Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection.	remdesivir	42-52	angiotensin converting enzyme 2	Homo sapiens	14-18
33511147-7	2020	Results: Mining information from the GEO database showed that compared with healthy control, intestinal ACE2 expression was downregulated in ileum of CD patients, while upregulated in colon of both CD and UC patients.	Cadmium	150-152	angiotensin converting enzyme 2	Homo sapiens	104-108
33420022-4	2021	Next, we show that sialic acids present on ACE2 prevent efficient spike/ACE2-interaction.	Sialic Acids	19-31	angiotensin converting enzyme 2	Homo sapiens	43-47
32679589-4	2021	Vitamin D can induce the expression of angiotensin-converting enzyme 2 and regulate the immune system through different mechanisms.	Vitamin D	0-9	angiotensin converting enzyme 2	Homo sapiens	39-70
33420022-4	2021	Next, we show that sialic acids present on ACE2 prevent efficient spike/ACE2-interaction.	Sialic Acids	19-31	angiotensin converting enzyme 2	Homo sapiens	72-76
33413387-6	2021	In multivariate analyses, sputum ACE2 levels were positively associated with OCS use and male gender.	L-Cysteic acid	77-80	angiotensin converting enzyme 2	Homo sapiens	33-37
33409846-7	2021	SARS-CoV-2, by using the well-known angiotensin-converting enzyme 2 by the protein spike, as the host receptor to enter into alveolar, myocardial, and renal epithelial cells, can be disrupted by vitamin D.	Vitamin D	195-204	angiotensin converting enzyme 2	Homo sapiens	36-67
33039544-3	2021	Incidentally, the renin-angiotensin-aldosterone system (RAAS) is integral to physiologic control of both ACE and ACE2 expression, and is an essential system utilized by SARS-CoV-2, albeit with varying schools of thought on how it can affect viral entry.	Aldosterone	36-47	angiotensin converting enzyme 2	Homo sapiens	113-117
33398633-6	2021	Among them, beta-sitosterol was found with the highest binding affinity - 12.2 kcal/mol and stable interactions with the amino acid residues present on the active site of the ACE-2 receptor.	gamma-sitosterol	12-27	angiotensin converting enzyme 2	Homo sapiens	175-180
33389440-11	2022	The aptamer is also predicted to be non-antigenic, non-allergenic, non-hemolytic, non-inflammatory, water-soluble with high affinity toward ACE2 than serum albumin.	Water	100-105	angiotensin converting enzyme 2	Homo sapiens	140-144
33130382-2	2021	Among the eight nisin variants examined, nisin H, nisin Z, nisin U and nisin A showed a significant binding affinity towards hACE2, higher than that of the RBD (receptor binding domain) of the SARS-CoV-2 spike protein.	nisin u	59-66	angiotensin converting enzyme 2	Homo sapiens	125-130
33072499-6	2021	Results show that rhein, forsythoside A, forsythoside I, neochlorogenic acid and its isomers exhibited high inhibitory effect on ACE2.	forsythiaside	25-39	angiotensin converting enzyme 2	Homo sapiens	129-133
33130382-4	2021	Further, binding efficiency of the most potent nisin H was evaluated through the interaction of hACE2:nisin H complex with RBD (receptor-binding domain) of SARS-CoV-2 and that of hACE2:RBD complex with nisin H. Here, nisin H acted as a potential competitor of RBD to access the hACE2 receptor.	nisin h	47-54	angiotensin converting enzyme 2	Homo sapiens	96-101
33072499-6	2021	Results show that rhein, forsythoside A, forsythoside I, neochlorogenic acid and its isomers exhibited high inhibitory effect on ACE2.	isoforsythiaside	41-55	angiotensin converting enzyme 2	Homo sapiens	129-133
33130382-4	2021	Further, binding efficiency of the most potent nisin H was evaluated through the interaction of hACE2:nisin H complex with RBD (receptor-binding domain) of SARS-CoV-2 and that of hACE2:RBD complex with nisin H. Here, nisin H acted as a potential competitor of RBD to access the hACE2 receptor.	nisin h	47-54	angiotensin converting enzyme 2	Homo sapiens	179-184
33072499-6	2021	Results show that rhein, forsythoside A, forsythoside I, neochlorogenic acid and its isomers exhibited high inhibitory effect on ACE2.	5'-O-caffeoylquinic acid	57-76	angiotensin converting enzyme 2	Homo sapiens	129-133
33130382-4	2021	Further, binding efficiency of the most potent nisin H was evaluated through the interaction of hACE2:nisin H complex with RBD (receptor-binding domain) of SARS-CoV-2 and that of hACE2:RBD complex with nisin H. Here, nisin H acted as a potential competitor of RBD to access the hACE2 receptor.	nisin h	47-54	angiotensin converting enzyme 2	Homo sapiens	179-184
33130382-4	2021	Further, binding efficiency of the most potent nisin H was evaluated through the interaction of hACE2:nisin H complex with RBD (receptor-binding domain) of SARS-CoV-2 and that of hACE2:RBD complex with nisin H. Here, nisin H acted as a potential competitor of RBD to access the hACE2 receptor.	nisin h	102-109	angiotensin converting enzyme 2	Homo sapiens	96-101
33262453-0	2021	Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models.	dalbavancin	0-11	angiotensin converting enzyme 2	Homo sapiens	18-22
32991819-2	2021	Human agniotensin-converting enzyme 2 (hACE2) serves as an entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to infect people via binding to envelope spike proteins.	agniotensin	6-17	angiotensin converting enzyme 2	Homo sapiens	39-44
33727782-6	2021	The binding affinity of beta-bisabolene on the ACE2 target (- 8.0 kcal/mol) was almost the same as Remdesivir (- 8.1 kcal/mol).	beta-bisabolene	24-39	angiotensin converting enzyme 2	Homo sapiens	47-51
33517235-6	2021	RESULTS: There is minimal expression of ACE2 in the luminal classes, but significantly higher levels in the Basal-like and HER2-enriched subclasses.	Phenobarbital	52-59	angiotensin converting enzyme 2	Homo sapiens	40-44
33039392-2	2021	Motivated by a recent report showing estradiol-mediated downregulation of ACE2 in the airway epithelium,3 we hypothesized that the hormonal changes of pregnancy will decrease the expression of SARS-CoV-2 cell entry factors.	Estradiol	37-46	angiotensin converting enzyme 2	Homo sapiens	74-78
33121927-5	2021	Furthermore, baicalein significantly inhibited the body weight loss, the replication of the virus, and relieved the lesions of lung tissue in hACE2 transgenic mice infected with SARS-CoV-2.	baicalein	13-22	angiotensin converting enzyme 2	Homo sapiens	142-147
33272568-10	2021	Reorientation of several crucial residues at the RBD-ACE2 interface facilitates additional hydrogen bond formation for the V367F variant which enhances the binding energy during ACE2 recognition.	Hydrogen	91-99	angiotensin converting enzyme 2	Homo sapiens	53-57
33272568-10	2021	Reorientation of several crucial residues at the RBD-ACE2 interface facilitates additional hydrogen bond formation for the V367F variant which enhances the binding energy during ACE2 recognition.	Hydrogen	91-99	angiotensin converting enzyme 2	Homo sapiens	178-182
33442693-9	2021	Weight loss and lethality following intranasal infection of transgenic hACE2 mice with CoV-2 was prevented by one or two immunizations with rMVAs or by passive transfer of serum from vaccinated mice.	rmvas	140-145	angiotensin converting enzyme 2	Homo sapiens	71-76
32990980-2	2021	Vitamin D (VitD) can upregulate ACE2 and has an antagonistic effect on Renin, which exerts a vasodilatation and anti-inflammatory effect against coronavirus disease (COVID-19).	Vitamin D	0-9	angiotensin converting enzyme 2	Homo sapiens	32-36
33262453-4	2021	Our results showed that dalbavancin directly binds to human angiotensin-converting enzyme 2 (ACE2) with high affinity, thereby blocking its interaction with the SARS-CoV-2 spike protein.	dalbavancin	24-35	angiotensin converting enzyme 2	Homo sapiens	60-91
33262453-4	2021	Our results showed that dalbavancin directly binds to human angiotensin-converting enzyme 2 (ACE2) with high affinity, thereby blocking its interaction with the SARS-CoV-2 spike protein.	dalbavancin	24-35	angiotensin converting enzyme 2	Homo sapiens	93-97
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	Quercetin	75-84	angiotensin converting enzyme 2	Homo sapiens	197-202
32972339-6	2021	The priming of the spike (S) protein of the virus by proteolytic cleavage by the trans-membrane serine protease-2 (TMPRSS2) is necessary for fusion of the virus to the host cell after it binds to its receptor angiotensin converting enzyme-2 (ACE2).	Serine	96-102	angiotensin converting enzyme 2	Homo sapiens	209-240
32972339-6	2021	The priming of the spike (S) protein of the virus by proteolytic cleavage by the trans-membrane serine protease-2 (TMPRSS2) is necessary for fusion of the virus to the host cell after it binds to its receptor angiotensin converting enzyme-2 (ACE2).	Serine	96-102	angiotensin converting enzyme 2	Homo sapiens	242-246
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	Quercetin	75-84	angiotensin converting enzyme 2	Homo sapiens	249-254
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	Gallic Acid	146-157	angiotensin converting enzyme 2	Homo sapiens	197-202
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	Gallic Acid	146-157	angiotensin converting enzyme 2	Homo sapiens	249-254
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	Curcumin	86-94	angiotensin converting enzyme 2	Homo sapiens	197-202
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	esculetin	228-237	angiotensin converting enzyme 2	Homo sapiens	197-202
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	esculetin	228-237	angiotensin converting enzyme 2	Homo sapiens	249-254
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	Curcumin	86-94	angiotensin converting enzyme 2	Homo sapiens	249-254
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	naringenin	96-106	angiotensin converting enzyme 2	Homo sapiens	197-202
33459225-8	2021	Regarding terpenoids and alkaloids, nimbin, withaferin A, andrographolide, zingiberene and, berberine, piperine and thebaine, respectively, showed binding affinity with molecular ACE-2 target in silico.	Terpenes	10-20	angiotensin converting enzyme 2	Homo sapiens	179-184
33459225-8	2021	Regarding terpenoids and alkaloids, nimbin, withaferin A, andrographolide, zingiberene and, berberine, piperine and thebaine, respectively, showed binding affinity with molecular ACE-2 target in silico.	Alkaloids	25-34	angiotensin converting enzyme 2	Homo sapiens	179-184
33459225-8	2021	Regarding terpenoids and alkaloids, nimbin, withaferin A, andrographolide, zingiberene and, berberine, piperine and thebaine, respectively, showed binding affinity with molecular ACE-2 target in silico.	nimbin	36-42	angiotensin converting enzyme 2	Homo sapiens	179-184
33459225-8	2021	Regarding terpenoids and alkaloids, nimbin, withaferin A, andrographolide, zingiberene and, berberine, piperine and thebaine, respectively, showed binding affinity with molecular ACE-2 target in silico.	withaferin A	44-56	angiotensin converting enzyme 2	Homo sapiens	179-184
33459225-8	2021	Regarding terpenoids and alkaloids, nimbin, withaferin A, andrographolide, zingiberene and, berberine, piperine and thebaine, respectively, showed binding affinity with molecular ACE-2 target in silico.	andrographolide	58-73	angiotensin converting enzyme 2	Homo sapiens	179-184
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	naringenin	96-106	angiotensin converting enzyme 2	Homo sapiens	249-254
33459225-8	2021	Regarding terpenoids and alkaloids, nimbin, withaferin A, andrographolide, zingiberene and, berberine, piperine and thebaine, respectively, showed binding affinity with molecular ACE-2 target in silico.	zingiberene	75-86	angiotensin converting enzyme 2	Homo sapiens	179-184
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	Luteolin	108-116	angiotensin converting enzyme 2	Homo sapiens	197-202
33459225-8	2021	Regarding terpenoids and alkaloids, nimbin, withaferin A, andrographolide, zingiberene and, berberine, piperine and thebaine, respectively, showed binding affinity with molecular ACE-2 target in silico.	Berberine	92-101	angiotensin converting enzyme 2	Homo sapiens	179-184
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	Luteolin	108-116	angiotensin converting enzyme 2	Homo sapiens	249-254
33459225-8	2021	Regarding terpenoids and alkaloids, nimbin, withaferin A, andrographolide, zingiberene and, berberine, piperine and thebaine, respectively, showed binding affinity with molecular ACE-2 target in silico.	piperine	103-111	angiotensin converting enzyme 2	Homo sapiens	179-184
33459225-8	2021	Regarding terpenoids and alkaloids, nimbin, withaferin A, andrographolide, zingiberene and, berberine, piperine and thebaine, respectively, showed binding affinity with molecular ACE-2 target in silico.	Thebaine	116-124	angiotensin converting enzyme 2	Homo sapiens	179-184
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	Hesperidin	118-128	angiotensin converting enzyme 2	Homo sapiens	197-202
33459225-10	2021	It is important to mention that some natural compounds such as magnolol, resveratrol, rosmarinic acid, tanshinone IIA, and nicotine have also demonstrated the potential to increase the activity or expression of ACE-2, and could therefore aggravate SARS-CoV-2 infection.	magnolol	63-71	angiotensin converting enzyme 2	Homo sapiens	211-216
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	Hesperidin	118-128	angiotensin converting enzyme 2	Homo sapiens	249-254
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	mangiferin	130-140	angiotensin converting enzyme 2	Homo sapiens	197-202
33459225-10	2021	It is important to mention that some natural compounds such as magnolol, resveratrol, rosmarinic acid, tanshinone IIA, and nicotine have also demonstrated the potential to increase the activity or expression of ACE-2, and could therefore aggravate SARS-CoV-2 infection.	Resveratrol	73-84	angiotensin converting enzyme 2	Homo sapiens	211-216
33459225-10	2021	It is important to mention that some natural compounds such as magnolol, resveratrol, rosmarinic acid, tanshinone IIA, and nicotine have also demonstrated the potential to increase the activity or expression of ACE-2, and could therefore aggravate SARS-CoV-2 infection.	rosmarinic acid	86-101	angiotensin converting enzyme 2	Homo sapiens	211-216
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	mangiferin	130-140	angiotensin converting enzyme 2	Homo sapiens	249-254
33459225-10	2021	It is important to mention that some natural compounds such as magnolol, resveratrol, rosmarinic acid, tanshinone IIA, and nicotine have also demonstrated the potential to increase the activity or expression of ACE-2, and could therefore aggravate SARS-CoV-2 infection.	tanshinone	103-117	angiotensin converting enzyme 2	Homo sapiens	211-216
33130103-2	2021	Recently, ACE2 was identified as a primary receptor for SARS coronaviruses, SARS-CoV and SARS-CoV-2, being expressed in multiple tissues including the luminal surface of the gut.	Phenobarbital	151-158	angiotensin converting enzyme 2	Homo sapiens	10-14
33459225-10	2021	It is important to mention that some natural compounds such as magnolol, resveratrol, rosmarinic acid, tanshinone IIA, and nicotine have also demonstrated the potential to increase the activity or expression of ACE-2, and could therefore aggravate SARS-CoV-2 infection.	Nicotine	123-131	angiotensin converting enzyme 2	Homo sapiens	211-216
33550966-2	2021	The present work is an effort for a computational target to block the spike proteins (S) and ACE2 receptor proteins with Macrolide antibiotics like Azithromycin, (AZM), Clarithromycin (CLAM) and Erythromycin (ERY) along with RNA-dependent RNA polymerase (RdRp).	Macrolides	121-130	angiotensin converting enzyme 2	Homo sapiens	93-97
33550966-2	2021	The present work is an effort for a computational target to block the spike proteins (S) and ACE2 receptor proteins with Macrolide antibiotics like Azithromycin, (AZM), Clarithromycin (CLAM) and Erythromycin (ERY) along with RNA-dependent RNA polymerase (RdRp).	Azithromycin	148-160	angiotensin converting enzyme 2	Homo sapiens	93-97
33550966-2	2021	The present work is an effort for a computational target to block the spike proteins (S) and ACE2 receptor proteins with Macrolide antibiotics like Azithromycin, (AZM), Clarithromycin (CLAM) and Erythromycin (ERY) along with RNA-dependent RNA polymerase (RdRp).	Azithromycin	163-166	angiotensin converting enzyme 2	Homo sapiens	93-97
33550966-2	2021	The present work is an effort for a computational target to block the spike proteins (S) and ACE2 receptor proteins with Macrolide antibiotics like Azithromycin, (AZM), Clarithromycin (CLAM) and Erythromycin (ERY) along with RNA-dependent RNA polymerase (RdRp).	Clarithromycin	169-183	angiotensin converting enzyme 2	Homo sapiens	93-97
33550966-2	2021	The present work is an effort for a computational target to block the spike proteins (S) and ACE2 receptor proteins with Macrolide antibiotics like Azithromycin, (AZM), Clarithromycin (CLAM) and Erythromycin (ERY) along with RNA-dependent RNA polymerase (RdRp).	Clarithromycin	185-189	angiotensin converting enzyme 2	Homo sapiens	93-97
33550966-2	2021	The present work is an effort for a computational target to block the spike proteins (S) and ACE2 receptor proteins with Macrolide antibiotics like Azithromycin, (AZM), Clarithromycin (CLAM) and Erythromycin (ERY) along with RNA-dependent RNA polymerase (RdRp).	Erythromycin	195-207	angiotensin converting enzyme 2	Homo sapiens	93-97
33550966-2	2021	The present work is an effort for a computational target to block the spike proteins (S) and ACE2 receptor proteins with Macrolide antibiotics like Azithromycin, (AZM), Clarithromycin (CLAM) and Erythromycin (ERY) along with RNA-dependent RNA polymerase (RdRp).	Erythromycin	209-212	angiotensin converting enzyme 2	Homo sapiens	93-97
33550966-6	2021	Interaction of CLAM and ERY presented low binding energy (-6.8 and -6.6) with the ACE2 receptor.	Clarithromycin	15-19	angiotensin converting enzyme 2	Homo sapiens	82-86
33550966-6	2021	Interaction of CLAM and ERY presented low binding energy (-6.8 and -6.6) with the ACE2 receptor.	Erythromycin	24-27	angiotensin converting enzyme 2	Homo sapiens	82-86
33550966-8	2021	Macrolides not only affected the attachment to ACE2 but also blocked the spike proteins further, consequently inhibiting the internalization in the host cell.	Macrolides	0-10	angiotensin converting enzyme 2	Homo sapiens	47-51
33550966-12	2021	The present study gives three-way options either by blocking S proteins or ACE2 receptor proteins or inhibiting RdRp to counter any effect of COVID-19 by macrolide and could be useful in the treatment of COVID-19 till some better option available.	Macrolides	154-163	angiotensin converting enzyme 2	Homo sapiens	75-79
33301987-7	2021	The interaction interfaces of SARS-CoV-2S RBD and ACE2 protein complex suggests pangolin as a potential intermediate host in SARS-CoV-2.	pangolin	80-88	angiotensin converting enzyme 2	Homo sapiens	50-54
32522617-2	2021	Like SARS-CoV, angiotencin converting enzyme (ACE)2 as a functional receptor for SARS-CoV2 is essential for the virus to make an entry into the cell.	angiotencin	15-26	angiotensin converting enzyme 2	Homo sapiens	46-51
32522617-3	2021	ACE2 is a part of Renin-Angiotensin-Aldosterone System, which is expressed in several organs that opposes the angiotensin (Ang) II functions by converting Ang II to Ang (1-7), the one with vasodilation effects.	Aldosterone	36-47	angiotensin converting enzyme 2	Homo sapiens	0-4
33649734-6	2021	This study selected these drugs for MD simulation investigation whose results demonstrated that ledipasvir with ACE2, estradiol benzoate with CD147, and vancomycin with RDRP represented the most favorable DeltaG.	ledipasvir	96-106	angiotensin converting enzyme 2	Homo sapiens	112-116
33129966-7	2021	Vitamin D was found to affect ACE2, the target of SARS-CoV-2; therefore, we propose that vitamin D might alleviate ARDS and acute lung injury induced by SARS-CoV-2 by modulating ACE2.	Vitamin D	0-9	angiotensin converting enzyme 2	Homo sapiens	30-34
33649734-7	2021	Also, paritaprevir and vancomycin have good binding energy with both targets (ACE2 and RdRp).	paritaprevir	6-18	angiotensin converting enzyme 2	Homo sapiens	78-82
33649734-7	2021	Also, paritaprevir and vancomycin have good binding energy with both targets (ACE2 and RdRp).	Vancomycin	23-33	angiotensin converting enzyme 2	Homo sapiens	78-82
33166692-7	2021	Results confirm a strong binding affinity of LPD-12 with ACE2 with a binding free energy of -1621.62 kcal which can also prevent the binding of S-protein, reciprocally.	lpd-12	45-51	angiotensin converting enzyme 2	Homo sapiens	57-61
33166692-8	2021	Thus it can be concluded that LPD-12 may act as a potential therapeutic drug by reducing the entry of SARS-CoV-2 to the human cells via ACE2 receptor and related infections.	lpd-12	30-36	angiotensin converting enzyme 2	Homo sapiens	136-140
33129966-7	2021	Vitamin D was found to affect ACE2, the target of SARS-CoV-2; therefore, we propose that vitamin D might alleviate ARDS and acute lung injury induced by SARS-CoV-2 by modulating ACE2.	Vitamin D	0-9	angiotensin converting enzyme 2	Homo sapiens	178-182
33129966-7	2021	Vitamin D was found to affect ACE2, the target of SARS-CoV-2; therefore, we propose that vitamin D might alleviate ARDS and acute lung injury induced by SARS-CoV-2 by modulating ACE2.	Vitamin D	89-98	angiotensin converting enzyme 2	Homo sapiens	30-34
33129966-7	2021	Vitamin D was found to affect ACE2, the target of SARS-CoV-2; therefore, we propose that vitamin D might alleviate ARDS and acute lung injury induced by SARS-CoV-2 by modulating ACE2.	Vitamin D	89-98	angiotensin converting enzyme 2	Homo sapiens	178-182
32719447-7	2021	Moreover, SARS-CoV-2 tropism and interaction with the RAAS system, through ACE2 receptor, possibly enhances inflammation response and cardiac aggression, leading to imperative concerns about the use of ACEi and ARBs in infected patients.	acei	202-206	angiotensin converting enzyme 2	Homo sapiens	75-79
33188364-4	2021	Angiotensin-converting enzyme 2 (ACE2), which is part of the renin-angiotensin-aldosterone system (RAAS), is the main entry receptor for SARS-CoV-2; although dipeptidyl peptidase 4 (DPP4) might also act as a binding target.	Aldosterone	79-90	angiotensin converting enzyme 2	Homo sapiens	0-31
32613681-9	2021	Experimentally, vitamin D increases the ratio of angiotensin-converting enzyme 2 (ACE2) to ACE, thus increasing angiotensin II hydrolysis and reducing subsequent inflammatory cytokine response to pathogens and lung injury.	Vitamin D	16-25	angiotensin converting enzyme 2	Homo sapiens	49-80
32613681-9	2021	Experimentally, vitamin D increases the ratio of angiotensin-converting enzyme 2 (ACE2) to ACE, thus increasing angiotensin II hydrolysis and reducing subsequent inflammatory cytokine response to pathogens and lung injury.	Vitamin D	16-25	angiotensin converting enzyme 2	Homo sapiens	82-86
33626315-8	2021	The intestinal ACE2 receptor is associated with the neutral amino acid transporter B0AT1 and ACE2 is necessary for the expression of this transporter on the luminal surface of intestinal epithelial cells.	Phenobarbital	157-164	angiotensin converting enzyme 2	Homo sapiens	15-19
33626315-8	2021	The intestinal ACE2 receptor is associated with the neutral amino acid transporter B0AT1 and ACE2 is necessary for the expression of this transporter on the luminal surface of intestinal epithelial cells.	Phenobarbital	157-164	angiotensin converting enzyme 2	Homo sapiens	93-97
32613681-0	2021	Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis.	Vitamin D	13-22	angiotensin converting enzyme 2	Homo sapiens	121-125
33135833-2	2021	HYPOTHESIS/OBJECTIVES: Angiotensin receptor blockers (ARBs) would alter balance of APs and differences would be magnified in vitro by incubation of plasma samples with recombinant human ACE2 (rhACE2).	rhace2	192-198	angiotensin converting enzyme 2	Homo sapiens	186-190
33189453-5	2021	Here, I will rationalize the possibility that other host molecules-i.e., sugar molecules and the sialic acidsN-glycolylneuraminic acid, N-acetylneuraminic acid, and their derivates could be viable candidates for the use as virus receptors by SARS-CoV-2 and/or serve as determinants for the adherence on ACE2 of SARS-CoV-2.	Sugars	73-78	angiotensin converting enzyme 2	Homo sapiens	303-307
33189453-5	2021	Here, I will rationalize the possibility that other host molecules-i.e., sugar molecules and the sialic acidsN-glycolylneuraminic acid, N-acetylneuraminic acid, and their derivates could be viable candidates for the use as virus receptors by SARS-CoV-2 and/or serve as determinants for the adherence on ACE2 of SARS-CoV-2.	sialic acidsn-glycolylneuraminic acid	97-134	angiotensin converting enzyme 2	Homo sapiens	303-307
33188364-4	2021	Angiotensin-converting enzyme 2 (ACE2), which is part of the renin-angiotensin-aldosterone system (RAAS), is the main entry receptor for SARS-CoV-2; although dipeptidyl peptidase 4 (DPP4) might also act as a binding target.	Aldosterone	79-90	angiotensin converting enzyme 2	Homo sapiens	33-37
33406522-8	2021	A single amino acid aspartate-454, that causes dissociation of the RBD of the spike and ACE2, and F486 which gives the strength of binding with ACE2 remain intact in all coronaviruses.	Aspartic Acid	20-29	angiotensin converting enzyme 2	Homo sapiens	88-92
33387941-3	2021	Angiotensin-converting enzyme 2 (ACE2), an important component of the renin-angiotensin-aldosterone system (RAAS), displays circadian rhythmicity.	Aldosterone	88-99	angiotensin converting enzyme 2	Homo sapiens	0-31
33387941-3	2021	Angiotensin-converting enzyme 2 (ACE2), an important component of the renin-angiotensin-aldosterone system (RAAS), displays circadian rhythmicity.	Aldosterone	88-99	angiotensin converting enzyme 2	Homo sapiens	33-37
32651900-6	2021	In addition, the endogenous androgen milieu and its receptors are associated with ACE2 activation reflecting that enhanced testosterone levels may trigger the pathogenesis of COVID-19.	Testosterone	123-135	angiotensin converting enzyme 2	Homo sapiens	82-86
33406522-8	2021	A single amino acid aspartate-454, that causes dissociation of the RBD of the spike and ACE2, and F486 which gives the strength of binding with ACE2 remain intact in all coronaviruses.	Aspartic Acid	20-29	angiotensin converting enzyme 2	Homo sapiens	144-148
33520633-0	2021	In-silico drug repurposing study: Amprenavir, enalaprilat, and plerixafor, potential drugs for destabilizing the SARS-CoV-2 S-protein-angiotensin-converting enzyme 2 complex.	amprenavir	34-44	angiotensin converting enzyme 2	Homo sapiens	134-165
33520633-0	2021	In-silico drug repurposing study: Amprenavir, enalaprilat, and plerixafor, potential drugs for destabilizing the SARS-CoV-2 S-protein-angiotensin-converting enzyme 2 complex.	Enalaprilat	46-57	angiotensin converting enzyme 2	Homo sapiens	134-165
33520633-9	2021	Plerixafor is the drug with the greatest potential to destabilize the SP-ACE2 complex, followed by amprenavir and enalaprilat; thus, these three drugs are proposed for future in vitro and in vivo evaluations.	plerixafor	0-10	angiotensin converting enzyme 2	Homo sapiens	73-77
33520633-0	2021	In-silico drug repurposing study: Amprenavir, enalaprilat, and plerixafor, potential drugs for destabilizing the SARS-CoV-2 S-protein-angiotensin-converting enzyme 2 complex.	plerixafor	63-73	angiotensin converting enzyme 2	Homo sapiens	134-165
33520633-7	2021	Using umbrella sampling molecular dynamics simulations, the binding energy of SP with ACE2 (-29.58 kcal/mol) without ligands, and in complex with amprenavir (-20.13 kcal/mol), enalaprilat (-23.84 kcal/mol), and plerixafor (-19.72 kcal/mol) were calculated.	Enalaprilat	176-187	angiotensin converting enzyme 2	Homo sapiens	86-90
33520633-7	2021	Using umbrella sampling molecular dynamics simulations, the binding energy of SP with ACE2 (-29.58 kcal/mol) without ligands, and in complex with amprenavir (-20.13 kcal/mol), enalaprilat (-23.84 kcal/mol), and plerixafor (-19.72 kcal/mol) were calculated.	plerixafor	211-221	angiotensin converting enzyme 2	Homo sapiens	86-90
33379366-1	2020	(1) Background: Nicotine is implicated in the SARS-COV-2 infection through activation of the alpha7-nAChR and over-expression of ACE2.	Nicotine	16-24	angiotensin converting enzyme 2	Homo sapiens	129-133
33382930-7	2021	Insight is provided into the effect of vitamin A on ACE-2 expression in the respiratory tract and its association with the prognosis of Covid-19 patients.	Vitamin A	39-48	angiotensin converting enzyme 2	Homo sapiens	52-57
33326798-4	2020	The disulfide-bonded ACE2 microbody protein inhibits entry of SARS-CoV-2 spike protein pseudotyped virus and replication of live SARS-CoV-2 in vitro and in a mouse model.	Disulfides	4-13	angiotensin converting enzyme 2	Homo sapiens	21-25
33381197-19	2020	Conclusions: Atractylenolide III is predicted to have a strong binding affinity with ACE2 and eligible pharmacokinetic properties, anti-inflammatory effects and antiviral effects in in vitro study, and high distribution on the lungs in in vivo study.	atractylenolide III	13-32	angiotensin converting enzyme 2	Homo sapiens	85-89
33374387-0	2020	Blocking Effect of Demethylzeylasteral on the Interaction between Human ACE2 Protein and SARS-CoV-2 RBD Protein Discovered Using SPR Technology.	demethylzeylasteral	19-38	angiotensin converting enzyme 2	Homo sapiens	72-76
33295347-4	2020	The results showed that the RBD of 2019-nCov bound much stronger with ACE2 than that of SARS-CoV due to a better organized hydrogen bond network between the former pair with most of the residues at the contact interface sharing the responsibility to hold the pair tightly.	Hydrogen	123-131	angiotensin converting enzyme 2	Homo sapiens	70-74
33353972-4	2020	The lead nanobody candidate, NIH-CoVnb-112, blocks SARS-CoV-2 spike pseudotyped lentivirus infection of HEK293 cells expressing human ACE2 with an EC50 of 0.3 microg/mL.	nih-covnb-112	29-42	angiotensin converting enzyme 2	Homo sapiens	134-138
33353972-6	2020	Furthermore, NIH-CoVnb-112 blocks interaction between ACE2 and several high affinity variant forms of the spike protein.	nih-covnb-112	13-26	angiotensin converting enzyme 2	Homo sapiens	54-58
33331243-4	2020	The binding of COVA2-04 antibody to SARS-CoV-2 RBD is more energetically favorable than the binding of COVA2-39, but also less favorable than the formation of SARS-CoV-2 RBD-ACE2 complex.	cova2	15-20	angiotensin converting enzyme 2	Homo sapiens	174-178
33342421-0	2021	Possible therapeutic interventions in COVID-19 induced ARDS by cotinine as an ACE-2 promoter and AT-1R blocker.	Cotinine	63-71	angiotensin converting enzyme 2	Homo sapiens	78-83
33469570-7	2020	In this study, Molecular docking is employed to analyze the binding of two chemical compounds, SSAA09E2 and Nilotinib, with the druggable pocket of the ACE2-RBD complex.	N-((4-(4-methylpiperazin-1-yl)phenyl)methyl)-1,2-oxazole-5-carboxamide	95-103	angiotensin converting enzyme 2	Homo sapiens	152-156
33390952-9	2020	In addition, theaflavin-3-gallate could inhibit protein expression of ACE2 and TMPRSS2 without significant cytotoxicity.	Theaflavin 3-gallate	13-33	angiotensin converting enzyme 2	Homo sapiens	70-74
33390952-10	2020	Our results suggest that GB-1 and theaflavin-3-gallate could act as potential candidates for prophylaxis or treatment of SARS-CoV-2 infection through inhibiting protein expression of ACE2 and TMPRSS2 for the further study.	Theaflavin 3-gallate	34-54	angiotensin converting enzyme 2	Homo sapiens	183-187
33469570-7	2020	In this study, Molecular docking is employed to analyze the binding of two chemical compounds, SSAA09E2 and Nilotinib, with the druggable pocket of the ACE2-RBD complex.	nilotinib	108-117	angiotensin converting enzyme 2	Homo sapiens	152-156
33469570-9	2020	Results show that both Nilotinib and SSAA09E2 can induce significant conformational changes in the ACE2-RBD complex, intervene with the hydrogen bonds, and influence the flexibility of proteins.	nilotinib	23-32	angiotensin converting enzyme 2	Homo sapiens	99-103
33469570-9	2020	Results show that both Nilotinib and SSAA09E2 can induce significant conformational changes in the ACE2-RBD complex, intervene with the hydrogen bonds, and influence the flexibility of proteins.	N-((4-(4-methylpiperazin-1-yl)phenyl)methyl)-1,2-oxazole-5-carboxamide	37-45	angiotensin converting enzyme 2	Homo sapiens	99-103
33537555-4	2021	The renin-angiotensin-aldosterone system (RAAS) is strictly involved in COVID-19 because angiotensin converting enzyme 2 (ACE2) is the host receptor for SARS-CoV-2 and also converts pro-inflammatory angiotensin (Ang) II into anti-inflammatory Ang(1-7).	Aldosterone	22-33	angiotensin converting enzyme 2	Homo sapiens	89-120
33339432-6	2020	Using resonance energy transfer and cAMP and mitogen-activated protein kinase signaling assays, we found that human ACE2 interacts with RAS-related receptors, namely the angiotensin II type 1 receptor (AT1R), the angiotensin II type 2 receptor (AT2R), and the MAS1 oncogene receptor (MasR).	Cyclic AMP	36-40	angiotensin converting enzyme 2	Homo sapiens	116-120
33041407-4	2020	In this paper, computational approaches were employed, especially the structure-based virtual screening followed by molecular dynamics (MD) simulation as well as binding energy analysis for the computational identification of specific terpenes from the medicinal plants, which can block SARS-CoV-2 S-RBD binding to Human angiotensin-converting enzyme 2 (H-ACE2) and can act as potent anti-COVID-19 drugs after further advancements.	Terpenes	235-243	angiotensin converting enzyme 2	Homo sapiens	321-352
33041407-4	2020	In this paper, computational approaches were employed, especially the structure-based virtual screening followed by molecular dynamics (MD) simulation as well as binding energy analysis for the computational identification of specific terpenes from the medicinal plants, which can block SARS-CoV-2 S-RBD binding to Human angiotensin-converting enzyme 2 (H-ACE2) and can act as potent anti-COVID-19 drugs after further advancements.	Terpenes	235-243	angiotensin converting enzyme 2	Homo sapiens	356-360
33327522-2	2020	We recently found that inorganic polyphosphate (polyP), a physiological, metabolic energy (ATP)-providing polymer released from blood platelets, blocks the binding of the receptor binding domain (RBD) to the cellular ACE2 receptor in vitro.	inorganic polyphosphate	23-46	angiotensin converting enzyme 2	Homo sapiens	217-221
33327522-2	2020	We recently found that inorganic polyphosphate (polyP), a physiological, metabolic energy (ATP)-providing polymer released from blood platelets, blocks the binding of the receptor binding domain (RBD) to the cellular ACE2 receptor in vitro.	Polyphosphates	48-53	angiotensin converting enzyme 2	Homo sapiens	217-221
33381049-0	2020	A New Crystal Form of the SARS-CoV-2 Receptor Binding Domain: CR3022 Complex-An Ideal Target for In-Crystal Fragment Screening of the ACE2 Binding Site Surface.	cr3022	62-68	angiotensin converting enzyme 2	Homo sapiens	134-138
33537555-4	2021	The renin-angiotensin-aldosterone system (RAAS) is strictly involved in COVID-19 because angiotensin converting enzyme 2 (ACE2) is the host receptor for SARS-CoV-2 and also converts pro-inflammatory angiotensin (Ang) II into anti-inflammatory Ang(1-7).	Aldosterone	22-33	angiotensin converting enzyme 2	Homo sapiens	122-126
33330862-5	2020	Elevated ACE2 expression and viral entry were mediated by increased JAK-STAT signalling, and were reversed by the JAK inhibitor, tofacitinib.	tofacitinib	129-140	angiotensin converting enzyme 2	Homo sapiens	9-13
33363465-8	2020	Notably, our results identified ACE/ACE2-ATR1-Cholesterol-HDAC axis signals that also matched with some available clinical data.	Cholesterol	46-57	angiotensin converting enzyme 2	Homo sapiens	36-40
33330868-0	2021	Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies.	Sulfhydryl Compounds	59-64	angiotensin converting enzyme 2	Homo sapiens	39-43
33293627-0	2020	SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress.	Serine	77-83	angiotensin converting enzyme 2	Homo sapiens	20-24
33231598-0	2020	The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor.	Polyphosphates	16-29	angiotensin converting enzyme 2	Homo sapiens	104-108
33293627-5	2020	We aimed at identifying genes co-expressed with angiotensin I converting enzyme 2 (ACE2) the human cell entry receptor of SARS-CoV-2, and unveiled several genes correlated or inversely correlated with high significance, among the most significant of these was the transmembrane serine protease 4 (TMPRSS4).	Serine	278-284	angiotensin converting enzyme 2	Homo sapiens	48-81
33231598-1	2020	The effect of the polyanionic polymer of inorganic polyphosphate (polyP) involved in innate immunity on the binding of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to the cellular ACE2 receptor was studied.	polyanionic polymer	18-37	angiotensin converting enzyme 2	Homo sapiens	201-205
33293627-5	2020	We aimed at identifying genes co-expressed with angiotensin I converting enzyme 2 (ACE2) the human cell entry receptor of SARS-CoV-2, and unveiled several genes correlated or inversely correlated with high significance, among the most significant of these was the transmembrane serine protease 4 (TMPRSS4).	Serine	278-284	angiotensin converting enzyme 2	Homo sapiens	83-87
33278189-3	2020	While both ACE inhibitors and spironolactone can upregulate tissue ACE2, there are important points of discrimination between these approaches.	Spironolactone	30-44	angiotensin converting enzyme 2	Homo sapiens	67-71
33231598-1	2020	The effect of the polyanionic polymer of inorganic polyphosphate (polyP) involved in innate immunity on the binding of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to the cellular ACE2 receptor was studied.	Polyphosphates	51-64	angiotensin converting enzyme 2	Homo sapiens	201-205
33231598-1	2020	The effect of the polyanionic polymer of inorganic polyphosphate (polyP) involved in innate immunity on the binding of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to the cellular ACE2 receptor was studied.	Polyphosphates	66-71	angiotensin converting enzyme 2	Homo sapiens	201-205
33278189-4	2020	The virus requires proteolytic processing of its spike protein by transmembrane protease receptor serine type 2 (TMPRSS2) to enable binding to cellular ACE2.	Serine	98-104	angiotensin converting enzyme 2	Homo sapiens	152-156
33294307-10	2021	Our in silico study revealed that losartan and imatinib could probably: (1) decline SARS-CoV2 affinity to ACE2.	Losartan	34-42	angiotensin converting enzyme 2	Homo sapiens	106-110
32808185-9	2020	Within the analgesics, acetaminophen revealed a dose-dependent reduction in expression of ACE2, while non-steroidal anti-inflammatory drugs had mixed effect on receptors expression.	Acetaminophen	23-36	angiotensin converting enzyme 2	Homo sapiens	90-94
33294307-10	2021	Our in silico study revealed that losartan and imatinib could probably: (1) decline SARS-CoV2 affinity to ACE2.	Imatinib Mesylate	47-55	angiotensin converting enzyme 2	Homo sapiens	106-110
32852610-11	2020	EPC-EXsACE2 augmented these effects, which were attenuated by ACE2 inhibitor (DX600).	dx600	78-83	angiotensin converting enzyme 2	Homo sapiens	7-11
32905794-0	2020	The inorganic polymer, polyphosphate, blocks binding of SARS-CoV-2 spike protein to ACE2 receptor at physiological concentrations.	Polymers	14-21	angiotensin converting enzyme 2	Homo sapiens	84-88
32905794-0	2020	The inorganic polymer, polyphosphate, blocks binding of SARS-CoV-2 spike protein to ACE2 receptor at physiological concentrations.	Polyphosphates	23-36	angiotensin converting enzyme 2	Homo sapiens	84-88
33049583-7	2020	In the compositions of GB-2, we discovered that 50 mug/mL of theaflavin could inhibit protein expression of ACE2 and TMPRSS2.	theaflavin	61-71	angiotensin converting enzyme 2	Homo sapiens	108-112
33049583-8	2020	Theaflavin could inhibit the mRNA expression of ACE2.	theaflavin	0-10	angiotensin converting enzyme 2	Homo sapiens	48-52
33049583-9	2020	In conclusion, our results suggest that GB-2 and theaflavin could act as potential compounds for ACE2 and TMPRSS2 inhibitors in the further clinical study.	theaflavin	49-59	angiotensin converting enzyme 2	Homo sapiens	97-101
32522067-7	2020	In this short perspective, we discuss the roles of CQ/HCQ in the treatment of COVID-19 patients and propose new ways of possible treatment for SARS-CoV-2 infection based on the molecules that selectivity target autophagy.Abbreviation: ACE2: angiotensin I converting enzyme 2; CoV: coronavirus; CQ: chloroquine; ER: endoplasmic reticulum; HCQ: hydroxychloroquine; MERS-CoV: Middle East respiratory syndrome coronavirus; SARS-CoV: severe acute respiratory syndrome coronavirus; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2.	Chloroquine	298-309	angiotensin converting enzyme 2	Homo sapiens	235-239
32522067-7	2020	In this short perspective, we discuss the roles of CQ/HCQ in the treatment of COVID-19 patients and propose new ways of possible treatment for SARS-CoV-2 infection based on the molecules that selectivity target autophagy.Abbreviation: ACE2: angiotensin I converting enzyme 2; CoV: coronavirus; CQ: chloroquine; ER: endoplasmic reticulum; HCQ: hydroxychloroquine; MERS-CoV: Middle East respiratory syndrome coronavirus; SARS-CoV: severe acute respiratory syndrome coronavirus; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2.	Hydroxychloroquine	338-341	angiotensin converting enzyme 2	Homo sapiens	235-239
32522067-7	2020	In this short perspective, we discuss the roles of CQ/HCQ in the treatment of COVID-19 patients and propose new ways of possible treatment for SARS-CoV-2 infection based on the molecules that selectivity target autophagy.Abbreviation: ACE2: angiotensin I converting enzyme 2; CoV: coronavirus; CQ: chloroquine; ER: endoplasmic reticulum; HCQ: hydroxychloroquine; MERS-CoV: Middle East respiratory syndrome coronavirus; SARS-CoV: severe acute respiratory syndrome coronavirus; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2.	Hydroxychloroquine	343-361	angiotensin converting enzyme 2	Homo sapiens	235-239
33299995-11	2020	Our results suggest that in addition to residues that are in direct contact with the interface those involved in long range allosteric communication are also a determinant of the stability of the RBD-ACE2 complex.	rbd	196-199	angiotensin converting enzyme 2	Homo sapiens	200-204
33024003-6	2020	Protein levels of ACE2 were visualized by immunohistochemistry on paraffin-embedded lung tissue samples and quantified in alveolar and bronchial epithelium.	Paraffin	66-74	angiotensin converting enzyme 2	Homo sapiens	18-22
32809116-8	2020	In this paper, we also review the pathogenesis of SARS-CoV-2 infection and how it worsens CVD and postulate that the differences in modulation of the renin-angiotensin-aldosterone system (RAAS) axis which controls angiotensin-converting enzyme (ACE)/ACE2 balance may be an important determinant of COVID-19 outcomes in Africa.	Aldosterone	168-179	angiotensin converting enzyme 2	Homo sapiens	250-254
33017071-3	2020	Previous animal studies have demonstrated an increased ACE2 expression following treatment with either ACE inhibitors or angiotensin 1-receptor blockers (ACEi/ARB) that have led to a massive precariousness regarding the optimal cardiovascular therapy during this pandemic.	acei	154-158	angiotensin converting enzyme 2	Homo sapiens	55-59
33017071-7	2020	Similarly, analysis of 18 ventricular biopsies revealed a significant and independent increase in ACE2 mRNA expression in patients with end-stage heart failure that were treated with ACEi/ARB.	acei	183-187	angiotensin converting enzyme 2	Homo sapiens	98-102
33017071-9	2020	CONCLUSION: Treatment with ACEi/ARB is independently associated with an increased myocardial ACE2 mRNA expression in patients with coronary artery heart disease and in patients with end-stage heart failure.	acei	27-31	angiotensin converting enzyme 2	Homo sapiens	93-97
33170317-7	2020	Indeed, although mostly neglected, ACE2 can also act on [des-Arg 937]-bradykinin of the kinin-kallikrein system regulating coagulation and inflammation.	des-arg 937]	57-69	angiotensin converting enzyme 2	Homo sapiens	35-39
32693122-0	2020	A molecular docking study revealed that synthetic peptides induced conformational changes in the structure of SARS-CoV-2 spike glycoprotein, disrupting the interaction with human ACE2 receptor.	Peptides	50-58	angiotensin converting enzyme 2	Homo sapiens	179-183
33033170-7	2020	Further, we have shown possible interactions between nicotine/smoking and ACE2 in the lungs and brain which could aggravate the transmission and pathobiology of COVID-19 resulting in a poor disease outcome.	Nicotine	53-61	angiotensin converting enzyme 2	Homo sapiens	74-78
33033170-9	2020	It focuses on the potential negative impact of tobacco and nicotine exposure on the outcomes of this disease by interaction with the ACE2 receptor.	Nicotine	59-67	angiotensin converting enzyme 2	Homo sapiens	133-137
32866780-15	2020	CONCLUSION: We identified 4 already approved drugs (riboflavin, fenoterol, cangrelor and vidarabine) as possible agents for repurposing as inhibitors of S1:ACE2 interaction.	Riboflavin	52-62	angiotensin converting enzyme 2	Homo sapiens	156-160
32866780-15	2020	CONCLUSION: We identified 4 already approved drugs (riboflavin, fenoterol, cangrelor and vidarabine) as possible agents for repurposing as inhibitors of S1:ACE2 interaction.	Fenoterol	64-73	angiotensin converting enzyme 2	Homo sapiens	156-160
32866780-15	2020	CONCLUSION: We identified 4 already approved drugs (riboflavin, fenoterol, cangrelor and vidarabine) as possible agents for repurposing as inhibitors of S1:ACE2 interaction.	cangrelor	75-84	angiotensin converting enzyme 2	Homo sapiens	156-160
32866780-15	2020	CONCLUSION: We identified 4 already approved drugs (riboflavin, fenoterol, cangrelor and vidarabine) as possible agents for repurposing as inhibitors of S1:ACE2 interaction.	Vidarabine	89-99	angiotensin converting enzyme 2	Homo sapiens	156-160
33843160-4	2020	Darunavir (DRV) is another protease inhibitor that blocks the binding of SARS-CoV-2 to human angiotensin-converting enzyme 2 (Omotuyi et al., 2020).	Darunavir	0-9	angiotensin converting enzyme 2	Homo sapiens	93-124
33843160-4	2020	Darunavir (DRV) is another protease inhibitor that blocks the binding of SARS-CoV-2 to human angiotensin-converting enzyme 2 (Omotuyi et al., 2020).	Darunavir	11-14	angiotensin converting enzyme 2	Homo sapiens	93-124
32920291-6	2020	We further analyzed the binding character of CQ and HCQ to ACE2 by molecular docking and surface plasmon resonance (SPR) assays, 2019-nCoV spike pseudotyped virus was also used to observe the viropexis effect of CQ and HCQ in ACE2h cells.	Hydroxychloroquine	52-55	angiotensin converting enzyme 2	Homo sapiens	59-63
33443121-3	2020	ACE2 is part of the counter-regulatory renin-angiotensin-aldosterone system and is also expressed in the lower respiratory tract along the alveolar epithelium.	Aldosterone	57-68	angiotensin converting enzyme 2	Homo sapiens	0-4
32920291-6	2020	We further analyzed the binding character of CQ and HCQ to ACE2 by molecular docking and surface plasmon resonance (SPR) assays, 2019-nCoV spike pseudotyped virus was also used to observe the viropexis effect of CQ and HCQ in ACE2h cells.	Chloroquine	53-55	angiotensin converting enzyme 2	Homo sapiens	59-63
32920291-0	2020	Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus.	Hydroxychloroquine	16-34	angiotensin converting enzyme 2	Homo sapiens	38-42
32920291-7	2020	RESULTS: Results showed that HCQ is slightly more toxic to ACE2h cells than CQ.	Hydroxychloroquine	29-32	angiotensin converting enzyme 2	Homo sapiens	59-63
32920291-4	2020	PURPOSE: The objective of this study is to investigate whether CQ and HCQ could be ACE2 blockers and used to inhibit 2019-nCoV virus infection.	Chloroquine	63-65	angiotensin converting enzyme 2	Homo sapiens	83-87
32920291-4	2020	PURPOSE: The objective of this study is to investigate whether CQ and HCQ could be ACE2 blockers and used to inhibit 2019-nCoV virus infection.	Hydroxychloroquine	70-73	angiotensin converting enzyme 2	Homo sapiens	83-87
32920291-7	2020	RESULTS: Results showed that HCQ is slightly more toxic to ACE2h cells than CQ.	Chloroquine	30-32	angiotensin converting enzyme 2	Homo sapiens	59-63
32920291-5	2020	METHODS: In our study, we used CCK-8 staining, flow cytometry and immunofluorescent staining to evaluate the toxicity and autophagy of CQ and HCQ, respectively, on ACE2 high-expressing HEK293T cells (ACE2h cells).	Chloroquine	135-137	angiotensin converting enzyme 2	Homo sapiens	164-168
32920291-8	2020	Both CQ and HCQ could bind to ACE2 with KD = (7.31 +- 0.62)e-7 M and (4.82 +- 0.87)e-7 M, respectively.	Chloroquine	5-7	angiotensin converting enzyme 2	Homo sapiens	30-34
32920291-5	2020	METHODS: In our study, we used CCK-8 staining, flow cytometry and immunofluorescent staining to evaluate the toxicity and autophagy of CQ and HCQ, respectively, on ACE2 high-expressing HEK293T cells (ACE2h cells).	Chloroquine	135-137	angiotensin converting enzyme 2	Homo sapiens	200-204
32920291-8	2020	Both CQ and HCQ could bind to ACE2 with KD = (7.31 +- 0.62)e-7 M and (4.82 +- 0.87)e-7 M, respectively.	Hydroxychloroquine	12-15	angiotensin converting enzyme 2	Homo sapiens	30-34
32920291-5	2020	METHODS: In our study, we used CCK-8 staining, flow cytometry and immunofluorescent staining to evaluate the toxicity and autophagy of CQ and HCQ, respectively, on ACE2 high-expressing HEK293T cells (ACE2h cells).	Hydroxychloroquine	142-145	angiotensin converting enzyme 2	Homo sapiens	164-168
32920291-6	2020	We further analyzed the binding character of CQ and HCQ to ACE2 by molecular docking and surface plasmon resonance (SPR) assays, 2019-nCoV spike pseudotyped virus was also used to observe the viropexis effect of CQ and HCQ in ACE2h cells.	Chloroquine	45-47	angiotensin converting enzyme 2	Homo sapiens	59-63
32920291-10	2020	CONCLUSIONS: CQ and HCQ both inhibit the entrance 2019-nCoV into cells by blocking the binding of the virus with ACE2.	Chloroquine	13-15	angiotensin converting enzyme 2	Homo sapiens	113-117
32920291-10	2020	CONCLUSIONS: CQ and HCQ both inhibit the entrance 2019-nCoV into cells by blocking the binding of the virus with ACE2.	Hydroxychloroquine	20-23	angiotensin converting enzyme 2	Homo sapiens	113-117
33328008-2	2020	Angiotensin-converting enzyme 2 (ACE2), one of the binding sites for SARS-CoV-2 infection in humans, can bind to viral spike proteins, allowing transmembrane serine protease (TMPRSS2) to activate S-protein to trigger infection and induce the production of various inflammatory factors such as interleukin-1, interferon-l, and tumor necrosis factor.	Serine	158-164	angiotensin converting enzyme 2	Homo sapiens	0-31
33368089-8	2020	It is likely that inhibition of viral infection arises from an overlap between the binding sites of heparin/HS on S1 RBD and that of the angiotensin-converting enzyme 2.	Heparin	100-107	angiotensin converting enzyme 2	Homo sapiens	137-168
33328008-2	2020	Angiotensin-converting enzyme 2 (ACE2), one of the binding sites for SARS-CoV-2 infection in humans, can bind to viral spike proteins, allowing transmembrane serine protease (TMPRSS2) to activate S-protein to trigger infection and induce the production of various inflammatory factors such as interleukin-1, interferon-l, and tumor necrosis factor.	Serine	158-164	angiotensin converting enzyme 2	Homo sapiens	33-37
33260592-8	2020	Preliminary docking was more optimal to ACE2 than the known typical angiotensin-converting enzyme 1 (ACE1) inhibitor (enalapril) and quite comparable to known or presumed ACE2 inhibitors.	Enalapril	118-127	angiotensin converting enzyme 2	Homo sapiens	40-44
33330677-0	2020	Sacubitril/Valsartan: Potential Impact of ARNi "Beyond the Wall" of ACE2 on Treatment and Prognosis of Heart Failure Patients With Coronavirus Disease-19.	sacubitril and valsartan sodium hydrate drug combination	0-10	angiotensin converting enzyme 2	Homo sapiens	68-72
33330677-0	2020	Sacubitril/Valsartan: Potential Impact of ARNi "Beyond the Wall" of ACE2 on Treatment and Prognosis of Heart Failure Patients With Coronavirus Disease-19.	Valsartan	11-20	angiotensin converting enzyme 2	Homo sapiens	68-72
33179911-0	2020	Quercetin and Its Metabolites Inhibit Recombinant Human Angiotensin-Converting Enzyme 2 (ACE2) Activity.	Quercetin	0-9	angiotensin converting enzyme 2	Homo sapiens	56-87
33256258-3	2020	Moreover, indirect evidence points out to a possible antiviral action of melatonin by interfering with SARS-CoV-2/angiotensin-converting enzyme 2 association.	Melatonin	73-82	angiotensin converting enzyme 2	Homo sapiens	114-145
33234138-11	2020	Because the hormone 17ss-estradiol influences expression of the human angiotensin-converting enzyme 2 (ACE2) protein, which plays a role in SARS-CoV-2 cellular entry, propensity score matching was performed for the women"s sub-cohort, comparing users vs. non-users of estradiol.	17ss-estradiol	20-34	angiotensin converting enzyme 2	Homo sapiens	70-101
33234138-11	2020	Because the hormone 17ss-estradiol influences expression of the human angiotensin-converting enzyme 2 (ACE2) protein, which plays a role in SARS-CoV-2 cellular entry, propensity score matching was performed for the women"s sub-cohort, comparing users vs. non-users of estradiol.	17ss-estradiol	20-34	angiotensin converting enzyme 2	Homo sapiens	103-107
33234138-11	2020	Because the hormone 17ss-estradiol influences expression of the human angiotensin-converting enzyme 2 (ACE2) protein, which plays a role in SARS-CoV-2 cellular entry, propensity score matching was performed for the women"s sub-cohort, comparing users vs. non-users of estradiol.	Estradiol	25-34	angiotensin converting enzyme 2	Homo sapiens	70-101
33234138-11	2020	Because the hormone 17ss-estradiol influences expression of the human angiotensin-converting enzyme 2 (ACE2) protein, which plays a role in SARS-CoV-2 cellular entry, propensity score matching was performed for the women"s sub-cohort, comparing users vs. non-users of estradiol.	Estradiol	25-34	angiotensin converting enzyme 2	Homo sapiens	103-107
33179911-0	2020	Quercetin and Its Metabolites Inhibit Recombinant Human Angiotensin-Converting Enzyme 2 (ACE2) Activity.	Quercetin	0-9	angiotensin converting enzyme 2	Homo sapiens	89-93
33179911-3	2020	The objective of this study was to determine if flavonoids and other polyphenols with B-ring 3",4"-hydroxylation inhibit recombinant human (rh)ACE2 activity.	Flavonoids	48-58	angiotensin converting enzyme 2	Homo sapiens	143-147
33179911-3	2020	The objective of this study was to determine if flavonoids and other polyphenols with B-ring 3",4"-hydroxylation inhibit recombinant human (rh)ACE2 activity.	Polyphenols	69-80	angiotensin converting enzyme 2	Homo sapiens	143-147
33269348-5	2020	In a subset of this cohort we validated ACE2 protein expression and localization in formalin-fixed, paraffin-embedded matched colon and ileal tissues using immunohistochemistry.	Formaldehyde	84-92	angiotensin converting enzyme 2	Homo sapiens	40-44
33255849-7	2020	The results revealed that two amphibian AMPs, caerin 1.6 and caerin 1.10, had the highest affinity for Sgp proteins while interaction with the ACE2 receptor was reduced.	caerin	46-52	angiotensin converting enzyme 2	Homo sapiens	143-147
33139139-3	2020	Cynomolgus macaques (Macaca fascicularis) immunized with NVX-CoV2373 and the saponin-based Matrix-M  adjuvant induced anti-S antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor.	Saponins	77-84	angiotensin converting enzyme 2	Homo sapiens	189-220
33139139-3	2020	Cynomolgus macaques (Macaca fascicularis) immunized with NVX-CoV2373 and the saponin-based Matrix-M  adjuvant induced anti-S antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor.	Saponins	77-84	angiotensin converting enzyme 2	Homo sapiens	222-227
33269348-5	2020	In a subset of this cohort we validated ACE2 protein expression and localization in formalin-fixed, paraffin-embedded matched colon and ileal tissues using immunohistochemistry.	Paraffin	100-108	angiotensin converting enzyme 2	Homo sapiens	40-44
33269350-4	2021	Using an in vitro system, we demonstrate that the small molecule inhibitor ipomoeassin F (Ipom-F) potently blocks the Sec61-mediated ER membrane translocation/insertion of three therapeutic protein targets for SARS-CoV-2 infection; the viral spike and ORF8 proteins together with angiotensin-converting enzyme 2, the host cell plasma membrane receptor.	ipomoeassin F	75-88	angiotensin converting enzyme 2	Homo sapiens	280-311
33269350-4	2021	Using an in vitro system, we demonstrate that the small molecule inhibitor ipomoeassin F (Ipom-F) potently blocks the Sec61-mediated ER membrane translocation/insertion of three therapeutic protein targets for SARS-CoV-2 infection; the viral spike and ORF8 proteins together with angiotensin-converting enzyme 2, the host cell plasma membrane receptor.	ipomoeassin F	90-96	angiotensin converting enzyme 2	Homo sapiens	280-311
33203141-13	2020	Thus, NEP/angiotensin receptor type 1 (AT1R) inhibitor sacubitril/valsartan (SAC/VAL) may increase levels of these molecules and block AT1Rs required for ACE2 endocytosis in SARS-CoV-2 infection.	sacubitril and valsartan sodium hydrate drug combination	55-65	angiotensin converting enzyme 2	Homo sapiens	154-158
32442259-0	2020	Renin-angiotensin-aldosterone system inhibitors impact on COVID-19 mortality: What"s next for ACE2?	Aldosterone	18-29	angiotensin converting enzyme 2	Homo sapiens	94-98
33330557-12	2020	Studies have found that ACE2 and TMPRSS2 are expressed in the testis and male reproductive tract and are regulated by testosterone.	Testosterone	118-130	angiotensin converting enzyme 2	Homo sapiens	24-28
33245731-4	2020	We show MEK inhibitors (MEKi) VS-6766, trametinib and selumetinib reduce ACE2 expression in human cells.	trametinib	39-49	angiotensin converting enzyme 2	Homo sapiens	73-77
33245731-4	2020	We show MEK inhibitors (MEKi) VS-6766, trametinib and selumetinib reduce ACE2 expression in human cells.	AZD 6244	54-65	angiotensin converting enzyme 2	Homo sapiens	73-77
33245731-5	2020	In some human cells, remdesivir increases ACE2-promoter luciferase-reporter expression, ACE2 mRNA and protein, and ACE2 expression is attenuated by MEKi.	remdesivir	21-31	angiotensin converting enzyme 2	Homo sapiens	42-46
33245731-5	2020	In some human cells, remdesivir increases ACE2-promoter luciferase-reporter expression, ACE2 mRNA and protein, and ACE2 expression is attenuated by MEKi.	remdesivir	21-31	angiotensin converting enzyme 2	Homo sapiens	88-92
33245731-5	2020	In some human cells, remdesivir increases ACE2-promoter luciferase-reporter expression, ACE2 mRNA and protein, and ACE2 expression is attenuated by MEKi.	remdesivir	21-31	angiotensin converting enzyme 2	Homo sapiens	88-92
33245731-6	2020	In serum-deprived and stimulated cells treated with remdesivir and MEKi we observed correlations between pRB, pERK, and ACE2 expression further supporting role of proliferative state and MAPK pathway in ACE2 regulation.	remdesivir	52-62	angiotensin converting enzyme 2	Homo sapiens	120-124
33245731-6	2020	In serum-deprived and stimulated cells treated with remdesivir and MEKi we observed correlations between pRB, pERK, and ACE2 expression further supporting role of proliferative state and MAPK pathway in ACE2 regulation.	remdesivir	52-62	angiotensin converting enzyme 2	Homo sapiens	203-207
33235538-7	2021	Plasma-activated water after room-temperature storage of 30 days remained capable of significantly reducing the RBD binding with hACE2.	Water	17-22	angiotensin converting enzyme 2	Homo sapiens	129-134
33064147-5	2020	Research has shown that ACE2 regulates the expression of the neutral amino acid transporter B0AT1, controlling tryptophan-associated intestinal inflammation and nutritional status.	Tryptophan	111-121	angiotensin converting enzyme 2	Homo sapiens	24-28
33218024-6	2020	Among them, enalaprilat, an ACE inhibitor, showed a Kd value of 1.5 nM against the ACE2.	Enalaprilat	12-23	angiotensin converting enzyme 2	Homo sapiens	83-87
32926917-5	2020	ACE2 plays a protective role in the pulmonary system through its Mas-receptor and alamandine-MrgD-TGR7 pathways.	alamandine	82-92	angiotensin converting enzyme 2	Homo sapiens	0-4
32979436-3	2020	In the current study, a series of polysaccharides from Saccharina japonica were prepared to investigate the structure-activity relationship on the binding abilities of polysaccharides (oligosaccharides) to pseudotype particles, including SARS-CoV-2 SGPs, and ACE2 using surface plasmon resonance.	Polysaccharides	168-183	angiotensin converting enzyme 2	Homo sapiens	259-263
32979436-4	2020	Sulfated galactofucan (SJ-D-S-H) and glucuronomannan (Gn) displayed strongly inhibited interaction between SARS-CoV-2 SGPs and heparin while showing negligible inhibition of the interaction between SARS-CoV-2 SGPs and ACE2.	galactofucan	9-21	angiotensin converting enzyme 2	Homo sapiens	218-222
32979436-4	2020	Sulfated galactofucan (SJ-D-S-H) and glucuronomannan (Gn) displayed strongly inhibited interaction between SARS-CoV-2 SGPs and heparin while showing negligible inhibition of the interaction between SARS-CoV-2 SGPs and ACE2.	glucuronomannan	37-52	angiotensin converting enzyme 2	Homo sapiens	218-222
33203141-13	2020	Thus, NEP/angiotensin receptor type 1 (AT1R) inhibitor sacubitril/valsartan (SAC/VAL) may increase levels of these molecules and block AT1Rs required for ACE2 endocytosis in SARS-CoV-2 infection.	Valsartan	66-75	angiotensin converting enzyme 2	Homo sapiens	154-158
33203141-13	2020	Thus, NEP/angiotensin receptor type 1 (AT1R) inhibitor sacubitril/valsartan (SAC/VAL) may increase levels of these molecules and block AT1Rs required for ACE2 endocytosis in SARS-CoV-2 infection.	Valine	81-84	angiotensin converting enzyme 2	Homo sapiens	154-158
32970989-2	2020	Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-binding site.	Heparin	26-33	angiotensin converting enzyme 2	Homo sapiens	79-83
33135725-5	2020	In this review, we will focus on kidney ACE2; its localization, its alterations in hypertension, diabetes, the effect of ACE inhibitors and angiotensin type 1 receptor blockers (ARBs) on ACE2 and the potential use of ACE2 recombinant proteins therapeutically for kidney disease.	angiotensin type 1 receptor blockers	140-176	angiotensin converting enzyme 2	Homo sapiens	40-44
32970989-2	2020	Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-binding site.	Heparitin Sulfate	34-49	angiotensin converting enzyme 2	Homo sapiens	79-83
32970989-3	2020	Both ACE2 and heparin can bind independently to spike protein in vitro, and a ternary complex can be generated using heparin as a scaffold.	Heparin	117-124	angiotensin converting enzyme 2	Homo sapiens	5-9
32970989-4	2020	Electron micrographs of spike protein suggests that heparin enhances the open conformation of the RBD that binds ACE2.	Heparin	52-59	angiotensin converting enzyme 2	Homo sapiens	113-117
32970989-7	2020	We suggest a model in which viral attachment and infection involves heparan sulfate-dependent enhancement of binding to ACE2.	Heparitin Sulfate	68-83	angiotensin converting enzyme 2	Homo sapiens	120-124
32917722-0	2020	Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.	Sphingosine	0-11	angiotensin converting enzyme 2	Homo sapiens	74-78
33175236-7	2020	We found two natural origin inhibitors for the S protein: human ACE2 complex (Andrographolide and Pterostilbene) which displayed better inhibition potential for ACE2 receptor and its binding with the S protein of SARS-CoV-2.	andrographolide	78-93	angiotensin converting enzyme 2	Homo sapiens	64-68
33175236-7	2020	We found two natural origin inhibitors for the S protein: human ACE2 complex (Andrographolide and Pterostilbene) which displayed better inhibition potential for ACE2 receptor and its binding with the S protein of SARS-CoV-2.	andrographolide	78-93	angiotensin converting enzyme 2	Homo sapiens	161-165
33175236-7	2020	We found two natural origin inhibitors for the S protein: human ACE2 complex (Andrographolide and Pterostilbene) which displayed better inhibition potential for ACE2 receptor and its binding with the S protein of SARS-CoV-2.	pterostilbene	98-111	angiotensin converting enzyme 2	Homo sapiens	64-68
33175236-7	2020	We found two natural origin inhibitors for the S protein: human ACE2 complex (Andrographolide and Pterostilbene) which displayed better inhibition potential for ACE2 receptor and its binding with the S protein of SARS-CoV-2.	pterostilbene	98-111	angiotensin converting enzyme 2	Homo sapiens	161-165
33172372-0	2021	Tinocordiside from Tinospora cordifolia (Giloy) May Curb SARS-CoV-2 Contagion by Disrupting the Electrostatic Interactions between Host ACE2 and Viral S-Protein Receptor Binding Domain.	tinocordiside	0-13	angiotensin converting enzyme 2	Homo sapiens	136-140
33172372-4	2021	RESULTS: "Tinocordiside" docked very well at the center of the interface of ACE2-RBD complex, and was found to be well stabilized during MD simulation.	tinocordiside	10-23	angiotensin converting enzyme 2	Homo sapiens	76-80
33172372-5	2021	Tinocordiside incorporation significantly decreased electrostatic component of binding free energies of ACE2-RBD complex (23.5 and 17.10 kcal/mol in the trajectories without or with the ligand, respectively).	tinocordiside	0-13	angiotensin converting enzyme 2	Homo sapiens	104-108
33170175-4	2020	The spray contains hydroxytyrosol for its anti-viral, anti-inflammatory and anti-oxidant properties, and alpha-cyclodextrin for its ability to deplete sphingolipids, that form the lipid rafts where ACE2 localizes.	alpha-cyclodextrin	105-123	angiotensin converting enzyme 2	Homo sapiens	198-202
33170175-4	2020	The spray contains hydroxytyrosol for its anti-viral, anti-inflammatory and anti-oxidant properties, and alpha-cyclodextrin for its ability to deplete sphingolipids, that form the lipid rafts where ACE2 localizes.	Sphingolipids	151-164	angiotensin converting enzyme 2	Homo sapiens	198-202
33170176-11	2020	In addition, we identified possible interactions among hydroxytyrosol and alpha-cyclodextrin with the protein Spike and the human proteins ACE2 and TMPRSS2.	3,4-dihydroxyphenylethanol	55-69	angiotensin converting enzyme 2	Homo sapiens	139-143
33170176-11	2020	In addition, we identified possible interactions among hydroxytyrosol and alpha-cyclodextrin with the protein Spike and the human proteins ACE2 and TMPRSS2.	alpha-cyclodextrin	74-92	angiotensin converting enzyme 2	Homo sapiens	139-143
32551648-10	2020	Preliminary results on hepcidin (a molecule with strong structural and sequence with AMR) indicated an inhibitory effect on the binding affinity of the spike protein toward the ACE2 protein.	amr	85-88	angiotensin converting enzyme 2	Homo sapiens	177-181
32917722-5	2020	Mechanistically, we demonstrate that sphingosine binds to ACE2, the cellular receptor of SARS-CoV-2, and prevents the interaction of the receptor binding domain of the viral spike protein with ACE2.	Sphingosine	37-48	angiotensin converting enzyme 2	Homo sapiens	58-62
32917722-5	2020	Mechanistically, we demonstrate that sphingosine binds to ACE2, the cellular receptor of SARS-CoV-2, and prevents the interaction of the receptor binding domain of the viral spike protein with ACE2.	Sphingosine	37-48	angiotensin converting enzyme 2	Homo sapiens	193-197
32996784-0	2020	Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19?	Steroids	4-12	angiotensin converting enzyme 2	Homo sapiens	18-22
33298900-2	2020	Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated entry of SARS-Cov and CoV-2 requires the cell surface heparan sulfate (HS) as an assisting cofactor: ablation of genes involved in HS biosynthesis or incubating cells with a HS mimetic both inhibit Spike-mediated viral entry.	Heparitin Sulfate	139-154	angiotensin converting enzyme 2	Homo sapiens	71-75
33298900-2	2020	Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated entry of SARS-Cov and CoV-2 requires the cell surface heparan sulfate (HS) as an assisting cofactor: ablation of genes involved in HS biosynthesis or incubating cells with a HS mimetic both inhibit Spike-mediated viral entry.	Heparitin Sulfate	156-158	angiotensin converting enzyme 2	Homo sapiens	71-75
33171852-2	2020	The virus SARS-CoV-2 employs the Angiotensin-converting enzyme 2 (ACE2), a component of the RAAS (Renin-Angiotensin-Aldosterone System) system, as a receptor for entry into the cells.	Aldosterone	116-127	angiotensin converting enzyme 2	Homo sapiens	33-64
33171852-2	2020	The virus SARS-CoV-2 employs the Angiotensin-converting enzyme 2 (ACE2), a component of the RAAS (Renin-Angiotensin-Aldosterone System) system, as a receptor for entry into the cells.	Aldosterone	116-127	angiotensin converting enzyme 2	Homo sapiens	66-70
32996784-2	2020	In the current study, using primary isolated human airway smooth muscle (ASM) cells from normal males versus females as a model, we explored the effect of estrogen versus testosterone in modulating the expression of angiotensin converting enzyme 2 (ACE2), a cell entry point for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).	Testosterone	171-183	angiotensin converting enzyme 2	Homo sapiens	216-247
32996784-2	2020	In the current study, using primary isolated human airway smooth muscle (ASM) cells from normal males versus females as a model, we explored the effect of estrogen versus testosterone in modulating the expression of angiotensin converting enzyme 2 (ACE2), a cell entry point for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).	Testosterone	171-183	angiotensin converting enzyme 2	Homo sapiens	249-253
32996784-5	2020	In addition, ASM cells exposed to estrogen and testosterone for 24 h showed that testosterone significantly upregulates ACE2 expression in both males and females, whereas estrogen downregulates ACE2, albeit not significant compared with vehicle.	Testosterone	47-59	angiotensin converting enzyme 2	Homo sapiens	120-124
32996784-5	2020	In addition, ASM cells exposed to estrogen and testosterone for 24 h showed that testosterone significantly upregulates ACE2 expression in both males and females, whereas estrogen downregulates ACE2, albeit not significant compared with vehicle.	Testosterone	81-93	angiotensin converting enzyme 2	Homo sapiens	120-124
33011745-3	2020	Here, we determined the expression of the SARS-CoV2 receptor, angiotensin converting enzyme 2 (ACE2) and its associated cellular serine protease TPMRSS2 in the dental pulp under normal and inflamed conditions.	Serine	129-135	angiotensin converting enzyme 2	Homo sapiens	62-93
33140043-7	2020	Microsecond LiGaMD simulations have successfully captured both binding and unbinding of the MLN-4760 inhibitor in the ACE2 receptor.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	92-100	angiotensin converting enzyme 2	Homo sapiens	118-122
33011745-3	2020	Here, we determined the expression of the SARS-CoV2 receptor, angiotensin converting enzyme 2 (ACE2) and its associated cellular serine protease TPMRSS2 in the dental pulp under normal and inflamed conditions.	Serine	129-135	angiotensin converting enzyme 2	Homo sapiens	95-99
32853823-4	2020	The problem here is that in addition to be a receptor for the SARS-CoV-2 entry into the host cells, ACE2 acts as a key component of the renin-angiotensin-aldosterone system (RAAS) aimed at the generation of a cascade of vasoactive peptides coordinating several physiological processes.	Aldosterone	154-165	angiotensin converting enzyme 2	Homo sapiens	100-104
32981365-1	2020	ACE2 (angiotensin-converting enzyme 2) is a key component of the renin-angiotensin-aldosterone system.	Aldosterone	83-94	angiotensin converting enzyme 2	Homo sapiens	0-4
32981365-1	2020	ACE2 (angiotensin-converting enzyme 2) is a key component of the renin-angiotensin-aldosterone system.	Aldosterone	83-94	angiotensin converting enzyme 2	Homo sapiens	6-37
32981365-5	2020	We performed an association study of ACE2 against  5000 other plasma proteins measured with the SomaScan platform.	somascan	96-104	angiotensin converting enzyme 2	Homo sapiens	37-41
33254553-4	2020	In fact, in a single ACE2 molecule, 34 lysine residues are present in the extracellular portion, and at least one of these is co-involved in a fundamental hydrogen-bond interaction with the SARS-CoV-2 receptor binding domain (RBD).	Lysine	39-45	angiotensin converting enzyme 2	Homo sapiens	21-25
32965603-1	2020	Considerable concern has emerged for the potential harm in the use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor inhibitors (ARBs) in COVID-19 patients, given that ACEIs and ARBs may increase the expression of ACE2 receptors that represent the way for coronavirus 2 to entry into the cell and cause severe acute respiratory syndrome.	angiotensin receptor inhibitors	123-154	angiotensin converting enzyme 2	Homo sapiens	241-245
32965603-1	2020	Considerable concern has emerged for the potential harm in the use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor inhibitors (ARBs) in COVID-19 patients, given that ACEIs and ARBs may increase the expression of ACE2 receptors that represent the way for coronavirus 2 to entry into the cell and cause severe acute respiratory syndrome.	arbs	156-160	angiotensin converting enzyme 2	Homo sapiens	241-245
32965603-1	2020	Considerable concern has emerged for the potential harm in the use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor inhibitors (ARBs) in COVID-19 patients, given that ACEIs and ARBs may increase the expression of ACE2 receptors that represent the way for coronavirus 2 to entry into the cell and cause severe acute respiratory syndrome.	arbs	205-209	angiotensin converting enzyme 2	Homo sapiens	241-245
33254506-5	2020	The angiotensin converting enzyme-2 (ACE-2), a component in the renin-angiotensin-aldosterone system (RAAS), plays as cell surface receptors for SARS-CoV-2.	Aldosterone	82-93	angiotensin converting enzyme 2	Homo sapiens	4-35
33254506-5	2020	The angiotensin converting enzyme-2 (ACE-2), a component in the renin-angiotensin-aldosterone system (RAAS), plays as cell surface receptors for SARS-CoV-2.	Aldosterone	82-93	angiotensin converting enzyme 2	Homo sapiens	37-42
32966970-0	2020	Endocrine aspects of ACE2 regulation: RAAS, steroid hormones and SARS-CoV-2.	Steroids	44-51	angiotensin converting enzyme 2	Homo sapiens	21-25
32966970-4	2020	ACE2 is an established component of the "protective arm" of the renin-angiotensin-aldosterone-system (RAAS) that opposes ACE/angiotensin II (ANG II) pressor and tissue remodelling actions.	Aldosterone	82-93	angiotensin converting enzyme 2	Homo sapiens	0-4
32966970-4	2020	ACE2 is an established component of the "protective arm" of the renin-angiotensin-aldosterone-system (RAAS) that opposes ACE/angiotensin II (ANG II) pressor and tissue remodelling actions.	Angiotensin II	141-147	angiotensin converting enzyme 2	Homo sapiens	0-4
32739642-6	2020	The results of the calculations suggest that lividomycin, burixafor, quisinostat, fluprofylline, pemetrexed, spirofylline, edotecarin, and diniprofylline emerge as promising repositionable drug candidates for stabilizing the closed (substrate/inhibitor-bound) conformation of ACE2, thereby shifting the relative positions of the receptor"s critical exterior residues recognized by SARS-CoV-2.	lividomycin	45-56	angiotensin converting enzyme 2	Homo sapiens	276-280
32739642-6	2020	The results of the calculations suggest that lividomycin, burixafor, quisinostat, fluprofylline, pemetrexed, spirofylline, edotecarin, and diniprofylline emerge as promising repositionable drug candidates for stabilizing the closed (substrate/inhibitor-bound) conformation of ACE2, thereby shifting the relative positions of the receptor"s critical exterior residues recognized by SARS-CoV-2.	Spirofylline	109-121	angiotensin converting enzyme 2	Homo sapiens	276-280
32739642-6	2020	The results of the calculations suggest that lividomycin, burixafor, quisinostat, fluprofylline, pemetrexed, spirofylline, edotecarin, and diniprofylline emerge as promising repositionable drug candidates for stabilizing the closed (substrate/inhibitor-bound) conformation of ACE2, thereby shifting the relative positions of the receptor"s critical exterior residues recognized by SARS-CoV-2.	edotecarin	123-133	angiotensin converting enzyme 2	Homo sapiens	276-280
32739642-6	2020	The results of the calculations suggest that lividomycin, burixafor, quisinostat, fluprofylline, pemetrexed, spirofylline, edotecarin, and diniprofylline emerge as promising repositionable drug candidates for stabilizing the closed (substrate/inhibitor-bound) conformation of ACE2, thereby shifting the relative positions of the receptor"s critical exterior residues recognized by SARS-CoV-2.	diniprofylline	139-153	angiotensin converting enzyme 2	Homo sapiens	276-280
33254553-4	2020	In fact, in a single ACE2 molecule, 34 lysine residues are present in the extracellular portion, and at least one of these is co-involved in a fundamental hydrogen-bond interaction with the SARS-CoV-2 receptor binding domain (RBD).	Hydrogen	155-163	angiotensin converting enzyme 2	Homo sapiens	21-25
33254575-7	2020	ACE2 mediated dysregulation of sodium dependent glucose transporter (SGLT1 or SLC5A1) in the intestinal epithelium also links it to the pathogenesis of diabetes mellitus which can be a possible reason for the associated mortality in COVID-19 patients with diabetes.	Sodium	31-37	angiotensin converting enzyme 2	Homo sapiens	0-4
33254575-7	2020	ACE2 mediated dysregulation of sodium dependent glucose transporter (SGLT1 or SLC5A1) in the intestinal epithelium also links it to the pathogenesis of diabetes mellitus which can be a possible reason for the associated mortality in COVID-19 patients with diabetes.	Glucose	48-55	angiotensin converting enzyme 2	Homo sapiens	0-4
33254589-5	2020	Testosterone induces ACE-2 expression, a critical pulmonary protective enzyme.	Testosterone	0-12	angiotensin converting enzyme 2	Homo sapiens	21-26
32657529-11	2020	Higher serum aldosterone (ss=0.11 (SE 0.04;p<0.01) and urine AGT (ss=0.32 (SE 0.07;p<0.01) significantly associated with ACR and urine ACE2 (ss=0.21 (SE 0.13;p<0.03).	Aldosterone	13-24	angiotensin converting enzyme 2	Homo sapiens	135-139
32826754-8	2020	ACE2 mRNA is expressed by a subset of nociceptors that express MRGPRD mRNA, suggesting that SARS-CoV-2 may gain access to the nervous system through entry into neurons that form free nerve endings at the outermost layers of skin and luminal organs.	Phenobarbital	233-240	angiotensin converting enzyme 2	Homo sapiens	0-4
32866534-0	2020	Scaffold morphing of arbidol (umifenovir) in search of multi-targeting therapy halting the interaction of SARS-CoV-2 with ACE2 and other proteases involved in COVID-19.	umifenovir	21-28	angiotensin converting enzyme 2	Homo sapiens	122-126
32866534-0	2020	Scaffold morphing of arbidol (umifenovir) in search of multi-targeting therapy halting the interaction of SARS-CoV-2 with ACE2 and other proteases involved in COVID-19.	umifenovir	30-40	angiotensin converting enzyme 2	Homo sapiens	122-126
32866534-3	2020	The interaction of SP with ACE2 and these proteases results in the SARS-CoV-2 invasion and fast epidemic spread.	TFF2 protein, human	19-21	angiotensin converting enzyme 2	Homo sapiens	27-31
32866534-4	2020	The small molecular inhibitors are reported to limit the interaction of SP with ACE2 and other proteases.	TFF2 protein, human	72-74	angiotensin converting enzyme 2	Homo sapiens	80-84
33140034-6	2020	We reveal an essential structural role of N-glycans at sites N165 and N234 in modulating the conformational dynamics of the spike"s receptor binding domain (RBD), which is responsible for ACE2 recognition.	n-glycans	42-51	angiotensin converting enzyme 2	Homo sapiens	188-192
33142989-3	2020	This review provides a comprehensive summary of the role of ACE2 in the assembly of Na+-dependent transporters of glucose, imino and neutral amino acids, as well as the functions of ENaC.	Glucose	114-121	angiotensin converting enzyme 2	Homo sapiens	60-64
33142828-4	2020	Through its interactions with a multitude of cells, vitamin D may have several ways to reduce the risk of acute respiratory tract infections and COVID-19: reducing the survival and replication of viruses, reducing risk of inflammatory cytokine production, increasing angiotensin-converting enzyme 2 concentrations, and maintaining endothelial integrity.	Vitamin D	52-61	angiotensin converting enzyme 2	Homo sapiens	267-298
33125431-1	2020	Angiotensin-converting enzyme 2 (ACE2) has been implicated in the pathogenesis of chronic kidney disease (CKD) and is a membrane receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease (COVID-19), whereas transmembrane protease, serine 2 (TMPRSS2) is involved in viral attachment.	Serine	294-300	angiotensin converting enzyme 2	Homo sapiens	0-31
33125431-1	2020	Angiotensin-converting enzyme 2 (ACE2) has been implicated in the pathogenesis of chronic kidney disease (CKD) and is a membrane receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease (COVID-19), whereas transmembrane protease, serine 2 (TMPRSS2) is involved in viral attachment.	Serine	294-300	angiotensin converting enzyme 2	Homo sapiens	33-37
33140034-7	2020	This finding is corroborated by biolayer interferometry experiments, which show that deletion of these glycans through N165A and N234A mutations significantly reduces binding to ACE2 as a result of the RBD conformational shift toward the "down" state.	Polysaccharides	103-110	angiotensin converting enzyme 2	Homo sapiens	178-182
33103998-4	2020	We observed that N- and O-glycans had only minor contribution to Spike-ACE2 binding.	n- and o-glycans	17-33	angiotensin converting enzyme 2	Homo sapiens	71-75
33111624-9	2022	Also, in docking studies, the constituents of N. sativa, alpha-hederin, Thymohydroquinone and Thymoquinone were observed to be efficiently binding to ACE2.	beta-hederin	57-70	angiotensin converting enzyme 2	Homo sapiens	150-154
33111624-9	2022	Also, in docking studies, the constituents of N. sativa, alpha-hederin, Thymohydroquinone and Thymoquinone were observed to be efficiently binding to ACE2.	thymohydroquinone	72-89	angiotensin converting enzyme 2	Homo sapiens	150-154
33111624-9	2022	Also, in docking studies, the constituents of N. sativa, alpha-hederin, Thymohydroquinone and Thymoquinone were observed to be efficiently binding to ACE2.	thymoquinone	94-106	angiotensin converting enzyme 2	Homo sapiens	150-154
33103998-6	2020	Blocking N-glycan biosynthesis at the oligomannose stage using both genetic approaches and the small molecule kifunensine dramatically reduced viral entry into ACE2 expressing HEK293T cells.	n-glycan	9-17	angiotensin converting enzyme 2	Homo sapiens	160-164
33103998-6	2020	Blocking N-glycan biosynthesis at the oligomannose stage using both genetic approaches and the small molecule kifunensine dramatically reduced viral entry into ACE2 expressing HEK293T cells.	kifunensine	110-121	angiotensin converting enzyme 2	Homo sapiens	160-164
33104520-9	2020	As ACE2 expression is regulated by various conditions, including oxygen concentration, inflammation and smoking, caution is warranted to avoid triggering potential ACE2 expression in fetal and placental tissue.	Oxygen	65-71	angiotensin converting enzyme 2	Homo sapiens	3-7
33195060-4	2020	By combining an in silico approach and molecular in vitro testing we have been able to identify several triterpenoid/steroidal agents that inhibit interaction of the Spike RBD with the carboxypeptidase domain of the Angiotensin Converting Enzyme (ACE2).	Triterpenes	104-116	angiotensin converting enzyme 2	Homo sapiens	247-251
33114359-5	2020	ACE2 belongs to the renin-angiotensin system (RAS), composed of several peptides, such as angiotensin II (Ang II) and angiotensin (1-7) (Ang-(1-7)).	Peptides	72-80	angiotensin converting enzyme 2	Homo sapiens	0-4
33195415-16	2020	A positive correlation between ACE2 expression and immune neoantigen, TMB, and microsatellite instability was found in multiple cancers.	1,2,4,5-tetramethoxybenzene	70-73	angiotensin converting enzyme 2	Homo sapiens	31-35
33103586-8	2022	The constant velocity steered molecular dynamics (SMD) simulations show that silodosin preferentially interacts with the RBD S1 and has potential to act as an interfering compound between viral spike-host ACE2 interactions.	silodosin	77-86	angiotensin converting enzyme 2	Homo sapiens	205-209
