PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2905688-4 1988 Molecular cloning and sequencing of both the alleles of p53 gene revealed a base-pair change in codon 72 causing arginine----proline substitution in the allele with the additional BglII site. Proline 125-132 tumor protein p53 Homo sapiens 56-59 33823140-5 2021 p53-regulated speckle association did not depend on p53 transactivation functions but required an intact proline-rich domain and direct DNA binding, providing mechanisms within p53 for regulating gene-speckle association. Proline 105-112 tumor protein p53 Homo sapiens 0-3 3025664-10 1986 This sequence difference resulted in an arginine being coded for in clone p53-H-1 and a proline being coded for at the equivalent position in clone p53-H-19. Proline 88-95 tumor protein p53 Homo sapiens 148-151 32592343-1 2020 BACKGROUND: A transversion missense polymorphism of the TP53 tumor suppressor gene at the codon 72 codes proline instead of arginine causes an altered p53 protein expression and has been found to be associated with an elevated risk of various cancer; especially breast and lung cancer. Proline 105-112 tumor protein p53 Homo sapiens 56-60 32727419-8 2020 CONCLUSIONS: This pilot study suggests that both the Arg/Arg and Arg/Pro genotypes of p53 codon 72 polymorphism may have value as independent prognostic or predictive parameters for bevacizumab treatment response and failure. Proline 69-72 tumor protein p53 Homo sapiens 86-89 32711437-12 2020 Significant increased risk of lung cancer was found with Arg/Pro genotypes of TP53, Lys/Gln and Gln/Gln variants of XPD in individuals with family history of cancer (OR=3.44; 95% CI=1.36-8.72; p=0.011; OR=3.17; 95% CI=1.20-8.39; p=0.024; OR=16.35; 95% CI=0.92-289.5; p=0.007, respectively). Proline 61-64 tumor protein p53 Homo sapiens 78-82 32592343-1 2020 BACKGROUND: A transversion missense polymorphism of the TP53 tumor suppressor gene at the codon 72 codes proline instead of arginine causes an altered p53 protein expression and has been found to be associated with an elevated risk of various cancer; especially breast and lung cancer. Proline 105-112 tumor protein p53 Homo sapiens 151-154 32424519-5 2020 The results indicate that the TP53 Arg/Pro heterozygosity (adjusted OR 2.32, 95% CI 1.28-4.34, p = 0.01), Pro/Pro mutant homozygosity (adjusted OR 4.15, 95% CI 1.75-9.86, p = 0.001), along with the combined genotype (Arg/Pro + Pro/Pro) (adjusted OR 2.83, 95% CI 1.61-4.97, p < 0.001) significantly increases the risk of cervical cancer. Proline 39-42 tumor protein p53 Homo sapiens 30-34 32424519-6 2020 Moreover, the cervical cancer patients with a first-degree relative cancer patient possesses 4.45 folds more risk (p = 0.019) of carrying a proline allele in codon 72 of the TP53 gene compared to those patients who do not have any first-degree relative with cancer. Proline 140-147 tumor protein p53 Homo sapiens 174-178 31578743-9 2019 CONCLUSIONS: The TP53 codon 72 Pro/Pro polymorphism may isolate a relatively high-risk patient group in T1N1M0/T2N0M0/T3N0M0 gastric cancer. Proline 31-34 tumor protein p53 Homo sapiens 17-21 32213586-4 2020 Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth. Proline 29-36 tumor protein p53 Homo sapiens 146-149 32213586-4 2020 Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth. Proline 64-71 tumor protein p53 Homo sapiens 146-149 32213586-4 2020 Intriguingly, expressions of proline biosynthesis PYCR gene and proline degradation PRODH gene are up-regulated directly by c-Myc oncoprotein and p53 tumor suppressor, respectively, suggesting that the proline-P5C metabolic axis is a key checkpoint for tumor cell growth. Proline 64-71 tumor protein p53 Homo sapiens 146-149 31578743-9 2019 CONCLUSIONS: The TP53 codon 72 Pro/Pro polymorphism may isolate a relatively high-risk patient group in T1N1M0/T2N0M0/T3N0M0 gastric cancer. Proline 35-38 tumor protein p53 Homo sapiens 17-21 31369573-5 2019 RESULTS: The allele frequency of TP53 codon 72 in our cohort was 37, 42, and 21% for Arg/Arg, Arg/Pro, and Pro/Pro, respectively. Proline 98-101 tumor protein p53 Homo sapiens 33-37 31366730-3 2019 Here, we identified a relatively rare mutation leading to a proline to leucine substitution (P152L) in TP53 at the very end of its DNA-binding domain (DBD) in a sample from an Indian oral cancer patient. Proline 60-67 tumor protein p53 Homo sapiens 103-107 31369573-5 2019 RESULTS: The allele frequency of TP53 codon 72 in our cohort was 37, 42, and 21% for Arg/Arg, Arg/Pro, and Pro/Pro, respectively. Proline 107-110 tumor protein p53 Homo sapiens 33-37 31369573-5 2019 RESULTS: The allele frequency of TP53 codon 72 in our cohort was 37, 42, and 21% for Arg/Arg, Arg/Pro, and Pro/Pro, respectively. Proline 107-110 tumor protein p53 Homo sapiens 33-37 30988205-3 2019 The p53 N terminus (NT) contains two transactivation domains (TAD1 and TAD2), a proline-rich region (PRR), and multiple phosphorylation sites. Proline 80-87 tumor protein p53 Homo sapiens 4-7 31128065-0 2019 TP53 Gene 72 Arg/Pro (rs1042522) Single Nucleotide Polymorphism Contribute to Increase the Risk of B-Chronic Lymphocytic Leukemia in the Sudanese Population Objective: This study aimed at exploring the association of TP53 72Arg/Pro polymorphism and Risk of ChronicLymphocytic Leukemia and to assess the correlation between TP53 72Arg/Pro polymorphism and clinical parameter,hematological profile and some biological prognostic markers among Sudanese patients with chronic lymphocyticleukemia. Proline 17-20 tumor protein p53 Homo sapiens 0-4 31128065-0 2019 TP53 Gene 72 Arg/Pro (rs1042522) Single Nucleotide Polymorphism Contribute to Increase the Risk of B-Chronic Lymphocytic Leukemia in the Sudanese Population Objective: This study aimed at exploring the association of TP53 72Arg/Pro polymorphism and Risk of ChronicLymphocytic Leukemia and to assess the correlation between TP53 72Arg/Pro polymorphism and clinical parameter,hematological profile and some biological prognostic markers among Sudanese patients with chronic lymphocyticleukemia. Proline 17-20 tumor protein p53 Homo sapiens 217-221 31128065-0 2019 TP53 Gene 72 Arg/Pro (rs1042522) Single Nucleotide Polymorphism Contribute to Increase the Risk of B-Chronic Lymphocytic Leukemia in the Sudanese Population Objective: This study aimed at exploring the association of TP53 72Arg/Pro polymorphism and Risk of ChronicLymphocytic Leukemia and to assess the correlation between TP53 72Arg/Pro polymorphism and clinical parameter,hematological profile and some biological prognostic markers among Sudanese patients with chronic lymphocyticleukemia. Proline 17-20 tumor protein p53 Homo sapiens 217-221 30651598-2 2019 Human