PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34370586-2 2021 titled, "Key Metabolic Enzymes in Remdesivir Activation in Lung Cells," validates the canonical McGuigan enzymes (CES1, CTSA, HINT1) involved in remdesivir"s (RDV"s) bioactivation using bioinformatic and biochemical approaches (1)..... remdesivir 34-44 histidine triad nucleotide binding protein 1 Homo sapiens 126-131 34370586-2 2021 titled, "Key Metabolic Enzymes in Remdesivir Activation in Lung Cells," validates the canonical McGuigan enzymes (CES1, CTSA, HINT1) involved in remdesivir"s (RDV"s) bioactivation using bioinformatic and biochemical approaches (1)..... remdesivir 145-155 histidine triad nucleotide binding protein 1 Homo sapiens 126-131 34125594-4 2021 Our data collectively demonstrated that carboxylesterase 1 (CES1) and cathepsin A (CatA) are enzymes involved in hydrolyzing RDV to its alanine intermediate Met X, which is further hydrolyzed to the monophosphate form by histidine triad nucleotide-binding protein 1 (HINT1). remdesivir 125-128 histidine triad nucleotide binding protein 1 Homo sapiens 221-265 34125594-4 2021 Our data collectively demonstrated that carboxylesterase 1 (CES1) and cathepsin A (CatA) are enzymes involved in hydrolyzing RDV to its alanine intermediate Met X, which is further hydrolyzed to the monophosphate form by histidine triad nucleotide-binding protein 1 (HINT1). remdesivir 125-128 histidine triad nucleotide binding protein 1 Homo sapiens 267-272