33193684-8	2020	All the eight compounds can effectively interfere with the binding of ACE2 and Spike protein, especially Nelfinavir, providing drug candidates for the treatment and prevention of SARS-CoV-2, suggesting further assessment of the anti-SARS-CoV-2 activity of these compounds in cell culture.	Nelfinavir	105-115	angiotensin converting enzyme 2	Homo sapiens	70-74
33106801-6	2020	The spike and ACE2 proteins are highly glycosylated with sialic acid modifications that direct viral-host interactions and infection.	N-Acetylneuraminic Acid	57-68	angiotensin converting enzyme 2	Homo sapiens	14-18
33195415-17	2020	GSEA analysis which was carried out to determine the effect of ACE2 on tumors indicated that several cancer-associated pathways and immune-related pathways were hyperactivated in the high ACE2 expression group of most tumors.	gsea	0-4	angiotensin converting enzyme 2	Homo sapiens	63-67
33195415-17	2020	GSEA analysis which was carried out to determine the effect of ACE2 on tumors indicated that several cancer-associated pathways and immune-related pathways were hyperactivated in the high ACE2 expression group of most tumors.	gsea	0-4	angiotensin converting enzyme 2	Homo sapiens	188-192
33525222-8	2020	As to smoking, nicotine activation of nicotinic receptors leads to enhanced protease activation, apoptosis and inflammatory signaling through the same pathways (Renin-angiotensin system (RAS) and angiotensin-converting enzyme 2 (ACE2)) used by the virus increasing the inflammatory/destructive action of the virus itself.	Nicotine	15-23	angiotensin converting enzyme 2	Homo sapiens	196-227
33089728-0	2022	Prevention of SARS-CoV-2 cell entry: insight from in silico interaction of drug-like alkaloids with spike glycoprotein, human ACE2, and TMPRSS2.	Alkaloids	85-94	angiotensin converting enzyme 2	Homo sapiens	126-130
33089728-5	2022	These alkaloids were docked for their interactions with SARS-CoV-2 spike glycoprotein, ACE2, and TMPRSS2.	Alkaloids	6-15	angiotensin converting enzyme 2	Homo sapiens	87-91
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	150-158	angiotensin converting enzyme 2	Homo sapiens	0-31
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	150-158	angiotensin converting enzyme 2	Homo sapiens	33-38
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	159-167	angiotensin converting enzyme 2	Homo sapiens	0-31
33525222-8	2020	As to smoking, nicotine activation of nicotinic receptors leads to enhanced protease activation, apoptosis and inflammatory signaling through the same pathways (Renin-angiotensin system (RAS) and angiotensin-converting enzyme 2 (ACE2)) used by the virus increasing the inflammatory/destructive action of the virus itself.	Nicotine	15-23	angiotensin converting enzyme 2	Homo sapiens	229-233
33080900-0	2020	In silico Investigation on the Inhibiting Role of Nicotine/Caffeine by Blocking the S Protein of SARS-CoV-2 Versus ACE2 Receptor.	Nicotine	50-58	angiotensin converting enzyme 2	Homo sapiens	115-119
33077836-5	2020	In this paper five phytochemicals, which belong to flavonoid and anthraquinone subclass, have been selected as small molecules in molecular docking study of spike protein of SARS-CoV2 with its human receptor ACE2 molecule.	Flavonoids	51-60	angiotensin converting enzyme 2	Homo sapiens	208-212
33077836-5	2020	In this paper five phytochemicals, which belong to flavonoid and anthraquinone subclass, have been selected as small molecules in molecular docking study of spike protein of SARS-CoV2 with its human receptor ACE2 molecule.	Anthraquinones	65-78	angiotensin converting enzyme 2	Homo sapiens	208-212
33077836-8	2020	Among them, the phytochemical hesperidin can bind with ACE2 protein and bound structure of ACE2 protein and spike protein of SARS-CoV2 noncompetitively.	Hesperidin	30-40	angiotensin converting enzyme 2	Homo sapiens	55-59
33077836-8	2020	Among them, the phytochemical hesperidin can bind with ACE2 protein and bound structure of ACE2 protein and spike protein of SARS-CoV2 noncompetitively.	Hesperidin	30-40	angiotensin converting enzyme 2	Homo sapiens	91-95
33077836-12	2020	This result indicates that due to presence of hesperidin, the bound structure of ACE2 and spike protein fragment becomes unstable.	Hesperidin	46-56	angiotensin converting enzyme 2	Homo sapiens	81-85
33080900-7	2020	Our MD simulations suggest that the combination of caffeine with ribavirin shows a stronger interaction with 6VW1, while in case of favipiravir+nicotine, 6LZG shows potent efficacy of these interaction, proposing the potent efficacy of these combinations for blocking ACE2 receptor against SARS-CoV-2.	Caffeine	51-59	angiotensin converting enzyme 2	Homo sapiens	268-272
33080900-7	2020	Our MD simulations suggest that the combination of caffeine with ribavirin shows a stronger interaction with 6VW1, while in case of favipiravir+nicotine, 6LZG shows potent efficacy of these interaction, proposing the potent efficacy of these combinations for blocking ACE2 receptor against SARS-CoV-2.	Ribavirin	65-74	angiotensin converting enzyme 2	Homo sapiens	268-272
33073699-7	2022	The results suggested that amarogentin, eufoliatorin, alpha-amyrin, caesalpinins, kutkin, beta-sitosterol, and belladonnine are the top-ranked molecules have the highest affinity towards both the spike glycoprotein and ACE2.	amarogentin	27-38	angiotensin converting enzyme 2	Homo sapiens	219-223
33073699-7	2022	The results suggested that amarogentin, eufoliatorin, alpha-amyrin, caesalpinins, kutkin, beta-sitosterol, and belladonnine are the top-ranked molecules have the highest affinity towards both the spike glycoprotein and ACE2.	Eufoliatorin	40-52	angiotensin converting enzyme 2	Homo sapiens	219-223
33073699-7	2022	The results suggested that amarogentin, eufoliatorin, alpha-amyrin, caesalpinins, kutkin, beta-sitosterol, and belladonnine are the top-ranked molecules have the highest affinity towards both the spike glycoprotein and ACE2.	beta-amyrin	54-66	angiotensin converting enzyme 2	Homo sapiens	219-223
33073699-7	2022	The results suggested that amarogentin, eufoliatorin, alpha-amyrin, caesalpinins, kutkin, beta-sitosterol, and belladonnine are the top-ranked molecules have the highest affinity towards both the spike glycoprotein and ACE2.	caesalpinins	68-80	angiotensin converting enzyme 2	Homo sapiens	219-223
33073699-7	2022	The results suggested that amarogentin, eufoliatorin, alpha-amyrin, caesalpinins, kutkin, beta-sitosterol, and belladonnine are the top-ranked molecules have the highest affinity towards both the spike glycoprotein and ACE2.	kutkin	82-88	angiotensin converting enzyme 2	Homo sapiens	219-223
33073699-7	2022	The results suggested that amarogentin, eufoliatorin, alpha-amyrin, caesalpinins, kutkin, beta-sitosterol, and belladonnine are the top-ranked molecules have the highest affinity towards both the spike glycoprotein and ACE2.	gamma-sitosterol	90-105	angiotensin converting enzyme 2	Homo sapiens	219-223
33073699-7	2022	The results suggested that amarogentin, eufoliatorin, alpha-amyrin, caesalpinins, kutkin, beta-sitosterol, and belladonnine are the top-ranked molecules have the highest affinity towards both the spike glycoprotein and ACE2.	Belladonnine	111-123	angiotensin converting enzyme 2	Homo sapiens	219-223
33080900-0	2020	In silico Investigation on the Inhibiting Role of Nicotine/Caffeine by Blocking the S Protein of SARS-CoV-2 Versus ACE2 Receptor.	Caffeine	59-67	angiotensin converting enzyme 2	Homo sapiens	115-119
33080900-1	2020	In this paper, we studied the in silico interaction of angiotensin-converting enzyme 2 (ACE2) human receptor with two bioactive compounds, i.e., nicotine and caffeine, via molecular dynamic (MD) simulations.	Nicotine	145-153	angiotensin converting enzyme 2	Homo sapiens	55-86
33080900-1	2020	In this paper, we studied the in silico interaction of angiotensin-converting enzyme 2 (ACE2) human receptor with two bioactive compounds, i.e., nicotine and caffeine, via molecular dynamic (MD) simulations.	Nicotine	145-153	angiotensin converting enzyme 2	Homo sapiens	88-92
33080900-1	2020	In this paper, we studied the in silico interaction of angiotensin-converting enzyme 2 (ACE2) human receptor with two bioactive compounds, i.e., nicotine and caffeine, via molecular dynamic (MD) simulations.	Caffeine	158-166	angiotensin converting enzyme 2	Homo sapiens	55-86
33080900-1	2020	In this paper, we studied the in silico interaction of angiotensin-converting enzyme 2 (ACE2) human receptor with two bioactive compounds, i.e., nicotine and caffeine, via molecular dynamic (MD) simulations.	Caffeine	158-166	angiotensin converting enzyme 2	Homo sapiens	88-92
33080900-2	2020	The simulations reveal the efficient blocking of ACE2 by caffeine and nicotine in the exposure to the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).	Caffeine	57-65	angiotensin converting enzyme 2	Homo sapiens	49-53
33080900-2	2020	The simulations reveal the efficient blocking of ACE2 by caffeine and nicotine in the exposure to the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).	Nicotine	70-78	angiotensin converting enzyme 2	Homo sapiens	49-53
33080900-3	2020	We have selected the two most important active sites of ACE2-S protein, i.e., 6LZG and 6VW1, which are critically responsible in the interaction of S protein to the receptor and thus, we investigated their interaction with nicotine and caffeine through MD simulations.	Nicotine	223-231	angiotensin converting enzyme 2	Homo sapiens	56-60
33080900-3	2020	We have selected the two most important active sites of ACE2-S protein, i.e., 6LZG and 6VW1, which are critically responsible in the interaction of S protein to the receptor and thus, we investigated their interaction with nicotine and caffeine through MD simulations.	Caffeine	236-244	angiotensin converting enzyme 2	Homo sapiens	56-60
33080900-6	2020	Further, we investigated the interaction of ACE2 receptor- S protein with nicotine or caffeine when mixed with candidate or approved antiviral drugs for SARS-CoV-2 therapy.	Nicotine	74-82	angiotensin converting enzyme 2	Homo sapiens	44-48
33173592-4	2020	Taking into account the mechanisms of hydrophobic interaction, hydration shell, surface tension, and the shielding effect of water molecules, this study reveals a hydrophobic-interaction-based mechanism by means of which SARS-CoV-2 S and ACE2 bind together in an aqueous environment.	Water	125-130	angiotensin converting enzyme 2	Homo sapiens	238-242
32878881-6	2020	In silico screening, molecular mechanics and molecular dynamics simulation (MDS) analysis suggest ribavirin, ascorbate, lopinavir and hydroxychloroquine have strong interaction at the RBD-hACE2 interface.	Ribavirin	98-107	angiotensin converting enzyme 2	Homo sapiens	188-193
32878881-6	2020	In silico screening, molecular mechanics and molecular dynamics simulation (MDS) analysis suggest ribavirin, ascorbate, lopinavir and hydroxychloroquine have strong interaction at the RBD-hACE2 interface.	Ascorbic Acid	109-118	angiotensin converting enzyme 2	Homo sapiens	188-193
32878881-6	2020	In silico screening, molecular mechanics and molecular dynamics simulation (MDS) analysis suggest ribavirin, ascorbate, lopinavir and hydroxychloroquine have strong interaction at the RBD-hACE2 interface.	Lopinavir	120-129	angiotensin converting enzyme 2	Homo sapiens	188-193
32878881-6	2020	In silico screening, molecular mechanics and molecular dynamics simulation (MDS) analysis suggest ribavirin, ascorbate, lopinavir and hydroxychloroquine have strong interaction at the RBD-hACE2 interface.	Hydroxychloroquine	134-152	angiotensin converting enzyme 2	Homo sapiens	188-193
33194061-10	2020	Further logistic regression analysis showed that TPNT was highly associated with serum TG level and hypertension that were related to the expression of ACE2, the targeting protein for the invasion of SARS-CoV-2.	Triglycerides	87-89	angiotensin converting enzyme 2	Homo sapiens	152-156
33030073-4	2020	According to the obtained evidence, Vitamin D (VitD) enhances the ACE2/Ang(1-7)/MasR pathway activity, and it also reduces cytokine storms and the ARS risk.	Vitamin D	36-45	angiotensin converting enzyme 2	Homo sapiens	66-70
33053830-0	2020	Docking and QSAR of Aminothioureas at the SARS-CoV-2 S-Protein-Human ACE2 Receptor Interface.	aminothioureas	20-34	angiotensin converting enzyme 2	Homo sapiens	69-73
33053830-1	2020	Docking of over 160 aminothiourea derivatives at the SARS-CoV-2 S-protein-human ACE2 receptor interface, whose structure became available recently, has been evaluated for its complex stabilizing potency and subsequently subjected to quantitative structure-activity relationship (QSAR) analysis.	thiosemicarbazide	20-33	angiotensin converting enzyme 2	Homo sapiens	80-84
33066495-5	2020	As such, this paper focuses on the potential role of BPA in promoting comorbidities associated with severe COVID-19, as well as on potential BPA-induced effects on key SARS-CoV-2 infection mediators, such as angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2).	bisphenol A	141-144	angiotensin converting enzyme 2	Homo sapiens	208-239
33116543-10	2020	Conclusion: Co-administration of fluoxetine in the treatment of COVID19 could be considered due to the possibility of its interaction with ACE2 receptors, immune-modulatory function, and a proper immune response at the right time.	Fluoxetine	33-43	angiotensin converting enzyme 2	Homo sapiens	139-143
33173846-3	2020	Here, a computational strategy is developed to adaptively evolve peptides that could selectively inhibit mutating S protein receptor binding domains (RBDs) of different SARS-CoV-2 viral strains from binding to their human host receptor, angiotensin-converting enzyme 2 (ACE2).	Peptides	65-73	angiotensin converting enzyme 2	Homo sapiens	237-268
33173846-3	2020	Here, a computational strategy is developed to adaptively evolve peptides that could selectively inhibit mutating S protein receptor binding domains (RBDs) of different SARS-CoV-2 viral strains from binding to their human host receptor, angiotensin-converting enzyme 2 (ACE2).	Peptides	65-73	angiotensin converting enzyme 2	Homo sapiens	270-274
32841605-4	2020	Our results highlight roles for glycans in sterically masking polypeptide epitopes and directly modulating Spike-ACE2 interactions.	Polysaccharides	32-39	angiotensin converting enzyme 2	Homo sapiens	113-117
33030105-0	2022	Molecular dynamics analysis predicts ritonavir and naloxegol strongly block the SARS-CoV-2 spike protein-hACE2 binding.	Ritonavir	37-46	angiotensin converting enzyme 2	Homo sapiens	105-110
33030105-0	2022	Molecular dynamics analysis predicts ritonavir and naloxegol strongly block the SARS-CoV-2 spike protein-hACE2 binding.	naloxegol	51-60	angiotensin converting enzyme 2	Homo sapiens	105-110
33030105-9	2022	Finally, a long MD analysis revealed two select candidate ligands, including ritonavir and naloxegol, highly stabilizing those key residues engaged in RBD-hACE2 interaction.	Ritonavir	77-86	angiotensin converting enzyme 2	Homo sapiens	155-160
33030105-9	2022	Finally, a long MD analysis revealed two select candidate ligands, including ritonavir and naloxegol, highly stabilizing those key residues engaged in RBD-hACE2 interaction.	naloxegol	91-100	angiotensin converting enzyme 2	Homo sapiens	155-160
32736832-6	2020	AT1R antagonists and vitamin D increase the expression of ACE2 independently.	Vitamin D	21-30	angiotensin converting enzyme 2	Homo sapiens	58-62
33471718-2	2020	Metformin increases the expression of angiotensin converting enzyme 2, a known receptor for severe acute respiratory syndrome coronavirus 2.	Metformin	0-9	angiotensin converting enzyme 2	Homo sapiens	38-69
32878480-4	2020	To date, no study has examined whether an increased fraction of inspired oxygen (FiO2) may affect the expression of SARS-CoV-2 entry receptors and co-receptors, including ACE2 and the transmembrane serine proteases TMPRSS1, TMPRSS2, and TMPRSS11D.	fio2	81-85	angiotensin converting enzyme 2	Homo sapiens	171-175
33117437-3	2020	The observed role of androgens in transcription of transmembrane protease serine-2, which facilitates COVID-19 anchoring to angiotensin-converting enzyme 2 cell surface receptors, seems to suggest that higher testosterone levels might be detrimental for outcomes.	Testosterone	209-221	angiotensin converting enzyme 2	Homo sapiens	124-155
33117441-5	2020	Mechanistically, hydroxychloroquine inhibits SARS-CoV-2 virus uptake into cells by inhibiting angiotensin-converting enzyme 2 glycosylation.	Hydroxychloroquine	17-35	angiotensin converting enzyme 2	Homo sapiens	94-125
32780893-6	2020	Thiols block the angiotensin-converting enzyme 2 thereby hampering penetration of SARS-CoV-2 into cells.	Sulfhydryl Compounds	0-6	angiotensin converting enzyme 2	Homo sapiens	17-48
32506743-2	2020	It has been hypothesized that ACE2 expression can be increased by Ibuprofen leading to a higher risk for severe COVID-19 (1).	Ibuprofen	66-75	angiotensin converting enzyme 2	Homo sapiens	30-34
33083627-10	2020	Based on in silico analysis, the lead compounds scrutinized herewith interact with S, hence, can prevent its internalization in cell using ACE2 and GRP78 receptor.The compounds predicted in this study are based on rigorous computational analysis and the evaluation of predicted lead compounds can be promising in experimental studies.	Sulfur	83-84	angiotensin converting enzyme 2	Homo sapiens	139-143
32797326-8	2020	Furthermore, in vitro studies suggest ibuprofen may facilitate cleavage of ACE2 from the membrane, preventing membrane-dependent viral entry into the cell, the clinical significance of which is uncertain.	Ibuprofen	38-47	angiotensin converting enzyme 2	Homo sapiens	75-79
32758625-4	2020	The severity of COVID-19 disease intensifies in patients with elevated glucose level probably via amplified pro-inflammatory cytokine response, poor innate immunity and downregulated angiotensin-converting enzyme 2.	Glucose	71-78	angiotensin converting enzyme 2	Homo sapiens	183-214
32519164-4	2020	Virus triggers the synthesis and release of pro-inflammatory cytokines, including IL-6 and TNF-alpha and also promotes downregulation of ACE-2, which promotes a concomitant increase in levels of angiotensin II (AT-II).	Astatine	211-213	angiotensin converting enzyme 2	Homo sapiens	137-142
32721181-8	2020	Moreover, a bidirectional relationship exists between the metabolism of NAD and the protective role that angiotensin converting enzyme 2, the COVID-19 receptor, can play against hyperinflammation.	NAD	72-75	angiotensin converting enzyme 2	Homo sapiens	105-136
33017914-3	2020	ALA reduces ADAM17 activity and ACE2 upregulation.	Thioctic Acid	0-3	angiotensin converting enzyme 2	Homo sapiens	32-36
32945396-4	2020	In vitro, ACE2 attenuated high-glucose-induced tubular epithelial to mesenchymal cell transition (EMT), which was demonstrated by increased expression of alpha-SMA and loss of E-cadherin expression, as demonstrated by western blot analysis and reverse transcription-quantitative PCR.	Glucose	31-38	angiotensin converting enzyme 2	Homo sapiens	10-14
32945396-5	2020	Adenovirus-mediated ACE2 overexpression was also revealed to significantly inhibit Arkadia expression and alleviated high-glucose-induced EMT, while ACE2 inhibition had the opposite effects.	Glucose	122-129	angiotensin converting enzyme 2	Homo sapiens	20-24
32945396-7	2020	In conclusion, ACE2 is protective in DN, which may be due to the inhibition of Arkadia-mediated Smad7 degradation, whereby TGF-beta/Smad-mediated EMT is ameliorated in high-glucose-stimulated HRPTEpiCs.	Glucose	173-180	angiotensin converting enzyme 2	Homo sapiens	15-19
32800589-4	2020	Considering that angiotensin-converting enzyme 2 (ACE2) is the principal enzyme for the production of Ang-(1-7), here we evaluate the cardiovascular reactivity to acute stress after administration of the ACE2 activator, diminazene aceturate (DIZE) into the BLA.	diminazene aceturate	220-240	angiotensin converting enzyme 2	Homo sapiens	17-48
32800589-4	2020	Considering that angiotensin-converting enzyme 2 (ACE2) is the principal enzyme for the production of Ang-(1-7), here we evaluate the cardiovascular reactivity to acute stress after administration of the ACE2 activator, diminazene aceturate (DIZE) into the BLA.	diminazene aceturate	220-240	angiotensin converting enzyme 2	Homo sapiens	50-54
32800589-4	2020	Considering that angiotensin-converting enzyme 2 (ACE2) is the principal enzyme for the production of Ang-(1-7), here we evaluate the cardiovascular reactivity to acute stress after administration of the ACE2 activator, diminazene aceturate (DIZE) into the BLA.	diminazene aceturate	242-246	angiotensin converting enzyme 2	Homo sapiens	17-48
32721806-0	2020	Spironolactone may provide protection from SARS-CoV-2: Targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS).	Spironolactone	0-14	angiotensin converting enzyme 2	Homo sapiens	76-107
32721806-0	2020	Spironolactone may provide protection from SARS-CoV-2: Targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS).	Spironolactone	0-14	angiotensin converting enzyme 2	Homo sapiens	109-113
32721806-5	2020	Current data shows that spironolactone may concurrently mitigate abnormal ACE2 expression, correct the balances membrane-attached and free circulating ACE2 and between angiotensin II and Angiotensin-(1-7) (Ang-(1-7)), suppress androgen-mediated TMPRSS2 activity, and inhibit obesity-related RAAS dysfunctions, with consequent decrease of viral priming.	Spironolactone	24-38	angiotensin converting enzyme 2	Homo sapiens	74-78
32721806-5	2020	Current data shows that spironolactone may concurrently mitigate abnormal ACE2 expression, correct the balances membrane-attached and free circulating ACE2 and between angiotensin II and Angiotensin-(1-7) (Ang-(1-7)), suppress androgen-mediated TMPRSS2 activity, and inhibit obesity-related RAAS dysfunctions, with consequent decrease of viral priming.	Spironolactone	24-38	angiotensin converting enzyme 2	Homo sapiens	151-155
32800589-4	2020	Considering that angiotensin-converting enzyme 2 (ACE2) is the principal enzyme for the production of Ang-(1-7), here we evaluate the cardiovascular reactivity to acute stress after administration of the ACE2 activator, diminazene aceturate (DIZE) into the BLA.	diminazene aceturate	242-246	angiotensin converting enzyme 2	Homo sapiens	50-54
32833435-0	2020	Computational Alanine Scanning and Structural Analysis of the SARS-CoV-2 Spike Protein/Angiotensin-Converting Enzyme 2 Complex.	Alanine	14-21	angiotensin converting enzyme 2	Homo sapiens	87-118
33020722-4	2020	We further resolved the cryo-electron microscopy (cryo-EM) structure of the cat ACE2 (cACE2) in complex with the SARS-CoV-2 RBD at a resolution of 3 A, revealing similar binding mode as hACE2 to the SARS-CoV-2 RBD.	cace2	86-91	angiotensin converting enzyme 2	Homo sapiens	80-84
33020722-4	2020	We further resolved the cryo-electron microscopy (cryo-EM) structure of the cat ACE2 (cACE2) in complex with the SARS-CoV-2 RBD at a resolution of 3 A, revealing similar binding mode as hACE2 to the SARS-CoV-2 RBD.	cace2	86-91	angiotensin converting enzyme 2	Homo sapiens	186-191
32992731-2	2020	Proposed mechanisms involve host cell membrane-bound angiotensin-converting enzyme 2 (ACE2), type II transmembrane serine proteases (TTSPs), such as transmembrane serine protease isoform 2 (TMPRSS2), lysosomal endopeptidase Cathepsin L (CTSL), subtilisin-like proprotein peptidase furin (FURIN), and even potentially membrane bound heparan sulfate proteoglycans.	Serine	163-169	angiotensin converting enzyme 2	Homo sapiens	53-84
32992731-2	2020	Proposed mechanisms involve host cell membrane-bound angiotensin-converting enzyme 2 (ACE2), type II transmembrane serine proteases (TTSPs), such as transmembrane serine protease isoform 2 (TMPRSS2), lysosomal endopeptidase Cathepsin L (CTSL), subtilisin-like proprotein peptidase furin (FURIN), and even potentially membrane bound heparan sulfate proteoglycans.	Heparitin Sulfate	332-347	angiotensin converting enzyme 2	Homo sapiens	53-84
32992731-2	2020	Proposed mechanisms involve host cell membrane-bound angiotensin-converting enzyme 2 (ACE2), type II transmembrane serine proteases (TTSPs), such as transmembrane serine protease isoform 2 (TMPRSS2), lysosomal endopeptidase Cathepsin L (CTSL), subtilisin-like proprotein peptidase furin (FURIN), and even potentially membrane bound heparan sulfate proteoglycans.	Heparitin Sulfate	332-347	angiotensin converting enzyme 2	Homo sapiens	86-90
32833435-2	2020	SARS-CoV-2 host cell entry is mediated by the interaction of the viral transmembrane spike glycoprotein (S-protein) with the angiotensin-converting enzyme 2 gene (ACE2), an essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis.	angiotensin hormone	232-251	angiotensin converting enzyme 2	Homo sapiens	125-156
32833435-2	2020	SARS-CoV-2 host cell entry is mediated by the interaction of the viral transmembrane spike glycoprotein (S-protein) with the angiotensin-converting enzyme 2 gene (ACE2), an essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis.	angiotensin hormone	232-251	angiotensin converting enzyme 2	Homo sapiens	163-167
32967280-2	2020	ACE2 downregulation affects the levels of diverse peptide mediators of the renin-agiotensin-aldestosterone and kallikrein-kinin systems, compromising vascular hemostasis.	agiotensin	81-91	angiotensin converting enzyme 2	Homo sapiens	0-4
32960159-8	2022	The binding energy which largely arises from van der Waals interactions is calculated (ACE2=-50.21 +- 6.3, Mpro=-89.50 +- 6.32 and spike=-23.06 +- 4.39) through molecular mechanics Poisson-Boltzmann surface area also confirm the affinity of procyanidin towards the critical receptors.	procyanidin	241-252	angiotensin converting enzyme 2	Homo sapiens	87-91
32967280-2	2020	ACE2 downregulation affects the levels of diverse peptide mediators of the renin-agiotensin-aldestosterone and kallikrein-kinin systems, compromising vascular hemostasis.	aldestosterone	92-106	angiotensin converting enzyme 2	Homo sapiens	0-4
32982622-0	2021	Air pollution by NO2 and PM2.5 explains COVID-19 infection severity by overexpression of angiotensin-converting enzyme 2 in respiratory cells: a review.	Nitrogen Dioxide	17-20	angiotensin converting enzyme 2	Homo sapiens	89-120
32957884-5	2021	Previous studies have shown that quercetin reduces the entry of the virus into the cell by blocking the ACE2 receptor, as well as reducing the level of interleukin-6 in SARS and MERS patients.	Quercetin	33-42	angiotensin converting enzyme 2	Homo sapiens	104-108
32982622-6	2021	High ACE-2 expression in respiratory epithelial cells under air pollution explains the positive correlation between the severity in COVID-19 patients and elevated air pollution, notably high NO2 and PM2.5 levels.	Nitrogen Dioxide	191-194	angiotensin converting enzyme 2	Homo sapiens	5-10
32982622-6	2021	High ACE-2 expression in respiratory epithelial cells under air pollution explains the positive correlation between the severity in COVID-19 patients and elevated air pollution, notably high NO2 and PM2.5 levels.	[4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE	199-202	angiotensin converting enzyme 2	Homo sapiens	5-10
33042994-8	2020	Following the binding of the S1 receptor-binding domain (RBD) to ACE2, transmembrane protease/serine subfamily 2 (TMPRSS2) cleaves the S2 domain to facilitate membrane fusion.	Serine	94-100	angiotensin converting enzyme 2	Homo sapiens	65-69
32703908-4	2020	Importantly, H014 administration reduced SARS-CoV-2 titers in the infected lungs and prevented pulmonary pathology in hACE2 mouse model.	h014	13-17	angiotensin converting enzyme 2	Homo sapiens	118-123
32947927-4	2020	The proposed pathophysiological mechanisms of myocardial impairment include invasion of SARS-CoV-2 virus via angiotensin-converting enzyme 2 to cardiovascular cells/tissue, which leads to endothelial inflammation and dysfunction, de-stabilization of vulnerable atherosclerotic plaques, stent thrombosis, cardiac stress due to diminish oxygen supply and cardiac muscle damage, and myocardial infarction.	Oxygen	335-341	angiotensin converting enzyme 2	Homo sapiens	109-140
33193695-7	2020	Ribavirin was predicted to be the best small molecular drug, with a higher molecular binding energy of -6.39 kcal/mol with human angiotensin-converting enzyme 2 (ACE2), followed by remdesivir (-7.4 kcal/mol), mycophenolic acid (-5.35 kcal/mol), and chloroquine (-6.29 kcal/mol).	Ribavirin	0-9	angiotensin converting enzyme 2	Homo sapiens	129-160
33193695-7	2020	Ribavirin was predicted to be the best small molecular drug, with a higher molecular binding energy of -6.39 kcal/mol with human angiotensin-converting enzyme 2 (ACE2), followed by remdesivir (-7.4 kcal/mol), mycophenolic acid (-5.35 kcal/mol), and chloroquine (-6.29 kcal/mol).	Ribavirin	0-9	angiotensin converting enzyme 2	Homo sapiens	162-166
32915649-5	2020	Finally, molecular docking simulations were performed to study matrine-Mpro, matrine-ACE2, and matrine-RdRp interactions.	matrine	77-84	angiotensin converting enzyme 2	Homo sapiens	85-89
33193695-9	2020	In addition, for the first time, our results suggested several antiviral drugs, such as FK506, with molecular binding energies of -11.06 and -10.1 kcal/mol with ACE2 and the spike protein, respectively, could be potentially used to prevent SARS-CoV-2 and remains to further validation.	Tacrolimus	88-93	angiotensin converting enzyme 2	Homo sapiens	161-165
32712300-3	2020	The use of ACEIs/ARBs (RAAS inhibitors) regulates the renin-angiotensin-aldosterone system (RAAS) and may increase ACE2 expression.	aceis	11-16	angiotensin converting enzyme 2	Homo sapiens	115-119
32712300-5	2020	In this review, we summarize preclinical and clinical studies to investigate whether the use of ACEIs/ARBs increases ACE2 expression in animals or patients.	aceis	96-101	angiotensin converting enzyme 2	Homo sapiens	117-121
32995775-0	2020	Ambroxol Hydrochloride Inhibits the Interaction between Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein"s Receptor Binding Domain and Recombinant Human ACE2.	Ambroxol hydrochloride	0-22	angiotensin converting enzyme 2	Homo sapiens	166-170
32995775-4	2020	Herein, we discovered that Ambroxol hydrochloride (AMB), and its progenitor, Bromhexine hydrochloride (BHH), both clinically approved drugs are potent effective modulators of the key interaction between the receptor binding domain (RBD) of SARS-CoV-2 spike protein and human ACE2.	Ambroxol hydrochloride	27-49	angiotensin converting enzyme 2	Homo sapiens	275-279
32995775-4	2020	Herein, we discovered that Ambroxol hydrochloride (AMB), and its progenitor, Bromhexine hydrochloride (BHH), both clinically approved drugs are potent effective modulators of the key interaction between the receptor binding domain (RBD) of SARS-CoV-2 spike protein and human ACE2.	amb	51-54	angiotensin converting enzyme 2	Homo sapiens	275-279
32995775-4	2020	Herein, we discovered that Ambroxol hydrochloride (AMB), and its progenitor, Bromhexine hydrochloride (BHH), both clinically approved drugs are potent effective modulators of the key interaction between the receptor binding domain (RBD) of SARS-CoV-2 spike protein and human ACE2.	Bromhexine	77-101	angiotensin converting enzyme 2	Homo sapiens	275-279
32995775-4	2020	Herein, we discovered that Ambroxol hydrochloride (AMB), and its progenitor, Bromhexine hydrochloride (BHH), both clinically approved drugs are potent effective modulators of the key interaction between the receptor binding domain (RBD) of SARS-CoV-2 spike protein and human ACE2.	Bromhexine	103-106	angiotensin converting enzyme 2	Homo sapiens	275-279
32915649-5	2020	Finally, molecular docking simulations were performed to study matrine-Mpro, matrine-ACE2, and matrine-RdRp interactions.	matrine	77-84	angiotensin converting enzyme 2	Homo sapiens	85-89
32933039-1	2020	BACKGROUND: In COVID-19 patients, aldosterone via angiotensin-converting enzyme-2 deregulation may be responsible for systemic and pulmonary vasoconstriction, inflammation, and oxidative organ damage.	Aldosterone	34-45	angiotensin converting enzyme 2	Homo sapiens	50-81
32914690-2	2022	The layer dependent inhibitory effect of graphene nanosheets on spike receptor-binding domain of 6LZG, complexed with host receptor i.e. angiotensin-converting enzyme 2 (ACE2) of SARS-CoV-2 was investigated through computational study.	Graphite	41-49	angiotensin converting enzyme 2	Homo sapiens	137-168
33082849-4	2020	Angiotensin converting enzyme-2 (ACE-2) mediated cellular entry of SARS-Cov2 leads to receptor shedding of ACE-2 and disrupts the renin angiotensin aldosterone axis (RAAS).	Aldosterone	148-159	angiotensin converting enzyme 2	Homo sapiens	0-31
33082849-4	2020	Angiotensin converting enzyme-2 (ACE-2) mediated cellular entry of SARS-Cov2 leads to receptor shedding of ACE-2 and disrupts the renin angiotensin aldosterone axis (RAAS).	Aldosterone	148-159	angiotensin converting enzyme 2	Homo sapiens	33-38
32914690-2	2022	The layer dependent inhibitory effect of graphene nanosheets on spike receptor-binding domain of 6LZG, complexed with host receptor i.e. angiotensin-converting enzyme 2 (ACE2) of SARS-CoV-2 was investigated through computational study.	Graphite	41-49	angiotensin converting enzyme 2	Homo sapiens	170-174
33294769-7	2020	In addition, residue Asn488Rs3367 interacted with a previously defined pocket on ACE2 composed of Tyr41, Lys353 and Asp355.	asn488rs3367	21-33	angiotensin converting enzyme 2	Homo sapiens	81-85
32753553-2	2020	By using deep mutagenesis, mutations in ACE2 that increase S binding are found across the interaction surface, in the asparagine 90-glycosylation motif and at buried sites.	Asparagine	118-128	angiotensin converting enzyme 2	Homo sapiens	40-44
33155953-9	2020	Due to its antiandrogenic effects, spironolactone can inhibit X-chromosome-related synthesis of ACE-2 receptors and activation of transmembrane serin protease 2.	Spironolactone	35-49	angiotensin converting enzyme 2	Homo sapiens	96-101
32726128-5	2020	Testosterone on the contrary enhances the levels of the two most critical molecules, angiotensin-converting enzyme 2 (ACE2) and the transmembrane protease serine-type 2 (TMPRSS2), transcriptionally and posttranslationally, thereby increasing viral load and delaying viral clearance in men as compared with women.	Testosterone	0-12	angiotensin converting enzyme 2	Homo sapiens	85-116
32887876-5	2020	A cryo-electron microscopy structure of the bound complex at 2.9 A resolution reveals that Ty1 binds to an epitope on the RBD accessible in both the "up" and "down" conformations, sterically hindering RBD-ACE2 binding.	ty1	91-94	angiotensin converting enzyme 2	Homo sapiens	205-209
32726128-5	2020	Testosterone on the contrary enhances the levels of the two most critical molecules, angiotensin-converting enzyme 2 (ACE2) and the transmembrane protease serine-type 2 (TMPRSS2), transcriptionally and posttranslationally, thereby increasing viral load and delaying viral clearance in men as compared with women.	Testosterone	0-12	angiotensin converting enzyme 2	Homo sapiens	118-122
32544563-6	2020	The virus-mediated down-regulation of ACE2 causes a burst of inflammatory cytokine release through dysregulation of the renin-angiotensin-aldosterone system (ACE/angiotensin II/AT1R axis), attenuation of Mas receptor (ACE2/MasR axis), increased activation of [des-Arg9]-bradykinin (ACE2/bradykinin B1R/DABK axis), and activation of the complement system including C5a and C5b-9 components.	Aldosterone	138-149	angiotensin converting enzyme 2	Homo sapiens	38-42
32544563-6	2020	The virus-mediated down-regulation of ACE2 causes a burst of inflammatory cytokine release through dysregulation of the renin-angiotensin-aldosterone system (ACE/angiotensin II/AT1R axis), attenuation of Mas receptor (ACE2/MasR axis), increased activation of [des-Arg9]-bradykinin (ACE2/bradykinin B1R/DABK axis), and activation of the complement system including C5a and C5b-9 components.	des-arg9	260-268	angiotensin converting enzyme 2	Homo sapiens	38-42
32601125-4	2020	ACE2 could be implicated in the production of reactive oxygen species (ROS) caused by endothelial dysfunction due to viral damage.	Reactive Oxygen Species	46-69	angiotensin converting enzyme 2	Homo sapiens	0-4
32601125-4	2020	ACE2 could be implicated in the production of reactive oxygen species (ROS) caused by endothelial dysfunction due to viral damage.	Reactive Oxygen Species	71-74	angiotensin converting enzyme 2	Homo sapiens	0-4
32669391-3	2020	Previously, we have shown that loss of angiotensin-I converting enzyme 2 (ACE2) promotes the ACE/angiotensin-II (Ang-II)/angiotensin type 1 receptor (AT1R) axis, a deleterious arm of RAS, unleashing its detrimental effects in diabetes.	N-(2-acetamido)-2-aminoethanesulfonic acid	74-77	angiotensin converting enzyme 2	Homo sapiens	39-72
32871846-5	2020	RESULTS: Ivermectin docked in the region of leucine 91 of the spike and histidine 378 of the ACE2 receptor.	Histidine	72-81	angiotensin converting enzyme 2	Homo sapiens	93-97
32669391-3	2020	Previously, we have shown that loss of angiotensin-I converting enzyme 2 (ACE2) promotes the ACE/angiotensin-II (Ang-II)/angiotensin type 1 receptor (AT1R) axis, a deleterious arm of RAS, unleashing its detrimental effects in diabetes.	ang-ii	113-119	angiotensin converting enzyme 2	Homo sapiens	39-72
32669391-3	2020	Previously, we have shown that loss of angiotensin-I converting enzyme 2 (ACE2) promotes the ACE/angiotensin-II (Ang-II)/angiotensin type 1 receptor (AT1R) axis, a deleterious arm of RAS, unleashing its detrimental effects in diabetes.	ang-ii	113-119	angiotensin converting enzyme 2	Homo sapiens	74-78
32189428-5	2020	We predict that these individuals are "primed" to be at higher risk because nicotine can directly impact the putative receptor for the virus (ACE2) and lead to deleterious signaling in lung epithelial cells.	Nicotine	76-84	angiotensin converting enzyme 2	Homo sapiens	142-146
32672061-3	2020	In this review, we summarize peptide and peptide-based therapeutics that target one main entry pathway of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which involves the host angiotensin-converting enzyme-2 (ACE2) receptor and viral spike (S) protein interaction.	Peptides	29-36	angiotensin converting enzyme 2	Homo sapiens	192-223
32672061-3	2020	In this review, we summarize peptide and peptide-based therapeutics that target one main entry pathway of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which involves the host angiotensin-converting enzyme-2 (ACE2) receptor and viral spike (S) protein interaction.	Peptides	29-36	angiotensin converting enzyme 2	Homo sapiens	225-229
32672061-3	2020	In this review, we summarize peptide and peptide-based therapeutics that target one main entry pathway of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which involves the host angiotensin-converting enzyme-2 (ACE2) receptor and viral spike (S) protein interaction.	Peptides	41-48	angiotensin converting enzyme 2	Homo sapiens	192-223
32672061-3	2020	In this review, we summarize peptide and peptide-based therapeutics that target one main entry pathway of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which involves the host angiotensin-converting enzyme-2 (ACE2) receptor and viral spike (S) protein interaction.	Peptides	41-48	angiotensin converting enzyme 2	Homo sapiens	225-229
32783758-7	2020	It illustrates new analyses of the structure of ACE2 that provides better understanding of its actions particularly in lung and gut, shedding of ACE2 by ADAM17 (a disintegrin and metallopeptidase domain 17 protein), and role of TMPRSS2 (transmembrane serine proteases 2) in severe acute respiratory syndrome coronavirus-2 entry into host cells.	Serine	251-257	angiotensin converting enzyme 2	Homo sapiens	48-52
32738306-7	2020	The findings showed AZM affinity scores (DeltaG) with strong interactions with ACE2, CTSL, Mpro and RBD.	Azithromycin	20-23	angiotensin converting enzyme 2	Homo sapiens	79-83
32738306-8	2020	CQ affinity scores showed three low-energy results (less negative) with ACE2, CTSL and RBD, and a firm bond score with Mpro.	Chloroquine	0-2	angiotensin converting enzyme 2	Homo sapiens	72-76
32738306-9	2020	For HCQ, two results (ACE2 and Mpro) were firmly bound to the receptors, however CTSL and RBD showed low interaction energies.	Hydroxychloroquine	4-7	angiotensin converting enzyme 2	Homo sapiens	22-26
32738306-10	2020	The differences in better interactions and affinity between HCQ and CQ with ACE2 and Mpro were probably due to structural differences between the drugs.	Hydroxychloroquine	60-63	angiotensin converting enzyme 2	Homo sapiens	76-80
32738306-10	2020	The differences in better interactions and affinity between HCQ and CQ with ACE2 and Mpro were probably due to structural differences between the drugs.	Chloroquine	61-63	angiotensin converting enzyme 2	Homo sapiens	76-80
32654557-2	2020	There have been concerns on whether alterations of ACE2 expression by renin-angiotensin-aldosterone system (RAAS) inhibitors would contribute to the infectivity and severity of coronavirus disease 2019 (COVID-19).	Aldosterone	88-99	angiotensin converting enzyme 2	Homo sapiens	51-55
32645632-2	2020	Recently, a cell surface protein, known as angiotensin-converting enzyme II (ACE2), has been identified to be involved in receptor-mediated endocytosis for SARS-CoV-2 entry to the cells.	angiotensin-converting enzyme ii	43-75	angiotensin converting enzyme 2	Homo sapiens	77-81
32645632-8	2020	Baricitinib is expected to interrupt the passage and intracellular assembly of SARS-CoV-2 into the target cells mediated by ACE2 receptor, and treat cytokine storm caused by COVID-19.	baricitinib	0-11	angiotensin converting enzyme 2	Homo sapiens	124-128
32456846-6	2020	RESULTS: COVID-19 may enhance complications in individuals with diabetes through an imbalance in angiotension-converting enzyme 2 (ACE2) activation pathways leading to an inflammatory response.	angiotension	97-109	angiotensin converting enzyme 2	Homo sapiens	131-135
32335456-3	2020	The pathogenic infectivity of the virus requires the S1 subunit of the spike (S) protein to bind the host cell receptor, angiontensin converting enzyme (ACE2).	angiontensin	121-133	angiotensin converting enzyme 2	Homo sapiens	153-157
32574379-5	2020	These findings are applicable to a parallel strategy for the generation of polysaccharides similar to those present in the receptor-binding domain of CoViD-19, which might inhibit viral adhesion to its receptor, the angiotensin-converting enzyme-2 (ACE2) protein, thereby impairing cellular uptake of the virus itself.	Polysaccharides	75-90	angiotensin converting enzyme 2	Homo sapiens	216-247
32574379-5	2020	These findings are applicable to a parallel strategy for the generation of polysaccharides similar to those present in the receptor-binding domain of CoViD-19, which might inhibit viral adhesion to its receptor, the angiotensin-converting enzyme-2 (ACE2) protein, thereby impairing cellular uptake of the virus itself.	Polysaccharides	75-90	angiotensin converting enzyme 2	Homo sapiens	249-253
32904601-0	2021	Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications.	Polysaccharides	115-122	angiotensin converting enzyme 2	Homo sapiens	89-93
32825954-2	2020	The main mechanisms of virus internalization and interaction with the host are down-regulation or upregulation of the ACE2 receptor, the surface glycoprotein competition mechanism for the binding of porphyrin to iron in heme formation as well as interference with the immune system.	Iron	212-216	angiotensin converting enzyme 2	Homo sapiens	118-122
32584474-6	2020	Therefore, targeting the unbalanced RAS and ACE2 down-regulation with vitamin D in SARS-CoV-2 infection is a potential therapeutic approach to combat COVID-19 and induced ARDS.	Vitamin D	70-79	angiotensin converting enzyme 2	Homo sapiens	44-48
32865675-1	2022	We have previously shown that angiotensin-converting enzyme 2 (ACE2), an enzyme counterbalancing the deleterious effects of angiotensin type 1 receptor activation by production of vasodilatory peptides Angiotensin (Ang)-(1-9) and Ang-(1-7), is internalized and degraded in lysosomes following chronic Ang-II treatment.	Peptides	193-201	angiotensin converting enzyme 2	Homo sapiens	30-61
32865675-1	2022	We have previously shown that angiotensin-converting enzyme 2 (ACE2), an enzyme counterbalancing the deleterious effects of angiotensin type 1 receptor activation by production of vasodilatory peptides Angiotensin (Ang)-(1-9) and Ang-(1-7), is internalized and degraded in lysosomes following chronic Ang-II treatment.	Peptides	193-201	angiotensin converting enzyme 2	Homo sapiens	63-67
32402766-6	2020	The antimalarial drugs chloroquine phosphate (CQ) and hydroxychloroquine (HCQ) impair in vitro the terminal glycosylation of ACE2 without significant change of cell-surface ACE2 and, therefore, might be potent inhibitors of SARS-CoV-2 infections.	chloroquine diphosphate	23-44	angiotensin converting enzyme 2	Homo sapiens	125-129
32402766-6	2020	The antimalarial drugs chloroquine phosphate (CQ) and hydroxychloroquine (HCQ) impair in vitro the terminal glycosylation of ACE2 without significant change of cell-surface ACE2 and, therefore, might be potent inhibitors of SARS-CoV-2 infections.	chloroquine diphosphate	46-48	angiotensin converting enzyme 2	Homo sapiens	125-129
32402766-6	2020	The antimalarial drugs chloroquine phosphate (CQ) and hydroxychloroquine (HCQ) impair in vitro the terminal glycosylation of ACE2 without significant change of cell-surface ACE2 and, therefore, might be potent inhibitors of SARS-CoV-2 infections.	Hydroxychloroquine	54-72	angiotensin converting enzyme 2	Homo sapiens	125-129
32402766-6	2020	The antimalarial drugs chloroquine phosphate (CQ) and hydroxychloroquine (HCQ) impair in vitro the terminal glycosylation of ACE2 without significant change of cell-surface ACE2 and, therefore, might be potent inhibitors of SARS-CoV-2 infections.	Hydroxychloroquine	74-77	angiotensin converting enzyme 2	Homo sapiens	125-129
33081905-12	2020	The possible mechanism is that metformin could inhibit cytokine storm via suppressing interleukin-6 (IL-6) signaling, prevent the process of lung fibrosis, suppress endocytosis, thereby elevating angiotensin converting enzyme 2 (ACE2) expression.	Metformin	31-40	angiotensin converting enzyme 2	Homo sapiens	196-227
33081905-12	2020	The possible mechanism is that metformin could inhibit cytokine storm via suppressing interleukin-6 (IL-6) signaling, prevent the process of lung fibrosis, suppress endocytosis, thereby elevating angiotensin converting enzyme 2 (ACE2) expression.	Metformin	31-40	angiotensin converting enzyme 2	Homo sapiens	229-233
32904601-3	2021	All seven glycosylation sites in human angiotensin I converting enzyme 2 (hACE2) were found to be completely occupied, mainly by complex N-glycans.	n-glycans	137-146	angiotensin converting enzyme 2	Homo sapiens	39-72
32904601-3	2021	All seven glycosylation sites in human angiotensin I converting enzyme 2 (hACE2) were found to be completely occupied, mainly by complex N-glycans.	n-glycans	137-146	angiotensin converting enzyme 2	Homo sapiens	74-79
32904601-5	2021	Additional post-translational modification (PTM) was identified, including multiple methylated sites in both proteins and multiple sites with hydroxylproline in hACE2.	hydroxylproline	142-157	angiotensin converting enzyme 2	Homo sapiens	161-166
32904601-6	2021	Refined structural models of HCoV-19 S and hACE2 were built by adding N-glycan and PTMs to recently published cryogenic electron microscopy (cryo-EM) structures.	n-glycan	70-78	angiotensin converting enzyme 2	Homo sapiens	43-48
32904601-7	2021	The PTM and glycan maps of HCoV-19 S and hACE2 provide additional structural details for studying the mechanisms underlying host attachment and the immune response of HCoV-19, as well as knowledge for developing desperately needed remedies and vaccines.	Polysaccharides	12-18	angiotensin converting enzyme 2	Homo sapiens	41-46
32831104-7	2020	Of those 12 variants, we further showed that p.His378Arg could directly weaken the binding of catalytic metal atom to decrease ACE2 activity and p.Ser19Pro could distort the most important helix to the S-protein.	Metals	104-109	angiotensin converting enzyme 2	Homo sapiens	127-131
32869029-9	2020	The availability of a conceptually simple MMGB/SA-based protocol for analysis of the SARS-CoV-2 /ACE2 binding may be beneficial in light of the need to move forward fast.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	47-49	angiotensin converting enzyme 2	Homo sapiens	97-101
32678978-6	2020	Using this technique in combination with molecular modeling also allows the role of heparin in destabilizing the ACE2/RBD association to be studied, providing critical information for understanding the molecular mechanism of its interference with the virus docking to the host cell receptor.	Heparin	84-91	angiotensin converting enzyme 2	Homo sapiens	113-117
32864572-7	2020	We presume that restoration of normal functioning of renin-angiotensin system with recombinant human angiotensin-converting enzyme 2 (rhACE2), angiotensin (1-7) and angiotensin (1-9) may be an effective therapeutic measure but studies will be required to test this hypothesis and explore its possible role in treatment of COVID-19.	rhace2	134-140	angiotensin converting enzyme 2	Homo sapiens	101-132
32678978-9	2020	The destabilizing effect of heparin is more pronounced in the case of the longer chains due to the electrostatic repulsion between the low-pI ACE2 and the heparin segments not accommodated on the RBD surface.	Heparin	28-35	angiotensin converting enzyme 2	Homo sapiens	142-146
32974340-11	2020	Further, we discovered unique signatures of genes in ACE2 + TMPRSS2 + STBs and EVTs.	stbs	70-74	angiotensin converting enzyme 2	Homo sapiens	53-57
32678978-10	2020	In addition to providing important mechanistic information on attenuation of the ACE2/RBD association by heparin, the study demonstrates the yet untapped potential of native MS coupled to gas-phase ion chemistry as a means of facilitating rational repurposing of the existing medicines for treating COVID-19.	Heparin	105-112	angiotensin converting enzyme 2	Homo sapiens	81-85
32974340-11	2020	Further, we discovered unique signatures of genes in ACE2 + TMPRSS2 + STBs and EVTs.	evts	79-83	angiotensin converting enzyme 2	Homo sapiens	53-57
32819226-4	2021	OBJECTIVE: In this aspect, our objective was to screen essential flavonoids against possible protein targets such as SARS-CoV-2 spike glycoprotein receptor binding domain (RBD-S) and host Angiotensin Converting Enzyme-2 protease domain (PD-ACE-2) using in silico molecular docking studies.	Flavonoids	65-75	angiotensin converting enzyme 2	Homo sapiens	188-219
32974340-12	2020	The ACE2 + TMPRSS2 + STBs are highly differentiated cells and express genes involving mitochondrial metabolism and glucose transport.	Glucose	115-122	angiotensin converting enzyme 2	Homo sapiens	4-8
32819226-4	2021	OBJECTIVE: In this aspect, our objective was to screen essential flavonoids against possible protein targets such as SARS-CoV-2 spike glycoprotein receptor binding domain (RBD-S) and host Angiotensin Converting Enzyme-2 protease domain (PD-ACE-2) using in silico molecular docking studies.	Flavonoids	65-75	angiotensin converting enzyme 2	Homo sapiens	240-245
32824674-4	2020	High testosterone levels could upregulate transmembrane serine protease 2 (TMPRSS2), facilitating the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into host cells via angiotensin-converting enzyme 2 (ACE2).	Testosterone	5-17	angiotensin converting enzyme 2	Homo sapiens	192-223
32819226-6	2021	The flavonoids that passed Lipinski rule were subjected to in silico analysis through molecular docking on RBD-S and PD-ACE-2 using Molegro Virtual Docker v6.0.	Flavonoids	4-14	angiotensin converting enzyme 2	Homo sapiens	120-125
32824674-4	2020	High testosterone levels could upregulate transmembrane serine protease 2 (TMPRSS2), facilitating the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into host cells via angiotensin-converting enzyme 2 (ACE2).	Testosterone	5-17	angiotensin converting enzyme 2	Homo sapiens	225-229
32819226-8	2021	In silicoanalysis reported that biochanin A and silymarin bind significantly at the active sites of RBD-Sand PD-ACE-2 with a MolDock score of -78.41and -121.28 kcal/mol respectively.	Silymarin	48-57	angiotensin converting enzyme 2	Homo sapiens	112-117
32819226-10	2021	CONCLUSION: The current outcomes created a new paradigm in understanding biochanin A and silymarin bioflavonoids as potent inhibitors of RBD-Sand PD-ACE-2 targets respectively, further work can be extended to confirm their therapeutic potential in COVID-19.	Silymarin	89-98	angiotensin converting enzyme 2	Homo sapiens	149-154
32819226-10	2021	CONCLUSION: The current outcomes created a new paradigm in understanding biochanin A and silymarin bioflavonoids as potent inhibitors of RBD-Sand PD-ACE-2 targets respectively, further work can be extended to confirm their therapeutic potential in COVID-19.	Flavonoids	99-112	angiotensin converting enzyme 2	Homo sapiens	149-154
32838195-4	2020	Firstly, AMPK mediated phosphorylation of ACE-2 by metformin as well as the drug"s alkaline properties may interrupt the natural disease progression.	Metformin	51-60	angiotensin converting enzyme 2	Homo sapiens	42-47
32807895-9	2020	Our data showed that Simeprevir and Lumacaftor bind the receptor-binding domain of the Spike protein with high affinity and prevent ACE2 interaction.	Simeprevir	21-31	angiotensin converting enzyme 2	Homo sapiens	132-136
32817933-5	2020	These same lipid domains recruit the SARS-CoV-2 surface receptor angiotensin converting enzyme 2 (ACE2) to an endocytic entry point and their disruption by cholesterol depletion decreases ACE2 recruitment and viral entry.	Cholesterol	156-167	angiotensin converting enzyme 2	Homo sapiens	65-96
32807895-9	2020	Our data showed that Simeprevir and Lumacaftor bind the receptor-binding domain of the Spike protein with high affinity and prevent ACE2 interaction.	lumacaftor	36-46	angiotensin converting enzyme 2	Homo sapiens	132-136
32817933-5	2020	These same lipid domains recruit the SARS-CoV-2 surface receptor angiotensin converting enzyme 2 (ACE2) to an endocytic entry point and their disruption by cholesterol depletion decreases ACE2 recruitment and viral entry.	Cholesterol	156-167	angiotensin converting enzyme 2	Homo sapiens	188-192
32817933-13	2020	HCQ blocked both GM1 and PIP 2 domains ability to attract and cluster ACE2.	Hydroxychloroquine	0-3	angiotensin converting enzyme 2	Homo sapiens	70-74
32817933-13	2020	HCQ blocked both GM1 and PIP 2 domains ability to attract and cluster ACE2.	G(M1) Ganglioside	17-20	angiotensin converting enzyme 2	Homo sapiens	70-74
32817933-20	2020	Meaning: Since lipids cluster ACE2 and facilitate viral entry, hydroxychloroquine and anesthetics appear to inhibit viral entry by disrupting the lipid clustering and ACE2 localization.	Hydroxychloroquine	63-81	angiotensin converting enzyme 2	Homo sapiens	167-171
32817951-0	2020	Discovery of Clioquinol and Analogues as Novel Inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 Infection, ACE2 and ACE2 - Spike Protein Interaction In Vitro.	Clioquinol	13-23	angiotensin converting enzyme 2	Homo sapiens	120-124
32817951-0	2020	Discovery of Clioquinol and Analogues as Novel Inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 Infection, ACE2 and ACE2 - Spike Protein Interaction In Vitro.	Clioquinol	13-23	angiotensin converting enzyme 2	Homo sapiens	129-133
32922297-3	2020	ACE2 serves as an endogenous inhibitor of inflammatory signals associated with four major regulator systems: the renin-angiotensin-aldosterone system (RAAS), the complement system, the coagulation cascade, and the kallikrein-kinin system (KKS).	Aldosterone	131-142	angiotensin converting enzyme 2	Homo sapiens	0-4
32817951-5	2020	In addition, all three compounds showed potent anti-exopeptidase activity against recombinant human angiotensin converting enzyme 2 (rhACE2) and inhibited the binding of rhACE2 with SARS-CoV-2 Spike (RBD) protein.	rhace2	133-139	angiotensin converting enzyme 2	Homo sapiens	100-131
32849666-11	2020	Angiotensin-Converting-Enzyme (ACE) 2 displays lung protective effects: it inactivates DABK and converts Angiotensin II (Ang II) into Angiotensin-(1-7) and Angiotensin I into Angiotensin-(1-9).	dabk	87-91	angiotensin converting enzyme 2	Homo sapiens	0-37
32784543-6	2020	Of specific interest are chloroquine/hydroxychloroquine"s ability to inhibit SARS-CoV infection by impairing ACE2, the SARS-CoV2 entry point, through terminal glycosylation via effects on TGN/post-Golgi pH homeostasis.	Chloroquine	25-36	angiotensin converting enzyme 2	Homo sapiens	109-113
32818210-5	2020	Elovanoid (ELV)-N32 or Resolvin D6-isomer (RvD6i), among the lipid mediators studied, consistently decreased the expression of the ACE2 receptor, furin, and integrins in damaged corneas or IFNgamma stimulated human corneal epithelial cells (HCEC).	elvitegravir	11-14	angiotensin converting enzyme 2	Homo sapiens	131-135
32848769-7	2020	The renin-angiotensin-aldosterone system (RAAS) component ACE2 and DPP4 are proteins dysregulated in diabetes.	Aldosterone	22-33	angiotensin converting enzyme 2	Homo sapiens	58-62
32818210-0	2020	Elovanoid-N32 or RvD6-isomer decrease ACE2 and binding of S protein RBD after injury or INFgamma in the eye.	Elovanoid N32	0-13	angiotensin converting enzyme 2	Homo sapiens	38-42
32818210-5	2020	Elovanoid (ELV)-N32 or Resolvin D6-isomer (RvD6i), among the lipid mediators studied, consistently decreased the expression of the ACE2 receptor, furin, and integrins in damaged corneas or IFNgamma stimulated human corneal epithelial cells (HCEC).	elovanoid	0-9	angiotensin converting enzyme 2	Homo sapiens	131-135
32762417-1	2021	Recent studies have pointed the role of angiotensin-converting enzyme-II (ACE2) in mediating the entry of SARS-CoV-2 to the host cell by binding to the receptor-binding domain (RBD) of viral spike protein, and successive priming by cellular proteases initiates the infection.	angiotensin-converting enzyme-ii	40-72	angiotensin converting enzyme 2	Homo sapiens	74-78
32762417-3	2021	To understand, how mutations in the conserved residues of RBD affect the molecular interaction with ACE2, we generated five alanine mutants i.e. Y449A, N487A, Y489A, N501A and Y505A in the receptor binding motif (RBM) of the ACE2-RBD SARS-CoV-2 complex (PDB: 6M0J).	Alanine	124-131	angiotensin converting enzyme 2	Homo sapiens	100-104
32762417-5	2021	In silico mutational analysis revealed loss of important intermolecular hydrogen bonds and other non-bonded contacts, critical for molecular recognition of SARS-CoV-2 RBD to ACE2, which is well supported by saturation mutagenesis study of binding interface residues.	Hydrogen	72-80	angiotensin converting enzyme 2	Homo sapiens	174-178
32784543-6	2020	Of specific interest are chloroquine/hydroxychloroquine"s ability to inhibit SARS-CoV infection by impairing ACE2, the SARS-CoV2 entry point, through terminal glycosylation via effects on TGN/post-Golgi pH homeostasis.	Hydroxychloroquine	37-55	angiotensin converting enzyme 2	Homo sapiens	109-113
32784543-8	2020	We suggest that linkage between the specific gene defects identified in GS and BS and the myriad of distinctive and frequently overlapping clinical findings may be the result of aberrant glycosylation of ACE2 driven by altered TGN/endosome system acidification caused by the metabolic alkalosis brought about by these salt-losing tubulopathies in addition to their altered intracellular calcium signaling due to a blunted second messenger induced intracellular calcium release that is, in turn, amplified by the RAS system.	Calcium	387-394	angiotensin converting enzyme 2	Homo sapiens	204-208
32784543-8	2020	We suggest that linkage between the specific gene defects identified in GS and BS and the myriad of distinctive and frequently overlapping clinical findings may be the result of aberrant glycosylation of ACE2 driven by altered TGN/endosome system acidification caused by the metabolic alkalosis brought about by these salt-losing tubulopathies in addition to their altered intracellular calcium signaling due to a blunted second messenger induced intracellular calcium release that is, in turn, amplified by the RAS system.	Calcium	461-468	angiotensin converting enzyme 2	Homo sapiens	204-208
32756606-3	2020	We see that some ACE2 glycans interact with the S fragments, and glycans are influencing the conformation of the ACE2 receptor.	Polysaccharides	22-29	angiotensin converting enzyme 2	Homo sapiens	17-21
32643603-7	2020	Ad5-hACE2-transduced mice enabled rapid assessments of a vaccine candidate, of human convalescent plasma, and of two antiviral therapies (poly I:C and remdesivir).	Poly I-C	138-146	angiotensin converting enzyme 2	Homo sapiens	4-9
32643603-7	2020	Ad5-hACE2-transduced mice enabled rapid assessments of a vaccine candidate, of human convalescent plasma, and of two antiviral therapies (poly I:C and remdesivir).	remdesivir	151-161	angiotensin converting enzyme 2	Homo sapiens	4-9
32793900-6	2020	Computational alanine scanning mutagenesis was performed to predict changes in Gibbs free energy that are associated with mutating residues at the positive control (PMI/MDM2) or SARS RBD/ACE2 binding interface to alanine.	Alanine	14-21	angiotensin converting enzyme 2	Homo sapiens	187-191
32793900-6	2020	Computational alanine scanning mutagenesis was performed to predict changes in Gibbs free energy that are associated with mutating residues at the positive control (PMI/MDM2) or SARS RBD/ACE2 binding interface to alanine.	Alanine	213-220	angiotensin converting enzyme 2	Homo sapiens	187-191
32752951-4	2021	In this study, molecular docking and reactivity were applied for eighteen drugs, which are similar in structure to chloroquine and hydroxychloroquine, the potential inhibitors to angiotensin-converting enzyme (ACE2).	Chloroquine	115-126	angiotensin converting enzyme 2	Homo sapiens	210-214
32752951-4	2021	In this study, molecular docking and reactivity were applied for eighteen drugs, which are similar in structure to chloroquine and hydroxychloroquine, the potential inhibitors to angiotensin-converting enzyme (ACE2).	Hydroxychloroquine	131-149	angiotensin converting enzyme 2	Homo sapiens	210-214
32752951-7	2021	The results obtained from this study showed that Ramipril, Delapril and Lisinopril could bind with ACE2 receptor and [SARS-CoV-2/ACE2] complex better than chloroquine and hydroxychloroquine.	Ramipril	49-57	angiotensin converting enzyme 2	Homo sapiens	99-103
32752951-7	2021	The results obtained from this study showed that Ramipril, Delapril and Lisinopril could bind with ACE2 receptor and [SARS-CoV-2/ACE2] complex better than chloroquine and hydroxychloroquine.	delapril	59-67	angiotensin converting enzyme 2	Homo sapiens	99-103
32752951-7	2021	The results obtained from this study showed that Ramipril, Delapril and Lisinopril could bind with ACE2 receptor and [SARS-CoV-2/ACE2] complex better than chloroquine and hydroxychloroquine.	Lisinopril	72-82	angiotensin converting enzyme 2	Homo sapiens	99-103
32756606-3	2020	We see that some ACE2 glycans interact with the S fragments, and glycans are influencing the conformation of the ACE2 receptor.	Polysaccharides	22-29	angiotensin converting enzyme 2	Homo sapiens	113-117
32515982-6	2020	It is suggested that H2S may block SARS-CoV-2 entry into host cells by interfering with ACE2 and TMPRSS2, inhibit SARS-CoV-2 replication by attenuating virus assembly/release, and protect SARS-CoV-2-induced lung damage by suppressing immune response and inflammation development.	Deuterium	21-24	angiotensin converting enzyme 2	Homo sapiens	88-92
32793908-4	2020	We show MEK inhibitors (MEKi) VS-6766, trametinib and selumetinib reduce ACE2 expression in human cells.	trametinib	39-49	angiotensin converting enzyme 2	Homo sapiens	73-77
32793908-4	2020	We show MEK inhibitors (MEKi) VS-6766, trametinib and selumetinib reduce ACE2 expression in human cells.	AZD 6244	54-65	angiotensin converting enzyme 2	Homo sapiens	73-77
32793908-6	2020	In some human cells, remdesivir increases ACE2-promoter luciferase-reporter expression, ACE2 mRNA and protein, and ACE2 expression is attenuated by MEKi.	remdesivir	21-31	angiotensin converting enzyme 2	Homo sapiens	42-46
32793908-6	2020	In some human cells, remdesivir increases ACE2-promoter luciferase-reporter expression, ACE2 mRNA and protein, and ACE2 expression is attenuated by MEKi.	remdesivir	21-31	angiotensin converting enzyme 2	Homo sapiens	88-92
32793908-6	2020	In some human cells, remdesivir increases ACE2-promoter luciferase-reporter expression, ACE2 mRNA and protein, and ACE2 expression is attenuated by MEKi.	remdesivir	21-31	angiotensin converting enzyme 2	Homo sapiens	88-92
32447007-9	2020	High atmospheric NO2 may provide a second hit causing a severe form of SARS-CoV-2 in ACE-2 depleted lungs resulting in a worse outcome.	Nitrogen Dioxide	17-20	angiotensin converting enzyme 2	Homo sapiens	85-90
32493627-6	2020	The presence of glutamine, asparagine, leucine, phenylalanine and serine amino acids in SARS-CoV-2 enhances ACE2 binding.	Glutamine	16-25	angiotensin converting enzyme 2	Homo sapiens	108-112
32493627-6	2020	The presence of glutamine, asparagine, leucine, phenylalanine and serine amino acids in SARS-CoV-2 enhances ACE2 binding.	Asparagine	27-37	angiotensin converting enzyme 2	Homo sapiens	108-112
32493627-6	2020	The presence of glutamine, asparagine, leucine, phenylalanine and serine amino acids in SARS-CoV-2 enhances ACE2 binding.	Leucine	39-46	angiotensin converting enzyme 2	Homo sapiens	108-112
32493627-6	2020	The presence of glutamine, asparagine, leucine, phenylalanine and serine amino acids in SARS-CoV-2 enhances ACE2 binding.	Phenylalanine	48-61	angiotensin converting enzyme 2	Homo sapiens	108-112
32493627-6	2020	The presence of glutamine, asparagine, leucine, phenylalanine and serine amino acids in SARS-CoV-2 enhances ACE2 binding.	Serine	66-72	angiotensin converting enzyme 2	Homo sapiens	108-112
32593613-2	2020	In silico modelling has identified several natural products including quercetin as potential highly effective disruptors of the initial infection process involving binding to the interface between the SARS-CoV-2 (Covid-19) Viral Spike Protein and the epithelial cell Angiotensin Converting Enzyme-2 (ACE2) protein.	Quercetin	70-79	angiotensin converting enzyme 2	Homo sapiens	267-298
32593613-2	2020	In silico modelling has identified several natural products including quercetin as potential highly effective disruptors of the initial infection process involving binding to the interface between the SARS-CoV-2 (Covid-19) Viral Spike Protein and the epithelial cell Angiotensin Converting Enzyme-2 (ACE2) protein.	Quercetin	70-79	angiotensin converting enzyme 2	Homo sapiens	300-304
32643448-12	2020	The results of molecular docking showed that baicalein and quercetin were the top two compounds of HSBDF, which had high affinity with ACE2.	baicalein	45-54	angiotensin converting enzyme 2	Homo sapiens	135-139
32643448-12	2020	The results of molecular docking showed that baicalein and quercetin were the top two compounds of HSBDF, which had high affinity with ACE2.	Quercetin	59-68	angiotensin converting enzyme 2	Homo sapiens	135-139
32643448-12	2020	The results of molecular docking showed that baicalein and quercetin were the top two compounds of HSBDF, which had high affinity with ACE2.	hsbdf	99-104	angiotensin converting enzyme 2	Homo sapiens	135-139
32643448-13	2020	CONCLUSION: Baicalein and quercetin in HSBDF may regulate multiple signaling pathways through ACE2, which might play a therapeutic role on COVID-19.	baicalein	12-21	angiotensin converting enzyme 2	Homo sapiens	94-98
32643448-13	2020	CONCLUSION: Baicalein and quercetin in HSBDF may regulate multiple signaling pathways through ACE2, which might play a therapeutic role on COVID-19.	Quercetin	26-35	angiotensin converting enzyme 2	Homo sapiens	94-98
32421102-16	2020	The results of molecular docking virtual calculation showed that phillyrin and chlorogenic acid could stably combine with Gln325 and Gln42/Asp38 in ACE2, respectively, which hindered the combination between S- protein and ACE2.	phillyrin	65-74	angiotensin converting enzyme 2	Homo sapiens	148-152
32421102-16	2020	The results of molecular docking virtual calculation showed that phillyrin and chlorogenic acid could stably combine with Gln325 and Gln42/Asp38 in ACE2, respectively, which hindered the combination between S- protein and ACE2.	phillyrin	65-74	angiotensin converting enzyme 2	Homo sapiens	222-226
32421102-16	2020	The results of molecular docking virtual calculation showed that phillyrin and chlorogenic acid could stably combine with Gln325 and Gln42/Asp38 in ACE2, respectively, which hindered the combination between S- protein and ACE2.	Chlorogenic Acid	79-95	angiotensin converting enzyme 2	Homo sapiens	148-152
32421102-16	2020	The results of molecular docking virtual calculation showed that phillyrin and chlorogenic acid could stably combine with Gln325 and Gln42/Asp38 in ACE2, respectively, which hindered the combination between S- protein and ACE2.	Chlorogenic Acid	79-95	angiotensin converting enzyme 2	Homo sapiens	222-226
32753148-5	2020	Upregulation of ACE2 mediates conversion of angiotensin II (vasoconstrictor) to angiotensin-(1-7) (vasodilator) and contributes to relatively low blood pressures, despite upregulation of other components of the renin-angiotensin-aldosterone system.	Aldosterone	229-240	angiotensin converting enzyme 2	Homo sapiens	16-20
32421102-17	2020	Conclusion: Phillyrin and chlorogenic acid can effectively prevent the combination of SARS-CoV-2 S-protein and ACE2 at the molecular level.	phillyrin	12-21	angiotensin converting enzyme 2	Homo sapiens	111-115
32421102-17	2020	Conclusion: Phillyrin and chlorogenic acid can effectively prevent the combination of SARS-CoV-2 S-protein and ACE2 at the molecular level.	Chlorogenic Acid	26-42	angiotensin converting enzyme 2	Homo sapiens	111-115
32454512-6	2020	We also performed structural studies, which revealed that CB6 recognizes an epitope that overlaps with angiotensin-converting enzyme 2 (ACE2)-binding sites in the SARS-CoV-2 receptor-binding domain, and thereby interferes with virus-receptor interactions by both steric hindrance and direct competition for interface residues.	cucurbit(6)uril	58-61	angiotensin converting enzyme 2	Homo sapiens	103-134
32454512-6	2020	We also performed structural studies, which revealed that CB6 recognizes an epitope that overlaps with angiotensin-converting enzyme 2 (ACE2)-binding sites in the SARS-CoV-2 receptor-binding domain, and thereby interferes with virus-receptor interactions by both steric hindrance and direct competition for interface residues.	cucurbit(6)uril	58-61	angiotensin converting enzyme 2	Homo sapiens	136-140
32756181-7	2020	Serum 8-OHdG level was correlated with serum ACE2, Ang(1-7) expression.	8-ohdg	6-12	angiotensin converting enzyme 2	Homo sapiens	45-49
32766576-8	2020	SMD results indicate that CoV-2 RBD interacts with the N-linked glycan on Asn90 of ACE2.	n-linked glycan	55-70	angiotensin converting enzyme 2	Homo sapiens	83-87
32766576-12	2020	After the removal of N-linked glycans on ACE2, its mechanical binding strength with CoV-2 RBD decreases to a similar level of the CoV-1 RBD-ACE2 interaction.	n-linked glycans	21-37	angiotensin converting enzyme 2	Homo sapiens	41-45
32766576-12	2020	After the removal of N-linked glycans on ACE2, its mechanical binding strength with CoV-2 RBD decreases to a similar level of the CoV-1 RBD-ACE2 interaction.	n-linked glycans	21-37	angiotensin converting enzyme 2	Homo sapiens	140-144
32756181-9	2020	Multiple-regression analysis eGFR was predicted by ACE, Hcy, eGSH-Px, and also can be predicted by ACE2, Ang(1-7), Hcy in CT subgroup.The ACE2/Ang(1-7)/Mas axis is associated with OS, and both them were associated with eGFR in the progression of CKD.	Homocysteine	56-59	angiotensin converting enzyme 2	Homo sapiens	138-142
32722164-9	2020	Therefore, this hypothesis paper describes the use of flavonoid supplements combined with vitamin D3 to activate Nrf2, which may be a potential target to prevent and/or decrease SARS-CoV-2 infection severity, reducing oxidative stress and inflammation, enhancing innate immunity, and downregulating ACE2 receptors.	Flavonoids	54-63	angiotensin converting enzyme 2	Homo sapiens	299-303
32756181-9	2020	Multiple-regression analysis eGFR was predicted by ACE, Hcy, eGSH-Px, and also can be predicted by ACE2, Ang(1-7), Hcy in CT subgroup.The ACE2/Ang(1-7)/Mas axis is associated with OS, and both them were associated with eGFR in the progression of CKD.	egsh-px	61-68	angiotensin converting enzyme 2	Homo sapiens	138-142
32756181-9	2020	Multiple-regression analysis eGFR was predicted by ACE, Hcy, eGSH-Px, and also can be predicted by ACE2, Ang(1-7), Hcy in CT subgroup.The ACE2/Ang(1-7)/Mas axis is associated with OS, and both them were associated with eGFR in the progression of CKD.	Homocysteine	115-118	angiotensin converting enzyme 2	Homo sapiens	138-142
32818905-3	2020	ACE2 regulates the protective arm of the renin-angiotensin-aldosterone system (RAAS) that endows anti-hypertensive and anti-inflammatory effects in the cardiovascular and pulmonary systems.	Aldosterone	59-70	angiotensin converting enzyme 2	Homo sapiens	0-4
32818905-6	2020	Metformin is a widely available anti-diabetic agent that has an excellent safety profile, and clinical and preclinical data suggest metformin may offer cardiopulmonary protection in COVID-19 via enhanced ACE2 expression.	Metformin	0-9	angiotensin converting enzyme 2	Homo sapiens	204-208
32818905-6	2020	Metformin is a widely available anti-diabetic agent that has an excellent safety profile, and clinical and preclinical data suggest metformin may offer cardiopulmonary protection in COVID-19 via enhanced ACE2 expression.	Metformin	132-141	angiotensin converting enzyme 2	Homo sapiens	204-208
32922174-9	2020	In addition, melatonin is an inhibitor of calmodulin, an essential intracellular component to maintain angiotensin-converting enzyme 2 (ACE-2) on the cell surface.	Melatonin	13-22	angiotensin converting enzyme 2	Homo sapiens	103-134
32922174-9	2020	In addition, melatonin is an inhibitor of calmodulin, an essential intracellular component to maintain angiotensin-converting enzyme 2 (ACE-2) on the cell surface.	Melatonin	13-22	angiotensin converting enzyme 2	Homo sapiens	136-141
32922174-12	2020	Consequently, melatonin can have response potential in early stages for its possible effects on ACE-2 and Mpro, although it is also promising in more severe stages of the disease for its action against hyper-inflammation.	Melatonin	14-23	angiotensin converting enzyme 2	Homo sapiens	96-101
32743578-4	2020	Our results highlight roles for glycans in sterically masking polypeptide epitopes and directly modulating Spike-ACE2 interactions.	Polysaccharides	32-39	angiotensin converting enzyme 2	Homo sapiens	113-117
32733785-6	2020	The level of hACE2 was significantly enhanced in hearts and kidneys of the Dox+dTg group compared to that in Vehicle+dTg mice although consistent levels of mouse ACE2 (mACE2) remained in the same tissues.	Doxycycline	75-78	angiotensin converting enzyme 2	Homo sapiens	13-18
32733785-6	2020	The level of hACE2 was significantly enhanced in hearts and kidneys of the Dox+dTg group compared to that in Vehicle+dTg mice although consistent levels of mouse ACE2 (mACE2) remained in the same tissues.	1-(4-azido-2-methylphenyl)-3-(2-methylphenyl)guanidine	79-82	angiotensin converting enzyme 2	Homo sapiens	13-18
32733785-6	2020	The level of hACE2 was significantly enhanced in hearts and kidneys of the Dox+dTg group compared to that in Vehicle+dTg mice although consistent levels of mouse ACE2 (mACE2) remained in the same tissues.	1-(4-azido-2-methylphenyl)-3-(2-methylphenyl)guanidine	117-120	angiotensin converting enzyme 2	Homo sapiens	13-18
32722164-9	2020	Therefore, this hypothesis paper describes the use of flavonoid supplements combined with vitamin D3 to activate Nrf2, which may be a potential target to prevent and/or decrease SARS-CoV-2 infection severity, reducing oxidative stress and inflammation, enhancing innate immunity, and downregulating ACE2 receptors.	Cholecalciferol	90-100	angiotensin converting enzyme 2	Homo sapiens	299-303
32664879-9	2020	We further discussed that polymorphisms in ACE2 or TMPRSS2 could guide effective treatments (i.e., hydroxychloroquine and camostat) for COVID-19.	Hydroxychloroquine	99-117	angiotensin converting enzyme 2	Homo sapiens	43-47
32793181-8	2020	The result shows rilapladib is the only quinoline that can interrupt the Spike-RBD-ACE2 complex.	rilapladib	17-27	angiotensin converting enzyme 2	Homo sapiens	83-87
32793181-8	2020	The result shows rilapladib is the only quinoline that can interrupt the Spike-RBD-ACE2 complex.	quinoline	40-49	angiotensin converting enzyme 2	Homo sapiens	83-87
32696720-3	2021	We also unveil how hydroxychloroquine can interfere in the prevention of Lys353 in hACE2 from interacting with the corresponding binding hotspot present on the Spike protein.	Hydroxychloroquine	19-37	angiotensin converting enzyme 2	Homo sapiens	83-88
32698689-7	2021	Further, our molecular dynamics (MD) simulation and energy landscape studies with fisetin, quercetin, and kamferol revealed that these molecules bind with the hACE2-S complex with low binding free energy.	fisetin	82-89	angiotensin converting enzyme 2	Homo sapiens	159-164
32698689-7	2021	Further, our molecular dynamics (MD) simulation and energy landscape studies with fisetin, quercetin, and kamferol revealed that these molecules bind with the hACE2-S complex with low binding free energy.	Quercetin	91-100	angiotensin converting enzyme 2	Homo sapiens	159-164
32698689-7	2021	Further, our molecular dynamics (MD) simulation and energy landscape studies with fisetin, quercetin, and kamferol revealed that these molecules bind with the hACE2-S complex with low binding free energy.	kamferol	106-114	angiotensin converting enzyme 2	Homo sapiens	159-164
32470515-1	2020	BACKGROUND: Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory-syndrome coronavirus-2 that interfaces with the renin-angiotensin-aldosterone system (RAAS) through angiotensin-converting enzyme 2.	Aldosterone	152-163	angiotensin converting enzyme 2	Homo sapiens	186-217
32684109-5	2021	Thus, we systematically applied the computational techniques to identify the plausible inhibitor from a chosen set of well characterized diaryl pyrimidine analogues which may disrupt interfacial interaction of spike glycoprotein (S) at the surface of hACE2.	pyrimidine	144-154	angiotensin converting enzyme 2	Homo sapiens	251-256
32684109-7	2021	Thus, pyrimidine derivative AP-NP may be explored as an effective inhibitor for hACE2-S complex.	pyrimidine	6-16	angiotensin converting enzyme 2	Homo sapiens	80-85
32684109-7	2021	Thus, pyrimidine derivative AP-NP may be explored as an effective inhibitor for hACE2-S complex.	ap-np	28-33	angiotensin converting enzyme 2	Homo sapiens	80-85
32404529-6	2020	Some ACE2 proteins even tolerate the loss or acquisition of N-glycosylation sites located near the S interface.	Nitrogen	60-61	angiotensin converting enzyme 2	Homo sapiens	5-9
32685191-6	2020	There are many common compounds that can increase the expression of the ACE2 receptor including Vitamin C, Metformin, Resveratrol, Vitamin B3 and Vitamin D.	Ascorbic Acid	96-105	angiotensin converting enzyme 2	Homo sapiens	72-76
32685191-6	2020	There are many common compounds that can increase the expression of the ACE2 receptor including Vitamin C, Metformin, Resveratrol, Vitamin B3 and Vitamin D.	Metformin	107-116	angiotensin converting enzyme 2	Homo sapiens	72-76
32685191-6	2020	There are many common compounds that can increase the expression of the ACE2 receptor including Vitamin C, Metformin, Resveratrol, Vitamin B3 and Vitamin D.	Resveratrol	118-129	angiotensin converting enzyme 2	Homo sapiens	72-76
32685191-6	2020	There are many common compounds that can increase the expression of the ACE2 receptor including Vitamin C, Metformin, Resveratrol, Vitamin B3 and Vitamin D.	Niacinamide	131-141	angiotensin converting enzyme 2	Homo sapiens	72-76
32699847-3	2020	Here we use murine leukemia viruses pseudotyped with Spike from SARS-CoV or SARS-CoV-2 to demonstrate that ACE2-mediated coronavirus entry can be mitigated by heparin, a heparan sulfate-related glycan, or by genetic ablation of biosynthetic enzymes for the cell surface heparan sulfate proteoglycans (HSPGs).	Heparin	159-166	angiotensin converting enzyme 2	Homo sapiens	107-111
32699847-3	2020	Here we use murine leukemia viruses pseudotyped with Spike from SARS-CoV or SARS-CoV-2 to demonstrate that ACE2-mediated coronavirus entry can be mitigated by heparin, a heparan sulfate-related glycan, or by genetic ablation of biosynthetic enzymes for the cell surface heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	170-185	angiotensin converting enzyme 2	Homo sapiens	107-111
32699847-3	2020	Here we use murine leukemia viruses pseudotyped with Spike from SARS-CoV or SARS-CoV-2 to demonstrate that ACE2-mediated coronavirus entry can be mitigated by heparin, a heparan sulfate-related glycan, or by genetic ablation of biosynthetic enzymes for the cell surface heparan sulfate proteoglycans (HSPGs).	Polysaccharides	194-200	angiotensin converting enzyme 2	Homo sapiens	107-111
32699847-3	2020	Here we use murine leukemia viruses pseudotyped with Spike from SARS-CoV or SARS-CoV-2 to demonstrate that ACE2-mediated coronavirus entry can be mitigated by heparin, a heparan sulfate-related glycan, or by genetic ablation of biosynthetic enzymes for the cell surface heparan sulfate proteoglycans (HSPGs).	Heparitin Sulfate	270-285	angiotensin converting enzyme 2	Homo sapiens	107-111
32699853-2	2020	Docking studies suggest a putative heparin/heparan sulfate-binding site adjacent to the domain that binds to ACE2.	Heparin	35-42	angiotensin converting enzyme 2	Homo sapiens	109-113
32699853-2	2020	Docking studies suggest a putative heparin/heparan sulfate-binding site adjacent to the domain that binds to ACE2.	Heparitin Sulfate	43-58	angiotensin converting enzyme 2	Homo sapiens	109-113
32699853-3	2020	In vitro, binding of ACE2 and heparin to spike protein ectodomains occurs independently and a ternary complex can be generated using heparin as a template.	Heparin	133-140	angiotensin converting enzyme 2	Homo sapiens	21-25
32676578-3	2020	Here, we develop a computational strategy to adaptively evolve peptides that could selectively inhibit mutating S protein receptor binding domains (RBDs) of different SARS-CoV-2 viral strains from binding to their human host receptor, angiotensin-converting enzyme 2 (ACE2).	Peptides	63-71	angiotensin converting enzyme 2	Homo sapiens	235-266
32676578-3	2020	Here, we develop a computational strategy to adaptively evolve peptides that could selectively inhibit mutating S protein receptor binding domains (RBDs) of different SARS-CoV-2 viral strains from binding to their human host receptor, angiotensin-converting enzyme 2 (ACE2).	Peptides	63-71	angiotensin converting enzyme 2	Homo sapiens	268-272
32633718-4	2020	Bradykinin is a potent part of the vasopressor system that induces hypotension and vasodilation and is degraded by ACE and enhanced by the angiotensin1-9 produced by ACE2.	angiotensin1-9	139-153	angiotensin converting enzyme 2	Homo sapiens	166-170
32760213-8	2020	GSEA showed that various metabolic and immune-related pathways were significantly associated with ACE2 expression across multiple cancer types.	gsea	0-4	angiotensin converting enzyme 2	Homo sapiens	98-102
32714335-3	2020	Chloroquine appears to inhibit in vitro SARS virus" replication and to interfere with SARS-CoV2 receptor (ACE2).	Chloroquine	0-11	angiotensin converting enzyme 2	Homo sapiens	106-110