epidemiological studies reveal that a p53 single-nucleotide polymorphism (SNP) at codon 72, encoding proline (P72) or arginine (R72), is associated with differential risk of several cancers, including BrCa. Proline 107-114 tumor protein p53 Homo sapiens 44-47 30607176-8 2018 The genotypic distribution at codon 72 of TP53 in control group was 20%, 62.4% and 16.6% for Arg (wildtype), Arg/Pro (heterozygous) and Pro (homozygous variant) respectively. Proline 113-116 tumor protein p53 Homo sapiens 42-46 30288482-4 2018 Objective: This study was designed to examine associations of TP53 72 Arg>Pro (rs1042522), and MDM2 309 T>G (rs937283) polymorphisms with spermatogenetic failure in Iranian population. Proline 77-80 tumor protein p53 Homo sapiens 62-66 30774789-2 2018 Our research was aimed to study p53 protein codon 72 polymorphism, a single base pair change of either arginine (Arg; CGC) or proline (Pro; CCC) that creates 3 distinct genotypes in reticular oral lichen planus (OLP) in comparison to oral SCC which is the most common oral mucosal malignancy as positive control and inflammatory fibrous hyperplasia (IFH) lesion as negative control. Proline 126-133 tumor protein p53 Homo sapiens 32-35 30774789-2 2018 Our research was aimed to study p53 protein codon 72 polymorphism, a single base pair change of either arginine (Arg; CGC) or proline (Pro; CCC) that creates 3 distinct genotypes in reticular oral lichen planus (OLP) in comparison to oral SCC which is the most common oral mucosal malignancy as positive control and inflammatory fibrous hyperplasia (IFH) lesion as negative control. Proline 135-138 tumor protein p53 Homo sapiens 32-35 30288482-6 2018 The two polymorphisms, 72 Arg>Pro in TP53 and 309 T>G in MDM2, were genotyped using PCR-RFLP and ARMS-PCR respectively. Proline 33-36 tumor protein p53 Homo sapiens 40-44 30067985-0 2018 PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359. Proline 54-61 tumor protein p53 Homo sapiens 15-18 30067985-3 2018 Here, we show that PHD3 hydroxylates p53 at proline 359, a residue that is in the p53-DUB binding domain. Proline 44-51 tumor protein p53 Homo sapiens 37-40 30067985-3 2018 Here, we show that PHD3 hydroxylates p53 at proline 359, a residue that is in the p53-DUB binding domain. Proline 44-51 tumor protein p53 Homo sapiens 82-85 30067985-4 2018 Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression. Proline 26-33 tumor protein p53 Homo sapiens 17-20 30067985-4 2018 Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression. Proline 26-33 tumor protein p53 Homo sapiens 133-136 30067985-4 2018 Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression. Proline 26-33 tumor protein p53 Homo sapiens 133-136 30067985-4 2018 Hydroxylation of p53 upon proline 359 regulates its interaction with USP7 and USP10, and its inhibition decreases the association of p53 with USP7/USP10, increases p53 ubiquitination, and rapidly reduces p53 protein levels independently of mRNA expression. Proline 26-33 tumor protein p53 Homo sapiens 133-136 29261364-1 2018 BACKGROUND: The TP53 codon 72 Proline-Arginine polymorphism (TP53 P72R) is the most widely studied candidate among those evaluated for a putative association between impaired apoptosis and glaucoma. Proline 30-37 tumor protein p53 Homo sapiens 16-20 29936711-4 2018 Researchers observed thata protective genetic variant TP53 codon 72 proline allele was more commonly found in this population and appear tobe over-transmitted compared to others known for their high rate of cervical cancer. Proline 68-75 tumor protein p53 Homo sapiens 54-58 29261364-1 2018 BACKGROUND: The TP53 codon 72 Proline-Arginine polymorphism (TP53 P72R) is the most widely studied candidate among those evaluated for a putative association between impaired apoptosis and glaucoma. Proline 30-37 tumor protein p53 Homo sapiens 61-65 28214592-4 2017 We found that the polymorphism rs1042522:C > G in codon 72 of exon 4 of the TP53 gene, whose C variant produces a proline and is more common in most ethnicities, has a G variant producing an arginine in 79.8% of NFPAs (n = 42; p < 1.411 x 10-18 vs. 1000 Genomes database), causing patients to present a decade earlier with symptomatic NFPAs. Proline 117-124 tumor protein p53 Homo sapiens 79-83 29557783-3 2018 In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences p53 activity; the P72 allele has a weaker p53 activity and function in tumor suppression. Proline 78-85 tumor protein p53 Homo sapiens 115-118 29557783-3 2018 In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences p53 activity; the P72 allele has a weaker p53 activity and function in tumor suppression. Proline 78-85 tumor protein p53 Homo sapiens 157-160 29126407-7 2017 RESULTS: Patients with Arg/Arg and Arg/Pro at codon 72 of TP53 had a higher complete response rate (61% vs. 44%, P = 0.007) than those with Pro/Pro. Proline 39-42 tumor protein p53 Homo sapiens 58-62 28789369-5 2017 Notably, the Pro72 allele was significantly enriched in patients with ESCC compared with its abundance in the healthy control group, and the genotype of Pro/Arg on p53 codon 72 was confirmed to exhibit a significant correlation with ESCC in Mongolian patients. Proline 13-16 tumor protein p53 Homo sapiens 164-167 28789369-7 2017 Mongolian patients who carry the partocular genotype of Arg/Pro or Pro/Pro on p53 codon 72 may be more likely to develop ESCC. Proline 60-63 tumor protein p53 Homo sapiens 78-81 28789369-7 2017 Mongolian patients who carry the partocular genotype of Arg/Pro or Pro/Pro on p53 codon 72 may be more likely to develop ESCC. Proline 67-70 tumor protein p53 Homo sapiens 78-81 28789369-7 2017 Mongolian patients who carry the partocular genotype of Arg/Pro or Pro/Pro on p53 codon 72 may be more likely to develop ESCC. Proline 67-70 tumor protein p53 Homo sapiens 78-81 29479097-9 2018 CONCLUSIONS: In Pakistani women the association of TP53 gene codon 72 arginine/proline polymorphism was present.. Proline 79-86 tumor protein p53 Homo sapiens 51-55 29233996-4 2017 PEPD binds to the proline-rich domain in p53, which inhibits phosphorylation of nuclear p53 and MDM2-mediated mitochondrial translocation of nuclear and cytoplasmic p53. Proline 18-25 tumor protein p53 Homo sapiens 41-44 29233996-4 2017 PEPD binds to the proline-rich domain in p53, which inhibits phosphorylation of nuclear p53 and MDM2-mediated mitochondrial translocation of nuclear and cytoplasmic p53. Proline 18-25 tumor protein p53 Homo sapiens 88-91 29233996-4 2017 PEPD binds to the proline-rich domain in p53, which inhibits phosphorylation of nuclear p53 and MDM2-mediated mitochondrial translocation of nuclear and cytoplasmic p53. Proline 18-25 tumor protein p53 Homo sapiens 88-91 