32305506-6	2020	We decided to use the analogy of a play and speculate about the possible impact in this tragedy of 1) air pollution via the interference of nitrogen dioxide on ACE2 expression; 2) the dual role of nicotine; 3) the hypothetical involvement of ACE2 polymorphisms, the relationships of which with ethnic factors and susceptibility to cardiovascular disease seems intriguing; 4) the impact on the severity of infection of hypertension and related medications acting on the renin/angiotensin system, and, finally, 5) the possible helpful role of chloroquine, thanks to its capacity of modifying ACE2 affinity to the viral spike protein by altering glycosylation.	Nitrogen	140-148	angiotensin converting enzyme 2	Homo sapiens	160-164
32446267-3	2020	As the angiotensin-converting enzyme 2 (ACE2) facilitates the entry of coronaviruses into target cells, there have been hypotheses that preexisting use of renin-angiotensin-aldosterone system (RAAS) inhibitors may increase the risk of developing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.	Aldosterone	173-184	angiotensin converting enzyme 2	Homo sapiens	40-44
32409501-8	2020	Although not only ACE inhibitors and angiotensin 2 receptor blockers but also SGLT2 inhibitors, GLP-1 receptor agonists, pioglitazone, and probably insulin seem to increase the number of ACE2 receptors on the cells utilized by SARS-CoV-2 for penetration, no evidence presently exists that shows this might be harmful in terms of acquiring or worsening COVID-19.	Pioglitazone	121-133	angiotensin converting enzyme 2	Homo sapiens	187-191
32319538-6	2020	Indirect evidence also indicates that Zn2+ may decrease the activity of angiotensin-converting enzyme 2 (ACE2), known to be the receptor for SARS-CoV-2.	Zinc	38-42	angiotensin converting enzyme 2	Homo sapiens	72-103
32319538-6	2020	Indirect evidence also indicates that Zn2+ may decrease the activity of angiotensin-converting enzyme 2 (ACE2), known to be the receptor for SARS-CoV-2.	Zinc	38-42	angiotensin converting enzyme 2	Homo sapiens	105-109
32533197-4	2020	The pathophysiology of COVID-19 associated AKI could be related to unspecific mechanisms but also to COVID-specific mechanisms such as direct cellular injury resulting from viral entry through the receptor (ACE2) which is highly expressed in the kidney, an imbalanced renin-angotensin-aldosteron system, pro-inflammatory cytokines elicited by the viral infection and thrombotic events.	angotensin	274-284	angiotensin converting enzyme 2	Homo sapiens	207-211
32533197-4	2020	The pathophysiology of COVID-19 associated AKI could be related to unspecific mechanisms but also to COVID-specific mechanisms such as direct cellular injury resulting from viral entry through the receptor (ACE2) which is highly expressed in the kidney, an imbalanced renin-angotensin-aldosteron system, pro-inflammatory cytokines elicited by the viral infection and thrombotic events.	aldosteron	285-295	angiotensin converting enzyme 2	Homo sapiens	207-211
32708205-1	2020	BACKGROUND: The new coronavirus SARS-CoV-2, responsible for the Covid-19 pandemic, uses the angiotensin converting enzyme type 2 (ACE2), a physiological inhibitor of the renin angiotensin aldosterone system (RAAS), as a cellular receptor to infect cells.	Aldosterone	188-199	angiotensin converting enzyme 2	Homo sapiens	130-134
32677545-4	2021	Molecular docking studies showed that hydroxychloroquine and chloroquine do not interact with SARS-CoV-2 proteins, but bind to the amino acids ASP350, ASP382, ALA348, PHE40 and PHE390 on the ACE2 allosteric site rather than the ACE2 active site.	Hydroxychloroquine	38-56	angiotensin converting enzyme 2	Homo sapiens	191-195
32677545-4	2021	Molecular docking studies showed that hydroxychloroquine and chloroquine do not interact with SARS-CoV-2 proteins, but bind to the amino acids ASP350, ASP382, ALA348, PHE40 and PHE390 on the ACE2 allosteric site rather than the ACE2 active site.	Hydroxychloroquine	38-56	angiotensin converting enzyme 2	Homo sapiens	228-232
32677545-4	2021	Molecular docking studies showed that hydroxychloroquine and chloroquine do not interact with SARS-CoV-2 proteins, but bind to the amino acids ASP350, ASP382, ALA348, PHE40 and PHE390 on the ACE2 allosteric site rather than the ACE2 active site.	Chloroquine	45-56	angiotensin converting enzyme 2	Homo sapiens	191-195
32677545-4	2021	Molecular docking studies showed that hydroxychloroquine and chloroquine do not interact with SARS-CoV-2 proteins, but bind to the amino acids ASP350, ASP382, ALA348, PHE40 and PHE390 on the ACE2 allosteric site rather than the ACE2 active site.	Chloroquine	45-56	angiotensin converting enzyme 2	Homo sapiens	228-232
32677545-5	2021	Our results showed that neither hydroxychloroquine and chloroquine bind to the active site of ACE2.	Hydroxychloroquine	32-50	angiotensin converting enzyme 2	Homo sapiens	94-98
32685191-6	2020	There are many common compounds that can increase the expression of the ACE2 receptor including Vitamin C, Metformin, Resveratrol, Vitamin B3 and Vitamin D.	Vitamin D	146-155	angiotensin converting enzyme 2	Homo sapiens	72-76
32699853-6	2020	These findings support a model for SARS-CoV-2 infection in which viral attachment and infection involves formation of a complex between heparan sulfate and ACE2.	Heparitin Sulfate	136-151	angiotensin converting enzyme 2	Homo sapiens	156-160
32754161-7	2020	Evidently, GR 127935 hydrochloride hydrate, GNF-5, RS504393, TNP, and eptifibatide acetate were found binding to virus binding motifs of ACE2 receptor.	GR 127935 hydrochloride	11-42	angiotensin converting enzyme 2	Homo sapiens	137-141
32754161-7	2020	Evidently, GR 127935 hydrochloride hydrate, GNF-5, RS504393, TNP, and eptifibatide acetate were found binding to virus binding motifs of ACE2 receptor.	GNF-5	44-49	angiotensin converting enzyme 2	Homo sapiens	137-141
32754161-7	2020	Evidently, GR 127935 hydrochloride hydrate, GNF-5, RS504393, TNP, and eptifibatide acetate were found binding to virus binding motifs of ACE2 receptor.	Eptifibatide Acetate	70-90	angiotensin converting enzyme 2	Homo sapiens	137-141
32589459-1	2020	PURPOSE: The spike proteins of SARS-CoV-2 interact with ACE2 or basigin/CD147 receptors, regulating human-to-human transmissions of COVID-19 together with serine protease TMPRSS2.	Serine	155-161	angiotensin converting enzyme 2	Homo sapiens	56-60
32619162-7	2021	p28 interacted with all the three viral proteins and the host ACE-2 receptor by forming several electrostatic and hydrogen bonds with the S-protein, 3CLpro, and PLpro.	Hydrogen	114-122	angiotensin converting enzyme 2	Homo sapiens	62-67
32909725-4	2020	These findings are consistent with abnormally increased renal sodium reabsorption, possibly caused by increased angiotensin II activity secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced downregulation of angiotensin-converting enzyme 2 (ACE2) receptors.	Sodium	62-68	angiotensin converting enzyme 2	Homo sapiens	236-267
32909725-4	2020	These findings are consistent with abnormally increased renal sodium reabsorption, possibly caused by increased angiotensin II activity secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced downregulation of angiotensin-converting enzyme 2 (ACE2) receptors.	Sodium	62-68	angiotensin converting enzyme 2	Homo sapiens	269-273
32366740-3	2020	A concern was raised regarding the safety of ibuprofen use because of its role in increasing ACE2 levels within the Renin-Angiotensin-Aldosterone system.	Ibuprofen	45-54	angiotensin converting enzyme 2	Homo sapiens	93-97
32366740-4	2020	ACE2 is the coreceptor for the entry of SARS-CoV-2 into cells, and so, a potential increased risk of contracting COVID-19 disease and/or worsening of COVID-19 infection was feared with ibuprofen use.	Ibuprofen	185-194	angiotensin converting enzyme 2	Homo sapiens	0-4
32366740-5	2020	However, available data from limited studies show administration of recombinant ACE2 improves lung damage caused by respiratory viruses, suggesting ibuprofen use may be beneficial in COVID-19 disease.	Ibuprofen	148-157	angiotensin converting enzyme 2	Homo sapiens	80-84
32628137-2	2020	Renin-angiotensin-aldosterone-system (RAAS) inhibitors may increase the expression of angiotensin-converting enzyme 2, which is the receptor for SARSCoV-2 Spike protein.	Aldosterone	18-29	angiotensin converting enzyme 2	Homo sapiens	86-117
32277367-7	2020	Angiotensin converting enzyme 2 (ACE2) appears important for viral entry into pneumocytes; dysbalance in ACE2 as caused by ACE inhibitors or ibuprofen may predispose to severe disease.	Ibuprofen	141-150	angiotensin converting enzyme 2	Homo sapiens	105-109
32367746-2	2020	Coronavirus binding to ACE2 (angiotensin-converting enzyme 2), a crucial component of the renin-angiotensin-aldosterone system, underlies much of this concern.	Aldosterone	108-119	angiotensin converting enzyme 2	Homo sapiens	23-27
32367746-2	2020	Coronavirus binding to ACE2 (angiotensin-converting enzyme 2), a crucial component of the renin-angiotensin-aldosterone system, underlies much of this concern.	Aldosterone	108-119	angiotensin converting enzyme 2	Homo sapiens	29-60
32664879-9	2020	We further discussed that polymorphisms in ACE2 or TMPRSS2 could guide effective treatments (i.e., hydroxychloroquine and camostat) for COVID-19.	camostat	122-130	angiotensin converting enzyme 2	Homo sapiens	43-47
32457038-5	2020	SARS-CoV-2 shares extensive structural and functional conservation with SARS-CoV-1, including engagement of the same host cell receptor (angiotensin-converting enzyme 2) localized in cholesterol-rich microdomains.	Cholesterol	183-194	angiotensin converting enzyme 2	Homo sapiens	137-168
32501190-4	2020	Demographic and clinical comorbidities associated with the severity of infection suggest that possible variants known to influence the renin-angiotensin-aldosterone (RAAS) system pathway (particularly those that influence ACE2) may contribute to the heterogenous infection response.	angiotensin-aldosterone	141-164	angiotensin converting enzyme 2	Homo sapiens	222-226
32418199-3	2020	In human physiology, ACE2 is a pivotal counter-regulatory enzyme to ACE by the breakdown of angiotensin II, the central player in the renin-angiotensin-aldosterone system (RAAS) and the main substrate of ACE2.	Aldosterone	152-163	angiotensin converting enzyme 2	Homo sapiens	21-25
32418199-3	2020	In human physiology, ACE2 is a pivotal counter-regulatory enzyme to ACE by the breakdown of angiotensin II, the central player in the renin-angiotensin-aldosterone system (RAAS) and the main substrate of ACE2.	Aldosterone	152-163	angiotensin converting enzyme 2	Homo sapiens	204-208
32903321-1	2020	Background: The new coronavirus (SARS-CoV-2), which has been responsible for the recent coronavirus disease 2019 (COVID-19) pandemic, uses the cell receptor angiotensin converting enzyme-2 (ACE2) for entry and the serine protease TMPRSS2 for spike (S) protein priming.	Serine	214-220	angiotensin converting enzyme 2	Homo sapiens	190-194
32729248-6	2020	Vorinostat and isotretinoin are the top ACE2 up/downregulators, respectively, in cell lines.	Vorinostat	0-10	angiotensin converting enzyme 2	Homo sapiens	40-44
32729248-6	2020	Vorinostat and isotretinoin are the top ACE2 up/downregulators, respectively, in cell lines.	Isotretinoin	15-27	angiotensin converting enzyme 2	Homo sapiens	40-44
32729248-7	2020	Dexamethasone, a corticosteroid used in treating severe acute respiratory syndrome and COVID-19, significantly upregulates ACE2 both in vitro and in vivo.	Dexamethasone	0-13	angiotensin converting enzyme 2	Homo sapiens	123-127
32729248-8	2020	Further top ACE2 regulators in vivo or in primary cells include erlotinib and bleomycin in the lung and vancomycin, cisplatin, and probenecid in the kidney.	Erlotinib Hydrochloride	64-73	angiotensin converting enzyme 2	Homo sapiens	12-16
32729248-8	2020	Further top ACE2 regulators in vivo or in primary cells include erlotinib and bleomycin in the lung and vancomycin, cisplatin, and probenecid in the kidney.	Bleomycin	78-87	angiotensin converting enzyme 2	Homo sapiens	12-16
32729248-8	2020	Further top ACE2 regulators in vivo or in primary cells include erlotinib and bleomycin in the lung and vancomycin, cisplatin, and probenecid in the kidney.	Vancomycin	104-114	angiotensin converting enzyme 2	Homo sapiens	12-16
32729248-8	2020	Further top ACE2 regulators in vivo or in primary cells include erlotinib and bleomycin in the lung and vancomycin, cisplatin, and probenecid in the kidney.	Cisplatin	116-125	angiotensin converting enzyme 2	Homo sapiens	12-16
32729248-8	2020	Further top ACE2 regulators in vivo or in primary cells include erlotinib and bleomycin in the lung and vancomycin, cisplatin, and probenecid in the kidney.	Probenecid	131-141	angiotensin converting enzyme 2	Homo sapiens	12-16
32501190-4	2020	Demographic and clinical comorbidities associated with the severity of infection suggest that possible variants known to influence the renin-angiotensin-aldosterone (RAAS) system pathway (particularly those that influence ACE2) may contribute to the heterogenous infection response.	raas	166-170	angiotensin converting enzyme 2	Homo sapiens	222-226
32760206-7	2020	The drugs triciribine and kinetin riboside activate ACE2 expression or inhibit IL-6 production in macrophages to some extent.	triciribine	10-21	angiotensin converting enzyme 2	Homo sapiens	52-56
32364961-5	2020	We further explore the impact of underlying medical conditions and therapies including renin-angiotensin inhibitors on modulating ACE 2, which is the major SARS-CoV-2 cell entry receptor.	angiotensin inhibitors	93-115	angiotensin converting enzyme 2	Homo sapiens	130-135
32415494-1	2020	Scientists hypothesized that drugs such as ibuprofen or renin-angiotensin system (RAS) blockers could exacerbate the novel coronavirus disease COVID-19 by upregulating the angiotensin-converting enzyme 2 (ACE2), which serves as an entry receptor for the coronavirus SARS-CoV-2.	Ibuprofen	43-52	angiotensin converting enzyme 2	Homo sapiens	172-203
32415494-1	2020	Scientists hypothesized that drugs such as ibuprofen or renin-angiotensin system (RAS) blockers could exacerbate the novel coronavirus disease COVID-19 by upregulating the angiotensin-converting enzyme 2 (ACE2), which serves as an entry receptor for the coronavirus SARS-CoV-2.	Ibuprofen	43-52	angiotensin converting enzyme 2	Homo sapiens	205-209
32760206-7	2020	The drugs triciribine and kinetin riboside activate ACE2 expression or inhibit IL-6 production in macrophages to some extent.	kinetin riboside	26-42	angiotensin converting enzyme 2	Homo sapiens	52-56
32760206-9	2020	Hydrocortisone showed the strongest effect on ACE2 activation, followed by prednisolone, dexamethasone, and methylprednisolone.	Hydrocortisone	0-14	angiotensin converting enzyme 2	Homo sapiens	46-50
32552811-6	2020	Sub-chronic e-cig exposure with nicotine increased inflammatory cellular influx of macrophages and T-lymphocytes including increased pro-inflammatory cytokines in BALF and increased SARS-Cov-2 Covid-19 ACE2 receptor, whereas nAChRalpha7 KO mice show reduced inflammatory responses associated with decreased ACE2 receptor.	Nicotine	32-40	angiotensin converting enzyme 2	Homo sapiens	202-206
32656452-5	2020	The receptor-binding domain of the viral spike proteins and ACE2 have several cysteine residues.	Cysteine	78-86	angiotensin converting enzyme 2	Homo sapiens	60-64
32656452-6	2020	In this study, the role of thiol-disulfide balance on the interactions between SARS-CoV/CoV-2 spike proteins and ACE2 was investigated using molecular dynamics simulations.	Sulfhydryl Compounds	27-32	angiotensin converting enzyme 2	Homo sapiens	113-117
32656452-6	2020	In this study, the role of thiol-disulfide balance on the interactions between SARS-CoV/CoV-2 spike proteins and ACE2 was investigated using molecular dynamics simulations.	Disulfides	33-42	angiotensin converting enzyme 2	Homo sapiens	113-117
32656452-7	2020	The study revealed that the binding affinity was significantly impaired when all of the disulfide bonds of both ACE2 and SARS-CoV/CoV-2 spike proteins were reduced to thiol groups.	Disulfides	88-97	angiotensin converting enzyme 2	Homo sapiens	112-116
32656452-7	2020	The study revealed that the binding affinity was significantly impaired when all of the disulfide bonds of both ACE2 and SARS-CoV/CoV-2 spike proteins were reduced to thiol groups.	Sulfhydryl Compounds	167-172	angiotensin converting enzyme 2	Homo sapiens	112-116
32570882-3	2020	It has been shown that high cholesterol levels are associated with more lipid rafts, subdomains of the plasma membrane that can harbour angiotensin-converting enzyme 2 (ACE2) receptors for the S-protein of SARS-CoV-2.	Cholesterol	28-39	angiotensin converting enzyme 2	Homo sapiens	136-167
32570882-3	2020	It has been shown that high cholesterol levels are associated with more lipid rafts, subdomains of the plasma membrane that can harbour angiotensin-converting enzyme 2 (ACE2) receptors for the S-protein of SARS-CoV-2.	Cholesterol	28-39	angiotensin converting enzyme 2	Homo sapiens	169-173
32463098-3	2020	The present study aimed at investigating whether ACE2 is involved in physiological stretch (10% elongation, 1Hz) mediated cellular functions and the underlying mechanism.	1HZ	108-111	angiotensin converting enzyme 2	Homo sapiens	49-53
32665962-4	2020	The concern is that the use of ACEIs and ARBs will increase the expression of ACE2 and increase patient susceptibility to viral host cell entry and propagation.	aceis	31-36	angiotensin converting enzyme 2	Homo sapiens	78-82
32607511-7	2020	When tested against this reporter virus, remdesivir exhibited substantially more potent activity in A549-hACE2 cells compared to Vero E6 cells (EC 50 0.115 vs 1.28 muM), while this difference was not observed for chloroquine (EC 50 1.32 vs 3.52 muM), underscoring the importance of selecting appropriate cells for antiviral testing.	remdesivir	41-51	angiotensin converting enzyme 2	Homo sapiens	105-110
32572334-7	2020	Any disorder in neprilysin, ACE2, and CAs can lead to increase of CO2 concentration in blood and respiratory acidosis, induction of pulmonary edema and heart and renal failures.	Carbon Dioxide	66-69	angiotensin converting enzyme 2	Homo sapiens	28-32
32507883-4	2020	We believe that exaggerated activation of ACE/Angiotensin II (Ang II)/Angiotensin Type 1 (AT1) receptor RAS axis in line with reduction of ACE2/Angiotensin-(1-7)/Mas receptor may exert a pivotal role in the pathogenesis of Covid-19.	Angiotensin II	62-68	angiotensin converting enzyme 2	Homo sapiens	139-143
32538276-10	2021	These studies reported Cefuroxime as a potential inhibitor of 3 key SARS-CoV-2 proteins; main protease, RNA dependent RNA polymerase, and ACE2-Spike complex.	Cefuroxime	23-33	angiotensin converting enzyme 2	Homo sapiens	138-142
32577646-6	2020	Using this technique in combination with molecular modeling also allows the role of heparin in destabilizing the ACE2/RBD association to be studied, providing critical information for understanding the molecular mechanism of its interference with the virus docking to the host cell receptor.	Heparin	84-91	angiotensin converting enzyme 2	Homo sapiens	113-117
32462996-5	2021	Among the studied compounds, we found that dithymoquinone (DTQ), with binding affinity of -8.6 kcal/mol compared to a positive control (chloroquine, -7.2 kcal/mol) , has the high potential of binding at SARS-CoV-2:ACE2 interface and thus could be predicted as a plausible inhibitor to disrupt viral-host interactions.	dithymoquinone	43-57	angiotensin converting enzyme 2	Homo sapiens	214-218
32462996-5	2021	Among the studied compounds, we found that dithymoquinone (DTQ), with binding affinity of -8.6 kcal/mol compared to a positive control (chloroquine, -7.2 kcal/mol) , has the high potential of binding at SARS-CoV-2:ACE2 interface and thus could be predicted as a plausible inhibitor to disrupt viral-host interactions.	dithymoquinone	59-62	angiotensin converting enzyme 2	Homo sapiens	214-218
32545268-4	2020	Our in silico studies show that these flavonoid-based molecules can bind with high affinity to the spike protein, helicase, and protease sites on the ACE2 receptor used by the severe acute respiratory syndrome coronavirus 2 to infect cells and cause COVID-19.	Flavonoids	38-47	angiotensin converting enzyme 2	Homo sapiens	150-154
32545518-5	2020	We found that the potent Nrf2-activating composition PB125  downregulates ACE2 and TMPRSS2 mRNA expression in human liver-derived HepG2 cells.	pb125	53-58	angiotensin converting enzyme 2	Homo sapiens	74-78
32577644-8	2020	Finally, beyond shielding, a possible structural role of N-glycans at N165 and N234 is hypothesized to modulate and stabilize the conformational dynamics of the spike"s receptor binding domain, which is responsible for ACE2 recognition.	n-glycans	57-66	angiotensin converting enzyme 2	Homo sapiens	219-223
32577646-9	2020	The destabilizing effect of heparin is more pronounced in the case of the longer chains due to the electrostatic repulsion between the low-p I ACE2 and the heparin segments not accommodated on the RBD surface.	Heparin	28-35	angiotensin converting enzyme 2	Homo sapiens	143-147
32577646-10	2020	In addition to providing important mechanistic information on attenuation of the ACE2/RBD association by heparin, the study demonstrates the yet untapped potential of native MS coupled to gas-phase ion chemistry as a means of facilitating rational repurposing of the existing medicines for treating COVID-19.	Heparin	105-112	angiotensin converting enzyme 2	Homo sapiens	81-85
32475223-3	2021	The present work is an effort for a computational target to block the residual binding protein (RBP) on spike proteins (S), Angiotensin-Converting Enzyme 2 (ACE2) receptor proteins by probiotics namely Plantaricin BN, Plantaricin JLA-9, Plantaricin W, Plantaricin D along with RNA-dependent RNA polymerase (RdRp).	plantaricin	202-213	angiotensin converting enzyme 2	Homo sapiens	124-155
32532094-3	2020	Here we established a quantitative fusion assay dependent on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S protein, angiotensin I converting enzyme 2 (ACE2) and TMPRSS2, and found that nafamostat mesylate potently inhibited the fusion while camostat mesylate was about 10-fold less active.	nafamostat	202-221	angiotensin converting enzyme 2	Homo sapiens	133-166
32532094-3	2020	Here we established a quantitative fusion assay dependent on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S protein, angiotensin I converting enzyme 2 (ACE2) and TMPRSS2, and found that nafamostat mesylate potently inhibited the fusion while camostat mesylate was about 10-fold less active.	nafamostat	202-221	angiotensin converting enzyme 2	Homo sapiens	168-172
32475223-3	2021	The present work is an effort for a computational target to block the residual binding protein (RBP) on spike proteins (S), Angiotensin-Converting Enzyme 2 (ACE2) receptor proteins by probiotics namely Plantaricin BN, Plantaricin JLA-9, Plantaricin W, Plantaricin D along with RNA-dependent RNA polymerase (RdRp).	plantaricin	202-213	angiotensin converting enzyme 2	Homo sapiens	157-161
32475223-3	2021	The present work is an effort for a computational target to block the residual binding protein (RBP) on spike proteins (S), Angiotensin-Converting Enzyme 2 (ACE2) receptor proteins by probiotics namely Plantaricin BN, Plantaricin JLA-9, Plantaricin W, Plantaricin D along with RNA-dependent RNA polymerase (RdRp).	plantaricin	218-229	angiotensin converting enzyme 2	Homo sapiens	124-155
32475223-3	2021	The present work is an effort for a computational target to block the residual binding protein (RBP) on spike proteins (S), Angiotensin-Converting Enzyme 2 (ACE2) receptor proteins by probiotics namely Plantaricin BN, Plantaricin JLA-9, Plantaricin W, Plantaricin D along with RNA-dependent RNA polymerase (RdRp).	plantaricin	218-229	angiotensin converting enzyme 2	Homo sapiens	157-161
32475223-3	2021	The present work is an effort for a computational target to block the residual binding protein (RBP) on spike proteins (S), Angiotensin-Converting Enzyme 2 (ACE2) receptor proteins by probiotics namely Plantaricin BN, Plantaricin JLA-9, Plantaricin W, Plantaricin D along with RNA-dependent RNA polymerase (RdRp).	plantaricin	218-229	angiotensin converting enzyme 2	Homo sapiens	124-155
32475223-3	2021	The present work is an effort for a computational target to block the residual binding protein (RBP) on spike proteins (S), Angiotensin-Converting Enzyme 2 (ACE2) receptor proteins by probiotics namely Plantaricin BN, Plantaricin JLA-9, Plantaricin W, Plantaricin D along with RNA-dependent RNA polymerase (RdRp).	plantaricin	218-229	angiotensin converting enzyme 2	Homo sapiens	157-161
32475223-3	2021	The present work is an effort for a computational target to block the residual binding protein (RBP) on spike proteins (S), Angiotensin-Converting Enzyme 2 (ACE2) receptor proteins by probiotics namely Plantaricin BN, Plantaricin JLA-9, Plantaricin W, Plantaricin D along with RNA-dependent RNA polymerase (RdRp).	Plantaricin D	252-265	angiotensin converting enzyme 2	Homo sapiens	124-155
32572383-2	2020	The inhibitory capability of active compounds in the TA from Thua Thien Hue, Vietnam over the Angiotensin-Converting Enzyme 2 (ACE2) protein in human body - the host receptor for SARS-CoV-2 and the main protease (PDB6LU7) of the SARS-CoV-2 using docking simulation has been studied herein.	thua thien	61-71	angiotensin converting enzyme 2	Homo sapiens	94-125
32475223-3	2021	The present work is an effort for a computational target to block the residual binding protein (RBP) on spike proteins (S), Angiotensin-Converting Enzyme 2 (ACE2) receptor proteins by probiotics namely Plantaricin BN, Plantaricin JLA-9, Plantaricin W, Plantaricin D along with RNA-dependent RNA polymerase (RdRp).	Plantaricin D	252-265	angiotensin converting enzyme 2	Homo sapiens	157-161
32572383-5	2020	Interestingly, the synergistic interactions of these 10 substances of the TA exhibit excellent inhibition into the ACE2 and PDB6LU7 proteins.	Tantalum	74-76	angiotensin converting enzyme 2	Homo sapiens	115-119
32475223-5	2021	The binding energies for Plantaricin W were -14.64, -11.1 and -12.68 for polymerase, RBD and ACE2 respectively comparatively very high with other compounds.	plantaricin	25-36	angiotensin converting enzyme 2	Homo sapiens	93-97
32577638-4	2020	In addition to its well-documented interaction with its receptor, human angiotensin converting enzyme 2 (hACE2), SGP has been found to bind to glycosaminoglycans like heparan sulfate, which is found on the surface of virtually all mammalian cells.	Heparitin Sulfate	167-182	angiotensin converting enzyme 2	Homo sapiens	72-103
32577638-4	2020	In addition to its well-documented interaction with its receptor, human angiotensin converting enzyme 2 (hACE2), SGP has been found to bind to glycosaminoglycans like heparan sulfate, which is found on the surface of virtually all mammalian cells.	Heparitin Sulfate	167-182	angiotensin converting enzyme 2	Homo sapiens	105-110
32475223-7	2021	Molecular dynamics studies further strengthen stability of the complexes of plantaricin w and SARS-CoV-2 RdRp enzyme, RBD of spike protein, and human ACE2 receptor.	Plantaricin W	76-89	angiotensin converting enzyme 2	Homo sapiens	150-154
33447763-1	2020	Introduction: Emerging epidemiological studies suggested that Renin-Angiotensin-Aldosterone system (RAAS) inhibitors may increase infectivity and severity of COVID-19 by modulating the expression of ACE2.	Aldosterone	80-91	angiotensin converting enzyme 2	Homo sapiens	199-203
32582302-10	2020	SNPs within the ACE2 gene were associated with (1) the use of angiotensin II receptor blockers (ARBs) combination therapies (p = 5.7 x 10-4), an association that is significantly stronger in females (p dif f = 0.01), and (2) with the use of non-steroid anti-inflammatory and antirheumatic products (p = 5.5 x 10-4).	Steroids	245-252	angiotensin converting enzyme 2	Homo sapiens	16-20
33447763-4	2020	Treatment of primary human hepatocytes with captopril, but not enalapril, significantly increased ACE2 expression.	Captopril	44-53	angiotensin converting enzyme 2	Homo sapiens	98-102
32370986-2	2020	Since the ACE2 (angiotensin-converting enzyme 2) enzyme is the receptor that allows SARS COV2 entry into cells, the fear was that pre-existing treatment with ACEi or ARB might increase the risk of developing severe or fatal severe acute respiratory syndrome in case of COVID-19 infection.	acei	158-162	angiotensin converting enzyme 2	Homo sapiens	10-14
32582222-2	2020	A common denominator of all affected organs is the expression of angiotensin-converting enzyme 2 (ACE2), a protease responsible for the conversion of Angiotensin 1-8 (Ang II) to Angiotensin 1-7 (Ang 1-7).	Angiotensin II	167-173	angiotensin converting enzyme 2	Homo sapiens	65-96
32582222-2	2020	A common denominator of all affected organs is the expression of angiotensin-converting enzyme 2 (ACE2), a protease responsible for the conversion of Angiotensin 1-8 (Ang II) to Angiotensin 1-7 (Ang 1-7).	Angiotensin II	167-173	angiotensin converting enzyme 2	Homo sapiens	98-102
32448098-7	2021	The nCoV RBD was found binding to ACE2 receptor with 11 hydrogen bonds and 1 salt bridge.	Hydrogen	56-64	angiotensin converting enzyme 2	Homo sapiens	34-38
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Glutamic Acid	117-120	angiotensin converting enzyme 2	Homo sapiens	187-191
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Tyrosine	125-128	angiotensin converting enzyme 2	Homo sapiens	187-191
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Aspartic Acid	133-136	angiotensin converting enzyme 2	Homo sapiens	187-191
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Lysine	141-144	angiotensin converting enzyme 2	Homo sapiens	187-191
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Glutamic Acid	149-152	angiotensin converting enzyme 2	Homo sapiens	187-191
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Histidine	157-160	angiotensin converting enzyme 2	Homo sapiens	187-191
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Glutamine	205-208	angiotensin converting enzyme 2	Homo sapiens	187-191
32448098-8	2021	The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD.	Lysine	244-247	angiotensin converting enzyme 2	Homo sapiens	187-191
32448098-9	2021	Based on the hydrogen bonding, RMSD and RMSF, total and potential energies, the nCoV was found binding to ACE2 receptor with higher stability and rigidity.	Hydrogen	13-21	angiotensin converting enzyme 2	Homo sapiens	106-110
32412303-3	2020	Like other coronaviruses, SARS-CoV-2 recognizes human angiotensin-converting enzyme 2 as a cellular receptor that allows it to infect different host cells and likely disrupts renin-angiotensin-aldosterone system homeostasis.	Aldosterone	193-204	angiotensin converting enzyme 2	Homo sapiens	54-85
32421367-4	2020	The main host receptor of the SARS-CoV-2 is angiotensin converting enzyme 2 (ACE2), a major component of the renin-angiotensin-aldosterone system (RAAS).	Aldosterone	127-138	angiotensin converting enzyme 2	Homo sapiens	44-75
32421367-4	2020	The main host receptor of the SARS-CoV-2 is angiotensin converting enzyme 2 (ACE2), a major component of the renin-angiotensin-aldosterone system (RAAS).	Aldosterone	127-138	angiotensin converting enzyme 2	Homo sapiens	77-81
32350104-0	2020	COVID-19 and nicotine as a mediator of ACE-2.	Nicotine	13-21	angiotensin converting enzyme 2	Homo sapiens	39-44
32370986-2	2020	Since the ACE2 (angiotensin-converting enzyme 2) enzyme is the receptor that allows SARS COV2 entry into cells, the fear was that pre-existing treatment with ACEi or ARB might increase the risk of developing severe or fatal severe acute respiratory syndrome in case of COVID-19 infection.	acei	158-162	angiotensin converting enzyme 2	Homo sapiens	16-47
32482249-1	2020	OBJECTIVE: To describe detection of severe acute respiratory syndrome (SARS)-coronavirus 2 (CoV-2) in seminal fluid of patients recovering from coronavirus disease 2019 (COVID-19) and to describe the expression profile of angiotensin-converting enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) within the testicle.	Serine	279-285	angiotensin converting enzyme 2	Homo sapiens	222-253
32550040-6	2020	On the other hand, ACE2 negatively regulates the renin-angiotensin-aldosterone system (RAAS) primarily by converting angiotensin II to angiotensin 1-7, which exerts a beneficial effect on coronavirus-induced acute lung injury.	Aldosterone	67-78	angiotensin converting enzyme 2	Homo sapiens	19-23
32568687-9	2020	However compounds like emodin that inhibit SARS entry, apparently by binding ACE2, might also have functions at several different human protein binding sites.	Emodin	23-29	angiotensin converting enzyme 2	Homo sapiens	77-81
32661494-5	2020	Ergotamine, amphotericin b, and vancomycin are most promising to block the interaction of the SARS-CoV-2 S-protein with human ACE-2.	Ergotamine	0-10	angiotensin converting enzyme 2	Homo sapiens	126-131
32661494-5	2020	Ergotamine, amphotericin b, and vancomycin are most promising to block the interaction of the SARS-CoV-2 S-protein with human ACE-2.	Amphotericin B	12-26	angiotensin converting enzyme 2	Homo sapiens	126-131
32661494-5	2020	Ergotamine, amphotericin b, and vancomycin are most promising to block the interaction of the SARS-CoV-2 S-protein with human ACE-2.	Vancomycin	32-42	angiotensin converting enzyme 2	Homo sapiens	126-131
32511366-7	2021	The cholesterol concomitantly traffics angiotensinogen converting enzyme (ACE2) to the viral entry site where SARS-CoV-2 docks to properly exploit entry into the cell.	Cholesterol	4-15	angiotensin converting enzyme 2	Homo sapiens	74-78
32525548-18	2020	Conclusions and Relevance: The correction of hypokalemia is challenging because of continuous renal potassium loss resulting from the degradation of angiotensin-converting enzyme 2.	Potassium	100-109	angiotensin converting enzyme 2	Homo sapiens	149-180
32387238-4	2020	SARS-CoV-2 has a major impact on the Renin Angiotensin Aldosterone System (RAAS), through its binding to the membrane cellular glycoprotein, Angiotensin Converting Enzyme-2 (ACE-2), then infecting cells for replication.	Aldosterone	55-66	angiotensin converting enzyme 2	Homo sapiens	141-172
32387238-4	2020	SARS-CoV-2 has a major impact on the Renin Angiotensin Aldosterone System (RAAS), through its binding to the membrane cellular glycoprotein, Angiotensin Converting Enzyme-2 (ACE-2), then infecting cells for replication.	Aldosterone	55-66	angiotensin converting enzyme 2	Homo sapiens	174-179
32301766-4	2020	In addition, renin-angiotensin aldosterone system inhibitors reduce adverse atherosclerotic cardiovascular disease, heart failure, and chronic kidney disease outcomes, but may increase ACE2 levels.	Aldosterone	31-42	angiotensin converting enzyme 2	Homo sapiens	185-189
32656311-10	2020	Our study exhibited that curcumin, nimbin, withaferin A, piperine, mangiferin, thebaine, berberine, and andrographolide have significant binding affinity towards spike glycoprotein of SARS-CoV-2 and ACE2 receptor and may be useful as a therapeutic and/or prophylactic agent for restricting viral attachment to the host cells.	Curcumin	25-33	angiotensin converting enzyme 2	Homo sapiens	199-203
32656311-10	2020	Our study exhibited that curcumin, nimbin, withaferin A, piperine, mangiferin, thebaine, berberine, and andrographolide have significant binding affinity towards spike glycoprotein of SARS-CoV-2 and ACE2 receptor and may be useful as a therapeutic and/or prophylactic agent for restricting viral attachment to the host cells.	nimbin	35-41	angiotensin converting enzyme 2	Homo sapiens	199-203
32656311-10	2020	Our study exhibited that curcumin, nimbin, withaferin A, piperine, mangiferin, thebaine, berberine, and andrographolide have significant binding affinity towards spike glycoprotein of SARS-CoV-2 and ACE2 receptor and may be useful as a therapeutic and/or prophylactic agent for restricting viral attachment to the host cells.	withaferin A	43-55	angiotensin converting enzyme 2	Homo sapiens	199-203
32656311-10	2020	Our study exhibited that curcumin, nimbin, withaferin A, piperine, mangiferin, thebaine, berberine, and andrographolide have significant binding affinity towards spike glycoprotein of SARS-CoV-2 and ACE2 receptor and may be useful as a therapeutic and/or prophylactic agent for restricting viral attachment to the host cells.	piperine	57-65	angiotensin converting enzyme 2	Homo sapiens	199-203
32656311-10	2020	Our study exhibited that curcumin, nimbin, withaferin A, piperine, mangiferin, thebaine, berberine, and andrographolide have significant binding affinity towards spike glycoprotein of SARS-CoV-2 and ACE2 receptor and may be useful as a therapeutic and/or prophylactic agent for restricting viral attachment to the host cells.	mangiferin	67-77	angiotensin converting enzyme 2	Homo sapiens	199-203
32656311-10	2020	Our study exhibited that curcumin, nimbin, withaferin A, piperine, mangiferin, thebaine, berberine, and andrographolide have significant binding affinity towards spike glycoprotein of SARS-CoV-2 and ACE2 receptor and may be useful as a therapeutic and/or prophylactic agent for restricting viral attachment to the host cells.	Thebaine	79-87	angiotensin converting enzyme 2	Homo sapiens	199-203
32656311-10	2020	Our study exhibited that curcumin, nimbin, withaferin A, piperine, mangiferin, thebaine, berberine, and andrographolide have significant binding affinity towards spike glycoprotein of SARS-CoV-2 and ACE2 receptor and may be useful as a therapeutic and/or prophylactic agent for restricting viral attachment to the host cells.	Berberine	89-98	angiotensin converting enzyme 2	Homo sapiens	199-203
32656311-10	2020	Our study exhibited that curcumin, nimbin, withaferin A, piperine, mangiferin, thebaine, berberine, and andrographolide have significant binding affinity towards spike glycoprotein of SARS-CoV-2 and ACE2 receptor and may be useful as a therapeutic and/or prophylactic agent for restricting viral attachment to the host cells.	andrographolide	104-119	angiotensin converting enzyme 2	Homo sapiens	199-203
32656311-11	2020	However, few other natural products like resveratrol, quercetin, luteolin, naringenin, zingiberene, and gallic acid has the significant binding affinity towards ACE2 receptor only and therefore may be used for ACE2-mediated attachment inhibition of SARS-CoV-2.	Resveratrol	41-52	angiotensin converting enzyme 2	Homo sapiens	161-165
32656311-11	2020	However, few other natural products like resveratrol, quercetin, luteolin, naringenin, zingiberene, and gallic acid has the significant binding affinity towards ACE2 receptor only and therefore may be used for ACE2-mediated attachment inhibition of SARS-CoV-2.	Resveratrol	41-52	angiotensin converting enzyme 2	Homo sapiens	210-214
32656311-11	2020	However, few other natural products like resveratrol, quercetin, luteolin, naringenin, zingiberene, and gallic acid has the significant binding affinity towards ACE2 receptor only and therefore may be used for ACE2-mediated attachment inhibition of SARS-CoV-2.	Quercetin	54-63	angiotensin converting enzyme 2	Homo sapiens	161-165
32656311-11	2020	However, few other natural products like resveratrol, quercetin, luteolin, naringenin, zingiberene, and gallic acid has the significant binding affinity towards ACE2 receptor only and therefore may be used for ACE2-mediated attachment inhibition of SARS-CoV-2.	Quercetin	54-63	angiotensin converting enzyme 2	Homo sapiens	210-214
32656311-11	2020	However, few other natural products like resveratrol, quercetin, luteolin, naringenin, zingiberene, and gallic acid has the significant binding affinity towards ACE2 receptor only and therefore may be used for ACE2-mediated attachment inhibition of SARS-CoV-2.	Luteolin	65-73	angiotensin converting enzyme 2	Homo sapiens	161-165
32656311-11	2020	However, few other natural products like resveratrol, quercetin, luteolin, naringenin, zingiberene, and gallic acid has the significant binding affinity towards ACE2 receptor only and therefore may be used for ACE2-mediated attachment inhibition of SARS-CoV-2.	Luteolin	65-73	angiotensin converting enzyme 2	Homo sapiens	210-214
32656311-11	2020	However, few other natural products like resveratrol, quercetin, luteolin, naringenin, zingiberene, and gallic acid has the significant binding affinity towards ACE2 receptor only and therefore may be used for ACE2-mediated attachment inhibition of SARS-CoV-2.	naringenin	75-85	angiotensin converting enzyme 2	Homo sapiens	161-165
32656311-11	2020	However, few other natural products like resveratrol, quercetin, luteolin, naringenin, zingiberene, and gallic acid has the significant binding affinity towards ACE2 receptor only and therefore may be used for ACE2-mediated attachment inhibition of SARS-CoV-2.	naringenin	75-85	angiotensin converting enzyme 2	Homo sapiens	210-214
32656311-11	2020	However, few other natural products like resveratrol, quercetin, luteolin, naringenin, zingiberene, and gallic acid has the significant binding affinity towards ACE2 receptor only and therefore may be used for ACE2-mediated attachment inhibition of SARS-CoV-2.	zingiberene	87-98	angiotensin converting enzyme 2	Homo sapiens	161-165
32656311-11	2020	However, few other natural products like resveratrol, quercetin, luteolin, naringenin, zingiberene, and gallic acid has the significant binding affinity towards ACE2 receptor only and therefore may be used for ACE2-mediated attachment inhibition of SARS-CoV-2.	zingiberene	87-98	angiotensin converting enzyme 2	Homo sapiens	210-214
32656311-11	2020	However, few other natural products like resveratrol, quercetin, luteolin, naringenin, zingiberene, and gallic acid has the significant binding affinity towards ACE2 receptor only and therefore may be used for ACE2-mediated attachment inhibition of SARS-CoV-2.	Gallic Acid	104-115	angiotensin converting enzyme 2	Homo sapiens	161-165
32656311-11	2020	However, few other natural products like resveratrol, quercetin, luteolin, naringenin, zingiberene, and gallic acid has the significant binding affinity towards ACE2 receptor only and therefore may be used for ACE2-mediated attachment inhibition of SARS-CoV-2.	Gallic Acid	104-115	angiotensin converting enzyme 2	Homo sapiens	210-214
32534505-0	2020	Sitagliptin Repositioning in SARS-CoV-2: Effects on ACE-2, CD-26, and Inflammatory Cytokine Storms in the Lung.	Sitagliptin Phosphate	0-11	angiotensin converting enzyme 2	Homo sapiens	52-57
32201080-6	2020	We identified that N82 in ACE2 showed a closer contact with SARS-CoV-2 S protein than M82 in human ACE2.	N82	19-22	angiotensin converting enzyme 2	Homo sapiens	26-30
32201080-6	2020	We identified that N82 in ACE2 showed a closer contact with SARS-CoV-2 S protein than M82 in human ACE2.	N82	19-22	angiotensin converting enzyme 2	Homo sapiens	99-103
32511372-5	2020	We found that the potent Nrf2 activating composition PB125  downregulates ACE2 and TMPRSS2 mRNA expression in human liver-derived HepG2 cells.	pb125	53-58	angiotensin converting enzyme 2	Homo sapiens	74-78
32574273-6	2020	ACE2 is part of the wider renin-angiotensin-aldosterone system (RAAS) and is upregulated via compounds, which inhibits the classical ACE, thereby plasma aldosterone and aldosterone receptor (MR) activation.	Aldosterone	44-55	angiotensin converting enzyme 2	Homo sapiens	0-4
32574273-6	2020	ACE2 is part of the wider renin-angiotensin-aldosterone system (RAAS) and is upregulated via compounds, which inhibits the classical ACE, thereby plasma aldosterone and aldosterone receptor (MR) activation.	Aldosterone	153-164	angiotensin converting enzyme 2	Homo sapiens	0-4
32574273-11	2020	Importantly, GL has anti-inflammatory properties by itself via toll like receptor 4 (TLR4) antagonism and therefore compensates for the reduced protection of the downregulated ACE2.	Glycyrrhizic Acid	13-15	angiotensin converting enzyme 2	Homo sapiens	176-180
32325025-3	2020	(Cell) identify ACE2 as a SARS-CoV-2 receptor, and the latter show its entry mechanism depends on cellular serine protease TMPRSS2.	Serine	107-113	angiotensin converting enzyme 2	Homo sapiens	16-20
32435607-4	2020	As a crucial enzyme of renin-angiotensin-aldosterone system (RAAS), ACE2 not only mediates the virus entry but also affects the pathophysiological process of virus-induced acute lung injury (ALI), as well as other organs" damage.	Aldosterone	41-52	angiotensin converting enzyme 2	Homo sapiens	68-72
32375574-2	2021	This study demonstrated the putative inhibitory potential of lopinavir, remdesivir, oseltamir, azithromycin, ribavirin, and chloroquine towards V-ATPase, protein kinase A, SARS-CoV spike glycoprotein/ACE-2 complex and viral proteases.	Lopinavir	61-70	angiotensin converting enzyme 2	Homo sapiens	200-205
32375574-2	2021	This study demonstrated the putative inhibitory potential of lopinavir, remdesivir, oseltamir, azithromycin, ribavirin, and chloroquine towards V-ATPase, protein kinase A, SARS-CoV spike glycoprotein/ACE-2 complex and viral proteases.	remdesivir	72-82	angiotensin converting enzyme 2	Homo sapiens	200-205
32375574-2	2021	This study demonstrated the putative inhibitory potential of lopinavir, remdesivir, oseltamir, azithromycin, ribavirin, and chloroquine towards V-ATPase, protein kinase A, SARS-CoV spike glycoprotein/ACE-2 complex and viral proteases.	oseltamir	84-93	angiotensin converting enzyme 2	Homo sapiens	200-205
32375574-2	2021	This study demonstrated the putative inhibitory potential of lopinavir, remdesivir, oseltamir, azithromycin, ribavirin, and chloroquine towards V-ATPase, protein kinase A, SARS-CoV spike glycoprotein/ACE-2 complex and viral proteases.	Azithromycin	95-107	angiotensin converting enzyme 2	Homo sapiens	200-205
32375574-2	2021	This study demonstrated the putative inhibitory potential of lopinavir, remdesivir, oseltamir, azithromycin, ribavirin, and chloroquine towards V-ATPase, protein kinase A, SARS-CoV spike glycoprotein/ACE-2 complex and viral proteases.	Ribavirin	109-118	angiotensin converting enzyme 2	Homo sapiens	200-205
32375574-2	2021	This study demonstrated the putative inhibitory potential of lopinavir, remdesivir, oseltamir, azithromycin, ribavirin, and chloroquine towards V-ATPase, protein kinase A, SARS-CoV spike glycoprotein/ACE-2 complex and viral proteases.	Chloroquine	124-135	angiotensin converting enzyme 2	Homo sapiens	200-205
32375574-5	2021	Lopinavir has the highest binding affinities to the pocket site of SARS-CoV spike glycoprotein/ACE-2 complex, cyclic AMP-dependent protein kinase A and 3-Chymotrypsin like protease while redemsivir has the highest binding affinities for vacuolar proton-translocating ATPase (V-ATPase) and papain-like proteins.	Lopinavir	0-9	angiotensin converting enzyme 2	Homo sapiens	95-100
32375574-6	2021	The amino acids Asp269, Leu370, His374, and His345 were predicted as the key residues for lopinavir binding to human SARS-CoV spike glycoprotein/ACE-2 complex while His378, Tyr515, Leu73, Leu100, Phe32 and Phe40 for remdesivir and Tyr510, Phe504, Met62, Tyr50, and His378 were predicted for azithromycin as the key residues for binding to SARS-CoV spike glycoprotein/ACE-2 complex.	Lopinavir	90-99	angiotensin converting enzyme 2	Homo sapiens	145-150
32375574-6	2021	The amino acids Asp269, Leu370, His374, and His345 were predicted as the key residues for lopinavir binding to human SARS-CoV spike glycoprotein/ACE-2 complex while His378, Tyr515, Leu73, Leu100, Phe32 and Phe40 for remdesivir and Tyr510, Phe504, Met62, Tyr50, and His378 were predicted for azithromycin as the key residues for binding to SARS-CoV spike glycoprotein/ACE-2 complex.	Lopinavir	90-99	angiotensin converting enzyme 2	Homo sapiens	367-372
32333601-12	2020	Anti-tumor necrosis factor drugs, vedolizumab, ustekinumab, and steroids were linked to significantly lower expression of ACE2 in CD11b-enriched cells.	Steroids	64-72	angiotensin converting enzyme 2	Homo sapiens	122-126
32511360-6	2020	Treatment with the 5 alpha reductase inhibitor dutasteride reduced ACE2 levels and internalization of recombinant spike receptor binding domain (Spike-RBD) in hESC-derived cardiac cells and human alveolar epithelial cells.	Dutasteride	47-58	angiotensin converting enzyme 2	Homo sapiens	67-71
32401442-1	2020	ACE2 is not only an enzyme that counters the effects of the renin-angiotensin-aldosterone system (RAAS) but is also the entry receptor for SARS-CoV-2, the virus of the Covid-19 pandemic.	Aldosterone	78-89	angiotensin converting enzyme 2	Homo sapiens	0-4
32228252-5	2020	Moreover, experimental evidence suggests that RAAS blockade by ACE inhibitors, ANG II type 1 receptor antagonists, and mineralocorticoid antagonists, as well as statins, enhance ACE2 which, in part, contributes to the benefit of these regimens.	inhibitors	67-77	angiotensin converting enzyme 2	Homo sapiens	178-182
32169277-4	2020	Our data showed PSS induced a sustained ACE2 expression, but OSS only induced a transient ACE2 expression.	pss	16-19	angiotensin converting enzyme 2	Homo sapiens	40-44
32169277-4	2020	Our data showed PSS induced a sustained ACE2 expression, but OSS only induced a transient ACE2 expression.	OSS	61-64	angiotensin converting enzyme 2	Homo sapiens	90-94
32169277-5	2020	The PSS-induced ACE2 expression was higher than that of OSS both in vitro and in vivo.	pss	4-7	angiotensin converting enzyme 2	Homo sapiens	16-20
32169277-6	2020	The PSS-induced ACE2 was involved in inhibiting proliferation and inflammation, as well as promoting NO production in ECs.	pss	4-7	angiotensin converting enzyme 2	Homo sapiens	16-20
32169277-7	2020	PSS significantly increased ACE2 expression at transcriptional level via activating AMPKalpha2-KLF2 pathway.	pss	0-3	angiotensin converting enzyme 2	Homo sapiens	28-32
32169277-8	2020	CONCLUSIONS: Our results suggest PSS promotes ACE2 expression via AMPKalpha2-KLF2 pathway to maintain the normal EC functions.	pss	33-36	angiotensin converting enzyme 2	Homo sapiens	46-50
32228252-4	2020	ACE2, however, is a key enzymatic component of the renin-angiotensin-aldosterone system (RAAS); ACE2 degrades ANG II, a peptide with multiple actions that promote CVD, and generates Ang-(1-7), which antagonizes the effects of ANG II.	Aldosterone	69-80	angiotensin converting enzyme 2	Homo sapiens	0-4
32228252-4	2020	ACE2, however, is a key enzymatic component of the renin-angiotensin-aldosterone system (RAAS); ACE2 degrades ANG II, a peptide with multiple actions that promote CVD, and generates Ang-(1-7), which antagonizes the effects of ANG II.	Aldosterone	69-80	angiotensin converting enzyme 2	Homo sapiens	96-100
32310688-4	2020	A high intake of resveratrol may have a protective role, upregulating ACE2, whereas a high intake of dietary fat may have a detrimental role, downregulating ACE2.	Resveratrol	17-28	angiotensin converting enzyme 2	Homo sapiens	70-74
32251731-4	2020	The S protein uses the angiotension-converting enzyme-2 (ACE-2) receptor for entry, but also sialic acids linked to host cell surface gangliosides.	angiotension	23-35	angiotensin converting enzyme 2	Homo sapiens	57-62
31901211-0	2020	The potential actions of angiotensin-converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases.	diminazene aceturate	75-95	angiotensin converting enzyme 2	Homo sapiens	59-63
31901211-0	2020	The potential actions of angiotensin-converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases.	diminazene aceturate	97-101	angiotensin converting enzyme 2	Homo sapiens	59-63
31901211-4	2020	Furthermore, ACE2 converts AngA into another vasodilator named alamandine.	alamandine	63-73	angiotensin converting enzyme 2	Homo sapiens	13-17
31901211-10	2020	The antitrypanosomal agent, diminazene aceturate (DIZE), is one approach in activating ACE2.	diminazene aceturate	28-48	angiotensin converting enzyme 2	Homo sapiens	87-91
31901211-10	2020	The antitrypanosomal agent, diminazene aceturate (DIZE), is one approach in activating ACE2.	diminazene aceturate	50-54	angiotensin converting enzyme 2	Homo sapiens	87-91
33912790-7	2020	Only antibodies competed with ACE2 can bind to the free RBD-His in the supernatant and be subsequently separated by the nickel-nitrilotriacetic acid magnetic beads.	rbd-his	56-63	angiotensin converting enzyme 2	Homo sapiens	30-34
32238438-10	2020	Moreover, we predict that nicotine exposure through various kinds of smoking (cigarettes, electronic cigarettes, or vape) can increase the risk for COVID19 neuroinfection based on known functional interactions between the nicotinic receptor and ACE2.	Nicotine	26-34	angiotensin converting enzyme 2	Homo sapiens	245-249
32576357-1	2020	2019 Novel coronavirus (2019-nCoV) destroys angiotensin converting enzyme 2 (ACE2) and breaks the balance of renin-angiotension system (RAS) by interacting with ACE2.	angiotension	115-127	angiotensin converting enzyme 2	Homo sapiens	44-75
32576357-1	2020	2019 Novel coronavirus (2019-nCoV) destroys angiotensin converting enzyme 2 (ACE2) and breaks the balance of renin-angiotension system (RAS) by interacting with ACE2.	angiotension	115-127	angiotensin converting enzyme 2	Homo sapiens	77-81
32576357-1	2020	2019 Novel coronavirus (2019-nCoV) destroys angiotensin converting enzyme 2 (ACE2) and breaks the balance of renin-angiotension system (RAS) by interacting with ACE2.	angiotension	115-127	angiotensin converting enzyme 2	Homo sapiens	161-165
33912790-7	2020	Only antibodies competed with ACE2 can bind to the free RBD-His in the supernatant and be subsequently separated by the nickel-nitrilotriacetic acid magnetic beads.	Nickel	120-126	angiotensin converting enzyme 2	Homo sapiens	30-34
33912790-7	2020	Only antibodies competed with ACE2 can bind to the free RBD-His in the supernatant and be subsequently separated by the nickel-nitrilotriacetic acid magnetic beads.	Nitrilotriacetic Acid	127-148	angiotensin converting enzyme 2	Homo sapiens	30-34
32339157-1	2020	Angiotensin-converting enzyme 2 (ACE2) is a member of the renin-angiotension system, however, the correlation between ACE2 and prognosis in UCEC (Uterine Corpus Endometrial Carcinoma) and KIRP (Kidney Renal Papillary Cell Carcinoma) is not clear.	angiotension	64-76	angiotensin converting enzyme 2	Homo sapiens	0-31
32339157-1	2020	Angiotensin-converting enzyme 2 (ACE2) is a member of the renin-angiotension system, however, the correlation between ACE2 and prognosis in UCEC (Uterine Corpus Endometrial Carcinoma) and KIRP (Kidney Renal Papillary Cell Carcinoma) is not clear.	angiotension	64-76	angiotensin converting enzyme 2	Homo sapiens	33-37
32354022-4	2020	ACE2 plays an essential role in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure and fluid balance.	Aldosterone	54-65	angiotensin converting enzyme 2	Homo sapiens	0-4
32339157-1	2020	Angiotensin-converting enzyme 2 (ACE2) is a member of the renin-angiotension system, however, the correlation between ACE2 and prognosis in UCEC (Uterine Corpus Endometrial Carcinoma) and KIRP (Kidney Renal Papillary Cell Carcinoma) is not clear.	angiotension	64-76	angiotensin converting enzyme 2	Homo sapiens	118-122
32268515-7	2020	Our results demonstrate that the genes correlated with ACE2 are mainly enriched in the sterol biosynthetic process, Aryldialkylphosphatase activity, adenosylhomocysteinase activity, trialkylsulfonium hydrolase activity, acetate-CoA and CoA ligase activity.	Sterols	87-93	angiotensin converting enzyme 2	Homo sapiens	55-59
32331343-4	2020	Data on the experimental animal have shown that 17ss-estradiol increases the expression and activity of ACE2 in both adipose tissue and kidney.	17ss-estradiol	48-62	angiotensin converting enzyme 2	Homo sapiens	104-108
32227122-10	2020	Alamandine shifted the balance of RAS toward the ACE2/alamandine/MrgD axis, and inhibited both Ang II-induced ROS and autophagy activation, leading to attenuation of HSCs migration or collagen synthesis.	alamandine	0-10	angiotensin converting enzyme 2	Homo sapiens	49-53
32314329-2	2020	ACE2 counteracts ACE and angiotensin II in the renin-angiotensin-aldosterone system (RAAS) and has critical functions in the lung and cardiovascular system.	Aldosterone	65-76	angiotensin converting enzyme 2	Homo sapiens	0-4
32250244-1	2020	The discovery of angiotensin converting enzyme-2 (ACE-2) as the receptor for SARS- CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) has implicated the renin-angiotensin-aldosterone system in acute respiratory distress syndrome (ARDS) and respiratory failure in patients with coronavirus disease-19 (COVID-19).	Aldosterone	176-187	angiotensin converting enzyme 2	Homo sapiens	17-48
32250244-1	2020	The discovery of angiotensin converting enzyme-2 (ACE-2) as the receptor for SARS- CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) has implicated the renin-angiotensin-aldosterone system in acute respiratory distress syndrome (ARDS) and respiratory failure in patients with coronavirus disease-19 (COVID-19).	Aldosterone	176-187	angiotensin converting enzyme 2	Homo sapiens	50-55
32268515-7	2020	Our results demonstrate that the genes correlated with ACE2 are mainly enriched in the sterol biosynthetic process, Aryldialkylphosphatase activity, adenosylhomocysteinase activity, trialkylsulfonium hydrolase activity, acetate-CoA and CoA ligase activity.	Acetates	220-227	angiotensin converting enzyme 2	Homo sapiens	55-59
32081428-6	2020	A unique phenylalanine F486 in the flexible loop likely plays a major role because its penetration into a deep hydrophobic pocket in ACE2.	phenylalanine f486	9-27	angiotensin converting enzyme 2	Homo sapiens	133-137
32065055-7	2020	Interestingly, some of the most potent SARS-CoV-specific neutralizing antibodies (e.g. m396, CR3014) that target the ACE2 binding site of SARS-CoV failed to bind 2019-nCoV spike protein, implying that the difference in the RBD of SARS-CoV and 2019-nCoV has a critical impact for the cross-reactivity of neutralizing antibodies, and that it is still necessary to develop novel monoclonal antibodies that could bind specifically to 2019-nCoV RBD.	cr3014	93-99	angiotensin converting enzyme 2	Homo sapiens	117-121
32577056-3	2020	S-protein of the virus was binding to ACE2 receptors caused downregulation of endogenous anti-viral mediators, upregulation of NF-kappaB pathway, ROS and pro-apoptotic protein.	ros	146-149	angiotensin converting enzyme 2	Homo sapiens	38-42
32611305-6	2020	Intravenous infusions of ACEIs and ARBs in experimental animals increase the number of ACE2 receptors.	aceis	25-30	angiotensin converting enzyme 2	Homo sapiens	87-91
31643111-1	2020	Diminazene aceturate (DIZE) is an anti-protozoan compound that has been previously reported to increase the activity of the angiotensin-converting enzyme 2 (ACE2) and thus increase Angiotensin-(1-7) production, leading to cardioprotection against post-myocardial infarction dysfunction and structural remodelling.	diminazene aceturate	0-20	angiotensin converting enzyme 2	Homo sapiens	124-155
31643111-1	2020	Diminazene aceturate (DIZE) is an anti-protozoan compound that has been previously reported to increase the activity of the angiotensin-converting enzyme 2 (ACE2) and thus increase Angiotensin-(1-7) production, leading to cardioprotection against post-myocardial infarction dysfunction and structural remodelling.	diminazene aceturate	0-20	angiotensin converting enzyme 2	Homo sapiens	157-161
31643111-1	2020	Diminazene aceturate (DIZE) is an anti-protozoan compound that has been previously reported to increase the activity of the angiotensin-converting enzyme 2 (ACE2) and thus increase Angiotensin-(1-7) production, leading to cardioprotection against post-myocardial infarction dysfunction and structural remodelling.	diminazene aceturate	22-26	angiotensin converting enzyme 2	Homo sapiens	124-155
31643111-1	2020	Diminazene aceturate (DIZE) is an anti-protozoan compound that has been previously reported to increase the activity of the angiotensin-converting enzyme 2 (ACE2) and thus increase Angiotensin-(1-7) production, leading to cardioprotection against post-myocardial infarction dysfunction and structural remodelling.	diminazene aceturate	22-26	angiotensin converting enzyme 2	Homo sapiens	157-161
32985211-6	2020	Resveratrol was shown to mitigate the major pathways involved in the pathogenesis of SARS-CoV-2, including regulation of the renin-angiotensin system (RAS) and expression of angiotensin-converting enzyme 2 (ACE2), stimulation of immune system and downregulation of pro-inflammatory cytokines release.	Resveratrol	0-11	angiotensin converting enzyme 2	Homo sapiens	174-205
32985211-6	2020	Resveratrol was shown to mitigate the major pathways involved in the pathogenesis of SARS-CoV-2, including regulation of the renin-angiotensin system (RAS) and expression of angiotensin-converting enzyme 2 (ACE2), stimulation of immune system and downregulation of pro-inflammatory cytokines release.	Resveratrol	0-11	angiotensin converting enzyme 2	Homo sapiens	207-211
32540737-6	2020	RESULTS: Medications, including pioglitazone, that upregulate tissue expression of angiotensin converting enzyme 2 (ACE2), might have a dual role in COVID-19; on the one hand they might increase risk of infection as SARS-CoV2 uses ACE2 as a coreceptor to enter alveolar cells, but on the other hand, by reducing angiotensin II levels, they can protect against acute lung injury.	Pioglitazone	32-44	angiotensin converting enzyme 2	Homo sapiens	83-114
33200026-0	2020	Chinese herbal compounds against SARS-CoV-2: puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor.	puerarin	45-53	angiotensin converting enzyme 2	Homo sapiens	109-113
33200026-0	2020	Chinese herbal compounds against SARS-CoV-2: puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor.	Quercetin	58-67	angiotensin converting enzyme 2	Homo sapiens	109-113
33200026-3	2020	Here, we identified puerarin (PubChem CID: 5281807), quercetin (PubChem CID: 5280343) and kaempferol (PubChem CID: 5280863) as potential compounds with binding activity to ACE2 by using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP).	puerarin	20-28	angiotensin converting enzyme 2	Homo sapiens	172-176
33200026-3	2020	Here, we identified puerarin (PubChem CID: 5281807), quercetin (PubChem CID: 5280343) and kaempferol (PubChem CID: 5280863) as potential compounds with binding activity to ACE2 by using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP).	kaempferol	90-100	angiotensin converting enzyme 2	Homo sapiens	172-176
33200026-4	2020	Molecular docking analysis showed that puerarin and quercetin exhibit good binding affinity to ACE2, which was validated by surface plasmon resonance (SPR) assay.	puerarin	39-47	angiotensin converting enzyme 2	Homo sapiens	95-99
33200026-4	2020	Molecular docking analysis showed that puerarin and quercetin exhibit good binding affinity to ACE2, which was validated by surface plasmon resonance (SPR) assay.	Quercetin	52-61	angiotensin converting enzyme 2	Homo sapiens	95-99
33200026-5	2020	Furthermore, SPR-based competition assay revealed that puerarin and quercetin could significantly affect the binding of viral S-protein to ACE2 receptor.	puerarin	55-63	angiotensin converting enzyme 2	Homo sapiens	139-143
33200026-5	2020	Furthermore, SPR-based competition assay revealed that puerarin and quercetin could significantly affect the binding of viral S-protein to ACE2 receptor.	Quercetin	68-77	angiotensin converting enzyme 2	Homo sapiens	139-143
33200028-4	2020	Here, we observed Val-to-Lys417 mutation in the receptor-binding domains (RBD) of SARS-CoV-2, which established a Lys-Asp electrostatic interaction enhancing its ACE2-binding.	Valine	18-21	angiotensin converting enzyme 2	Homo sapiens	162-166
33200028-4	2020	Here, we observed Val-to-Lys417 mutation in the receptor-binding domains (RBD) of SARS-CoV-2, which established a Lys-Asp electrostatic interaction enhancing its ACE2-binding.	Lysine	114-118	angiotensin converting enzyme 2	Homo sapiens	162-166
33200028-4	2020	Here, we observed Val-to-Lys417 mutation in the receptor-binding domains (RBD) of SARS-CoV-2, which established a Lys-Asp electrostatic interaction enhancing its ACE2-binding.	Aspartic Acid	118-121	angiotensin converting enzyme 2	Homo sapiens	162-166
33250972-4	2020	Our analysis of retrieved amino acid sequences deposited in data bases shows that S-proteins and ACE2 are rich in cysteine (Cys) residues, many of which are conserved in various SARS-related coronaviruses and participate in intra-molecular disulfide bonds.	Cysteine	114-122	angiotensin converting enzyme 2	Homo sapiens	97-101
33250972-4	2020	Our analysis of retrieved amino acid sequences deposited in data bases shows that S-proteins and ACE2 are rich in cysteine (Cys) residues, many of which are conserved in various SARS-related coronaviruses and participate in intra-molecular disulfide bonds.	Cysteine	124-127	angiotensin converting enzyme 2	Homo sapiens	97-101
33250972-4	2020	Our analysis of retrieved amino acid sequences deposited in data bases shows that S-proteins and ACE2 are rich in cysteine (Cys) residues, many of which are conserved in various SARS-related coronaviruses and participate in intra-molecular disulfide bonds.	Disulfides	240-249	angiotensin converting enzyme 2	Homo sapiens	97-101
33250972-5	2020	High-resolution protein structures of S-proteins and ACE2 receptors highlighted the probability that two of these disulfide bonds are potentially redox-active, facilitating the primal interaction between the receptor and the spike protein.	Disulfides	114-123	angiotensin converting enzyme 2	Homo sapiens	53-57
33250972-6	2020	Presence of redox-active disulfides in the interacting parts of S-protein, ACE2, and a ferredoxin-like fold domain in the transmembrane part of ACE2, strongly indicate the role of redox in COVID-19 pathogenesis and severity.	Disulfides	25-35	angiotensin converting enzyme 2	Homo sapiens	75-79
33250972-6	2020	Presence of redox-active disulfides in the interacting parts of S-protein, ACE2, and a ferredoxin-like fold domain in the transmembrane part of ACE2, strongly indicate the role of redox in COVID-19 pathogenesis and severity.	Disulfides	25-35	angiotensin converting enzyme 2	Homo sapiens	144-148
33250972-7	2020	Resistant animals lack a redox-active disulfide (Cys133-Cys141) in ACE2 sequences, further strengthening the redox hypothesis for infectivity.	Disulfides	38-47	angiotensin converting enzyme 2	Homo sapiens	67-71
32540737-6	2020	RESULTS: Medications, including pioglitazone, that upregulate tissue expression of angiotensin converting enzyme 2 (ACE2), might have a dual role in COVID-19; on the one hand they might increase risk of infection as SARS-CoV2 uses ACE2 as a coreceptor to enter alveolar cells, but on the other hand, by reducing angiotensin II levels, they can protect against acute lung injury.	Pioglitazone	32-44	angiotensin converting enzyme 2	Homo sapiens	116-120
32540737-6	2020	RESULTS: Medications, including pioglitazone, that upregulate tissue expression of angiotensin converting enzyme 2 (ACE2), might have a dual role in COVID-19; on the one hand they might increase risk of infection as SARS-CoV2 uses ACE2 as a coreceptor to enter alveolar cells, but on the other hand, by reducing angiotensin II levels, they can protect against acute lung injury.	Pioglitazone	32-44	angiotensin converting enzyme 2	Homo sapiens	231-235
33196058-4	2020	ACE2 is integral to the renin-angiotensin-aldosterone system (RAAS), and SARS-CoV-2 down-regulates protein expression levels of ACE2.	Aldosterone	42-53	angiotensin converting enzyme 2	Homo sapiens	0-4
32311651-5	2020	ACEIs and ARBs lead to a reduction in angiotensin II level by increasing the ACE2 level, thus they cause a low cytosolic pH.	aceis	0-5	angiotensin converting enzyme 2	Homo sapiens	77-81
32311651-6	2020	Increased cardiac ACE2 levels due to ACEIs and ARBs can trigger cardiac arrhythmias and myocarditis by causing the virus to easily enter the heart tissue.	aceis	37-42	angiotensin converting enzyme 2	Homo sapiens	18-22
32428864-5	2020	In this view, we highlighted potential approaches to address ACE2-mediated SARS-CoV-2 virus, including 1) delivering an excessive soluble form of ACE2 (recombinant human ACE2: rhACE2) and 2) inhibition of the interaction between SARS-CoV-2 virus and ACE2 by some compounds with competitive effects (morphine and codeine).	rhace2	176-182	angiotensin converting enzyme 2	Homo sapiens	61-65
32428864-5	2020	In this view, we highlighted potential approaches to address ACE2-mediated SARS-CoV-2 virus, including 1) delivering an excessive soluble form of ACE2 (recombinant human ACE2: rhACE2) and 2) inhibition of the interaction between SARS-CoV-2 virus and ACE2 by some compounds with competitive effects (morphine and codeine).	rhace2	176-182	angiotensin converting enzyme 2	Homo sapiens	146-150
32428864-5	2020	In this view, we highlighted potential approaches to address ACE2-mediated SARS-CoV-2 virus, including 1) delivering an excessive soluble form of ACE2 (recombinant human ACE2: rhACE2) and 2) inhibition of the interaction between SARS-CoV-2 virus and ACE2 by some compounds with competitive effects (morphine and codeine).	rhace2	176-182	angiotensin converting enzyme 2	Homo sapiens	146-150
32428864-5	2020	In this view, we highlighted potential approaches to address ACE2-mediated SARS-CoV-2 virus, including 1) delivering an excessive soluble form of ACE2 (recombinant human ACE2: rhACE2) and 2) inhibition of the interaction between SARS-CoV-2 virus and ACE2 by some compounds with competitive effects (morphine and codeine).	rhace2	176-182	angiotensin converting enzyme 2	Homo sapiens	146-150
32428864-5	2020	In this view, we highlighted potential approaches to address ACE2-mediated SARS-CoV-2 virus, including 1) delivering an excessive soluble form of ACE2 (recombinant human ACE2: rhACE2) and 2) inhibition of the interaction between SARS-CoV-2 virus and ACE2 by some compounds with competitive effects (morphine and codeine).	Morphine	299-307	angiotensin converting enzyme 2	Homo sapiens	61-65
32428864-5	2020	In this view, we highlighted potential approaches to address ACE2-mediated SARS-CoV-2 virus, including 1) delivering an excessive soluble form of ACE2 (recombinant human ACE2: rhACE2) and 2) inhibition of the interaction between SARS-CoV-2 virus and ACE2 by some compounds with competitive effects (morphine and codeine).	Codeine	312-319	angiotensin converting enzyme 2	Homo sapiens	61-65
33196058-4	2020	ACE2 is integral to the renin-angiotensin-aldosterone system (RAAS), and SARS-CoV-2 down-regulates protein expression levels of ACE2.	Aldosterone	42-53	angiotensin converting enzyme 2	Homo sapiens	128-132
32835160-6	2020	Conclusion: Since there are around 192 million people using cannabis worldwide, we believe that the mechanism underlying the hypotensive properties of cannabinoids should be urgently studied to understand if they can also lead to ACE-2 overexpression as other antihypertensive drugs do.	Cannabinoids	151-163	angiotensin converting enzyme 2	Homo sapiens	230-235
32553503-7	2020	In vitro, both ARBs and ACEi appear able to upregulate ACE2 tissue expression and activity but these results were not confirmed in Humans.	acei	24-28	angiotensin converting enzyme 2	Homo sapiens	55-59
32089050-2	2020	Reduced angiotensin converting enzyme 2 activity from the counter angiotensin converting enzyme 2 /angiotensin-(1-7)/Mas receptor axis of the renin angiotensin aldosterone system has been reported in people with pre-hypertension, type 2 diabetes mellitus and chronic renal disease.	Aldosterone	160-171	angiotensin converting enzyme 2	Homo sapiens	8-39
32089050-2	2020	Reduced angiotensin converting enzyme 2 activity from the counter angiotensin converting enzyme 2 /angiotensin-(1-7)/Mas receptor axis of the renin angiotensin aldosterone system has been reported in people with pre-hypertension, type 2 diabetes mellitus and chronic renal disease.	Aldosterone	160-171	angiotensin converting enzyme 2	Homo sapiens	66-97
32957797-6	2020	SARS-CoV2-induced downregulation of ACE2 expression might reduce dopamine and serotonin synthesis, causing hypodopaminergia.	Dopamine	65-73	angiotensin converting enzyme 2	Homo sapiens	36-40
32957797-6	2020	SARS-CoV2-induced downregulation of ACE2 expression might reduce dopamine and serotonin synthesis, causing hypodopaminergia.	Serotonin	78-87	angiotensin converting enzyme 2	Homo sapiens	36-40
33052306-0	2020	Comparative docking studies to understand the binding affinity of nicotine with soluble ACE2 (sACE2)-SARS-CoV-2 complex over sACE2.	Nicotine	66-74	angiotensin converting enzyme 2	Homo sapiens	88-92
31131896-12	2019	Conversely, the increase of ACE2 generating high levels of Ang 1-7, a vasodilator peptide, suggesting that this peptide can induce glucose uptake and protect cells against oxidative stress, which can elicit insulin resistance.	Glucose	131-138	angiotensin converting enzyme 2	Homo sapiens	28-32
32984543-4	2020	There is clear evidence that, by targeting the angiotensin-converting enzyme II (ACE2) -its natural receptor-, SARS-CoV-2 would mainly affect the renin-angiotensin-aldosterone system (RAAS), whose imbalance triggers diverse symptomatology-associated pathological processes.	Aldosterone	164-175	angiotensin converting enzyme 2	Homo sapiens	81-85
31141400-2	2019	Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG II to generate ANG(1-7) peptide, which counteracts the adverse effects of ANG II accumulation.	Angiotensin II	162-168	angiotensin converting enzyme 2	Homo sapiens	37-68
31323221-1	2019	The aim of this study was to explore the relationship between serum soluble angiotensin converting enzyme 2 (sACE2), parameters of cardiopulmonary exercise testing and plasma asymmetric dimethylarginine (ADMA), a marker of oxidative stress-induced endothelial dysfunction.	dimethylarginine	186-202	angiotensin converting enzyme 2	Homo sapiens	76-107
31323221-1	2019	The aim of this study was to explore the relationship between serum soluble angiotensin converting enzyme 2 (sACE2), parameters of cardiopulmonary exercise testing and plasma asymmetric dimethylarginine (ADMA), a marker of oxidative stress-induced endothelial dysfunction.	N,N-dimethylarginine	204-208	angiotensin converting enzyme 2	Homo sapiens	76-107
31430320-4	2019	Angiotensin I-converting enzymes, ACE and ACE2, are key regulators of blood pressure that have counterbalance roles by acting on vasoactive peptides from Renin-Angiotensin-Aldosterone System (RAAS).	Aldosterone	172-183	angiotensin converting enzyme 2	Homo sapiens	42-46
31141400-2	2019	Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG II to generate ANG(1-7) peptide, which counteracts the adverse effects of ANG II accumulation.	Angiotensin II	84-90	angiotensin converting enzyme 2	Homo sapiens	37-68
31141400-2	2019	Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG II to generate ANG(1-7) peptide, which counteracts the adverse effects of ANG II accumulation.	Angiotensin II	84-90	angiotensin converting enzyme 2	Homo sapiens	70-74
31141400-2	2019	Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG II to generate ANG(1-7) peptide, which counteracts the adverse effects of ANG II accumulation.	Angiotensin II	162-168	angiotensin converting enzyme 2	Homo sapiens	70-74
31141400-2	2019	Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG II to generate ANG(1-7) peptide, which counteracts the adverse effects of ANG II accumulation.	Peptides	112-119	angiotensin converting enzyme 2	Homo sapiens	37-68
31141400-2	2019	Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG II to generate ANG(1-7) peptide, which counteracts the adverse effects of ANG II accumulation.	Peptides	112-119	angiotensin converting enzyme 2	Homo sapiens	70-74
30246378-11	2019	Ang-(1-7) shifted the balance of RAS toward the ACE2/Ang-(1-7)/Mas axis, inhibited arecoline-induced ROS and NLRP3 inflammasome activation, leading to attenuation of migration or collagen synthesis.	Arecoline	83-92	angiotensin converting enzyme 2	Homo sapiens	48-52
31165585-0	2019	Both aldosterone and spironolactone can modulate the intracellular ACE/ANG II/AT1 and ACE2/ANG (1-7)/MAS receptor axes in human mesangial cells.	Aldosterone	5-16	angiotensin converting enzyme 2	Homo sapiens	86-90
31165585-0	2019	Both aldosterone and spironolactone can modulate the intracellular ACE/ANG II/AT1 and ACE2/ANG (1-7)/MAS receptor axes in human mesangial cells.	Spironolactone	21-35	angiotensin converting enzyme 2	Homo sapiens	86-90
31254308-3	2019	Equilibrium concentrations of renin angiotensin aldosterone system (RAAS) APs differ in dogs with heart disease compared to healthy dogs and recombinant human ACE2 (rhACE2) alters relative concentrations of APs.	angiotensin aldosterone	36-59	angiotensin converting enzyme 2	Homo sapiens	159-163
31254308-3	2019	Equilibrium concentrations of renin angiotensin aldosterone system (RAAS) APs differ in dogs with heart disease compared to healthy dogs and recombinant human ACE2 (rhACE2) alters relative concentrations of APs.	rhace2	165-171	angiotensin converting enzyme 2	Homo sapiens	159-163
30443713-4	2019	Therefore it is of no surprise that animals with genetic alterations in the expression of ACE2 develop a diverse pattern of phenotypes ranging from hypertension, metabolic and behavioural dysfunctions, to impairments in serotonin synthesis and neurogenesis.	Serotonin	220-229	angiotensin converting enzyme 2	Homo sapiens	90-94
30246378-11	2019	Ang-(1-7) shifted the balance of RAS toward the ACE2/Ang-(1-7)/Mas axis, inhibited arecoline-induced ROS and NLRP3 inflammasome activation, leading to attenuation of migration or collagen synthesis.	Reactive Oxygen Species	101-104	angiotensin converting enzyme 2	Homo sapiens	48-52
30335025-7	2018	We found that the ACE2 activity level was negatively correlated with body mass index (BMI), DBP, and pulse pressure, and significantly positively with ACE2 concentration, blood glucose and estrogen level in female EH patients.	Blood Glucose	171-184	angiotensin converting enzyme 2	Homo sapiens	18-22
30326474-7	2019	Effects of uremic toxins indoxyl sulphate, p-cresol and p-cresyl sulphate on ACE2 and miR-421 levels were investigated in THP-1 monocytes.	4-cresol sulfate	56-73	angiotensin converting enzyme 2	Homo sapiens	77-81
30326474-17	2019	A strong association of circulating miR-421 with decreased transcripts of ACE2 may contribute to the low expression of the enzyme in leukocytes of CKD patients, further supporting the development of atherosclerotic events.	mir-421	36-43	angiotensin converting enzyme 2	Homo sapiens	74-78
30759273-11	2019	PIc prevented the degradation of ACE-2 and restored 50% of ACE-2 activity (p < 0.05).	pic	0-3	angiotensin converting enzyme 2	Homo sapiens	33-38
30759273-11	2019	PIc prevented the degradation of ACE-2 and restored 50% of ACE-2 activity (p < 0.05).	pic	0-3	angiotensin converting enzyme 2	Homo sapiens	59-64
28992224-10	2018	Results: Leucocytes obtained from patients treated with HCO or MCO demonstrated decreased transcript expression of ACE, while ACE2 was significantly upregulated as compared with HF.	hco	56-59	angiotensin converting enzyme 2	Homo sapiens	126-130
29766392-0	2018	Excessive Glutamate Stimulation Impairs ACE2 Activity Through ADAM17-Mediated Shedding in Cultured Cortical Neurons.	Glutamic Acid	10-19	angiotensin converting enzyme 2	Homo sapiens	40-44
29766392-2	2018	In this study, we identified the role of excessive glutamate stimulation in the modulation of angiotensin-converting enzyme type 2 (ACE2), a critical component in the compensatory axis of the renin-angiotensin system (RAS).	Glutamic Acid	51-60	angiotensin converting enzyme 2	Homo sapiens	94-130
29766392-2	2018	In this study, we identified the role of excessive glutamate stimulation in the modulation of angiotensin-converting enzyme type 2 (ACE2), a critical component in the compensatory axis of the renin-angiotensin system (RAS).	Glutamic Acid	51-60	angiotensin converting enzyme 2	Homo sapiens	132-136
29766392-3	2018	In primary cultured cortical neurons, high concentration of glutamate (100 microM) significantly reduced the enzymatic activity of ACE2.	Glutamic Acid	60-69	angiotensin converting enzyme 2	Homo sapiens	131-135
29766392-4	2018	The elevated activity of ADAM17, a member of the "A Disintegrin And Metalloprotease" (ADAM) family, was found to contribute to this glutamate-induced ACE2 down-regulation.	Glutamic Acid	132-141	angiotensin converting enzyme 2	Homo sapiens	150-154
29766392-6	2018	In addition, the glutamate-induced decrease in ACE2 activity was significantly attenuated when the neurons were co-treated with MitoTEMPOL or blockers that target oxidative stress-mediated signaling pathway.	Glutamic Acid	17-26	angiotensin converting enzyme 2	Homo sapiens	47-51
29766392-6	2018	In addition, the glutamate-induced decrease in ACE2 activity was significantly attenuated when the neurons were co-treated with MitoTEMPOL or blockers that target oxidative stress-mediated signaling pathway.	MitoTEMPOL	128-138	angiotensin converting enzyme 2	Homo sapiens	47-51
29766392-7	2018	In summary, our study reveals a strong relationship between excessive glutamate stimulation and ADAM17-mediated impairment in ACE2 activity, suggesting a possible cross-talk between glutamate-induced excitotoxicity and dysregulated RAS.	Glutamic Acid	70-79	angiotensin converting enzyme 2	Homo sapiens	126-130
29766392-7	2018	In summary, our study reveals a strong relationship between excessive glutamate stimulation and ADAM17-mediated impairment in ACE2 activity, suggesting a possible cross-talk between glutamate-induced excitotoxicity and dysregulated RAS.	Glutamic Acid	182-191	angiotensin converting enzyme 2	Homo sapiens	126-130
29995907-0	2018	Propofol prevents human umbilical vein endothelial cell injury from Ang II-induced apoptosis by activating the ACE2-(1-7)-Mas axis and eNOS phosphorylation.	Propofol	0-8	angiotensin converting enzyme 2	Homo sapiens	111-115
29995907-6	2018	We examined the expression of ACE2, Ang (1-7) and Mas and found that the ACE2-Ang (1-7)-Mas axis was up-regulated by propofol, while ACE2 overexpression increased phosphorylated endothelial nitric oxide synthase (phosphorylated eNOS) expression and siACE2 resulted in the repression of endothelial nitric oxide synthase (eNOS) phosphorylation.	Propofol	117-125	angiotensin converting enzyme 2	Homo sapiens	73-77
29995907-6	2018	We examined the expression of ACE2, Ang (1-7) and Mas and found that the ACE2-Ang (1-7)-Mas axis was up-regulated by propofol, while ACE2 overexpression increased phosphorylated endothelial nitric oxide synthase (phosphorylated eNOS) expression and siACE2 resulted in the repression of endothelial nitric oxide synthase (eNOS) phosphorylation.	Propofol	117-125	angiotensin converting enzyme 2	Homo sapiens	73-77
29995907-7	2018	In conclusion, our study revealed that propofol can inhibit endothelial cell apoptosis induced by Ang II by activating the ACE2-Ang (1-7)-Mas axis and further up-regulating the expression and phosphorylation of eNOS.	Propofol	39-47	angiotensin converting enzyme 2	Homo sapiens	123-127
29977014-3	2018	Diminazene aceturate (DIZE), a small molecule drug approved by the US Food and Drug Administration, which is used to treat human trypanosomiasis, has been shown to have antifibrotic properties by enhancing ACE2 activity.	diminazene aceturate	0-20	angiotensin converting enzyme 2	Homo sapiens	206-210
29977014-3	2018	Diminazene aceturate (DIZE), a small molecule drug approved by the US Food and Drug Administration, which is used to treat human trypanosomiasis, has been shown to have antifibrotic properties by enhancing ACE2 activity.	diminazene aceturate	22-26	angiotensin converting enzyme 2	Homo sapiens	206-210
28895159-9	2018	Univariate linear regression analysis revealed that circulating ACE2 levels were positively associated with systolic blood pressure (P=.02), mean arterial pressure (P=.02) and serum creatinine (P&lt;.001) in females whereas circulating ACE2 levels were positively associated with age (P&lt;.001) and serum creatinine (P&lt;.001) in males.	Creatinine	182-192	angiotensin converting enzyme 2	Homo sapiens	64-68
28895159-9	2018	Univariate linear regression analysis revealed that circulating ACE2 levels were positively associated with systolic blood pressure (P=.02), mean arterial pressure (P=.02) and serum creatinine (P&lt;.001) in females whereas circulating ACE2 levels were positively associated with age (P&lt;.001) and serum creatinine (P&lt;.001) in males.	Creatinine	306-316	angiotensin converting enzyme 2	Homo sapiens	64-68
29363860-0	2018	ACE2-EPC-EXs protect ageing ECs against hypoxia/reoxygenation-induced injury through the miR-18a/Nox2/ROS pathway.	ros	102-105	angiotensin converting enzyme 2	Homo sapiens	0-4
29903860-7	2018	GSK2586881 infusion was associated with reduced plasma markers of inflammation within 2-4 h and increased SOD2 plasma protein at 2 weeks.PAH is characterised by reduced ACE2 activity.	gsk2586881	0-10	angiotensin converting enzyme 2	Homo sapiens	169-173
29288933-7	2018	More recent studies favor the development of targeting the downstream ACE2/Ang (1-7)/Mas receptor pathway, in which diminazene aceturate, an ACE2 activator, GSK2586881, a recombinant ACE2, and AV0991, a Mas receptor agonist, showed much potential for further development.	diminazene aceturate	116-136	angiotensin converting enzyme 2	Homo sapiens	70-74
29731719-8	2018	ACE2 or vehicle was administered via osmotic pump for the final 2 weeks, beginning 3 weeks after bleomycin.	Bleomycin	97-106	angiotensin converting enzyme 2	Homo sapiens	0-4
29731719-13	2018	Conclusion: Collectively, our findings enumerate that ACE2 treatment improved pulmonary vascular muscularization following bleomycin exposure, concomitant with increased SOD2 expression.	Bleomycin	123-132	angiotensin converting enzyme 2	Homo sapiens	54-58
28992224-13	2018	As a complementary finding, treatment with HCO and MCO in vitro dialysates induced a pro-inflammatory response of the cells as demonstrated by elevated messenger RNA expression of tumour necrosis factor alpha and interleukin-6, as well as upregulation of ACE and decreased levels of ACE2.	hco	43-46	angiotensin converting enzyme 2	Homo sapiens	283-287
28992224-13	2018	As a complementary finding, treatment with HCO and MCO in vitro dialysates induced a pro-inflammatory response of the cells as demonstrated by elevated messenger RNA expression of tumour necrosis factor alpha and interleukin-6, as well as upregulation of ACE and decreased levels of ACE2.	mco	51-54	angiotensin converting enzyme 2	Homo sapiens	283-287
31966466-0	2017	Interactions between angiotensin-converting enzyme-2 polymorphisms and high salt intake increase the risk of hypertension in the Chinese Wa population.	Salts	76-80	angiotensin converting enzyme 2	Homo sapiens	21-52
28935757-10	2017	Upregulation of ACE2 in human aortic smooth muscle cells by resveratrol in vitro was sirtuin 1-dependent.	Resveratrol	60-71	angiotensin converting enzyme 2	Homo sapiens	16-20
31966466-1	2017	Interactions between angiotensin-converting enzyme-2 (ACE2) gene polymorphisms and high salt intake increase the risk of hypertension (HTN); however, this association is not well-established in the Chinese Wa population.	Salts	88-92	angiotensin converting enzyme 2	Homo sapiens	21-52
31966466-1	2017	Interactions between angiotensin-converting enzyme-2 (ACE2) gene polymorphisms and high salt intake increase the risk of hypertension (HTN); however, this association is not well-established in the Chinese Wa population.	Salts	88-92	angiotensin converting enzyme 2	Homo sapiens	54-58
31966466-9	2017	Moreover, high salt intake increased the occurrence of hypertension among ACE2 rs2285666 TT and rs714205 GG individuals.	Salts	15-19	angiotensin converting enzyme 2	Homo sapiens	74-78
31966466-10	2017	In this study, we not only identified an association between ACE2 gene polymorphism and HTN in the Chinese Wa population, but also a possible link interaction between ACE2 polymorphism type and high salt intake in increasing the risk of HTN in this population.	Salts	199-203	angiotensin converting enzyme 2	Homo sapiens	61-65
31966466-10	2017	In this study, we not only identified an association between ACE2 gene polymorphism and HTN in the Chinese Wa population, but also a possible link interaction between ACE2 polymorphism type and high salt intake in increasing the risk of HTN in this population.	Salts	199-203	angiotensin converting enzyme 2	Homo sapiens	167-171
27806985-2	2016	Although the contribution of pancreatic ACE2 to glucose regulation has been demonstrated in genetic models of diabetes and in models with overexpression of the renin-angiotensin system (RAS), it is unclear whether islet ACE2 is involved in glycemic control in common models of human Type 2 diabetes.	Glucose	48-55	angiotensin converting enzyme 2	Homo sapiens	40-44
28944831-7	2017	Results from reverse transcription-quantitative polymerase chain reaction, western blotting and ELISA analysis demonstrated that calcitriol also modulated the expression of members of the renin-angiotensin system (RAS), including angiotensin (Ang) I-converting enzymes (ACE and ACE2), renin and Ang II, which indicates that calcitriol may exert protective effects on LPS-induced lung injury, at least partially, by regulating the balance between the expression of members of the RAS.	Calcitriol	129-139	angiotensin converting enzyme 2	Homo sapiens	278-282
29066981-6	2017	Application of NaHS, an H2S donor considerably attenuated the severity of atherosclerosis with upregulating carotid expression of ACE2, thus converting pro-atherosclerotic angiotensin II (Ang II) to anti-atherosclerotic angiotensin 1-7 (Ang-(1-7)).	sodium bisulfide	15-19	angiotensin converting enzyme 2	Homo sapiens	130-134
29066981-6	2017	Application of NaHS, an H2S donor considerably attenuated the severity of atherosclerosis with upregulating carotid expression of ACE2, thus converting pro-atherosclerotic angiotensin II (Ang II) to anti-atherosclerotic angiotensin 1-7 (Ang-(1-7)).	Hydrogen Sulfide	24-27	angiotensin converting enzyme 2	Homo sapiens	130-134
28877748-2	2017	We postulated that repleting ACE2 using GSK2586881, a recombinant form of human angiotensin-converting enzyme 2 (rhACE2), could attenuate acute lung injury.	gsk2586881	40-50	angiotensin converting enzyme 2	Homo sapiens	29-33
28877748-2	2017	We postulated that repleting ACE2 using GSK2586881, a recombinant form of human angiotensin-converting enzyme 2 (rhACE2), could attenuate acute lung injury.	gsk2586881	40-50	angiotensin converting enzyme 2	Homo sapiens	80-111
28440441-3	2017	Methylation of 5 CpG dinucleotides in the ACE2 promoter was quantified using bisulfite pyrosequencing.	Dinucleoside Phosphates	21-34	angiotensin converting enzyme 2	Homo sapiens	42-46
28440441-3	2017	Methylation of 5 CpG dinucleotides in the ACE2 promoter was quantified using bisulfite pyrosequencing.	hydrogen sulfite	77-86	angiotensin converting enzyme 2	Homo sapiens	42-46
27722772-2	2017	The renin-angiotensin system plays a key role in LVH, and since olmesartan increases plasma angiotensin-(1-7) through an increase in angiotensin-converting enzyme-related carboxypeptidase (ACE2) expression, it was hypothesized to reduce LVH, unlike other angiotensin II receptor blockers (ARBs).	olmesartan	64-74	angiotensin converting enzyme 2	Homo sapiens	189-193
27889958-0	2017	ACE2 and the Homolog Collectrin in the Modulation of Nitric Oxide and Oxidative Stress in Blood Pressure Homeostasis and Vascular Injury.	Nitric Oxide	53-65	angiotensin converting enzyme 2	Homo sapiens	0-4
27889958-4	2017	Recent Advances: Activation of the ACE2/Ang-(1-7)/Mas receptor axis reduces hypertension and improves vascular injury mainly through an increased nitric oxide (NO) bioavailability and decreased reactive oxygen species production.	Nitric Oxide	146-158	angiotensin converting enzyme 2	Homo sapiens	35-39
27889958-4	2017	Recent Advances: Activation of the ACE2/Ang-(1-7)/Mas receptor axis reduces hypertension and improves vascular injury mainly through an increased nitric oxide (NO) bioavailability and decreased reactive oxygen species production.	Reactive Oxygen Species	194-217	angiotensin converting enzyme 2	Homo sapiens	35-39
28624211-7	2017	Finally, formulation of this ACE2 cmRNA in tailor-made lipidoid nanoparticles and in lipid nanoparticles led to liver- and lung-targeted translation of significant amounts of ACE2 protein, respectively.	lipidoid	55-63	angiotensin converting enzyme 2	Homo sapiens	29-33
28624211-7	2017	Finally, formulation of this ACE2 cmRNA in tailor-made lipidoid nanoparticles and in lipid nanoparticles led to liver- and lung-targeted translation of significant amounts of ACE2 protein, respectively.	lipidoid	55-63	angiotensin converting enzyme 2	Homo sapiens	175-179
29441892-7	2017	In addition, the genotype frequencies of SNP rs6632677 in ACE2 in the structural AF male patients vs male controls were as follows: GG, 70.5 vs 83.1%; CG 26.3 vs 15.6%; and CC 3.2 vs 1.3% (P=0.029).	cysteinylglycine	151-153	angiotensin converting enzyme 2	Homo sapiens	58-62
27063099-0	2016	Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry.	Calcium	104-111	angiotensin converting enzyme 2	Homo sapiens	18-22
27638906-5	2016	The results showed that either MG132 or G100S SP-C mutation activated all three canonical pathways of the UPR (IRE1/XBP1, ATF6, and PERK/eIF2alpha), which led to a significant increase in cathepsin D or in TACE (an ACE-2 ectodomain shedding enzyme) and eventually caused AEC apoptosis.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	31-36	angiotensin converting enzyme 2	Homo sapiens	215-220
27775793-0	2016	microRNA-125b contributes to high glucose-induced reactive oxygen species generation and apoptosis in HK-2 renal tubular epithelial cells by targeting angiotensin-converting enzyme 2.	Glucose	34-41	angiotensin converting enzyme 2	Homo sapiens	151-182
27775793-5	2016	Gain- and loss-of-function experiments were performed to determine the biological roles of the ACE2-targeting microRNAs in high glucose-induced damage to renal tubular epithelial cells.	Glucose	128-135	angiotensin converting enzyme 2	Homo sapiens	95-99
27775793-7	2016	After high glucose treatment, HK-2 renal tubular epithelial cells showed an upregulation of miR-125b and reduction of ACE2 expression.	Glucose	11-18	angiotensin converting enzyme 2	Homo sapiens	118-122
27460845-0	2016	ACE2 overexpression inhibits acquired platinum resistance-induced tumor angiogenesis in NSCLC.	Platinum	38-46	angiotensin converting enzyme 2	Homo sapiens	0-4
27460845-4	2016	In the present study, we investigated the effect of ACE2 on tumor-associated angiogen-esis after the development of acquired platinum resistance in non-small cell lung cancer (NSCLC).	Platinum	125-133	angiotensin converting enzyme 2	Homo sapiens	52-56
27460845-7	2016	These platinum-resistant cells showed significantly higher angiotensin II type 1 receptor (AT1R), ACE and VEGF production and lower ACE2 expression than their corresponding parent cells.	Platinum	6-14	angiotensin converting enzyme 2	Homo sapiens	132-136
27460845-11	2016	Our findings indicate that ACE2 overexpression may potentially suppress angiogenesis in NSCLC after the development of acquired platinum resistance.	Platinum	128-136	angiotensin converting enzyme 2	Homo sapiens	27-31
27121444-4	2016	The achieved changes in BP were analyzed for their association with genotypes at ACE2 gene loci.	Benzo(a)pyrene	24-26	angiotensin converting enzyme 2	Homo sapiens	81-85
27775793-8	2016	Knockdown of miR-125b with anti-miR-125b inhibitors significantly prevented high glucose-induced downregulation of ACE2 in HK-2 cells.	mir-125b	13-21	angiotensin converting enzyme 2	Homo sapiens	115-119
27775793-8	2016	Knockdown of miR-125b with anti-miR-125b inhibitors significantly prevented high glucose-induced downregulation of ACE2 in HK-2 cells.	mir-125b	32-40	angiotensin converting enzyme 2	Homo sapiens	115-119
27775793-8	2016	Knockdown of miR-125b with anti-miR-125b inhibitors significantly prevented high glucose-induced downregulation of ACE2 in HK-2 cells.	Glucose	81-88	angiotensin converting enzyme 2	Homo sapiens	115-119
27775793-11	2016	Rescue experiments demonstrated that overexpression of ACE2 reversed the effects of miR-125b on ROS generation, apoptosis, and deregulation of Bcl-2 and Bax in HK-2 cells.	mir-125b	84-92	angiotensin converting enzyme 2	Homo sapiens	55-59
27775793-11	2016	Rescue experiments demonstrated that overexpression of ACE2 reversed the effects of miR-125b on ROS generation, apoptosis, and deregulation of Bcl-2 and Bax in HK-2 cells.	Reactive Oxygen Species	96-99	angiotensin converting enzyme 2	Homo sapiens	55-59
27775793-12	2016	CONCLUSIONS: Taken together, miR-125b mediates high glucose-induced ROS production and apoptosis in HK-2 renal tubular epithelial cells, largely through targeting ACE2.	mir-125b	29-37	angiotensin converting enzyme 2	Homo sapiens	163-167
27775793-12	2016	CONCLUSIONS: Taken together, miR-125b mediates high glucose-induced ROS production and apoptosis in HK-2 renal tubular epithelial cells, largely through targeting ACE2.	Glucose	52-59	angiotensin converting enzyme 2	Homo sapiens	163-167
27775793-12	2016	CONCLUSIONS: Taken together, miR-125b mediates high glucose-induced ROS production and apoptosis in HK-2 renal tubular epithelial cells, largely through targeting ACE2.	Reactive Oxygen Species	68-71	angiotensin converting enzyme 2	Homo sapiens	163-167
27367913-3	2016	This review focuses on experimental studies that have used the off-target effects of the antitrypanosomal agent, diminazene aceturate (DIZE) to activate ACE2.	diminazene aceturate	113-133	angiotensin converting enzyme 2	Homo sapiens	153-157
27367913-3	2016	This review focuses on experimental studies that have used the off-target effects of the antitrypanosomal agent, diminazene aceturate (DIZE) to activate ACE2.	diminazene aceturate	135-139	angiotensin converting enzyme 2	Homo sapiens	153-157
27217402-0	2016	Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.	[Pyr1]-Apelin-13	70-83	angiotensin converting enzyme 2	Homo sapiens	0-31
27217402-8	2016	The biological relevance of ACE2-mediated proteolytic processing of apelin peptides was further supported by the reduced potency of pyr-apelin 12 and apelin 16 on the activation of signaling pathways and nitric oxide production from endothelial cells.	Nitric Oxide	204-216	angiotensin converting enzyme 2	Homo sapiens	28-32
27063099-7	2016	Mechanistically, ACE2/Ang-(1-7)/Mas axis activation inhibits store-operated calcium entry (SOCE) and PAK1/NF-kappaB/Snail1 pathways, and induces E-cadherin expression.	Calcium	76-83	angiotensin converting enzyme 2	Homo sapiens	17-21
26883384-6	2016	In vitro, Ang-(1-7)/ACE2 ameliorated hepatic steatosis, oxidative stress and inflammation in free fatty acid (FFA)-induced HepG2 cells, and what"s more, Akt inhibitors reduced ACE2-mediated lipid metabolism.	Fatty Acids, Nonesterified	93-108	angiotensin converting enzyme 2	Homo sapiens	20-24
26883384-6	2016	In vitro, Ang-(1-7)/ACE2 ameliorated hepatic steatosis, oxidative stress and inflammation in free fatty acid (FFA)-induced HepG2 cells, and what"s more, Akt inhibitors reduced ACE2-mediated lipid metabolism.	Fatty Acids, Nonesterified	110-113	angiotensin converting enzyme 2	Homo sapiens	20-24
26862037-4	2016	We investigated whether diminazene aceturate (DIZE), an angiotensin-converting enzyme 2 (ACE2) activator, prevented lipopolysaccharide (LPS)-induced inflammatory response by activating the protective axis and whether the effect was mediated by inhibiting the mitogen-activated protein kinase (MAPK) and the nuclear factor-kappaB (NF-kappaB) pathways.	diminazene aceturate	24-44	angiotensin converting enzyme 2	Homo sapiens	56-87
26562171-3	2016	Our aim was to investigate the effect of estradiol (E2) on angiotensin converting enzymes (ACE) 1 and ACE2 expression and activities in human endothelial cells (HUVEC), and the role of estrogen receptors (ER).	Estradiol	41-50	angiotensin converting enzyme 2	Homo sapiens	102-106
26862037-4	2016	We investigated whether diminazene aceturate (DIZE), an angiotensin-converting enzyme 2 (ACE2) activator, prevented lipopolysaccharide (LPS)-induced inflammatory response by activating the protective axis and whether the effect was mediated by inhibiting the mitogen-activated protein kinase (MAPK) and the nuclear factor-kappaB (NF-kappaB) pathways.	diminazene aceturate	24-44	angiotensin converting enzyme 2	Homo sapiens	89-93
26862037-0	2016	Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-kappaB pathways in human retinal pigment epithelium.	diminazene aceturate	42-62	angiotensin converting enzyme 2	Homo sapiens	0-31
26862037-4	2016	We investigated whether diminazene aceturate (DIZE), an angiotensin-converting enzyme 2 (ACE2) activator, prevented lipopolysaccharide (LPS)-induced inflammatory response by activating the protective axis and whether the effect was mediated by inhibiting the mitogen-activated protein kinase (MAPK) and the nuclear factor-kappaB (NF-kappaB) pathways.	diminazene aceturate	46-50	angiotensin converting enzyme 2	Homo sapiens	56-87
26862037-4	2016	We investigated whether diminazene aceturate (DIZE), an angiotensin-converting enzyme 2 (ACE2) activator, prevented lipopolysaccharide (LPS)-induced inflammatory response by activating the protective axis and whether the effect was mediated by inhibiting the mitogen-activated protein kinase (MAPK) and the nuclear factor-kappaB (NF-kappaB) pathways.	diminazene aceturate	46-50	angiotensin converting enzyme 2	Homo sapiens	89-93
26386115-10	2015	In the presence of Ang II, XNT or DIZE enhanced proliferation and migration that were blocked by DX-600, an ACE2 inhibitor.	dx-600	97-103	angiotensin converting enzyme 2	Homo sapiens	108-112
26679819-1	2015	Many studies identified new components of the renin-angiotensin system (RAS), such as Angiotensin-(1-7) [Ang-(1-7)] and Angiotensin-converting enzyme type 2 (ACE2), in mammalian ovaries.We previously showed Angiotensin-Converting Enzyme (ACE) inhibition, which increases the level of Ang-(1-7), stimulated ovarian estradiol output in ewe after estrous synchronization.	Estradiol	314-323	angiotensin converting enzyme 2	Homo sapiens	158-162
26163449-9	2015	Activation of AT2 with agonist CGP or with ANG II under concomitant AT1 antagonist reduced TNF-alpha-induced ICAM-1 expression, which was reversed by AT2 antagonist PD or ACE2 inhibitor DX600 or knockdown of ACE2 with small interfering RNA.	dx600	186-191	angiotensin converting enzyme 2	Homo sapiens	171-175
26195630-7	2015	Furthermore, when C-terminally fused to an ACE2 transmembrane anchor, the secretory N-terminal catalytic or hinge-cysteine-histidine-rich domain domains of PCSK9 were able to reduce CD81 and LDLR levels.	Cysteine	114-122	angiotensin converting enzyme 2	Homo sapiens	43-47
26195630-7	2015	Furthermore, when C-terminally fused to an ACE2 transmembrane anchor, the secretory N-terminal catalytic or hinge-cysteine-histidine-rich domain domains of PCSK9 were able to reduce CD81 and LDLR levels.	Histidine	123-132	angiotensin converting enzyme 2	Homo sapiens	43-47
26239661-5	2015	Additionally, baicalin significantly conversed Ang II to angiotensin-1-7 [Ang-(1-7)] by activating angiotensin-converting enzyme 2 (ACE2) and Mas receptor mRNA expression and protein expression.	baicalin	14-22	angiotensin converting enzyme 2	Homo sapiens	99-130
26239661-5	2015	Additionally, baicalin significantly conversed Ang II to angiotensin-1-7 [Ang-(1-7)] by activating angiotensin-converting enzyme 2 (ACE2) and Mas receptor mRNA expression and protein expression.	baicalin	14-22	angiotensin converting enzyme 2	Homo sapiens	132-136
25665060-9	2015	TAPI-2, an inhibitor of TNF-alpha-converting enzyme (TACE/ADAM17), prevented both the decrease in cellular ACE-2 and the increase in soluble ACE-2 (both P &lt; 0.05).	TAPI-2	0-6	angiotensin converting enzyme 2	Homo sapiens	107-112
26275770-6	2015	The ACE2/Ang-(1-7)/MasR and ACE2/Ang-(1-9)/AT2R axes have opposite effects to those of the ACE/Ang II/AT1R axis, such as decreased proliferation and cardiovascular remodeling, increased production of nitric oxide and vasodilation.	Nitric Oxide	200-212	angiotensin converting enzyme 2	Homo sapiens	4-8
26275770-6	2015	The ACE2/Ang-(1-7)/MasR and ACE2/Ang-(1-9)/AT2R axes have opposite effects to those of the ACE/Ang II/AT1R axis, such as decreased proliferation and cardiovascular remodeling, increased production of nitric oxide and vasodilation.	Nitric Oxide	200-212	angiotensin converting enzyme 2	Homo sapiens	28-32
25813276-3	2015	METHODS: Circulating ACE2 activity was measured in human ethylenediamine-tetraacetic acid (EDTA)-plasma samples from the NEFRONA study (n = 2572): control group (CONT) (n = 568), CKD3-5 (n = 1458) and CKD5D (n = 546).	Edetic Acid	57-89	angiotensin converting enzyme 2	Homo sapiens	21-25
25813276-3	2015	METHODS: Circulating ACE2 activity was measured in human ethylenediamine-tetraacetic acid (EDTA)-plasma samples from the NEFRONA study (n = 2572): control group (CONT) (n = 568), CKD3-5 (n = 1458) and CKD5D (n = 546).	Edetic Acid	91-95	angiotensin converting enzyme 2	Homo sapiens	21-25
25813276-12	2015	CONCLUSIONS: Circulating ACE2 and ACE activities can be measured in human EDTA-plasma samples with zinc added to recover enzymatic activity.	Edetic Acid	74-78	angiotensin converting enzyme 2	Homo sapiens	25-29
25813276-13	2015	In a CKD population without previous history of CV disease, ACE2 activity from human EDTA-plasma samples directly correlated with the classical CV risk factors namely older age, diabetes and male gender.	Edetic Acid	85-89	angiotensin converting enzyme 2	Homo sapiens	60-64
25665060-9	2015	TAPI-2, an inhibitor of TNF-alpha-converting enzyme (TACE/ADAM17), prevented both the decrease in cellular ACE-2 and the increase in soluble ACE-2 (both P &lt; 0.05).	TAPI-2	0-6	angiotensin converting enzyme 2	Homo sapiens	141-146
25680080-9	2015	Central acting ACE inhibitors can be useful in the future for the management of neuropathic pain due to following actions: (i) ACE-2 converts angiotensinogen to angiotensin(1-7) (hepatapeptide) which produces neuroprotective action; (ii) ACE inhibitors downregulate kinin B1 receptors in the peripheral nervous system which is responsible for neuropathic pain.	hepatapeptide	179-192	angiotensin converting enzyme 2	Homo sapiens	127-132
25287898-0	2015	Urinary angiotensin-converting enzyme 2 increases in diabetic nephropathy by angiotensin II type 1 receptor blocker olmesartan.	olmesartan	116-126	angiotensin converting enzyme 2	Homo sapiens	8-39
25883526-1	2015	PURPOSE: Our previous study demonstrated that an intraperitoneal injection of Diminazene Aceturate (DIZE) attenuated uveitis by activating ocular angiotensin-converting enzyme 2 (ACE2).	diminazene aceturate	78-98	angiotensin converting enzyme 2	Homo sapiens	146-177
25883526-1	2015	PURPOSE: Our previous study demonstrated that an intraperitoneal injection of Diminazene Aceturate (DIZE) attenuated uveitis by activating ocular angiotensin-converting enzyme 2 (ACE2).	diminazene aceturate	78-98	angiotensin converting enzyme 2	Homo sapiens	179-183
25883526-1	2015	PURPOSE: Our previous study demonstrated that an intraperitoneal injection of Diminazene Aceturate (DIZE) attenuated uveitis by activating ocular angiotensin-converting enzyme 2 (ACE2).	diminazene aceturate	100-104	angiotensin converting enzyme 2	Homo sapiens	146-177
25883526-1	2015	PURPOSE: Our previous study demonstrated that an intraperitoneal injection of Diminazene Aceturate (DIZE) attenuated uveitis by activating ocular angiotensin-converting enzyme 2 (ACE2).	diminazene aceturate	100-104	angiotensin converting enzyme 2	Homo sapiens	179-183
25519733-4	2015	DOCA-salt-induced hypertension was reduced in SL mice, with hACE2 overexpression in the brain.	Desoxycorticosterone Acetate	0-4	angiotensin converting enzyme 2	Homo sapiens	60-65
25435005-0	2015	Therapeutic effect of human umbilical cord mesenchymal stem cells modified by angiotensin-converting enzyme 2 gene on bleomycin-induced lung fibrosis injury.	Bleomycin	118-127	angiotensin converting enzyme 2	Homo sapiens	78-109
25435005-1	2015	The aim of the present study was to evaluate the therapeutic effects of human umbilical cord mesenchymal stem cells (uMSCs) in the presence of angiotensin-converting enzyme 2 gene (ACE2; ACE2-uMSCs) on bleomycin (BLM)-induced lung injury and pulmonary fibrosis in mice.	Bleomycin	202-211	angiotensin converting enzyme 2	Homo sapiens	143-174
25435005-1	2015	The aim of the present study was to evaluate the therapeutic effects of human umbilical cord mesenchymal stem cells (uMSCs) in the presence of angiotensin-converting enzyme 2 gene (ACE2; ACE2-uMSCs) on bleomycin (BLM)-induced lung injury and pulmonary fibrosis in mice.	Bleomycin	202-211	angiotensin converting enzyme 2	Homo sapiens	181-185
25435005-1	2015	The aim of the present study was to evaluate the therapeutic effects of human umbilical cord mesenchymal stem cells (uMSCs) in the presence of angiotensin-converting enzyme 2 gene (ACE2; ACE2-uMSCs) on bleomycin (BLM)-induced lung injury and pulmonary fibrosis in mice.	Bleomycin	202-211	angiotensin converting enzyme 2	Homo sapiens	187-191
25435005-1	2015	The aim of the present study was to evaluate the therapeutic effects of human umbilical cord mesenchymal stem cells (uMSCs) in the presence of angiotensin-converting enzyme 2 gene (ACE2; ACE2-uMSCs) on bleomycin (BLM)-induced lung injury and pulmonary fibrosis in mice.	Bleomycin	213-216	angiotensin converting enzyme 2	Homo sapiens	143-174
25435005-1	2015	The aim of the present study was to evaluate the therapeutic effects of human umbilical cord mesenchymal stem cells (uMSCs) in the presence of angiotensin-converting enzyme 2 gene (ACE2; ACE2-uMSCs) on bleomycin (BLM)-induced lung injury and pulmonary fibrosis in mice.	Bleomycin	213-216	angiotensin converting enzyme 2	Homo sapiens	181-185
25435005-1	2015	The aim of the present study was to evaluate the therapeutic effects of human umbilical cord mesenchymal stem cells (uMSCs) in the presence of angiotensin-converting enzyme 2 gene (ACE2; ACE2-uMSCs) on bleomycin (BLM)-induced lung injury and pulmonary fibrosis in mice.	Bleomycin	213-216	angiotensin converting enzyme 2	Homo sapiens	187-191
25435005-5	2015	In addition, treatment with ACE2-uMSCs demonstrated a stronger therapeutic effect than ACE2- or uMSC treatment alone, indicated by decreased expression of MDA, GSSG, TNF-alpha, IFN-gamma, TGF-beta, IL-1, IL-2, IL-6, collagen type 1 mRNA, MMPs and TIMPs as well as hydroxyproline concentration, and upregulation of SOD, GSH and ACE2 and IL-10.	Hydroxyproline	264-278	angiotensin converting enzyme 2	Homo sapiens	28-32
25435005-5	2015	In addition, treatment with ACE2-uMSCs demonstrated a stronger therapeutic effect than ACE2- or uMSC treatment alone, indicated by decreased expression of MDA, GSSG, TNF-alpha, IFN-gamma, TGF-beta, IL-1, IL-2, IL-6, collagen type 1 mRNA, MMPs and TIMPs as well as hydroxyproline concentration, and upregulation of SOD, GSH and ACE2 and IL-10.	Glutathione	319-322	angiotensin converting enzyme 2	Homo sapiens	28-32
25435005-6	2015	In conclusion, the results of the present study demonstrated that ACE2 and uMSCs had a synergistic therapeutic effect on bleomycin-induced acute lung injury.	Bleomycin	121-130	angiotensin converting enzyme 2	Homo sapiens	66-70
25287898-2	2015	We evaluated the changes in urinary ACE2 levels in response to treatment with the angiotensin II type 1 receptor blocker olmesartan in diabetes patients with nephropathy.	olmesartan	121-131	angiotensin converting enzyme 2	Homo sapiens	36-40
25287898-5	2015	RESULTS: In diabetes patients with chronic kidney disease, olmesartan significantly increased urinary ACE2 levels independently of blood pressure and plasma aldosterone levels and reduced albuminuria, urinary liver-type fatty acid binding protein (L-FABP), and plasma aldosterone levels.	olmesartan	59-69	angiotensin converting enzyme 2	Homo sapiens	102-106
25287898-7	2015	CONCLUSION: Olmesartan may have the unique effect of increasing urinary ACE2 levels.	olmesartan	12-22	angiotensin converting enzyme 2	Homo sapiens	72-76
25688208-4	2015	In previous studies we used single beta-amino acid substitutions to modulate the structure of Ang II and its selectivity for ACE2, AT1R, and angiotensin type 2 (AT2R) receptor.	beta-amino acid	35-50	angiotensin converting enzyme 2	Homo sapiens	125-129
25423498-7	2015	CONCLUSION: Calycosin from Radix Astragali from Gansu province could protect HUVECs from AngII induced RAS disorder by downregulation of ACE expression and increased ACE2 expression, which is similar to irbesartan.	7,3'-dihydroxy-4'-methoxyisoflavone	12-21	angiotensin converting enzyme 2	Homo sapiens	166-170
25688208-1	2015	Angiotensin converting enzyme 2 (ACE2) is a zinc carboxypeptidase involved in the renin-angiotensin system (RAS) and inactivates the potent vasopressive peptide angiotensin II (Ang II) by removing the C-terminal phenylalanine residue to yield Ang1-7.	Phenylalanine	212-225	angiotensin converting enzyme 2	Homo sapiens	0-31
25688208-1	2015	Angiotensin converting enzyme 2 (ACE2) is a zinc carboxypeptidase involved in the renin-angiotensin system (RAS) and inactivates the potent vasopressive peptide angiotensin II (Ang II) by removing the C-terminal phenylalanine residue to yield Ang1-7.	Phenylalanine	212-225	angiotensin converting enzyme 2	Homo sapiens	33-37
26106051-4	2015	The synthesized mixed substrates "Nma-Xaa-Pro-Lys(Dnp)" were hydrolyzed by recombinant human (rh) ACE2.	nma-xaa	34-41	angiotensin converting enzyme 2	Homo sapiens	98-102
25089563-0	2015	The angiotensin-converting enzyme 2/angiotensin (1-7)/Mas axis protects against lung fibroblast migration and lung fibrosis by inhibiting the NOX4-derived ROS-mediated RhoA/Rho kinase pathway.	Reactive Oxygen Species	155-158	angiotensin converting enzyme 2	Homo sapiens	4-35
25089563-8	2015	Moreover, Ang(1-7) and lentivirus-mediated ACE2 (lentiACE2) suppressed AngII-induced migration and alpha-collagen I synthesis by inhibiting the NOX4-derived ROS-mediated RhoA/Rock pathway.	Reactive Oxygen Species	157-160	angiotensin converting enzyme 2	Homo sapiens	43-47
25089563-10	2015	In vivo, constant infusion with Ang(1-7) or intratracheal instillation with lenti-ACE2 shifted the RAS balance toward the ACE2/Ang(1-7)/Mas axis, alleviated bleomycin-induced lung fibrosis, and inhibited the RhoA/Rock pathway by reducing NOX4-derived ROS.	Bleomycin	157-166	angiotensin converting enzyme 2	Homo sapiens	82-86
25089563-10	2015	In vivo, constant infusion with Ang(1-7) or intratracheal instillation with lenti-ACE2 shifted the RAS balance toward the ACE2/Ang(1-7)/Mas axis, alleviated bleomycin-induced lung fibrosis, and inhibited the RhoA/Rock pathway by reducing NOX4-derived ROS.	Reactive Oxygen Species	251-254	angiotensin converting enzyme 2	Homo sapiens	82-86
25089563-11	2015	INNOVATION: This study suggests that the ACE2/Ang(1-7)/Mas axis may be targeted by novel pharmacological antioxidant strategies to treat lung fibrosis induced by AngII-mediated ROS.	Reactive Oxygen Species	177-180	angiotensin converting enzyme 2	Homo sapiens	41-45
25089563-12	2015	CONCLUSION: The ACE2/Ang(1-7)/Mas axis protects against lung fibroblast migration and lung fibrosis by inhibiting the NOX4-derived ROS-mediated RhoA/Rock pathway.	Reactive Oxygen Species	131-134	angiotensin converting enzyme 2	Homo sapiens	16-20
24842388-0	2015	Urinary angiotensin-converting enzyme 2 in hypertensive patients may be increased by olmesartan, an angiotensin II receptor blocker.	olmesartan	85-95	angiotensin converting enzyme 2	Homo sapiens	8-39
24842388-7	2015	Urinary ACE2 level was higher in the olmesartan-treated group, but not the other treatment groups, than in the control group.	olmesartan	37-47	angiotensin converting enzyme 2	Homo sapiens	8-12
24842388-8	2015	Urinary ACE2 level was positively correlated with systolic blood pressure (r = 0.211; P = 0.003), UACR (r = 0.367; P &lt; 0.001), and estimated salt intake (r = 0.260; P &lt; 0.001).	Salts	144-148	angiotensin converting enzyme 2	Homo sapiens	8-12
24842388-9	2015	Multivariable regression analysis after adjustment of age, sex, and the correlated indices showed that the use of olmesartan was an independent predictor of urinary ACE2 level.	olmesartan	114-124	angiotensin converting enzyme 2	Homo sapiens	165-169
24842388-10	2015	CONCLUSIONS: In contrast with other antihypertensive drugs, olmesartan may uniquely increase urinary ACE2 level, which could potentially offer additional renoprotective effects.	olmesartan	60-70	angiotensin converting enzyme 2	Homo sapiens	101-105
26106051-4	2015	The synthesized mixed substrates "Nma-Xaa-Pro-Lys(Dnp)" were hydrolyzed by recombinant human (rh) ACE2.	Pro-Lys	42-49	angiotensin converting enzyme 2	Homo sapiens	98-102
26106051-4	2015	The synthesized mixed substrates "Nma-Xaa-Pro-Lys(Dnp)" were hydrolyzed by recombinant human (rh) ACE2.	2,4-Dinitrophenol	50-53	angiotensin converting enzyme 2	Homo sapiens	98-102
25339158-0	2014	Counter-regulatory effects played by the ACE - Ang II - AT1 and ACE2 - Ang-(1-7) - Mas axes on the reactive oxygen species-mediated control of vascular function: perspectives to pharmacological approaches in controlling vascular complications.	Reactive Oxygen Species	99-122	angiotensin converting enzyme 2	Homo sapiens	64-68
24390175-2	2014	This in vitro study compared the direct and indirect effects of angiotensin-(1-7), the ACE1 inhibitor captopril, and diminazene aceturate (DIZE) an alleged ACE2 activator in rings of porcine coronary arteries, by measuring changes of isometric tension.	diminazene aceturate	117-137	angiotensin converting enzyme 2	Homo sapiens	156-160
25031298-10	2014	ACE2 was negatively correlated with ACE1, angiotensin I, angiotensin II, TGF-beta1, Col-IV, FN, ROS, and MDA, and positively correlated with SOD and GSH (each p &lt; 0.05).	ros	96-99	angiotensin converting enzyme 2	Homo sapiens	0-4
25031298-10	2014	ACE2 was negatively correlated with ACE1, angiotensin I, angiotensin II, TGF-beta1, Col-IV, FN, ROS, and MDA, and positively correlated with SOD and GSH (each p &lt; 0.05).	Glutathione	149-152	angiotensin converting enzyme 2	Homo sapiens	0-4
25031298-11	2014	CONCLUSION: The results suggest that ATRA acts as a positive regulator of PHB1, PHB2 and ACE2, and as a negative regulator of ACE1, angiotensin I, and angiotensin II in a RTEC model system under hypoxia/reoxygenation conditions.	Tretinoin	37-41	angiotensin converting enzyme 2	Homo sapiens	89-93
24297485-8	2014	Our present study suggests that olmesartan could block the AGEs-induced VCAM-1 gene induction in mesangial cells by restoring the downregulated ACE 2 levels and subsequently stimulating the Ang-(1-7)-Mas receptor axis.	olmesartan	32-42	angiotensin converting enzyme 2	Homo sapiens	144-149
24823497-6	2014	The purified human ACE2 converted Abeta43 to Abeta42, and this activity was inhibited by a specific ACE2 inhibitor, DX600.	dx600	116-121	angiotensin converting enzyme 2	Homo sapiens	19-23
24823497-6	2014	The purified human ACE2 converted Abeta43 to Abeta42, and this activity was inhibited by a specific ACE2 inhibitor, DX600.	dx600	116-121	angiotensin converting enzyme 2	Homo sapiens	100-104
24297485-0	2014	Olmesartan blocks advanced glycation end products-induced vcam-1 gene expression in mesangial cells by restoring Angiotensin-converting enzyme 2 level.	olmesartan	0-10	angiotensin converting enzyme 2	Homo sapiens	113-144
24297485-5	2014	AGEs significantly increased superoxide generation, upregulated RAGE mRNA level, and decreased ACE 2 gene expression and Ang-(1-7) production in mesangial cells, all of which were blocked by olmesartan, but not by a different type of ARB, azilsartan.	olmesartan	191-201	angiotensin converting enzyme 2	Homo sapiens	95-100
24297485-6	2014	An antioxidant, N-acetylcysteine or RAGE-antibodies also restored the decrease in ACE 2 mRNA level in AGEs-exposed mesangial cells.	Acetylcysteine	16-32	angiotensin converting enzyme 2	Homo sapiens	82-87
24390175-2	2014	This in vitro study compared the direct and indirect effects of angiotensin-(1-7), the ACE1 inhibitor captopril, and diminazene aceturate (DIZE) an alleged ACE2 activator in rings of porcine coronary arteries, by measuring changes of isometric tension.	diminazene aceturate	139-143	angiotensin converting enzyme 2	Homo sapiens	156-160
24168260-4	2014	We hypothesized that up-regulation of the ACE2/Ang-(1-7)/Mas axis protects against bleomycin (BLM)-induced pulmonary fibrosis by inhibiting the mitogen-activated protein kinase (MAPK)/NF-kappaB pathway.	Bleomycin	83-92	angiotensin converting enzyme 2	Homo sapiens	42-46
24168260-4	2014	We hypothesized that up-regulation of the ACE2/Ang-(1-7)/Mas axis protects against bleomycin (BLM)-induced pulmonary fibrosis by inhibiting the mitogen-activated protein kinase (MAPK)/NF-kappaB pathway.	Bleomycin	94-97	angiotensin converting enzyme 2	Homo sapiens	42-46
24227843-4	2014	Here, we show that arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for cleavage by TMPRSS2 and HAT and that ACE2 processing is required for augmentation of SARS-S-driven entry by these proteases.	Arginine	19-27	angiotensin converting enzyme 2	Homo sapiens	55-59
24147777-4	2014	In the present paper, we show, by Western blotting and qPCR (quantitative real-time PCR), that ACE2 expression is increased under conditions of cell stress, including hypoxic conditions, IL (interleukin)-1beta treatment and treatment with the AMP mimic AICAR (5-amino-4-imidazolecarboxamide riboside).	Adenosine Monophosphate	243-246	angiotensin converting enzyme 2	Homo sapiens	95-99
24147777-4	2014	In the present paper, we show, by Western blotting and qPCR (quantitative real-time PCR), that ACE2 expression is increased under conditions of cell stress, including hypoxic conditions, IL (interleukin)-1beta treatment and treatment with the AMP mimic AICAR (5-amino-4-imidazolecarboxamide riboside).	acadesine	253-258	angiotensin converting enzyme 2	Homo sapiens	95-99
24147777-4	2014	In the present paper, we show, by Western blotting and qPCR (quantitative real-time PCR), that ACE2 expression is increased under conditions of cell stress, including hypoxic conditions, IL (interleukin)-1beta treatment and treatment with the AMP mimic AICAR (5-amino-4-imidazolecarboxamide riboside).	acadesine	260-299	angiotensin converting enzyme 2	Homo sapiens	95-99
24409169-6	2014	In contrast, the non-classical RAS composed of the ACE2-Ang-(1-7)-Mas receptor axis generally opposes the actions of a stimulated Ang II-AT1R axis through an increase in nitric oxide and prostaglandins and mediates vasodilation, natriuresis, diuresis, and oxidative stress.	Nitric Oxide	170-182	angiotensin converting enzyme 2	Homo sapiens	51-55
24409169-6	2014	In contrast, the non-classical RAS composed of the ACE2-Ang-(1-7)-Mas receptor axis generally opposes the actions of a stimulated Ang II-AT1R axis through an increase in nitric oxide and prostaglandins and mediates vasodilation, natriuresis, diuresis, and oxidative stress.	Prostaglandins	187-201	angiotensin converting enzyme 2	Homo sapiens	51-55
24389733-5	2014	Alamandine is generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7).	alamandine	0-10	angiotensin converting enzyme 2	Homo sapiens	50-54
24227843-4	2014	Here, we show that arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for cleavage by TMPRSS2 and HAT and that ACE2 processing is required for augmentation of SARS-S-driven entry by these proteases.	Lysine	32-38	angiotensin converting enzyme 2	Homo sapiens	55-59
24227843-4	2014	Here, we show that arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for cleavage by TMPRSS2 and HAT and that ACE2 processing is required for augmentation of SARS-S-driven entry by these proteases.	Lysine	32-38	angiotensin converting enzyme 2	Homo sapiens	138-142
24227843-4	2014	Here, we show that arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for cleavage by TMPRSS2 and HAT and that ACE2 processing is required for augmentation of SARS-S-driven entry by these proteases.	sars-s	186-192	angiotensin converting enzyme 2	Homo sapiens	55-59
24227843-4	2014	Here, we show that arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for cleavage by TMPRSS2 and HAT and that ACE2 processing is required for augmentation of SARS-S-driven entry by these proteases.	sars-s	186-192	angiotensin converting enzyme 2	Homo sapiens	138-142
24014829-5	2013	Deoxycorticosterone acetate-salt treatment in nontransgenic mice led to significant increases in blood pressure, hypothalamic angiotensin II levels, inflammation, impaired baroreflex sensitivity, and autonomic dysfunction, as well as decreased hypothalamic ACE2 activity and expression, although these changes were blunted or prevented in syn-hACE2 mice.	Desoxycorticosterone Acetate	0-27	angiotensin converting enzyme 2	Homo sapiens	343-348
24014829-5	2013	Deoxycorticosterone acetate-salt treatment in nontransgenic mice led to significant increases in blood pressure, hypothalamic angiotensin II levels, inflammation, impaired baroreflex sensitivity, and autonomic dysfunction, as well as decreased hypothalamic ACE2 activity and expression, although these changes were blunted or prevented in syn-hACE2 mice.	Salts	28-32	angiotensin converting enzyme 2	Homo sapiens	343-348
23816468-6	2013	These changes were strikingly prevented by administration of ERK1/2 inhibitor PD98059 (10muM) and JAK/STAT inhibitor WP1066 (5 muM) but were largely aggravated by ACE2 inhibitor DX600 (0.5 muM).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	78-85	angiotensin converting enzyme 2	Homo sapiens	163-167
23816468-6	2013	These changes were strikingly prevented by administration of ERK1/2 inhibitor PD98059 (10muM) and JAK/STAT inhibitor WP1066 (5 muM) but were largely aggravated by ACE2 inhibitor DX600 (0.5 muM).	dx600	178-183	angiotensin converting enzyme 2	Homo sapiens	163-167
23816468-7	2013	More importantly, treatment with human recombinant ACE2 (hrACE2; 1mg/ml) dramatically prevented Ang II-mediated SOCS3 expression and the JAK2-STAT3 and ERK1/2 signaling, and resulted in attenuation of superoxide production and cell proliferation in HUASMCs.	Superoxides	201-211	angiotensin converting enzyme 2	Homo sapiens	51-55
23816468-9	2013	In conclusion, treatment with hrACE2 prevents Ang II-mediated activation of the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways, contributing to attenuation of superoxide generation and cell proliferation in HUASMCs, suggesting a protective mechanism of ACE2 against Ang II-mediated oxidative stress and VSMC proliferation.	Superoxides	168-178	angiotensin converting enzyme 2	Homo sapiens	32-36
23620529-9	2013	The key elements of local renal RAS, including angiotensinogen, angiotensin converting enzyme (ACE), ACE2, AT1, and AT2 receptor expression in both mRNA and protein, except renin, were altered following maternal high salt intake.	Salts	217-221	angiotensin converting enzyme 2	Homo sapiens	101-105
23624786-6	2013	TAPI-2, an inhibitor of ADAM17/TACE, significantly reduced both the activation of cathepsin D and the loss of ACE-2.	TAPI-2	0-6	angiotensin converting enzyme 2	Homo sapiens	110-115
23751363-5	2013	Actinomycin D (1 mg/ml), BQ123 (1 mumol/l), and the p38 mitogen-activated protein kinase (MAPK) siRNA and inhibitor PD169316 (25 mumol/l) completely abolished the effect of ET-1 on ACE2 expression in HBEpCs.	cyclo(Trp-Asp-Pro-Val-Leu)	25-30	angiotensin converting enzyme 2	Homo sapiens	181-185
23230080-5	2013	ACE2 expression was lower, and ACE2 activators xanthenone and diminazine aceturate were less effective in inducing the migration in cells from patients with diabetes compared with controls.	xanthone	47-57	angiotensin converting enzyme 2	Homo sapiens	31-35
23230080-5	2013	ACE2 expression was lower, and ACE2 activators xanthenone and diminazine aceturate were less effective in inducing the migration in cells from patients with diabetes compared with controls.	diminazene aceturate	62-82	angiotensin converting enzyme 2	Homo sapiens	31-35
23144053-9	2013	Urinary ACE2 concentrations appeared to correlate with HOMA-IR, fasting blood glucose, triglyceride, high-sensitivity C-reactive protein, serum creatinine, urinary ACR, and systolic blood pressure (all P&lt;0.05).	Glucose	78-85	angiotensin converting enzyme 2	Homo sapiens	8-12
23144053-9	2013	Urinary ACE2 concentrations appeared to correlate with HOMA-IR, fasting blood glucose, triglyceride, high-sensitivity C-reactive protein, serum creatinine, urinary ACR, and systolic blood pressure (all P&lt;0.05).	Triglycerides	87-99	angiotensin converting enzyme 2	Homo sapiens	8-12
23298658-11	2013	DX600, an ACE2 specific inhibitor did not cross-react with ACE.	dx600	0-5	angiotensin converting enzyme 2	Homo sapiens	10-14
23298658-18	2013	Calu-3 also demonstrated elevated ACE2 enzymatic activity in all three sources and could be inhibited by the ACE2 specific inhibitor DX600 as well as the neutralizing antibodies for the recombinant ACE2.	dx600	133-138	angiotensin converting enzyme 2	Homo sapiens	109-113
23298658-18	2013	Calu-3 also demonstrated elevated ACE2 enzymatic activity in all three sources and could be inhibited by the ACE2 specific inhibitor DX600 as well as the neutralizing antibodies for the recombinant ACE2.	dx600	133-138	angiotensin converting enzyme 2	Homo sapiens	109-113
23314282-2	2013	Their requirement is met, at least partially, with high-dose medroxyprogesterone acetate that brings good response rate in the treatment of endometrial cancer in the early stage and atypical complex endometrial hyperplasia (EC/ACEH).	Medroxyprogesterone Acetate	61-88	angiotensin converting enzyme 2	Homo sapiens	227-231
23314282-7	2013	METHODS: The patients with EC/ACEH who achieved complete response after high-dose medroxyprogesterone acetate were eligible for this retrospective study.	Medroxyprogesterone Acetate	82-109	angiotensin converting enzyme 2	Homo sapiens	30-34
23144053-9	2013	Urinary ACE2 concentrations appeared to correlate with HOMA-IR, fasting blood glucose, triglyceride, high-sensitivity C-reactive protein, serum creatinine, urinary ACR, and systolic blood pressure (all P&lt;0.05).	Creatinine	144-154	angiotensin converting enzyme 2	Homo sapiens	8-12
24158104-9	2013	Furthermore, cultured human MC showed increased ACE2 mRNA and protein after treatment with IL-1beta, a pro-inflammatory cytokine in IgAN.	Methylcholanthrene	28-30	angiotensin converting enzyme 2	Homo sapiens	48-52
23751363-5	2013	Actinomycin D (1 mg/ml), BQ123 (1 mumol/l), and the p38 mitogen-activated protein kinase (MAPK) siRNA and inhibitor PD169316 (25 mumol/l) completely abolished the effect of ET-1 on ACE2 expression in HBEpCs.	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole	116-124	angiotensin converting enzyme 2	Homo sapiens	181-185
22811473-3	2012	However, the possible involvement of the ACE2-ANG-(1-7)-Mas receptor system on enhanced jejunal glucose transport in T1DM has yet to be determined.	Glucose	96-103	angiotensin converting enzyme 2	Homo sapiens	41-45
23710811-0	2013	[The impact of telmisartan on angiotensin converting enzyme 2 mRNA expression in monocyte-derived macrophages of diabetic hypertensive patients].	Telmisartan	15-26	angiotensin converting enzyme 2	Homo sapiens	30-61
23710811-1	2013	OBJECTIVE: To investigate the effects of telmisartan on the expression of angiotensin converting enzyme 2 (ACE2) mRNA in monocyte-derived macrophages of hypertensive patients accompanied with diabetes.	Telmisartan	41-52	angiotensin converting enzyme 2	Homo sapiens	74-105
23710811-1	2013	OBJECTIVE: To investigate the effects of telmisartan on the expression of angiotensin converting enzyme 2 (ACE2) mRNA in monocyte-derived macrophages of hypertensive patients accompanied with diabetes.	Telmisartan	41-52	angiotensin converting enzyme 2	Homo sapiens	107-111
23710811-5	2013	CONCLUSION: The role of telmisartan in decreasing blood pressure and it"s advantage to the metabolism of glucose are partly related with the up-regulation of ACE2 mRNA.	Telmisartan	24-35	angiotensin converting enzyme 2	Homo sapiens	158-162
23710811-5	2013	CONCLUSION: The role of telmisartan in decreasing blood pressure and it"s advantage to the metabolism of glucose are partly related with the up-regulation of ACE2 mRNA.	Glucose	105-112	angiotensin converting enzyme 2	Homo sapiens	158-162
23720263-5	2012	In contrast, the nonclassical RAS composed primarily of the AngII/Ang III-AT2R pathway and the ACE2-Ang-(1-7)-AT7R axis generally opposes the actions of a stimulated Ang II-AT1R axis through an increase in nitric oxide and prostaglandins and mediates vasodilation, natriuresis, diuresis, and reduced oxidative stress.	Nitric Oxide	206-218	angiotensin converting enzyme 2	Homo sapiens	95-99
23720263-5	2012	In contrast, the nonclassical RAS composed primarily of the AngII/Ang III-AT2R pathway and the ACE2-Ang-(1-7)-AT7R axis generally opposes the actions of a stimulated Ang II-AT1R axis through an increase in nitric oxide and prostaglandins and mediates vasodilation, natriuresis, diuresis, and reduced oxidative stress.	Prostaglandins	223-237	angiotensin converting enzyme 2	Homo sapiens	95-99
22811473-9	2012	In conclusion, enhanced activity of the ACE2-ANG-(1-7)-Mas receptor axis in jejunal enterocytes is likely to moderate the T1DM-induced increase in jejunal glucose uptake resulting from downregulation of the ACE-ANG II-AT1 receptor axis.	Glucose	155-162	angiotensin converting enzyme 2	Homo sapiens	40-44
22811473-10	2012	Therefore, altered activity of both ACE and ACE2 systems during diabetes will determine the overall rate of glucose transport across the jejunal epithelium.	Glucose	108-115	angiotensin converting enzyme 2	Homo sapiens	44-48
21638102-1	2012	A novel angiotensin-converting enzyme (ACE) homolog, named ACE2, is a monocarboxypeptidase which metabolizes several peptides.	Peptides	117-125	angiotensin converting enzyme 2	Homo sapiens	59-63
22170620-8	2012	Moreover, blockade of either ACE2-the enzyme that converts ANG II to ANG-(1-7)-or the AT7 receptor exacerbates the ANG II-ROS response on renal nuclei.	Reactive Oxygen Species	122-125	angiotensin converting enzyme 2	Homo sapiens	29-33
22777933-12	2012	There are also species differences regarding rodent and human ACE2 inhibition by known inhibitors such that MLN-4760 inhibits both human and mouse ACE2, whereas DX600 only blocks human ACE2 activity.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	108-116	angiotensin converting enzyme 2	Homo sapiens	62-66
22777933-12	2012	There are also species differences regarding rodent and human ACE2 inhibition by known inhibitors such that MLN-4760 inhibits both human and mouse ACE2, whereas DX600 only blocks human ACE2 activity.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	108-116	angiotensin converting enzyme 2	Homo sapiens	147-151
22227126-4	2012	Hyperglycemia, insulin resistance, and/or specific cholesterol metabolites have been demonstrated to activate components required for the synthesis [angiotensinogen, renin, angiotensin-converting enzyme (ACE)], degradation (ACE2), or responsiveness (angiotensin II type 1 receptors, Mas receptors) to angiotensin peptides in cell types (e.g., pancreatic islet cells, adipocytes, macrophages) that mediate specific disorders of the metabolic syndrome.	Cholesterol	51-62	angiotensin converting enzyme 2	Homo sapiens	224-228
22647832-6	2012	BeWo cells did not express REN, and REN was not inducible by cAMP, but cAMP increased ACE2 and MAS1 (both P &lt; 0.05) and decreased AGT (P &lt; 0.05).	Cyclic AMP	71-75	angiotensin converting enzyme 2	Homo sapiens	86-90
22647832-11	2012	BeWo cells express the ACE2/Ang 1-7/Mas pathway, which is sensitive to cAMP and therefore are useful for studying the effects of ACE2/Ang 1-7/Mas on trophoblast function.	Cyclic AMP	71-75	angiotensin converting enzyme 2	Homo sapiens	23-27
22954122-5	2012	RESULTS: Four and 12 weeks after treatment, the systolic pressure and diastolic pressure of telmisartan group and benazepril group were significantly lower than that of the conventional treatment group (all P&lt;0.01), and the systolic pressure and diastolic pressure of telmisartan group were significantly lower than that of the benazepril group(both P&lt;0.01) .The expression of ACE2 mRNA in monocyte-derived macrophages were significantly lower in essential hypertensive patients than that in control group (P&lt;0.01).	Telmisartan	92-103	angiotensin converting enzyme 2	Homo sapiens	383-387
22954122-6	2012	After having been treated for 4 weeks and 12 weeks, the expression of ACE2 mRNA in monocyte-derived macrophages of hypertensive patients in telmisartan and benazepril groups were significantly higher than that in conventional treatment group (all P&lt;0.01), and the expression of ACE2 mRNA in telmisartan group was significantly higher than that in benazepril group (both P&lt;0.01).	benazepril	156-166	angiotensin converting enzyme 2	Homo sapiens	70-74
22954122-6	2012	After having been treated for 4 weeks and 12 weeks, the expression of ACE2 mRNA in monocyte-derived macrophages of hypertensive patients in telmisartan and benazepril groups were significantly higher than that in conventional treatment group (all P&lt;0.01), and the expression of ACE2 mRNA in telmisartan group was significantly higher than that in benazepril group (both P&lt;0.01).	benazepril	156-166	angiotensin converting enzyme 2	Homo sapiens	281-285
22954122-6	2012	After having been treated for 4 weeks and 12 weeks, the expression of ACE2 mRNA in monocyte-derived macrophages of hypertensive patients in telmisartan and benazepril groups were significantly higher than that in conventional treatment group (all P&lt;0.01), and the expression of ACE2 mRNA in telmisartan group was significantly higher than that in benazepril group (both P&lt;0.01).	benazepril	350-360	angiotensin converting enzyme 2	Homo sapiens	70-74
22291007-9	2012	The human-optimized RBD contains all of the hACE2-adapted residues (Phe-442, Phe-472, Asn-479, Asp-480, and Thr-487) and possesses exceptionally high affinity for hACE2 but relative low affinity for cACE2.	Phenylalanine	68-71	angiotensin converting enzyme 2	Homo sapiens	44-49
22291007-9	2012	The human-optimized RBD contains all of the hACE2-adapted residues (Phe-442, Phe-472, Asn-479, Asp-480, and Thr-487) and possesses exceptionally high affinity for hACE2 but relative low affinity for cACE2.	Phenylalanine	68-71	angiotensin converting enzyme 2	Homo sapiens	163-168
22291007-9	2012	The human-optimized RBD contains all of the hACE2-adapted residues (Phe-442, Phe-472, Asn-479, Asp-480, and Thr-487) and possesses exceptionally high affinity for hACE2 but relative low affinity for cACE2.	Phenylalanine	77-80	angiotensin converting enzyme 2	Homo sapiens	44-49
22291007-9	2012	The human-optimized RBD contains all of the hACE2-adapted residues (Phe-442, Phe-472, Asn-479, Asp-480, and Thr-487) and possesses exceptionally high affinity for hACE2 but relative low affinity for cACE2.	Phenylalanine	77-80	angiotensin converting enzyme 2	Homo sapiens	163-168
22291007-9	2012	The human-optimized RBD contains all of the hACE2-adapted residues (Phe-442, Phe-472, Asn-479, Asp-480, and Thr-487) and possesses exceptionally high affinity for hACE2 but relative low affinity for cACE2.	Asparagine	86-89	angiotensin converting enzyme 2	Homo sapiens	44-49
22291007-9	2012	The human-optimized RBD contains all of the hACE2-adapted residues (Phe-442, Phe-472, Asn-479, Asp-480, and Thr-487) and possesses exceptionally high affinity for hACE2 but relative low affinity for cACE2.	Aspartic Acid	95-98	angiotensin converting enzyme 2	Homo sapiens	44-49
22291007-9	2012	The human-optimized RBD contains all of the hACE2-adapted residues (Phe-442, Phe-472, Asn-479, Asp-480, and Thr-487) and possesses exceptionally high affinity for hACE2 but relative low affinity for cACE2.	Aspartic Acid	95-98	angiotensin converting enzyme 2	Homo sapiens	163-168
22291007-9	2012	The human-optimized RBD contains all of the hACE2-adapted residues (Phe-442, Phe-472, Asn-479, Asp-480, and Thr-487) and possesses exceptionally high affinity for hACE2 but relative low affinity for cACE2.	Threonine	108-111	angiotensin converting enzyme 2	Homo sapiens	44-49
22291007-9	2012	The human-optimized RBD contains all of the hACE2-adapted residues (Phe-442, Phe-472, Asn-479, Asp-480, and Thr-487) and possesses exceptionally high affinity for hACE2 but relative low affinity for cACE2.	Threonine	108-111	angiotensin converting enzyme 2	Homo sapiens	163-168
23257682-8	2012	ACE2 activity correlated positively with serum creatinine (r = 0.27), serum urea (r = 0.29), age (r = 0.24), aspartate transaminase (r = 0.39), alanine transaminase (r = 0.48), gamma-glutamyl transferase (gamma-GT) (r = 0.52), age (r = 0.24), and glycosylated hemoglobin (r = 0.19) (p &lt; 0.05).	Creatinine	47-57	angiotensin converting enzyme 2	Homo sapiens	0-4
32362932-1	2012	Angiotensin converting enzyme 2 (ACE2), is a monocarboxypeptidase which metabolizes several peptides including the degradation of Ang II, a peptide with vasoconstrictive/proliferative/effects, to generate Ang 1-7, which acting through its receptor Mas exerts vasodilatory/anti-proliferative actions.	Angiotensin II	130-136	angiotensin converting enzyme 2	Homo sapiens	0-31
32362932-1	2012	Angiotensin converting enzyme 2 (ACE2), is a monocarboxypeptidase which metabolizes several peptides including the degradation of Ang II, a peptide with vasoconstrictive/proliferative/effects, to generate Ang 1-7, which acting through its receptor Mas exerts vasodilatory/anti-proliferative actions.	Angiotensin II	130-136	angiotensin converting enzyme 2	Homo sapiens	33-37
32362932-6	2012	Human recombinant ACE2 has been safely administered to healthy human volunteers intravenously resulting in sustained lowering of plasma Ang II levels.	Angiotensin II	136-142	angiotensin converting enzyme 2	Homo sapiens	18-22
23257682-8	2012	ACE2 activity correlated positively with serum creatinine (r = 0.27), serum urea (r = 0.29), age (r = 0.24), aspartate transaminase (r = 0.39), alanine transaminase (r = 0.48), gamma-glutamyl transferase (gamma-GT) (r = 0.52), age (r = 0.24), and glycosylated hemoglobin (r = 0.19) (p &lt; 0.05).	Urea	76-80	angiotensin converting enzyme 2	Homo sapiens	0-4
23257682-9	2012	By multiple regression analysis, age, serum creatinine, and serum gamma-GT were independent predictors of serum ACE2 activity (r = 0.66, p &lt; 0.001).	Creatinine	44-54	angiotensin converting enzyme 2	Homo sapiens	112-116
23236535-6	2012	Based on our analyses, a human ACE2 inhibitor was selected for experimental testing on one of these parasite proteases, TbM32, and was shown to inhibit it.	tbm32	120-125	angiotensin converting enzyme 2	Homo sapiens	31-35
23095677-0	2012	Propofol increases angiotensin-converting enzyme 2 expression in human pulmonary artery endothelial cells.	Propofol	0-8	angiotensin converting enzyme 2	Homo sapiens	19-50
23095677-3	2012	In the present study, we explored the effect of propofol on ACE2 expression in human pulmonary artery endothelial cells (HPAECs).	Propofol	48-56	angiotensin converting enzyme 2	Homo sapiens	60-64
23095677-5	2012	RESULTS: Propofol increased the ACE2 mRNA level in a dose- and time-dependent manner within 24 h. Propofol treatment dose-dependently increased the ACE2 protein level and the cell membrane ACE2 activity.	Propofol	9-17	angiotensin converting enzyme 2	Homo sapiens	32-36
23095677-5	2012	RESULTS: Propofol increased the ACE2 mRNA level in a dose- and time-dependent manner within 24 h. Propofol treatment dose-dependently increased the ACE2 protein level and the cell membrane ACE2 activity.	Propofol	9-17	angiotensin converting enzyme 2	Homo sapiens	148-152
23095677-5	2012	RESULTS: Propofol increased the ACE2 mRNA level in a dose- and time-dependent manner within 24 h. Propofol treatment dose-dependently increased the ACE2 protein level and the cell membrane ACE2 activity.	Propofol	9-17	angiotensin converting enzyme 2	Homo sapiens	148-152
23095677-5	2012	RESULTS: Propofol increased the ACE2 mRNA level in a dose- and time-dependent manner within 24 h. Propofol treatment dose-dependently increased the ACE2 protein level and the cell membrane ACE2 activity.	Propofol	98-106	angiotensin converting enzyme 2	Homo sapiens	32-36
23095677-5	2012	RESULTS: Propofol increased the ACE2 mRNA level in a dose- and time-dependent manner within 24 h. Propofol treatment dose-dependently increased the ACE2 protein level and the cell membrane ACE2 activity.	Propofol	98-106	angiotensin converting enzyme 2	Homo sapiens	148-152
23095677-5	2012	RESULTS: Propofol increased the ACE2 mRNA level in a dose- and time-dependent manner within 24 h. Propofol treatment dose-dependently increased the ACE2 protein level and the cell membrane ACE2 activity.	Propofol	98-106	angiotensin converting enzyme 2	Homo sapiens	148-152
23095677-6	2012	Transcription inhibitor actinomycin D and PI3K inhibitor LY294002 abrogated the augmenting effect of propofol on the mRNA level of ACE2 in HPAECs.	Dactinomycin	24-37	angiotensin converting enzyme 2	Homo sapiens	131-135
23095677-6	2012	Transcription inhibitor actinomycin D and PI3K inhibitor LY294002 abrogated the augmenting effect of propofol on the mRNA level of ACE2 in HPAECs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	57-65	angiotensin converting enzyme 2	Homo sapiens	131-135
23095677-6	2012	Transcription inhibitor actinomycin D and PI3K inhibitor LY294002 abrogated the augmenting effect of propofol on the mRNA level of ACE2 in HPAECs.	Propofol	101-109	angiotensin converting enzyme 2	Homo sapiens	131-135
23095677-7	2012	CONCLUSION: Propofol enhances the ACE2 expression in HPAECs by increasing the transcription of ACE2 via a PI3K-dependent mechanism, which leads to increased ACE2 activity on the cell membrane.	Propofol	12-20	angiotensin converting enzyme 2	Homo sapiens	34-38
23095677-7	2012	CONCLUSION: Propofol enhances the ACE2 expression in HPAECs by increasing the transcription of ACE2 via a PI3K-dependent mechanism, which leads to increased ACE2 activity on the cell membrane.	Propofol	12-20	angiotensin converting enzyme 2	Homo sapiens	95-99
23095677-7	2012	CONCLUSION: Propofol enhances the ACE2 expression in HPAECs by increasing the transcription of ACE2 via a PI3K-dependent mechanism, which leads to increased ACE2 activity on the cell membrane.	Propofol	12-20	angiotensin converting enzyme 2	Homo sapiens	95-99
21880865-3	2011	Whereas recombinant human ACE2 is readily detected in mouse tissues using 1 muM DX600 at pH 7.5, the endogenous ACE2 activity in mouse tissues is barely detectable.	dx600	80-85	angiotensin converting enzyme 2	Homo sapiens	26-30
22693641-9	2012	Our findings reveal that ACE2 deficiency worsens Ang II-mediated aortic inflammation and peroxynitrite production associated with the augmentation of profilin-1 expression and the activation of the Akt-ERK-eNOS signaling, suggesting potential therapeutic approaches by enhancing ACE2 action for patients with vascular diseases.	Peroxynitrous Acid	89-102	angiotensin converting enzyme 2	Homo sapiens	25-29
21880865-5	2011	ACE2 from all three species could be inhibited by DX600, but the half maximal inhibitory concentration (IC(50)) for human ACE2 was much lower (78-fold) than for rodent ACE2.	dx600	50-55	angiotensin converting enzyme 2	Homo sapiens	0-4
21880865-5	2011	ACE2 from all three species could be inhibited by DX600, but the half maximal inhibitory concentration (IC(50)) for human ACE2 was much lower (78-fold) than for rodent ACE2.	dx600	50-55	angiotensin converting enzyme 2	Homo sapiens	122-126
21880865-5	2011	ACE2 from all three species could be inhibited by DX600, but the half maximal inhibitory concentration (IC(50)) for human ACE2 was much lower (78-fold) than for rodent ACE2.	dx600	50-55	angiotensin converting enzyme 2	Homo sapiens	122-126
21563828-3	2011	In this study, we demonstrate that purified recombinant human ADAM17 is able to cleave a 20-amino acid peptide mimetic corresponding to the extracellular juxtamembrane region of human ACE2 between Arg(708) and Ser(709).	Arginine	197-200	angiotensin converting enzyme 2	Homo sapiens	184-188
21481527-6	2011	In addition, restoration of ACE2 expression mediated by adenovirus vector significantly inhibited the established tumor growth, strongly enhanced the anti-tumor activity of gemcitabine in a pancreatic cancer xenograft model in vivo, and significantly prolonged the survival time of animals bearing tumor xenografts.	gemcitabine	173-184	angiotensin converting enzyme 2	Homo sapiens	28-32
21685445-4	2011	The results of the present study demonstrated that intracerebroventricular infusion of either Ang-(1-7) or an ACE2 activator, diminazine aceturate (DIZE), prior to and following ET-1-induced MCAO significantly attenuated the cerebral infarct size and neurological deficits measured 72 h after the insult.	diminazene aceturate	126-146	angiotensin converting enzyme 2	Homo sapiens	110-114
21685445-4	2011	The results of the present study demonstrated that intracerebroventricular infusion of either Ang-(1-7) or an ACE2 activator, diminazine aceturate (DIZE), prior to and following ET-1-induced MCAO significantly attenuated the cerebral infarct size and neurological deficits measured 72 h after the insult.	diminazene aceturate	148-152	angiotensin converting enzyme 2	Homo sapiens	110-114
21563828-3	2011	In this study, we demonstrate that purified recombinant human ADAM17 is able to cleave a 20-amino acid peptide mimetic corresponding to the extracellular juxtamembrane region of human ACE2 between Arg(708) and Ser(709).	Serine	210-213	angiotensin converting enzyme 2	Homo sapiens	184-188
21563828-7	2011	In summary, we have demonstrated that ADAM17 is able to cleave ACE2 peptide sequence analogues between Arg(708) and Ser(709).	Arginine	103-106	angiotensin converting enzyme 2	Homo sapiens	63-67
21563828-7	2011	In summary, we have demonstrated that ADAM17 is able to cleave ACE2 peptide sequence analogues between Arg(708) and Ser(709).	Serine	116-119	angiotensin converting enzyme 2	Homo sapiens	63-67
21563828-8	2011	These findings also indicate that Arg(708) and Arg(710) play a role in site recognition in the regulation of ACE2 ectodomain shedding mediated by ADAM17.	Arginine	34-37	angiotensin converting enzyme 2	Homo sapiens	109-113
21563828-8	2011	These findings also indicate that Arg(708) and Arg(710) play a role in site recognition in the regulation of ACE2 ectodomain shedding mediated by ADAM17.	Arginine	47-50	angiotensin converting enzyme 2	Homo sapiens	109-113
21449848-7	2011	CONCLUSION: Gender-specific gene-gene interactions of the AGT, AGTR1 and ACE2 genes were associated with individual variation of response to benazepril.	benazepril	141-151	angiotensin converting enzyme 2	Homo sapiens	73-77
20549604-0	2011	beta-Amino acid substitution to investigate the recognition of angiotensin II (AngII) by angiotensin converting enzyme 2 (ACE2).	beta-amino acid	0-15	angiotensin converting enzyme 2	Homo sapiens	122-126
20549604-4	2011	The beta-amino acid-substituted AngII analogs showed differences in secondary structure, ACE2 binding and proteolytic stability.	beta-amino acid	4-19	angiotensin converting enzyme 2	Homo sapiens	89-93
20549604-8	2011	beta-amino acid substitution in the C-terminal region significantly diminished both secondary structure and proteolytic processing by ACE2.	beta-amino acid	0-15	angiotensin converting enzyme 2	Homo sapiens	134-138
21298017-8	2011	Notably, cyclosporine represses HNF4alpha gene and protein expression and its DNA-binding activity at consensus sequences to AGT, AGTR1, ACE, and ACE2.	Cyclosporine	9-21	angiotensin converting enzyme 2	Homo sapiens	146-150
20816713-3	2010	Particular emphasis was given to the influence of the balance between the ACE-angiotensin II and of the ACE2-angiotensin (1-7)-Mas receptor axis on heart cell volume regulation and on the swelling-dependent chloride current.	Chlorides	207-215	angiotensin converting enzyme 2	Homo sapiens	104-108
21265092-5	2010	RESULTS: (1) ACE2 protein expression decreased after hypoxia treatment for 3 h, 6 h, 12 h, and 24 hour compared with regular oxygen condition (chi2 = 825.078, 768.141, 623.931, 350.260, P &lt; 0.00625), the maximum reduction came at 3 h after hypoxia exposure, then raised gradually after 6 h, 12 h, and 24 h exposure; (2) ACE2 mRNA expression show a similar tendency to ACE2 protein.	Oxygen	125-131	angiotensin converting enzyme 2	Homo sapiens	13-17
20224560-0	2010	Association of genetic variants in the apelin-APJ system and ACE2 with blood pressure responses to potassium supplementation: the GenSalt study.	Potassium	99-108	angiotensin converting enzyme 2	Homo sapiens	61-65
20559404-0	2010	[Correlation of angiotensin-converting enzyme 2 gene polymorphism with antihypertensive effects of benazepril].	benazepril	99-109	angiotensin converting enzyme 2	Homo sapiens	16-47
20559404-1	2010	OBJECTIVE: To explore the correlation of rs2106809 from angiotensin-converting enzyme 2 gene with antihypertensive effects of benazepril, as well as its interactions with polymorphisms of angiotensinogen(AGT) and angiotensin II type 1 receptor(AGTR1) gene.	benazepril	126-136	angiotensin converting enzyme 2	Homo sapiens	56-87
20660625-6	2010	RESULTS: In 8-week-old db/db mice, Ad-hACE2-eGFP significantly improved fasting glycemia, enhanced intraperitoneal glucose tolerance, increased islet insulin content and beta-cell proliferation, and reduced beta-cell apoptosis compared with Ad-eGFP.	Glucose	115-122	angiotensin converting enzyme 2	Homo sapiens	38-43
20660625-10	2010	In 16-week-old diabetic mice, Ad-hACE2-eGFP treatment improved fasting blood glucose but had no effect on any of the other parameters.	Glucose	77-84	angiotensin converting enzyme 2	Homo sapiens	33-38
20679547-4	2010	Daily treatment of Ang II-infused wild-type mice with recombinant human ACE2 (rhACE2; 2 mg x kg(-1) x d(-1) IP) blunted the hypertrophic response and expression of hypertrophy markers and reduced Ang II-induced superoxide production.	Superoxides	211-221	angiotensin converting enzyme 2	Homo sapiens	72-76
20224560-2	2010	We examined the association of genetic variants in the apelin-APJ system and angiotensin-converting enzyme 2 (ACE2) with BP responses to potassium supplementation.	Potassium	137-146	angiotensin converting enzyme 2	Homo sapiens	77-108
20224560-2	2010	We examined the association of genetic variants in the apelin-APJ system and angiotensin-converting enzyme 2 (ACE2) with BP responses to potassium supplementation.	Potassium	137-146	angiotensin converting enzyme 2	Homo sapiens	110-114
20224560-8	2010	In men, SNP rs4646174 of the ACE2 gene was significantly associated with systolic BP (SBP), DBP, and mean arterial pressure (MAP) responses to potassium supplementation (P = 0.0001, P = 0.001, and P = 3.0 x 10(-6), respectively).	Potassium	143-152	angiotensin converting enzyme 2	Homo sapiens	29-33
20224560-10	2010	CONCLUSION: Our study indicates that genetic variation of APLN and ACE2 may influence BP response to potassium intake.	Potassium	101-110	angiotensin converting enzyme 2	Homo sapiens	67-71
19717501-9	2009	Administration of nifedipine (1 microM) protected cells from this ACE2 protein reduction at the HAEC membrane.	Nifedipine	18-28	angiotensin converting enzyme 2	Homo sapiens	66-70
20424953-5	2010	It has been shown that brain ACE2 interacts with the other components of the RAS (ACE, angiotensin II, and angiotensin II type 1 receptor), protects baroreflex and autonomic function, stimulates nitric oxide release, reduces oxidative stress, and prevents the development of or attenuates hypertension.	Nitric Oxide	195-207	angiotensin converting enzyme 2	Homo sapiens	29-33
20226173-6	2010	Results showed that TOP His(600) residue makes important interactions with the substrate, supporting the prediction that His(600) moves toward the substrate due to a hinge movement similar to the Dcp and ACE-2.	Histidine	24-27	angiotensin converting enzyme 2	Homo sapiens	204-209
20226173-6	2010	Results showed that TOP His(600) residue makes important interactions with the substrate, supporting the prediction that His(600) moves toward the substrate due to a hinge movement similar to the Dcp and ACE-2.	Histidine	121-124	angiotensin converting enzyme 2	Homo sapiens	204-209
20125035-8	2010	Six SNPs of the ACE2 gene were significantly associated with SBP, DBP, or MAP responses to low-sodium intervention.	Sodium	95-101	angiotensin converting enzyme 2	Homo sapiens	16-20
20125035-11	2010	CONCLUSION: This large family-based study indicates that genetic variants in the APLNR and ACE2 genes are significantly associated with BP responses to dietary sodium intervention.	Sodium	160-166	angiotensin converting enzyme 2	Homo sapiens	91-95
19927151-2	2010	Olmesartan is a potential ARB inducing activation of angiotensin-converting enzyme 2 (ACE2) that hydrolyzes Ang II to Ang 1-7, and has shown a beneficial effect on ventricular remodeling.	olmesartan	0-10	angiotensin converting enzyme 2	Homo sapiens	53-84
19927151-2	2010	Olmesartan is a potential ARB inducing activation of angiotensin-converting enzyme 2 (ACE2) that hydrolyzes Ang II to Ang 1-7, and has shown a beneficial effect on ventricular remodeling.	olmesartan	0-10	angiotensin converting enzyme 2	Homo sapiens	86-90
19411314-5	2009	Constitutive generation of soluble ACE2 was inhibited by DPC 333, implicating a disintegrin and metalloprotease 17 (ADAM17).	dpc	57-60	angiotensin converting enzyme 2	Homo sapiens	35-39
19411314-6	2009	Phorbol ester, ionomycin, endotoxin, and IL-1beta and TNFalpha acutely induced ACE2 release, further supporting that ADAM17 and ADAM10 regulate ACE2 cleavage.	Phorbol Esters	0-13	angiotensin converting enzyme 2	Homo sapiens	79-83
19411314-6	2009	Phorbol ester, ionomycin, endotoxin, and IL-1beta and TNFalpha acutely induced ACE2 release, further supporting that ADAM17 and ADAM10 regulate ACE2 cleavage.	Phorbol Esters	0-13	angiotensin converting enzyme 2	Homo sapiens	144-148
19411314-6	2009	Phorbol ester, ionomycin, endotoxin, and IL-1beta and TNFalpha acutely induced ACE2 release, further supporting that ADAM17 and ADAM10 regulate ACE2 cleavage.	Ionomycin	15-24	angiotensin converting enzyme 2	Homo sapiens	79-83
19411314-6	2009	Phorbol ester, ionomycin, endotoxin, and IL-1beta and TNFalpha acutely induced ACE2 release, further supporting that ADAM17 and ADAM10 regulate ACE2 cleavage.	Ionomycin	15-24	angiotensin converting enzyme 2	Homo sapiens	144-148
19232015-5	2009	Activities of ACE1 and ACE2 and their inhibition by bioactive tripeptides (Ile-Pro-Pro, Val-Pro-Pro, Leu-Pro-Pro) as well as by a standard ACE-inhibitor captopril were assayed in the vitreous body, the retina and the ciliary body using fluorometric detection methods.	tripeptides	62-73	angiotensin converting enzyme 2	Homo sapiens	23-27
19141296-10	2009	Captopril, however, attenuated the expression of ACE but increased expression of ACE2 induced by BSA.	Captopril	0-9	angiotensin converting enzyme 2	Homo sapiens	81-85
19164471-3	2009	We have recently shown that like ACE, ACE2 undergoes ectodomain shedding and that this shedding event is up-regulated by phorbol esters.	Phorbol Esters	121-135	angiotensin converting enzyme 2	Homo sapiens	38-42
19164471-4	2009	In the present study, we used gel shift assays to demonstrate that calmodulin, an intracellular calcium-binding protein implicated in the regulation of other ectodomain shedding events, binds a 16-amino acid synthetic peptide corresponding to residues 762-777 within the cytoplasmic domain of human ACE2, forming a calcium-dependent calmodulin-peptide complex.	Calcium	96-103	angiotensin converting enzyme 2	Homo sapiens	299-303
19164471-7	2009	Both trifluoperazine (25 micromol/liter) and calmidazolium, (25 micromol/liter) significantly increased the release of ACE2 into the medium (44.1 +/- 10.8%, P < 0.05, Student"s t test; unpaired, two-tailed, and 51.1 +/- 7.4% P < 0.05, one-way ANOVA, respectively;), as analyzed by an ACE2-specific quenched fluorescence substrate assay.	Trifluoperazine	5-20	angiotensin converting enzyme 2	Homo sapiens	119-123
19164471-7	2009	Both trifluoperazine (25 micromol/liter) and calmidazolium, (25 micromol/liter) significantly increased the release of ACE2 into the medium (44.1 +/- 10.8%, P < 0.05, Student"s t test; unpaired, two-tailed, and 51.1 +/- 7.4% P < 0.05, one-way ANOVA, respectively;), as analyzed by an ACE2-specific quenched fluorescence substrate assay.	Trifluoperazine	5-20	angiotensin converting enzyme 2	Homo sapiens	284-288
19164471-7	2009	Both trifluoperazine (25 micromol/liter) and calmidazolium, (25 micromol/liter) significantly increased the release of ACE2 into the medium (44.1 +/- 10.8%, P < 0.05, Student"s t test; unpaired, two-tailed, and 51.1 +/- 7.4% P < 0.05, one-way ANOVA, respectively;), as analyzed by an ACE2-specific quenched fluorescence substrate assay.	calmidazolium	45-58	angiotensin converting enzyme 2	Homo sapiens	119-123
19164471-7	2009	Both trifluoperazine (25 micromol/liter) and calmidazolium, (25 micromol/liter) significantly increased the release of ACE2 into the medium (44.1 +/- 10.8%, P < 0.05, Student"s t test; unpaired, two-tailed, and 51.1 +/- 7.4% P < 0.05, one-way ANOVA, respectively;), as analyzed by an ACE2-specific quenched fluorescence substrate assay.	calmidazolium	45-58	angiotensin converting enzyme 2	Homo sapiens	284-288
19232015-5	2009	Activities of ACE1 and ACE2 and their inhibition by bioactive tripeptides (Ile-Pro-Pro, Val-Pro-Pro, Leu-Pro-Pro) as well as by a standard ACE-inhibitor captopril were assayed in the vitreous body, the retina and the ciliary body using fluorometric detection methods.	isoleucyl-prolyl-proline	75-86	angiotensin converting enzyme 2	Homo sapiens	23-27
19232015-5	2009	Activities of ACE1 and ACE2 and their inhibition by bioactive tripeptides (Ile-Pro-Pro, Val-Pro-Pro, Leu-Pro-Pro) as well as by a standard ACE-inhibitor captopril were assayed in the vitreous body, the retina and the ciliary body using fluorometric detection methods.	valyl-prolyl-proline	88-99	angiotensin converting enzyme 2	Homo sapiens	23-27
19232015-5	2009	Activities of ACE1 and ACE2 and their inhibition by bioactive tripeptides (Ile-Pro-Pro, Val-Pro-Pro, Leu-Pro-Pro) as well as by a standard ACE-inhibitor captopril were assayed in the vitreous body, the retina and the ciliary body using fluorometric detection methods.	leucyl-prolyl-proline	101-112	angiotensin converting enzyme 2	Homo sapiens	23-27
19232015-9	2009	The tripeptides inhibited ACE1 at one-thousandth of the concentration needed to inhibit ACE2.	tripeptides	4-15	angiotensin converting enzyme 2	Homo sapiens	88-92
19021774-0	2008	Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis.	Chlorides	23-31	angiotensin converting enzyme 2	Homo sapiens	116-120
19021774-2	2008	Both ACE and ACE2 have catalytic activity that is chloride sensitive and is caused by the presence of the CL1 and CL2 chloride-binding sites in ACE and the CL1 site in ACE2.	Chlorides	50-58	angiotensin converting enzyme 2	Homo sapiens	13-17
19021774-2	2008	Both ACE and ACE2 have catalytic activity that is chloride sensitive and is caused by the presence of the CL1 and CL2 chloride-binding sites in ACE and the CL1 site in ACE2.	Chlorides	50-58	angiotensin converting enzyme 2	Homo sapiens	168-172
19021774-5	2008	The CL1 site residues Arg186, Trp279 and Arg489 of testicular ACE and the equivalent ACE2 residues Arg169, Trp271 and Lys481 were found to be critical to chloride sensitivity.	Chlorides	154-162	angiotensin converting enzyme 2	Homo sapiens	85-89
19021774-9	2008	Inhibition of ACE2 was also found to be chloride sensitive, as for testicular ACE, with residues Arg169 and Arg514 of ACE2 identified as influencing the potency of the ACE2-specific inhibitor MLN-4760.	Chlorides	40-48	angiotensin converting enzyme 2	Homo sapiens	14-18
19021774-10	2008	Consequently, important insights into the chloride sensitivity, substrate selectivity and inhibition of testicular ACE and ACE2 were elucidated.	Chlorides	42-50	angiotensin converting enzyme 2	Homo sapiens	123-127
18814896-0	2008	Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2.	Cholesterol	14-25	angiotensin converting enzyme 2	Homo sapiens	136-167
18814896-5	2008	We found that ACE2 of both Vero E6 and Caco-2 cells co-purifies with marker proteins of detergent-resistant membranes supporting the notion that cholesterol-rich microdomains provide a platform facilitating the efficient interaction of the S protein with the cellular receptor ACE2.	Cholesterol	145-156	angiotensin converting enzyme 2	Homo sapiens	277-281
18814896-8	2008	Depletion of cholesterol from the ACE2-expressing cells reduced the binding of S-expressing cells by 50% whereas the binding of soluble S protein was not affected.	Cholesterol	13-24	angiotensin converting enzyme 2	Homo sapiens	34-38
18660448-8	2008	ACE2 attenuated ANG II-induced reactive oxygen species production in part through decreasing the expression of p22phox.	Reactive Oxygen Species	31-54	angiotensin converting enzyme 2	Homo sapiens	0-4
18223028-5	2008	In this study, we demonstrate the presence of ACE2 as an ectoenzyme and reveal that ACE2 undergoes phorbol-12-myristate-13-acetate-inducible ectodomain shedding from the membrane.	Tetradecanoylphorbol Acetate	99-130	angiotensin converting enzyme 2	Homo sapiens	46-50
18441099-9	2008	Moreover, purified recombinant human ACE-2, delivered to mice systemically by osmotic minipump, attenuated bleomycin-induced lung collagen accumulation.	Bleomycin	107-116	angiotensin converting enzyme 2	Homo sapiens	37-42
18389211-8	2008	In the ACEI group, there was a significant inverse correlation between the rate of GFR decline and urinary ACE2 expression at baseline (r= -0.423, p=0.031) as well as at 12 weeks (r= -0.395, p=0.046).	acei	7-11	angiotensin converting enzyme 2	Homo sapiens	107-111
18279660-4	2008	Depletion of plasma membrane cholesterol with MbetaCD relocalized raft-resident marker caveolin-1 as well as SARS-CoV receptor ACE2 to a nonraft environment, but did not significantly change the surface expression of ACE2.	Cholesterol	29-40	angiotensin converting enzyme 2	Homo sapiens	127-131
18403595-6	2008	In vitro, Ang II was able to up-regulate ACE and down-regulate ACE2 in human kidney tubular cells, which were blocked by an angiotensin II (AT)1 receptor antagonist (losartan), but not by an AT2 receptor blocker (PD123319).	Losartan	166-174	angiotensin converting enzyme 2	Homo sapiens	63-67
18223028-5	2008	In this study, we demonstrate the presence of ACE2 as an ectoenzyme and reveal that ACE2 undergoes phorbol-12-myristate-13-acetate-inducible ectodomain shedding from the membrane.	Tetradecanoylphorbol Acetate	99-130	angiotensin converting enzyme 2	Homo sapiens	84-88
18223028-8	2008	In paraffin sections of atrial appendage tissue, we observed a distinct staining pattern for ACE2 which appeared different from that of ACE.	Paraffin	3-11	angiotensin converting enzyme 2	Homo sapiens	93-97
18371537-10	2008	ACE/ACE2 ratio correlated positively with values for mean blood pressure, fasting blood glucose, serum creatinine, proteinuria, and hemoglobin A(1c) and inversely with estimated glomerular filtration rate (P < 0.001).	Glucose	88-95	angiotensin converting enzyme 2	Homo sapiens	4-8
18324760-4	2008	A model of interaction between one inhibitor of this series and ACE2 suggests that the critical role played by a proline in inhibitors, but also for substrates hydrolysis, may rely on the presence of Tyr (510) in the ACE2 active site.	Proline	113-120	angiotensin converting enzyme 2	Homo sapiens	64-68
18324760-4	2008	A model of interaction between one inhibitor of this series and ACE2 suggests that the critical role played by a proline in inhibitors, but also for substrates hydrolysis, may rely on the presence of Tyr (510) in the ACE2 active site.	Proline	113-120	angiotensin converting enzyme 2	Homo sapiens	217-221
18324760-4	2008	A model of interaction between one inhibitor of this series and ACE2 suggests that the critical role played by a proline in inhibitors, but also for substrates hydrolysis, may rely on the presence of Tyr (510) in the ACE2 active site.	Tyrosine	200-203	angiotensin converting enzyme 2	Homo sapiens	64-68
18324760-4	2008	A model of interaction between one inhibitor of this series and ACE2 suggests that the critical role played by a proline in inhibitors, but also for substrates hydrolysis, may rely on the presence of Tyr (510) in the ACE2 active site.	Tyrosine	200-203	angiotensin converting enzyme 2	Homo sapiens	217-221