29222481-6 2017 Furthermore, HIF-P4H-1 inactivation increases p53 activity and stability and hydroxylation of proline 142 in p53 has an important role in this regulation. Proline 94-101 tumor protein p53 Homo sapiens 109-112 29308362-6 2017 Molecular analysis of p53 codon 72 gene polymorphism was performed by polymerase chain reaction - restriction fragment length polymorphism for Arg/Arg, Arg/Pro, and Pro/Pro. Proline 156-159 tumor protein p53 Homo sapiens 22-25 29308362-6 2017 Molecular analysis of p53 codon 72 gene polymorphism was performed by polymerase chain reaction - restriction fragment length polymorphism for Arg/Arg, Arg/Pro, and Pro/Pro. Proline 165-168 tumor protein p53 Homo sapiens 22-25 29308362-6 2017 Molecular analysis of p53 codon 72 gene polymorphism was performed by polymerase chain reaction - restriction fragment length polymorphism for Arg/Arg, Arg/Pro, and Pro/Pro. Proline 165-168 tumor protein p53 Homo sapiens 22-25 28475405-3 2017 A common coding region variant at amino acid 72 of p53 encodes either proline (P72) or arginine (R72). Proline 70-77 tumor protein p53 Homo sapiens 51-54 29333597-2 2017 TP53 codon 72 polymorphism (P72R) results in proline (P) or arginine (R) at 72 amino acid position, which causes synthesis of proteins with distinct functions. Proline 45-52 tumor protein p53 Homo sapiens 0-4 28357076-5 2017 The distribution frequency of p53 sites of arginine (Arg)/Arg, Arg/proline (Pro), Pro/Pro were 18.4, 48.8 and 32.8% in the control group, as compared with 18.7, 49.9 and 31.4% in the case group, which indicated that there was no difference between two groups (chi2=0.14; P=0.93). Proline 67-74 tumor protein p53 Homo sapiens 30-33 27768124-5 2017 The human Tp53 gene harbors a common single-nucleotide polymorphism (SNP) at codon 72, which yields an arginine-to-proline amino-acidic substitution (Arg72Pro) that modulates the apoptotic activity of the p53 protein. Proline 115-122 tumor protein p53 Homo sapiens 10-14 27768124-5 2017 The human Tp53 gene harbors a common single-nucleotide polymorphism (SNP) at codon 72, which yields an arginine-to-proline amino-acidic substitution (Arg72Pro) that modulates the apoptotic activity of the p53 protein. Proline 115-122 tumor protein p53 Homo sapiens 11-14 27376811-2 2016 The change from an arginine (Arg) to a proline (Pro) at codon 72 can influence the biological activity of p53, which predisposes to an increased risk of recurrent spontaneous abortion (RSA). Proline 39-46 tumor protein p53 Homo sapiens 106-109 28033105-6 2016 Multivariate analysis showed a significant association with NSCLC for the combination between the TP53 codon72 Arg/Pro and the Pro/Pro genotypes (OR 2.21, 95 % CI 1.390-3.51; p=0.001). Proline 115-118 tumor protein p53 Homo sapiens 98-102 27304453-10 2016 The results revealed that (1) homozygosity of the Pro72 variant of p53 was present in 26 laryngeal carcinoma patients (65%), (2) heterozygosity for the Pro/Arg genotype was present in 13 patients (32.5%), and (3) the Arg72 variant of the p53 allele was present in 1 patient (2.5%) before treatment. Proline 50-53 tumor protein p53 Homo sapiens 67-70 27376811-2 2016 The change from an arginine (Arg) to a proline (Pro) at codon 72 can influence the biological activity of p53, which predisposes to an increased risk of recurrent spontaneous abortion (RSA). Proline 48-51 tumor protein p53 Homo sapiens 106-109 27376811-7 2016 There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not. Proline 101-104 tumor protein p53 Homo sapiens 44-47 27376811-7 2016 There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not. Proline 105-108 tumor protein p53 Homo sapiens 44-47 27376811-7 2016 There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not. Proline 105-108 tumor protein p53 Homo sapiens 44-47 27376811-7 2016 There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not. Proline 105-108 tumor protein p53 Homo sapiens 44-47 27376811-7 2016 There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not. Proline 105-108 tumor protein p53 Homo sapiens 44-47 26420962-4 2015 A single nucleotide polymorphism (SNP) in the TP53 gene resulting in the presence of either arginine (Arg) or proline (Pro) or both at codon 72 was shown to alter TP53 tumor-suppressor properties. Proline 110-117 tumor protein p53 Homo sapiens 46-50 26909997-6 2016 TP53*72 showed genotypic distribution: in the control group, there was 16.10% homozygous Pro, and 42.44% heterozygous and 41.46% homozygous Arg; in the BC group, there was 15.43% homozygous Pro, and 42.55% heterozygous and 42.02% homozygous Arg. Proline 89-92 tumor protein p53 Homo sapiens 0-4 26909997-6 2016 TP53*72 showed genotypic distribution: in the control group, there was 16.10% homozygous Pro, and 42.44% heterozygous and 41.46% homozygous Arg; in the BC group, there was 15.43% homozygous Pro, and 42.55% heterozygous and 42.02% homozygous Arg. Proline 190-193 tumor protein p53 Homo sapiens 0-4 26718886-9 2016 The patients with a proline (Pro) polymorphism in SNP72 of TP53 showed significantly higher PrP-positive rates than those with arginine (Arg). Proline 20-27 tumor protein p53 Homo sapiens 59-63 26718886-9 2016 The patients with a proline (Pro) polymorphism in SNP72 of TP53 showed significantly higher PrP-positive rates than those with arginine (Arg). Proline 29-32 tumor protein p53 Homo sapiens 59-63 27159678-3 2016 Single-nucleotide polymorphism of p53 at codon72 leading to substitution of proline (Pro) in place of arginine (Arg) has been identified as a risk factor for development of many cancers, including nasopharyngeal carcinoma (NPC). Proline 76-83 tumor protein p53 Homo sapiens 34-37 27159678-3 2016 Single-nucleotide polymorphism of p53 at codon72 leading to substitution of proline (Pro) in place of arginine (Arg) has been identified as a risk factor for development of many cancers, including nasopharyngeal carcinoma (NPC). Proline 85-88 tumor protein p53 Homo sapiens 34-37 26785263-1 2016 BACKGROUND: In human papillomavirus (HPV)-induced carcinogenesis, the arginine (Arg) allele of the TP53 codon 72 polymorphism binds more efficiently to the HPV E6 oncoprotein than the proline (Pro) allele. Proline 184-191 tumor protein p53 Homo sapiens 99-103 26785263-1 2016 BACKGROUND: In human papillomavirus (HPV)-induced carcinogenesis, the arginine (Arg) allele of the TP53 codon 72 polymorphism binds more efficiently to the HPV E6 oncoprotein than the proline (Pro) allele. Proline 193-196 tumor protein p53 Homo sapiens 99-103 26782376-10 2015 Analysis of p53 gene polymorphisms showed a higher frequency for the genotype Arg/Pro (66%) and a lower frequency for the Arg/Arg (23%) and Pro/Pro (11%) genotypes. Proline 82-85 tumor