18324760-2	2008	Here we report the discovery of potent and selective inhibitors of ACE2, which have been identified by evaluating a series of phosphinic di- and tripeptides of the general formula: Z-Xaa(PO 2-CH 2)YaaOH and Ac-Zaa-Xaa(PO 2-CH 2)YaaOH.	di- and tripeptides	137-156	angiotensin converting enzyme 2	Homo sapiens	67-71
18324760-3	2008	The most potent inhibitor in this series is a tripeptide that displays a K i value of 0.4 nM toward ACE2 and is 3 orders of magnitude less potent toward carboxypeptidase A. Phosphinic tripeptides exhibit high potency exclusively when the Xaa position is occupied by a pseudoproline.	tripeptide K-26	46-56	angiotensin converting enzyme 2	Homo sapiens	100-104
18324760-3	2008	The most potent inhibitor in this series is a tripeptide that displays a K i value of 0.4 nM toward ACE2 and is 3 orders of magnitude less potent toward carboxypeptidase A. Phosphinic tripeptides exhibit high potency exclusively when the Xaa position is occupied by a pseudoproline.	tripeptides	184-195	angiotensin converting enzyme 2	Homo sapiens	100-104
18371537-10	2008	ACE/ACE2 ratio correlated positively with values for mean blood pressure, fasting blood glucose, serum creatinine, proteinuria, and hemoglobin A(1c) and inversely with estimated glomerular filtration rate (P < 0.001).	Creatinine	103-113	angiotensin converting enzyme 2	Homo sapiens	4-8
18243695-0	2008	Thiol-based angiotensin-converting enzyme 2 inhibitors: P1" modifications for the exploration of the S1" subsite.	Sulfhydryl Compounds	0-5	angiotensin converting enzyme 2	Homo sapiens	12-43
18070603-2	2008	We have previously shown that ACE2 can be shed from the cell surface in response to phorbol esters by a process involving TNF-alpha converting enzyme (TACE; ADAM17).	Phorbol Esters	84-98	angiotensin converting enzyme 2	Homo sapiens	30-34
18199653-8	2008	Rapid hACE2-dependent S-mediated cell-cell fusion was reduced to 60 to 70% of the wild-type level for all single alanine substitutions and the Y1188A/Y1191A protein.	Alanine	113-120	angiotensin converting enzyme 2	Homo sapiens	6-11
18078750-0	2008	Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.	Sulfhydryl Compounds	0-5	angiotensin converting enzyme 2	Homo sapiens	12-43
18078750-1	2008	Screening of a metalloprotease library led to the identification of a thiol-based dual ACE/NEP inhibitor as a potent ACE2 inhibitor.	Sulfhydryl Compounds	70-75	angiotensin converting enzyme 2	Homo sapiens	117-121
17703127-3	2007	ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II.	Phenylalanine	95-98	angiotensin converting enzyme 2	Homo sapiens	0-4
17906677-5	2008	KEY RESULTS: Gene transfer of ACE2 suppressed the expression of p22phox and MIF induced by angiotensin (Ang) II and Ang IV, accompanied by a decreased level of malondialdehyde in cells.	Malondialdehyde	160-175	angiotensin converting enzyme 2	Homo sapiens	30-34
17906677-6	2008	In addition, Ang II diminished insulin-stimulated phosphorylation of Akt (at Ser(473)) and eNOS (at Ser(1177)) and NO generation, effects which were reversed by ACE2 gene transfer and anti-MIF treatment in endothelial cells.	Serine	100-103	angiotensin converting enzyme 2	Homo sapiens	161-165
17473847-0	2007	Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women.	Captopril	102-111	angiotensin converting enzyme 2	Homo sapiens	17-21
17473847-5	2007	The adjusted diastolic blood pressure response to Captopril was 3.3 mm Hg lower in ACE2 T allele carriers than in CC genotype carriers (P=0.019) in women.	Captopril	50-59	angiotensin converting enzyme 2	Homo sapiens	83-87
16730806-8	2007	Emodin, an anthraquinone compound derived from genus Rheum and Polygonum, significantly blocked the S protein and ACE2 interaction in a dose-dependent manner.	Anthraquinones	11-24	angiotensin converting enzyme 2	Homo sapiens	114-118
17522231-5	2007	Furthermore, the SARS-CoV entered COS7 cells transfected with the mutant of ACE2 with the cytoplasmic tail deleted, SARS-CoV receptor, as well as the wild-type ACE2, and their entries were significantly inhibited by treatment with chlorpromazine.	Chlorpromazine	231-245	angiotensin converting enzyme 2	Homo sapiens	76-80
17522231-5	2007	Furthermore, the SARS-CoV entered COS7 cells transfected with the mutant of ACE2 with the cytoplasmic tail deleted, SARS-CoV receptor, as well as the wild-type ACE2, and their entries were significantly inhibited by treatment with chlorpromazine.	Chlorpromazine	231-245	angiotensin converting enzyme 2	Homo sapiens	160-164
17095582-5	2007	The activities of ACE2 were determined by measuring leucine or phenylalanine released following hydrolysis of Ang I and Ang II, respectively.	Leucine	52-59	angiotensin converting enzyme 2	Homo sapiens	18-22
17095582-5	2007	The activities of ACE2 were determined by measuring leucine or phenylalanine released following hydrolysis of Ang I and Ang II, respectively.	Phenylalanine	63-76	angiotensin converting enzyme 2	Homo sapiens	18-22
16822235-9	2006	In conclusion, the results of the present study indicate that common genetic variants in the ACE2 gene might impact on MI in females, and may possibly interact with alcohol consumption to affect the risk of CHD and MI in Chinese males.	Alcohols	165-172	angiotensin converting enzyme 2	Homo sapiens	93-97
16122388-8	2005	Alanine scanning mutagenesis of the fragment S319-518 resulted in the identification of ten residues (K390, R426, D429, T431, I455, N473, F483, Q492, Y494, R495) that significantly reduced binding to ACE2, and one residue (D393) that appears to increase binding.	Alanine	0-7	angiotensin converting enzyme 2	Homo sapiens	200-204
16912312-4	2006	In contrast, several amino acid exchanges in human ACE2 which diminish SARS-S-driven entry do not interfere with NL63-S-mediated infection, suggesting that SARS-S and NL63-S might engage human ACE2 differentially.	sars-s	71-77	angiotensin converting enzyme 2	Homo sapiens	51-55
16912312-4	2006	In contrast, several amino acid exchanges in human ACE2 which diminish SARS-S-driven entry do not interfere with NL63-S-mediated infection, suggesting that SARS-S and NL63-S might engage human ACE2 differentially.	sars-s	71-77	angiotensin converting enzyme 2	Homo sapiens	193-197
16510163-3	2006	Alanine scanning mutagenesis analysis was performed to identify determinants on ACE2 critical for SARS-CoV infection.	Alanine	0-7	angiotensin converting enzyme 2	Homo sapiens	80-84
16510163-7	2006	One peptide comprised of two discontinuous segments of ACE2 (a.a. 22-44 and 351-357) artificially linked together by glycine, exhibited a potent antiviral activity with IC50 of about 0.1 microM.	Glycine	117-124	angiotensin converting enzyme 2	Homo sapiens	55-59
16647014-1	2006	OBJECTIVE: To investigate the effect of telmisartan on the protein and gene expression of angiotensin-converting enzyme-2 (ACE2) in human umbilical vein endothelial cells (HUVECs).	Telmisartan	40-51	angiotensin converting enzyme 2	Homo sapiens	90-121
16647014-1	2006	OBJECTIVE: To investigate the effect of telmisartan on the protein and gene expression of angiotensin-converting enzyme-2 (ACE2) in human umbilical vein endothelial cells (HUVECs).	Telmisartan	40-51	angiotensin converting enzyme 2	Homo sapiens	123-127
16647014-6	2006	RESULTS: Telmisartan induced a concentration and time dependent increase in both protein and gene expression of ACE2 (P<0.05 or P<0.01).	Telmisartan	9-20	angiotensin converting enzyme 2	Homo sapiens	112-116
16647014-7	2006	Compared with control group, treatment of HUVECs with telmisartan at the concentration of 10(-7), 10(-6) and 10(-5) mol/L stimulated 1.5-, 2.7- and 4.6-fold increase in the ACE2 protein expression, as well as 1.2-, 2.3- and 4.5-fold increase in its gene expression, respectively.	Telmisartan	54-65	angiotensin converting enzyme 2	Homo sapiens	173-177
16647014-8	2006	After treatment of HUVECs with telmisartan for 6, 12, and 24 hours at the concentration of 10(-6) mol/L, the ACE2 protein expression increased 1.6-, 2.7- and 4.2-fold, and its gene expression increased 1.3-, 2.3- and 4.0-fold, respectively.	Telmisartan	31-42	angiotensin converting enzyme 2	Homo sapiens	109-113
32288695-6	2006	Levels of ACE2 were surprisingly higher than ACE, which may reflect preferential targeting of the enzyme to the luminal surface of the renal epithelium.	Phenobarbital	112-119	angiotensin converting enzyme 2	Homo sapiens	10-14
16597622-7	2006	The antibody epitope is dominated by a 10-residue-long protruding beta6-beta7 loop with two putative ACE2-binding hotspot residues (Ile-489 and Tyr-491).	Isoleucine	132-135	angiotensin converting enzyme 2	Homo sapiens	101-105
16597622-7	2006	The antibody epitope is dominated by a 10-residue-long protruding beta6-beta7 loop with two putative ACE2-binding hotspot residues (Ile-489 and Tyr-491).	Tyrosine	144-147	angiotensin converting enzyme 2	Homo sapiens	101-105
15983030-5	2005	We demonstrated that ACE2, heterologously expressed in HEK293 cells and endogenously expressed in Huh7 cells, undergoes metalloproteinase-mediated, phorbol ester-inducible ectodomain shedding.	Phorbol Esters	148-161	angiotensin converting enzyme 2	Homo sapiens	21-25
15549171-5	2004	However, ACE2 also hydrolyses dynorphin A (1-13), apelin-13 and des-Arg(9) bradykinin.	des-arg	64-71	angiotensin converting enzyme 2	Homo sapiens	9-13
16008552-6	2005	The difference in chloride sensitivity between ACE2 and ACE was investigated, and the absence of a second chloride-binding site (CL2) in ACE2 confirmed.	Chlorine	129-132	angiotensin converting enzyme 2	Homo sapiens	137-141
16008552-7	2005	Thus ACE2 has only one chloride-binding site (CL1) whereas ACE has two sites.	Chlorides	23-31	angiotensin converting enzyme 2	Homo sapiens	5-9
16300161-3	2005	The writer was assigned by the Ministry of Health to Aceh on duty on the second and third week after the catastrophe, to help the management of Zainoel Abidin General Hospital in Banda Aceh, the province"s biggest hospital, revive its operation.	zainoel	144-151	angiotensin converting enzyme 2	Homo sapiens	53-57
16300161-3	2005	The writer was assigned by the Ministry of Health to Aceh on duty on the second and third week after the catastrophe, to help the management of Zainoel Abidin General Hospital in Banda Aceh, the province"s biggest hospital, revive its operation.	zainoel	144-151	angiotensin converting enzyme 2	Homo sapiens	185-189
15477383-6	2004	In conclusion, chronic atRA treatment increases gene and protein expressions of ACE2, resulting in the reduction of blood pressure and the attenuation of myocardial damage in SHR, which suggests that atRA may be an attractive candidate for the potential prevention and treatment of human essential hypertension.	Tretinoin	23-27	angiotensin converting enzyme 2	Homo sapiens	80-84
15477383-6	2004	In conclusion, chronic atRA treatment increases gene and protein expressions of ACE2, resulting in the reduction of blood pressure and the attenuation of myocardial damage in SHR, which suggests that atRA may be an attractive candidate for the potential prevention and treatment of human essential hypertension.	Tretinoin	200-204	angiotensin converting enzyme 2	Homo sapiens	80-84
15492138-5	2004	This approach identified N-(2-aminoethyl)-1 aziridine-ethanamine as a novel ACE2 inhibitor that also is effective in blocking the SARS coronavirus spike protein-mediated cell fusion.	N-(2-Aminoethyl)-1-aziridineethanamine	25-64	angiotensin converting enzyme 2	Homo sapiens	76-80
14609329-9	2003	The ACE2 model is also suggestive of a possible mechanism for chloride activation.	Chlorides	62-70	angiotensin converting enzyme 2	Homo sapiens	4-8
14670965-5	2004	A point mutation at aspartic acid 454 abolished association of the full S1 domain and of the 193-residue fragment with ACE2.	Aspartic Acid	20-33	angiotensin converting enzyme 2	Homo sapiens	119-123
14609329-0	2003	Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence.	Chlorides	111-119	angiotensin converting enzyme 2	Homo sapiens	0-31
14609329-10	2003	The structural insights provided by these analyses for the differences in inhibition pattern and substrate specificity among ACE and its homologue ACE2 and for the chloride dependence of ACE/ACE2 activity are valuable in understanding the function and regulation of ACE2.	Chlorides	164-172	angiotensin converting enzyme 2	Homo sapiens	191-195
14609329-0	2003	Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence.	Chlorides	111-119	angiotensin converting enzyme 2	Homo sapiens	33-37
14609329-10	2003	The structural insights provided by these analyses for the differences in inhibition pattern and substrate specificity among ACE and its homologue ACE2 and for the chloride dependence of ACE/ACE2 activity are valuable in understanding the function and regulation of ACE2.	Chlorides	164-172	angiotensin converting enzyme 2	Homo sapiens	191-195
12531198-2	2003	Using des-Arg bradykinin as a template, we designed a series of intramolecularly quenched fluorogenic peptide substrates for ACE2.	des-arg	6-13	angiotensin converting enzyme 2	Homo sapiens	125-129
14609329-6	2003	On the basis of the ability of ACE2 to cleave a variety of biologically active peptides, a consensus sequence of Pro-X-Pro-hydrophobic/basic for the protease specificity of ACE2 has been defined that is supported by the ACE2 model.	pro-x-pro	113-122	angiotensin converting enzyme 2	Homo sapiens	31-35
14609329-6	2003	On the basis of the ability of ACE2 to cleave a variety of biologically active peptides, a consensus sequence of Pro-X-Pro-hydrophobic/basic for the protease specificity of ACE2 has been defined that is supported by the ACE2 model.	pro-x-pro	113-122	angiotensin converting enzyme 2	Homo sapiens	173-177
14609329-6	2003	On the basis of the ability of ACE2 to cleave a variety of biologically active peptides, a consensus sequence of Pro-X-Pro-hydrophobic/basic for the protease specificity of ACE2 has been defined that is supported by the ACE2 model.	pro-x-pro	113-122	angiotensin converting enzyme 2	Homo sapiens	173-177
14609329-7	2003	The dipeptide, Pro-Phe, completely inhibits ACE2 activity at 180 microM with angiotensin II as the substrate.	Dipeptides	4-13	angiotensin converting enzyme 2	Homo sapiens	44-48
14609329-7	2003	The dipeptide, Pro-Phe, completely inhibits ACE2 activity at 180 microM with angiotensin II as the substrate.	H-Pro-Phe-OH	15-22	angiotensin converting enzyme 2	Homo sapiens	44-48
14609329-8	2003	As with ACE, the chloride dependence of ACE2 is substrate-specific such that the hydrolysis of angiotensin I and the synthetic peptide substrate, Mca-APK(Dnp), are activated in the presence of chloride ions, whereas the cleavage of angiotensin II is inhibited.	Chlorides	17-25	angiotensin converting enzyme 2	Homo sapiens	40-44
14609329-8	2003	As with ACE, the chloride dependence of ACE2 is substrate-specific such that the hydrolysis of angiotensin I and the synthetic peptide substrate, Mca-APK(Dnp), are activated in the presence of chloride ions, whereas the cleavage of angiotensin II is inhibited.	Chlorides	193-201	angiotensin converting enzyme 2	Homo sapiens	40-44
12531198-6	2003	Two of the optimized substrates, TBC5180 and TBC5182, produced a signal:noise ratio of better than 20 when hydrolyzed by ACE2.	tbc5180	33-40	angiotensin converting enzyme 2	Homo sapiens	121-125
12531198-6	2003	Two of the optimized substrates, TBC5180 and TBC5182, produced a signal:noise ratio of better than 20 when hydrolyzed by ACE2.	tbc5182	45-52	angiotensin converting enzyme 2	Homo sapiens	121-125
12531198-7	2003	Kinetic measurements with ACE2 were as follows: TBC5180, K(m)=58 microM and k(cat)/K(m)=1.3x10(5)M(-1)s(-1); TBC5182, K(m)=23 microM and k(cat)/K(m)=3.5 x 10(4)M(-1)s(-1).	tbc5180	48-55	angiotensin converting enzyme 2	Homo sapiens	26-30
12531198-7	2003	Kinetic measurements with ACE2 were as follows: TBC5180, K(m)=58 microM and k(cat)/K(m)=1.3x10(5)M(-1)s(-1); TBC5182, K(m)=23 microM and k(cat)/K(m)=3.5 x 10(4)M(-1)s(-1).	tbc5182	109-116	angiotensin converting enzyme 2	Homo sapiens	26-30
12914653-5	2003	Recently, an ACE homolog, ACE2, has been identified in humans that differs from ACE in being a carboxypeptidase that preferentially removes carboxy-terminal hydrophobic or basic amino acids; it appears to be important in cardiac function.	Amino Acids, Basic	172-189	angiotensin converting enzyme 2	Homo sapiens	26-30
10924499-5	2000	Expression in Chinese hamster ovary cells of a soluble, truncated form of ACEH, lacking the transmembrane and cytosolic domains, produces a glycoprotein of 120 kDa, which is able to cleave angiotensin I and angiotensin II but not bradykinin or Hip-His-Leu.	hip-his	244-251	angiotensin converting enzyme 2	Homo sapiens	74-78
11815627-9	2002	ACE2 also efficiently hydrolyzes des-Arg(9)-bradykinin (k(cat)/K(m) = 1.3 x 10(5) m(-1) s(-1)), but it does not hydrolyze bradykinin.	des-arg	33-40	angiotensin converting enzyme 2	Homo sapiens	0-4
11815627-10	2002	An alignment of the ACE2 peptide substrates reveals a consensus sequence of: Pro-X((1-3 residues))-Pro-Hydrophobic, where hydrolysis occurs between proline and the hydrophobic amino acid.	pro-x	77-82	angiotensin converting enzyme 2	Homo sapiens	20-24
11815627-10	2002	An alignment of the ACE2 peptide substrates reveals a consensus sequence of: Pro-X((1-3 residues))-Pro-Hydrophobic, where hydrolysis occurs between proline and the hydrophobic amino acid.	Proline	77-80	angiotensin converting enzyme 2	Homo sapiens	20-24
11815627-10	2002	An alignment of the ACE2 peptide substrates reveals a consensus sequence of: Pro-X((1-3 residues))-Pro-Hydrophobic, where hydrolysis occurs between proline and the hydrophobic amino acid.	Proline	148-155	angiotensin converting enzyme 2	Homo sapiens	20-24
10924499-5	2000	Expression in Chinese hamster ovary cells of a soluble, truncated form of ACEH, lacking the transmembrane and cytosolic domains, produces a glycoprotein of 120 kDa, which is able to cleave angiotensin I and angiotensin II but not bradykinin or Hip-His-Leu.	Leucine	252-255	angiotensin converting enzyme 2	Homo sapiens	74-78
10924499-7	2000	ACEH activity is inhibited by EDTA but not by classical ACE inhibitors such as captopril, lisinopril, or enalaprilat.	Edetic Acid	30-34	angiotensin converting enzyme 2	Homo sapiens	0-4
8767468-0	1996	ACAT/CEH and ACEH/LAL: two key enzymes in hepatic cellular cholesterol homeostasis and their involvement in genetic disorders.	Cholesterol	59-70	angiotensin converting enzyme 2	Homo sapiens	13-17
9461491-0	1998	A novel peptide-processing activity of insect peptidyl-dipeptidase A (angiotensin I-converting enzyme): the hydrolysis of lysyl-arginine and arginyl-arginine from the C-terminus of an insect prohormone peptide.	Lys-Arg	122-136	angiotensin converting enzyme 2	Homo sapiens	46-68
9461491-0	1998	A novel peptide-processing activity of insect peptidyl-dipeptidase A (angiotensin I-converting enzyme): the hydrolysis of lysyl-arginine and arginyl-arginine from the C-terminus of an insect prohormone peptide.	arginylarginine	141-157	angiotensin converting enzyme 2	Homo sapiens	46-68
10969042-7	2000	Recombinant ACE2 hydrolyzes the carboxy terminal leucine from angiotensin I to generate angiotensin 1-9, which is converted to smaller angiotensin peptides by ACE in vitro and by cardiomyocytes in culture.	Leucine	49-56	angiotensin converting enzyme 2	Homo sapiens	12-16
10969042-8	2000	ACE2 can also cleave des-Arg bradykinin and neurotensin but not bradykinin or 15 other vasoactive and hormonal peptides tested.	des-arg	21-28	angiotensin converting enzyme 2	Homo sapiens	0-4
33823179-6	2021	The spike and ACE2 proteins are highly glycosylated with sialic acid modifications that direct viral-host interactions and infection.	N-Acetylneuraminic Acid	57-68	angiotensin converting enzyme 2	Homo sapiens	14-18
33792947-7	2021	As an example of the latter, analyses of strepsirrhine primate ACE2 sequences to date indicate large variation among lemurs and lorises compared to other primate clades despite low sampling effort.	strepsirrhine	41-54	angiotensin converting enzyme 2	Homo sapiens	63-67
33769277-6	2021	SNVs in AGT (p = 0.0141), REN (p = 0.0192), and ACE2 (p = 0.0002) were found to be associated with successful treatment on lisinopril.	Lisinopril	123-133	angiotensin converting enzyme 2	Homo sapiens	48-52
33820835-4	2021	Biochemical, structural, and functional characterization of LY-CoV555 revealed high-affinity binding to the receptor-binding domain, angiotensin converting enzyme 2 binding inhibition, and potent neutralizing activity.	ly-cov555	60-69	angiotensin converting enzyme 2	Homo sapiens	133-164
33972944-8	2021	Strikingly, single daily intranasal administration of N-0385 early in infection significantly improved weight loss and clinical outcomes, and yielded 100% survival in the severe K18-human ACE2 transgenic mouse model of SARS-CoV-2 disease.	Ms-QFR-Kbt	54-60	angiotensin converting enzyme 2	Homo sapiens	188-192
33811809-7	2021	Additionally, BETi decreases transcription of genes in the viral response, decreases ACE2 expression, and reduces SARS-CoV-2 infection of cardiomyocytes.	beti	14-18	angiotensin converting enzyme 2	Homo sapiens	85-89
33821278-9	2021	Viruses pseudotyped with natural variants of the serine/threonine residues implicated in O-linked glycosylation were generally infectious and exhibited sensitivity to neutralization by soluble ACE2 and convalescent antisera comparable to that of the wild-type virus.	Serine	49-55	angiotensin converting enzyme 2	Homo sapiens	193-197
33821278-9	2021	Viruses pseudotyped with natural variants of the serine/threonine residues implicated in O-linked glycosylation were generally infectious and exhibited sensitivity to neutralization by soluble ACE2 and convalescent antisera comparable to that of the wild-type virus.	Threonine	56-65	angiotensin converting enzyme 2	Homo sapiens	193-197
33810129-11	2021	Microginins, the linear peptides, inhibit angiotensin-converting enzyme (ACE), therefore, their use in the treatment of COVID-19 patients with injury of the ACE2 expressing organs is considered.	microginins	0-11	angiotensin converting enzyme 2	Homo sapiens	157-161
33810568-2	2021	This work describes investigations of chitosan interaction with SARS-CoV-2, which is occupied by human respiratory epithelial cells through communication with the human angiotension-converting enzyme II (ACE2).	angiotension	169-181	angiotensin converting enzyme 2	Homo sapiens	204-208
33768439-5	2021	Many researchers have voiced concerns that the use of ACEIs and ARBs may increase tissue ACE2 levels.	aceis	54-59	angiotensin converting enzyme 2	Homo sapiens	89-93
33768439-10	2021	Further studies are required to investigate the effect of ACEIs and ARBs on ACE2 expression and COVID-19.	aceis	58-63	angiotensin converting enzyme 2	Homo sapiens	76-80
33815295-8	2021	Decreasing insulin resistance, reduction of some inflammatory cytokines like IL-6 and TNF-alpha, modulation of angiotensin-converting enzyme 2 (ACE2) receptor, and improving neutrophil to lymphocyte ratio are some of the potential mechanisms of metformin in COVID-19 patients with DM.	Metformin	245-254	angiotensin converting enzyme 2	Homo sapiens	111-142
33764894-7	2021	ACE2 cleaves lys-des-arginine9BK and arg-des-arginine9BK, the active metabolites of bradykinin, which stimulate the BKB1R receptor.	lys-des-arginine9bk	13-32	angiotensin converting enzyme 2	Homo sapiens	0-4
33764894-7	2021	ACE2 cleaves lys-des-arginine9BK and arg-des-arginine9BK, the active metabolites of bradykinin, which stimulate the BKB1R receptor.	arg-des-arginine9bk	37-56	angiotensin converting enzyme 2	Homo sapiens	0-4
33802256-8	2021	ACE2 gene expression was significantly increased in cells exposed to the locally bought e-liquid condensate with high nicotine concentration and cigarette smoke extract compared with cell controls.	Nicotine	118-126	angiotensin converting enzyme 2	Homo sapiens	0-4
33778258-12	2021	Human Cmax for pyronaridine and quinacrine is greater than the IC50 observed in A549-ACE2 cells.	pyronaridine	15-27	angiotensin converting enzyme 2	Homo sapiens	85-89
33815131-5	2021	Nicotine upregulates the expression of ACE2, which can also increase susceptibility to COVID-19, aggravatiing the disease.	Nicotine	0-8	angiotensin converting enzyme 2	Homo sapiens	39-43
34866721-6	2022	Graphene significantly affects the secondary structure of RBD area, especially on the three key sites of binding with human ACE2, GLY476, PHE486 and ASN487.	Graphite	0-8	angiotensin converting enzyme 2	Homo sapiens	124-128
33822495-6	2021	Additionally, we found that both betulinic acid and inonotusane C could bind and stably interact with the spike protein near the host cell recognition site of angiotensin-converting enzyme 2.	betulinic acid	33-47	angiotensin converting enzyme 2	Homo sapiens	159-190
33822495-6	2021	Additionally, we found that both betulinic acid and inonotusane C could bind and stably interact with the spike protein near the host cell recognition site of angiotensin-converting enzyme 2.	Inonotusane C	52-65	angiotensin converting enzyme 2	Homo sapiens	159-190
34480250-7	2022	MTx also rescued the diminished expression of ACE2 in CoV-2-SRBD transfected cells.	Methotrexate	0-3	angiotensin converting enzyme 2	Homo sapiens	46-50
34863742-4	2022	Despite lesser affinity towards COVID-19 virus, as compared to ACE2, this receptor provides a suitable justification behind elevated blood glucose levels in infected patients, retarded COVID-19 risk in women, enhanced susceptibility in geriatrics, greater infection susceptibility of T cells, infection prevalence in non-susceptible human cardiac pericytes and so on.	Glucose	139-146	angiotensin converting enzyme 2	Homo sapiens	63-67
34942397-10	2022	In addition to the well-known ACE2 inhibitors that were identified in previous studies, this study revealed for the first time that epicatechin from Hypericum perforatum provided a better static and dynamic inhibition for ACE2 with highly favourable pharmacokinetic properties than the other known ACE2 inhibiting compounds.	Catechin	132-143	angiotensin converting enzyme 2	Homo sapiens	30-34
34942397-10	2022	In addition to the well-known ACE2 inhibitors that were identified in previous studies, this study revealed for the first time that epicatechin from Hypericum perforatum provided a better static and dynamic inhibition for ACE2 with highly favourable pharmacokinetic properties than the other known ACE2 inhibiting compounds.	Catechin	132-143	angiotensin converting enzyme 2	Homo sapiens	222-226
34942397-12	2022	In vitro experiments are required to validate epicatechin effectiveness against the activity of the human ACE2 receptor.	Catechin	46-57	angiotensin converting enzyme 2	Homo sapiens	106-110
34427852-0	2022	Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.	Glycyrrhizic Acid	0-17	angiotensin converting enzyme 2	Homo sapiens	94-125
34427852-0	2022	Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.	Glycyrrhizic Acid	0-17	angiotensin converting enzyme 2	Homo sapiens	127-131
34848886-10	2022	The effect of viral binding to neuronal ACE2 in areas of the brain that regulate salt/water balance and blood pressure is also discussed in light of the neural regulation of hypertension in COVID-19.	Water	86-91	angiotensin converting enzyme 2	Homo sapiens	40-44
34955621-7	2022	The increase in the number of interface residues, interface area and intermolecular forces such as hydrogen bonds, salt bridges and non-bonded contacts corroborated with the increase in the binding affinity of the spike mutants to ACE2.	Hydrogen	99-107	angiotensin converting enzyme 2	Homo sapiens	231-235
34955621-8	2022	Further, 75 ns all-atom molecular dynamics simulation investigations show variations in the geometric properties such as root mean square deviation (RMSD), radius of gyration (Rg), total solvent accessible surface area (SASA) and number of hydrogen bonds (NHBs) in the mutant spike:ACE2 complexes with respect to the native spike:ACE2 complex.	Hydrogen	240-248	angiotensin converting enzyme 2	Homo sapiens	282-286
34968782-6	2022	The mutations at the ACE2-RBD interface enhance the tight binding by increasing hydrogen bonding interaction and enlarging buried solvent accessible surface area.	Hydrogen	80-88	angiotensin converting enzyme 2	Homo sapiens	21-25
34427852-5	2022	Our results showed that GA significantly attenuated LPS-induced ALI and decreased the production of inflammatory factors, including IL-1beta, MCP-1, COX2, HMGB1, and adhesion molecules, such as E-selectin, VCAM-1, and modulated expression of angiotensin-converting enzyme 2 (ACE2).	Glycyrrhizic Acid	24-26	angiotensin converting enzyme 2	Homo sapiens	242-273
34427852-5	2022	Our results showed that GA significantly attenuated LPS-induced ALI and decreased the production of inflammatory factors, including IL-1beta, MCP-1, COX2, HMGB1, and adhesion molecules, such as E-selectin, VCAM-1, and modulated expression of angiotensin-converting enzyme 2 (ACE2).	Glycyrrhizic Acid	24-26	angiotensin converting enzyme 2	Homo sapiens	275-279
34427852-6	2022	Moreover, treatment of ACE2 inhibitor (MLN-4760) reversed the effects of GA on the secretion of pro-inflammatory factors in ALI.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	39-47	angiotensin converting enzyme 2	Homo sapiens	23-27
34427852-6	2022	Moreover, treatment of ACE2 inhibitor (MLN-4760) reversed the effects of GA on the secretion of pro-inflammatory factors in ALI.	Glycyrrhizic Acid	73-75	angiotensin converting enzyme 2	Homo sapiens	23-27
34427852-7	2022	Additionally, GA exerts its protective effect by regulating the ACE2 and caveolin-1/NF-kappaB signaling pathway.	Glycyrrhizic Acid	14-16	angiotensin converting enzyme 2	Homo sapiens	64-68
34427852-8	2022	In conclusion, this study showed that GA alleviated LPS-induced ALI by upregulating ACE2 and inhibiting the caveolin-1/NF-kappaB signaling pathway.	Glycyrrhizic Acid	38-40	angiotensin converting enzyme 2	Homo sapiens	84-88
34780781-5	2022	This flexibility is particularly prominent for the disulfide bond-containing surface loop (residues 456-490) that participates in the formation of the interaction surface with the Spike cell receptor ACE2.	Disulfides	51-60	angiotensin converting enzyme 2	Homo sapiens	200-204
34780781-6	2022	In vitro, disulfide bond reducing agents affect the RBD secondary structure, lower its melting temperature from 52 C to 36-39 C and decrease its binding affinity to ACE2 by two orders of magnitude at 37 C. Consistent with these in vitro findings, the reducing agents tris(2-carboxyethyl)phosphine (TCEP) and dithiothreitol (DTT) were able to inhibit viral replication at low millimolar levels in cell-based assays.	Disulfides	10-19	angiotensin converting enzyme 2	Homo sapiens	165-169
34780781-6	2022	In vitro, disulfide bond reducing agents affect the RBD secondary structure, lower its melting temperature from 52 C to 36-39 C and decrease its binding affinity to ACE2 by two orders of magnitude at 37 C. Consistent with these in vitro findings, the reducing agents tris(2-carboxyethyl)phosphine (TCEP) and dithiothreitol (DTT) were able to inhibit viral replication at low millimolar levels in cell-based assays.	tris(2-carboxyethyl)phosphine	267-296	angiotensin converting enzyme 2	Homo sapiens	165-169
34780781-6	2022	In vitro, disulfide bond reducing agents affect the RBD secondary structure, lower its melting temperature from 52 C to 36-39 C and decrease its binding affinity to ACE2 by two orders of magnitude at 37 C. Consistent with these in vitro findings, the reducing agents tris(2-carboxyethyl)phosphine (TCEP) and dithiothreitol (DTT) were able to inhibit viral replication at low millimolar levels in cell-based assays.	tris(2-carboxyethyl)phosphine	298-302	angiotensin converting enzyme 2	Homo sapiens	165-169
34780781-6	2022	In vitro, disulfide bond reducing agents affect the RBD secondary structure, lower its melting temperature from 52 C to 36-39 C and decrease its binding affinity to ACE2 by two orders of magnitude at 37 C. Consistent with these in vitro findings, the reducing agents tris(2-carboxyethyl)phosphine (TCEP) and dithiothreitol (DTT) were able to inhibit viral replication at low millimolar levels in cell-based assays.	Dithiothreitol	308-322	angiotensin converting enzyme 2	Homo sapiens	165-169
34780781-6	2022	In vitro, disulfide bond reducing agents affect the RBD secondary structure, lower its melting temperature from 52 C to 36-39 C and decrease its binding affinity to ACE2 by two orders of magnitude at 37 C. Consistent with these in vitro findings, the reducing agents tris(2-carboxyethyl)phosphine (TCEP) and dithiothreitol (DTT) were able to inhibit viral replication at low millimolar levels in cell-based assays.	Dithiothreitol	324-327	angiotensin converting enzyme 2	Homo sapiens	165-169
34965734-4	2022	Although high levels of reactive oxygen and nitrogen species (RONS) are produced during viral infections, it is not clear how they affect the RBD structure and its binding to ACE2 and GRP78.	Nitrogen	44-52	angiotensin converting enzyme 2	Homo sapiens	175-179
34246414-4	2022	Because it is modular, the assay can monitor the impact of different cellular components, such as heparan sulfate, lipids, and membrane proteins on the RBD-ACE2 interaction and it can be extended to the full-length spike protein.	Heparitin Sulfate	98-113	angiotensin converting enzyme 2	Homo sapiens	156-160
34928574-4	2022	This facilitates the subsequent interaction with the cellular glycosaminoglycans through the S1B domain of the spike protein as it binds to the ACE2 receptor.	Glycosaminoglycans	62-80	angiotensin converting enzyme 2	Homo sapiens	144-148
34914393-0	2022	Discovery of Bile Acid Derivatives as Potent ACE2 Activators by Virtual Screening and Essential Dynamics.	Bile Acids and Salts	13-22	angiotensin converting enzyme 2	Homo sapiens	45-49
34914393-6	2022	Here, using a combined in silico and experimental approach, we show that ursodeoxycholic acid (UDCA) derivatives work as ACE2 activators.	Ursodeoxycholic Acid	73-93	angiotensin converting enzyme 2	Homo sapiens	121-125
34914393-6	2022	Here, using a combined in silico and experimental approach, we show that ursodeoxycholic acid (UDCA) derivatives work as ACE2 activators.	Ursodeoxycholic Acid	95-99	angiotensin converting enzyme 2	Homo sapiens	121-125
34914393-7	2022	In detail, we have identified two potent ACE2 ligands, BAR107 and BAR708, through a docking virtual screening campaign and elucidated their mechanism of action from essential dynamics of the enzyme observed during microsecond molecular dynamics calculations.	bar107	55-61	angiotensin converting enzyme 2	Homo sapiens	41-45
34914393-7	2022	In detail, we have identified two potent ACE2 ligands, BAR107 and BAR708, through a docking virtual screening campaign and elucidated their mechanism of action from essential dynamics of the enzyme observed during microsecond molecular dynamics calculations.	bar708	66-72	angiotensin converting enzyme 2	Homo sapiens	41-45
34965734-4	2022	Although high levels of reactive oxygen and nitrogen species (RONS) are produced during viral infections, it is not clear how they affect the RBD structure and its binding to ACE2 and GRP78.	rons	62-66	angiotensin converting enzyme 2	Homo sapiens	175-179
34914393-8	2022	The in silico results were confirmed by in vitro pharmacological assays with the newly identified compounds showing ACE2 activity comparable to that of DIZE, the most potent ACE2 activator known so far.	dize	152-156	angiotensin converting enzyme 2	Homo sapiens	174-178
34965734-5	2022	In this research, we apply molecular dynamics simulations to study the effect of oxidation of the highly reactive cysteine (Cys) amino acids of the RBD on its binding to ACE2 and GRP78.	cysteine (cys) amino acids	114-140	angiotensin converting enzyme 2	Homo sapiens	170-174
34883069-0	2022	SARS-Cov-2 Spike binding to ACE2 is stronger and longer ranged due to glycan interaction.	Polysaccharides	70-76	angiotensin converting enzyme 2	Homo sapiens	28-32
34483364-6	2022	In the current study, the resulted scores from molecular docking and dynamics simulations as the primary determinative factor as well as the observed reliable binding modes have demonstrated that Nicotinamide Riboside and its active metabolite NMN can target human ACE2 and IMPDH, along with the viral Spro, Mpro, PLpro, and on top of all, RdRp as a potential competitive inhibitor.	nicotinamide-beta-riboside	196-217	angiotensin converting enzyme 2	Homo sapiens	265-269
34729910-10	2022	S-hydroxychloroquine showed better ACE2 receptor binding ability than R-hydroxychloroquine/hydroxychloroquine (racemate), while the effect of preventing SARS-CoV-2 pseudovirus from entering cells was weaker than R-hydroxychloroquine/hydroxychloroquine (racemate).	racemate	111-119	angiotensin converting enzyme 2	Homo sapiens	35-39
34826419-0	2022	Hydroxychloroquine treatment on SARS-CoV-2 receptor ACE2, TMPRSS2 and NRP1 expression in human primary pterygium and conjunctival cells.	Hydroxychloroquine	0-18	angiotensin converting enzyme 2	Homo sapiens	52-56
34826419-7	2022	ACE2 protein expression was significantly decreased in both pterygium and conjunctival cells after hydroxychloroquine treatment.	Hydroxychloroquine	99-117	angiotensin converting enzyme 2	Homo sapiens	0-4
34826419-11	2022	In summary, this study revealed the reduction of ACE2 and NRP1 expression by hydroxychloroquine in human primary pterygium and conjunctival fibroblasts; yet with the increase in TMPRSS2 expression and oxidative stress and decrease in cell viability.	Hydroxychloroquine	77-95	angiotensin converting enzyme 2	Homo sapiens	49-53
34915409-5	2022	The higher binding affinity of the E484K mutant is caused due to the formation of additional hydrogen bond and salt-bridge interactions with ACE2.	Hydrogen	93-101	angiotensin converting enzyme 2	Homo sapiens	141-145
34729910-0	2022	Investigating of interactions between chloroquine/hydroxychloroquine and their single enantiomers and angiotensin-converting enzyme 2 by a cell membrane chromatography method.	Chloroquine	38-49	angiotensin converting enzyme 2	Homo sapiens	102-133
34729910-0	2022	Investigating of interactions between chloroquine/hydroxychloroquine and their single enantiomers and angiotensin-converting enzyme 2 by a cell membrane chromatography method.	Hydroxychloroquine	50-68	angiotensin converting enzyme 2	Homo sapiens	102-133
34725529-8	2022	As indicated by the results, although all introduced COFs deformed the spike protein in an effective way, COF-78 showed the best performance in the prevention of spike protein-ACE2 interactions by changing the molecular structure of the protein.	cof-78	106-112	angiotensin converting enzyme 2	Homo sapiens	176-180
34742404-4	2022	Further, we show that homogeneous polysaccharide 37502 from the 375 may bind to 3CLpro well and disturb spike protein binding to ACE2 receptor.	Polysaccharides	34-48	angiotensin converting enzyme 2	Homo sapiens	129-133
34815622-4	2022	Epigallocatechin-3-gallate - a polyphenol from tea - effectively has been shown to inhibit the activity of SARS-CoV-2 as it blocked binding of coronavirus 2 to human angiotensin converting enzyme 2, decreased the expression of inflammatory factors in the blood, including tumor necrosis factor-alpha and interleukin-6, and significantly increased the overall fertilization efficiency in animals.	epigallocatechin gallate	0-26	angiotensin converting enzyme 2	Homo sapiens	166-197
34815622-4	2022	Epigallocatechin-3-gallate - a polyphenol from tea - effectively has been shown to inhibit the activity of SARS-CoV-2 as it blocked binding of coronavirus 2 to human angiotensin converting enzyme 2, decreased the expression of inflammatory factors in the blood, including tumor necrosis factor-alpha and interleukin-6, and significantly increased the overall fertilization efficiency in animals.	Polyphenols	31-41	angiotensin converting enzyme 2	Homo sapiens	166-197
34586649-0	2022	Therapeutic potential of melatonin and melatonergic drugs on K18-hACE2 mice infected with SARS-CoV-2.	Melatonin	25-34	angiotensin converting enzyme 2	Homo sapiens	65-70
34800514-0	2022	Impact of the ACE2 activator xanthenone on tacrolimus nephrotoxicity: Modulation of uric acid/ERK/p38 MAPK and Nrf2/SOD3/GCLC signaling pathways.	xanthone	29-39	angiotensin converting enzyme 2	Homo sapiens	14-18
34800514-0	2022	Impact of the ACE2 activator xanthenone on tacrolimus nephrotoxicity: Modulation of uric acid/ERK/p38 MAPK and Nrf2/SOD3/GCLC signaling pathways.	Tacrolimus	43-53	angiotensin converting enzyme 2	Homo sapiens	14-18
34800514-0	2022	Impact of the ACE2 activator xanthenone on tacrolimus nephrotoxicity: Modulation of uric acid/ERK/p38 MAPK and Nrf2/SOD3/GCLC signaling pathways.	Uric Acid	84-93	angiotensin converting enzyme 2	Homo sapiens	14-18
34800514-4	2022	Our study was designed to investigate effects of the ACE2 activator xanthenone on tacrolimus-induced renal injury.	xanthone	68-78	angiotensin converting enzyme 2	Homo sapiens	53-57
34800514-10	2022	SIGNIFICANCE: These protective effects of xanthenone could be attributed to ANG II degradation to ANG (1-7) by ACE2 activation resulting in regulated inflammatory and oxidative responses in the kidney.	xanthone	42-52	angiotensin converting enzyme 2	Homo sapiens	111-115
34561887-5	2022	The viral particle incorporates the S protein, which has already undergone S1/S2 cleavage by furin, and then undergoes further cleavage at the S2" site, mediated by the type II transmembrane serine protease TMPRSS2, after binding to the receptor ACE2 to facilitate membrane fusion at the plasma membrane.	Serine	191-197	angiotensin converting enzyme 2	Homo sapiens	246-250
34729910-5	2022	R-chloroquine showed better ACE2 receptor binding ability compared to S-chloroquine/chloroquine (racemate).	r-chloroquine	0-13	angiotensin converting enzyme 2	Homo sapiens	28-32
34729910-5	2022	R-chloroquine showed better ACE2 receptor binding ability compared to S-chloroquine/chloroquine (racemate).	Chloroquine	70-83	angiotensin converting enzyme 2	Homo sapiens	28-32
34729910-5	2022	R-chloroquine showed better ACE2 receptor binding ability compared to S-chloroquine/chloroquine (racemate).	Chloroquine	84-95	angiotensin converting enzyme 2	Homo sapiens	28-32
34729910-6	2022	S-hydroxychloroquine showed better ACE2 receptor binding ability than R-hydroxychloroquine/hydroxychloroquine.	Hydroxychloroquine	0-20	angiotensin converting enzyme 2	Homo sapiens	35-39
34729910-6	2022	S-hydroxychloroquine showed better ACE2 receptor binding ability than R-hydroxychloroquine/hydroxychloroquine.	Hydroxychloroquine	70-90	angiotensin converting enzyme 2	Homo sapiens	35-39
34961411-5	2021	The molecules 5-O-Feruloyl-quinic acid, 3-Caffeoyl-quinic acid, 5-O-Coumaroyl-D-quinic acid, Epicatechin and Catechin showed promising binding affinity with SARS-CoV-2 Main protease (MPro; PDB ID: 6LU7; responsible for viral replication) and Human Angiotensin Converting Enzyme-2 (ACE2; PDB ID: 1R4L; mediate viral entry in the host).	5-o-feruloyl-quinic acid	14-38	angiotensin converting enzyme 2	Homo sapiens	281-285
34729910-6	2022	S-hydroxychloroquine showed better ACE2 receptor binding ability than R-hydroxychloroquine/hydroxychloroquine.	Hydroxychloroquine	91-109	angiotensin converting enzyme 2	Homo sapiens	35-39
34729910-9	2022	In conclusion, R-chloroquine showed better ACE2 receptor binding ability and inhibitory effects compared to S-chloroquine/chloroquine (racemate).	r-chloroquine	15-28	angiotensin converting enzyme 2	Homo sapiens	43-47
34729910-9	2022	In conclusion, R-chloroquine showed better ACE2 receptor binding ability and inhibitory effects compared to S-chloroquine/chloroquine (racemate).	Chloroquine	108-121	angiotensin converting enzyme 2	Homo sapiens	43-47
34729910-9	2022	In conclusion, R-chloroquine showed better ACE2 receptor binding ability and inhibitory effects compared to S-chloroquine/chloroquine (racemate).	Chloroquine	122-133	angiotensin converting enzyme 2	Homo sapiens	43-47
34729910-10	2022	S-hydroxychloroquine showed better ACE2 receptor binding ability than R-hydroxychloroquine/hydroxychloroquine (racemate), while the effect of preventing SARS-CoV-2 pseudovirus from entering cells was weaker than R-hydroxychloroquine/hydroxychloroquine (racemate).	Hydroxychloroquine	0-20	angiotensin converting enzyme 2	Homo sapiens	35-39
34729910-10	2022	S-hydroxychloroquine showed better ACE2 receptor binding ability than R-hydroxychloroquine/hydroxychloroquine (racemate), while the effect of preventing SARS-CoV-2 pseudovirus from entering cells was weaker than R-hydroxychloroquine/hydroxychloroquine (racemate).	Hydroxychloroquine	70-90	angiotensin converting enzyme 2	Homo sapiens	35-39
34729910-10	2022	S-hydroxychloroquine showed better ACE2 receptor binding ability than R-hydroxychloroquine/hydroxychloroquine (racemate), while the effect of preventing SARS-CoV-2 pseudovirus from entering cells was weaker than R-hydroxychloroquine/hydroxychloroquine (racemate).	Hydroxychloroquine	91-109	angiotensin converting enzyme 2	Homo sapiens	35-39
34972763-2	2021	Medications that affect ACE2 expression or function such as angiotensin receptor blockers (ARBs) and ACE inhibitors (ACE-I) and metformin have the potential to counter the dysregulation of ACE2 by the virus and protect against viral injury.	Metformin	128-137	angiotensin converting enzyme 2	Homo sapiens	24-28
34972763-2	2021	Medications that affect ACE2 expression or function such as angiotensin receptor blockers (ARBs) and ACE inhibitors (ACE-I) and metformin have the potential to counter the dysregulation of ACE2 by the virus and protect against viral injury.	Metformin	128-137	angiotensin converting enzyme 2	Homo sapiens	189-193
34961411-5	2021	The molecules 5-O-Feruloyl-quinic acid, 3-Caffeoyl-quinic acid, 5-O-Coumaroyl-D-quinic acid, Epicatechin and Catechin showed promising binding affinity with SARS-CoV-2 Main protease (MPro; PDB ID: 6LU7; responsible for viral replication) and Human Angiotensin Converting Enzyme-2 (ACE2; PDB ID: 1R4L; mediate viral entry in the host).	Catechin	109-117	angiotensin converting enzyme 2	Homo sapiens	248-279
34961411-5	2021	The molecules 5-O-Feruloyl-quinic acid, 3-Caffeoyl-quinic acid, 5-O-Coumaroyl-D-quinic acid, Epicatechin and Catechin showed promising binding affinity with SARS-CoV-2 Main protease (MPro; PDB ID: 6LU7; responsible for viral replication) and Human Angiotensin Converting Enzyme-2 (ACE2; PDB ID: 1R4L; mediate viral entry in the host).	Catechin	109-117	angiotensin converting enzyme 2	Homo sapiens	281-285
34976549-2	2021	Proxalutamide is a second-generation, non-steroidal antiandrogen (NSAA) with the highest antiandrogen potency among NSAAs and concurrent regulation of angiotensin-converting enzyme 2 (ACE2) expression and inflammatory response.	proxalutamide	0-13	angiotensin converting enzyme 2	Homo sapiens	151-182
34976549-2	2021	Proxalutamide is a second-generation, non-steroidal antiandrogen (NSAA) with the highest antiandrogen potency among NSAAs and concurrent regulation of angiotensin-converting enzyme 2 (ACE2) expression and inflammatory response.	proxalutamide	0-13	angiotensin converting enzyme 2	Homo sapiens	184-188
34931597-4	2021	Supplements such as quercetin and beta glucan (beta-glucan) were the top docked compounds to ACE2 receptor though they strongly interacted with CoV target protein.	Quercetin	20-29	angiotensin converting enzyme 2	Homo sapiens	93-97
34937861-0	2021	Correlation of ACE2 with RAS components after Losartan treatment in light of COVID-19.	Losartan	46-54	angiotensin converting enzyme 2	Homo sapiens	15-19
34931597-4	2021	Supplements such as quercetin and beta glucan (beta-glucan) were the top docked compounds to ACE2 receptor though they strongly interacted with CoV target protein.	beta-Glucans	34-45	angiotensin converting enzyme 2	Homo sapiens	93-97
34931597-4	2021	Supplements such as quercetin and beta glucan (beta-glucan) were the top docked compounds to ACE2 receptor though they strongly interacted with CoV target protein.	beta-Glucans	47-58	angiotensin converting enzyme 2	Homo sapiens	93-97
34975483-3	2021	Here, I investigated the effect of an antidepressant drug fluvoxamine on membrane trafficking of the SARS-CoV-2 spike protein and its cell host receptor ACE2 in HEK293T cells.	Fluvoxamine	58-69	angiotensin converting enzyme 2	Homo sapiens	153-157
34927585-6	2021	Importantly, simultaneous removal of all accessible N-glycans from recombinant soluble human ACE2 yields a superior SARS-CoV-2 decoy receptor with promise as effective treatment for COVID-19 patients.	n-glycans	52-61	angiotensin converting enzyme 2	Homo sapiens	93-97
34927793-3	2022	Taking advantage of detailed epitope mapping, we generate two biparatopic Nbs (bipNbs) targeting a conserved epitope outside and two different epitopes inside the RBD:ACE2 interface.	bipnbs	79-85	angiotensin converting enzyme 2	Homo sapiens	167-171
34714566-3	2021	Based on previous results, we have selected more than 100 structurally diverse metal complexes for a profiling as inhibitors of two relevant SARS-CoV-2 replication mechanisms, namely the interaction of the spike protein with the ACE2 receptor and the papain-like protease PL pro .	Metals	79-84	angiotensin converting enzyme 2	Homo sapiens	229-233
34714566-5	2021	Among the mononuclear metal complexes, only a small number of active inhibitors of the spike/ACE2 interaction was identified, with titanocene dichloride as the only strong inhibitor.	Metals	22-27	angiotensin converting enzyme 2	Homo sapiens	93-97
34714566-5	2021	Among the mononuclear metal complexes, only a small number of active inhibitors of the spike/ACE2 interaction was identified, with titanocene dichloride as the only strong inhibitor.	titanocene dichloride	131-152	angiotensin converting enzyme 2	Homo sapiens	93-97
34975483-4	2021	A sub-therapeutic concentration (80 nM) of fluvoxamine rapidly upregulated fluid-phase endocytosis, resulting in enhanced accumulation of the spike-ACE2 complex in enlarged early endosomes.	Fluvoxamine	43-54	angiotensin converting enzyme 2	Homo sapiens	148-152
34975904-5	2021	In this review, we discussed the novel evidence on the cholesterol-rich lipid rafts as a platform for SARS-CoV-2 entry, where receptors such as the angiotensin-converting enzyme-2 (ACE-2), heparan sulfate proteoglycans (HSPGs), human Toll-like receptors (TLRs), transmembrane serine proteases (TMPRSS), CD-147 and HDL-scavenger receptor B type 1 (SR-B1) are recruited for their interaction with the viral spike protein.	Cholesterol	55-66	angiotensin converting enzyme 2	Homo sapiens	148-179
34896453-5	2022	Through screening by molecular docking, Oleanolic acid, Tryptanthrin, Chrysophanol and Rhein were found to have better spike protein and ACE2 inhibitory activity, which could block the invasion and recognition of SARS-CoV-2 at the same time, should be investigated as antiviral candidates.	Oleanolic Acid	40-54	angiotensin converting enzyme 2	Homo sapiens	137-141
34628234-7	2021	Based on this, the molecular structures of SARS-CoV-2 and ACE2 and their processes in the life cycle of SARS-CoV-2 and host cell infection were firstly reviewed in this paper, with emphasis on the methods and techniques of screening S protein-ACE2 blockers, including Virtual Screening (VS), Surface Plasmon Resonance (SPR), Biochromatography, Biotin-avidin with Enzyme-linked Immunosorbent assay and Gene Chip Technology.	Biotin	344-350	angiotensin converting enzyme 2	Homo sapiens	58-62
34914115-5	2022	We used computational studies to examine the Delta and Omicron variants in this work and found that the Omicron variant had a higher affinity for human ACE2 than the Delta variant due to a significant number of mutations in the SARS-CoV-2 receptor binding domain, indicating a higher potential for transmission.	delta	45-50	angiotensin converting enzyme 2	Homo sapiens	152-156
34956606-3	2022	For instance, upon the initial attachment, the receptor binding domain of the S protein forms primarily hydrogen bonds with the protease domain of ACE2 resulting in conformational changes within the secondary structure.	Hydrogen	104-112	angiotensin converting enzyme 2	Homo sapiens	147-151
34896453-5	2022	Through screening by molecular docking, Oleanolic acid, Tryptanthrin, Chrysophanol and Rhein were found to have better spike protein and ACE2 inhibitory activity, which could block the invasion and recognition of SARS-CoV-2 at the same time, should be investigated as antiviral candidates.	tryptanthrine	56-68	angiotensin converting enzyme 2	Homo sapiens	137-141
34896453-5	2022	Through screening by molecular docking, Oleanolic acid, Tryptanthrin, Chrysophanol and Rhein were found to have better spike protein and ACE2 inhibitory activity, which could block the invasion and recognition of SARS-CoV-2 at the same time, should be investigated as antiviral candidates.	chrysophanic acid	70-82	angiotensin converting enzyme 2	Homo sapiens	137-141
34947999-7	2021	Here, we demonstrate by using a SARS-CoV-2 spike pseudotyped lentivirus particles (SSPL) system and patient-isolated SARS-CoV-2 VOCs to infect transgenic A549ACE2/TMPRSS2 and Calu-3 human lung cells that all three carrageenan types exert antiviral activity.	Carrageenan	214-225	angiotensin converting enzyme 2	Homo sapiens	158-162
34950134-7	2021	Results: Imiquimod reduced ACE2 expression at baseline and after poly(I:C) stimulation.	Imiquimod	9-18	angiotensin converting enzyme 2	Homo sapiens	27-31
34293137-2	2021	ACE2 and TMPRSS2, host molecules required for viral entry, are regulated by sex steroids and expressed in the placenta.	Steroids	80-88	angiotensin converting enzyme 2	Homo sapiens	0-4
34950134-7	2021	Results: Imiquimod reduced ACE2 expression at baseline and after poly(I:C) stimulation.	Poly I-C	65-74	angiotensin converting enzyme 2	Homo sapiens	27-31
34950134-12	2021	Conclusion: Imiquimod triggers viral resistance mechanisms in HBECs by decreasing ACE2 and increasing IFN-beta expression.	Imiquimod	12-21	angiotensin converting enzyme 2	Homo sapiens	82-86
34402717-0	2021	Resveratrol supplementation reduces ACE2 expression in human adipose tissue.	Resveratrol	0-11	angiotensin converting enzyme 2	Homo sapiens	36-40
34901357-4	2021	The first is competitive inhibition of the SARS-CoV-2 spike glycoprotein (SGP) trimer binding to its human angiotensin converting enzyme 2 (ACE2) receptor by unfractionated heparin (UFH).	Heparin	173-180	angiotensin converting enzyme 2	Homo sapiens	107-138
34901357-4	2021	The first is competitive inhibition of the SARS-CoV-2 spike glycoprotein (SGP) trimer binding to its human angiotensin converting enzyme 2 (ACE2) receptor by unfractionated heparin (UFH).	Heparin	173-180	angiotensin converting enzyme 2	Homo sapiens	140-144
34901357-4	2021	The first is competitive inhibition of the SARS-CoV-2 spike glycoprotein (SGP) trimer binding to its human angiotensin converting enzyme 2 (ACE2) receptor by unfractionated heparin (UFH).	Heparin	182-185	angiotensin converting enzyme 2	Homo sapiens	107-138
34901357-4	2021	The first is competitive inhibition of the SARS-CoV-2 spike glycoprotein (SGP) trimer binding to its human angiotensin converting enzyme 2 (ACE2) receptor by unfractionated heparin (UFH).	Heparin	182-185	angiotensin converting enzyme 2	Homo sapiens	140-144
34901826-4	2021	In addition, we observed that the double mutated structure induced a significant change in the salt-bridge electrostatic interaction between RBD-T500 and ACE2-D355.	Salts	95-99	angiotensin converting enzyme 2	Homo sapiens	154-158
34901826-4	2021	In addition, we observed that the double mutated structure induced a significant change in the salt-bridge electrostatic interaction between RBD-T500 and ACE2-D355.	rbd-t500	141-149	angiotensin converting enzyme 2	Homo sapiens	154-158
34938305-8	2021	The half maximal inhibitory concentration (IC50) values of glycosylated ACE2 (gACE2) and deglycosylated ACE2 (dACE2) were ~1.0 and 8.48 mug/ml, respectively, for the pre-entry infection, when incubated with 100TCID50 of SARS-CoV-2.	gace2	78-83	angiotensin converting enzyme 2	Homo sapiens	72-76
34876760-4	2022	Polyunsaturated fatty acids control protein complex formation in lipid rafts associated with the function of two SARS-CoV-2 entry gateways: angiotensin-converting enzyme-2 and cellular protease transmembrane protease serine-2.	Fatty Acids, Unsaturated	0-27	angiotensin converting enzyme 2	Homo sapiens	140-171
34402717-3	2021	Although rodent and cell studies suggest that the polyphenol resveratrol alters ACE2, human studies are lacking.	Resveratrol	61-72	angiotensin converting enzyme 2	Homo sapiens	80-84
34402717-5	2021	Resveratrol markedly decreased ACE2 (~40%) and leptin (~30%), but did neither alter angiotensinogen, ACE and AT1R expression in AT nor skeletal muscle RAS components.	Resveratrol	0-11	angiotensin converting enzyme 2	Homo sapiens	31-35
34402717-6	2021	These findings demonstrate that resveratrol supplementation reduces ACE2 in AT, which might dampen SARS-CoV-2 spread in COVID-19.	Resveratrol	32-43	angiotensin converting enzyme 2	Homo sapiens	68-72
34227905-4	2021	The results showed that the full-length ACE2 gene in tree shrews was 2,786 bp, and its CDS was 2,418 bp, encoding 805 amino acids.	Cadmium	87-90	angiotensin converting enzyme 2	Homo sapiens	40-44
34514615-3	2021	Our goal was to analyse differences in ACE-2 expression in testicles of trans-women taking oestrogen or oestrogen +progesterone.	Progesterone	115-127	angiotensin converting enzyme 2	Homo sapiens	39-44
34514615-9	2021	On immunohistochemistry staining for Leydig cells and ACE-2 staining, the oestrogen+progesterone cohort had fewer Leydig cells compared with controls.	Progesterone	84-96	angiotensin converting enzyme 2	Homo sapiens	54-59
34514615-11	2021	This work supports the hopeful possibility that a short course of progesterone (or oestrogen+progesterone) could downregulate ACE-2 to protect men from COVID-19 infection.	Progesterone	66-78	angiotensin converting enzyme 2	Homo sapiens	126-131
34514615-11	2021	This work supports the hopeful possibility that a short course of progesterone (or oestrogen+progesterone) could downregulate ACE-2 to protect men from COVID-19 infection.	Progesterone	93-105	angiotensin converting enzyme 2	Homo sapiens	126-131
34389380-8	2021	Molecular modeling experiments revealed N501Y-specific stacking interactions in the RBD-ACE2 complex and provided insight into EGCG interference with the complex formation.	epigallocatechin gallate	127-131	angiotensin converting enzyme 2	Homo sapiens	88-92
34611521-3	2021	Recombinant human ACE2 (rhACE2) functionalized onto the surface of cytomimetic particles binds the receptor binding domain (RBD) of recombinant SARS-CoV-2 spike protein with high affinity and demonstrated a stoichiometric advantage over the use of soluble rhACE2.	rhace2	24-30	angiotensin converting enzyme 2	Homo sapiens	18-22
34667599-4	2021	Angiotensin-converting enzyme 2 is an essential component of the renin-angiotensin-aldosterone system and the target receptor that mediates SARS-CoV-2 entry to the cell.	Aldosterone	83-94	angiotensin converting enzyme 2	Homo sapiens	0-31
34667599-5	2021	This led to speculations that major renin-angiotensin-aldosterone system inhibitors, such as angiotensin receptor blockers and angiotensin-converting enzyme inhibitors might affect the course of the disease, since their administration enhances angiotensin-converting enzyme (ACE)2 expression.	Aldosterone	54-65	angiotensin converting enzyme 2	Homo sapiens	275-280
34227905-5	2021	Phylogenetic analysis based on the CDS of ACE2 revealed that tree shrews were more similar to rabbits (85.93%) and humans (85.47%) but far from mice (82.81%) and rats (82.58%).	Cadmium	35-38	angiotensin converting enzyme 2	Homo sapiens	42-46
34538222-8	2021	Importantly, vaccination with peptide 446-480 or with a cyclic version of peptide 446-488 containing a disulfide bridge between cysteines 480 and 488, protected humanized K18-hACE2 mice from a lethal dose of SARS-CoV-2 (62.5 and 75% of protection; P<0.01 and P<0.001, respectively).	Disulfides	103-112	angiotensin converting enzyme 2	Homo sapiens	175-180
34538222-8	2021	Importantly, vaccination with peptide 446-480 or with a cyclic version of peptide 446-488 containing a disulfide bridge between cysteines 480 and 488, protected humanized K18-hACE2 mice from a lethal dose of SARS-CoV-2 (62.5 and 75% of protection; P<0.01 and P<0.001, respectively).	Cysteine	128-137	angiotensin converting enzyme 2	Homo sapiens	175-180
34890039-6	2021	Bioinformatic docking studies showed that alpha-cyclodextrin and hydroxytyrosol, alone or in combination, interact with the viral spike protein and its host cell receptor ACE2, thereby potentially influencing the endocytosis process.	alpha-cyclodextrin	42-60	angiotensin converting enzyme 2	Homo sapiens	171-175
34839261-9	2021	FINDINGS: The receptor binding domain and three distinct SARS-CoV-2 surface N-glycosylation sites among 57,311 spike proteins retrieved from the NCBI-Virus-database are highly evolutionarily conserved (99.67%) and are involved in ACE2 interaction.	Nitrogen	76-77	angiotensin converting enzyme 2	Homo sapiens	230-234
34890039-6	2021	Bioinformatic docking studies showed that alpha-cyclodextrin and hydroxytyrosol, alone or in combination, interact with the viral spike protein and its host cell receptor ACE2, thereby potentially influencing the endocytosis process.	3,4-dihydroxyphenylethanol	65-79	angiotensin converting enzyme 2	Homo sapiens	171-175
34806090-3	2021	The binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) leads to deregulation of the renin-angiotensin-aldosterone system (RAAS) through down-regulation of ACE2 with subsequent increment of the harmful Ang II serum levels and reduction of the protective Ang-(1-7).	Aldosterone	119-130	angiotensin converting enzyme 2	Homo sapiens	33-64
34538460-9	2021	hCG increased the expression of ACE2 in primary hGLC cultures; the increase was inhibited by RU486 (an antagonist for progesterone receptor and glucocorticoid receptor) and CORT125281 (a selective glucocorticoid receptor antagonist), but not by AG1478 (an EGF receptor tyrosine kinase inhibitor) or by dexamethasone.	Mifepristone	93-98	angiotensin converting enzyme 2	Homo sapiens	32-36
34538460-9	2021	hCG increased the expression of ACE2 in primary hGLC cultures; the increase was inhibited by RU486 (an antagonist for progesterone receptor and glucocorticoid receptor) and CORT125281 (a selective glucocorticoid receptor antagonist), but not by AG1478 (an EGF receptor tyrosine kinase inhibitor) or by dexamethasone.	Exicorilant	173-183	angiotensin converting enzyme 2	Homo sapiens	32-36
34806090-3	2021	The binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) leads to deregulation of the renin-angiotensin-aldosterone system (RAAS) through down-regulation of ACE2 with subsequent increment of the harmful Ang II serum levels and reduction of the protective Ang-(1-7).	Aldosterone	119-130	angiotensin converting enzyme 2	Homo sapiens	66-70
34806090-3	2021	The binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) leads to deregulation of the renin-angiotensin-aldosterone system (RAAS) through down-regulation of ACE2 with subsequent increment of the harmful Ang II serum levels and reduction of the protective Ang-(1-7).	Aldosterone	119-130	angiotensin converting enzyme 2	Homo sapiens	172-176
34806090-3	2021	The binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) leads to deregulation of the renin-angiotensin-aldosterone system (RAAS) through down-regulation of ACE2 with subsequent increment of the harmful Ang II serum levels and reduction of the protective Ang-(1-7).	Angiotensin II	218-224	angiotensin converting enzyme 2	Homo sapiens	33-64
34806090-3	2021	The binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) leads to deregulation of the renin-angiotensin-aldosterone system (RAAS) through down-regulation of ACE2 with subsequent increment of the harmful Ang II serum levels and reduction of the protective Ang-(1-7).	Angiotensin II	218-224	angiotensin converting enzyme 2	Homo sapiens	66-70
34562851-8	2021	The tighter binding interface and the new hydrogen bonds formation also contribute to the improved binding affinity of RBD to the receptor hACE2.	Hydrogen	42-50	angiotensin converting enzyme 2	Homo sapiens	139-144
34516024-6	2021	Using molecular dynamics (MD) simulations and decomposition of intermolecular contacts between the RBD and ACE2, we identified phenylalanine 486, glutamine 498, threonine 500, and tyrosine 505 as important interface-forming residues across viral variants.	Phenylalanine	127-140	angiotensin converting enzyme 2	Homo sapiens	107-111
34516024-6	2021	Using molecular dynamics (MD) simulations and decomposition of intermolecular contacts between the RBD and ACE2, we identified phenylalanine 486, glutamine 498, threonine 500, and tyrosine 505 as important interface-forming residues across viral variants.	Glutamine	146-155	angiotensin converting enzyme 2	Homo sapiens	107-111
34516024-6	2021	Using molecular dynamics (MD) simulations and decomposition of intermolecular contacts between the RBD and ACE2, we identified phenylalanine 486, glutamine 498, threonine 500, and tyrosine 505 as important interface-forming residues across viral variants.	Threonine	161-170	angiotensin converting enzyme 2	Homo sapiens	107-111
34516024-6	2021	Using molecular dynamics (MD) simulations and decomposition of intermolecular contacts between the RBD and ACE2, we identified phenylalanine 486, glutamine 498, threonine 500, and tyrosine 505 as important interface-forming residues across viral variants.	Tyrosine	180-188	angiotensin converting enzyme 2	Homo sapiens	107-111
34677731-0	2021	Eugenol, a Component of Holy Basil (Tulsi) and Common Spice Clove, Inhibits the Interaction Between SARS-CoV-2 Spike S1 and ACE2 to Induce Therapeutic Responses.	Eugenol	0-7	angiotensin converting enzyme 2	Homo sapiens	124-128
34677731-4	2021	Therefore, we screened different components of Tulsi leaf and found that eugenol, but not other major components (e.g. ursolic acid, oleanolic acid and beta-caryophylline), inhibited the interaction between spike S1 and ACE2 in an AlphaScreen-based assay.	Eugenol	73-80	angiotensin converting enzyme 2	Homo sapiens	220-224
34677731-4	2021	Therefore, we screened different components of Tulsi leaf and found that eugenol, but not other major components (e.g. ursolic acid, oleanolic acid and beta-caryophylline), inhibited the interaction between spike S1 and ACE2 in an AlphaScreen-based assay.	ursolic acid	119-131	angiotensin converting enzyme 2	Homo sapiens	220-224
34529122-9	2021	Soluble ACE2 was higher in patients treated with angiotensin receptors blockers and beta-blockers, accordingly with losartan and metoprolol upregulation of ACE1 and ACE2 in HUVECs.	Losartan	116-124	angiotensin converting enzyme 2	Homo sapiens	8-12
34529122-9	2021	Soluble ACE2 was higher in patients treated with angiotensin receptors blockers and beta-blockers, accordingly with losartan and metoprolol upregulation of ACE1 and ACE2 in HUVECs.	Losartan	116-124	angiotensin converting enzyme 2	Homo sapiens	165-169
34529122-9	2021	Soluble ACE2 was higher in patients treated with angiotensin receptors blockers and beta-blockers, accordingly with losartan and metoprolol upregulation of ACE1 and ACE2 in HUVECs.	Metoprolol	129-139	angiotensin converting enzyme 2	Homo sapiens	8-12
34529122-9	2021	Soluble ACE2 was higher in patients treated with angiotensin receptors blockers and beta-blockers, accordingly with losartan and metoprolol upregulation of ACE1 and ACE2 in HUVECs.	Metoprolol	129-139	angiotensin converting enzyme 2	Homo sapiens	165-169
34677731-4	2021	Therefore, we screened different components of Tulsi leaf and found that eugenol, but not other major components (e.g. ursolic acid, oleanolic acid and beta-caryophylline), inhibited the interaction between spike S1 and ACE2 in an AlphaScreen-based assay.	Oleanolic Acid	133-147	angiotensin converting enzyme 2	Homo sapiens	220-224
34607208-6	2021	Quercetin derivatives (CMP-4, CMP-5, CMP-6 and CMP-7) were found highly stable in the active domain of NRP1, ACE2 and Spike protein.	Quercetin	0-9	angiotensin converting enzyme 2	Homo sapiens	109-113
34677731-4	2021	Therefore, we screened different components of Tulsi leaf and found that eugenol, but not other major components (e.g. ursolic acid, oleanolic acid and beta-caryophylline), inhibited the interaction between spike S1 and ACE2 in an AlphaScreen-based assay.	beta-caryophylline	152-170	angiotensin converting enzyme 2	Homo sapiens	220-224
34677731-6	2021	Accordingly, eugenol strongly suppressed the entry of pseudotyped SARS-CoV-2, but not vesicular stomatitis virus (VSV), into human ACE2-expressing HEK293 cells.	Eugenol	13-20	angiotensin converting enzyme 2	Homo sapiens	131-135
34176080-1	2021	Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin-angiotensin-aldosterone system pathway, and other cardiovascular system disorders.	Aldosterone	118-129	angiotensin converting enzyme 2	Homo sapiens	55-59
34485782-8	2021	Only one residue of RBD involved in the specific interactions with ACE2 during the cell infection is involved in the direct contact of the adsorbed S-protein with the graphene.	Graphite	167-175	angiotensin converting enzyme 2	Homo sapiens	67-71
34664036-7	2021	Maintaining proper blood glucose levels using oral antidiabetic drugs like Metformin reduced the detrimental effects of COVID-19 by different possible mechanisms such as Metformin-mediated anti-inflammatory and immunomodulatory activities; effect on viral entry and ACE2 stability; inhibition of virus infection; alters virus survival and endosomal pH; mTOR inhibition; and influence on gut microbiota.	Metformin	75-84	angiotensin converting enzyme 2	Homo sapiens	266-270
34967175-6	2021	Based on the analysis of 72 articles using the MEDLINE database (PubMed), it can be concluded that testosterone is involved in the co-regulation of the synthesis of angiotensin-converting enzyme-2 and transmembrane serine protease-2, facilitating the penetration of SARS-CoV-2 into target cells and promoting easier infection in men.	Testosterone	99-111	angiotensin converting enzyme 2	Homo sapiens	165-196
34189703-2	2021	Enhancing ACE2 activity using GSK2586881, a recombinant form of human ACE2, could be beneficial in diseases such as ARDS but may blunt the hypoxic pulmonary vasoconstriction (HPV) response and potentially impact systemic and tissue oxygenation.	gsk2586881	30-40	angiotensin converting enzyme 2	Homo sapiens	10-14
34189703-2	2021	Enhancing ACE2 activity using GSK2586881, a recombinant form of human ACE2, could be beneficial in diseases such as ARDS but may blunt the hypoxic pulmonary vasoconstriction (HPV) response and potentially impact systemic and tissue oxygenation.	gsk2586881	30-40	angiotensin converting enzyme 2	Homo sapiens	70-74
34884604-1	2021	Alternative branches of the classical renin-angiotensin-aldosterone system (RAS) represent an important cascade in which angiotensin 2 (AngII) undergoes cleavage via the action of the angiotensin-converting enzyme 2 (ACE2) with subsequent production of Ang(1-7) and other related metabolites eliciting its effects via Mas receptor activation.	Aldosterone	56-67	angiotensin converting enzyme 2	Homo sapiens	184-215
34884756-9	2021	Cannabis is another popular combustible product that shares some similarities with cigarette smoke, however, cannabis contains cannabinoids that may reduce inflammation and/or ACE2 levels.	Cannabinoids	127-139	angiotensin converting enzyme 2	Homo sapiens	176-180
34884604-1	2021	Alternative branches of the classical renin-angiotensin-aldosterone system (RAS) represent an important cascade in which angiotensin 2 (AngII) undergoes cleavage via the action of the angiotensin-converting enzyme 2 (ACE2) with subsequent production of Ang(1-7) and other related metabolites eliciting its effects via Mas receptor activation.	Aldosterone	56-67	angiotensin converting enzyme 2	Homo sapiens	217-221
34815544-7	2021	The dissociation constant of 124I-RBD binding to hACE2 was 75.7 nM.	124i-rbd	29-37	angiotensin converting enzyme 2	Homo sapiens	49-54
34838735-9	2022	KEY RESULTS: SARS-CoV-2 infected HUVECs, which express ACE2 and TMPRSS2 proteins, and promoted mitochondrial dysfunction, i.e. it increased mitochondria-derived superoxide anion, mitochondrial membrane potential, and mtDNA release, leading to activation of TLR9 and NF-kB, and release of cytokines.	Superoxides	161-177	angiotensin converting enzyme 2	Homo sapiens	55-59
34817202-9	2022	Viruses pseudotyped with natural variants of the serine/threonine residues implicated in O-linked glycosylation were generally infectious and exhibited sensitivity to neutralization by soluble ACE2 and convalescent antisera comparable to that of the wild-type virus.	Serine	49-55	angiotensin converting enzyme 2	Homo sapiens	193-197
34817202-9	2022	Viruses pseudotyped with natural variants of the serine/threonine residues implicated in O-linked glycosylation were generally infectious and exhibited sensitivity to neutralization by soluble ACE2 and convalescent antisera comparable to that of the wild-type virus.	Threonine	56-65	angiotensin converting enzyme 2	Homo sapiens	193-197
34899289-6	2021	Glycyrrhizin and glycyrrhetinic acid inhibit the synthesis of inflammatory factors and inflammatory mediators by blocking the binding of ACE 2 to virus spike protein, and exert antiviral and antibacterial effects.	Glycyrrhizic Acid	0-12	angiotensin converting enzyme 2	Homo sapiens	137-142
34899289-6	2021	Glycyrrhizin and glycyrrhetinic acid inhibit the synthesis of inflammatory factors and inflammatory mediators by blocking the binding of ACE 2 to virus spike protein, and exert antiviral and antibacterial effects.	Glycyrrhetinic Acid	17-36	angiotensin converting enzyme 2	Homo sapiens	137-142
34819560-4	2021	The possible scenarios of lysine aminoacid residues on surface transformed by glycation were considered: (1) on ACE2 receptor; (2) on Spike protein; (3) on both ACE2 receptor and Spike protein.	lysine aminoacid	26-42	angiotensin converting enzyme 2	Homo sapiens	112-116
34819560-4	2021	The possible scenarios of lysine aminoacid residues on surface transformed by glycation were considered: (1) on ACE2 receptor; (2) on Spike protein; (3) on both ACE2 receptor and Spike protein.	lysine aminoacid	26-42	angiotensin converting enzyme 2	Homo sapiens	161-165
34813629-9	2021	Ursodeoxycholate was previously reported to inhibit binding of SARS-CoV-2 to angiotensin-converting enzyme 2; suppress pro-inflammatory cytokines like TNF-alpha, IL-1beta, IL-2, IL-4, and IL-6; have antioxidant and anti-apoptotic effects; and increase alveolar fluid clearance in acute respiratory distress syndrome.	Ursodeoxycholic Acid	0-16	angiotensin converting enzyme 2	Homo sapiens	77-108
34867390-2	2021	However, ACE2 also converts angiotensin II into angiotensin-(1-7) and counterbalances the renin-angiotensin-aldosterone system, with resultant protective effects in the cardiovascular system.	Aldosterone	108-119	angiotensin converting enzyme 2	Homo sapiens	9-13
34592572-4	2021	We found that de-glycosylation at N331 and N343 drastically reduces the RBD binding to ACE2.	Amodiaquine	34-38	angiotensin converting enzyme 2	Homo sapiens	87-91
34592572-4	2021	We found that de-glycosylation at N331 and N343 drastically reduces the RBD binding to ACE2.	2-Hydroxy-3-methyl-5-nitropyridine	43-47	angiotensin converting enzyme 2	Homo sapiens	87-91
34869209-16	2021	SARS-CoV-2 spike glycans are associated with host ACE2 receptor interaction efficiency.	Polysaccharides	17-24	angiotensin converting enzyme 2	Homo sapiens	50-54
34867390-4	2021	Aim: Determine whether exposure of bronchial AECs to the ARB losartan or the ACEI captopril modulate expression of ACE2 by AECs, SARS CoV2 replication, or expression of proinflammatory cytokines and type I and III interferon (IFN) responses.	Captopril	82-91	angiotensin converting enzyme 2	Homo sapiens	115-119
34661088-0	2021	The effect of N-glycosylation of SARS-CoV-2 spike protein on the virus interaction with the host cell ACE2 receptor.	Nitrogen	14-15	angiotensin converting enzyme 2	Homo sapiens	102-106
34867400-5	2021	Interestingly, ACE2 levels were highly correlated with ISGs-induced NF-kappaB activities, but not IFNbeta levels.	isgs	55-59	angiotensin converting enzyme 2	Homo sapiens	15-19
34867400-6	2021	Furthermore, using an approved clinical durgs library, we found two clinical drugs, Cepharanthine and Glucosamine, significantly inhibited ACE2 level, IFNbeta level, and NF-kappaB signaling downstream TNFalpha and IL6 levels.	cepharanthine	84-97	angiotensin converting enzyme 2	Homo sapiens	139-143
34867400-6	2021	Furthermore, using an approved clinical durgs library, we found two clinical drugs, Cepharanthine and Glucosamine, significantly inhibited ACE2 level, IFNbeta level, and NF-kappaB signaling downstream TNFalpha and IL6 levels.	Glucosamine	102-113	angiotensin converting enzyme 2	Homo sapiens	139-143
34661088-5	2021	Molecular dynamic simulations of the S1 protein-ACE2 receptor complex revealed the steric hinderance and Coulombic repulsion effects of different types of N-glycans on the S1 protein interaction with ACE2.	n-glycans	155-164	angiotensin converting enzyme 2	Homo sapiens	48-52
34661088-5	2021	Molecular dynamic simulations of the S1 protein-ACE2 receptor complex revealed the steric hinderance and Coulombic repulsion effects of different types of N-glycans on the S1 protein interaction with ACE2.	n-glycans	155-164	angiotensin converting enzyme 2	Homo sapiens	200-204
34543092-3	2021	Here we screened 512 pure compounds derived from natural products using a high-throughput RBD/ACE2 binding assay and identified (-)-hopeaphenol, a resveratrol tetramer, in addition to vatalbinoside A and vaticanol B, as potent and selective inhibitors of RBD/ACE2 binding and viral entry.	hopeaphenol	132-143	angiotensin converting enzyme 2	Homo sapiens	259-263
34797899-3	2021	Expression of members of the TIM (TIM-1 and TIM-4) and TAM (AXL) families of PS receptors enhance SARS-CoV-2 binding to cells, facilitate internalization of fluorescently-labeled virions and increase ACE2-dependent infection of SARS-CoV-2; however, PS receptors alone did not mediate infection.	Tamoxifen	55-58	angiotensin converting enzyme 2	Homo sapiens	200-204
34543092-4	2021	For example, (-)-hopeaphenol disrupted RBD/ACE2 binding with a 50% inhibitory concentration (IC50) of 0.11 muM in contrast to an IC50 of 28.3 muM against the unrelated host ligand/receptor binding pair PD-1/PD-L1 (selectivity index = 257.3).	hopeaphenol	17-28	angiotensin converting enzyme 2	Homo sapiens	43-47
34835087-6	2021	Here, we identified the human PDZ specificity profile of the ACE2 PBM using the high-throughput holdup assay and measuring the binding intensities of the PBM of ACE2 against the full human PDZome.	pbm	154-157	angiotensin converting enzyme 2	Homo sapiens	161-165
34869917-1	2021	Aims: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the ACE2 component of the renin-angiotensin aldosterone system (RAAS) and infects the human cells.	Aldosterone	124-135	angiotensin converting enzyme 2	Homo sapiens	84-88
34783057-7	2022	Surprisingly, we discovered that this mutation reduces the immunogenicity of the spike protein; also, displacement of Asn with Tyr reduces protein compactness and significantly increases the stability of the spike protein and its affinity to ACE2.	Asparagine	118-121	angiotensin converting enzyme 2	Homo sapiens	242-246
34783057-7	2022	Surprisingly, we discovered that this mutation reduces the immunogenicity of the spike protein; also, displacement of Asn with Tyr reduces protein compactness and significantly increases the stability of the spike protein and its affinity to ACE2.	Tyrosine	127-130	angiotensin converting enzyme 2	Homo sapiens	242-246
34835087-9	2021	The PDZ/PBM interactions with ACE2 could play a role in ACE2 internalization and recycling that could be of benefit for the virus entry.	6-(4-chloro-2-fluoro-3-phenoxybenzyl)pyridazin-3(2H)-one	4-7	angiotensin converting enzyme 2	Homo sapiens	30-34
34835087-9	2021	The PDZ/PBM interactions with ACE2 could play a role in ACE2 internalization and recycling that could be of benefit for the virus entry.	6-(4-chloro-2-fluoro-3-phenoxybenzyl)pyridazin-3(2H)-one	4-7	angiotensin converting enzyme 2	Homo sapiens	56-60
34835087-9	2021	The PDZ/PBM interactions with ACE2 could play a role in ACE2 internalization and recycling that could be of benefit for the virus entry.	pbm	8-11	angiotensin converting enzyme 2	Homo sapiens	30-34
34835087-9	2021	The PDZ/PBM interactions with ACE2 could play a role in ACE2 internalization and recycling that could be of benefit for the virus entry.	pbm	8-11	angiotensin converting enzyme 2	Homo sapiens	56-60
34658235-6	2021	Mechanistically, we demonstrate that the atovaquone antiviral activity against SARS-CoV-2 is partially dependent on the expression of TMPRSS2 and that the drug can disrupt the interaction of the spike protein with the viral receptor, ACE2.	Atovaquone	41-51	angiotensin converting enzyme 2	Homo sapiens	234-238
34790977-4	2021	The structure of NIH-CoVnb-112 bound to SARS-CoV-2 RBD reveals a large contact surface area overlapping the angiotensin converting enzyme 2 (ACE2) binding site, which is largely unencumbered by the common RBD mutations.	nih-covnb-112	17-30	angiotensin converting enzyme 2	Homo sapiens	108-139
34790977-4	2021	The structure of NIH-CoVnb-112 bound to SARS-CoV-2 RBD reveals a large contact surface area overlapping the angiotensin converting enzyme 2 (ACE2) binding site, which is largely unencumbered by the common RBD mutations.	nih-covnb-112	17-30	angiotensin converting enzyme 2	Homo sapiens	141-145
34749700-13	2021	Further, FA-treated mammalian cells showed significant overexpression of ACE-2, NRP-1 and TMPRSS2 genes except with L-lactic acid and oleic acid caused downregulation of NRP-1 gene, while 17-octadecynoic acid caused insignificant effect.	Lactic Acid	116-129	angiotensin converting enzyme 2	Homo sapiens	73-78
34773067-4	2021	Here we report that ouabain, digitoxin, and digoxin, as well as sugar-free derivatives digitoxigenin and digoxigenin, are high-affinity competitive inhibitors of ACE2 binding to the Original (D614) S1 and the alpha/beta/gamma (D614G) S1 proteins.	Ouabain	20-27	angiotensin converting enzyme 2	Homo sapiens	162-166
34773067-4	2021	Here we report that ouabain, digitoxin, and digoxin, as well as sugar-free derivatives digitoxigenin and digoxigenin, are high-affinity competitive inhibitors of ACE2 binding to the Original (D614) S1 and the alpha/beta/gamma (D614G) S1 proteins.	Digitoxin	29-38	angiotensin converting enzyme 2	Homo sapiens	162-166
34773067-4	2021	Here we report that ouabain, digitoxin, and digoxin, as well as sugar-free derivatives digitoxigenin and digoxigenin, are high-affinity competitive inhibitors of ACE2 binding to the Original (D614) S1 and the alpha/beta/gamma (D614G) S1 proteins.	Digoxin	44-51	angiotensin converting enzyme 2	Homo sapiens	162-166
34773067-4	2021	Here we report that ouabain, digitoxin, and digoxin, as well as sugar-free derivatives digitoxigenin and digoxigenin, are high-affinity competitive inhibitors of ACE2 binding to the Original (D614) S1 and the alpha/beta/gamma (D614G) S1 proteins.	Digitoxigenin	87-100	angiotensin converting enzyme 2	Homo sapiens	162-166
34773067-4	2021	Here we report that ouabain, digitoxin, and digoxin, as well as sugar-free derivatives digitoxigenin and digoxigenin, are high-affinity competitive inhibitors of ACE2 binding to the Original (D614) S1 and the alpha/beta/gamma (D614G) S1 proteins.	Digoxigenin	105-116	angiotensin converting enzyme 2	Homo sapiens	162-166
34784554-9	2021	Vitamin D increased ACE2 expression and Ang-1-7 plasma levels and also decreased Ang II level in plasma.	Vitamin D	0-9	angiotensin converting enzyme 2	Homo sapiens	20-24
34749700-13	2021	Further, FA-treated mammalian cells showed significant overexpression of ACE-2, NRP-1 and TMPRSS2 genes except with L-lactic acid and oleic acid caused downregulation of NRP-1 gene, while 17-octadecynoic acid caused insignificant effect.	Oleic Acid	134-144	angiotensin converting enzyme 2	Homo sapiens	73-78
34558135-2	2021	The interaction between the SARS-CoV-2 spike protein and the human receptor angiotensin-converting enzyme 2, both of which contain several cysteine residues, is impacted by the disulfide-thiol balance in the host cell.	Cysteine	139-147	angiotensin converting enzyme 2	Homo sapiens	76-107