protein p53 Homo sapiens 12-15 26782376-10 2015 Analysis of p53 gene polymorphisms showed a higher frequency for the genotype Arg/Pro (66%) and a lower frequency for the Arg/Arg (23%) and Pro/Pro (11%) genotypes. Proline 140-143 tumor protein p53 Homo sapiens 12-15 26782376-10 2015 Analysis of p53 gene polymorphisms showed a higher frequency for the genotype Arg/Pro (66%) and a lower frequency for the Arg/Arg (23%) and Pro/Pro (11%) genotypes. Proline 140-143 tumor protein p53 Homo sapiens 12-15 26188904-0 2015 TLR2 22 (-196-174) significantly increases the risk of breast cancer in females carrying proline allele at codon 72 of TP53 gene: a case-control study from four ethnic groups of North Eastern region of India. Proline 89-96 tumor protein p53 Homo sapiens 119-123 26420962-4 2015 A single nucleotide polymorphism (SNP) in the TP53 gene resulting in the presence of either arginine (Arg) or proline (Pro) or both at codon 72 was shown to alter TP53 tumor-suppressor properties. Proline 110-117 tumor protein p53 Homo sapiens 163-167 26420962-4 2015 A single nucleotide polymorphism (SNP) in the TP53 gene resulting in the presence of either arginine (Arg) or proline (Pro) or both at codon 72 was shown to alter TP53 tumor-suppressor properties. Proline 119-122 tumor protein p53 Homo sapiens 46-50 26420962-4 2015 A single nucleotide polymorphism (SNP) in the TP53 gene resulting in the presence of either arginine (Arg) or proline (Pro) or both at codon 72 was shown to alter TP53 tumor-suppressor properties. Proline 119-122 tumor protein p53 Homo sapiens 163-167 26405550-6 2015 Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P<0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC. Proline 262-269 tumor protein p53 Homo sapiens 40-43 25232917-8 2015 Patients with homozygous Arg/arg at codon 72 of P53 had a better median OS months than Arg/Pro and Pro/Pro (13.4 vs. 8.4 vs. 1.5 months, respectively; P = 0.045). Proline 91-94 tumor protein p53 Homo sapiens 48-51 26405550-6 2015 Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P<0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC. Proline 271-274 tumor protein p53 Homo sapiens 40-43 26405550-6 2015 Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P<0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC. Proline 276-279 tumor protein p53 Homo sapiens 40-43 26405550-6 2015 Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P<0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC. Proline 276-279 tumor protein p53 Homo sapiens 40-43 26236013-0 2015 Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis. Proline 13-20 tumor protein p53 Homo sapiens 48-51 26236013-3 2015 We observed that cis-trans isomerization of proline 47 (Pro47) within p53, an inherently rare molecular event, was required for BAX activation. Proline 44-51 tumor protein p53 Homo sapiens 70-73 25232917-8 2015 Patients with homozygous Arg/arg at codon 72 of P53 had a better median OS months than Arg/Pro and Pro/Pro (13.4 vs. 8.4 vs. 1.5 months, respectively; P = 0.045). Proline 99-102 tumor protein p53 Homo sapiens 48-51 25232917-8 2015 Patients with homozygous Arg/arg at codon 72 of P53 had a better median OS months than Arg/Pro and Pro/Pro (13.4 vs. 8.4 vs. 1.5 months, respectively; P = 0.045). Proline 99-102 tumor protein p53 Homo sapiens 48-51 25226867-7 2015 TP53 sequence analysis of the index patient revealed the germline mutation c.1025G > C in a heterozygous state, resulting in an amino acid exchange from arginine to proline (p.Arg342Pro) in the tetramerization domain of p53. Proline 168-175 tumor protein p53 Homo sapiens 0-4 26123760-10 2015 However, a significant association between p53 Arg72Pro polymorphism and the risk of oral cancer with HPV infection was detected in the Arg/Arg vs. Arg/Pro + Pro/Pro model. Proline 52-55 tumor protein p53 Homo sapiens 43-46 26123760-10 2015 However, a significant association between p53 Arg72Pro polymorphism and the risk of oral cancer with HPV infection was detected in the Arg/Arg vs. Arg/Pro + Pro/Pro model. Proline 152-155 tumor protein p53 Homo sapiens 43-46 26123760-10 2015 However, a significant association between p53 Arg72Pro polymorphism and the risk of oral cancer with HPV infection was detected in the Arg/Arg vs. Arg/Pro + Pro/Pro model. Proline 152-155 tumor protein p53 Homo sapiens 43-46 25840370-0 2015 The cis conformation of proline leads to weaker binding of a p53 peptide to MDM2 compared to trans. Proline 24-31 tumor protein p53 Homo sapiens 61-64 25840370-3 2015 In this study, computer simulations were used to calculate the absolute binding affinity for a p53 peptide (residues 17-29) to MDM2 for both cis and trans isomers of the p53 proline in position 27. Proline 174-181 tumor protein p53 Homo sapiens 95-98 25840370-3 2015 In this study, computer simulations were used to calculate the absolute binding affinity for a p53 peptide (residues 17-29) to MDM2 for both cis and trans isomers of the p53 proline in position 27. Proline 174-181 tumor protein p53 Homo sapiens 170-173 26064201-1 2015 BACKGROUND: The polymorphism of TP53 codon 72, a transversion of G to C (Arg to Pro), has been demonstrated to be associated with the risk for lung cancer. Proline 80-83 tumor protein p53 Homo sapiens 32-36 25226867-7 2015 TP53 sequence analysis of the index patient revealed the germline mutation c.1025G > C in a heterozygous state, resulting in an amino acid exchange from arginine to proline (p.Arg342Pro) in the tetramerization domain of p53. Proline 168-175 tumor protein p53 Homo sapiens 223-226 26745067-4 2015 In HeLa S3 cells treated with siRNA for HPV E6, adenovirus-mediated transduction was enhanced by an upstream ERE linked to a p53 gene carrying a proline variant at codon 72, but not for a p53 gene with arginine variant at codon 72. Proline 145-152 tumor protein p53 Homo sapiens 125-128 25261582-2 2015 The tumour-suppressor p53 protein presents a proline-rich region that is crucial for regulating apoptosis by connecting the p53 with a complex protein network. Proline 45-52 tumor protein p53 Homo sapiens 22-25 25261582-2 2015 The tumour-suppressor p53 protein presents a proline-rich region that is crucial for regulating apoptosis by connecting the p53 with a complex protein network. Proline 45-52 tumor protein p53 Homo sapiens 124-127 25261582-5 2015 In this article, we analyse the binding of the p53 proline-rich region with a pool of selected polyproline binding domains (i.e. SH3 and WW), and we present the first demonstration that the purified SH3 domains of the CD2AP/Cin85 protein family are able to directly bind the p53 protein, and to discriminate between the two polymorphic variants P72R. Proline 51-58 tumor protein