34474305-0	2021	Synthesis of novel calcium channel blockers with ACE2 inhibition and dual antihypertensive/anti-inflammatory effects: A possible therapeutic tool for COVID-19.	Calcium	19-26	angiotensin converting enzyme 2	Homo sapiens	49-53
34474305-3	2021	In this study, we report synthesis of some bioisosteres of pyrimidines as novel CCBs with potential ACE2 inhibitory effect as antihypertensive agents with protective effect against COVID-19 infection by suppression of ACE2 binding to SARS-CoV-2 Spike RBD.	Pyrimidines	59-70	angiotensin converting enzyme 2	Homo sapiens	100-104
34474305-3	2021	In this study, we report synthesis of some bioisosteres of pyrimidines as novel CCBs with potential ACE2 inhibitory effect as antihypertensive agents with protective effect against COVID-19 infection by suppression of ACE2 binding to SARS-CoV-2 Spike RBD.	Pyrimidines	59-70	angiotensin converting enzyme 2	Homo sapiens	218-222
34655895-6	2021	Additional salt bridges, hydrogen bonds, and a high number of non-bonded contacts (i.e., non-bonded interactions between atoms in the same molecule and those in other molecules) were observed only in the mutant complexes, allowing efficient binding to the ACE2 receptor.	Hydrogen	25-33	angiotensin converting enzyme 2	Homo sapiens	256-260
34746476-11	2021	Echoside A and echoside B showed higher docking score than remdesivir as COVID-19 drug on four target proteins, i.e., spike protein (-7.9 kcal/mol and -7.8 kcal/mol), RBD-ACE2 (-7.5 kcal/mol and -8.2 kcal/mol), 3CLpro (-8.4 kcal/mol and -9.4 kcal/mol) and RdRp (-7.3 kcal/mol and -8.0 kcal/mol).	remdesivir	59-69	angiotensin converting enzyme 2	Homo sapiens	171-175
34741481-0	2022	Understanding the binding mechanism for potential inhibition of SARS-CoV-2 Mpro and exploring the modes of ACE2 inhibition by hydroxychloroquine.	Hydroxychloroquine	126-144	angiotensin converting enzyme 2	Homo sapiens	107-111
34732115-5	2022	ACE2 metabolizes angiotensin II and several peptides, including apelin-13, neurotensin, kinetensin, dynorphin, (des-Arg9) bradykinin, and (Lys-des-Arg9)-bradykinin, which may elicit neuroprotective effects.	Peptides	44-52	angiotensin converting enzyme 2	Homo sapiens	0-4
34732115-5	2022	ACE2 metabolizes angiotensin II and several peptides, including apelin-13, neurotensin, kinetensin, dynorphin, (des-Arg9) bradykinin, and (Lys-des-Arg9)-bradykinin, which may elicit neuroprotective effects.	kinetensin	88-98	angiotensin converting enzyme 2	Homo sapiens	0-4
34507112-7	2021	Glycyrrhizin in vitro connects and changes conformation of ACE2 receptors, which are vital for SARS-CoV-2 penetration into host cells.	Glycyrrhizic Acid	0-12	angiotensin converting enzyme 2	Homo sapiens	59-63
34547822-3	2021	Spike protein-expressing cells bound to hACE2 in the absence or presence of blocking antibodies were quantified by measuring the optical density of cell-associated crystal violet in a spectrophotometer.	Gentian Violet	164-178	angiotensin converting enzyme 2	Homo sapiens	40-45
33637588-0	2021	Cyclic gallium-68 labeled peptides for specific detection of human angiotensin-converting enzyme 2.	cyclic gallium	0-14	angiotensin converting enzyme 2	Homo sapiens	67-98
33637588-0	2021	Cyclic gallium-68 labeled peptides for specific detection of human angiotensin-converting enzyme 2.	Peptides	26-34	angiotensin converting enzyme 2	Homo sapiens	67-98
33637588-2	2021	Methods: A series of NOTA-conjugated peptides derived from the known ACE2 inhibitor DX600 were synthesized, with variable linker identity.	dx600	84-89	angiotensin converting enzyme 2	Homo sapiens	69-73
34619249-6	2021	In non-PCOS controls, plasma ACE2 decreased from vitamin D insufficiency to deficiency (p < 0.05).	Vitamin D	49-58	angiotensin converting enzyme 2	Homo sapiens	29-33
34619249-9	2021	In addition, decreased plasma ACE2 levels were seen in vitamin D deficiency in non-PCOS controls, which may predispose these vitamin D deficient subjects to increased cardiovascular risk and susceptibility to infectious agents such as COVID-19 where this is a risk factor.	Vitamin D	55-64	angiotensin converting enzyme 2	Homo sapiens	30-34
34619249-9	2021	In addition, decreased plasma ACE2 levels were seen in vitamin D deficiency in non-PCOS controls, which may predispose these vitamin D deficient subjects to increased cardiovascular risk and susceptibility to infectious agents such as COVID-19 where this is a risk factor.	Vitamin D	125-134	angiotensin converting enzyme 2	Homo sapiens	30-34
34558135-2	2021	The interaction between the SARS-CoV-2 spike protein and the human receptor angiotensin-converting enzyme 2, both of which contain several cysteine residues, is impacted by the disulfide-thiol balance in the host cell.	Disulfides	177-186	angiotensin converting enzyme 2	Homo sapiens	76-107
34558135-2	2021	The interaction between the SARS-CoV-2 spike protein and the human receptor angiotensin-converting enzyme 2, both of which contain several cysteine residues, is impacted by the disulfide-thiol balance in the host cell.	Sulfhydryl Compounds	187-192	angiotensin converting enzyme 2	Homo sapiens	76-107
34494876-16	2021	These findings offer insight into the glycan structure and function of ACE2 and potentially suggest that future antiviral therapies against coronaviruses and other coronavirus-related illnesses involving inhibition of ACE2 recruitment to the cell membrane could be developed.	Polysaccharides	38-44	angiotensin converting enzyme 2	Homo sapiens	71-75
34647745-1	2021	Cellular binding and entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are mediated by its spike glycoprotein (S protein), which binds with not only the human angiotensin-converting enzyme 2 (ACE2) receptor but also glycosaminoglycans such as heparin.	Glycosaminoglycans	236-254	angiotensin converting enzyme 2	Homo sapiens	179-210
34494876-0	2021	Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2.	Nitrogen	24-25	angiotensin converting enzyme 2	Homo sapiens	131-135
34494876-3	2021	Previous work has demonstrated the presence of N-linked glycans in ACE2.	n-linked glycans	47-63	angiotensin converting enzyme 2	Homo sapiens	67-71
34494876-5	2021	However, the contribution of N-glycosylation to ACE2 function is poorly understood.	Nitrogen	29-30	angiotensin converting enzyme 2	Homo sapiens	48-52
34494876-7	2021	The elimination of N-glycosylation by tunicamycin (TM) treatment, or mutagenesis, showed that N-glycosylation is critical for the proper cell surface expression of ACE2 but not for its carboxiprotease activity.	Nitrogen	19-20	angiotensin converting enzyme 2	Homo sapiens	164-168
34494876-7	2021	The elimination of N-glycosylation by tunicamycin (TM) treatment, or mutagenesis, showed that N-glycosylation is critical for the proper cell surface expression of ACE2 but not for its carboxiprotease activity.	Tunicamycin	38-49	angiotensin converting enzyme 2	Homo sapiens	164-168
34494876-7	2021	The elimination of N-glycosylation by tunicamycin (TM) treatment, or mutagenesis, showed that N-glycosylation is critical for the proper cell surface expression of ACE2 but not for its carboxiprotease activity.	Tunicamycin	51-53	angiotensin converting enzyme 2	Homo sapiens	164-168
34494876-7	2021	The elimination of N-glycosylation by tunicamycin (TM) treatment, or mutagenesis, showed that N-glycosylation is critical for the proper cell surface expression of ACE2 but not for its carboxiprotease activity.	Nitrogen	94-95	angiotensin converting enzyme 2	Homo sapiens	164-168
34494876-10	2021	Impairment of hACE2 N-glycosylation decreased cell-to-cell fusion mediated by SARS-CoV S protein but not that mediated by SARS-CoV-2 S protein.	Nitrogen	20-21	angiotensin converting enzyme 2	Homo sapiens	14-19
34494876-11	2021	Finally, we found that hACE2 N-glycosylation is required for an efficient viral entry of SARS-CoV/SARS-CoV-2 S pseudotyped viruses, which may be the result of low cell surface expression of the deglycosylated ACE2 receptor.	Nitrogen	29-30	angiotensin converting enzyme 2	Homo sapiens	23-28
34494876-14	2021	In addition, we found that the removal of N-glycans of ACE2 impaired its ability to support an efficient transduction of SARS-CoV and SARS-CoV-2 S pseudotyped viruses.	n-glycans	42-51	angiotensin converting enzyme 2	Homo sapiens	55-59
34753008-3	2021	Melatonin is synthesized from tryptophan via the serotonin pathway and melatonin deficiency in COVID-19 arises from the faulty absorption of tryptophan from the food because SARS-CoV-2 downregulates angiotensin-converting enzyme-2, the chaperone of the transporter of tryptophan.	Tryptophan	141-151	angiotensin converting enzyme 2	Homo sapiens	199-230
34753008-3	2021	Melatonin is synthesized from tryptophan via the serotonin pathway and melatonin deficiency in COVID-19 arises from the faulty absorption of tryptophan from the food because SARS-CoV-2 downregulates angiotensin-converting enzyme-2, the chaperone of the transporter of tryptophan.	Tryptophan	268-278	angiotensin converting enzyme 2	Homo sapiens	199-230
34642088-5	2021	Furthermore, ISA 720-adjuvanted AKS-452 was immunogenic in rabbits and non-human primates (NHPs) and protected from infection and clinical symptoms with live SARS-CoV-2 virus in NHPs (USA-WA1/2020 viral strain) and the K18 human ACE2-trangenic (K18-huACE2-Tg) mouse (South African B.1.351 viral variant).	mannide monooleate	13-20	angiotensin converting enzyme 2	Homo sapiens	229-233
34647745-1	2021	Cellular binding and entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are mediated by its spike glycoprotein (S protein), which binds with not only the human angiotensin-converting enzyme 2 (ACE2) receptor but also glycosaminoglycans such as heparin.	Glycosaminoglycans	236-254	angiotensin converting enzyme 2	Homo sapiens	212-216
34647745-1	2021	Cellular binding and entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are mediated by its spike glycoprotein (S protein), which binds with not only the human angiotensin-converting enzyme 2 (ACE2) receptor but also glycosaminoglycans such as heparin.	Heparin	263-270	angiotensin converting enzyme 2	Homo sapiens	179-210
34647745-1	2021	Cellular binding and entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are mediated by its spike glycoprotein (S protein), which binds with not only the human angiotensin-converting enzyme 2 (ACE2) receptor but also glycosaminoglycans such as heparin.	Heparin	263-270	angiotensin converting enzyme 2	Homo sapiens	212-216
34652144-8	2021	The identified ligand was employed for the synthesis of multivalent glycopolymers that were able to inhibit SARS-CoV-2 spike glycoprotein binding to DC-SIGN-expressing cells, as well as DC-SIGN-mediated trans-infection of ACE2+ cells by SARS-CoV-2 spike protein-expressing viruses, in nanomolar concentrations.	glycopolymers	68-81	angiotensin converting enzyme 2	Homo sapiens	222-226
34759823-9	2021	In addition, those representative constituents with good affinity on Topo I, Topo II, COX-2, or ACE2, such as diphyllin, podophyllotoxin, and diphyllin O-glucoside, were further validated with molecular docking analysis.	diphyllin	110-119	angiotensin converting enzyme 2	Homo sapiens	96-100
34829773-7	2021	OM-85 significantly reduced the expression of ACE2 (p < 0.001), TMPRSS2 (p < 0.001), DPP4 (p < 0.005), and cellular heparan sulfate (p < 0.01), while ADAM17 (p < 0.02) expression was significantly upregulated.	om-85	0-5	angiotensin converting enzyme 2	Homo sapiens	46-50
34759823-9	2021	In addition, those representative constituents with good affinity on Topo I, Topo II, COX-2, or ACE2, such as diphyllin, podophyllotoxin, and diphyllin O-glucoside, were further validated with molecular docking analysis.	Podophyllotoxin	121-136	angiotensin converting enzyme 2	Homo sapiens	96-100
34759823-9	2021	In addition, those representative constituents with good affinity on Topo I, Topo II, COX-2, or ACE2, such as diphyllin, podophyllotoxin, and diphyllin O-glucoside, were further validated with molecular docking analysis.	Cleistanthin B	142-163	angiotensin converting enzyme 2	Homo sapiens	96-100
34581563-5	2021	H11-H4, and to a lesser extent H11-D4, binding dislocates ACE2 from its binding site due to electrostatic repulsion.	h11-h4	0-6	angiotensin converting enzyme 2	Homo sapiens	58-62
34677831-0	2021	d-Galactose treatment increases ACE2, TMPRSS2, and FURIN and reduces SERPINA1 mRNA expression in A549 human lung epithelial cells.	Galactose	0-11	angiotensin converting enzyme 2	Homo sapiens	32-36
34581563-5	2021	H11-H4, and to a lesser extent H11-D4, binding dislocates ACE2 from its binding site due to electrostatic repulsion.	h11-d4	31-37	angiotensin converting enzyme 2	Homo sapiens	58-62
34581563-7	2021	Mutations in the Alpha variant of SARS-CoV-2 had a minor effect in RBD binding strengths of ACE2 and nanobodies, but reduced the ability of H11-H4 and H11-D4 to dislocate ACE2 from RBD.	h11	140-143	angiotensin converting enzyme 2	Homo sapiens	171-175
34581563-7	2021	Mutations in the Alpha variant of SARS-CoV-2 had a minor effect in RBD binding strengths of ACE2 and nanobodies, but reduced the ability of H11-H4 and H11-D4 to dislocate ACE2 from RBD.	h11	151-154	angiotensin converting enzyme 2	Homo sapiens	171-175
34581563-8	2021	In comparison, the Beta variant weakened the RBD binding strengths of H11-H4 and H11-D4, which were less effective to dislocate ACE2 binding.	h11	70-73	angiotensin converting enzyme 2	Homo sapiens	128-132
34581563-8	2021	In comparison, the Beta variant weakened the RBD binding strengths of H11-H4 and H11-D4, which were less effective to dislocate ACE2 binding.	h11-d4	81-87	angiotensin converting enzyme 2	Homo sapiens	128-132
34680595-4	2021	A reduced ACE2/RBD binding inhibition activity of spike-specific antibodies was also observed, especially in ruxolitinib-treated patients.	ruxolitinib	109-120	angiotensin converting enzyme 2	Homo sapiens	10-14
34545347-4	2021	We demonstrate that silencing the circadian regulator Bmal1 or treating lung epithelial cells with the REV-ERB agonist SR9009 reduce ACE2 expression and inhibit SARS-CoV-2 entry and replication.	SR9009	119-125	angiotensin converting enzyme 2	Homo sapiens	133-137
34673795-2	2021	As the SARS-CoV2 virus enters cells via the angiotensin-converting enzyme receptor II (ACE2), drugs which interact with the renin angiotensin aldosterone system (RAAS) were suspected to influence disease severity.	Aldosterone	142-153	angiotensin converting enzyme 2	Homo sapiens	87-91
34678509-5	2022	Our integrated in silico and in vitro results confirmed the dual potential effect of the Montelukast both on the main protease enzyme inhibition and virus entry into the host cell (Spike/ACE2).	montelukast	89-100	angiotensin converting enzyme 2	Homo sapiens	187-191
34690521-3	2022	Through molecular docking and dynamic simulation studies, we used the FDA-approved drug mezonavir against the most important viral targets, including spike (S) glycoprotein, Transmembrane serine protease 2 (TMPRSS2), RNA-dependent RNA polymerase (RdRp), Main protease (Mpro), human angiotensin-converting enzyme 2 (ACE-2), and furin.	mezonavir	88-97	angiotensin converting enzyme 2	Homo sapiens	282-313
34690521-3	2022	Through molecular docking and dynamic simulation studies, we used the FDA-approved drug mezonavir against the most important viral targets, including spike (S) glycoprotein, Transmembrane serine protease 2 (TMPRSS2), RNA-dependent RNA polymerase (RdRp), Main protease (Mpro), human angiotensin-converting enzyme 2 (ACE-2), and furin.	mezonavir	88-97	angiotensin converting enzyme 2	Homo sapiens	315-320
34677831-8	2021	Here we show that treatment of A549 human lung epithelial cells for 7 days with 25 mM d-galactose, an inducer of diabetic-like and oxidative stress cellular phenotypes, leads to increased mRNA levels of ACE2, TMPRSS2, and FURIN, along with reduced SERPINA1 mRNA.	Galactose	86-97	angiotensin converting enzyme 2	Homo sapiens	203-207
34672164-6	2022	The consumption of alcohol reduces both innate and acquired immune activity and it has been hypothesized that this habit is correlated with liver increase of ACE2 receptors.	Alcohols	19-26	angiotensin converting enzyme 2	Homo sapiens	158-162
34379531-8	2021	L452 is in immediate proximity to the ACE2 interaction interface of RBD.	3,5-dimethoxycinnamic acid	0-4	angiotensin converting enzyme 2	Homo sapiens	38-42
34265150-3	2021	The results predict that NPs of commensal microbiota such as bile acids and non-ribosomal peptides (NRPs), of which some are siderophores, bind to the wild-type RBD and interfere with its binding to the ACE2 receptor.	Bile Acids and Salts	60-70	angiotensin converting enzyme 2	Homo sapiens	202-206
34712133-0	2021	Diminazen Aceturate Protects Pulmonary Ischemia-Reperfusion Injury via Inhibition of ADAM17-Mediated Angiotensin-Converting Enzyme 2 Shedding.	diminazene aceturate	0-19	angiotensin converting enzyme 2	Homo sapiens	101-132
34508662-3	2021	X-ray crystallography revealed coordinated recognition by the heavy chain of non-RBS conserved sites and the light chain of RBS with a binding angle mimicking the angiotensin-converting enzyme 2 (ACE2) receptor.	Roussin's Black Salt	81-84	angiotensin converting enzyme 2	Homo sapiens	196-200
34508662-3	2021	X-ray crystallography revealed coordinated recognition by the heavy chain of non-RBS conserved sites and the light chain of RBS with a binding angle mimicking the angiotensin-converting enzyme 2 (ACE2) receptor.	Roussin's Black Salt	124-127	angiotensin converting enzyme 2	Homo sapiens	163-194
34508662-3	2021	X-ray crystallography revealed coordinated recognition by the heavy chain of non-RBS conserved sites and the light chain of RBS with a binding angle mimicking the angiotensin-converting enzyme 2 (ACE2) receptor.	Roussin's Black Salt	124-127	angiotensin converting enzyme 2	Homo sapiens	196-200
34712133-8	2021	Treatment with ACE2 protectant diminazen aceturate (DIZE) maintained higher ACE2 enzyme activity and reduced angiotensin II, angiotensin type 1 receptor, and ADAM17 levels in the lung tissue.	diminazene aceturate	31-50	angiotensin converting enzyme 2	Homo sapiens	15-19
34712133-8	2021	Treatment with ACE2 protectant diminazen aceturate (DIZE) maintained higher ACE2 enzyme activity and reduced angiotensin II, angiotensin type 1 receptor, and ADAM17 levels in the lung tissue.	diminazene aceturate	31-50	angiotensin converting enzyme 2	Homo sapiens	76-80
34712133-8	2021	Treatment with ACE2 protectant diminazen aceturate (DIZE) maintained higher ACE2 enzyme activity and reduced angiotensin II, angiotensin type 1 receptor, and ADAM17 levels in the lung tissue.	diminazene aceturate	52-56	angiotensin converting enzyme 2	Homo sapiens	15-19
34712133-8	2021	Treatment with ACE2 protectant diminazen aceturate (DIZE) maintained higher ACE2 enzyme activity and reduced angiotensin II, angiotensin type 1 receptor, and ADAM17 levels in the lung tissue.	diminazene aceturate	52-56	angiotensin converting enzyme 2	Homo sapiens	76-80
34638139-0	2021	Activity of THC, CBD, and CBN on Human ACE2 and SARS-CoV1/2 Main Protease to Understand Antiviral Defense Mechanism.	Dronabinol	12-15	angiotensin converting enzyme 2	Homo sapiens	39-43
34712133-11	2021	We concluded that DIZE protects the lungs from IR injury via inhibition of ADAM17-mediated ACE2 shedding.	diminazene aceturate	18-22	angiotensin converting enzyme 2	Homo sapiens	91-95
34638139-2	2021	This study aims to determine the mechanism of action of THC, CBD, and CBN by selecting two essential targets that directly affect the coronavirus infections as viral main proteases and human angiotensin-converting enzyme2.	Dronabinol	56-59	angiotensin converting enzyme 2	Homo sapiens	191-221
34684671-7	2021	Autodocking analysis revealed that the S protein has several GA-binding pockets including one at the interaction interface to the receptor angiotensin-converting enzyme 2 (ACE2) and another at the inner side of the receptor-binding domain (RBD) which might impact the close-to-open conformation change of the S protein required for ACE2 interaction.	Glycyrrhizic Acid	61-63	angiotensin converting enzyme 2	Homo sapiens	139-170
34635175-6	2021	RESULTS: We used diverse cell lines (HK-2, Huh-7, HUVEC, Caco-2, and BEAS-2B) to analyze the effect of VPA and other HDAC inhibitors on the expression of the ACE-2 and NRP-1 receptors and their ability to inhibit infectivity, viral production, and the inflammatory response.	Valproic Acid	103-106	angiotensin converting enzyme 2	Homo sapiens	158-163
34635175-7	2021	Treatment with VPA significantly reduced expression of the ACE2 and NRP1 host proteins in all cell lines through a mechanism mediated by its HDAC inhibitory activity.	Valproic Acid	15-18	angiotensin converting enzyme 2	Homo sapiens	59-63
34684671-7	2021	Autodocking analysis revealed that the S protein has several GA-binding pockets including one at the interaction interface to the receptor angiotensin-converting enzyme 2 (ACE2) and another at the inner side of the receptor-binding domain (RBD) which might impact the close-to-open conformation change of the S protein required for ACE2 interaction.	Glycyrrhizic Acid	61-63	angiotensin converting enzyme 2	Homo sapiens	172-176
34684671-7	2021	Autodocking analysis revealed that the S protein has several GA-binding pockets including one at the interaction interface to the receptor angiotensin-converting enzyme 2 (ACE2) and another at the inner side of the receptor-binding domain (RBD) which might impact the close-to-open conformation change of the S protein required for ACE2 interaction.	Glycyrrhizic Acid	61-63	angiotensin converting enzyme 2	Homo sapiens	332-336
34570497-0	2021	Curious Binding Energy Increase between the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein and Angiotensin-Converting Enzyme 2 Adsorbed on a Silane Monolayer from Molecular Dynamics Simulations.	Silanes	150-156	angiotensin converting enzyme 2	Homo sapiens	104-135
34570497-7	2021	Indeed, silane monolayers, combining silane molecules with short alkyl chains and positively charged head groups and silane molecules without charged head groups, could adsorb the ACE2 while maintaining its bioactivity (orientation compatible with the spike protein trapping, low conformational changes) and increasing its interactions with the spike protein receptor-binding domain (number of hydrogen bonds and electrostatic interactions) to lead to an increase by 20% both in the binding free energy and in the enzyme /receptor-binding domain rupture force.	Silanes	37-43	angiotensin converting enzyme 2	Homo sapiens	180-184
34631362-7	2021	Captopril, moexipril, benazepril, fosinopril, losartan, remdesivir, Sigma ACEI, NAA, and NAM interacted and docked at the interface of ACE2 and SARS-CoV-2 spike protein complex.	Captopril	0-9	angiotensin converting enzyme 2	Homo sapiens	135-139
34570497-7	2021	Indeed, silane monolayers, combining silane molecules with short alkyl chains and positively charged head groups and silane molecules without charged head groups, could adsorb the ACE2 while maintaining its bioactivity (orientation compatible with the spike protein trapping, low conformational changes) and increasing its interactions with the spike protein receptor-binding domain (number of hydrogen bonds and electrostatic interactions) to lead to an increase by 20% both in the binding free energy and in the enzyme /receptor-binding domain rupture force.	Silanes	117-123	angiotensin converting enzyme 2	Homo sapiens	180-184
34696413-0	2021	Xeno-Nucleic Acid (XNA) 2"-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding.	xeno-nucleic acid (xna) 2"-fluoro-arabino nucleic acid	0-54	angiotensin converting enzyme 2	Homo sapiens	132-136
34631362-7	2021	Captopril, moexipril, benazepril, fosinopril, losartan, remdesivir, Sigma ACEI, NAA, and NAM interacted and docked at the interface of ACE2 and SARS-CoV-2 spike protein complex.	moexipril	11-20	angiotensin converting enzyme 2	Homo sapiens	135-139
34631362-7	2021	Captopril, moexipril, benazepril, fosinopril, losartan, remdesivir, Sigma ACEI, NAA, and NAM interacted and docked at the interface of ACE2 and SARS-CoV-2 spike protein complex.	benazepril	22-32	angiotensin converting enzyme 2	Homo sapiens	135-139
34631362-7	2021	Captopril, moexipril, benazepril, fosinopril, losartan, remdesivir, Sigma ACEI, NAA, and NAM interacted and docked at the interface of ACE2 and SARS-CoV-2 spike protein complex.	Fosinopril	34-44	angiotensin converting enzyme 2	Homo sapiens	135-139
34631362-7	2021	Captopril, moexipril, benazepril, fosinopril, losartan, remdesivir, Sigma ACEI, NAA, and NAM interacted and docked at the interface of ACE2 and SARS-CoV-2 spike protein complex.	Losartan	46-54	angiotensin converting enzyme 2	Homo sapiens	135-139
34631362-7	2021	Captopril, moexipril, benazepril, fosinopril, losartan, remdesivir, Sigma ACEI, NAA, and NAM interacted and docked at the interface of ACE2 and SARS-CoV-2 spike protein complex.	remdesivir	56-66	angiotensin converting enzyme 2	Homo sapiens	135-139
34631362-7	2021	Captopril, moexipril, benazepril, fosinopril, losartan, remdesivir, Sigma ACEI, NAA, and NAM interacted and docked at the interface of ACE2 and SARS-CoV-2 spike protein complex.	1-naphthaleneacetic acid	80-83	angiotensin converting enzyme 2	Homo sapiens	135-139
34102269-11	2021	Three active compounds, 4,6-dihydroxyquinoline-2-carboxylic acid, 4-hydroxyquinoline-2-carboxylic acid and 4-hydroxy-6-methoxyquinoline-2-carboxylic acid were identified to inhibit ACE2-RBD interaction (IC50 = 0.58 muM, 0.07 muM and 0.15 muM respectively).	4,6-dihydroxyquinoline-2-carboxylic acid	24-64	angiotensin converting enzyme 2	Homo sapiens	181-185
34102269-11	2021	Three active compounds, 4,6-dihydroxyquinoline-2-carboxylic acid, 4-hydroxyquinoline-2-carboxylic acid and 4-hydroxy-6-methoxyquinoline-2-carboxylic acid were identified to inhibit ACE2-RBD interaction (IC50 = 0.58 muM, 0.07 muM and 0.15 muM respectively).	Kynurenic Acid	66-102	angiotensin converting enzyme 2	Homo sapiens	181-185
34102269-11	2021	Three active compounds, 4,6-dihydroxyquinoline-2-carboxylic acid, 4-hydroxyquinoline-2-carboxylic acid and 4-hydroxy-6-methoxyquinoline-2-carboxylic acid were identified to inhibit ACE2-RBD interaction (IC50 = 0.58 muM, 0.07 muM and 0.15 muM respectively).	4-Hydroxy-6-methoxyquinoline-2-carboxylic acid	107-153	angiotensin converting enzyme 2	Homo sapiens	181-185
34605344-10	2021	CONCLUSION: According to the above results, it is suggested that SQW may play a role in the treatment of COVID-19 by directly or indirectly combining kaempferol, quercetin, and luteolin with ACE2, 3CLpro, PLpro, and PTGS2 to regulate multiple biological functions and signaling pathways.	Luteolin	177-185	angiotensin converting enzyme 2	Homo sapiens	191-195
34696413-0	2021	Xeno-Nucleic Acid (XNA) 2"-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding.	fana	56-60	angiotensin converting enzyme 2	Homo sapiens	132-136
34375000-6	2021	3D modelling showed that both lectins can bind to a glycan within the RBD-ACE2 interface and thus interferes with Spike binding to cell surfaces.	Polysaccharides	52-58	angiotensin converting enzyme 2	Homo sapiens	74-78
34388530-10	2021	Theaflavin 3-gallate can inhibit the binding between ACE2 and wild-type RBD spike protein.	Theaflavin 3-gallate	0-20	angiotensin converting enzyme 2	Homo sapiens	53-57
34393265-11	2021	We also observed that a Fluoride based compound: 3-(3-(Trifluoromethyl)phenyl)quinoline helps the inhibitor to bind with both Spike-ACE2 and TMPRSS2 with equal probability.	3-[3-(Trifluoromethyl)phenyl]quinoline	49-87	angiotensin converting enzyme 2	Homo sapiens	132-136
34820310-8	2021	This investigation found that, in the molecular docking simulation, the anthocyanin and ternatin showed producing the negative binding affinity to the ACE2 domain which interacted with RBD glycoprotein SARS-CoV-2.	Anthocyanins	72-83	angiotensin converting enzyme 2	Homo sapiens	151-155
34820310-8	2021	This investigation found that, in the molecular docking simulation, the anthocyanin and ternatin showed producing the negative binding affinity to the ACE2 domain which interacted with RBD glycoprotein SARS-CoV-2.	Ternatin	88-96	angiotensin converting enzyme 2	Homo sapiens	151-155
34393265-8	2021	We tested the stability of the docked complexes by running Molecular Dynamics (MD) simulations where we observed the stability of the quinoline analogues with the Spike-ACE2 and TMPRSS2 nevertheless the quinolines were not stable with the Spike protein alone.	quinoline	134-143	angiotensin converting enzyme 2	Homo sapiens	169-173
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	allicin	262-269	angiotensin converting enzyme 2	Homo sapiens	225-229
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	Capsaicin	271-280	angiotensin converting enzyme 2	Homo sapiens	225-229
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	cinnamaldehyde	282-296	angiotensin converting enzyme 2	Homo sapiens	225-229
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	Curcumin	298-306	angiotensin converting enzyme 2	Homo sapiens	225-229
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	gingerol	308-316	angiotensin converting enzyme 2	Homo sapiens	225-229
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	piperine	318-326	angiotensin converting enzyme 2	Homo sapiens	225-229
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	zingeberene	331-342	angiotensin converting enzyme 2	Homo sapiens	225-229
34481181-10	2021	RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry.	Curcumin	40-48	angiotensin converting enzyme 2	Homo sapiens	87-91
34481181-10	2021	RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry.	Curcumin	40-48	angiotensin converting enzyme 2	Homo sapiens	126-130
34481181-10	2021	RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry.	piperine	53-61	angiotensin converting enzyme 2	Homo sapiens	87-91
34481181-10	2021	RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry.	piperine	53-61	angiotensin converting enzyme 2	Homo sapiens	126-130
34537245-4	2021	In contrast, Sb68 interacts at the periphery of the SARS-CoV-2 RBC/ACE2 interface.	sb68	13-17	angiotensin converting enzyme 2	Homo sapiens	67-71
34393265-11	2021	We also observed that a Fluoride based compound: 3-(3-(Trifluoromethyl)phenyl)quinoline helps the inhibitor to bind with both Spike-ACE2 and TMPRSS2 with equal probability.	Fluorides	24-32	angiotensin converting enzyme 2	Homo sapiens	132-136
34403732-7	2021	Interestingly, EGCG, Bkc and Ibvc bind to ACE2 receptor in BLI assay, suggesting a dual binding to RBD and ACE2.	epigallocatechin gallate	15-19	angiotensin converting enzyme 2	Homo sapiens	42-46
34249143-10	2021	With hACE2 transgenic mice, Ag-TiO2 SAN showed efficient anti-SARS-CoV2 pseudovirus activity.	titanium dioxide	31-35	angiotensin converting enzyme 2	Homo sapiens	5-10
34326009-5	2021	RESULTS: Docking rilpivirine with main protease (Mpro), papin like protease (PLpro), sprike protein (Spro), human angiotensin converting enzyme-2 (ACE2), and RNA dependent-RNA polymerase (RdRp) yielded binding energies of -8.07, -8.40, -7.55, -9.11, and -8.69 kcal/mol, respectively.	Rilpivirine	17-28	angiotensin converting enzyme 2	Homo sapiens	114-145
34326009-5	2021	RESULTS: Docking rilpivirine with main protease (Mpro), papin like protease (PLpro), sprike protein (Spro), human angiotensin converting enzyme-2 (ACE2), and RNA dependent-RNA polymerase (RdRp) yielded binding energies of -8.07, -8.40, -7.55, -9.11, and -8.69 kcal/mol, respectively.	Rilpivirine	17-28	angiotensin converting enzyme 2	Homo sapiens	147-151
34326009-6	2021	The electrostatic interaction is the key force in stabilizing the RdRp-rilpivirine complex, while van der Waals interaction dominates in the ACE2 rilpivirine case.	Rilpivirine	146-157	angiotensin converting enzyme 2	Homo sapiens	141-145
34326009-7	2021	Our findings suggest that rilpivirine can inhibit SARS-CoV-2 replication by targeting not only ACE2, but also RdRp and other targets, and therefore, it can be used to invoke altered mechanisms at the pre-entry and post-entry phases.	Rilpivirine	26-37	angiotensin converting enzyme 2	Homo sapiens	95-99
34403732-7	2021	Interestingly, EGCG, Bkc and Ibvc bind to ACE2 receptor in BLI assay, suggesting a dual binding to RBD and ACE2.	epigallocatechin gallate	15-19	angiotensin converting enzyme 2	Homo sapiens	107-111
34403732-7	2021	Interestingly, EGCG, Bkc and Ibvc bind to ACE2 receptor in BLI assay, suggesting a dual binding to RBD and ACE2.	bakuchiol	21-24	angiotensin converting enzyme 2	Homo sapiens	42-46
34403732-7	2021	Interestingly, EGCG, Bkc and Ibvc bind to ACE2 receptor in BLI assay, suggesting a dual binding to RBD and ACE2.	bakuchiol	21-24	angiotensin converting enzyme 2	Homo sapiens	107-111
34403732-7	2021	Interestingly, EGCG, Bkc and Ibvc bind to ACE2 receptor in BLI assay, suggesting a dual binding to RBD and ACE2.	isobavachalcone	29-33	angiotensin converting enzyme 2	Homo sapiens	42-46
34403732-7	2021	Interestingly, EGCG, Bkc and Ibvc bind to ACE2 receptor in BLI assay, suggesting a dual binding to RBD and ACE2.	isobavachalcone	29-33	angiotensin converting enzyme 2	Homo sapiens	107-111
34282808-12	2021	ACE2 expression was suppressed in ENP tissues; however, a combination of poly(I:C) and IL-13 induced ACE2/TMPRSS2 upregulation in ENP.	Poly I-C	73-82	angiotensin converting enzyme 2	Homo sapiens	101-105
34472141-9	2021	As a result, pseudoephedrine (MHJ-17) and its derivative (MHJ-11) were found as efficient inhibitors disrupting the interactions between ACE2 and both wild and mutated S-RBDs.	Pseudoephedrine	13-28	angiotensin converting enzyme 2	Homo sapiens	137-141
34428371-10	2021	The DFT results reveal that N487, Q493, Y449, T500, G496, G446, and G502 in RBD of SARS2 form pairs via specific hydrogen bonding with Q24, H34, E35, D38, Y41, Q42, and K353 in ACE2.	Hydrogen	113-121	angiotensin converting enzyme 2	Homo sapiens	177-181
34733553-13	2021	ACE2 expression slightly increased in CRL-127 post RA-treatment.	Tretinoin	51-53	angiotensin converting enzyme 2	Homo sapiens	0-4
34124808-8	2021	Strikingly, we found that the protective effects of hPMSC in MCAO-induced brain injury could be attenuated by pretreatment of hPMSCs with MLN-4760, a specific inhibitor of ACE-2 activity, or by transfection of hPMSCs with ACE-2-shRNA-lentivirus.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	138-146	angiotensin converting enzyme 2	Homo sapiens	172-177
34124808-9	2021	The hPMSC-derived ACE-2 specific protective mechanism was further demonstrated by administration of PD123319, an AT2 receptor antagonist, or A779, a MasR antagonist.	PD 123319	100-108	angiotensin converting enzyme 2	Homo sapiens	18-23
34638785-2	2021	We previously reported that in non-neural cells, angiotensin-1 converting enzyme 2 (ACE2), the gene coding for the SARS-CoV2 host receptor, harbors tight co-expression links with dopa-decarboxylase (DDC), an enzyme involved in the metabolism of dopamine.	Dopamine	245-253	angiotensin converting enzyme 2	Homo sapiens	84-88
34638785-5	2021	We observed that in SARS-CoV2-infected enterocytes, ACE2 co-regulates not only with DDC but also with a specific group of genes involved in (i) the dopamine/trace amines metabolic pathway, (ii) the absorption of microbiota-derived L-DOPA and (iii) the absorption of neutral amino acids serving as precursors to neurotransmitters.	Dopamine	148-156	angiotensin converting enzyme 2	Homo sapiens	52-56
34638785-5	2021	We observed that in SARS-CoV2-infected enterocytes, ACE2 co-regulates not only with DDC but also with a specific group of genes involved in (i) the dopamine/trace amines metabolic pathway, (ii) the absorption of microbiota-derived L-DOPA and (iii) the absorption of neutral amino acids serving as precursors to neurotransmitters.	Amines	163-169	angiotensin converting enzyme 2	Homo sapiens	52-56
34638785-5	2021	We observed that in SARS-CoV2-infected enterocytes, ACE2 co-regulates not only with DDC but also with a specific group of genes involved in (i) the dopamine/trace amines metabolic pathway, (ii) the absorption of microbiota-derived L-DOPA and (iii) the absorption of neutral amino acids serving as precursors to neurotransmitters.	Levodopa	231-237	angiotensin converting enzyme 2	Homo sapiens	52-56
34638785-5	2021	We observed that in SARS-CoV2-infected enterocytes, ACE2 co-regulates not only with DDC but also with a specific group of genes involved in (i) the dopamine/trace amines metabolic pathway, (ii) the absorption of microbiota-derived L-DOPA and (iii) the absorption of neutral amino acids serving as precursors to neurotransmitters.	Amino Acids, Neutral	266-285	angiotensin converting enzyme 2	Homo sapiens	52-56
34569409-3	2021	Among the 44 studied compounds, 37 polyphenols show interaction with the catalytic dyad of the Mpro protease and 18 polyphenols have a higher binding affinity than that of the Mpro protease inhibitor (N3), indicating their high probability of binding at ACE2: SARS-CoV-2 interface.	Polyphenols	35-46	angiotensin converting enzyme 2	Homo sapiens	254-258
34569409-3	2021	Among the 44 studied compounds, 37 polyphenols show interaction with the catalytic dyad of the Mpro protease and 18 polyphenols have a higher binding affinity than that of the Mpro protease inhibitor (N3), indicating their high probability of binding at ACE2: SARS-CoV-2 interface.	Polyphenols	116-127	angiotensin converting enzyme 2	Homo sapiens	254-258
34491043-5	2021	To improve selectivity in complex biological environments, we have employed peptides as capture probes for viral proteins and developed an angiotensin-converting enzyme 2 (ACE2) mimetic peptide-based SERS sensor for SARS-CoV-2.	Peptides	186-193	angiotensin converting enzyme 2	Homo sapiens	139-170
34646813-4	2021	In this study, we described the virtual screening and experimental validation of two novel inhibitors (DC-RA016 and DC-RA052) against SARS-CoV-2 S-RBD/ACE2 interaction.	dc-ra016	103-111	angiotensin converting enzyme 2	Homo sapiens	151-155
34646813-4	2021	In this study, we described the virtual screening and experimental validation of two novel inhibitors (DC-RA016 and DC-RA052) against SARS-CoV-2 S-RBD/ACE2 interaction.	dc-ra052	116-124	angiotensin converting enzyme 2	Homo sapiens	151-155
34646813-7	2021	These results indicate that the compounds DC-RA016 and DC-RA052 are promising inhibitors against SARS-CoV-2 S-RBD/ACE2 interaction and deserve to be further developed.	dc-ra016	42-50	angiotensin converting enzyme 2	Homo sapiens	114-118
34646813-7	2021	These results indicate that the compounds DC-RA016 and DC-RA052 are promising inhibitors against SARS-CoV-2 S-RBD/ACE2 interaction and deserve to be further developed.	dc-ra052	55-63	angiotensin converting enzyme 2	Homo sapiens	114-118
34646263-11	2021	The sartans (olmesartan and losartan) showed non-statistically significant ACE2 modulation in Calu-3 and endothelial cells, as compared to untreated control cells.	olmesartan	13-23	angiotensin converting enzyme 2	Homo sapiens	75-79
34646263-11	2021	The sartans (olmesartan and losartan) showed non-statistically significant ACE2 modulation in Calu-3 and endothelial cells, as compared to untreated control cells.	Losartan	28-36	angiotensin converting enzyme 2	Homo sapiens	75-79
34646263-12	2021	We observed that the antidiabetic biguanide metformin, a putative anti-inflammatory agent, also upregulates ACE2 expression in Calu-3 and endothelial cells.	Biguanides	34-43	angiotensin converting enzyme 2	Homo sapiens	108-112
34646263-12	2021	We observed that the antidiabetic biguanide metformin, a putative anti-inflammatory agent, also upregulates ACE2 expression in Calu-3 and endothelial cells.	Metformin	44-53	angiotensin converting enzyme 2	Homo sapiens	108-112
34491043-5	2021	To improve selectivity in complex biological environments, we have employed peptides as capture probes for viral proteins and developed an angiotensin-converting enzyme 2 (ACE2) mimetic peptide-based SERS sensor for SARS-CoV-2.	Peptides	186-193	angiotensin converting enzyme 2	Homo sapiens	172-176
34491043-5	2021	To improve selectivity in complex biological environments, we have employed peptides as capture probes for viral proteins and developed an angiotensin-converting enzyme 2 (ACE2) mimetic peptide-based SERS sensor for SARS-CoV-2.	sers	200-204	angiotensin converting enzyme 2	Homo sapiens	139-170
34491043-5	2021	To improve selectivity in complex biological environments, we have employed peptides as capture probes for viral proteins and developed an angiotensin-converting enzyme 2 (ACE2) mimetic peptide-based SERS sensor for SARS-CoV-2.	sers	200-204	angiotensin converting enzyme 2	Homo sapiens	172-176
34554412-4	2021	Structural analyses reveal that XG014 recognizes a conserved epitope outside the ACE2 binding site and completely locks RBD in the non-functional "down" conformation, while its family member XG005 directly competes with ACE2 binding and position the RBD "up".	xg014	32-37	angiotensin converting enzyme 2	Homo sapiens	81-85
34565075-6	2021	The ACE2/Ang-(1-7)/Mas axis can enhance glucose tolerance and improve insulin sensitivity by protecting pancreatic beta cells, increasing insulin secretion, improving glucose metabolism in adipose tissue, enhancing glucose uptake by skeletal muscle, and inhibiting hepatic gluconeogenesis.	Glucose	215-222	angiotensin converting enzyme 2	Homo sapiens	4-8
34578240-0	2021	Evaluation of Inhibitory Activity In Silico of In-House Thiomorpholine Compounds between the ACE2 Receptor and S1 Subunit of SARS-CoV-2 Spike.	thiamorpholine	56-70	angiotensin converting enzyme 2	Homo sapiens	93-97
34681178-4	2021	Virtual screening indicated pyronaridine as the most promising RBD and ACE2 ligand, and molecular dynamics simulations confirmed the stability of the predicted complex with the RBD.	pyronaridine	28-40	angiotensin converting enzyme 2	Homo sapiens	71-75
34681178-6	2021	Pyronaridine also binds RBD and ACE2 in vitro (KD = 56.8 and 51.3 muM).	pyronaridine	0-12	angiotensin converting enzyme 2	Homo sapiens	32-36
34308375-4	2021	Here we describe an optimized protocol for immunostaining of ACE2 in formalin fixed paraffin embedded human (FFPE) pancreas, small intestine and kidney tissue sections obtained from organ donors and autopsies.	Formaldehyde	69-77	angiotensin converting enzyme 2	Homo sapiens	61-65
34308375-4	2021	Here we describe an optimized protocol for immunostaining of ACE2 in formalin fixed paraffin embedded human (FFPE) pancreas, small intestine and kidney tissue sections obtained from organ donors and autopsies.	Paraffin	84-92	angiotensin converting enzyme 2	Homo sapiens	61-65
34518836-6	2021	Molecular dynamics simulations were performed using NAMD to investigate the hydrogen bonds between S proteins and hACE2.	Hydrogen	76-84	angiotensin converting enzyme 2	Homo sapiens	114-119
34529322-5	2022	In addition, following 3 compounds were identified as inhibitors for Spike/ACE2: Denopamine, bometolol, and rotigaptide.	denopamine	81-91	angiotensin converting enzyme 2	Homo sapiens	75-79
34529322-5	2022	In addition, following 3 compounds were identified as inhibitors for Spike/ACE2: Denopamine, bometolol, and rotigaptide.	bometolol	93-102	angiotensin converting enzyme 2	Homo sapiens	75-79
34529322-5	2022	In addition, following 3 compounds were identified as inhibitors for Spike/ACE2: Denopamine, bometolol, and rotigaptide.	rotigaptide	108-119	angiotensin converting enzyme 2	Homo sapiens	75-79
34529322-7	2022	While the concentration-dependent inhibition of the ritonavir, rotigaptide, and cefotiam was observed for the main protease; denopamine was effective at the inhibition of Spike/ACE2 binding.	denopamine	125-135	angiotensin converting enzyme 2	Homo sapiens	177-181
34453881-2	2021	Here, we applied live bioluminescence imaging (BLI) to monitor the real-time effects of NAb treatment during prophylaxis and therapy of K18-hACE2 mice intranasally infected with SARS-CoV-2-nanoluciferase.	nab	88-91	angiotensin converting enzyme 2	Homo sapiens	140-145
34499662-0	2021	Machine Learning augmented docking studies of aminothioureas at the SARS-CoV-2-ACE2 interface.	aminothioureas	46-60	angiotensin converting enzyme 2	Homo sapiens	79-83
34499662-3	2021	In this contribution, we focus on the comparison of the results obtained using different docking protocols on the example of the search for bioactivity of compounds containing N-N-C(S)-N scaffold at the S-protein of SARS-CoV-2 virus with ACE2 human receptor interface.	Tin	181-186	angiotensin converting enzyme 2	Homo sapiens	238-242
34619934-5	2021	The protein expressions of complement factor I (CFI), angiotensin converting enzyme 2 (ACE2) and protein C inhibitor (SERPINA5) were positively correlated with daily alcohol consumption.	Alcohols	166-173	angiotensin converting enzyme 2	Homo sapiens	54-85
34111397-6	2021	In target-centered in silico studies, leflunomide showed favorable binding to active site of MPro and spike: ACE2 interface.	Leflunomide	38-49	angiotensin converting enzyme 2	Homo sapiens	109-113
34111397-7	2021	In artificial-intelligence/machine-learning based studies, leflunomide was among the top 50 ligands targeting spike: ACE2 interaction.	Leflunomide	59-70	angiotensin converting enzyme 2	Homo sapiens	117-121
34619934-5	2021	The protein expressions of complement factor I (CFI), angiotensin converting enzyme 2 (ACE2) and protein C inhibitor (SERPINA5) were positively correlated with daily alcohol consumption.	Alcohols	166-173	angiotensin converting enzyme 2	Homo sapiens	87-91
34493899-14	2021	Pretreatment of AngII and LPS regulated the activity of ACE2, increased the expression of proinflammatory cytokines and cell apoptosis and regulated the expression of Bax, Bcl-2 and cleaved caspase-3 in BEAS-2B cells, which could be reversed by transfecting miR-143-3p inhibitor.	mir-143-3p	258-268	angiotensin converting enzyme 2	Homo sapiens	56-60
34174588-4	2021	RESULTS: The expression for ACE2 in HGnF was significantly elevated after PgLPS or IL1beta, TNFalpha, PGE2 treatment.	Dinoprostone	102-106	angiotensin converting enzyme 2	Homo sapiens	28-32
34479494-3	2021	Se and Zn deficiency might lead to inflammation, oxidative stress, and viral entry into the cells by decreasing ACE-2 expression; three factors that are proposed to be involved in COVID-19 pathogenesis.	Zinc	7-9	angiotensin converting enzyme 2	Homo sapiens	112-117
34574194-5	2021	Some of these compounds (e.g., curcumin, gallic acid or quercetin) already showed capacity to limit the infection of viruses by inhibiting entry into the cell through its binding to protein Spike, regulating the expression of angiotensin-converting enzyme 2, disrupting the replication in cells by inhibition of viral proteases, and/or suppressing and modulating the host"s immune response.	Curcumin	31-39	angiotensin converting enzyme 2	Homo sapiens	226-257
34574194-5	2021	Some of these compounds (e.g., curcumin, gallic acid or quercetin) already showed capacity to limit the infection of viruses by inhibiting entry into the cell through its binding to protein Spike, regulating the expression of angiotensin-converting enzyme 2, disrupting the replication in cells by inhibition of viral proteases, and/or suppressing and modulating the host"s immune response.	Gallic Acid	41-52	angiotensin converting enzyme 2	Homo sapiens	226-257
34574194-5	2021	Some of these compounds (e.g., curcumin, gallic acid or quercetin) already showed capacity to limit the infection of viruses by inhibiting entry into the cell through its binding to protein Spike, regulating the expression of angiotensin-converting enzyme 2, disrupting the replication in cells by inhibition of viral proteases, and/or suppressing and modulating the host"s immune response.	Quercetin	56-65	angiotensin converting enzyme 2	Homo sapiens	226-257
34420372-7	2021	P-ACE2 was significantly lower in subjects treated with renin-angiotensin-aldosterone system inhibitors than in those not treated with renin-angiotensin-aldosterone system inhibitors, but there was no significant difference in U-ACE2 between the groups.	Aldosterone	74-85	angiotensin converting enzyme 2	Homo sapiens	2-6
34146659-7	2021	The upregulated ACE2 induced by TRIM28 knockdown and co-culture of NK cells was partially reversed by dexamethasone in A549 cells.	Dexamethasone	102-115	angiotensin converting enzyme 2	Homo sapiens	16-20
34518806-5	2021	Among the 16 HCV DAA drugs, telaprevir has shown the best in silico evidence to work on both indirect human targets (cathepsin L (CTSL) and human angiotensin-converting enzyme 2 (hACE2) receptor) and direct viral targets (main protease (Mpro)).	telaprevir	28-38	angiotensin converting enzyme 2	Homo sapiens	146-177
34518806-5	2021	Among the 16 HCV DAA drugs, telaprevir has shown the best in silico evidence to work on both indirect human targets (cathepsin L (CTSL) and human angiotensin-converting enzyme 2 (hACE2) receptor) and direct viral targets (main protease (Mpro)).	telaprevir	28-38	angiotensin converting enzyme 2	Homo sapiens	179-184
34824739-5	2021	The present in silico study evaluated the binding affinities of some natural products (resveratrol, xylopic acid, ellagic acid, kaempferol, and quercetin) to human angiotensin-converting enzyme 2 and coronavirus (SARS-CoV-2) main protease compared to chloroquine, an inhibitor known to prevent cellular entry and replication of the coronavirus.	Resveratrol	87-98	angiotensin converting enzyme 2	Homo sapiens	164-195
34824739-5	2021	The present in silico study evaluated the binding affinities of some natural products (resveratrol, xylopic acid, ellagic acid, kaempferol, and quercetin) to human angiotensin-converting enzyme 2 and coronavirus (SARS-CoV-2) main protease compared to chloroquine, an inhibitor known to prevent cellular entry and replication of the coronavirus.	Ellagic Acid	114-126	angiotensin converting enzyme 2	Homo sapiens	164-195
34824739-5	2021	The present in silico study evaluated the binding affinities of some natural products (resveratrol, xylopic acid, ellagic acid, kaempferol, and quercetin) to human angiotensin-converting enzyme 2 and coronavirus (SARS-CoV-2) main protease compared to chloroquine, an inhibitor known to prevent cellular entry and replication of the coronavirus.	kaempferol	128-138	angiotensin converting enzyme 2	Homo sapiens	164-195
34824739-5	2021	The present in silico study evaluated the binding affinities of some natural products (resveratrol, xylopic acid, ellagic acid, kaempferol, and quercetin) to human angiotensin-converting enzyme 2 and coronavirus (SARS-CoV-2) main protease compared to chloroquine, an inhibitor known to prevent cellular entry and replication of the coronavirus.	Quercetin	144-153	angiotensin converting enzyme 2	Homo sapiens	164-195
34246969-0	2021	Pomegranate peel extract polyphenols attenuate the SARS-CoV-2 S-glycoprotein binding ability to ACE2 Receptor: In silico and in vitro studies.	Polyphenols	25-36	angiotensin converting enzyme 2	Homo sapiens	96-100
34246969-4	2021	In this study, both in silico and in vitro methods were employed for evaluation of pomegranate peel extract (PoPEx), their major polyphenols, as well as their major metabolite urolithin A, to attenuate the contact of S-glycoprotein RBD and ACE2.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	176-187	angiotensin converting enzyme 2	Homo sapiens	240-244
34246969-5	2021	Our results showed that PoPEx, punicalin, punicalagin and urolithin A exerted significant potential to block the S-glycoprotein-ACE2 contact.	punicalin	31-40	angiotensin converting enzyme 2	Homo sapiens	128-132
34246969-5	2021	Our results showed that PoPEx, punicalin, punicalagin and urolithin A exerted significant potential to block the S-glycoprotein-ACE2 contact.	punicalagin	42-53	angiotensin converting enzyme 2	Homo sapiens	128-132
34246969-5	2021	Our results showed that PoPEx, punicalin, punicalagin and urolithin A exerted significant potential to block the S-glycoprotein-ACE2 contact.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	58-69	angiotensin converting enzyme 2	Homo sapiens	128-132
34420372-10	2021	U-ACE2 is associated with high blood pressure, high glucose level, and microalbuminuria, and low urate level, whereas P-ACE2 is associated with liver dysfunction, high glomerular filtration rate, and high urate level.	Glucose	52-59	angiotensin converting enzyme 2	Homo sapiens	2-6
34420372-10	2021	U-ACE2 is associated with high blood pressure, high glucose level, and microalbuminuria, and low urate level, whereas P-ACE2 is associated with liver dysfunction, high glomerular filtration rate, and high urate level.	Uric Acid	97-102	angiotensin converting enzyme 2	Homo sapiens	2-6
34420372-10	2021	U-ACE2 is associated with high blood pressure, high glucose level, and microalbuminuria, and low urate level, whereas P-ACE2 is associated with liver dysfunction, high glomerular filtration rate, and high urate level.	Uric Acid	205-210	angiotensin converting enzyme 2	Homo sapiens	120-124
34392451-5	2021	SARS-CoV-2 cell entry through angiotensin-converting enzyme 2 (ACE2) may enhance the activity of renin-angiotensin-aldosterone system (RAAS) classical axis and further leading to over production of aldosterone.	Aldosterone	115-126	angiotensin converting enzyme 2	Homo sapiens	30-61
34312610-5	2021	Moreover, crocin appears to reduce the COVID-19-related cytokine cascade and downregulate angiotensin-converting enzyme 2 (ACE2) gene expression.	crocin	10-16	angiotensin converting enzyme 2	Homo sapiens	90-121
34312610-5	2021	Moreover, crocin appears to reduce the COVID-19-related cytokine cascade and downregulate angiotensin-converting enzyme 2 (ACE2) gene expression.	crocin	10-16	angiotensin converting enzyme 2	Homo sapiens	123-127
34171382-7	2021	KEY FINDINGS: Pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, suppressed endogenous ACE2 mRNA and protein expression in H322M and Calu-3 cells.	pyrrolidine dithiocarbamic acid	14-41	angiotensin converting enzyme 2	Homo sapiens	96-100
34171382-7	2021	KEY FINDINGS: Pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, suppressed endogenous ACE2 mRNA and protein expression in H322M and Calu-3 cells.	pyrrolidine dithiocarbamic acid	43-47	angiotensin converting enzyme 2	Homo sapiens	96-100
34171382-8	2021	The ROS level in H322M cells was increased after PDTC treatment, and pretreatment with N-acetyl-cysteine (NAC) reversed PDTC-induced ACE2 suppression.	pyrrolidine dithiocarbamic acid	49-53	angiotensin converting enzyme 2	Homo sapiens	133-137
34171382-8	2021	The ROS level in H322M cells was increased after PDTC treatment, and pretreatment with N-acetyl-cysteine (NAC) reversed PDTC-induced ACE2 suppression.	Acetylcysteine	87-104	angiotensin converting enzyme 2	Homo sapiens	133-137
34171382-8	2021	The ROS level in H322M cells was increased after PDTC treatment, and pretreatment with N-acetyl-cysteine (NAC) reversed PDTC-induced ACE2 suppression.	Acetylcysteine	106-109	angiotensin converting enzyme 2	Homo sapiens	133-137
34171382-8	2021	The ROS level in H322M cells was increased after PDTC treatment, and pretreatment with N-acetyl-cysteine (NAC) reversed PDTC-induced ACE2 suppression.	pyrrolidine dithiocarbamic acid	120-124	angiotensin converting enzyme 2	Homo sapiens	133-137
34171382-9	2021	Meanwhile, treatment with hydrogen peroxide augmented ACE2 suppression in H322M cells with p50 knockdown.	Hydrogen Peroxide	26-43	angiotensin converting enzyme 2	Homo sapiens	54-58
34171382-10	2021	Two repurposed NF-kappaB inhibitors, the anthelmintic drug triclabendazole and the antiprotozoal drug emetine, also reduced ACE2 mRNA and protein levels.	Triclabendazole	59-74	angiotensin converting enzyme 2	Homo sapiens	124-128
34171382-10	2021	Two repurposed NF-kappaB inhibitors, the anthelmintic drug triclabendazole and the antiprotozoal drug emetine, also reduced ACE2 mRNA and protein levels.	Emetine	102-109	angiotensin converting enzyme 2	Homo sapiens	124-128
34171382-11	2021	Moreover, zinc supplementation augmented the suppressive effects of triclabendazole and emetine on ACE2 expression in H322M and Calu-3 cells.	Triclabendazole	68-83	angiotensin converting enzyme 2	Homo sapiens	99-103
34171382-11	2021	Moreover, zinc supplementation augmented the suppressive effects of triclabendazole and emetine on ACE2 expression in H322M and Calu-3 cells.	Emetine	88-95	angiotensin converting enzyme 2	Homo sapiens	99-103
34171382-12	2021	SIGNIFICANCE: These results suggest that ACE2 expression is modulated by ROS and NF-kappaB signaling in human lung cells, and the combination of zinc with triclabendazole or emetine shows promise for clinical treatment of ACE2-related disease.	Reactive Oxygen Species	73-76	angiotensin converting enzyme 2	Homo sapiens	41-45
34171382-12	2021	SIGNIFICANCE: These results suggest that ACE2 expression is modulated by ROS and NF-kappaB signaling in human lung cells, and the combination of zinc with triclabendazole or emetine shows promise for clinical treatment of ACE2-related disease.	Triclabendazole	155-170	angiotensin converting enzyme 2	Homo sapiens	41-45
34171382-12	2021	SIGNIFICANCE: These results suggest that ACE2 expression is modulated by ROS and NF-kappaB signaling in human lung cells, and the combination of zinc with triclabendazole or emetine shows promise for clinical treatment of ACE2-related disease.	Emetine	174-181	angiotensin converting enzyme 2	Homo sapiens	41-45
34392451-5	2021	SARS-CoV-2 cell entry through angiotensin-converting enzyme 2 (ACE2) may enhance the activity of renin-angiotensin-aldosterone system (RAAS) classical axis and further leading to over production of aldosterone.	Aldosterone	115-126	angiotensin converting enzyme 2	Homo sapiens	63-67
34392451-5	2021	SARS-CoV-2 cell entry through angiotensin-converting enzyme 2 (ACE2) may enhance the activity of renin-angiotensin-aldosterone system (RAAS) classical axis and further leading to over production of aldosterone.	Aldosterone	198-209	angiotensin converting enzyme 2	Homo sapiens	30-61
34392451-5	2021	SARS-CoV-2 cell entry through angiotensin-converting enzyme 2 (ACE2) may enhance the activity of renin-angiotensin-aldosterone system (RAAS) classical axis and further leading to over production of aldosterone.	Aldosterone	198-209	angiotensin converting enzyme 2	Homo sapiens	63-67
34578326-4	2021	Doxycycline inhibited the transduction of the pseudotyped virus in Vero E6 and HEK-293 T cells stably expressing human receptor angiotensin-converting enzyme 2 but did not affect the entry and replication of SARS-CoV-2.	Doxycycline	0-11	angiotensin converting enzyme 2	Homo sapiens	128-159
34508344-9	2021	In combination with vitamin D, flavonoids possibly activate nuclear factor erythroid-derived-2-related factor 2 that downregulates ACE2 expression in cells.	Vitamin D	20-29	angiotensin converting enzyme 2	Homo sapiens	131-135
34508344-9	2021	In combination with vitamin D, flavonoids possibly activate nuclear factor erythroid-derived-2-related factor 2 that downregulates ACE2 expression in cells.	Flavonoids	31-41	angiotensin converting enzyme 2	Homo sapiens	131-135
34357376-7	2021	In summary, our study suggests that liraglutide or alogliptin protects the heart against cardiac hypertrophy by regulating the expression of AngII/AT1R/ACE2 and activating the AMPK/mTOR pathway, and GLP-1 agonist can be used in the treatment of patients with cardiac hypertrophy.	alogliptin	51-61	angiotensin converting enzyme 2	Homo sapiens	152-156
34340553-8	2021	In mice sensitized to SARS-CoV-2 infection by transduction with human ACE2, intranasal nafamostat treatment prior to or shortly after SARS-CoV-2 infection significantly reduced weight loss and lung tissue titers.	nafamostat	87-97	angiotensin converting enzyme 2	Homo sapiens	70-74
34340553-9	2021	Similarly, prophylactic intranasal treatment with nafamostat reduced weight loss, viral burden, and mortality in K18-hACE2 transgenic mice.	nafamostat	50-60	angiotensin converting enzyme 2	Homo sapiens	117-122
34461999-0	2021	Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor.	epigallocatechin gallate	0-24	angiotensin converting enzyme 2	Homo sapiens	131-135
34461999-8	2021	Mechanistic studies revealed that EGCG blocked infection at the entry step through interfering with the engagement of the receptor binding domain (RBD) of the viral spikes to angiotensin-converting enzyme 2 (ACE2) receptor of the host cells.	epigallocatechin gallate	34-38	angiotensin converting enzyme 2	Homo sapiens	175-206
34461999-8	2021	Mechanistic studies revealed that EGCG blocked infection at the entry step through interfering with the engagement of the receptor binding domain (RBD) of the viral spikes to angiotensin-converting enzyme 2 (ACE2) receptor of the host cells.	epigallocatechin gallate	34-38	angiotensin converting enzyme 2	Homo sapiens	208-212
34308004-11	2021	Ligands that bound all target proteins, and showed the lowest binding energies with good ADMET properties and particularly showed the lowest binding against ACE2 are ethynodiol diacetate (-15.6 kcal/mol), methylnaltrexone (-15.5 kcal/mol), ketazolam (-14.5 kcal/mol) and naloxone (-13.6 kcal/mol).	Ethynodiol Diacetate	166-186	angiotensin converting enzyme 2	Homo sapiens	157-161
34308004-11	2021	Ligands that bound all target proteins, and showed the lowest binding energies with good ADMET properties and particularly showed the lowest binding against ACE2 are ethynodiol diacetate (-15.6 kcal/mol), methylnaltrexone (-15.5 kcal/mol), ketazolam (-14.5 kcal/mol) and naloxone (-13.6 kcal/mol).	methylnaltrexone	205-221	angiotensin converting enzyme 2	Homo sapiens	157-161
34577585-8	2021	A biolayer interfero-metry (BLI) binding assay and molecular docking study revealed that 6p binds to human ACE2 protein with higher binding affinity and lower binding energy than the parental honokiol.	honokiol	192-200	angiotensin converting enzyme 2	Homo sapiens	107-111
34577585-9	2021	A competitive ELISA assay confirmed the inhibitory effect of 6p on SARS-CoV-2 spike RBD"s binding with ACE2.	6p	61-63	angiotensin converting enzyme 2	Homo sapiens	103-107
34483461-3	2021	Another objective is to analyze the effects of binding Dex and Boc drugs on the interactions of viral spike protein to human angiotensin-converting enzyme 2 (hACE2).	Dexamethasone	55-58	angiotensin converting enzyme 2	Homo sapiens	125-156
34483461-3	2021	Another objective is to analyze the effects of binding Dex and Boc drugs on the interactions of viral spike protein to human angiotensin-converting enzyme 2 (hACE2).	Dexamethasone	55-58	angiotensin converting enzyme 2	Homo sapiens	158-163
34483461-3	2021	Another objective is to analyze the effects of binding Dex and Boc drugs on the interactions of viral spike protein to human angiotensin-converting enzyme 2 (hACE2).	N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide	63-66	angiotensin converting enzyme 2	Homo sapiens	125-156
34483461-3	2021	Another objective is to analyze the effects of binding Dex and Boc drugs on the interactions of viral spike protein to human angiotensin-converting enzyme 2 (hACE2).	N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide	63-66	angiotensin converting enzyme 2	Homo sapiens	158-163
34575637-11	2021	We further showed that the natural flavonoid luteolin is a potent inhibitor of the activation of both mast cells and microglia, but also blocks SARS-CoV-2 binding to its receptor angiotensin-converting enzyme 2 (ACE2).	Flavonoids	35-44	angiotensin converting enzyme 2	Homo sapiens	179-210
34501332-3	2021	Based on this purported ACE2 double function, it has been put forward that the benefit from ACE2 upregulation with renin-angiotensin-aldosterone system inhibitors (RAASi) counterbalances COVID-19 risks due to counter-regulatory RAS axis amplification.	Aldosterone	133-144	angiotensin converting enzyme 2	Homo sapiens	24-28
34501332-3	2021	Based on this purported ACE2 double function, it has been put forward that the benefit from ACE2 upregulation with renin-angiotensin-aldosterone system inhibitors (RAASi) counterbalances COVID-19 risks due to counter-regulatory RAS axis amplification.	Aldosterone	133-144	angiotensin converting enzyme 2	Homo sapiens	92-96
34575637-11	2021	We further showed that the natural flavonoid luteolin is a potent inhibitor of the activation of both mast cells and microglia, but also blocks SARS-CoV-2 binding to its receptor angiotensin-converting enzyme 2 (ACE2).	Flavonoids	35-44	angiotensin converting enzyme 2	Homo sapiens	212-216
34803452-0	2021	Targeting CoV-2 spike RBD and ACE-2 interaction with flavonoids of Anatolian propolis by in silico and in vitro studies in terms of possible COVID-19 therapeutics.	Flavonoids	53-63	angiotensin converting enzyme 2	Homo sapiens	30-35
34803452-5	2021	The binding energy values of these polyphenols to the SARS-CoV-2 spike and ACE-2 protein were calculated separately with a molecular docking study using the AutoDock 4.2.6 program.	Polyphenols	35-46	angiotensin converting enzyme 2	Homo sapiens	75-80
34502041-8	2021	Further, we found that the Alpha variant had increased hydrogen interaction with Lys353 of hACE2 and more binding affinity in comparison to WT.	Hydrogen	55-63	angiotensin converting enzyme 2	Homo sapiens	91-96
34351742-0	2021	Aromatic Cadinane Sesquiterpenoids from the Fruiting Bodies of Phellinus pini Block SARS-CoV-2 Spike-ACE2 Interaction.	aromatic cadinane	0-17	angiotensin converting enzyme 2	Homo sapiens	101-105
34351742-0	2021	Aromatic Cadinane Sesquiterpenoids from the Fruiting Bodies of Phellinus pini Block SARS-CoV-2 Spike-ACE2 Interaction.	Sesquiterpenes	18-34	angiotensin converting enzyme 2	Homo sapiens	101-105
34351742-4	2021	All of the aromatic cadinane sesquiterpenoids inhibited the SARS-CoV-2 spike-ACE2 interaction, with IC50 values ranging from 64.5 to 99.1 muM.	cadinane	20-28	angiotensin converting enzyme 2	Homo sapiens	77-81
34351742-4	2021	All of the aromatic cadinane sesquiterpenoids inhibited the SARS-CoV-2 spike-ACE2 interaction, with IC50 values ranging from 64.5 to 99.1 muM.	Sesquiterpenes	29-45	angiotensin converting enzyme 2	Homo sapiens	77-81
34351742-5	2021	A molecular docking study showed the disruption of the interaction of compound 1 via hydrogen interactions with Arg403, Asp405, and Arg408 of SARS-CoV-2 RBD and Arg393 and His34 residues of ACE2.	Hydrogen	85-93	angiotensin converting enzyme 2	Homo sapiens	190-194
34471421-6	2021	The effects of hypoxia and ACE2 on AT II cells were evaluated by MTT, western blot, ELISA, and flow cytometry.	monooxyethylene trimethylolpropane tristearate	65-68	angiotensin converting enzyme 2	Homo sapiens	27-31
34451782-0	2021	Antcins from Antrodia cinnamomea and Antrodia salmonea Inhibit Angiotensin-Converting Enzyme 2 (ACE2) in Epithelial Cells: Can Be Potential Candidates for the Development of SARS-CoV-2 Prophylactic Agents.	antcins	0-7	angiotensin converting enzyme 2	Homo sapiens	96-100
34451782-5	2021	Here, we report a novel function of antcins, in which antcins exhibit inhibitory effects on ACE2.	antcins	36-43	angiotensin converting enzyme 2	Homo sapiens	92-96
34451782-5	2021	Here, we report a novel function of antcins, in which antcins exhibit inhibitory effects on ACE2.	antcins	54-61	angiotensin converting enzyme 2	Homo sapiens	92-96
34451782-6	2021	Compared to the untreated control group, treatment with various antcins (antcin-A, antcin-B, antcin-C, antcin-H, antcin-I, and antcin-M) significantly inhibited ACE2 activity in cultured human epithelial cells.	antcins	64-71	angiotensin converting enzyme 2	Homo sapiens	161-165
34522180-4	2021	In in vitro studies, membrane cholesterol increased the number of viral entry sites on the host cell membrane and the number of angiotensin-converting enzyme 2 (ACE2) receptors in the membrane fusion site.	Cholesterol	30-41	angiotensin converting enzyme 2	Homo sapiens	128-159
34451782-6	2021	Compared to the untreated control group, treatment with various antcins (antcin-A, antcin-B, antcin-C, antcin-H, antcin-I, and antcin-M) significantly inhibited ACE2 activity in cultured human epithelial cells.	antcin A	73-81	angiotensin converting enzyme 2	Homo sapiens	161-165
34451782-6	2021	Compared to the untreated control group, treatment with various antcins (antcin-A, antcin-B, antcin-C, antcin-H, antcin-I, and antcin-M) significantly inhibited ACE2 activity in cultured human epithelial cells.	antcin	83-89	angiotensin converting enzyme 2	Homo sapiens	161-165
34451782-6	2021	Compared to the untreated control group, treatment with various antcins (antcin-A, antcin-B, antcin-C, antcin-H, antcin-I, and antcin-M) significantly inhibited ACE2 activity in cultured human epithelial cells.	antcin	93-99	angiotensin converting enzyme 2	Homo sapiens	161-165
34451782-6	2021	Compared to the untreated control group, treatment with various antcins (antcin-A, antcin-B, antcin-C, antcin-H, antcin-I, and antcin-M) significantly inhibited ACE2 activity in cultured human epithelial cells.	antcin	103-109	angiotensin converting enzyme 2	Homo sapiens	161-165
34451782-6	2021	Compared to the untreated control group, treatment with various antcins (antcin-A, antcin-B, antcin-C, antcin-H, antcin-I, and antcin-M) significantly inhibited ACE2 activity in cultured human epithelial cells.	antcin	113-119	angiotensin converting enzyme 2	Homo sapiens	161-165
34451782-6	2021	Compared to the untreated control group, treatment with various antcins (antcin-A, antcin-B, antcin-C, antcin-H, antcin-I, and antcin-M) significantly inhibited ACE2 activity in cultured human epithelial cells.	antcin-	127-134	angiotensin converting enzyme 2	Homo sapiens	161-165
34451782-7	2021	Indeed, among the investigated antcins, antcin-A, antcin-B, antcin-C, and antcin-I showed a pronounceable inhibition against ACE2.	antcins	31-38	angiotensin converting enzyme 2	Homo sapiens	125-129
34522180-4	2021	In in vitro studies, membrane cholesterol increased the number of viral entry sites on the host cell membrane and the number of angiotensin-converting enzyme 2 (ACE2) receptors in the membrane fusion site.	Cholesterol	30-41	angiotensin converting enzyme 2	Homo sapiens	161-165
34490283-2	2021	Individuals with comorbidities associated with severe COVID-19 display higher levels of ACE2 in the lungs compared to those without comorbidities, and conditions such as cell stress, elevated glucose levels and hypoxia may also increase the expression of ACE2.	Glucose	192-199	angiotensin converting enzyme 2	Homo sapiens	88-92
34451782-7	2021	Indeed, among the investigated antcins, antcin-A, antcin-B, antcin-C, and antcin-I showed a pronounceable inhibition against ACE2.	CHEMBL1641967	60-68	angiotensin converting enzyme 2	Homo sapiens	125-129
34451782-7	2021	Indeed, among the investigated antcins, antcin-A, antcin-B, antcin-C, and antcin-I showed a pronounceable inhibition against ACE2.	antcin-i	74-82	angiotensin converting enzyme 2	Homo sapiens	125-129
34451782-8	2021	These findings suggest that antcins could be novel anti-ACE2 agents to prevent SARS-CoV-2 host cell entry and the following disease onset.	antcins	28-35	angiotensin converting enzyme 2	Homo sapiens	56-60
34490283-2	2021	Individuals with comorbidities associated with severe COVID-19 display higher levels of ACE2 in the lungs compared to those without comorbidities, and conditions such as cell stress, elevated glucose levels and hypoxia may also increase the expression of ACE2.	Glucose	192-199	angiotensin converting enzyme 2	Homo sapiens	255-259
34413267-7	2021	ACE2 expression level in the luminal subtype was positively correlated with CD8A and CD8B markers in CD8+ T cells, and CEACAM3, S100A12 in neutrophils.	Phenobarbital	29-36	angiotensin converting enzyme 2	Homo sapiens	0-4
34445700-12	2021	Vitamin D defends against SARS-CoV-2 through a complex mechanism through interactions between the modulation of innate and adaptive immune reactions, ACE2 expression, and inhibition of the renin-angiotensin system (RAS).	Vitamin D	0-9	angiotensin converting enzyme 2	Homo sapiens	150-154
34406302-4	2021	In such patients there is an overactivation of renin-angiotensin-aldosterone system, which promotes an increase in the expression of angiotensin-converting enzyme - 2 that acts as a receptor for the SPIKE protein expressed by the virus and enables the interaction between the host cell and Severe Acute Respiratory Syndrome Coronavirus 2.	Aldosterone	65-76	angiotensin converting enzyme 2	Homo sapiens	133-166
34415218-2	2021	In this study, we used combined molecular docking, molecular dynamics simulations and binding free energy analyses to investigate the potentials of vitamin D3 and its hydroxyderivatives as TMPRSS2 inhibitor and to inhibit the SARS-CoV-2 receptor binding domain (RBD) binding to angiotensin-converting enzyme 2 (ACE2), as well as to unveil molecular and structural basis of 1,25(OH)2D3 capability to inhibit ACE2 and SARS-CoV-2 RBD interactions.	Cholecalciferol	148-158	angiotensin converting enzyme 2	Homo sapiens	278-309
34415218-2	2021	In this study, we used combined molecular docking, molecular dynamics simulations and binding free energy analyses to investigate the potentials of vitamin D3 and its hydroxyderivatives as TMPRSS2 inhibitor and to inhibit the SARS-CoV-2 receptor binding domain (RBD) binding to angiotensin-converting enzyme 2 (ACE2), as well as to unveil molecular and structural basis of 1,25(OH)2D3 capability to inhibit ACE2 and SARS-CoV-2 RBD interactions.	Cholecalciferol	148-158	angiotensin converting enzyme 2	Homo sapiens	311-315
34415218-2	2021	In this study, we used combined molecular docking, molecular dynamics simulations and binding free energy analyses to investigate the potentials of vitamin D3 and its hydroxyderivatives as TMPRSS2 inhibitor and to inhibit the SARS-CoV-2 receptor binding domain (RBD) binding to angiotensin-converting enzyme 2 (ACE2), as well as to unveil molecular and structural basis of 1,25(OH)2D3 capability to inhibit ACE2 and SARS-CoV-2 RBD interactions.	Cholecalciferol	148-158	angiotensin converting enzyme 2	Homo sapiens	407-411
34415218-2	2021	In this study, we used combined molecular docking, molecular dynamics simulations and binding free energy analyses to investigate the potentials of vitamin D3 and its hydroxyderivatives as TMPRSS2 inhibitor and to inhibit the SARS-CoV-2 receptor binding domain (RBD) binding to angiotensin-converting enzyme 2 (ACE2), as well as to unveil molecular and structural basis of 1,25(OH)2D3 capability to inhibit ACE2 and SARS-CoV-2 RBD interactions.	Calcitriol	373-384	angiotensin converting enzyme 2	Homo sapiens	278-309
34415218-2	2021	In this study, we used combined molecular docking, molecular dynamics simulations and binding free energy analyses to investigate the potentials of vitamin D3 and its hydroxyderivatives as TMPRSS2 inhibitor and to inhibit the SARS-CoV-2 receptor binding domain (RBD) binding to angiotensin-converting enzyme 2 (ACE2), as well as to unveil molecular and structural basis of 1,25(OH)2D3 capability to inhibit ACE2 and SARS-CoV-2 RBD interactions.	Calcitriol	373-384	angiotensin converting enzyme 2	Homo sapiens	407-411
34415218-3	2021	The results show that vitamin D3 and its hydroxyderivatives are favorable to bind active site of TMPRSS2 and the binding site(s) between ACE2 and SARS-CoV2-RBD, which indicate that vitamin D3 and its biologically active hydroxyderivatives can serve as TMPRSS2 inhibitor and can inhibit ACE2 binding of SARS-CoV-2 RBD to prevent SARS-CoV-2 entry.	Cholecalciferol	22-32	angiotensin converting enzyme 2	Homo sapiens	137-141
34415218-3	2021	The results show that vitamin D3 and its hydroxyderivatives are favorable to bind active site of TMPRSS2 and the binding site(s) between ACE2 and SARS-CoV2-RBD, which indicate that vitamin D3 and its biologically active hydroxyderivatives can serve as TMPRSS2 inhibitor and can inhibit ACE2 binding of SARS-CoV-2 RBD to prevent SARS-CoV-2 entry.	Cholecalciferol	22-32	angiotensin converting enzyme 2	Homo sapiens	286-290
34415218-3	2021	The results show that vitamin D3 and its hydroxyderivatives are favorable to bind active site of TMPRSS2 and the binding site(s) between ACE2 and SARS-CoV2-RBD, which indicate that vitamin D3 and its biologically active hydroxyderivatives can serve as TMPRSS2 inhibitor and can inhibit ACE2 binding of SARS-CoV-2 RBD to prevent SARS-CoV-2 entry.	Cholecalciferol	181-191	angiotensin converting enzyme 2	Homo sapiens	137-141
34415218-3	2021	The results show that vitamin D3 and its hydroxyderivatives are favorable to bind active site of TMPRSS2 and the binding site(s) between ACE2 and SARS-CoV2-RBD, which indicate that vitamin D3 and its biologically active hydroxyderivatives can serve as TMPRSS2 inhibitor and can inhibit ACE2 binding of SARS-CoV-2 RBD to prevent SARS-CoV-2 entry.	Cholecalciferol	181-191	angiotensin converting enzyme 2	Homo sapiens	286-290
34440554-3	2021	METHODS: We have investigated the influence of the ACE inhibitors (lisinopril, captopril) and the AT1 antagonists (telmisartan, olmesartan) on the level of ACE2 mRNA and protein expression as well as their influence on the cytopathic effect of SARS-CoV-2 and on the cell barrier integrity in a Caco-2 cell model.	Lisinopril	67-77	angiotensin converting enzyme 2	Homo sapiens	156-160
34404805-4	2021	When administered therapeutically or prophylactically in the hACE2 mouse model, h11B11 alleviates and prevents SARS-CoV-2 replication and virus-induced pathological syndromes.	h11b11	80-86	angiotensin converting enzyme 2	Homo sapiens	61-66
34440554-3	2021	METHODS: We have investigated the influence of the ACE inhibitors (lisinopril, captopril) and the AT1 antagonists (telmisartan, olmesartan) on the level of ACE2 mRNA and protein expression as well as their influence on the cytopathic effect of SARS-CoV-2 and on the cell barrier integrity in a Caco-2 cell model.	Captopril	79-88	angiotensin converting enzyme 2	Homo sapiens	156-160
34445310-7	2021	Geraniin was found to effectively block the binding between the SARS-CoV-2 spike protein and hACE2 receptor in competitive enzyme-linked immunosorbent assay, suggesting that geraniin might inhibit the entry of SARS-CoV-2 into human epithelial cells.	Geraniin	0-8	angiotensin converting enzyme 2	Homo sapiens	93-98
34440554-3	2021	METHODS: We have investigated the influence of the ACE inhibitors (lisinopril, captopril) and the AT1 antagonists (telmisartan, olmesartan) on the level of ACE2 mRNA and protein expression as well as their influence on the cytopathic effect of SARS-CoV-2 and on the cell barrier integrity in a Caco-2 cell model.	Telmisartan	115-126	angiotensin converting enzyme 2	Homo sapiens	156-160
34445310-7	2021	Geraniin was found to effectively block the binding between the SARS-CoV-2 spike protein and hACE2 receptor in competitive enzyme-linked immunosorbent assay, suggesting that geraniin might inhibit the entry of SARS-CoV-2 into human epithelial cells.	Geraniin	174-182	angiotensin converting enzyme 2	Homo sapiens	93-98
34445310-8	2021	Geraniin also demonstrated a high affinity to both proteins despite a relatively lower equilibrium dissociation constant (KD) for the spike protein (0.63 muM) than hACE2 receptor (1.12 muM), according to biolayer interferometry-based analysis.	Geraniin	0-8	angiotensin converting enzyme 2	Homo sapiens	164-169
34440554-3	2021	METHODS: We have investigated the influence of the ACE inhibitors (lisinopril, captopril) and the AT1 antagonists (telmisartan, olmesartan) on the level of ACE2 mRNA and protein expression as well as their influence on the cytopathic effect of SARS-CoV-2 and on the cell barrier integrity in a Caco-2 cell model.	olmesartan	128-138	angiotensin converting enzyme 2	Homo sapiens	156-160
34421587-4	2021	Fenofibric acid also destabilized the receptor-binding domain (RBD) of the viral spike protein and inhibited RBD binding to ACE2 in enzyme-linked immunosorbent assay (ELISA) and whole cell-binding assays.	fenofibric acid	0-15	angiotensin converting enzyme 2	Homo sapiens	124-128
34256255-8	2021	Encouragingly, 6 drugs exhibited stable binding with RBD at the ACE2-RBD interface and 3 of them (gonadorelin, fondaparinux and atorvastatin) showed significantly enhanced binding after the MD simulations.	Fondaparinux	111-123	angiotensin converting enzyme 2	Homo sapiens	64-68
34353250-4	2022	Studies suggests SARS-CoV-2 entry via olfactory epithelium (OE) and the expression of type 2 transmembrane serine protease (TMPRSS2) in addition to angiotensin converting enzyme 2 (ACE2) can facilitate SARS-CoV-2 neurotropism.	Serine	107-113	angiotensin converting enzyme 2	Homo sapiens	181-185
34351542-5	2021	Two pentacyclic terpenoids (24-methylene cycloartenol and isoiguesteri) interacted with the hACE2 binding hotspots for the SARS-CoV-2 spike protein, while the abietane diterpenes were found accommodated within the S1-specificity pocket, interacting strongly with the active site residues TMPRSS2.	pentacyclic	4-15	angiotensin converting enzyme 2	Homo sapiens	92-97
34351542-5	2021	Two pentacyclic terpenoids (24-methylene cycloartenol and isoiguesteri) interacted with the hACE2 binding hotspots for the SARS-CoV-2 spike protein, while the abietane diterpenes were found accommodated within the S1-specificity pocket, interacting strongly with the active site residues TMPRSS2.	Terpenes	16-26	angiotensin converting enzyme 2	Homo sapiens	92-97
34351542-5	2021	Two pentacyclic terpenoids (24-methylene cycloartenol and isoiguesteri) interacted with the hACE2 binding hotspots for the SARS-CoV-2 spike protein, while the abietane diterpenes were found accommodated within the S1-specificity pocket, interacting strongly with the active site residues TMPRSS2.	24-methylenecycloartenol	28-53	angiotensin converting enzyme 2	Homo sapiens	92-97
34351542-5	2021	Two pentacyclic terpenoids (24-methylene cycloartenol and isoiguesteri) interacted with the hACE2 binding hotspots for the SARS-CoV-2 spike protein, while the abietane diterpenes were found accommodated within the S1-specificity pocket, interacting strongly with the active site residues TMPRSS2.	isoiguesteri	58-70	angiotensin converting enzyme 2	Homo sapiens	92-97
34157321-5	2021	Through bioinformatics analysis, we predicted nuclear export sequences in the ACE-2 protein and confirmed by in vitro testing that inhibition of XPO1 with selinexor induces nuclear localization of ACE-2.	selinexor	155-164	angiotensin converting enzyme 2	Homo sapiens	78-83
34157321-5	2021	Through bioinformatics analysis, we predicted nuclear export sequences in the ACE-2 protein and confirmed by in vitro testing that inhibition of XPO1 with selinexor induces nuclear localization of ACE-2.	selinexor	155-164	angiotensin converting enzyme 2	Homo sapiens	197-202
34373857-0	2021	Mesalamine Reduces Intestinal ACE2 Expression Without Modifying SARS-CoV-2 Infection or Disease Severity in Mice.	Mesalamine	0-10	angiotensin converting enzyme 2	Homo sapiens	30-34
34373857-13	2021	Expression of ACE2 was reduced following mesalamine treatment in enteroids, while CTSL expression was increased.	Mesalamine	41-51	angiotensin converting enzyme 2	Homo sapiens	14-18
34373857-18	2021	Mesalamine treatment reduced expression of the viral receptor ACE2 while concurrently increasing CTSL expression in human ileum organoids.	Mesalamine	0-10	angiotensin converting enzyme 2	Homo sapiens	62-66
34256255-8	2021	Encouragingly, 6 drugs exhibited stable binding with RBD at the ACE2-RBD interface and 3 of them (gonadorelin, fondaparinux and atorvastatin) showed significantly enhanced binding after the MD simulations.	Atorvastatin	128-140	angiotensin converting enzyme 2	Homo sapiens	64-68
34188005-9	2021	Results also revealed that spike protein binding to the ACE2 inhibited by MLN-4760 restored the enzymatic active conformation of the ACE2 from closed/inactive to open/active conformation by removing MLN-4760 binding from the ligand-binding pocket of ACE2.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	74-82	angiotensin converting enzyme 2	Homo sapiens	56-60
34188005-9	2021	Results also revealed that spike protein binding to the ACE2 inhibited by MLN-4760 restored the enzymatic active conformation of the ACE2 from closed/inactive to open/active conformation by removing MLN-4760 binding from the ligand-binding pocket of ACE2.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	74-82	angiotensin converting enzyme 2	Homo sapiens	133-137