p53 Homo sapiens 47-50 25256710-2 2015 Several genetic polymorphisms exist in TP53, including a proline to arginine variant at amino acid 72 (P72 and R72, respectively); this polymorphism alters p53 function. Proline 57-64 tumor protein p53 Homo sapiens 39-43 25256710-2 2015 Several genetic polymorphisms exist in TP53, including a proline to arginine variant at amino acid 72 (P72 and R72, respectively); this polymorphism alters p53 function. Proline 57-64 tumor protein p53 Homo sapiens 156-159 26745067-5 2015 Expression levels of p53 mRNA and Coxsackie/adenovirus receptor (CAR) mRNA after adenovirus-mediated transfer of an ERE-linked p53 gene (proline variant at codon 72) were higher compared with those after non-ERE-linked p53 gene transfer in siRNA-treated HeLa S3 cells. Proline 137-144 tumor protein p53 Homo sapiens 21-24 26745067-5 2015 Expression levels of p53 mRNA and Coxsackie/adenovirus receptor (CAR) mRNA after adenovirus-mediated transfer of an ERE-linked p53 gene (proline variant at codon 72) were higher compared with those after non-ERE-linked p53 gene transfer in siRNA-treated HeLa S3 cells. Proline 137-144 tumor protein p53 Homo sapiens 127-130 26745067-5 2015 Expression levels of p53 mRNA and Coxsackie/adenovirus receptor (CAR) mRNA after adenovirus-mediated transfer of an ERE-linked p53 gene (proline variant at codon 72) were higher compared with those after non-ERE-linked p53 gene transfer in siRNA-treated HeLa S3 cells. Proline 137-144 tumor protein p53 Homo sapiens 127-130 26745067-6 2015 Western blot analysis showed lower beta-tubulin levels and comparatively higher p53/beta-tubulin or CAR /beta-tubulin ratios in siRNA-treated HeLa S3 cells after adenovirus-mediated ERE-linked p53 gene (proline variant at codon 72) transfer compared with those in non-siRNA-treated cells. Proline 203-210 tumor protein p53 Homo sapiens 193-196 26745067-7 2015 Apoptosis, as measured by annexin V binding, was higher after adenovirus-mediated ERE-linked p53 gene (proline variant at codon 72) transfer compared with that after non-ERE-linked p53 gene transfer in siRNA-treated cells. Proline 103-110 tumor protein p53 Homo sapiens 93-96 25502079-3 2015 A common polymorphism of the p53 codon 72 in exon 4 with two alleles encoding arginine or proline is known at this locus. Proline 90-97 tumor protein p53 Homo sapiens 29-32 25605490-3 2015 Recently, the association between the p53 gene encoding for proline at codon 72 and primary open-angle glaucoma (POAG) has been studied in some ethnic groups. Proline 60-67 tumor protein p53 Homo sapiens 38-41 25712892-1 2014 AIM: Arg72Pro is a polymorphism commonly occurring in the proline-rich domain of Tp53. Proline 58-65 tumor protein p53 Homo sapiens 81-85 24115240-1 2014 BACKGROUND: The TP53 single nucleotide polymorphism (SNP) rs1042522 encodes arginine (Arg) or proline (Pro). Proline 94-101 tumor protein p53 Homo sapiens 16-20 24115240-1 2014 BACKGROUND: The TP53 single nucleotide polymorphism (SNP) rs1042522 encodes arginine (Arg) or proline (Pro). Proline 103-106 tumor protein p53 Homo sapiens 16-20 25244701-4 2014 Using the intrinsically disordered N-terminal region of the p53 protein as an experimental model, a set of proline (PRO) and alanine (ALA) to glycine (GLY) substitution variants were designed to modulate backbone conformational propensities without introducing non-native intramolecular interactions. Proline 107-114 tumor protein p53 Homo sapiens 60-63 25244701-4 2014 Using the intrinsically disordered N-terminal region of the p53 protein as an experimental model, a set of proline (PRO) and alanine (ALA) to glycine (GLY) substitution variants were designed to modulate backbone conformational propensities without introducing non-native intramolecular interactions. Proline 116-119 tumor protein p53 Homo sapiens 60-63 25034526-6 2014 The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in lung cancer were 25.5, 37.7, and 36.8 %, respectively; frequencies in the controls were 53.4, 30.2, and 16.4 %, respectively (p < 0.01). Proline 60-63 tumor protein p53 Homo sapiens 19-22 25108128-9 2014 It was resulted that F0/1-HCV patients have significant differences of P53 at 72 (Pro/Pro and Arg/Arg) genotypes and dominant/recessive genetic models as well as APO-1 -670 A/A genotype and dominant genetic model as compared to F3/4-HCV patients. Proline 82-85 tumor protein p53 Homo sapiens 71-74 25313037-4 2014 XAF1 binds directly to the N-terminal proline-rich domain of p53 and thus interferes with E3 ubiquitin ligase MDM2 binding and ubiquitination of p53. Proline 38-45 tumor protein p53 Homo sapiens 61-64 25034526-6 2014 The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in lung cancer were 25.5, 37.7, and 36.8 %, respectively; frequencies in the controls were 53.4, 30.2, and 16.4 %, respectively (p < 0.01). Proline 69-72 tumor protein p53 Homo sapiens 19-22 25034526-6 2014 The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in lung cancer were 25.5, 37.7, and 36.8 %, respectively; frequencies in the controls were 53.4, 30.2, and 16.4 %, respectively (p < 0.01). Proline 69-72 tumor protein p53 Homo sapiens 19-22 25536560-2 2014 To set of p53-mediated apoptosis gene polymorphisms (TP53 codon 72 Arg/Pro, r21 codon 31 Ser/Arg, MDM2 SNP309) for the occurrence of CLL in patients who were exposed to ionizing radiation (IR) from the Chornobyl accident. Proline 71-74 tumor protein p53 Homo sapiens 10-13 24474455-8 2014 The Arg72Pro-p53 polymorphism showed for the genotypes Arg/Pro and Pro/Pro, and for the Pro allele, a significant association only to the risk for CIN (p<0.03). Proline 9-12 tumor protein p53 Homo sapiens 13-16 24958857-3 2014 Here, we identify apoptosis-stimulating protein of p53 with signature sequences of ankyrin repeat-, SH3 domain-, and proline-rich region-containing protein 2 (ASPP2), a haploinsufficient tumor suppressor, activator of p53, and regulator of cell polarity, as a transcriptional target of signal transducer and activator of transcription 1 (STAT1). Proline 117-124 tumor protein p53 Homo sapiens 51-54 25177931-6 2014 TP53 72 showed the following genotypic distribution: the control group was 29.75% homozygous wild-type (Arg), 47.11% heterozygous (Arg-Pro), and 23.14% homozygous variant (Pro). Proline 135-138 tumor protein p53 Homo sapiens 0-4 23475592-2 2014 This SNP encodes either an arginine or proline at position 72 (R72P) of the p53 protein, which can alter the apoptotic activity of p53 via transcriptional and non-transcriptional mechanisms. Proline 39-46 tumor protein p53 Homo sapiens 76-79 23475592-2 2014 This SNP encodes either an arginine or proline at position 72 (R72P) of the p53 protein, which can alter the apoptotic activity of p53 via transcriptional and non-transcriptional mechanisms. Proline 39-46 tumor protein p53 Homo sapiens 131-134 24474455-8 2014 The Arg72Pro-p53 polymorphism showed for the genotypes Arg/Pro and Pro/Pro, and for the Pro allele, a significant association only to the risk for CIN (p<0.03). Proline 59-62 tumor protein p53 Homo sapiens 13-16 24474455-8 2014 The Arg72Pro-p53 polymorphism showed for the genotypes Arg/Pro and Pro/Pro, and for the Pro allele, a significant association only to the risk for CIN (p<0.03). Proline 59-62 tumor protein p53 Homo sapiens 13-16 24150971-7 2014 The simulation data also predicted that proline content contributed minimally to the native Rh of p53(1-93), which was confirmed by measuring Rh for a substitution variant that had all 22 proline residues changed for glycine. Proline 40-47 tumor protein p53 Homo sapiens 98-101 24710610-2 2014 A common polymorphism of the encoding TP53 gene (codon 72, Pro > Arg, rs1042522) is associated with susceptibility to virus-related and other cancers. Proline 59-62 tumor protein p53 Homo sapiens 38-42 24326769-0 2014 The association between polymorphism of P53 Codon72 Arg/Pro and hepatocellular carcinoma susceptibility: evidence from a meta-analysis of 15 studies with 3,704 cases. Proline 56-59 tumor protein p53 Homo sapiens 40-43 24326769-2 2014 Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis. Proline 48-55 tumor protein p53 Homo sapiens 16-19 24326769-2 2014 Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis. Proline 48-55 tumor protein p53 Homo sapiens 104-107 24326769-2 2014 Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis. Proline 57-60 tumor protein p53 Homo sapiens 16-19 24326769-2 2014 Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis. Proline 57-60 tumor protein p53 Homo sapiens 104-107 24326769-3 2014 It has been suggested that p53 codon72 Arg/Pro polymorphism is associated with susceptibility to hepatocellular carcinoma (HCC). Proline 43-46 tumor protein p53 Homo sapiens 27-30 24326769-10 2014 This meta-analysis suggests that p53 codon72 Arg/Pro polymorphism may be associated with the risk of HCC, especially in subgroup analysis of Asian and Caucasian population, hospital-based population, the female, and the individuals infected with hepatitis virus. Proline 49-52 tumor protein p53 Homo sapiens 33-36 24366026-2 2014 The polymorphism in the p53 72nd codon involves a proline to arginine substitution, leading to changes in gene transcription activity, interaction with other proteins and modulation of apoptosis. Proline 50-57 tumor protein p53 Homo sapiens 24-27 25606382-2 2013 Polymorphism of p53 gene codon 72 Arg/Pro (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis. Proline 38-41 tumor protein p53 Homo sapiens 16-19 25422197-11 2014 The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% and 33.66%) as compared to p53 pro/pro variant (25.74%) in the healthy population. Proline 57-60 tumor protein p53 Homo sapiens 16-19 25606382-2 2013 Polymorphism of p53 gene codon 72 Arg/Pro (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis. Proline 38-41 tumor protein p53 Homo sapiens 84-87 25606382-3 2013 It has been suggested that p53 codon 72 Arg/Pro polymorphism is associated with susceptibility to hepatocellular carcinoma (HCC). Proline 44-47 tumor protein p53 Homo sapiens 27-30 25606382-10 2013 CONCLUSIONS/SIGNIFICANCE: This meta-analysis suggests that p53 codon 72 Arg/Pro polymorphism may be associated with the risk of HCC, especially in subgroup analysis of Asian and Caucasian population, hospital-based population, the female, and the individuals infected with hepatitis virus. Proline 76-79 tumor protein p53 Homo sapiens 59-62 23860773-0 2013 P53 codon 72 Arg/Pro polymorphism and glioma risk: an updated meta-analysis. Proline 17-20 tumor protein p53 Homo sapiens 0-3 23812725-0 2013 P53 codon 72 Arg/Pro polymorphism and lung cancer risk in Asians: an updated meta-analysis. Proline 17-20 tumor protein p53 Homo sapiens 0-3 23837945-8 2013 RESULTS: Patients carrying p53 Arg/Arg or Arg/Pro had a higher risk of esophageal SCC (P<0.001, Odds ratio [OR] 4.98, 95% confidential interval [CI] 3.46-7.17), however, not found in MDM2 rs937283. Proline 46-49 tumor protein p53 Homo sapiens 27-30 24518718-9 2013 CONCLUSIONS: 2-DG could be considered as a potential therapeutic agent that induces cell death (which could be linked to induced oxidative stress) selectively in tumors with p53 mutations (particularly in the proline rich region). Proline 209-216 tumor protein p53 Homo sapiens 174-177 23715779-9 2013 Concerning the histological types of lung cancer, the p53 codon 72 variant exerts risk effect on the lung carcinogenesis in patients with adenocarcinoma (OR Arg/Pro vs. Arg/Arg = 1.10, 95 % CI = 1.00-1.22, P OR = 0.048). Proline 161-164 tumor protein p53 Homo sapiens 54-57 23715779-10 2013 Additionally, subgroup analysis by the smoking status demonstrated that the p53 codon 72 variant seemed to play a protective role in lung carcinogenesis among the non-smokers but not the smokers in the contrast model of Arg/Pro vs. Arg/Arg (OR Arg/Pro vs. Arg/Arg = 0.71, 95 % CI = 0.50-1.00, P OR = 0.049). Proline 224-227 tumor protein p53 Homo sapiens 76-79 23812725-1 2013 The polymorphism of p53 codon 72, a transversion of G to C (Arg to Pro), has been demonstrated to be associated with the risk for lung cancer. Proline 67-70 tumor protein p53 Homo sapiens 20-23 23860773-1 2013 P53 codon 72 Arg/Pro is a C/G variation upstream of the p53 gene on human chromosome 17p13. Proline 17-20 tumor protein p53 Homo sapiens 0-3 23812725-3 2013 Thus, we performed a meta-analysis by pooling all currently available case-control studies to estimate the effect of p53 codon 72 Arg/Pro polymorphism on the development of lung cancer. Proline 134-137 tumor protein p53 Homo sapiens 117-120 23812725-10 2013 The updated meta-analysis suggests that the p53 codon 72 Arg/Pro polymorphism is a risk factor for lung cancer in the Asian population. Proline 61-64 tumor protein p53 Homo sapiens 44-47 23860773-1 2013 P53 codon 72 Arg/Pro is a C/G variation upstream of the p53 gene on human chromosome 17p13. Proline 17-20 tumor protein p53 Homo sapiens 56-59 23860773-10 2013 The relationship of p53 codon 72 Arg/Pro polymorphism with the susceptibility to glioma needs further estimation by more individual studies with high quality across ethnicities. Proline 37-40 tumor protein p53 Homo sapiens 20-23 23860773-9 2013 Our study suggests that the polymorphism of p53 codon 72 Arg/Pro may play a protective role in the development of glioblastoma. Proline 61-64 tumor protein p53 Homo sapiens 44-47 23683469-5 2013 The p53 gene contains a single nucleotide