34188005-8	2021	RESULTS: Our result showed that inhibition of ACE2 by MLN-4760 increased the affinity of the SARS-CoV-2 spike protein binding to ACE2.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	54-62	angiotensin converting enzyme 2	Homo sapiens	46-50
34188005-9	2021	Results also revealed that spike protein binding to the ACE2 inhibited by MLN-4760 restored the enzymatic active conformation of the ACE2 from closed/inactive to open/active conformation by removing MLN-4760 binding from the ligand-binding pocket of ACE2.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	74-82	angiotensin converting enzyme 2	Homo sapiens	250-254
34188005-8	2021	RESULTS: Our result showed that inhibition of ACE2 by MLN-4760 increased the affinity of the SARS-CoV-2 spike protein binding to ACE2.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	54-62	angiotensin converting enzyme 2	Homo sapiens	129-133
34188005-9	2021	Results also revealed that spike protein binding to the ACE2 inhibited by MLN-4760 restored the enzymatic active conformation of the ACE2 from closed/inactive to open/active conformation by removing MLN-4760 binding from the ligand-binding pocket of ACE2.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	199-207	angiotensin converting enzyme 2	Homo sapiens	56-60
34188005-9	2021	Results also revealed that spike protein binding to the ACE2 inhibited by MLN-4760 restored the enzymatic active conformation of the ACE2 from closed/inactive to open/active conformation by removing MLN-4760 binding from the ligand-binding pocket of ACE2.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	199-207	angiotensin converting enzyme 2	Homo sapiens	133-137
34188005-9	2021	Results also revealed that spike protein binding to the ACE2 inhibited by MLN-4760 restored the enzymatic active conformation of the ACE2 from closed/inactive to open/active conformation by removing MLN-4760 binding from the ligand-binding pocket of ACE2.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	199-207	angiotensin converting enzyme 2	Homo sapiens	250-254
34328726-0	2022	Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein.	Peptides	10-18	angiotensin converting enzyme 2	Homo sapiens	39-70
34441553-6	2021	Among these compounds, retusapurpurin A has shown high affinity to 3CLpro (DeltaG = -9.4 kcal/mol), RdRp (-7.5), RBD (-7.2), NSP13 (-9.4), and ACE2 (-10.4) and potent inhibition of viral entry by forming hydrogen bonds with amino acid residues within viral and human target proteins.	retusapurpurin A	23-39	angiotensin converting enzyme 2	Homo sapiens	143-147
34139598-3	2021	In the present paper it is proposed that SARS-CoV-2 patients suffer from depletion of tryptophan, as ACE2, a key element in the process of absorption of tryptophan from the food, is significantly reduced in the patients as coronavirus uses ACE2 as the receptor to enter the host cells.	Tryptophan	86-96	angiotensin converting enzyme 2	Homo sapiens	101-105
34139598-3	2021	In the present paper it is proposed that SARS-CoV-2 patients suffer from depletion of tryptophan, as ACE2, a key element in the process of absorption of tryptophan from the food, is significantly reduced in the patients as coronavirus uses ACE2 as the receptor to enter the host cells.	Tryptophan	86-96	angiotensin converting enzyme 2	Homo sapiens	240-244
34139598-3	2021	In the present paper it is proposed that SARS-CoV-2 patients suffer from depletion of tryptophan, as ACE2, a key element in the process of absorption of tryptophan from the food, is significantly reduced in the patients as coronavirus uses ACE2 as the receptor to enter the host cells.	Tryptophan	153-163	angiotensin converting enzyme 2	Homo sapiens	101-105
34111482-0	2021	A potential antiviral activity of Esculentoside A against binding interactions of SARS-COV-2 spike protein and angiotensin converting enzyme 2 (ACE2).	esculentoside A	34-49	angiotensin converting enzyme 2	Homo sapiens	111-142
34111482-0	2021	A potential antiviral activity of Esculentoside A against binding interactions of SARS-COV-2 spike protein and angiotensin converting enzyme 2 (ACE2).	esculentoside A	34-49	angiotensin converting enzyme 2	Homo sapiens	144-148
34328726-0	2022	Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein.	Peptides	10-18	angiotensin converting enzyme 2	Homo sapiens	72-77
34386518-9	2021	In addition, although the binding free energy at this point increased after the mutation of N354D, the conformation of the random coil (Pro384-Asp389) was looser than that of other systems, and the combined effect weakened the binding free energy between RBD and ACE2.	rbd	255-258	angiotensin converting enzyme 2	Homo sapiens	263-267
34189428-3	2021	Lung, intestine and kidney, major sites of viral infection, express ACE2 that harbours an intracellular, carboxy-terminal PDZ-recognition motif.	6-(4-chloro-2-fluoro-3-phenoxybenzyl)pyridazin-3(2H)-one	122-125	angiotensin converting enzyme 2	Homo sapiens	68-72
34312429-5	2021	By exploring the dynamics of three O-glycosylated models and the control systems of unglcosylated S4944 and S494D complexes, it was shown that the decoration of S494 with elongated O-glycans results in stabilized interactions on the direct RBD-ACE2.	o-glycans	181-190	angiotensin converting enzyme 2	Homo sapiens	244-248
34312429-6	2021	Calculation of the distances between RBD and two major H1, H2 helices of ACE2 and the interacting pairs of amino acids in the interface showed that the elongated O-glycan maintains these interactions by forming several polar contacts with the neighbouring residues while it would not interfere in the direct binding interface.	o-glycan	162-170	angiotensin converting enzyme 2	Homo sapiens	73-77
34312429-7	2021	Relative binding free energy of RBD-ACE2 is also more favorable in the O-glycosylated models with longer glycans.	Polysaccharides	105-112	angiotensin converting enzyme 2	Homo sapiens	36-40
34312429-8	2021	The increase of RBD binding affinity to ACE2 depends on the size of attached O-glycan.	o-glycan	77-85	angiotensin converting enzyme 2	Homo sapiens	40-44
34312429-9	2021	By increasing the size of O-glycan, the RBD-ACE2 binding affinity will increase.	o-glycan	26-34	angiotensin converting enzyme 2	Homo sapiens	44-48
34189428-10	2021	Conversely, elimination of the ACE2 C-terminal PDZ binding motif decreased ACE2 membrane residence and reduced pseudotyped virus entry.	6-(4-chloro-2-fluoro-3-phenoxybenzyl)pyridazin-3(2H)-one	47-50	angiotensin converting enzyme 2	Homo sapiens	31-35
34189428-10	2021	Conversely, elimination of the ACE2 C-terminal PDZ binding motif decreased ACE2 membrane residence and reduced pseudotyped virus entry.	6-(4-chloro-2-fluoro-3-phenoxybenzyl)pyridazin-3(2H)-one	47-50	angiotensin converting enzyme 2	Homo sapiens	75-79
34436248-5	2021	Inorganic polyphosphates (polyP) naturally found in marine bacteria and sponges have been shown to prevent viral entry, induce the innate immune response, and downregulate human ACE-2.	inorganic polyphosphates	0-24	angiotensin converting enzyme 2	Homo sapiens	178-183
34436248-5	2021	Inorganic polyphosphates (polyP) naturally found in marine bacteria and sponges have been shown to prevent viral entry, induce the innate immune response, and downregulate human ACE-2.	Polyphosphates	26-31	angiotensin converting enzyme 2	Homo sapiens	178-183
34436245-6	2021	The possible binding sites on both S-protein"s RBD and ACE2 were determined based on how they bind to heparin, which has been reported to exhibit significant antiviral activity against SARS CoV-2 through binding to RBD, preventing the virus from affecting ACE2.	Heparin	102-109	angiotensin converting enzyme 2	Homo sapiens	55-59
34337036-0	2021	Characterization of the Modulatory Effect of Hydroxychloroquine on ACE2 Activity: New Insights in relation to COVID-19.	Hydroxychloroquine	45-63	angiotensin converting enzyme 2	Homo sapiens	67-71
34337036-3	2021	Based on three-dimensional structural similarities between HCQ and the known ACE2 specific inhibitor MLN-4760, we compared their modulation on ACE2 activity.	Hydroxychloroquine	59-62	angiotensin converting enzyme 2	Homo sapiens	143-147
34337036-3	2021	Based on three-dimensional structural similarities between HCQ and the known ACE2 specific inhibitor MLN-4760, we compared their modulation on ACE2 activity.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	101-109	angiotensin converting enzyme 2	Homo sapiens	77-81
34337036-4	2021	Here we describe, for the first time, in a cell-free in vitro system that HCQ directly and dose-dependently inhibits the activity of recombinant human ACE2, with a potency similar to the MLN-4760.	Hydroxychloroquine	74-77	angiotensin converting enzyme 2	Homo sapiens	151-155
34337036-7	2021	In summary, here we demonstrate the direct inhibitory action of HCQ over the activity of the enzyme ACE2.	Hydroxychloroquine	64-67	angiotensin converting enzyme 2	Homo sapiens	100-104
34337036-8	2021	Then, by determining the activity of ACE2, we reveal that the interaction with the spike protein of SARS-CoV-2 leads to structural changes that at least partially displace the interaction of the said enzyme with HCQ.	Hydroxychloroquine	212-215	angiotensin converting enzyme 2	Homo sapiens	37-41
34214539-7	2021	In this study, molecular docking was employed to analyze the binding of two chemical compounds, SSAA09E2 and Nilotinib, with the druggable pocket of the ACE2-RBD complex.	N-((4-(4-methylpiperazin-1-yl)phenyl)methyl)-1,2-oxazole-5-carboxamide	96-104	angiotensin converting enzyme 2	Homo sapiens	153-157
34214539-7	2021	In this study, molecular docking was employed to analyze the binding of two chemical compounds, SSAA09E2 and Nilotinib, with the druggable pocket of the ACE2-RBD complex.	nilotinib	109-118	angiotensin converting enzyme 2	Homo sapiens	153-157
34214539-9	2021	Results show that both Nilotinib and SSAA09E2 can induce significant conformational changes in the ACE2-RBD complex, intervene with the hydrogen bonds, and influence the flexibility of proteins.	nilotinib	23-32	angiotensin converting enzyme 2	Homo sapiens	99-103
34214539-9	2021	Results show that both Nilotinib and SSAA09E2 can induce significant conformational changes in the ACE2-RBD complex, intervene with the hydrogen bonds, and influence the flexibility of proteins.	N-((4-(4-methylpiperazin-1-yl)phenyl)methyl)-1,2-oxazole-5-carboxamide	37-45	angiotensin converting enzyme 2	Homo sapiens	99-103
34436245-6	2021	The possible binding sites on both S-protein"s RBD and ACE2 were determined based on how they bind to heparin, which has been reported to exhibit significant antiviral activity against SARS CoV-2 through binding to RBD, preventing the virus from affecting ACE2.	Heparin	102-109	angiotensin converting enzyme 2	Homo sapiens	256-260
34436245-7	2021	Moreover, our modeling results illustrate that heparin can also bind to and block ACE2, acting as a competitor and protective agent against SARS CoV-2 infection.	Heparin	47-54	angiotensin converting enzyme 2	Homo sapiens	82-86
34196550-2	2021	The attachment of heparan sulfate (HS) to S-pro is necessary for its binding to ACE2.	Heparitin Sulfate	18-33	angiotensin converting enzyme 2	Homo sapiens	80-84
34356672-0	2021	Interference of Polydatin/Resveratrol in the ACE2:Spike Recognition during COVID-19 Infection.	polydatin	16-25	angiotensin converting enzyme 2	Homo sapiens	45-49
34356672-0	2021	Interference of Polydatin/Resveratrol in the ACE2:Spike Recognition during COVID-19 Infection.	Resveratrol	26-37	angiotensin converting enzyme 2	Homo sapiens	45-49
34306988-3	2021	Our in silico approach suggested that unique phytocompounds such as emodin, thymol and carvacrol, and artemisinin could physically bind SARS-CoV-2 spike glycoproteins (6VXX and 6VYB), SARS-CoV-2 B.1.351 South Africa variant of Spike glycoprotein (7NXA), and even with ACE2 and prevent the SARS-CoV-2 binding to the host ACE2, TMPRSS2 and neutrapilin-1 receptors.	Thymol	76-82	angiotensin converting enzyme 2	Homo sapiens	320-324
34306988-3	2021	Our in silico approach suggested that unique phytocompounds such as emodin, thymol and carvacrol, and artemisinin could physically bind SARS-CoV-2 spike glycoproteins (6VXX and 6VYB), SARS-CoV-2 B.1.351 South Africa variant of Spike glycoprotein (7NXA), and even with ACE2 and prevent the SARS-CoV-2 binding to the host ACE2, TMPRSS2 and neutrapilin-1 receptors.	carvacrol	87-96	angiotensin converting enzyme 2	Homo sapiens	320-324
34306988-3	2021	Our in silico approach suggested that unique phytocompounds such as emodin, thymol and carvacrol, and artemisinin could physically bind SARS-CoV-2 spike glycoproteins (6VXX and 6VYB), SARS-CoV-2 B.1.351 South Africa variant of Spike glycoprotein (7NXA), and even with ACE2 and prevent the SARS-CoV-2 binding to the host ACE2, TMPRSS2 and neutrapilin-1 receptors.	artemisinin	102-113	angiotensin converting enzyme 2	Homo sapiens	320-324
34306988-9	2021	Emodin showed best interactions with TMPRSS 2 and ACE2 with Etotal of -7.1 and -7.3 KJ mol-1 respectively, whereas artemisinin interacts with TMPRSS 2 and ACE2 with Etotal of -6.9 and -7.4 KJ mol-1 respectively.	Emodin	0-6	angiotensin converting enzyme 2	Homo sapiens	50-54
34306988-9	2021	Emodin showed best interactions with TMPRSS 2 and ACE2 with Etotal of -7.1 and -7.3 KJ mol-1 respectively, whereas artemisinin interacts with TMPRSS 2 and ACE2 with Etotal of -6.9 and -7.4 KJ mol-1 respectively.	artemisinin	115-126	angiotensin converting enzyme 2	Homo sapiens	155-159
34196550-2	2021	The attachment of heparan sulfate (HS) to S-pro is necessary for its binding to ACE2.	Heparitin Sulfate	35-37	angiotensin converting enzyme 2	Homo sapiens	80-84
34268505-4	2021	Studying the effect of temperature on the receptor-Spike interaction, we observed a significant and stepwise increase in RBD-ACE2 affinity at low temperatures, resulting in slower dissociation kinetics.	rbd	121-124	angiotensin converting enzyme 2	Homo sapiens	125-129
34282416-0	2021	Xeno-nucleic Acid (XNA) 2"-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding.	xeno-nucleic acid (xna) 2"-fluoro-arabino nucleic acid	0-54	angiotensin converting enzyme 2	Homo sapiens	132-136
34282416-0	2021	Xeno-nucleic Acid (XNA) 2"-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding.	fana	56-60	angiotensin converting enzyme 2	Homo sapiens	132-136
34345219-7	2021	Moreover, the intranasal administration of AYp28 could partially block pseudovirus invasion in hACE2 transgenic mice.	ayp28	43-48	angiotensin converting enzyme 2	Homo sapiens	95-100
34252168-5	2021	Endosomal acidification inhibitors like BafilomycinA1 and NH4Cl, which inhibit the CG pathway, reduce the uptake of RBD and impede Spike-pseudoviral infection in both AGS and AGS-ACE2 cells.	bafilomycin A1	40-53	angiotensin converting enzyme 2	Homo sapiens	179-183
34252168-5	2021	Endosomal acidification inhibitors like BafilomycinA1 and NH4Cl, which inhibit the CG pathway, reduce the uptake of RBD and impede Spike-pseudoviral infection in both AGS and AGS-ACE2 cells.	Ammonium Chloride	58-63	angiotensin converting enzyme 2	Homo sapiens	179-183
34243689-8	2021	Affinity of phytoconstituents towards SARS-CoV-2 spike protein-human ACE2 complex decreased as isomeldenin > tinosporaside > EGCG whereas in case of unbound ACE2, the strength of binding followed the order isomeldenin > tinosporaside > ellagic acid.	ISOMELDENIN	95-106	angiotensin converting enzyme 2	Homo sapiens	69-73
34356070-4	2021	It is known that angiotensin-converting enzyme 2 (ACE2), an important counter-regulatory component of the renin-angiotensin-aldosterone system (RAAS), is expressed in the airways.	Aldosterone	124-135	angiotensin converting enzyme 2	Homo sapiens	17-48
34356070-4	2021	It is known that angiotensin-converting enzyme 2 (ACE2), an important counter-regulatory component of the renin-angiotensin-aldosterone system (RAAS), is expressed in the airways.	Aldosterone	124-135	angiotensin converting enzyme 2	Homo sapiens	50-54
34243689-8	2021	Affinity of phytoconstituents towards SARS-CoV-2 spike protein-human ACE2 complex decreased as isomeldenin > tinosporaside > EGCG whereas in case of unbound ACE2, the strength of binding followed the order isomeldenin > tinosporaside > ellagic acid.	Tinosporaside	109-122	angiotensin converting enzyme 2	Homo sapiens	69-73
34243689-8	2021	Affinity of phytoconstituents towards SARS-CoV-2 spike protein-human ACE2 complex decreased as isomeldenin > tinosporaside > EGCG whereas in case of unbound ACE2, the strength of binding followed the order isomeldenin > tinosporaside > ellagic acid.	epigallocatechin gallate	125-129	angiotensin converting enzyme 2	Homo sapiens	69-73
34243689-8	2021	Affinity of phytoconstituents towards SARS-CoV-2 spike protein-human ACE2 complex decreased as isomeldenin > tinosporaside > EGCG whereas in case of unbound ACE2, the strength of binding followed the order isomeldenin > tinosporaside > ellagic acid.	ISOMELDENIN	206-217	angiotensin converting enzyme 2	Homo sapiens	69-73
34243689-8	2021	Affinity of phytoconstituents towards SARS-CoV-2 spike protein-human ACE2 complex decreased as isomeldenin > tinosporaside > EGCG whereas in case of unbound ACE2, the strength of binding followed the order isomeldenin > tinosporaside > ellagic acid.	Tinosporaside	220-233	angiotensin converting enzyme 2	Homo sapiens	69-73
34243689-8	2021	Affinity of phytoconstituents towards SARS-CoV-2 spike protein-human ACE2 complex decreased as isomeldenin > tinosporaside > EGCG whereas in case of unbound ACE2, the strength of binding followed the order isomeldenin > tinosporaside > ellagic acid.	Ellagic Acid	236-248	angiotensin converting enzyme 2	Homo sapiens	69-73
34236527-12	2021	Molecular docking of the system (S)-Linezolid RBD ACE2 and (R)-Linezolid RBD ACE2 was performed, the analysis was made using LigPlot+ and NCIplot software packages, to understand the intermolecular interactions.	(s)-linezolid	32-45	angiotensin converting enzyme 2	Homo sapiens	50-54
34110159-4	2021	We find that the hydrogen bond networks are rearranged in the variants and also that new hydrogen bonds are established between the RBD and ACE2 as a result of mutations.	Hydrogen	17-25	angiotensin converting enzyme 2	Homo sapiens	140-144
34236527-12	2021	Molecular docking of the system (S)-Linezolid RBD ACE2 and (R)-Linezolid RBD ACE2 was performed, the analysis was made using LigPlot+ and NCIplot software packages, to understand the intermolecular interactions.	(R)-Linezolid	59-72	angiotensin converting enzyme 2	Homo sapiens	77-81
34236527-13	2021	The UV-Vis and ECD of the complexes - (R and S)-Linezolid RBD ACE2 were performed in two layers with DFT/6-311++G(3df,2p) and DFT/6-31G(d), respectively.	(r and s)-linezolid	38-57	angiotensin converting enzyme 2	Homo sapiens	62-66
34236527-12	2021	Molecular docking of the system (S)-Linezolid RBD ACE2 and (R)-Linezolid RBD ACE2 was performed, the analysis was made using LigPlot+ and NCIplot software packages, to understand the intermolecular interactions.	(s)-linezolid	32-45	angiotensin converting enzyme 2	Homo sapiens	77-81
34229582-4	2021	Of these, three drugs showed significant therapeutic potential that warrant further investigation: SN35563, a ketamine ester analogue, was found to bind strongly to the ACE2 receptor but weakly within the spike receptor-binding domain (RBD); in contrast, arbidol and hydroxychloroquine bound preferentially with the spike RBD rather than ACE2.	sn35563	99-106	angiotensin converting enzyme 2	Homo sapiens	169-173
34110159-4	2021	We find that the hydrogen bond networks are rearranged in the variants and also that new hydrogen bonds are established between the RBD and ACE2 as a result of mutations.	Hydrogen	89-97	angiotensin converting enzyme 2	Homo sapiens	140-144
34229582-5	2021	A fourth drug, remdesivir, bound approximately equally to both the ACE2 and viral spike RBD, thus potentially increasing risk of viral infection by bringing the spike protein into closer proximity to the ACE2 receptor.	remdesivir	15-25	angiotensin converting enzyme 2	Homo sapiens	67-71
34225565-13	2021	Interestingly, Leu455 hotspot residue in the S protein, also predicted to participate in binding with ACE2, was engaged by WND and WFA.	1-[2-({3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propyl}amino)phenyl]piperidine-4-carboxylic acid	131-134	angiotensin converting enzyme 2	Homo sapiens	102-106
34229582-6	2021	We suggest more experimental investigations to test that SN35563-in combination with arbidol or hydroxychloroquine-might act synergistically to block viral cell entry by providing therapeutic blockade of the host ACE2 simultaneous with reduction of viral spike receptor-binding; and that this combination therapy would allow the use of smaller doses of each drug.Communicated by Ramaswamy H. Sarma.	sn35563	57-64	angiotensin converting enzyme 2	Homo sapiens	213-217
34225565-14	2021	HighlightsPlants" natural active compounds may aid in the development of COVID-19 therapeutics.MD simulation study revealed stable binding of withanolide D and withaferin A with spike proteinWithanolide D and withaferin A could be effective against SARS-CoV-2 spike protein.Discovery of druggable agents that have less or lack of binding affinity with ACE2 to avoid the organs associated with comorbidities.According to ADMET selected phytochemicals may be used as druggable compounds.Communicated by Ramaswamy H. Sarma.	withaferin A	160-172	angiotensin converting enzyme 2	Homo sapiens	352-356
34230209-5	2021	ELISA and limited proteolysis assays using nano- LC-MS/MS mapped polyP120 binding to ACE2, and site-directed mutagenesis confirmed interactions between ACE2 and SARS-CoV-2 RdRp and identified the specific amino acid residues involved.	polyp120	65-73	angiotensin converting enzyme 2	Homo sapiens	85-89
34230209-6	2021	PolyP120 enhanced the proteasomal degradation of both ACE2 and RdRp, thus impairing replication of the British B.1.1.7 SARS-CoV-2 variant.	polyp120	0-8	angiotensin converting enzyme 2	Homo sapiens	54-58
34281182-9	2021	Furthermore, PA may modulate the expression of ACE2, the main cell surface receptor for the SARS-CoV-2 spike protein.	Palmitic Acid	13-15	angiotensin converting enzyme 2	Homo sapiens	47-51
34291081-8	2021	Amongst, the binding affinity for beta-sitosterol and beta-elemene against S-ACE2 showed -12.0 and -10.9 kcal/mol, respectively.	gamma-sitosterol	34-49	angiotensin converting enzyme 2	Homo sapiens	77-81
34291081-8	2021	Amongst, the binding affinity for beta-sitosterol and beta-elemene against S-ACE2 showed -12.0 and -10.9 kcal/mol, respectively.	beta-elemene	54-66	angiotensin converting enzyme 2	Homo sapiens	77-81
34096226-1	2021	Angiotensin-converting enzyme II (ACE2) in association with type II transmembrane serine protease (TMPRSS2) is considered the main receptor of SARS-CoV-2.	Serine	82-88	angiotensin converting enzyme 2	Homo sapiens	34-38
34132301-3	2021	However, the underlying mechanism of how the spike receptor binding domain (RBD) of SARS-CoV-2 cooperates with human ACE2 (hACE2), cat ACE2 (cACE2) and dog ACE2 (dACE2) and the variation in binding remains largely unsolved.	cace2	141-146	angiotensin converting enzyme 2	Homo sapiens	135-139
34183368-5	2021	Our proximity-based luciferase assay takes advantage of the fact that the most potent SARS-CoV-2 nAbs function by blocking the binding between SARS-CoV-2 and angiotensin-converting enzyme 2.	nabs	97-101	angiotensin converting enzyme 2	Homo sapiens	158-189
34188154-5	2021	We validated ACE2 protein expression and localization in formalin-fixed, paraffin-embedded matched colon and ileal tissues using immunohistochemistry.	Paraffin	73-81	angiotensin converting enzyme 2	Homo sapiens	13-17
34203261-0	2021	Imatinib (STI571) Inhibits the Expression of Angiotensin-Converting Enzyme 2 and Cell Entry of the SARS-CoV-2-Derived Pseudotyped Viral Particles.	Imatinib Mesylate	0-8	angiotensin converting enzyme 2	Homo sapiens	45-76
34203261-0	2021	Imatinib (STI571) Inhibits the Expression of Angiotensin-Converting Enzyme 2 and Cell Entry of the SARS-CoV-2-Derived Pseudotyped Viral Particles.	Imatinib Mesylate	10-16	angiotensin converting enzyme 2	Homo sapiens	45-76
34203261-2	2021	Here, we show that the receptor tyrosine kinase inhibitor imatinib (also known as STI571, Gleevec) can inhibit the expression of the endogenous ACE2 gene at both the transcript and protein levels.	Imatinib Mesylate	58-66	angiotensin converting enzyme 2	Homo sapiens	144-148
34137759-7	2021	We also found that the lower binding affinity of RaTG13 to ACE2 is mainly due to a mutated residue (D501) which resulted in a less favorable complex formation for binding.	d501	100-104	angiotensin converting enzyme 2	Homo sapiens	59-63
34185793-0	2021	Alteration of L-Dopa decarboxylase expression in SARS-CoV-2 infection and its association with the interferon-inducible ACE2 isoform.	Levodopa	14-20	angiotensin converting enzyme 2	Homo sapiens	120-124
34185793-1	2021	L-Dopa decarboxylase (DDC) is the most significantly co-expressed gene with ACE2, which encodes for the SARS-CoV-2 receptor angiotensin-converting enzyme 2 and the interferon-inducible truncated isoform dACE2.	Levodopa	0-6	angiotensin converting enzyme 2	Homo sapiens	124-155
34132301-6	2021	Furthermore, alanine scanning analysis results validated some key residues of the spike RBD interact with ACE2 and provided clues to the variation of amino acid that could influence the transmissibility or immune responses of SARS-CoV-2.	Alanine	13-20	angiotensin converting enzyme 2	Homo sapiens	106-110
34169390-0	2021	Molecular screening of glycyrrhizin-based inhibitors against ACE2 host receptor of SARS-CoV-2.	Glycyrrhizic Acid	23-35	angiotensin converting enzyme 2	Homo sapiens	61-65
34169390-6	2021	Three compounds, deslanoside, digitoxin, and digoxin, were reported to show strong binding with ACE2.	Deslanoside	17-28	angiotensin converting enzyme 2	Homo sapiens	96-100
34169390-6	2021	Three compounds, deslanoside, digitoxin, and digoxin, were reported to show strong binding with ACE2.	Digitoxin	30-39	angiotensin converting enzyme 2	Homo sapiens	96-100
34169390-6	2021	Three compounds, deslanoside, digitoxin, and digoxin, were reported to show strong binding with ACE2.	Digoxin	45-52	angiotensin converting enzyme 2	Homo sapiens	96-100
34201505-2	2021	Following the binding between S1 subunit and ACE2 receptor, different serine proteases, including TMPRSS2 and furin, trigger and participate in the fusion of the viral envelope with the host cell membrane.	Serine	70-76	angiotensin converting enzyme 2	Homo sapiens	45-49
34168168-4	2021	Spike protein exhibited the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2.	Hydrogen	118-126	angiotensin converting enzyme 2	Homo sapiens	56-60
34168168-4	2021	Spike protein exhibited the highest binding to human (h)ACE2 of all the species tested, forming the highest number of hydrogen bonds with hACE2.	Hydrogen	118-126	angiotensin converting enzyme 2	Homo sapiens	138-143
34155214-5	2021	Additional disulfide mutations caused the fixing of a closed ACE2 conformation to avoid off-target effects of protease activity, and also improved structural stability.	Disulfides	11-20	angiotensin converting enzyme 2	Homo sapiens	61-65
34206648-2	2021	Human umbilical vein and aortic endothelial cells, pre-treated with prolyl carboxypeptidase-inhibitor compound 8o and/or angiotensin converting enzyme 2 (ACE2)-inhibitor DX600, were incubated with (pyr)-apelin-13 for different time periods.	dx600	170-175	angiotensin converting enzyme 2	Homo sapiens	154-158
34195577-1	2021	Background: The SARS-CoV-2 virus enters cells via Angiotensin-converting enzyme 2 (ACE2), disrupting the renin-angiotensin-aldosterone axis, potentially contributing to lung injury.	Aldosterone	123-134	angiotensin converting enzyme 2	Homo sapiens	50-81
34204256-2	2021	In this study, the binding energy of these carotenoids with the SARS-CoV-2 Spike-glycoprotein was predicted by molecular docking simulation, and their inhibitory activity was confirmed with SARS-CoV-2 pseudovirus on HEK293 cells overexpressing angiotensin-converting enzyme 2 (ACE2).	Carotenoids	43-54	angiotensin converting enzyme 2	Homo sapiens	244-275
34204256-2	2021	In this study, the binding energy of these carotenoids with the SARS-CoV-2 Spike-glycoprotein was predicted by molecular docking simulation, and their inhibitory activity was confirmed with SARS-CoV-2 pseudovirus on HEK293 cells overexpressing angiotensin-converting enzyme 2 (ACE2).	Carotenoids	43-54	angiotensin converting enzyme 2	Homo sapiens	277-281
34195577-1	2021	Background: The SARS-CoV-2 virus enters cells via Angiotensin-converting enzyme 2 (ACE2), disrupting the renin-angiotensin-aldosterone axis, potentially contributing to lung injury.	Aldosterone	123-134	angiotensin converting enzyme 2	Homo sapiens	83-87
34177593-2	2021	SARS-CoV-2 uses as a receptor angiotensin-converting enzyme 2 (ACE-2), a critical member of the renin-angiotensin-aldosterone system (RAAS) involved in the regulation of blood pressure and fluid system.	Aldosterone	114-125	angiotensin converting enzyme 2	Homo sapiens	30-61
34150335-3	2021	While groups such as disulfides in ACE2"s zinc metallopeptidase, and also in COVID-19"s spikes, facilitate such binding, it is worth exploring how similar complementary sites on materials such as polymers, metals, ceramics, fabrics, and biomaterials promote binding of viruses and bacteria and how they could be further engineered to prevent bioactivity, or to act as agents to collect viral payloads in filters or similar devices.	Disulfides	21-31	angiotensin converting enzyme 2	Homo sapiens	35-39
34140611-5	2021	We found that the lipid mediators, elovanoid (ELV)-N32 or Resolvin D6-isomer (RvD6i) decreased the expression of the ACE2 receptor, furin, and integrins in damaged corneas or IFNgamma-stimulated HCEC.	elovanoid	35-44	angiotensin converting enzyme 2	Homo sapiens	117-121
34140611-5	2021	We found that the lipid mediators, elovanoid (ELV)-N32 or Resolvin D6-isomer (RvD6i) decreased the expression of the ACE2 receptor, furin, and integrins in damaged corneas or IFNgamma-stimulated HCEC.	elv)-n32	46-54	angiotensin converting enzyme 2	Homo sapiens	117-121
34140611-5	2021	We found that the lipid mediators, elovanoid (ELV)-N32 or Resolvin D6-isomer (RvD6i) decreased the expression of the ACE2 receptor, furin, and integrins in damaged corneas or IFNgamma-stimulated HCEC.	oxynide	67-69	angiotensin converting enzyme 2	Homo sapiens	117-121
34177593-2	2021	SARS-CoV-2 uses as a receptor angiotensin-converting enzyme 2 (ACE-2), a critical member of the renin-angiotensin-aldosterone system (RAAS) involved in the regulation of blood pressure and fluid system.	Aldosterone	114-125	angiotensin converting enzyme 2	Homo sapiens	63-68
34178985-5	2021	Methods: We measured the protein expression of ACE2 in the gastrointestinal tract using immunohistochemical (IHC) staining with an ACE2-specific antibody of paraffin-embedded colon, stomach, liver, and pancreatic tissues.	Paraffin	157-165	angiotensin converting enzyme 2	Homo sapiens	47-51
34179075-2	2021	Cellular heparan sulfate (HS) has been found to bind SARS-CoV-2 spike protein (SV2-S) and co-operate with cell surface receptor angiotensin-converting enzyme 2 (ACE2) to mediate SARS-CoV-2 infection of host cells.	Heparitin Sulfate	9-24	angiotensin converting enzyme 2	Homo sapiens	128-159
34208050-5	2021	EGCG, TSA, and TFDG significantly inhibited interaction between recombinant ACE2 and RBD of S protein.	epigallocatechin gallate	0-4	angiotensin converting enzyme 2	Homo sapiens	76-80
34179075-2	2021	Cellular heparan sulfate (HS) has been found to bind SARS-CoV-2 spike protein (SV2-S) and co-operate with cell surface receptor angiotensin-converting enzyme 2 (ACE2) to mediate SARS-CoV-2 infection of host cells.	Heparitin Sulfate	9-24	angiotensin converting enzyme 2	Homo sapiens	161-165
34112764-0	2021	Correction To: Ceftazidime is a potential drug to inhibit SARS-CoV-2 infection in vitro by blocking spike protein-ACE2 interaction.	Ceftazidime	15-26	angiotensin converting enzyme 2	Homo sapiens	114-118
34127969-8	2021	In a lethal humanized hACE2 mouse model of SARS-CoV-2, FXa prolonged survival while combination with rivaroxaban but not fondaparinux abrogated this protection.	Rivaroxaban	101-112	angiotensin converting enzyme 2	Homo sapiens	22-27
34178985-5	2021	Methods: We measured the protein expression of ACE2 in the gastrointestinal tract using immunohistochemical (IHC) staining with an ACE2-specific antibody of paraffin-embedded colon, stomach, liver, and pancreatic tissues.	Paraffin	157-165	angiotensin converting enzyme 2	Homo sapiens	131-135
34112217-8	2021	CONCLUSION: These clinical and experimental data indicate that methotrexate has certain protective effects on SARS-CoV-2 infection via downregulating ACE2.	Methotrexate	63-75	angiotensin converting enzyme 2	Homo sapiens	150-154
34105049-12	2022	The molecular docking results indicated that isovitexin and procyanidin B1 showed the highest affinity with 3CL and ACE2, respectively, which were confirmed by MD simulation.	isovitexin	45-55	angiotensin converting enzyme 2	Homo sapiens	116-120
34105049-12	2022	The molecular docking results indicated that isovitexin and procyanidin B1 showed the highest affinity with 3CL and ACE2, respectively, which were confirmed by MD simulation.	procyanidin B1	60-74	angiotensin converting enzyme 2	Homo sapiens	116-120
34106944-4	2021	Moreover, we have compared NhPV with another compound, Suramin, for their anti-SARS-CoV-2 activities and the mode of their actions, and found that both NhPV and Suramin are able to directly interrupt SCoV-2-SP binding to its receptor ACE2 and block the viral entry step.	Suramin	161-168	angiotensin converting enzyme 2	Homo sapiens	234-238
34208050-5	2021	EGCG, TSA, and TFDG significantly inhibited interaction between recombinant ACE2 and RBD of S protein.	theasinensin A	6-9	angiotensin converting enzyme 2	Homo sapiens	76-80
34208050-5	2021	EGCG, TSA, and TFDG significantly inhibited interaction between recombinant ACE2 and RBD of S protein.	tfdg	15-19	angiotensin converting enzyme 2	Homo sapiens	76-80
34208136-2	2021	SARS-CoV-2 infection occurs through the interaction of the viral protein Spike with the angiotensin II receptor (ACE 2), leading to an increase of angiotensin II and activation of nicotinamide adenine dinucleotide phosphate oxidase2 (NOX2), resulting in the release of both reactive oxygen species (ROS) and inflammatory molecules.	NAD	180-213	angiotensin converting enzyme 2	Homo sapiens	113-118
34200372-0	2021	ACE2-Independent Interaction of SARS-CoV-2 Spike Protein with Human Epithelial Cells Is Inhibited by Unfractionated Heparin.	Heparin	116-123	angiotensin converting enzyme 2	Homo sapiens	0-4
34208136-2	2021	SARS-CoV-2 infection occurs through the interaction of the viral protein Spike with the angiotensin II receptor (ACE 2), leading to an increase of angiotensin II and activation of nicotinamide adenine dinucleotide phosphate oxidase2 (NOX2), resulting in the release of both reactive oxygen species (ROS) and inflammatory molecules.	Reactive Oxygen Species	274-297	angiotensin converting enzyme 2	Homo sapiens	113-118
34208136-2	2021	SARS-CoV-2 infection occurs through the interaction of the viral protein Spike with the angiotensin II receptor (ACE 2), leading to an increase of angiotensin II and activation of nicotinamide adenine dinucleotide phosphate oxidase2 (NOX2), resulting in the release of both reactive oxygen species (ROS) and inflammatory molecules.	Reactive Oxygen Species	299-302	angiotensin converting enzyme 2	Homo sapiens	113-118
34077350-10	2021	SARS-CoV-2 primarily targets ACE-2 receptors because this virus receives this receptor as a host for the cellular entry of the virus in the body, these shows down regulations in the maintenance of BP, and the body suffers from multi-organ failure.	DDP-BLM protocol	197-199	angiotensin converting enzyme 2	Homo sapiens	29-34
34198852-4	2021	ACE2 receptor downregulation occurred specifically in females in Th2 high asthma, while proteases broadly assisting coronavirus and influenza viral entry, TMPRSS2, and TMPRSS4, were highly upregulated in both sexes.	th2	65-68	angiotensin converting enzyme 2	Homo sapiens	0-4
34130375-3	2021	Thus, in this current computational study we carried out molecular docking experiments to assess the bridging potentials of some commercial drugs such as chloroquine, hydroxychloroquine, lopinavir, ritonavir, nafamostat, camostat, famotidine, umifenovir, nitazoxanide, ivermectin, and fluvoxamine at the interface between human ACE2 and the coronavirus spike glycoprotein complex.	Chloroquine	154-165	angiotensin converting enzyme 2	Homo sapiens	328-332
34130375-3	2021	Thus, in this current computational study we carried out molecular docking experiments to assess the bridging potentials of some commercial drugs such as chloroquine, hydroxychloroquine, lopinavir, ritonavir, nafamostat, camostat, famotidine, umifenovir, nitazoxanide, ivermectin, and fluvoxamine at the interface between human ACE2 and the coronavirus spike glycoprotein complex.	nitazoxanide	255-267	angiotensin converting enzyme 2	Homo sapiens	328-332
34160563-0	2021	ACE2 Expression Is Upregulated in Inflammatory Corneal Epithelial Cells and Attenuated by Resveratrol.	Resveratrol	90-101	angiotensin converting enzyme 2	Homo sapiens	0-4
34130375-3	2021	Thus, in this current computational study we carried out molecular docking experiments to assess the bridging potentials of some commercial drugs such as chloroquine, hydroxychloroquine, lopinavir, ritonavir, nafamostat, camostat, famotidine, umifenovir, nitazoxanide, ivermectin, and fluvoxamine at the interface between human ACE2 and the coronavirus spike glycoprotein complex.	Ivermectin	269-279	angiotensin converting enzyme 2	Homo sapiens	328-332
34130375-3	2021	Thus, in this current computational study we carried out molecular docking experiments to assess the bridging potentials of some commercial drugs such as chloroquine, hydroxychloroquine, lopinavir, ritonavir, nafamostat, camostat, famotidine, umifenovir, nitazoxanide, ivermectin, and fluvoxamine at the interface between human ACE2 and the coronavirus spike glycoprotein complex.	Fluvoxamine	285-296	angiotensin converting enzyme 2	Homo sapiens	328-332
34130375-9	2021	The best hit compounds on the human ACE2 were the lopinavir (-10.1 kcal/mol), ritonavir (-8.9 kcal/mol), and nafamostat (-8.7 kcal/mol).	Lopinavir	50-59	angiotensin converting enzyme 2	Homo sapiens	36-40
34130375-9	2021	The best hit compounds on the human ACE2 were the lopinavir (-10.1 kcal/mol), ritonavir (-8.9 kcal/mol), and nafamostat (-8.7 kcal/mol).	Ritonavir	78-87	angiotensin converting enzyme 2	Homo sapiens	36-40
34130375-9	2021	The best hit compounds on the human ACE2 were the lopinavir (-10.1 kcal/mol), ritonavir (-8.9 kcal/mol), and nafamostat (-8.7 kcal/mol).	nafamostat	109-119	angiotensin converting enzyme 2	Homo sapiens	36-40
34130375-11	2021	Nafamostat showed a dual bridging potential against ACE2 and spike glycoprotein, and could therefore be a promising lead compound in the prevention and control of this disease.	nafamostat	0-10	angiotensin converting enzyme 2	Homo sapiens	52-56
34130375-3	2021	Thus, in this current computational study we carried out molecular docking experiments to assess the bridging potentials of some commercial drugs such as chloroquine, hydroxychloroquine, lopinavir, ritonavir, nafamostat, camostat, famotidine, umifenovir, nitazoxanide, ivermectin, and fluvoxamine at the interface between human ACE2 and the coronavirus spike glycoprotein complex.	Hydroxychloroquine	167-185	angiotensin converting enzyme 2	Homo sapiens	328-332
34130375-3	2021	Thus, in this current computational study we carried out molecular docking experiments to assess the bridging potentials of some commercial drugs such as chloroquine, hydroxychloroquine, lopinavir, ritonavir, nafamostat, camostat, famotidine, umifenovir, nitazoxanide, ivermectin, and fluvoxamine at the interface between human ACE2 and the coronavirus spike glycoprotein complex.	Lopinavir	187-196	angiotensin converting enzyme 2	Homo sapiens	328-332
34130375-3	2021	Thus, in this current computational study we carried out molecular docking experiments to assess the bridging potentials of some commercial drugs such as chloroquine, hydroxychloroquine, lopinavir, ritonavir, nafamostat, camostat, famotidine, umifenovir, nitazoxanide, ivermectin, and fluvoxamine at the interface between human ACE2 and the coronavirus spike glycoprotein complex.	Ritonavir	198-207	angiotensin converting enzyme 2	Homo sapiens	328-332
34130375-3	2021	Thus, in this current computational study we carried out molecular docking experiments to assess the bridging potentials of some commercial drugs such as chloroquine, hydroxychloroquine, lopinavir, ritonavir, nafamostat, camostat, famotidine, umifenovir, nitazoxanide, ivermectin, and fluvoxamine at the interface between human ACE2 and the coronavirus spike glycoprotein complex.	nafamostat	209-219	angiotensin converting enzyme 2	Homo sapiens	328-332
34130375-3	2021	Thus, in this current computational study we carried out molecular docking experiments to assess the bridging potentials of some commercial drugs such as chloroquine, hydroxychloroquine, lopinavir, ritonavir, nafamostat, camostat, famotidine, umifenovir, nitazoxanide, ivermectin, and fluvoxamine at the interface between human ACE2 and the coronavirus spike glycoprotein complex.	camostat	221-229	angiotensin converting enzyme 2	Homo sapiens	328-332
34130375-3	2021	Thus, in this current computational study we carried out molecular docking experiments to assess the bridging potentials of some commercial drugs such as chloroquine, hydroxychloroquine, lopinavir, ritonavir, nafamostat, camostat, famotidine, umifenovir, nitazoxanide, ivermectin, and fluvoxamine at the interface between human ACE2 and the coronavirus spike glycoprotein complex.	Famotidine	231-241	angiotensin converting enzyme 2	Homo sapiens	328-332
34130375-3	2021	Thus, in this current computational study we carried out molecular docking experiments to assess the bridging potentials of some commercial drugs such as chloroquine, hydroxychloroquine, lopinavir, ritonavir, nafamostat, camostat, famotidine, umifenovir, nitazoxanide, ivermectin, and fluvoxamine at the interface between human ACE2 and the coronavirus spike glycoprotein complex.	umifenovir	243-253	angiotensin converting enzyme 2	Homo sapiens	328-332
34072087-4	2021	Here, we describe the development of an in vitro RBD-ACE2 binding assay and its application to identify inhibitors of the interaction of the SARS-CoV-2 RBD to ACE2 by the high-throughput screening of two compound libraries (LOPAC 1280 and DiscoveryProbeTM).	discoveryprobetm	239-255	angiotensin converting enzyme 2	Homo sapiens	53-57
34122058-6	2021	SARS-CoV-2 recognizes O-acetylated neuraminic acids and also several membrane proteins, such as ACE2, as the result of evolutionary switches of O-Ac SA recognition specificities.	Neuraminic Acids	35-51	angiotensin converting enzyme 2	Homo sapiens	96-100
34072087-4	2021	Here, we describe the development of an in vitro RBD-ACE2 binding assay and its application to identify inhibitors of the interaction of the SARS-CoV-2 RBD to ACE2 by the high-throughput screening of two compound libraries (LOPAC 1280 and DiscoveryProbeTM).	discoveryprobetm	239-255	angiotensin converting enzyme 2	Homo sapiens	159-163
34122058-6	2021	SARS-CoV-2 recognizes O-acetylated neuraminic acids and also several membrane proteins, such as ACE2, as the result of evolutionary switches of O-Ac SA recognition specificities.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	149-151	angiotensin converting enzyme 2	Homo sapiens	96-100
34067878-0	2021	Exploring the Role of Glycans in the Interaction of SARS-CoV-2 RBD and Human Receptor ACE2.	Polysaccharides	22-29	angiotensin converting enzyme 2	Homo sapiens	86-90
34067683-4	2021	However, ACE2 could be shed from the surface to be soluble ACE2 (sACE2) in the circulation.	sace2	65-70	angiotensin converting enzyme 2	Homo sapiens	9-13
34067683-4	2021	However, ACE2 could be shed from the surface to be soluble ACE2 (sACE2) in the circulation.	sace2	65-70	angiotensin converting enzyme 2	Homo sapiens	59-63
34067878-10	2021	Furthermore, our simulations reveal how the glycan on Asn90 of ACE2 can play a distinct role in the binding and unbinding of RBD.	Polysaccharides	44-50	angiotensin converting enzyme 2	Homo sapiens	63-67
34847569-2	2021	Enterocyte ACE2 is coexpressed as the apical membrane trafficking partner obligatory for expression and activity of the B0AT1 sodium-dependent neutral amino acid transporter.	Sodium	126-132	angiotensin converting enzyme 2	Homo sapiens	11-15
34065735-10	2021	Vitamin D increases the bioavailability and expression of ACE2, which may be responsible for trapping and inactivating the virus.	Vitamin D	0-9	angiotensin converting enzyme 2	Homo sapiens	58-62
34068579-0	2021	In Silico Studies of Some Isoflavonoids as Potential Candidates against COVID-19 Targeting Human ACE2 (hACE2) and Viral Main Protease (Mpro).	isoflavonoids	26-39	angiotensin converting enzyme 2	Homo sapiens	97-101
34068579-0	2021	In Silico Studies of Some Isoflavonoids as Potential Candidates against COVID-19 Targeting Human ACE2 (hACE2) and Viral Main Protease (Mpro).	isoflavonoids	26-39	angiotensin converting enzyme 2	Homo sapiens	103-108
34065735-13	2021	In conclusion, vitamin D defends the body against SARS-CoV-2 through a novel complex mechanism that operates through interactions between the activation of both innate and adaptive immunity, ACE2 expression, and inhibition of the RAS system.	Vitamin D	15-24	angiotensin converting enzyme 2	Homo sapiens	191-195
34816207-4	2021	17beta-oestradiol increases expression level and activity of angiotensin converting enzyme-2 (ACE2) and the alternative signaling pathway of Ang II via the angiotensin II receptor type II (AT2R) and the Mas receptor is more dominant in female sex than in male sex.	Estradiol	0-17	angiotensin converting enzyme 2	Homo sapiens	61-92
34816207-4	2021	17beta-oestradiol increases expression level and activity of angiotensin converting enzyme-2 (ACE2) and the alternative signaling pathway of Ang II via the angiotensin II receptor type II (AT2R) and the Mas receptor is more dominant in female sex than in male sex.	Estradiol	0-17	angiotensin converting enzyme 2	Homo sapiens	94-98
34064568-8	2021	Resveratrol was shown to mitigate the major pathways involved in the pathogenesis of SARS-CoV-2 including regulation of the renin-angiotensin system and expression of angiotensin-converting enzyme 2, stimulation of immune system and downregulation of pro-inflammatory cytokine release.	Resveratrol	0-11	angiotensin converting enzyme 2	Homo sapiens	167-198
34068579-4	2021	In this work, molecular docking studies were carried out to investigate the interaction of fifty-nine isoflavonoids against hACE2 and viral Mpro.	isoflavonoids	102-115	angiotensin converting enzyme 2	Homo sapiens	124-129
34068579-6	2021	The results revealed that the examined isoflavonoids bound perfectly the hACE-2 with free binding energies ranging from -24.02 to -39.33 kcal mol-1, compared to the co-crystallized ligand (-21.39 kcal mol-1).	isoflavonoids	39-52	angiotensin converting enzyme 2	Homo sapiens	73-79
34230886-12	2021	Firstly, through the downregulation of angiotensin-converting enzyme 2 receptors, resulting in the imbalance of dopamine and norepinephrine; and secondly, the virus could cause cellular vacuolation, demyelination and gliosis, leading to encephalitis and associated movement disorders.	Dopamine	112-120	angiotensin converting enzyme 2	Homo sapiens	39-70
34142531-2	2021	Based on the structure of the complex of the protein S receptor-binding domain (RBD) and ACE2, the design of chimeric molecules consisting of two 22-23-mer peptides linked to each other by disulfide bonds was carried out.	Disulfides	189-198	angiotensin converting enzyme 2	Homo sapiens	89-93
34083848-5	2021	ACE2 is a mono-carboxypeptidase best known for cleaving major peptides and substrates.	Peptides	62-70	angiotensin converting enzyme 2	Homo sapiens	0-4
34183961-7	2021	Results: Saikosaponin A (e.g. in Bupleurum chinense), Baicalin (e.g. in several species in the genus Scutellaria), Glycyrrhizin (Glycyrrhiza glabra), MLN-4760 and Umifenovir better occupied ACE2 to inhibit viral RBD binding and are suggested as the top five inhibitors of the SARS-CoV-2 binding site of ACE2.	saikosaponin D	9-23	angiotensin converting enzyme 2	Homo sapiens	190-194
34183961-7	2021	Results: Saikosaponin A (e.g. in Bupleurum chinense), Baicalin (e.g. in several species in the genus Scutellaria), Glycyrrhizin (Glycyrrhiza glabra), MLN-4760 and Umifenovir better occupied ACE2 to inhibit viral RBD binding and are suggested as the top five inhibitors of the SARS-CoV-2 binding site of ACE2.	saikosaponin D	9-23	angiotensin converting enzyme 2	Homo sapiens	303-307
34183961-7	2021	Results: Saikosaponin A (e.g. in Bupleurum chinense), Baicalin (e.g. in several species in the genus Scutellaria), Glycyrrhizin (Glycyrrhiza glabra), MLN-4760 and Umifenovir better occupied ACE2 to inhibit viral RBD binding and are suggested as the top five inhibitors of the SARS-CoV-2 binding site of ACE2.	baicalin	54-62	angiotensin converting enzyme 2	Homo sapiens	190-194
34183961-7	2021	Results: Saikosaponin A (e.g. in Bupleurum chinense), Baicalin (e.g. in several species in the genus Scutellaria), Glycyrrhizin (Glycyrrhiza glabra), MLN-4760 and Umifenovir better occupied ACE2 to inhibit viral RBD binding and are suggested as the top five inhibitors of the SARS-CoV-2 binding site of ACE2.	baicalin	54-62	angiotensin converting enzyme 2	Homo sapiens	303-307
34183961-7	2021	Results: Saikosaponin A (e.g. in Bupleurum chinense), Baicalin (e.g. in several species in the genus Scutellaria), Glycyrrhizin (Glycyrrhiza glabra), MLN-4760 and Umifenovir better occupied ACE2 to inhibit viral RBD binding and are suggested as the top five inhibitors of the SARS-CoV-2 binding site of ACE2.	Glycyrrhizic Acid	115-127	angiotensin converting enzyme 2	Homo sapiens	190-194
34183961-7	2021	Results: Saikosaponin A (e.g. in Bupleurum chinense), Baicalin (e.g. in several species in the genus Scutellaria), Glycyrrhizin (Glycyrrhiza glabra), MLN-4760 and Umifenovir better occupied ACE2 to inhibit viral RBD binding and are suggested as the top five inhibitors of the SARS-CoV-2 binding site of ACE2.	Glycyrrhizic Acid	115-127	angiotensin converting enzyme 2	Homo sapiens	303-307
34230886-12	2021	Firstly, through the downregulation of angiotensin-converting enzyme 2 receptors, resulting in the imbalance of dopamine and norepinephrine; and secondly, the virus could cause cellular vacuolation, demyelination and gliosis, leading to encephalitis and associated movement disorders.	Norepinephrine	125-139	angiotensin converting enzyme 2	Homo sapiens	39-70
34718258-6	2021	General mechanisms of multi-system dysfunction and multi-organ damage reported in COVID-19 are probably related to ubiquitous expression of ACE2 in many tissues and its important role in the renin-angiotensin-aldosterone system (RAAS) functioning.	Aldosterone	209-220	angiotensin converting enzyme 2	Homo sapiens	140-144
34596976-0	2021	Influence of renin-angiotensin-aldosterone system inhibitors on plasma levels of angiotensin-converting enzyme 2.	Aldosterone	31-42	angiotensin converting enzyme 2	Homo sapiens	81-112
34642634-2	2021	Renin-angiotensin-aldosterone system (RAAS) inhibitors have been reported to increase ACE2 in type 2 pneumocyte pulmonary tissue.	Aldosterone	18-29	angiotensin converting enzyme 2	Homo sapiens	86-90
34745440-2	2021	Based on the structure of the complex of the protein S receptor-binding domain (RBD) and ACE2, the design of chimeric molecules consisting of two 22-23-mer peptides linked to each other by disulfide bonds was carried out.	Disulfides	189-198	angiotensin converting enzyme 2	Homo sapiens	89-93
34234394-7	2021	Group-A S protein"s RBD bound imperceptibly to the two binding clefts of the hACE2 protein, on the other hand, Group-B S protein"s RBD perfectly interacted inside the binding clefts of hACE2, with higher number of hydrogen and hydrophobic interactions.	Hydrogen	214-222	angiotensin converting enzyme 2	Homo sapiens	185-190
34495539-5	2021	Modification of SARS-CoV-2 envelope membrane with glycans is important in host immune recognition and interaction between S and ACE2 glycoproteins.	Polysaccharides	50-57	angiotensin converting enzyme 2	Homo sapiens	128-132
34530706-3	2021	The principal activity of ACE2 is to metabolize Ang II into the vasodilatory Ang-(1-7).	Angiotensin II	48-54	angiotensin converting enzyme 2	Homo sapiens	26-30
34906063-2	2021	BACKGROUND: Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which uses angiotensin-converting enzyme 2 (ACE-II) as the first route to infect human cells.	ACE protocol 1	177-183	angiotensin converting enzyme 2	Homo sapiens	144-175
34568544-0	2021	Inhibitory activity of FDA-approved drugs cetilistat, abiraterone, diiodohydroxyquinoline, bexarotene, remdesivir, and hydroxychloroquine on COVID-19 main protease and human ACE2 receptor: A comparative in silico approach.	Hydroxychloroquine	119-137	angiotensin converting enzyme 2	Homo sapiens	174-178
34075338-3	2021	Similarly, a transmembrane serine protease, TMPRSS2 of the host cell plays a significant role in the proteolytic cleavage of viral "S" protein helpful for the priming of ACE2 receptors and viral entry into human cells.	Serine	27-33	angiotensin converting enzyme 2	Homo sapiens	170-174
34568544-6	2021	The calculations revealed that cetilistat, abiraterone, diiodohydroxyquinoline, and bexarotene inhibit main protease and ACE2 receptors more effectively than the well-known drug hydroxychloroquine when used against COVID-19.	cetilistat	31-41	angiotensin converting enzyme 2	Homo sapiens	121-125
34568544-6	2021	The calculations revealed that cetilistat, abiraterone, diiodohydroxyquinoline, and bexarotene inhibit main protease and ACE2 receptors more effectively than the well-known drug hydroxychloroquine when used against COVID-19.	abiraterone	43-54	angiotensin converting enzyme 2	Homo sapiens	121-125
34568544-6	2021	The calculations revealed that cetilistat, abiraterone, diiodohydroxyquinoline, and bexarotene inhibit main protease and ACE2 receptors more effectively than the well-known drug hydroxychloroquine when used against COVID-19.	Iodoquinol	56-78	angiotensin converting enzyme 2	Homo sapiens	121-125
34568544-6	2021	The calculations revealed that cetilistat, abiraterone, diiodohydroxyquinoline, and bexarotene inhibit main protease and ACE2 receptors more effectively than the well-known drug hydroxychloroquine when used against COVID-19.	Bexarotene	84-94	angiotensin converting enzyme 2	Homo sapiens	121-125
34568544-6	2021	The calculations revealed that cetilistat, abiraterone, diiodohydroxyquinoline, and bexarotene inhibit main protease and ACE2 receptors more effectively than the well-known drug hydroxychloroquine when used against COVID-19.	Hydroxychloroquine	178-196	angiotensin converting enzyme 2	Homo sapiens	121-125
34568544-7	2021	Meanwhile, bexarotene and cetilistat bind more tightly to the SARS-CoV-2 main protease and the ACE2 receptor, respectively, than remdesivir, a potential treatment for COVID-19 that is the first FDA-approved drug against this virus.	Bexarotene	11-21	angiotensin converting enzyme 2	Homo sapiens	95-99
34568544-7	2021	Meanwhile, bexarotene and cetilistat bind more tightly to the SARS-CoV-2 main protease and the ACE2 receptor, respectively, than remdesivir, a potential treatment for COVID-19 that is the first FDA-approved drug against this virus.	remdesivir	129-139	angiotensin converting enzyme 2	Homo sapiens	95-99
34966196-1	2021	Introduction: Metformin has known mechanistic benefits on COVID-19 infection due to its anti-inflammatory effects and its action on the ACE2 receptor.	Metformin	14-23	angiotensin converting enzyme 2	Homo sapiens	136-140
34149942-0	2021	Inhalative Steroide senken ACE-2-Genexpression auf dem Bronchialepithel.	steroide	11-19	angiotensin converting enzyme 2	Homo sapiens	27-32
34168100-0	2021	Triglyceride regulate ACE2 level through MTHFD1.	Triglycerides	0-12	angiotensin converting enzyme 2	Homo sapiens	22-26
34168100-5	2021	Furthermore, we examined the ACE2 levels in Calu3 cells (a lung cancer cell line) after triglyceride treatment, and the results indicated that ACE2 levels were increased at 25 muM and reached their peak at 200 muM.	Triglycerides	88-100	angiotensin converting enzyme 2	Homo sapiens	29-33
34168100-5	2021	Furthermore, we examined the ACE2 levels in Calu3 cells (a lung cancer cell line) after triglyceride treatment, and the results indicated that ACE2 levels were increased at 25 muM and reached their peak at 200 muM.	Triglycerides	88-100	angiotensin converting enzyme 2	Homo sapiens	143-147
34168100-7	2021	Given these findings, we hypothesize that triglycerides can regulate the expression of ACE2 and Mthfd1.	Triglycerides	42-55	angiotensin converting enzyme 2	Homo sapiens	87-91
34603638-7	2021	Moreover, the binding free energy and hydrogen bond distribution analysis of RBD-ACE2 binding interface provided the binding motifs that may be critical to allosteric signal transmission and RBD binding.	Hydrogen	38-46	angiotensin converting enzyme 2	Homo sapiens	81-85
34328284-6	2021	Some authors present that smoking and nicotine reduce the amount of the ACE2 receptors which are used by the novel coronavirus to enter cells, while others claim that ACE2 receptors are upregulated in smokers.	Nicotine	38-46	angiotensin converting enzyme 2	Homo sapiens	72-76
34693818-12	2021	The type II transmembrane serine proteases TMPRSS2 and histone acetyltransferases (HAT) are host cell proteases that are recruited by the virus to cleave ACE2 surface protein S which facilitates the viral entry.	Serine	26-32	angiotensin converting enzyme 2	Homo sapiens	154-158
35345413-5	2022	According to in silico results, all phthalimide analogs may block the PPI between S1 and ACE2.	phthalimide	36-47	angiotensin converting enzyme 2	Homo sapiens	89-93
34853776-0	2021	PFOA induces alteration in DNA methylation regulators and SARS-CoV-2 targets Ace2 and Tmprss2 in mouse lung tissues.	perfluorooctanoic acid	0-4	angiotensin converting enzyme 2	Homo sapiens	77-81
35061975-5	2022	Vaccination with pGX-9501 induced subsequent protection against virus challenge in a rigorous hACE2 transgenic mouse model.	pgx-9501	17-25	angiotensin converting enzyme 2	Homo sapiens	94-99
34404266-3	2021	ACE2 receptors are abundantly expressed on dopamine neurons, which may worsen the prognosis of motor symptoms in Parkinson"s disease (PD).	Dopamine	43-51	angiotensin converting enzyme 2	Homo sapiens	0-4
35462797-9	2022	In this study, virtual screening was used to mine the essential oil components of medicinal plants, and it was found that the components could interact with the spike protein RBD in aerosol to block the interaction of RBD and hACE2, thus cutting off the transmission route and protecting the host.	Oils, Volatile	54-67	angiotensin converting enzyme 2	Homo sapiens	226-231
35398454-0	2022	A Novel Plant Lectin, NTL-125, Interferes with SARS-CoV-2 Interaction with hACE2.	ntl-125	22-29	angiotensin converting enzyme 2	Homo sapiens	75-80
35398454-7	2022	In silico docking studies revealed that NTL-125 has strong affinity to viral Spike RBD protein, preventing it from attaching to hACE2 receptor, the gateway to cellular entry.	ntl-125	40-47	angiotensin converting enzyme 2	Homo sapiens	128-133
35595082-9	2022	Interestingly, the U87.ACE2+ cells could be successfully implemented in an MTS-based colorimetric CPE reduction assay, providing IC50 values for Remdesivir and Nirmatrelvir in the (low) nanomolar range.	remdesivir	145-155	angiotensin converting enzyme 2	Homo sapiens	23-27
35487151-0	2022	Inhibitory mechanism of Ambroxol and Bromhexine Hydrochlorides as potent blockers of molecular interaction between SARS-CoV-2 spike protein and human angiotensin-converting Enzyme-2.	Ambroxol	24-32	angiotensin converting enzyme 2	Homo sapiens	150-181
35595082-9	2022	Interestingly, the U87.ACE2+ cells could be successfully implemented in an MTS-based colorimetric CPE reduction assay, providing IC50 values for Remdesivir and Nirmatrelvir in the (low) nanomolar range.	7R9A5P7H32	160-172	angiotensin converting enzyme 2	Homo sapiens	23-27
35487151-0	2022	Inhibitory mechanism of Ambroxol and Bromhexine Hydrochlorides as potent blockers of molecular interaction between SARS-CoV-2 spike protein and human angiotensin-converting Enzyme-2.	Bromhexine	37-62	angiotensin converting enzyme 2	Homo sapiens	150-181
35430474-5	2022	Evaluation of the binding energies of the phytocompounds showed that two compounds, Abrusoside A (-63.393 kcal/mol) and Kaempferol-3-O-rutinoside (-58.939 kcal/mol) had stronger affinity for the exopeptidase site of hACE2 compared to the reference drug, MLN-4760 (-54.545 kcal/mol).	abrusoside A methyl ester	84-96	angiotensin converting enzyme 2	Homo sapiens	216-221
35583118-4	2022	As the proteins approached, the glycan of ACE2 first established a hydrogen bond with the RBD.	Polysaccharides	32-38	angiotensin converting enzyme 2	Homo sapiens	42-46
35430474-5	2022	Evaluation of the binding energies of the phytocompounds showed that two compounds, Abrusoside A (-63.393 kcal/mol) and Kaempferol-3-O-rutinoside (-58.939 kcal/mol) had stronger affinity for the exopeptidase site of hACE2 compared to the reference drug, MLN-4760 (-54.545 kcal/mol).	kaempferol-3-O-rutinoside	120-145	angiotensin converting enzyme 2	Homo sapiens	216-221
35487151-7	2022	However, the binding of AMB (-56.931 kcal/mol) and BHH (-46.354 kcal/mol) at the exopeptidase site of hACE-2, significantly reduced the binding affinities between the proteins compared to the unbound, ACE-2-RBD complex (-64.856 kcal/mol).	amb	24-27	angiotensin converting enzyme 2	Homo sapiens	102-108
35487151-7	2022	However, the binding of AMB (-56.931 kcal/mol) and BHH (-46.354 kcal/mol) at the exopeptidase site of hACE-2, significantly reduced the binding affinities between the proteins compared to the unbound, ACE-2-RBD complex (-64.856 kcal/mol).	amb	24-27	angiotensin converting enzyme 2	Homo sapiens	201-206
35487151-7	2022	However, the binding of AMB (-56.931 kcal/mol) and BHH (-46.354 kcal/mol) at the exopeptidase site of hACE-2, significantly reduced the binding affinities between the proteins compared to the unbound, ACE-2-RBD complex (-64.856 kcal/mol).	Bromhexine	51-54	angiotensin converting enzyme 2	Homo sapiens	102-108
35487151-7	2022	However, the binding of AMB (-56.931 kcal/mol) and BHH (-46.354 kcal/mol) at the exopeptidase site of hACE-2, significantly reduced the binding affinities between the proteins compared to the unbound, ACE-2-RBD complex (-64.856 kcal/mol).	Bromhexine	51-54	angiotensin converting enzyme 2	Homo sapiens	201-206
35487151-9	2022	Residue interaction networks analysis further revealed the binding of the two drugs at the exopeptidase site of hACE-2 reduced the number of interacting amino residues, subsequently leading to loss of interactions between the two proteins, with BHH showing better reduction in the molecular interaction and binding affinity than AMB.	Bromhexine	245-248	angiotensin converting enzyme 2	Homo sapiens	112-118
35487151-9	2022	Residue interaction networks analysis further revealed the binding of the two drugs at the exopeptidase site of hACE-2 reduced the number of interacting amino residues, subsequently leading to loss of interactions between the two proteins, with BHH showing better reduction in the molecular interaction and binding affinity than AMB.	amb	329-332	angiotensin converting enzyme 2	Homo sapiens	112-118
35583118-4	2022	As the proteins approached, the glycan of ACE2 first established a hydrogen bond with the RBD.	Hydrogen	67-75	angiotensin converting enzyme 2	Homo sapiens	42-46
35583118-7	2022	The spatial distribution function of the solvent revealed the presence of hydrogen bonds bridged by water molecules on the RBD-ACE2 interface.	Hydrogen	74-82	angiotensin converting enzyme 2	Homo sapiens	127-131
35583118-7	2022	The spatial distribution function of the solvent revealed the presence of hydrogen bonds bridged by water molecules on the RBD-ACE2 interface.	Water	100-105	angiotensin converting enzyme 2	Homo sapiens	127-131
35601073-7	2022	A strong correlation between the ACE2 rs4343 G>A genotype distribution among COVID-19 patients was reported with respect to their comorbid conditions including sex (P<0.023), coronary artery disease (P<0.0001), oxygen saturation <60 mm Hg (P<0.0009) and antiviral therapy (0.003).	Oxygen	211-217	angiotensin converting enzyme 2	Homo sapiens	33-37
35436443-5	2022	35B5 potently neutralizes SARS-CoV-2 Omicron and other variants by causing significant conformational changes within a conserved N-glycan switch that controls the transition of RBD from the "down" state to the "up" state, which allows recognition of the host entry receptor ACE2.	n-glycan	129-137	angiotensin converting enzyme 2	Homo sapiens	274-278
34981557-0	2022	Inhibitory effect of whey protein concentrate on SARS-CoV-2-targeted furin activity and spike protein-ACE2 binding in methotrexate-induced lung damage.	Methotrexate	118-130	angiotensin converting enzyme 2	Homo sapiens	102-106
35311662-11	2022	DMPC and PMPC markedly inhibited wild type and D614G mutant SARS-CoV-2 infection in HEK293T-ACE2 and Vero-E6 cells.	Dimyristoylphosphatidylcholine	0-4	angiotensin converting enzyme 2	Homo sapiens	92-96
35610002-5	2022	Some flavonoid compounds of Citrus fruits act on Immun-oregulation and target angiotensin-converting enzyme 2 which is used by SARS-COV for entry.	Flavonoids	5-14	angiotensin converting enzyme 2	Homo sapiens	78-109
35311662-11	2022	DMPC and PMPC markedly inhibited wild type and D614G mutant SARS-CoV-2 infection in HEK293T-ACE2 and Vero-E6 cells.	pmpc	9-13	angiotensin converting enzyme 2	Homo sapiens	92-96
35475118-8	2022	Therefore, Abemaciclib, Dasatinib and Spiperone are likely to be viable drug-candidate molecules that can block the interaction between the omicron spike protein and the host cellular receptor ACE2.	abemaciclib	11-22	angiotensin converting enzyme 2	Homo sapiens	193-197
35584293-4	2022	As demonstrated using two models of severe acute respiratory syndrome coronavirus 2, DIVER first tags membraned particles with exogenous oligonucleotides, then captures the tagged particles on beads functionalized with a virus-specific capture agent (in this instance, angiotensin-converting enzyme 2), and finally quantifies the oligonucleotide tags using qPCR.	Oligonucleotides	137-153	angiotensin converting enzyme 2	Homo sapiens	269-300
35584293-4	2022	As demonstrated using two models of severe acute respiratory syndrome coronavirus 2, DIVER first tags membraned particles with exogenous oligonucleotides, then captures the tagged particles on beads functionalized with a virus-specific capture agent (in this instance, angiotensin-converting enzyme 2), and finally quantifies the oligonucleotide tags using qPCR.	Oligonucleotides	330-345	angiotensin converting enzyme 2	Homo sapiens	269-300
35618976-0	2022	Plasma angiotensin peptides as biomarkers of rheumatoid arthritis are correlated with anti-ACE2 auto-antibodies level and disease intensity.	angiotensin peptides	7-27	angiotensin converting enzyme 2	Homo sapiens	91-95
35622184-6	2022	Mechanistically, although Cav-1 counteracted angiotensin-converting enzyme 2 (ACE2) expression, ACE2 positively facilitated resistance to CDDP in OCCC cells.	cddp	138-142	angiotensin converting enzyme 2	Homo sapiens	96-100
35622184-8	2022	Of note, ACE2 positively regulated the expression of the platinum-clearing enzyme CYP3A4.	Platinum	57-65	angiotensin converting enzyme 2	Homo sapiens	9-13
35475118-8	2022	Therefore, Abemaciclib, Dasatinib and Spiperone are likely to be viable drug-candidate molecules that can block the interaction between the omicron spike protein and the host cellular receptor ACE2.	Dasatinib	24-33	angiotensin converting enzyme 2	Homo sapiens	193-197
35475118-8	2022	Therefore, Abemaciclib, Dasatinib and Spiperone are likely to be viable drug-candidate molecules that can block the interaction between the omicron spike protein and the host cellular receptor ACE2.	Spiperone	38-47	angiotensin converting enzyme 2	Homo sapiens	193-197
35625526-4	2022	The docking results indicated that Omicron BA.2 has exceptionally strong interactions with hACE2 in comparison to Omicron BA.1, Delta, and wild-type, as indicated by various parameters such as salt bridge, hydrogen bond, and non-bonded interactions.	Hydrogen	206-214	angiotensin converting enzyme 2	Homo sapiens	91-96
35625526-5	2022	The results of the molecular dynamics simulation study corroborate these findings, indicating that Omicron BA.2 has a strong and stable interaction with hACE2.	omicron ba.	99-110	angiotensin converting enzyme 2	Homo sapiens	153-158
35599487-6	2022	The basis of this hypothesis is the fact that SARS-CoV-2 uses as a receptor angiotensin-converting enzyme 2 to enter the host cell and that this interaction is calcium-dependent.	Calcium	160-167	angiotensin converting enzyme 2	Homo sapiens	76-107
35434540-0	2022	Synthetic Carbohydrate Binding Agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2.	Carbohydrates	10-22	angiotensin converting enzyme 2	Homo sapiens	106-110
35434540-3	2022	Both, virus and ACE2, are highly glycosylated, and exploiting glycans of the SARS-CoV-2 envelope as binding sites for ACE2 represents a virus strategy for attacking the human host.	Polysaccharides	62-69	angiotensin converting enzyme 2	Homo sapiens	16-20
35434540-3	2022	Both, virus and ACE2, are highly glycosylated, and exploiting glycans of the SARS-CoV-2 envelope as binding sites for ACE2 represents a virus strategy for attacking the human host.	Polysaccharides	62-69	angiotensin converting enzyme 2	Homo sapiens	118-122
35492218-7	2022	DHODH inhibitors increased the antiviral efficiency of molnupiravir not only in organoids of human lung, but also in Syrian Gold hamsters and in K18-hACE2 mice.	EIDD 2801	55-67	angiotensin converting enzyme 2	Homo sapiens	149-154
35596222-0	2022	Effective protection of ZF2001 against the SARS-CoV-2 Delta variant in lethal K18-hACE2 mice.	zf2001	24-30	angiotensin converting enzyme 2	Homo sapiens	82-87
35298873-4	2022	The most interesting structural match involved the drug vortioxetine which was then experimentally shown by NMR spectroscopy to bind directly to human ACE2.	Vortioxetine	56-68	angiotensin converting enzyme 2	Homo sapiens	151-155
35629227-6	2022	In a second stage, we performed in vitro assays evaluating the effects of high glucose concentrations on ACE2 gene expression.	Glucose	79-86	angiotensin converting enzyme 2	Homo sapiens	105-109
35631447-1	2022	We have previously identified methylene blue, a tricyclic phenothiazine dye approved for clinical use for the treatment of methemoglobinemia and for other medical applications as a small-molecule inhibitor of the protein-protein interaction (PPI) between the spike protein of the SARS-CoV-2 coronavirus and ACE2, the first critical step of the attachment and entry of this coronavirus responsible for the COVID-19 pandemic.	Methylene Blue	30-44	angiotensin converting enzyme 2	Homo sapiens	307-311
35631447-3	2022	Methylene blue also showed promiscuous activity and inhibited several other PPIs of viral proteins (e.g., HCoV-NL63-ACE2, hepatitis C virus E-CD81) as well as others (e.g., IL-2-IL-2Ralpha) with similar potency.	Methylene Blue	0-14	angiotensin converting enzyme 2	Homo sapiens	116-120
35631447-4	2022	This nonspecificity notwithstanding, methylene blue inhibited the entry of pseudoviruses bearing the spike protein of SARS-CoV-2 in hACE2-expressing host cells, both for the original strain and the delta variant.	Methylene Blue	37-51	angiotensin converting enzyme 2	Homo sapiens	132-137
35221531-2	2022	Herein, a human angiotensin-converting enzyme 2 protein (ACE2) functionalized silver nanotriangle (AgNT) array localized surface plasmon resonance (LSPR) sensor is developed for rapid coronavirus detection, which is validated by SARS-CoV-2 spike RBD protein and CoV NL63 virus with high sensitivity and specificity.	Silver	78-84	angiotensin converting enzyme 2	Homo sapiens	57-61
35579533-6	2022	Oral administration of ATV006 reduced viral loads and alleviated lung damage when administered prophylactically and therapeutically to K18-hACE2 mice challenged with the Delta variant of SARS-CoV-2.	atv006	23-29	angiotensin converting enzyme 2	Homo sapiens	139-144
35578055-6	2022	The strong and stable binding of these safe and cheap vitamins at the important residues (R403, K417, Y449, Y453, N501, and Y505) in the S-protein-ACE2 interface and 3CLpro binding site residues especially active site residues (His 41 and Cys 145), indicating that they could be valuable repurpose drugs for inhibiting SARS-CoV-2 entry into the host and replication.	Histidine	228-231	angiotensin converting enzyme 2	Homo sapiens	147-151
35578055-6	2022	The strong and stable binding of these safe and cheap vitamins at the important residues (R403, K417, Y449, Y453, N501, and Y505) in the S-protein-ACE2 interface and 3CLpro binding site residues especially active site residues (His 41 and Cys 145), indicating that they could be valuable repurpose drugs for inhibiting SARS-CoV-2 entry into the host and replication.	Cysteine	239-242	angiotensin converting enzyme 2	Homo sapiens	147-151
35346677-4	2022	Results showed that, among the main ingredients in the leaves, forsythoside A showed the strongest docking affinities with the proteins SARS-CoV-2-RBD-hACE2 of COVID-19 and its variants (Alpha (B.1.1.7), Beta (B.1.351), and Delta (B.1.617)), as well as neuropilin-1 (NRP1), and SARS-CoV-2 main protease (MPro) to interfere coronavirus entering into the human body.	forsythiaside	63-77	angiotensin converting enzyme 2	Homo sapiens	151-156
35628247-4	2022	Lactoferrin, above 1 microM concentration, thus appears to directly interfere with RBD-ACE2 binding, bringing about a measurable, up to 300-fold increase of the KD value relative to RBD-ACE2 complex formation.	rbd	83-86	angiotensin converting enzyme 2	Homo sapiens	87-91
35549373-6	2022	ACE2 is one of the main enzymes responsible for dampening the primary effector peptide Ang II (angiotensin II), metabolizing it to Ang-(1-7).	Angiotensin II	87-93	angiotensin converting enzyme 2	Homo sapiens	0-4
35549865-9	2022	Of interest, restoration of NO by L-arginine may attenuate SARS-CoV-2 infection through different mechanisms, including reduction binding of SARS-CoV-2 to ACE2, inhibition of transmembrane protease serine type 2 (TMPRSS2) a critical for activation of SARS-CoV-2 spike protein and cellular entry, inhibition proliferation and replication of SARS-CoV-2, and prevention of SARS-CoV-2-induced coagulopathy.	Arginine	34-44	angiotensin converting enzyme 2	Homo sapiens	155-159
35596971-0	2022	Computational studies evidenced the potential of steroidal lactone to disrupt surface interaction of SARS-CoV-2 spike protein and hACE2.	Lactones	59-66	angiotensin converting enzyme 2	Homo sapiens	130-135
35596971-5	2022	Under CON-II, Withalongolide A was capable of disrupting all types of PPI, as evidenced by an increased BE from -913 kJ/mol (control) to -133.69 kJ/mol and an increased distance (>3.55 nm) between selected AAR combinations of S-RBD and hACE2-R. Withalongolide A formed a hydrogen bond with TYR453 (97%, HBO) of S-RBD, which is required for interaction with hACE2-R"s HIS34.	Withalongolide A	14-30	angiotensin converting enzyme 2	Homo sapiens	236-241
35596971-5	2022	Under CON-II, Withalongolide A was capable of disrupting all types of PPI, as evidenced by an increased BE from -913 kJ/mol (control) to -133.69 kJ/mol and an increased distance (>3.55 nm) between selected AAR combinations of S-RBD and hACE2-R. Withalongolide A formed a hydrogen bond with TYR453 (97%, HBO) of S-RBD, which is required for interaction with hACE2-R"s HIS34.	Withalongolide A	14-30	angiotensin converting enzyme 2	Homo sapiens	357-362
35632499-3	2022	Our data demonstrate that both Delta, as well as Omicron variants, exhibit a higher affinity for the receptor ACE2, facilitating infection and causing antibody escape by receptor affinity (affinity escape), due to the reduced ability of antibodies to compete with RBD-receptor interaction and virus neutralization.	delta	31-36	angiotensin converting enzyme 2	Homo sapiens	110-114
35538813-0	2022	Reduction of ACE2 serum concentrations by telbivudine in chronic hepatitis B patients.	Telbivudine	42-53	angiotensin converting enzyme 2	Homo sapiens	13-17
35229496-6	2022	In the North American cohort, all five patients with anti-ACE2 IgM antibodies had proximal muscle weakness, had interstitial lung disease, were significantly more likely to receive pulse dose methylprednisolone (80% vs 30%, P = 0.043), and had worse forced vital capacity (median 59% predicted vs 78%, P = 0.056) compared with the anti-ACE2-IgM-negative group.	Methylprednisolone	192-210	angiotensin converting enzyme 2	Homo sapiens	58-62
35526097-2	2022	Following a screen of 1,200 FDA-approved compounds, we identified Bifonazole, an imidazole-based antifungal, as a competitive inhibitor of RBD-ACE2 binding.	bifonazole	66-76	angiotensin converting enzyme 2	Homo sapiens	143-147
35526097-2	2022	Following a screen of 1,200 FDA-approved compounds, we identified Bifonazole, an imidazole-based antifungal, as a competitive inhibitor of RBD-ACE2 binding.	imidazole	81-90	angiotensin converting enzyme 2	Homo sapiens	143-147
35526097-3	2022	Mechanistically, Bifonazole binds ACE2 around residue K353, which consequently prevents association with RBD, thereby impacting entry and replication of Spike-pseudotyped viruses as well as native SARS-CoV-2 and its variants of concern (VOC).	bifonazole	17-27	angiotensin converting enzyme 2	Homo sapiens	34-38
35526097-3	2022	Mechanistically, Bifonazole binds ACE2 around residue K353, which consequently prevents association with RBD, thereby impacting entry and replication of Spike-pseudotyped viruses as well as native SARS-CoV-2 and its variants of concern (VOC).	Fluoroglycofen	54-58	angiotensin converting enzyme 2	Homo sapiens	34-38
35547841-4	2022	With examples of zwitterionic dipalmitoyl phosphatidyl choline, cholesterol, and anionic sodium dodecyl sulphate, we show that surfactants form micellar aggregates that selectively adhere to the specific regions of S1 domain of the Spike protein that are responsible for binding with ACE2 receptors and virus transmission into the cells.	Cholesterol	64-75	angiotensin converting enzyme 2	Homo sapiens	284-288
35547841-4	2022	With examples of zwitterionic dipalmitoyl phosphatidyl choline, cholesterol, and anionic sodium dodecyl sulphate, we show that surfactants form micellar aggregates that selectively adhere to the specific regions of S1 domain of the Spike protein that are responsible for binding with ACE2 receptors and virus transmission into the cells.	Sodium Dodecyl Sulfate	89-112	angiotensin converting enzyme 2	Homo sapiens	284-288
35442638-8	2022	Finally, we evaluated two ACE2 inhibitors, Ramipril and Perindopril, and found the dose-dependent inhibition of ACE2 binding to all the spike variants except for B.1.617.3.	Ramipril	43-51	angiotensin converting enzyme 2	Homo sapiens	26-30
35442638-8	2022	Finally, we evaluated two ACE2 inhibitors, Ramipril and Perindopril, and found the dose-dependent inhibition of ACE2 binding to all the spike variants except for B.1.617.3.	Ramipril	43-51	angiotensin converting enzyme 2	Homo sapiens	112-116
35442638-8	2022	Finally, we evaluated two ACE2 inhibitors, Ramipril and Perindopril, and found the dose-dependent inhibition of ACE2 binding to all the spike variants except for B.1.617.3.	Perindopril	56-67	angiotensin converting enzyme 2	Homo sapiens	26-30
35442638-8	2022	Finally, we evaluated two ACE2 inhibitors, Ramipril and Perindopril, and found the dose-dependent inhibition of ACE2 binding to all the spike variants except for B.1.617.3.	Perindopril	56-67	angiotensin converting enzyme 2	Homo sapiens	112-116
35547841-4	2022	With examples of zwitterionic dipalmitoyl phosphatidyl choline, cholesterol, and anionic sodium dodecyl sulphate, we show that surfactants form micellar aggregates that selectively adhere to the specific regions of S1 domain of the Spike protein that are responsible for binding with ACE2 receptors and virus transmission into the cells.	1,2-Dipalmitoylphosphatidylcholine	30-62	angiotensin converting enzyme 2	Homo sapiens	284-288
35563515-3	2022	By infectivity and spike-mediated cell-cell fusion assays, we showed that Ang II acting on the angiotensin type 1 receptor markedly increased ACE2 at mRNA and protein levels, resulting in enhanced SARS-CoV-2 cell entry.	angiotensin type 1	95-113	angiotensin converting enzyme 2	Homo sapiens	142-146
35563515-4	2022	These effects were abolished by irbesartan and not affected by the blockade of ACE-1-mediated Ang II formation with ramipril, and of ACE2- mediated Ang II conversion into Ang 1-7 with MLN-4760.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	184-192	angiotensin converting enzyme 2	Homo sapiens	133-137
35229496-7	2022	In the Japanese cohort, all five anti-ACE2-IgM-positive patients also required pulse dose methylprednisolone, and three of five (60%) patients died.	Methylprednisolone	90-108	angiotensin converting enzyme 2	Homo sapiens	38-42
35229496-8	2022	Japanese patients with anti-ACE2 IgM had significantly worse oxygenation, as defined by a lower partial pressure of oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratio (233 vs 390, P = 0.021), and a higher alveolar-arterial oxygenation gradient (91 vs 23 mm Hg, P = 0.024) than the IgM-negative group.	Oxygen	116-122	angiotensin converting enzyme 2	Homo sapiens	28-32
35229496-8	2022	Japanese patients with anti-ACE2 IgM had significantly worse oxygenation, as defined by a lower partial pressure of oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratio (233 vs 390, P = 0.021), and a higher alveolar-arterial oxygenation gradient (91 vs 23 mm Hg, P = 0.024) than the IgM-negative group.	Oxygen	151-157	angiotensin converting enzyme 2	Homo sapiens	28-32
35229496-6	2022	In the North American cohort, all five patients with anti-ACE2 IgM antibodies had proximal muscle weakness, had interstitial lung disease, were significantly more likely to receive pulse dose methylprednisolone (80% vs 30%, P = 0.043), and had worse forced vital capacity (median 59% predicted vs 78%, P = 0.056) compared with the anti-ACE2-IgM-negative group.	Methylprednisolone	192-210	angiotensin converting enzyme 2	Homo sapiens	336-340
35279013-6	2022	In the compositions of GB-1, glycyrrhizic acid can inhibit the binding between ACE2 and RBD with Wuhan type, except K417N-E484K-N501Y mutation.	Glycyrrhizic Acid	29-46	angiotensin converting enzyme 2	Homo sapiens	79-83
35229496-8	2022	Japanese patients with anti-ACE2 IgM had significantly worse oxygenation, as defined by a lower partial pressure of oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratio (233 vs 390, P = 0.021), and a higher alveolar-arterial oxygenation gradient (91 vs 23 mm Hg, P = 0.024) than the IgM-negative group.	fio2	159-163	angiotensin converting enzyme 2	Homo sapiens	28-32
35419694-5	2022	Using a previously described AlphaScreen-based protein interaction assay, we show here that the DCM:MeOH extract of G. perpensa readily disrupts RBD (USA-WA1/2020)-ACE2 interactions with a half-maximal inhibition concentration (IC50) of < 0.001 microg/mL, compared to an IC50 of 0.025 microg/mL for the control neutralising antibody REGN10987.	dcm	96-99	angiotensin converting enzyme 2	Homo sapiens	164-168
35419694-5	2022	Using a previously described AlphaScreen-based protein interaction assay, we show here that the DCM:MeOH extract of G. perpensa readily disrupts RBD (USA-WA1/2020)-ACE2 interactions with a half-maximal inhibition concentration (IC50) of < 0.001 microg/mL, compared to an IC50 of 0.025 microg/mL for the control neutralising antibody REGN10987.	Methanol	100-104	angiotensin converting enzyme 2	Homo sapiens	164-168
35624740-7	2022	The literature reveals that quercetin exhibits anti-COVID-19 activity because of its inhibitory effect on the expression of the human ACE2 receptors and the enzymes of SARS-CoV-2 (MPro, PLPro, and RdRp).	Quercetin	28-37	angiotensin converting enzyme 2	Homo sapiens	134-138