polymorphism at codon 72 of exon 4 which encodes either proline (Pro) or arginine (Arg). Proline 98-105 tumor protein p53 Homo sapiens 4-7 23483183-9 2013 RESULTS: The distribution of Arg/Arg, Arg/Pro, and Pro/Pro genotypes of codon 72 of TP53 gene was: 63.3, 34.7, and 2.0 % in the cervical carcinomas and 58.1, 33.8, and 8.1 % in the control group. Proline 42-45 tumor protein p53 Homo sapiens 84-88 24019961-2 2013 We previously reported that the proline 72 polymorphic variant of p53 (P72) demonstrates increased ability to transactivate a subset of genes, relative to arginine 72 (R72); one of these genes is macrophage colony stimulating factor (CSF1). Proline 32-39 tumor protein p53 Homo sapiens 66-69 23683469-5 2013 The p53 gene contains a single nucleotide polymorphism at codon 72 of exon 4 which encodes either proline (Pro) or arginine (Arg). Proline 107-110 tumor protein p53 Homo sapiens 4-7 23639512-3 2013 The wild-type p53 codon has two common polymorphic variants from a single-base-pair substitution at codon 72, where either C-C-C encodes proline (p53-p72) or C-G-C encodes arginine (p53-R72). Proline 137-144 tumor protein p53 Homo sapiens 14-17 23861960-1 2013 The tumor suppressor p53 was previously shown to markedly up-regulate the expression of the PRODH gene, encoding the proline dehydrogenase (PRODH) enzyme, which catalyzes the first step in proline degradation. Proline 117-124 tumor protein p53 Homo sapiens 21-24 23861960-11 2013 This supports a deeper link between proteins of the p53-family and metabolic pathways, as PRODH modulates the balance of proline and glutamate levels and those of their derivative alpha-keto-glutarate (alpha-KG) under normal and pathological (tumor) conditions. Proline 121-128 tumor protein p53 Homo sapiens 52-55 23564481-0 2013 Association between the p53 codon 72 Arg/Pro polymorphism and hepatocellular carcinoma risk. Proline 41-44 tumor protein p53 Homo sapiens 24-27 23564481-1 2013 Previous studies regarding the association of p53 codon 72 Arg/Pro polymorphism with hepatocellular carcinoma (HCC) risk have provided conflicting and inconclusive findings. Proline 63-66 tumor protein p53 Homo sapiens 46-49 23564481-4 2013 The strength of the association of p53 codon 72 Arg/Pro polymorphism with HCC risk was estimated by the pooled odds ratio (OR) with its corresponding 95 % confidence interval (95 % CI). Proline 52-55 tumor protein p53 Homo sapiens 35-38 23663243-1 2013 BACKGROUND: Codon 72 (Arg/Pro), the most frequently studied single nucleotide polymorphism (SNP) of p53 to date, is associated with the ability of the gene to induce cell apoptosis. Proline 26-29 tumor protein p53 Homo sapiens 100-103 23192640-1 2013 The genetic polymorphism of p53 codon 72 Arg/Pro has been implicated in oral cancer risk, but the results of previous studies remain controversial and ambiguous. Proline 45-48 tumor protein p53 Homo sapiens 28-31 23629966-6 2013 IFN-gamma-induced interaction of HDAC1 and p53 resulted in the deacetylation of p53 and suppression of Bmf expression independent of p53"s proline-rich domain. Proline 139-146 tumor protein p53 Homo sapiens 43-46 23092908-7 2013 RESULTS: The distribution of Arg/Arg, Arg/Pro and Pro/Pro genotypes of codon 72 of the TP53 gene was: 46.8%, 46.8% and 6.4%, respectively in the ovarian carcinomas and 64.3%, 31.4% and 4.3%, respectively in the control group. Proline 50-53 tumor protein p53 Homo sapiens 87-91 23124863-1 2013 The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene in association with human papillomavirus (HPV) 16 E6 variants has been implicated as a risk marker in cervical neoplasia. Proline 32-35 tumor protein p53 Homo sapiens 66-69 23092908-7 2013 RESULTS: The distribution of Arg/Arg, Arg/Pro and Pro/Pro genotypes of codon 72 of the TP53 gene was: 46.8%, 46.8% and 6.4%, respectively in the ovarian carcinomas and 64.3%, 31.4% and 4.3%, respectively in the control group. Proline 42-45 tumor protein p53 Homo sapiens 87-91 23092908-7 2013 RESULTS: The distribution of Arg/Arg, Arg/Pro and Pro/Pro genotypes of codon 72 of the TP53 gene was: 46.8%, 46.8% and 6.4%, respectively in the ovarian carcinomas and 64.3%, 31.4% and 4.3%, respectively in the control group. Proline 50-53 tumor protein p53 Homo sapiens 87-91 23991369-2 2013 In human populations, the p53 gene contains a common single nucleotide polymorphism (SNP) affecting codon 72 that determines whether a proline (P72) or an arginine (R72) is present at this amino acid position of the polypeptide. Proline 135-142 tumor protein p53 Homo sapiens 26-29 23124863-1 2013 The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene in association with human papillomavirus (HPV) 16 E6 variants has been implicated as a risk marker in cervical neoplasia. Proline 39-42 tumor protein p53 Homo sapiens 66-69 23124863-1 2013 The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene in association with human papillomavirus (HPV) 16 E6 variants has been implicated as a risk marker in cervical neoplasia. Proline 39-42 tumor protein p53 Homo sapiens 66-69 22892830-8 2012 In addition, a higher frequency of cytogenetic aberrations was observed in p53 variants having the homozygous proline genotype compared to variants having other genotypes both in patients and healthy individuals. Proline 110-117 tumor protein p53 Homo sapiens 75-78 23053979-0 2012 p53 Codon 72 arginine/proline polymorphism and cancer in Sudan. Proline 22-29 tumor protein p53 Homo sapiens 0-3 23053979-1 2012 The aim of this report is to determine frequencies and associations of p53 codon 72 arg/pro polymorphism with different types of cancer in Sudan. Proline 88-91 tumor protein p53 Homo sapiens 71-74 23053979-8 2012 We concluded that p53 arg/pro polymorphism has different pattern of frequency in different types of cancer among Sudanese patients, indicating perhaps different etiology and biology of these tumours. Proline 26-29 tumor protein p53 Homo sapiens 18-21 22483234-8 2012 We noted that the favorable histology Wilms tumors with a proline residue at position 72 of TP53 tended to have higher immunoexpression of GLUT1, although this immunoexpression did not reach statistical significance in this small set of cases. Proline 58-65 tumor protein p53 Homo sapiens 92-96 22915551-4 2012 p53 is a well-studied transcription factor that has a proline-rich N-terminal ID region containing two activation domains. Proline 54-61 tumor protein p53 Homo sapiens 0-3 22915551-5 2012 High proline content is a property commonly associated with ID, and thus p53 may be a good model system for investigating the biochemical importance of ID. Proline 5-12 tumor protein p53 Homo sapiens 73-76 22356895-9 2012 In contrast, the predictive