35344983-7	2022	Importantly, in the K18-human ACE2 transgenic mouse model of severe SARS-CoV-2 disease, we found that N-0385 affords a high level of prophylactic and therapeutic benefit following either multiple or even a single administration.	Ms-QFR-Kbt	102-108	angiotensin converting enzyme 2	Homo sapiens	30-34
35095308-5	2022	Objectives: The objectives of the present study were to conduct an in-silico analysis to investigate if melatonin and related drugs namely ramelteon and agomelatine could be used as antiviral agents in SARS-CoV-2 infection based on their binding to the SARS-CoV-2 receptor binding site (RBD) and Angiotensin-converting enzyme 2 (ACE 2).	Melatonin	104-113	angiotensin converting enzyme 2	Homo sapiens	296-327
35095308-5	2022	Objectives: The objectives of the present study were to conduct an in-silico analysis to investigate if melatonin and related drugs namely ramelteon and agomelatine could be used as antiviral agents in SARS-CoV-2 infection based on their binding to the SARS-CoV-2 receptor binding site (RBD) and Angiotensin-converting enzyme 2 (ACE 2).	Melatonin	104-113	angiotensin converting enzyme 2	Homo sapiens	329-334
35095308-12	2022	Results: Data from the present study reveal that melatonin, ramelteon, and agomelatine demonstrate significant binding with SARS-CoV-2 RBD and ACE 2 demonstrating the fact that they can strongly prevent viral entry into the host cells through dual binding effects.	Melatonin	49-58	angiotensin converting enzyme 2	Homo sapiens	143-148
35095308-12	2022	Results: Data from the present study reveal that melatonin, ramelteon, and agomelatine demonstrate significant binding with SARS-CoV-2 RBD and ACE 2 demonstrating the fact that they can strongly prevent viral entry into the host cells through dual binding effects.	ramelteon	60-69	angiotensin converting enzyme 2	Homo sapiens	143-148
35095308-12	2022	Results: Data from the present study reveal that melatonin, ramelteon, and agomelatine demonstrate significant binding with SARS-CoV-2 RBD and ACE 2 demonstrating the fact that they can strongly prevent viral entry into the host cells through dual binding effects.	agomelatine	75-86	angiotensin converting enzyme 2	Homo sapiens	143-148
35533461-7	2022	The higher TBE for the A.30 RBD complex signifies a more robust interaction between A.30 variant RBD with ACE2 than the wild type, allowing the variant to bind and spread more promptly.	tbe	11-14	angiotensin converting enzyme 2	Homo sapiens	106-110
35199858-0	2022	Challenges with the proposed ACE2 activation mechanism of diminazene aceturate.	diminazene aceturate	58-78	angiotensin converting enzyme 2	Homo sapiens	29-33
35477751-7	2022	Oral treatment with Y180 displayed a remarkable antiviral potency and substantially ameliorated the virus-induced tissue damage in both nasal turbinate and lung of B.1.1.7-infected K18-human ACE2 (K18-hACE2) transgenic mice.	y180	20-24	angiotensin converting enzyme 2	Homo sapiens	191-195
35477751-7	2022	Oral treatment with Y180 displayed a remarkable antiviral potency and substantially ameliorated the virus-induced tissue damage in both nasal turbinate and lung of B.1.1.7-infected K18-human ACE2 (K18-hACE2) transgenic mice.	y180	20-24	angiotensin converting enzyme 2	Homo sapiens	201-206
35508082-7	2022	Further, it was found that curcumin could disrupt the Omicron S-hACE2 complex.	Curcumin	27-35	angiotensin converting enzyme 2	Homo sapiens	64-69
35412405-1	2022	INTRODUCTION: The main route of transmission of SARS-CoV-2 is the upper respiratory tract via cell membranes, including angiotensin-converting enzyme 2 (ACE2) and transmembrane host-associated serine protease transmembrane serine protease 2 (TMPRSS2).	Serine	223-229	angiotensin converting enzyme 2	Homo sapiens	153-157
35566148-7	2022	Furthermore, cannabichromanon (32), cannabinolic acid (22), and cannabinol (21) showed considerable fitting within the active sites of angiotensin-converting enzyme 2 (ACE2) evidenced by their significant  G values that were estimated as -41.77, -31.34, and -30.36 kcal/mol, respectively.	UNII-CVK7769BHC	13-29	angiotensin converting enzyme 2	Homo sapiens	135-166
35566148-7	2022	Furthermore, cannabichromanon (32), cannabinolic acid (22), and cannabinol (21) showed considerable fitting within the active sites of angiotensin-converting enzyme 2 (ACE2) evidenced by their significant  G values that were estimated as -41.77, -31.34, and -30.36 kcal/mol, respectively.	UNII-CVK7769BHC	13-29	angiotensin converting enzyme 2	Homo sapiens	168-172
35566148-7	2022	Furthermore, cannabichromanon (32), cannabinolic acid (22), and cannabinol (21) showed considerable fitting within the active sites of angiotensin-converting enzyme 2 (ACE2) evidenced by their significant  G values that were estimated as -41.77, -31.34, and -30.36 kcal/mol, respectively.	cannabinolic acid	36-53	angiotensin converting enzyme 2	Homo sapiens	135-166
35566148-7	2022	Furthermore, cannabichromanon (32), cannabinolic acid (22), and cannabinol (21) showed considerable fitting within the active sites of angiotensin-converting enzyme 2 (ACE2) evidenced by their significant  G values that were estimated as -41.77, -31.34, and -30.36 kcal/mol, respectively.	cannabinolic acid	36-53	angiotensin converting enzyme 2	Homo sapiens	168-172
35566148-7	2022	Furthermore, cannabichromanon (32), cannabinolic acid (22), and cannabinol (21) showed considerable fitting within the active sites of angiotensin-converting enzyme 2 (ACE2) evidenced by their significant  G values that were estimated as -41.77, -31.34, and -30.36 kcal/mol, respectively.	Cannabinol	64-74	angiotensin converting enzyme 2	Homo sapiens	135-166
35566148-7	2022	Furthermore, cannabichromanon (32), cannabinolic acid (22), and cannabinol (21) showed considerable fitting within the active sites of angiotensin-converting enzyme 2 (ACE2) evidenced by their significant  G values that were estimated as -41.77, -31.34, and -30.36 kcal/mol, respectively.	Cannabinol	64-74	angiotensin converting enzyme 2	Homo sapiens	168-172
35468992-8	2022	6-OAP (2.5 microM) inhibited the interaction between Stat3 protein and ACE2 promoter, thus suppressed ACE2 transcription.	6-O-angeloylprenolin	0-5	angiotensin converting enzyme 2	Homo sapiens	71-75
35572668-7	2022	The pre-treatment of teicoplanin also prevented SARS-CoV-2 infection in hACE2 mice.	Teicoplanin	21-32	angiotensin converting enzyme 2	Homo sapiens	72-77
35483427-0	2022	Alcohol Increases Lung Angiotensin-Converting Enzyme 2 Expression and Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Subunit 1-Induced Acute Lung Injury in K18-hACE2 Transgenic Mice.	Alcohols	0-7	angiotensin converting enzyme 2	Homo sapiens	23-54
35483427-0	2022	Alcohol Increases Lung Angiotensin-Converting Enzyme 2 Expression and Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Subunit 1-Induced Acute Lung Injury in K18-hACE2 Transgenic Mice.	Alcohols	0-7	angiotensin converting enzyme 2	Homo sapiens	187-192
35468992-8	2022	6-OAP (2.5 microM) inhibited the interaction between Stat3 protein and ACE2 promoter, thus suppressed ACE2 transcription.	6-O-angeloylprenolin	0-5	angiotensin converting enzyme 2	Homo sapiens	102-106
35468992-7	2022	Among the 64 compounds tested, 6-O-angeloylplenolin (6-OAP), a sesquiterpene lactone in Chinese medicinal herb Centipeda minima (CM), represented the most potent ACE2 repressor.	6-O-angeloylprenolin	31-51	angiotensin converting enzyme 2	Homo sapiens	162-166
35631327-2	2022	Binding of the severe acute respiratory syndrome coronavirus 2 spike protein (SARS-CoV-2 S protein) to angiotensin-converting enzyme 2 (ACE2), along with proteolytic digestion of the S protein by furin and transmembrane protease serine subtype 2 (TMPRSS2), provokes internalization of SARS-CoV-2 into the host cell.	Serine	229-235	angiotensin converting enzyme 2	Homo sapiens	103-134
35468992-7	2022	Among the 64 compounds tested, 6-O-angeloylplenolin (6-OAP), a sesquiterpene lactone in Chinese medicinal herb Centipeda minima (CM), represented the most potent ACE2 repressor.	6-O-angeloylprenolin	53-58	angiotensin converting enzyme 2	Homo sapiens	162-166
35547740-6	2022	Most of the hcAbs hindered RBD binding to its human ACE2 (hACE2) receptor, blocked cell entry of viruses pseudotyped with the S protein and neutralized SARS-CoV-2 infection in cell cultures.	hcabs	12-17	angiotensin converting enzyme 2	Homo sapiens	58-63
35547740-7	2022	Four potent neutralizing hcAbs prevented the progression to lethal SARS-CoV-2 infection in hACE2-transgenic mice, demonstrating their therapeutic potential.	hcabs	25-30	angiotensin converting enzyme 2	Homo sapiens	91-96
35548336-8	2022	Investigating the effects of recombinant SARS-CoV-2 spike protein S1 Receptor-Binding Domain (Spike) on ACE2 expression in cultured human coronary artery endothelial cells, we found that the presence of histamine potentiated spike-mediated ACE2 internalization into endothelial cells.	Histamine	203-212	angiotensin converting enzyme 2	Homo sapiens	104-108
35548336-10	2022	Together, these results indicate that histamine and histamine receptor signaling is likely essential for spike protein to induce ACE2 internalization in endothelial cells and cause endothelial dysfunction and that this effect can be blocked by the H2R blocker, famotidine.	Histamine	38-47	angiotensin converting enzyme 2	Homo sapiens	129-133
35548336-10	2022	Together, these results indicate that histamine and histamine receptor signaling is likely essential for spike protein to induce ACE2 internalization in endothelial cells and cause endothelial dysfunction and that this effect can be blocked by the H2R blocker, famotidine.	Histamine	52-61	angiotensin converting enzyme 2	Homo sapiens	129-133
35548336-10	2022	Together, these results indicate that histamine and histamine receptor signaling is likely essential for spike protein to induce ACE2 internalization in endothelial cells and cause endothelial dysfunction and that this effect can be blocked by the H2R blocker, famotidine.	Famotidine	261-271	angiotensin converting enzyme 2	Homo sapiens	129-133
35470645-5	2022	Among them, astragaloside exhibited the highest binding affinity -21.8 kcal/mol and stable interactions within the active site of the ACE-2 receptor.	astragaloside	12-25	angiotensin converting enzyme 2	Homo sapiens	134-139
35461388-0	2022	Probing the competitive inhibitor efficacy of frog-skin alpha helical AMPs identified against ACE2 binding to SARS-CoV-2 S1 spike protein as therapeutic scaffold to prevent COVID-19.	adenosine 5'-phosphorothioate	70-74	angiotensin converting enzyme 2	Homo sapiens	94-98
35380569-1	2022	The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells.	Polysaccharides	55-62	angiotensin converting enzyme 2	Homo sapiens	131-135
35446879-8	2022	Moreover, all-atom molecular dynamics simulations concluded that the RBD of the Omicron variant exhibits a more dispersed interaction network since mutations resulted in an increased number of hydrophobic interactions and hydrogen bonds with hACE2.	Hydrogen	222-230	angiotensin converting enzyme 2	Homo sapiens	242-247
35605406-0	2022	Highly polymerized proanthocyanidins (PAC) components from blueberry leaf and stem significantly inhibit SARS-CoV-2 infection via inhibition of ACE2 and viral 3CLpro enzymes.	Proanthocyanidins	19-36	angiotensin converting enzyme 2	Homo sapiens	144-148
35605406-0	2022	Highly polymerized proanthocyanidins (PAC) components from blueberry leaf and stem significantly inhibit SARS-CoV-2 infection via inhibition of ACE2 and viral 3CLpro enzymes.	Proanthocyanidins	38-41	angiotensin converting enzyme 2	Homo sapiens	144-148
35605406-8	2022	Moreover, BB-PAC Fr7 inhibited the activity of angiotensin II converting enzyme (ACE2), although no effect was observed in a neutralization test of pseudotyped SARS-CoV-2.	bb-pac	10-16	angiotensin converting enzyme 2	Homo sapiens	81-85
35631327-2	2022	Binding of the severe acute respiratory syndrome coronavirus 2 spike protein (SARS-CoV-2 S protein) to angiotensin-converting enzyme 2 (ACE2), along with proteolytic digestion of the S protein by furin and transmembrane protease serine subtype 2 (TMPRSS2), provokes internalization of SARS-CoV-2 into the host cell.	Serine	229-235	angiotensin converting enzyme 2	Homo sapiens	136-140
35574509-8	2022	Among these, the one with two lactam stapling agents has shown binding affinity, sufficient to overcome RBD-ACE2 binding.	Lactams	30-36	angiotensin converting enzyme 2	Homo sapiens	108-112
35441076-9	2022	Conclusions: Our results suggest that CPC inhibits the interaction between S protein and ACE2, and thus, reduces infectivity of SARS-CoV-2 and suppresses viral adsorption.	Cetylpyridinium	38-41	angiotensin converting enzyme 2	Homo sapiens	89-93
35463998-0	2022	Tryptophan Metabolism and COVID-19-Induced Skeletal Muscle Damage: Is ACE2 a Key Regulator?	Tryptophan	0-10	angiotensin converting enzyme 2	Homo sapiens	70-74
35457160-5	2022	The intranasal administration of sphingosine has been proposed to prevent the binding of SARS-CoV-2 to ACE2.	Sphingosine	33-44	angiotensin converting enzyme 2	Homo sapiens	103-107
35458513-3	2022	Accordingly, point mutations that result in an increase in electropositively charged residues, e.g., arginine and lysine, especially in the RBD of spike proteins in the SARS-CoV-2 variants, could contribute to their spreading capacity by favoring their recognition by the electronegatively charged ACE2 receptors.	Arginine	101-109	angiotensin converting enzyme 2	Homo sapiens	298-302
35458513-3	2022	Accordingly, point mutations that result in an increase in electropositively charged residues, e.g., arginine and lysine, especially in the RBD of spike proteins in the SARS-CoV-2 variants, could contribute to their spreading capacity by favoring their recognition by the electronegatively charged ACE2 receptors.	Lysine	114-120	angiotensin converting enzyme 2	Homo sapiens	298-302
35458513-5	2022	Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2.	Lysine	0-6	angiotensin converting enzyme 2	Homo sapiens	66-70
35458513-5	2022	Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2.	Lysine	0-6	angiotensin converting enzyme 2	Homo sapiens	194-198
35458513-5	2022	Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2.	Arginine	11-19	angiotensin converting enzyme 2	Homo sapiens	66-70
35458513-5	2022	Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2.	Arginine	11-19	angiotensin converting enzyme 2	Homo sapiens	194-198
35458513-5	2022	Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2.	aspartic	153-161	angiotensin converting enzyme 2	Homo sapiens	66-70
35458513-5	2022	Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2.	aspartic	153-161	angiotensin converting enzyme 2	Homo sapiens	194-198
35458513-5	2022	Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2.	Glutamic Acid	166-179	angiotensin converting enzyme 2	Homo sapiens	66-70
35458513-5	2022	Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2.	Glutamic Acid	166-179	angiotensin converting enzyme 2	Homo sapiens	194-198
35458513-6	2022	However, the effects of lysine- and arginine-generating point mutations on infectivity is more contrasted, since the overall binding affinity of omicron RBD for ACE2 apparently results from some epistasis among the whole set of point mutations.	Lysine	24-30	angiotensin converting enzyme 2	Homo sapiens	161-165
35458513-6	2022	However, the effects of lysine- and arginine-generating point mutations on infectivity is more contrasted, since the overall binding affinity of omicron RBD for ACE2 apparently results from some epistasis among the whole set of point mutations.	Arginine	36-44	angiotensin converting enzyme 2	Homo sapiens	161-165
35463998-3	2022	In addition to acting as a receptor for severe acute respiratory syndrome coronavirus 2, the causative virus of COVID-19, angiotensin converting enzyme 2 (ACE2) contributes to tryptophan absorption and inhibition of the renin-angiotensin system.	Tryptophan	176-186	angiotensin converting enzyme 2	Homo sapiens	122-153
35463998-3	2022	In addition to acting as a receptor for severe acute respiratory syndrome coronavirus 2, the causative virus of COVID-19, angiotensin converting enzyme 2 (ACE2) contributes to tryptophan absorption and inhibition of the renin-angiotensin system.	Tryptophan	176-186	angiotensin converting enzyme 2	Homo sapiens	155-159
35463998-4	2022	In this article, we review previous studies to assess the potential for a link between tryptophan metabolism, ACE2, and skeletal muscle damage in patients with COVID-19.	Tryptophan	87-97	angiotensin converting enzyme 2	Homo sapiens	110-114
35514788-0	2022	Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron-regulatory elements: Potential implications for SARS-CoV-2 infection.	Iron	83-87	angiotensin converting enzyme 2	Homo sapiens	52-56
35230146-5	2022	Compared to the fully glycosylated S protein, immunization of S protein with N-glycans trimmed to the mono-GlcNAc-decorated state (SMG) elicited stronger immune responses and better protection for human angiotensin converting enzyme 2 (hACE2) transgenic mice against variants of concern (VOCs).	n-glycans	77-86	angiotensin converting enzyme 2	Homo sapiens	203-234
35409412-5	2022	With molecular docking, we showed that both Etravirine and Dolutegravir are preferentially bound to primary ACE2-interacting residues on the RBD domain, implying that these two drug blocks may prohibit the viral attachment of SARS-CoV-2.	etravirine	44-54	angiotensin converting enzyme 2	Homo sapiens	108-112
35385928-4	2022	Breathing air with high concentrations of nitrogen dioxide and PM can result in over-expression of the angiotensin converting enzyme-2 (ACE-2) leading to stress of organs, such as heart and kidneys.	Nitrogen	42-50	angiotensin converting enzyme 2	Homo sapiens	103-134
35385928-4	2022	Breathing air with high concentrations of nitrogen dioxide and PM can result in over-expression of the angiotensin converting enzyme-2 (ACE-2) leading to stress of organs, such as heart and kidneys.	Nitrogen	42-50	angiotensin converting enzyme 2	Homo sapiens	136-141
35409412-5	2022	With molecular docking, we showed that both Etravirine and Dolutegravir are preferentially bound to primary ACE2-interacting residues on the RBD domain, implying that these two drug blocks may prohibit the viral attachment of SARS-CoV-2.	dolutegravir	59-71	angiotensin converting enzyme 2	Homo sapiens	108-112
35230146-5	2022	Compared to the fully glycosylated S protein, immunization of S protein with N-glycans trimmed to the mono-GlcNAc-decorated state (SMG) elicited stronger immune responses and better protection for human angiotensin converting enzyme 2 (hACE2) transgenic mice against variants of concern (VOCs).	n-glycans	77-86	angiotensin converting enzyme 2	Homo sapiens	236-241
35296418-4	2022	Only 1Ba-3H exhibited the neutralizing activity for preventing the pseudotyped lentivirus from binding to the angiotensin-converting enzyme 2 (ACE2)-transfected HEK293T cells.	1ba-3h	5-11	angiotensin converting enzyme 2	Homo sapiens	110-141
35411336-5	2022	Accordingly, we developed dual-mechanism aminoadamantane nitrate compounds that inhibit viral entry and thus spread of infection by S-nitrosylating ACE2 via targeted delivery of the drug after E-protein channel blockade.	aminoadamantane nitrate	41-64	angiotensin converting enzyme 2	Homo sapiens	148-152
35138176-8	2022	In addition, the pathway analysis revealed that ACE2 may regulate the differently expressed genes in heart failure through calcium signaling pathway and Wnt signaling pathway.	Calcium	123-130	angiotensin converting enzyme 2	Homo sapiens	48-52
35388061-8	2022	We utilized a system to quantify in real-time cell-cell membrane fusion mediated by the SARS-CoV-2 surface protein, Spike, and its receptor, hACE2, to demonstrate that imatinib inhibits this process in an Abl1 and Abl2 independent manner.	Imatinib Mesylate	168-176	angiotensin converting enzyme 2	Homo sapiens	141-146
35296418-4	2022	Only 1Ba-3H exhibited the neutralizing activity for preventing the pseudotyped lentivirus from binding to the angiotensin-converting enzyme 2 (ACE2)-transfected HEK293T cells.	1ba-3h	5-11	angiotensin converting enzyme 2	Homo sapiens	143-147
35296418-5	2022	The competitive ELISA further showed that 1Ba-3H interfered with the binding between RBD and ACE2.	1ba-3h	42-48	angiotensin converting enzyme 2	Homo sapiens	93-97
35475417-5	2022	Functional assays demonstrated that ACE2 addition promoted cell viability, suppressed apoptosis, oxidative stress, ROS generation, and inflammation in HG-stimulated HMEC-1 cells.	ros	115-118	angiotensin converting enzyme 2	Homo sapiens	36-40
35475417-6	2022	Furthermore, the activation of the JAK2/STAT3 pathway induced by HG was impeded by overexpression of ACE2.	Mercury	65-67	angiotensin converting enzyme 2	Homo sapiens	101-105
35475417-7	2022	Besides, JAK2/STAT3 pathway inhibitor AG490 reversed the changes of cell viability, apoptosis, oxidative stress, and inflammation caused by ACE2 deletion in HG-treated HMEC-1 cells.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	38-43	angiotensin converting enzyme 2	Homo sapiens	140-144
35331159-3	2022	METHODS: We investigated telmisartan, linagliptin and empagliflozin induced effects on renal and cardiac expression of ACE2, TMPRSS2 and key enzymes involved in RAAS (REN, AGTR2, AGT) under high-salt conditions in a non-diabetic experimental 5/6 nephrectomy (5/6 Nx) model.	Telmisartan	25-36	angiotensin converting enzyme 2	Homo sapiens	119-123
35406751-0	2022	GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation.	Bile Acids and Salts	60-69	angiotensin converting enzyme 2	Homo sapiens	37-41
35194375-0	2022	In silico investigations of heparin binding to SARS-CoV-2 variants with a focus at the RBD/ACE2 interface.	Heparin	28-35	angiotensin converting enzyme 2	Homo sapiens	91-95
35194375-2	2022	Several studies have indicated that heparin and its derivatives interact to SARS-CoV-2 S-RBD and inhibits the binding of ACE2 which blocks the viral invasion.	Heparin	36-43	angiotensin converting enzyme 2	Homo sapiens	121-125
35194375-3	2022	However, it is largely unclear how these SARS-CoV-2 variants affects ACE2 binding in the presence of heparin.	Heparin	101-108	angiotensin converting enzyme 2	Homo sapiens	69-73
35194375-6	2022	Further, we showed that most of the RBD mutations increased the binding affinity of ACE2 in the absence of heparin, with the maximum increase observed for N501Y (-13.7 kcal/mol).	Heparin	107-114	angiotensin converting enzyme 2	Homo sapiens	84-88
35194375-7	2022	Also, in the presence of heparin, ACE2 binds strongly to the mutant RBD as compared to WT RBD.	Heparin	25-32	angiotensin converting enzyme 2	Homo sapiens	34-38
35194375-8	2022	The strong RBD/ACE2 interaction was observed in case of triple variants (-11.3 kcal/mol) whereas, N501Y showed weakest binding of RBD/ACE2 in the presence of heparin (-9.2 kcal/mol).	Heparin	158-165	angiotensin converting enzyme 2	Homo sapiens	134-138
35194375-9	2022	The strong binding of ACE2 to RBD-heparin complex in these variants will leads to strong inhibition of their entry into host cells.	rbd	30-33	angiotensin converting enzyme 2	Homo sapiens	22-26
35194375-9	2022	The strong binding of ACE2 to RBD-heparin complex in these variants will leads to strong inhibition of their entry into host cells.	Heparin	34-41	angiotensin converting enzyme 2	Homo sapiens	22-26
35378764-0	2022	An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2.	Barium	93-95	angiotensin converting enzyme 2	Homo sapiens	14-18
35378764-0	2022	An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2.	Barium	102-104	angiotensin converting enzyme 2	Homo sapiens	14-18
35401674-0	2022	Anti-Fungal Drug Anidulafungin Inhibits SARS-CoV-2 Spike-Induced Syncytia Formation by Targeting ACE2-Spike Protein Interaction.	Anidulafungin	17-30	angiotensin converting enzyme 2	Homo sapiens	97-101
35401674-4	2022	Three drug candidates (i.e., anidulafungin, lopinavir, and indinavir) were selected, which show high binding affinity toward the ACE2 receptor.	Anidulafungin	29-42	angiotensin converting enzyme 2	Homo sapiens	129-133
35401674-4	2022	Three drug candidates (i.e., anidulafungin, lopinavir, and indinavir) were selected, which show high binding affinity toward the ACE2 receptor.	Lopinavir	44-53	angiotensin converting enzyme 2	Homo sapiens	129-133
35401674-4	2022	Three drug candidates (i.e., anidulafungin, lopinavir, and indinavir) were selected, which show high binding affinity toward the ACE2 receptor.	Indinavir	59-68	angiotensin converting enzyme 2	Homo sapiens	129-133
35401674-9	2022	Altogether, anidulafungin and lopinavir are ranked the most effective among all the tested drugs against ACE2 receptor-S glycoprotein interaction.	Anidulafungin	12-25	angiotensin converting enzyme 2	Homo sapiens	105-109
35401674-9	2022	Altogether, anidulafungin and lopinavir are ranked the most effective among all the tested drugs against ACE2 receptor-S glycoprotein interaction.	Lopinavir	30-39	angiotensin converting enzyme 2	Homo sapiens	105-109
35401674-10	2022	Based on these findings, we propose that anidulafungin is a novel potential drug targeting ACE2, which warrants further investigation for COVID-19 treatment.	Anidulafungin	41-54	angiotensin converting enzyme 2	Homo sapiens	91-95
35378747-0	2022	Repeated ethanol exposure and withdrawal alters ACE2 expression in discrete brain regions: Implications for SARS-CoV-2 infection.	Ethanol	9-16	angiotensin converting enzyme 2	Homo sapiens	48-52
35378747-3	2022	While ACE2 and TMPRSS2 genes are upregulated in the cortex of alcohol-dependent individuals, information on expression in specific brain regions and neural populations implicated in SARS-CoV-2 neuroinvasion, particularly monoaminergic neurons, is limited.	Alcohols	62-69	angiotensin converting enzyme 2	Homo sapiens	6-10
35378747-4	2022	We sought to clarify how chronic alcohol exposure affects ACE2 and TMPRSS2 expression in monoaminergic brainstem circuits and other putative SARS-CoV-2 entry points.	Alcohols	33-40	angiotensin converting enzyme 2	Homo sapiens	58-62
35424902-3	2022	Complete deactivation of spike protein binding to the human ACE2 protein was observed within an exposure time of 5 minutes which is correlated to the higher concentration of hydrogen peroxide formation due to the interaction with the reactive oxygen species present in the plasma.	Hydrogen Peroxide	174-191	angiotensin converting enzyme 2	Homo sapiens	60-64
35424902-3	2022	Complete deactivation of spike protein binding to the human ACE2 protein was observed within an exposure time of 5 minutes which is correlated to the higher concentration of hydrogen peroxide formation due to the interaction with the reactive oxygen species present in the plasma.	Oxygen	243-249	angiotensin converting enzyme 2	Homo sapiens	60-64
35331159-3	2022	METHODS: We investigated telmisartan, linagliptin and empagliflozin induced effects on renal and cardiac expression of ACE2, TMPRSS2 and key enzymes involved in RAAS (REN, AGTR2, AGT) under high-salt conditions in a non-diabetic experimental 5/6 nephrectomy (5/6 Nx) model.	Linagliptin	38-49	angiotensin converting enzyme 2	Homo sapiens	119-123
35331159-3	2022	METHODS: We investigated telmisartan, linagliptin and empagliflozin induced effects on renal and cardiac expression of ACE2, TMPRSS2 and key enzymes involved in RAAS (REN, AGTR2, AGT) under high-salt conditions in a non-diabetic experimental 5/6 nephrectomy (5/6 Nx) model.	empagliflozin	54-67	angiotensin converting enzyme 2	Homo sapiens	119-123
35391802-10	2022	In addition, we found that V739I variants of ACE2, which functions as the receptor for SARS-CoVs, were heterozygous in Vero JCRB0111, Vero CCL-81, and Vero 76; however, Vero E6 harbored only the allele with isoleucine, resulting from the loss of one of the X chromosomes.	Isoleucine	207-217	angiotensin converting enzyme 2	Homo sapiens	45-49
35402510-6	2022	Molecular docking results revealed that tustin could combine with ACE2 and NRP1 in stable structures, and their interacted regions cover the binding surfaces of S1-protein with the two receptors.	tustin	40-46	angiotensin converting enzyme 2	Homo sapiens	66-70
35401543-8	2022	Thus, we can hypothesize that CBD may counteract the inflammatory process of SARS-CoV-2 by its interactions with both ACE2 and the interplay between the WNT/beta-catenin pathway and PPARgamma.	Cannabidiol	30-33	angiotensin converting enzyme 2	Homo sapiens	118-122
35038454-8	2022	RBD-induced ACE2-GFP internalization was increased by angiotensin II and reduced by telmisartan in cells coexpressing AT1R.	Telmisartan	84-95	angiotensin converting enzyme 2	Homo sapiens	12-16
35408447-1	2022	The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its downregulation, which subsequently leads to the dysregulation of the renin-angiotensin system (RAS) in favor of the ACE-angiotensin II (Ang II)-angiotensin II type I receptor (AT1R) axis.	Angiotensin II	316-322	angiotensin converting enzyme 2	Homo sapiens	129-160
35408447-1	2022	The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its downregulation, which subsequently leads to the dysregulation of the renin-angiotensin system (RAS) in favor of the ACE-angiotensin II (Ang II)-angiotensin II type I receptor (AT1R) axis.	Angiotensin II	316-322	angiotensin converting enzyme 2	Homo sapiens	162-166
35328828-7	2022	More specifically, strong electrostatic interactions (salt bridges) and hydrogen bonding were observed between R493 and R498 residues of the Omicron RBD with D30/E35 and D38 residues of the hACE2, respectively.	Hydrogen	72-80	angiotensin converting enzyme 2	Homo sapiens	190-195
35328828-8	2022	Other mutated amino acids in the Omicron RBD, e.g., S496 and H505, also exhibited hydrogen bonding with the hACE2 receptor.	Hydrogen	82-90	angiotensin converting enzyme 2	Homo sapiens	108-113
35328828-9	2022	A pi-stacking interaction was also observed between tyrosine residues (RBD-Tyr501: hACE2-Tyr41) in the complex, which contributes majorly to the binding free energies and suggests that this is one of the key interactions stabilizing the formation of the complex.	Tyrosine	52-60	angiotensin converting enzyme 2	Homo sapiens	83-88
35437514-3	2022	We describe a bead-based screening assay for S1-neutralization using recombinant fluorescent proteins of hACE2 and SARS-CoV2-S1, immobilized on solid beads employing nanobodies/metal-affinity tags.	Metals	177-182	angiotensin converting enzyme 2	Homo sapiens	105-110
35437514-4	2022	Nanobody-mediated capture of SARS-CoV-2-Spike (S1) on agarose beads served as the trap for soluble recombinant ACE2-GFPSpark, inhibited by neutralizing antibody.	Sepharose	54-61	angiotensin converting enzyme 2	Homo sapiens	111-115
35437514-5	2022	The first approach demonstrates single-color fluorescent imaging of ACE2-GFPSpark binding to His-tagged S1-Receptor Binding Domain (RBD-His) immobilized beads.	Histidine	93-96	angiotensin converting enzyme 2	Homo sapiens	68-72
35313576-4	2022	ADG20 can then benefit from high potency through direct competition with ACE2 in the more variable RBS and interaction with the more highly conserved CR3022 site.	adg20	0-5	angiotensin converting enzyme 2	Homo sapiens	73-77
35401827-7	2022	Hydroxyl radical ( OH) and species derived from its interactions with other species were found to be the most effective CAP components for triggering ACE2 nucleus translocation.	Hydroxyl Radical	0-16	angiotensin converting enzyme 2	Homo sapiens	150-154
35372520-10	2022	The results showed that hydrogen bonds mediated the interactions between ACE2 glycans and S protein with desialylated glycans forming significantly fewer hydrogen bonds.	Hydrogen	24-32	angiotensin converting enzyme 2	Homo sapiens	73-77
35372520-10	2022	The results showed that hydrogen bonds mediated the interactions between ACE2 glycans and S protein with desialylated glycans forming significantly fewer hydrogen bonds.	Polysaccharides	78-85	angiotensin converting enzyme 2	Homo sapiens	73-77
35372520-10	2022	The results showed that hydrogen bonds mediated the interactions between ACE2 glycans and S protein with desialylated glycans forming significantly fewer hydrogen bonds.	Polysaccharides	118-125	angiotensin converting enzyme 2	Homo sapiens	73-77
35372520-10	2022	The results showed that hydrogen bonds mediated the interactions between ACE2 glycans and S protein with desialylated glycans forming significantly fewer hydrogen bonds.	Hydrogen	154-162	angiotensin converting enzyme 2	Homo sapiens	73-77
35372520-11	2022	These results supported a mechanism where the virus binds initially to glycans on host cells preferring alpha-(2,6)-sialic acids and finds ACE2 and with the proper orientation infects the cell.	Polysaccharides	71-78	angiotensin converting enzyme 2	Homo sapiens	139-143
35277472-2	2022	Here, we show AKT serine/threonine kinase-dependent epigenetic control of ACE2 and TMPRSS2 expression by high-cannabidiol (CBD) cannabis extracts and their individual components.	high-cannabidiol	105-121	angiotensin converting enzyme 2	Homo sapiens	74-78
35277472-2	2022	Here, we show AKT serine/threonine kinase-dependent epigenetic control of ACE2 and TMPRSS2 expression by high-cannabidiol (CBD) cannabis extracts and their individual components.	Serine	18-24	angiotensin converting enzyme 2	Homo sapiens	74-78
35329890-7	2022	Mechanistically, it has been proposed that hyperglycemia might be a disease-modifier for COVID-19 through multiple mechanisms: (a) induction of glycation and oligomerization of ACE2, the main receptor of SARS-CoV-2; (b) increased expression of the serine protease TMPRSS2, responsible for S protein priming; (c) impairment of the function of innate and adaptive immunity despite the induction of higher pro-inflammatory responses, both local and systemic.	Serine	248-254	angiotensin converting enzyme 2	Homo sapiens	177-181
35277472-2	2022	Here, we show AKT serine/threonine kinase-dependent epigenetic control of ACE2 and TMPRSS2 expression by high-cannabidiol (CBD) cannabis extracts and their individual components.	Cannabidiol	123-126	angiotensin converting enzyme 2	Homo sapiens	74-78
35277472-5	2022	CBD and terpene PTWT2.2 profoundly inhibited ACE2 and TMPRSS2 expression, both individually and in combination.	Cannabidiol	0-3	angiotensin converting enzyme 2	Homo sapiens	45-49
35277472-5	2022	CBD and terpene PTWT2.2 profoundly inhibited ACE2 and TMPRSS2 expression, both individually and in combination.	Terpenes	8-15	angiotensin converting enzyme 2	Homo sapiens	45-49
35270013-6	2022	The calculated bond order, based on AABPU, reveals that the Omicron mutations increase the binding strength of RBM to ACE2.	aabpu	36-41	angiotensin converting enzyme 2	Homo sapiens	118-122
35359831-0	2022	Oral Lisinopril Raises Tissue Levels of ACE2, the SARS-CoV-2 Receptor, in Healthy Male and Female Mice.	Lisinopril	5-15	angiotensin converting enzyme 2	Homo sapiens	40-44
35359831-2	2022	However, it is unclear whether ACE1 inhibitors (e.g., lisinopril) or angiotensin receptor blockers (e.g., losartan) alter tissue ACE2 expression.	Lisinopril	54-64	angiotensin converting enzyme 2	Homo sapiens	129-133
35359831-2	2022	However, it is unclear whether ACE1 inhibitors (e.g., lisinopril) or angiotensin receptor blockers (e.g., losartan) alter tissue ACE2 expression.	Losartan	106-114	angiotensin converting enzyme 2	Homo sapiens	129-133
35359831-12	2022	Oral lisinopril increases ACE2, the cellular receptor for SARS-CoV-2, in tissues that are relevant to the transmission and pathogenesis of COVID-19.	Lisinopril	5-15	angiotensin converting enzyme 2	Homo sapiens	26-30
35359831-13	2022	Remarkably, the addition of losartan prevented lisinopril-induced increases in ACE2 across tissues.	Losartan	28-36	angiotensin converting enzyme 2	Homo sapiens	79-83
35359831-13	2022	Remarkably, the addition of losartan prevented lisinopril-induced increases in ACE2 across tissues.	Lisinopril	47-57	angiotensin converting enzyme 2	Homo sapiens	79-83
35233569-4	2022	Mito-MES given in SARS-CoV-2 infected K18-hACE2 mice through oral gavage reduced viral titer by nearly 4 log units relative to the vehicle group.	mito-mes	0-8	angiotensin converting enzyme 2	Homo sapiens	42-47
35321335-4	2022	The computational analysis, considering the case in which all the lysine residues in the system are subjected to non-enzymatic glycation, confirmed that lysine glycation causes a general loss of interactivity between wild-type (WT)-Spike-RBD and ACE2.	Lysine	66-72	angiotensin converting enzyme 2	Homo sapiens	246-250
35321335-4	2022	The computational analysis, considering the case in which all the lysine residues in the system are subjected to non-enzymatic glycation, confirmed that lysine glycation causes a general loss of interactivity between wild-type (WT)-Spike-RBD and ACE2.	Lysine	153-159	angiotensin converting enzyme 2	Homo sapiens	246-250
35399958-4	2022	Results: Among the studied phytoligands, cannabigerolic acid (2), cannabigerol (8), and its acid methyl ether (3) possessed the highest binding affinities to SARS-CoV-hACE2 complex essential for viral entry.	phytoligands	27-39	angiotensin converting enzyme 2	Homo sapiens	167-172
35236774-3	2022	METHODS: A human soluble ACE2 variant fused with an albumin binding domain (ABD) was linked via a dimerization motif hinge-like 4-cysteine dodecapeptide (DDC) to improve binding capacity to SARS-CoV-2.	4-cysteine dodecapeptide	128-152	angiotensin converting enzyme 2	Homo sapiens	25-29
35236774-3	2022	METHODS: A human soluble ACE2 variant fused with an albumin binding domain (ABD) was linked via a dimerization motif hinge-like 4-cysteine dodecapeptide (DDC) to improve binding capacity to SARS-CoV-2.	Zalcitabine	154-157	angiotensin converting enzyme 2	Homo sapiens	25-29
35236774-6	2022	In contrast, all but one mouse infected with a lethal dose of SARS-CoV-2 that received ACE2-1-618-DDC-ABD survived.	ddc-abd	98-105	angiotensin converting enzyme 2	Homo sapiens	87-91
35133176-8	2022	JMB2002 binds to RBD differently from other characterized antibodies and inhibits ACE2 binding.	jmb2002	0-7	angiotensin converting enzyme 2	Homo sapiens	82-86
35240221-4	2022	Therefore, in this study, we present a novel therapeutic agent, SI-F019, an ACE2-Fc fusion protein whose neutralization efficiency is not compromised, but actually strengthened, by the mutations of dominant variants including Omicron.	si-f019	64-71	angiotensin converting enzyme 2	Homo sapiens	76-80
35150639-0	2022	Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry.	Imatinib Mesylate	0-8	angiotensin converting enzyme 2	Homo sapiens	93-97
35150639-0	2022	Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry.	Methazolamide	13-26	angiotensin converting enzyme 2	Homo sapiens	93-97
35150639-4	2022	By using structure-based high-throughput virtual screening and connectivity map database, followed with experimental validations, we identify imatinib, methazolamide, and harpagoside as direct enzymatic activators of ACE2.	Imatinib Mesylate	142-150	angiotensin converting enzyme 2	Homo sapiens	217-221
35150639-4	2022	By using structure-based high-throughput virtual screening and connectivity map database, followed with experimental validations, we identify imatinib, methazolamide, and harpagoside as direct enzymatic activators of ACE2.	Methazolamide	152-165	angiotensin converting enzyme 2	Homo sapiens	217-221
35150639-4	2022	By using structure-based high-throughput virtual screening and connectivity map database, followed with experimental validations, we identify imatinib, methazolamide, and harpagoside as direct enzymatic activators of ACE2.	harpagoside	171-182	angiotensin converting enzyme 2	Homo sapiens	217-221
35150639-5	2022	Imatinib and methazolamide remarkably improve metabolic perturbations in vivo in an ACE2-dependent manner under the insulin-resistant state and SARS-CoV-2-infected state.	Imatinib Mesylate	0-8	angiotensin converting enzyme 2	Homo sapiens	84-88
35150639-5	2022	Imatinib and methazolamide remarkably improve metabolic perturbations in vivo in an ACE2-dependent manner under the insulin-resistant state and SARS-CoV-2-infected state.	Methazolamide	13-26	angiotensin converting enzyme 2	Homo sapiens	84-88
35150639-7	2022	Taken together, our study shows that enzymatic activation of ACE2 via imatinib, methazolamide, or harpagoside may be a conceptually new strategy to treat metabolic sequelae of COVID-19.	Imatinib Mesylate	70-78	angiotensin converting enzyme 2	Homo sapiens	61-65
35150639-7	2022	Taken together, our study shows that enzymatic activation of ACE2 via imatinib, methazolamide, or harpagoside may be a conceptually new strategy to treat metabolic sequelae of COVID-19.	Methazolamide	80-93	angiotensin converting enzyme 2	Homo sapiens	61-65
35150639-7	2022	Taken together, our study shows that enzymatic activation of ACE2 via imatinib, methazolamide, or harpagoside may be a conceptually new strategy to treat metabolic sequelae of COVID-19.	harpagoside	98-109	angiotensin converting enzyme 2	Homo sapiens	61-65
35399958-4	2022	Results: Among the studied phytoligands, cannabigerolic acid (2), cannabigerol (8), and its acid methyl ether (3) possessed the highest binding affinities to SARS-CoV-hACE2 complex essential for viral entry.	cannabigerolic acid	41-60	angiotensin converting enzyme 2	Homo sapiens	167-172
35399958-4	2022	Results: Among the studied phytoligands, cannabigerolic acid (2), cannabigerol (8), and its acid methyl ether (3) possessed the highest binding affinities to SARS-CoV-hACE2 complex essential for viral entry.	cannabigerol	66-78	angiotensin converting enzyme 2	Homo sapiens	167-172
35399958-4	2022	Results: Among the studied phytoligands, cannabigerolic acid (2), cannabigerol (8), and its acid methyl ether (3) possessed the highest binding affinities to SARS-CoV-hACE2 complex essential for viral entry.	acid methyl ether	92-109	angiotensin converting enzyme 2	Homo sapiens	167-172
34861788-9	2022	Administration of ACE2 enzyme activator diminazene aceturate intraperitoneally rescued downregulation of ACE2 enzymatic activity and protein abundance in the brain.	diminazene aceturate	40-60	angiotensin converting enzyme 2	Homo sapiens	18-22
34862332-2	2022	Angiotensin-converting enzyme-2 (ACE2) is the receptor responsible for coronavirus binding, while subsequent cell entry relies on priming by the serine protease TMPRSS2 (transmembrane protease, serine 2).	Serine	145-151	angiotensin converting enzyme 2	Homo sapiens	33-37
34862332-2	2022	Angiotensin-converting enzyme-2 (ACE2) is the receptor responsible for coronavirus binding, while subsequent cell entry relies on priming by the serine protease TMPRSS2 (transmembrane protease, serine 2).	Serine	194-200	angiotensin converting enzyme 2	Homo sapiens	33-37
34862332-3	2022	Although renin-angiotensin-aldosterone-system (RAAS) blockers have been suggested to upregulate ACE2, their use in COVID-19 patients is now considered well tolerated.	Aldosterone	27-38	angiotensin converting enzyme 2	Homo sapiens	96-100
35046573-3	2022	Several mAbs (LY-CoV555, LY-CoV016, REGN10933, REGN10987 and CT-P59) completely lost neutralizing activity against B.1.1.529 virus in both Vero-TMPRSS2 and Vero-hACE2-TMPRSS2 cells, whereas others were reduced (COV2-2196 and COV2-2130 combination, ~12-fold decrease) or minimally affected (S309).	Lysine	14-16	angiotensin converting enzyme 2	Homo sapiens	161-166
35382132-8	2022	Conclusion: EGCG can be a potential inhibitor drug which can bind with ACE-2 receptor thus inhibiting the interaction of mainly Mpro protein and spike glycoprotein of SARS-CoV-2.	epigallocatechin gallate	12-16	angiotensin converting enzyme 2	Homo sapiens	71-76
34861788-9	2022	Administration of ACE2 enzyme activator diminazene aceturate intraperitoneally rescued downregulation of ACE2 enzymatic activity and protein abundance in the brain.	diminazene aceturate	40-60	angiotensin converting enzyme 2	Homo sapiens	105-109
35295301-13	2022	The docking results suggest that the key residues K353 and G496 may affect the binding energies and dynamics between the inferred anti-SARS-CoV-2 chemical agents and the junction of the spike protein-ACE2 interface.	Fluoroglycofen	50-54	angiotensin converting enzyme 2	Homo sapiens	200-204
35475273-8	2022	Conclusion: EGCG can be a potential inhibitor drug which can bind with ACE-2 receptor thus inhibiting the interaction of mainly Mpro protein and spike glycoprotein of SARS-CoV-2.	epigallocatechin gallate	12-16	angiotensin converting enzyme 2	Homo sapiens	71-76
35295301-13	2022	The docking results suggest that the key residues K353 and G496 may affect the binding energies and dynamics between the inferred anti-SARS-CoV-2 chemical agents and the junction of the spike protein-ACE2 interface.	g496	59-63	angiotensin converting enzyme 2	Homo sapiens	200-204
35203711-7	2022	An initial suggestion that the susceptibility to infection and disease severity may be enhanced by angiotensin type-1 receptor blockers (ARBs) and ACE inhibitors (ACEIs) because they increase ACE2 levels, led to the consideration of discontinuing treatments in thousands of patients.	angiotensin type-1 receptor blockers	99-135	angiotensin converting enzyme 2	Homo sapiens	192-196
35226423-8	2022	Blood eosinophils and fractionated exhaled nitric oxide levels were positively correlated with serum ACE2.	Nitric Oxide	43-55	angiotensin converting enzyme 2	Homo sapiens	101-105
35269785-3	2022	Previously, we showed that the phenolic compounds corilagin and 1,3,6-tri-O-galloyl-beta-D-glucose (TGG) inhibit the interaction between the SARS-CoV-2 spike protein receptor binding domain (RBD) and angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 target receptor on the cell membrane of the host organism.	corilagin	50-59	angiotensin converting enzyme 2	Homo sapiens	200-231
35269785-3	2022	Previously, we showed that the phenolic compounds corilagin and 1,3,6-tri-O-galloyl-beta-D-glucose (TGG) inhibit the interaction between the SARS-CoV-2 spike protein receptor binding domain (RBD) and angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 target receptor on the cell membrane of the host organism.	corilagin	50-59	angiotensin converting enzyme 2	Homo sapiens	233-237
35269785-3	2022	Previously, we showed that the phenolic compounds corilagin and 1,3,6-tri-O-galloyl-beta-D-glucose (TGG) inhibit the interaction between the SARS-CoV-2 spike protein receptor binding domain (RBD) and angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 target receptor on the cell membrane of the host organism.	Glucose	91-98	angiotensin converting enzyme 2	Homo sapiens	200-231
35269785-3	2022	Previously, we showed that the phenolic compounds corilagin and 1,3,6-tri-O-galloyl-beta-D-glucose (TGG) inhibit the interaction between the SARS-CoV-2 spike protein receptor binding domain (RBD) and angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 target receptor on the cell membrane of the host organism.	Glucose	91-98	angiotensin converting enzyme 2	Homo sapiens	233-237
35269785-3	2022	Previously, we showed that the phenolic compounds corilagin and 1,3,6-tri-O-galloyl-beta-D-glucose (TGG) inhibit the interaction between the SARS-CoV-2 spike protein receptor binding domain (RBD) and angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 target receptor on the cell membrane of the host organism.	1,3,6-tri-O-galloylglucose	100-103	angiotensin converting enzyme 2	Homo sapiens	200-231
35269785-3	2022	Previously, we showed that the phenolic compounds corilagin and 1,3,6-tri-O-galloyl-beta-D-glucose (TGG) inhibit the interaction between the SARS-CoV-2 spike protein receptor binding domain (RBD) and angiotensin-converting enzyme 2 (ACE2), the SARS-CoV-2 target receptor on the cell membrane of the host organism.	1,3,6-tri-O-galloylglucose	100-103	angiotensin converting enzyme 2	Homo sapiens	233-237
35269785-6	2022	In this work, a combination of experimental methods (biochemical inhibition assays, surface plasmon resonance, and quartz crystal microbalance with dissipation monitoring) confirms the potential role of TA in the prevention of SARS-CoV-2 infectivity through the inhibition of extracellular RBD/ACE2 interactions and TMPRSS2 and 3CLpro activity.	Tannins	203-205	angiotensin converting enzyme 2	Homo sapiens	294-298
35252734-0	2022	Blocking SARS-CoV-2 Delta Variant (B.1.617.2) Spike Protein Receptor-Binding Domain Binding with the ACE2 Receptor of the Host Cell and Inhibiting Virus Infections Using Human Host Defense Peptide-Conjugated Graphene Quantum Dots.	Graphite	208-216	angiotensin converting enzyme 2	Homo sapiens	101-105
35252734-3	2022	Herein, we report for the first time that human host defense neutrophil alpha-defensin HNP1 and human cathelicidin LL-37 peptide-conjugated graphene quantum dots (GQDs) have the capability to prevent the delta variant virus entry into the host cells via blocking SARS-CoV-2 delta variant (B.1.617.2) spike protein receptor-binding domain (RBD) binding with host cells" angiotensin converting enzyme 2 (ACE2).	Peptides	121-128	angiotensin converting enzyme 2	Homo sapiens	369-400
35252734-3	2022	Herein, we report for the first time that human host defense neutrophil alpha-defensin HNP1 and human cathelicidin LL-37 peptide-conjugated graphene quantum dots (GQDs) have the capability to prevent the delta variant virus entry into the host cells via blocking SARS-CoV-2 delta variant (B.1.617.2) spike protein receptor-binding domain (RBD) binding with host cells" angiotensin converting enzyme 2 (ACE2).	Peptides	121-128	angiotensin converting enzyme 2	Homo sapiens	402-406
35252734-3	2022	Herein, we report for the first time that human host defense neutrophil alpha-defensin HNP1 and human cathelicidin LL-37 peptide-conjugated graphene quantum dots (GQDs) have the capability to prevent the delta variant virus entry into the host cells via blocking SARS-CoV-2 delta variant (B.1.617.2) spike protein receptor-binding domain (RBD) binding with host cells" angiotensin converting enzyme 2 (ACE2).	Graphite	140-148	angiotensin converting enzyme 2	Homo sapiens	369-400
35252734-3	2022	Herein, we report for the first time that human host defense neutrophil alpha-defensin HNP1 and human cathelicidin LL-37 peptide-conjugated graphene quantum dots (GQDs) have the capability to prevent the delta variant virus entry into the host cells via blocking SARS-CoV-2 delta variant (B.1.617.2) spike protein receptor-binding domain (RBD) binding with host cells" angiotensin converting enzyme 2 (ACE2).	Graphite	140-148	angiotensin converting enzyme 2	Homo sapiens	402-406
35220925-0	2022	Inhibitory mechanism of clioquinol and its derivatives at the exopeptidase site of human angiotensin-converting enzyme-2 and receptor binding domain of SARS-CoV-2 viral spike.	Clioquinol	24-34	angiotensin converting enzyme 2	Homo sapiens	89-120
35220925-2	2022	This study focused on investigating the mechanism of inhibition of clioquinol (CLQ) and its derivatives (7-bromo-5-chloro-8-hydroxyquinoline (CLBQ), 5, 7-Dichloro-8-hydroxyquinoline (CLCQ)) against the viral glycoprotein, and human angiotensin-converting enzyme-2 (hACE-2) involved in SARS-CoV-2 entry.	7-Bromo-5-chloroquinolin-8-ol	105-140	angiotensin converting enzyme 2	Homo sapiens	232-263
35220925-2	2022	This study focused on investigating the mechanism of inhibition of clioquinol (CLQ) and its derivatives (7-bromo-5-chloro-8-hydroxyquinoline (CLBQ), 5, 7-Dichloro-8-hydroxyquinoline (CLCQ)) against the viral glycoprotein, and human angiotensin-converting enzyme-2 (hACE-2) involved in SARS-CoV-2 entry.	7-Bromo-5-chloroquinolin-8-ol	105-140	angiotensin converting enzyme 2	Homo sapiens	265-271
35220925-5	2022	Evaluation of the binding energies of the drugs to hACE-2 after 100 ns MD simulations revealed CLQ to have the highest binding energy value of -40.4 kcal/mol close to MLN-7640 (-45.4 kcal/mol), and higher than the exhibited values for its derivatives: CLBQ (-34.5 kcal/mol) and CLCQ (-24.8 kcal/mol).	clbq	252-256	angiotensin converting enzyme 2	Homo sapiens	51-57
35220926-8	2022	Molecular dynamics simulations verified that imatinib interacts with RBD residues that are critical for ACE2 binding.	Imatinib Mesylate	45-53	angiotensin converting enzyme 2	Homo sapiens	104-108
35171037-9	2022	The detachment of the SARS-CoV-2 receptor-binding domain from hACE2 increased as the BE concentration increased, allowing the release of the virus from hACE2 for early diagnosis.	Beryllium	85-87	angiotensin converting enzyme 2	Homo sapiens	62-67
35171037-9	2022	The detachment of the SARS-CoV-2 receptor-binding domain from hACE2 increased as the BE concentration increased, allowing the release of the virus from hACE2 for early diagnosis.	Beryllium	85-87	angiotensin converting enzyme 2	Homo sapiens	152-157
35203711-7	2022	An initial suggestion that the susceptibility to infection and disease severity may be enhanced by angiotensin type-1 receptor blockers (ARBs) and ACE inhibitors (ACEIs) because they increase ACE2 levels, led to the consideration of discontinuing treatments in thousands of patients.	arbs	137-141	angiotensin converting enzyme 2	Homo sapiens	192-196
35106453-4	2022	Losartan, an angiotensin II receptor blocker being tested in COVID-19 patients, inhibited angiotensin II mediated internalization of ACE2, upregulated interferon stimulated genes (IFITM1 and BST2) known to restrict viral entry, and attenuated the infection of proximal tubule cells by SARS-CoV-2.	Losartan	0-8	angiotensin converting enzyme 2	Homo sapiens	133-137
35216194-7	2022	Although this class of nAbs only partially inhibits the spike protein binding to the host"s angiotensin converting enzyme 2 (ACE2), it has been suggested to lock the closed pre-fusion spike protein conformation and therefore prevent its transition to an open state.	nabs	23-27	angiotensin converting enzyme 2	Homo sapiens	92-123
35157239-7	2022	Out of selected phytoconstituents, vicenin 2, rosmarinic acid, and orientin were found to have the highest efficacy in terms of molecular interaction and drug-likeness properties against ACE2 and TMPRSS2 host receptor proteins.	rosmarinic acid	46-61	angiotensin converting enzyme 2	Homo sapiens	187-191
35251001-5	2022	We found that treatment with simvastatin significantly reduced the viral replication and lung damage in vivo, delaying SARS-CoV-2-associated physiopathology and mortality in the K18-hACE2-transgenic mice model.	Simvastatin	29-40	angiotensin converting enzyme 2	Homo sapiens	182-187
35251001-7	2022	Additionally, we also observed that simvastatin affected the course of SARS-CoV-2 infection through displacing ACE2 on cell membrane lipid rafts.	Simvastatin	36-47	angiotensin converting enzyme 2	Homo sapiens	111-115
35200677-0	2022	In Silico Screening of Bioactive Compounds of Representative Seaweeds to Inhibit SARS-CoV-2 ACE2-Bound Omicron B.1.1.529 Spike Protein Trimer.	omicron b	103-112	angiotensin converting enzyme 2	Homo sapiens	92-96
35200677-9	2022	Our molecular docking analysis revealed that caffeic acid hexoside (-6.4 kcal/mol; RMSD = 2.382 A) and phloretin (-6.3 kcal/mol; RMSD = 0.061 A) from Sargassum wightii (S. wightii) showed the inhibitory effect against the crucial residues ASN417, SER496, TYR501, and HIS505, which are supported for the inviolable omicron and angiotensin-converting enzyme II (ACE2) receptor interaction.	1-o-caffeoylglucose	45-66	angiotensin converting enzyme 2	Homo sapiens	360-364
35200677-9	2022	Our molecular docking analysis revealed that caffeic acid hexoside (-6.4 kcal/mol; RMSD = 2.382 A) and phloretin (-6.3 kcal/mol; RMSD = 0.061 A) from Sargassum wightii (S. wightii) showed the inhibitory effect against the crucial residues ASN417, SER496, TYR501, and HIS505, which are supported for the inviolable omicron and angiotensin-converting enzyme II (ACE2) receptor interaction.	Phloretin	103-112	angiotensin converting enzyme 2	Homo sapiens	360-364
35060381-1	2022	The viral entry process of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires heparin and heparan sulfates from the cell surface, functioning as a cofactor for human angiotensin-converting enzyme 2 (ACE2) for recognizing the receptor-binding domain (RBD) of the spike (S) protein on the surface of the virion.	Heparin	107-114	angiotensin converting enzyme 2	Homo sapiens	195-226
35060381-1	2022	The viral entry process of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires heparin and heparan sulfates from the cell surface, functioning as a cofactor for human angiotensin-converting enzyme 2 (ACE2) for recognizing the receptor-binding domain (RBD) of the spike (S) protein on the surface of the virion.	Heparin	107-114	angiotensin converting enzyme 2	Homo sapiens	228-232
35060381-1	2022	The viral entry process of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires heparin and heparan sulfates from the cell surface, functioning as a cofactor for human angiotensin-converting enzyme 2 (ACE2) for recognizing the receptor-binding domain (RBD) of the spike (S) protein on the surface of the virion.	Heparitin Sulfate	119-135	angiotensin converting enzyme 2	Homo sapiens	195-226
35060381-1	2022	The viral entry process of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires heparin and heparan sulfates from the cell surface, functioning as a cofactor for human angiotensin-converting enzyme 2 (ACE2) for recognizing the receptor-binding domain (RBD) of the spike (S) protein on the surface of the virion.	Heparitin Sulfate	119-135	angiotensin converting enzyme 2	Homo sapiens	228-232
35060381-5	2022	The comparisons with the ACE2-RBD complex suggested that the presence of octa in the RBD binding site blocked the movements in a loop region at the distal end of the RBD binding interface and promoted the contacts of this loop region with the ACE2 N-terminus helix.	CDTA	73-77	angiotensin converting enzyme 2	Homo sapiens	25-29
35060381-5	2022	The comparisons with the ACE2-RBD complex suggested that the presence of octa in the RBD binding site blocked the movements in a loop region at the distal end of the RBD binding interface and promoted the contacts of this loop region with the ACE2 N-terminus helix.	CDTA	73-77	angiotensin converting enzyme 2	Homo sapiens	243-247
35216194-7	2022	Although this class of nAbs only partially inhibits the spike protein binding to the host"s angiotensin converting enzyme 2 (ACE2), it has been suggested to lock the closed pre-fusion spike protein conformation and therefore prevent its transition to an open state.	nabs	23-27	angiotensin converting enzyme 2	Homo sapiens	125-129
35157175-0	2022	Citrus fruits are rich in flavonoids for immunoregulation and potential targeting ACE2.	Flavonoids	26-36	angiotensin converting enzyme 2	Homo sapiens	82-86
35215921-7	2022	Additionally, 6-sulfo N-acetyllactosamine was found to inhibit the binding of the spike protein S1 subunit with blood group A RBCs and reduce the interaction between the spike protein S1 subunit and ACE2.	6-sulfo-LacNac	14-41	angiotensin converting enzyme 2	Homo sapiens	199-203
35215181-6	2022	Three independent 100 ns molecular dynamics (MD) simulations were performed using NAMD to investigate the hydrogen bonds between S proteins RBD and hACE2 RBD.	Hydrogen	106-114	angiotensin converting enzyme 2	Homo sapiens	148-153
35215181-7	2022	From MD simulations, we found that SARS-CoV-2 forms 19 pairs (average of three simulations) of hydrogen bonds with high occupancy (>50%) to hACE2, compared to 16 pairs between SARS-CoV and hACE2.	Hydrogen	95-103	angiotensin converting enzyme 2	Homo sapiens	140-145
35215181-7	2022	From MD simulations, we found that SARS-CoV-2 forms 19 pairs (average of three simulations) of hydrogen bonds with high occupancy (>50%) to hACE2, compared to 16 pairs between SARS-CoV and hACE2.	Hydrogen	95-103	angiotensin converting enzyme 2	Homo sapiens	189-194
35138508-4	2022	The simulation results indicated that there were differences in the interactions between the RBD and hACE2, including hydrogen bonding, salt bridge interactions, non-bonded interactions, and binding free energy differences among these variants.	Hydrogen	118-126	angiotensin converting enzyme 2	Homo sapiens	101-106
35118864-7	2022	The current study increases our understanding of ACE inhibition by MLN-4760 and how it modulates the conformational properties of ACE2.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	67-75	angiotensin converting enzyme 2	Homo sapiens	130-134
35173799-3	2022	Numerous studies have elucidated the presence of many components of the renin-angiotensin-aldosterone system (RAAS) in the eye, including the ACE2 receptor.	Aldosterone	90-101	angiotensin converting enzyme 2	Homo sapiens	142-146
35103351-0	2022	Estradiol reduces ACE2 and TMPRSS2 mRNA levels in A549 human lung epithelial cells.	Estradiol	0-9	angiotensin converting enzyme 2	Homo sapiens	18-22
35132950-6	2022	We found that the most promising candidates, namely, ZINC95628821, ZINC95617623, ZINC3979524, and ZINC261494658, strongly bind to the spike RBD and interfere with the human ACE2 receptor.	zinc95628821	53-65	angiotensin converting enzyme 2	Homo sapiens	173-177
35132950-6	2022	We found that the most promising candidates, namely, ZINC95628821, ZINC95617623, ZINC3979524, and ZINC261494658, strongly bind to the spike RBD and interfere with the human ACE2 receptor.	zinc95617623	67-79	angiotensin converting enzyme 2	Homo sapiens	173-177
35132950-6	2022	We found that the most promising candidates, namely, ZINC95628821, ZINC95617623, ZINC3979524, and ZINC261494658, strongly bind to the spike RBD and interfere with the human ACE2 receptor.	ZINC3979524	81-92	angiotensin converting enzyme 2	Homo sapiens	173-177
35132950-6	2022	We found that the most promising candidates, namely, ZINC95628821, ZINC95617623, ZINC3979524, and ZINC261494658, strongly bind to the spike RBD and interfere with the human ACE2 receptor.	zinc261494658	98-111	angiotensin converting enzyme 2	Homo sapiens	173-177
35215911-9	2022	We hypothesize that ferristatin II blocks the TfR1-mediated SARS-CoV-2 host cell entry; however, further studies are needed to elucidate the full mechanisms of this virus inhibition, including the effect of ferristatin II on other SARS-CoV-2 receptors, such as ACE2, Neuropilin-1 and CD147.	ferristatin II	20-34	angiotensin converting enzyme 2	Homo sapiens	261-265
34983944-0	2022	SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages.	Cholesterol	101-112	angiotensin converting enzyme 2	Homo sapiens	40-44
35103351-6	2022	Treatment of A549 human lung epithelial cells with 17-beta-estradiol reduced the cellular mRNA levels of ACE2 and TMPRSS2 mRNA, while not affecting FURIN expression.	Estradiol	51-68	angiotensin converting enzyme 2	Homo sapiens	105-109
35103351-8	2022	Studies into the molecular pathways by which 17-beta-estradiol reduces ACE2 and TMPRSS2 mRNA expression in lung epithelial cells are needed for assessing its potential protective value against severe Covid-19.	Estradiol	45-62	angiotensin converting enzyme 2	Homo sapiens	71-75
34849936-0	2022	Mesalamine Reduces Intestinal ACE2 Expression Without Modifying SARS-CoV-2 Infection or Disease Severity in Mice.	Mesalamine	0-10	angiotensin converting enzyme 2	Homo sapiens	30-34
35123263-3	2022	The cysteine residue at position 488, consisting of a disulfide bridge with cysteine 480 is located in an important structural loop at ACE2-binding surface of RBD, and is highly conserved among SARS-related coronaviruses.	Cysteine	76-84	angiotensin converting enzyme 2	Homo sapiens	135-139
35393089-1	2022	BACKGROUND: SARS-CoV-2 uses Angiotensin-Converting Enzyme 2 as a viral gateway to the cell and could interact with the renin-angiotensin-aldosterone system.	Aldosterone	137-148	angiotensin converting enzyme 2	Homo sapiens	28-59
35215242-0	2022	Antiviral Effects of Artemisinin and Its Derivatives against SARS-CoV-2 Main Protease: Computational Evidences and Interactions with ACE2 Allelic Variants.	artemisinin	21-32	angiotensin converting enzyme 2	Homo sapiens	133-137
35123263-3	2022	The cysteine residue at position 488, consisting of a disulfide bridge with cysteine 480 is located in an important structural loop at ACE2-binding surface of RBD, and is highly conserved among SARS-related coronaviruses.	Disulfides	54-63	angiotensin converting enzyme 2	Homo sapiens	135-139
35215242-8	2022	Furthermore, artemisinin interactions with angiotensin converting enzyme 2 (ACE2) were dependent on the ACE2 allelic variants.	artemisinin	13-24	angiotensin converting enzyme 2	Homo sapiens	43-74
35215242-8	2022	Furthermore, artemisinin interactions with angiotensin converting enzyme 2 (ACE2) were dependent on the ACE2 allelic variants.	artemisinin	13-24	angiotensin converting enzyme 2	Homo sapiens	76-80
35215242-8	2022	Furthermore, artemisinin interactions with angiotensin converting enzyme 2 (ACE2) were dependent on the ACE2 allelic variants.	artemisinin	13-24	angiotensin converting enzyme 2	Homo sapiens	104-108
35118120-5	2021	The resulting offspring with temporal control of transgene expression were treated with tamoxifen to induce the removal of the floxed STOP cassette, which prevented hACE2 expression.	Tamoxifen	88-97	angiotensin converting enzyme 2	Homo sapiens	165-170
35060921-4	2022	The composition containing vitamin C, N-acetylcysteine, resveratrol, theaflavin, curcumin, quercetin, naringenin, baicalin, and broccoli extract demonstrated a highest efficacy by inhibiting the receptor-binding domain (RBD) binding of SARS-CoV-2 to its cellular ACE2 receptor by 90%.	Quercetin	91-100	angiotensin converting enzyme 2	Homo sapiens	263-267
35060921-4	2022	The composition containing vitamin C, N-acetylcysteine, resveratrol, theaflavin, curcumin, quercetin, naringenin, baicalin, and broccoli extract demonstrated a highest efficacy by inhibiting the receptor-binding domain (RBD) binding of SARS-CoV-2 to its cellular ACE2 receptor by 90%.	naringenin	102-112	angiotensin converting enzyme 2	Homo sapiens	263-267
35060921-4	2022	The composition containing vitamin C, N-acetylcysteine, resveratrol, theaflavin, curcumin, quercetin, naringenin, baicalin, and broccoli extract demonstrated a highest efficacy by inhibiting the receptor-binding domain (RBD) binding of SARS-CoV-2 to its cellular ACE2 receptor by 90%.	baicalin	114-122	angiotensin converting enzyme 2	Homo sapiens	263-267
35060921-4	2022	The composition containing vitamin C, N-acetylcysteine, resveratrol, theaflavin, curcumin, quercetin, naringenin, baicalin, and broccoli extract demonstrated a highest efficacy by inhibiting the receptor-binding domain (RBD) binding of SARS-CoV-2 to its cellular ACE2 receptor by 90%.	broccoli extract	128-144	angiotensin converting enzyme 2	Homo sapiens	263-267
35005526-4	2022	The enhanced infectivity of 614G variant was higher than that of 614D wildtype in the presence of antibodies, further suggesting that ADE may be influenced by virus strains with different ACE2 binding affinity.	Adenine	134-137	angiotensin converting enzyme 2	Homo sapiens	188-192
35005526-5	2022	Finally, knockdown of ACE2 or treatment with a fusion-inhibition peptide EK1C4 significantly reduced ADE.	Adenine	101-104	angiotensin converting enzyme 2	Homo sapiens	22-26
35127768-9	2021	Among 9 compounds with the highest frequency of occurrence in the 9 prescriptions, baicalein had the highest ACE2 binding affinity and can be well-combined into the active pocket of ACE2 It is stabilized by forming hydrogen bonds with ASN290 and ILE291 in ACE2 and hydrophobic interaction with PHE438, ILE291, and PRO415.	baicalein	83-92	angiotensin converting enzyme 2	Homo sapiens	109-113
35127768-9	2021	Among 9 compounds with the highest frequency of occurrence in the 9 prescriptions, baicalein had the highest ACE2 binding affinity and can be well-combined into the active pocket of ACE2 It is stabilized by forming hydrogen bonds with ASN290 and ILE291 in ACE2 and hydrophobic interaction with PHE438, ILE291, and PRO415.	baicalein	83-92	angiotensin converting enzyme 2	Homo sapiens	182-186
35127768-9	2021	Among 9 compounds with the highest frequency of occurrence in the 9 prescriptions, baicalein had the highest ACE2 binding affinity and can be well-combined into the active pocket of ACE2 It is stabilized by forming hydrogen bonds with ASN290 and ILE291 in ACE2 and hydrophobic interaction with PHE438, ILE291, and PRO415.	baicalein	83-92	angiotensin converting enzyme 2	Homo sapiens	256-260
35127768-9	2021	Among 9 compounds with the highest frequency of occurrence in the 9 prescriptions, baicalein had the highest ACE2 binding affinity and can be well-combined into the active pocket of ACE2 It is stabilized by forming hydrogen bonds with ASN290 and ILE291 in ACE2 and hydrophobic interaction with PHE438, ILE291, and PRO415.	Hydrogen	215-223	angiotensin converting enzyme 2	Homo sapiens	182-186
35164065-3	2022	Analysis of the three-dimensional reference interaction site model (3DRISM) of SDFT indicates that water mediated interactions in the form of additional water bridges strongly increases the binding between SARS-CoV-2 spike protein and hACE2 compared to SARS-CoV-1-hACE2 complex.	Water	99-104	angiotensin converting enzyme 2	Homo sapiens	235-240
35164065-3	2022	Analysis of the three-dimensional reference interaction site model (3DRISM) of SDFT indicates that water mediated interactions in the form of additional water bridges strongly increases the binding between SARS-CoV-2 spike protein and hACE2 compared to SARS-CoV-1-hACE2 complex.	Water	99-104	angiotensin converting enzyme 2	Homo sapiens	264-269
35164065-3	2022	Analysis of the three-dimensional reference interaction site model (3DRISM) of SDFT indicates that water mediated interactions in the form of additional water bridges strongly increases the binding between SARS-CoV-2 spike protein and hACE2 compared to SARS-CoV-1-hACE2 complex.	Water	153-158	angiotensin converting enzyme 2	Homo sapiens	235-240
35164065-3	2022	Analysis of the three-dimensional reference interaction site model (3DRISM) of SDFT indicates that water mediated interactions in the form of additional water bridges strongly increases the binding between SARS-CoV-2 spike protein and hACE2 compared to SARS-CoV-1-hACE2 complex.	Water	153-158	angiotensin converting enzyme 2	Homo sapiens	264-269
35164065-6	2022	Further interface analysis has shown that interfacial water promotes and stabilizes the formation of CoV-2/hACE2 complex.	Water	54-59	angiotensin converting enzyme 2	Homo sapiens	107-112
35058437-6	2022	Consistently, evACE2 protects the hACE2 transgenic mice from SARS-CoV-2-induced lung injury and mortality.	evace2	14-20	angiotensin converting enzyme 2	Homo sapiens	34-39
35162972-2	2022	Early in the pandemic, there was speculation that a number of commonly used medications-including ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs)-have the potential to upregulate ACE2, thereby possibly facilitating viral entry and increasing the severity of COVID-19.	Ibuprofen	98-107	angiotensin converting enzyme 2	Homo sapiens	198-202
35215785-3	2022	In this study, we aimed at evaluating the therapeutic effect of a single intranasal treatment of the TLR3/MDA5 synthetic agonist Poly(I:C) against a lethal dose of SARS-CoV-2 in K18-hACE2 transgenic mice.	Poly I-C	129-138	angiotensin converting enzyme 2	Homo sapiens	182-187
34983356-9	2022	Metformin and statins through immunomodulatory activities, Orlistat by reducing viral replication, and thiazolidinediones by upregulating ACE2 expression have potential beneficial effects against COVID-19.	Metformin	0-9	angiotensin converting enzyme 2	Homo sapiens	138-142
34997794-2	2022	Published data revealed associations of COVID-19 susceptibility and severity with host genetic polymorphisms in renin-angiotensin-aldosterone system (RAAS)-related genes including angiotensin-converting enzyme (ACE)1, ACE2, and transmembrane protease (TMPRSS)2.	Aldosterone	130-141	angiotensin converting enzyme 2	Homo sapiens	218-222
35096642-5	2021	ACE2 sheds from the membrane, producing soluble ACE2 (sACE2).	sace2	54-59	angiotensin converting enzyme 2	Homo sapiens	0-4
35096642-5	2021	ACE2 sheds from the membrane, producing soluble ACE2 (sACE2).	sace2	54-59	angiotensin converting enzyme 2	Homo sapiens	48-52
35057501-6	2022	SARS-CoV-2 binding with ACE-2 causes depletion of ACE-2 (angiotensin-converting enzyme 2) from blood vessels, and subsequently, angiotensin-II interacts with angiotensin receptor-1 from vascular membranes that produce NADPH (nicotinamide adenine dinucleotide hydrogen phosphate) oxidase, oxidative stress, and constriction of blood vessels.	NADP	218-223	angiotensin converting enzyme 2	Homo sapiens	24-29
35057501-6	2022	SARS-CoV-2 binding with ACE-2 causes depletion of ACE-2 (angiotensin-converting enzyme 2) from blood vessels, and subsequently, angiotensin-II interacts with angiotensin receptor-1 from vascular membranes that produce NADPH (nicotinamide adenine dinucleotide hydrogen phosphate) oxidase, oxidative stress, and constriction of blood vessels.	NADP	218-223	angiotensin converting enzyme 2	Homo sapiens	50-55
35057501-6	2022	SARS-CoV-2 binding with ACE-2 causes depletion of ACE-2 (angiotensin-converting enzyme 2) from blood vessels, and subsequently, angiotensin-II interacts with angiotensin receptor-1 from vascular membranes that produce NADPH (nicotinamide adenine dinucleotide hydrogen phosphate) oxidase, oxidative stress, and constriction of blood vessels.	nicotinamide adenine dinucleotide hydrogen phosphate	225-277	angiotensin converting enzyme 2	Homo sapiens	24-29
35057501-6	2022	SARS-CoV-2 binding with ACE-2 causes depletion of ACE-2 (angiotensin-converting enzyme 2) from blood vessels, and subsequently, angiotensin-II interacts with angiotensin receptor-1 from vascular membranes that produce NADPH (nicotinamide adenine dinucleotide hydrogen phosphate) oxidase, oxidative stress, and constriction of blood vessels.	nicotinamide adenine dinucleotide hydrogen phosphate	225-277	angiotensin converting enzyme 2	Homo sapiens	50-55
35054856-8	2022	Nicotine and caffeine have similar structures to antiviral drugs, capable of binding angiotensin-converting enzyme 2 (ACE 2) epitopes that are recognized by SARS-CoV-2, with the potential to inhibit the formation of the ACE 2/SARS-CoV-2 complex.	Nicotine	0-8	angiotensin converting enzyme 2	Homo sapiens	85-116
35054856-8	2022	Nicotine and caffeine have similar structures to antiviral drugs, capable of binding angiotensin-converting enzyme 2 (ACE 2) epitopes that are recognized by SARS-CoV-2, with the potential to inhibit the formation of the ACE 2/SARS-CoV-2 complex.	Nicotine	0-8	angiotensin converting enzyme 2	Homo sapiens	118-123
35054856-8	2022	Nicotine and caffeine have similar structures to antiviral drugs, capable of binding angiotensin-converting enzyme 2 (ACE 2) epitopes that are recognized by SARS-CoV-2, with the potential to inhibit the formation of the ACE 2/SARS-CoV-2 complex.	Nicotine	0-8	angiotensin converting enzyme 2	Homo sapiens	220-225
35054856-8	2022	Nicotine and caffeine have similar structures to antiviral drugs, capable of binding angiotensin-converting enzyme 2 (ACE 2) epitopes that are recognized by SARS-CoV-2, with the potential to inhibit the formation of the ACE 2/SARS-CoV-2 complex.	Caffeine	13-21	angiotensin converting enzyme 2	Homo sapiens	85-116
35054856-8	2022	Nicotine and caffeine have similar structures to antiviral drugs, capable of binding angiotensin-converting enzyme 2 (ACE 2) epitopes that are recognized by SARS-CoV-2, with the potential to inhibit the formation of the ACE 2/SARS-CoV-2 complex.	Caffeine	13-21	angiotensin converting enzyme 2	Homo sapiens	118-123
35054856-8	2022	Nicotine and caffeine have similar structures to antiviral drugs, capable of binding angiotensin-converting enzyme 2 (ACE 2) epitopes that are recognized by SARS-CoV-2, with the potential to inhibit the formation of the ACE 2/SARS-CoV-2 complex.	Caffeine	13-21	angiotensin converting enzyme 2	Homo sapiens	220-225
35053224-0	2022	Calcium Signaling Pathway Is Involved in the Shedding of ACE2 Catalytic Ectodomain: New Insights for Clinical and Therapeutic Applications of ACE2 for COVID-19.	Calcium	0-7	angiotensin converting enzyme 2	Homo sapiens	57-61
35053224-0	2022	Calcium Signaling Pathway Is Involved in the Shedding of ACE2 Catalytic Ectodomain: New Insights for Clinical and Therapeutic Applications of ACE2 for COVID-19.	Calcium	0-7	angiotensin converting enzyme 2	Homo sapiens	142-146
35053224-2	2022	The catalytic ectodomain of ACE2 undergoes shedding by a disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), in which calmodulin mediates the calcium signaling pathway that is involved in ACE2 release, resulting in a soluble catalytic ectodomain of ACE2 that can be measured as soluble ACE2 plasma activity.	Calcium	163-170	angiotensin converting enzyme 2	Homo sapiens	28-32
35053224-2	2022	The catalytic ectodomain of ACE2 undergoes shedding by a disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), in which calmodulin mediates the calcium signaling pathway that is involved in ACE2 release, resulting in a soluble catalytic ectodomain of ACE2 that can be measured as soluble ACE2 plasma activity.	Calcium	163-170	angiotensin converting enzyme 2	Homo sapiens	209-213
35053224-8	2022	Furthermore, given that vitamin D enhanced the shedding of ACE2, some studies reported that vitamin D treatment is associated with prognosis improvement in COVID-19.	Vitamin D	24-33	angiotensin converting enzyme 2	Homo sapiens	59-63
35053224-8	2022	Furthermore, given that vitamin D enhanced the shedding of ACE2, some studies reported that vitamin D treatment is associated with prognosis improvement in COVID-19.	Vitamin D	92-101	angiotensin converting enzyme 2	Homo sapiens	59-63
34983356-9	2022	Metformin and statins through immunomodulatory activities, Orlistat by reducing viral replication, and thiazolidinediones by upregulating ACE2 expression have potential beneficial effects against COVID-19.	Thiazolidinediones	103-121	angiotensin converting enzyme 2	Homo sapiens	138-142
34983356-10	2022	However, the combination of dipeptidyl peptidase-4 (DDP4) inhibitors and spironolactone/eplerenone seems to be more effective by reducing soluble ACE2 level, antagonizing TMPRSS2, maintaining ACE2 on cell membrane and reducing risk of viral entry into the cells.	Spironolactone	73-87	angiotensin converting enzyme 2	Homo sapiens	146-150
34983356-10	2022	However, the combination of dipeptidyl peptidase-4 (DDP4) inhibitors and spironolactone/eplerenone seems to be more effective by reducing soluble ACE2 level, antagonizing TMPRSS2, maintaining ACE2 on cell membrane and reducing risk of viral entry into the cells.	Spironolactone	73-87	angiotensin converting enzyme 2	Homo sapiens	192-196
34983356-10	2022	However, the combination of dipeptidyl peptidase-4 (DDP4) inhibitors and spironolactone/eplerenone seems to be more effective by reducing soluble ACE2 level, antagonizing TMPRSS2, maintaining ACE2 on cell membrane and reducing risk of viral entry into the cells.	Eplerenone	88-98	angiotensin converting enzyme 2	Homo sapiens	146-150
34983356-10	2022	However, the combination of dipeptidyl peptidase-4 (DDP4) inhibitors and spironolactone/eplerenone seems to be more effective by reducing soluble ACE2 level, antagonizing TMPRSS2, maintaining ACE2 on cell membrane and reducing risk of viral entry into the cells.	Eplerenone	88-98	angiotensin converting enzyme 2	Homo sapiens	192-196
35432786-5	2022	They also underwent stable docking to the Zn2+ domain of the ACE2 catalytic site as well as the critical interfacial region between ACE2 and the SARS-CoV-2 receptor binding domain.	Zinc	42-46	angiotensin converting enzyme 2	Homo sapiens	61-65
35251533-6	2022	We identified residue 493 in delta (glutamine) and omicron (arginine) with altered binding properties towards ACE2.	delta	29-34	angiotensin converting enzyme 2	Homo sapiens	110-114
35251533-6	2022	We identified residue 493 in delta (glutamine) and omicron (arginine) with altered binding properties towards ACE2.	Glutamine	36-45	angiotensin converting enzyme 2	Homo sapiens	110-114
35251533-6	2022	We identified residue 493 in delta (glutamine) and omicron (arginine) with altered binding properties towards ACE2.	Arginine	60-68	angiotensin converting enzyme 2	Homo sapiens	110-114
35011708-8	2022	Moreover, S-EV uptake was significantly decreased by anti-ACE2 antibody pre-treatment.	s-ev	10-14	angiotensin converting enzyme 2	Homo sapiens	58-62
35590466-4	2022	SARS-CoV-2 binds erythrocyte band3 protein, which has a similar characteristic of ACE2, leading to alteration of erythrocyte physiology like oxygen transport with development of hypoxia.	Oxygen	141-147	angiotensin converting enzyme 2	Homo sapiens	82-86
35002530-0	2022	Propionate alleviates myocardial ischemia-reperfusion injury aggravated by Angiotensin II dependent on caveolin-1/ACE2 axis through GPR41.	Propionates	0-10	angiotensin converting enzyme 2	Homo sapiens	114-118
35002530-8	2022	Taken together, propionate alleviates myocardial I/R injury aggravated by Ang II dependent on CAV-1/ACE2 axis through GPR41, which provides a new direction that diet to regulate the intestinal flora for treatment of myocardial I/R injury.	Propionates	16-26	angiotensin converting enzyme 2	Homo sapiens	100-104
35432786-4	2022	In silico docking and molecular dynamics studies revealed bisartans exhibited higher binding affinities for the ACE2/spike protein complex (PDB 6LZG) compared to all other known sartans.	bisartans	58-67	angiotensin converting enzyme 2	Homo sapiens	112-116
35136832-5	2022	The cell-surface Glucose Regulated Protein 78 (GRP78) attached to the mutated ACE2-SARS-CoV-2 Spike RBD complex is modeled.	Glucose	17-24	angiotensin converting enzyme 2	Homo sapiens	78-82
35228443-8	2022	Furthermore, we utilized the already approved drugs that inhibit TRPC3-Nox2 protein complex formation, and identified that clomipramine, a tricyclic antidepressant, has the best potency to suppress ACE2 internalization induced by S protein exposure.	Clomipramine	123-135	angiotensin converting enzyme 2	Homo sapiens	198-202
35289719-4	2022	The structure of NIH-CoVnb-112 bound to SARS-CoV-2 RBD reveals a large contact surface area overlapping the angiotensin converting enzyme 2 (ACE2) binding site, which is largely unencumbered by the common RBD mutations.	nih-covnb-112	17-30	angiotensin converting enzyme 2	Homo sapiens	108-139
35289719-4	2022	The structure of NIH-CoVnb-112 bound to SARS-CoV-2 RBD reveals a large contact surface area overlapping the angiotensin converting enzyme 2 (ACE2) binding site, which is largely unencumbered by the common RBD mutations.	nih-covnb-112	17-30	angiotensin converting enzyme 2	Homo sapiens	141-145
35289719-6	2022	These findings support the further development of NIH-CoVnb-112 as a potential adjunct preventative therapeutic for the treatment of SARS-CoV-2 infection.Abbreviations: ACE2 - angiotensin converting enzyme 2BSA - buried surface areaCDR - complementary determining regionRBD - receptor binding domainRBM - receptor-binding motifSARS-CoV-2 - severe acute respiratory syndrome coronavirus 2.	nih-covnb-112	50-63	angiotensin converting enzyme 2	Homo sapiens	169-173
35189759-0	2022	Sudan Black B treatment uncovers the distribution of angiotensin-converting enzyme2 in nociceptors.	Sudan Black B	0-13	angiotensin converting enzyme 2	Homo sapiens	53-83
35176079-5	2022	Angiotensin-1 converting enzyme 2 (ACE2), is the key regulator of blood pressure in the Renin-Angiotensin-Aldosterone System that hydrolyzes angiotensin II (vasoconstrictor) into angiotensin 1-7 (vasodilator).	Aldosterone	106-117	angiotensin converting enzyme 2	Homo sapiens	0-33
35136839-6	2022	Results: Blind-docking of mutated-CUTs in ACE2 completely rejected the nCOV2 binding to ACE2.	ncov2	71-76	angiotensin converting enzyme 2	Homo sapiens	88-92
35370738-7	2022	Modulation by metformin of the cell-surface ACE2 protein (a key binding target for SARS-CoV 2 spike protein) via the AMP kinase pathway may be involved.	Metformin	14-23	angiotensin converting enzyme 2	Homo sapiens	44-48
35176079-5	2022	Angiotensin-1 converting enzyme 2 (ACE2), is the key regulator of blood pressure in the Renin-Angiotensin-Aldosterone System that hydrolyzes angiotensin II (vasoconstrictor) into angiotensin 1-7 (vasodilator).	Aldosterone	106-117	angiotensin converting enzyme 2	Homo sapiens	35-39