utility of the 72 Arg/Pro SNP in p53 requires mutational analysis of p53, limiting its routine clinical use. Proline 50-53 tumor protein p53 Homo sapiens 61-64 22796327-3 2012 PRODH expression is inducible by p53, leading to increased proline oxidation, reactive oxygen species formation, and induction of apoptosis. Proline 59-66 tumor protein p53 Homo sapiens 33-36 22903472-5 2012 A non-significant trend towards a good pathological response was shown in patients carrying the Arg/Arg or Arg/Pro TP53 codon 72 gene variant compared to those harboring the Pro/Pro variant (17.6 or 37.9 % vs. 0; p = 0.071). Proline 111-114 tumor protein p53 Homo sapiens 115-119 22052810-2 2012 A single nucleotide polymorphism of TP53 encoding either arginine or proline at codon 72 is suggested to alter in vitro p53 behavior. Proline 69-76 tumor protein p53 Homo sapiens 36-40 22052810-2 2012 A single nucleotide polymorphism of TP53 encoding either arginine or proline at codon 72 is suggested to alter in vitro p53 behavior. Proline 69-76 tumor protein p53 Homo sapiens 120-123 22249977-0 2012 Impact of codon 72 Arg > Pro single nucleotide polymorphism in TP53 gene in the risk of kangri cancer: a case control study in Kashmir. Proline 28-31 tumor protein p53 Homo sapiens 66-70 22356895-9 2012 In contrast, the predictive utility of the 72 Arg/Pro SNP in p53 requires mutational analysis of p53, limiting its routine clinical use. Proline 50-53 tumor protein p53 Homo sapiens 97-100 22737668-5 2012 The discovery that proline degradation is activated by p53 directed our attention to the initiation of apoptosis by proline oxidase/dehydrogenase. Proline 19-26 tumor protein p53 Homo sapiens 55-58 22357201-2 2012 Among TP53 gene polymorphisms, the most studied is the G to C transversion in exon 4 at codon 72, which results in three distinct genotypes, Arg/Arg, Pro/Pro and Arg/Pro, each one encoding different p53 isoforms. Proline 150-153 tumor protein p53 Homo sapiens 6-10 22357201-2 2012 Among TP53 gene polymorphisms, the most studied is the G to C transversion in exon 4 at codon 72, which results in three distinct genotypes, Arg/Arg, Pro/Pro and Arg/Pro, each one encoding different p53 isoforms. Proline 154-157 tumor protein p53 Homo sapiens 6-10 22357201-2 2012 Among TP53 gene polymorphisms, the most studied is the G to C transversion in exon 4 at codon 72, which results in three distinct genotypes, Arg/Arg, Pro/Pro and Arg/Pro, each one encoding different p53 isoforms. Proline 154-157 tumor protein p53 Homo sapiens 6-10 22289634-1 2012 Human TP53 gene is characterised by a polymorphism at codon 72 leading to an Arginine-to-Proline (R/P) substitution. Proline 89-96 tumor protein p53 Homo sapiens 6-10 21607615-2 2012 A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein. Proline 155-162 tumor protein p53 Homo sapiens 115-118 21607615-2 2012 A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein. Proline 155-162 tumor protein p53 Homo sapiens 239-242 21607615-2 2012 A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein. Proline 164-167 tumor protein p53 Homo sapiens 115-118 21607615-2 2012 A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein. Proline 164-167 tumor protein p53 Homo sapiens 239-242 21607615-2 2012 A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein. Proline 216-223 tumor protein p53 Homo sapiens 115-118 21607615-2 2012 A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein. Proline 216-223 tumor protein p53 Homo sapiens 239-242 22901126-2 2012 Ser/Cys polymorphism in hOGG1 and Arg/Pro polymorphism in p53 among 124 patients with lung cancer and 128 normal people were detected using PCR-RFLP. Proline 38-41 tumor protein p53 Homo sapiens 58-61 22502699-2 2012 A common single nucleotide polymorphism located within the proline rich region of TP53 gene at codon 72 in exon 4 encodes either proline or arginine. Proline 59-66 tumor protein p53 Homo sapiens 82-86 22502699-2 2012 A common single nucleotide polymorphism located within the proline rich region of TP53 gene at codon 72 in exon 4 encodes either proline or arginine. Proline 129-136 tumor protein p53 Homo sapiens 82-86 22502699-3 2012 TP53 Arg 72 is more active than TP53 Pro 72 in inducing apoptosis. Proline 37-40 tumor protein p53 Homo sapiens 0-4 22631671-0 2012 Pro variant of TP53 Arg72Pro contributes to gastric cancer risk in Asians: evidence from a meta-analysis. Proline 0-3 tumor protein p53 Homo sapiens 15-19 23049825-3 2012 In this study we evaluate the association between a p53 variant functionally known to influence apoptosis (codon 72 Pro/Arg) and the subset of primary open angle glaucoma (POAG) patients with early loss of central visual field. Proline 116-119 tumor protein p53 Homo sapiens 52-55 22210716-9 2012 Our study indicated that a high prevalence of the genotype Arg/Pro at the p53 codon 72 may contribute to susceptibility to OSCC, especially in combination with the use of carcinogenic tobacco-specific nitrosamine (TSNA)-rich toombak. Proline 63-66 tumor protein p53 Homo sapiens 74-77 22613405-1 2012 OBJECTIVE: The association between codon 72 polymorphism of the tumour protein p53 (TP53) gene - which results in a missense mutation of arginine (R) to proline (P) - and susceptibility to hepatocellular carcinoma (HCC) is controversial. Proline 153-160 tumor protein p53 Homo sapiens 79-82 22613405-1 2012 OBJECTIVE: The association between codon 72 polymorphism of the tumour protein p53 (TP53) gene - which results in a missense mutation of arginine (R) to proline (P) - and susceptibility to hepatocellular carcinoma (HCC) is controversial. Proline 153-160 tumor protein p53 Homo sapiens 84-88 23071787-6 2012 The frequency of somatic TP53 inactivation was 25.4% in Arg/Arg, 20.9% in Arg/Pro, and 16.7% in Pro/Pro patients, which may reflect a higher selective pressure to mutate the Arg-allele. Proline 78-81 tumor protein p53 Homo sapiens 25-29 23071787-6 2012 The frequency of somatic TP53 inactivation was 25.4% in Arg/Arg, 20.9% in Arg/Pro, and 16.7% in Pro/Pro patients, which may reflect a higher selective pressure to mutate the Arg-allele. Proline 96-99 tumor protein p53 Homo sapiens 25-29 23071787-6 2012 The frequency of somatic TP53 inactivation was 25.4% in Arg/Arg, 20.9% in Arg/Pro, and 16.7% in Pro/Pro patients, which may reflect a higher selective pressure to mutate the Arg-allele. Proline 96-99 tumor protein p53 Homo sapiens 25-29 21595775-4 2011 The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in EC were 39.4%, 45.6%, and 15.0%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively. Proline 60-63 tumor protein p53 Homo sapiens 19-22 22199295-7 2011 Individuals with the C (Pro) allele at p53 codon 72 had a 1.6-fold increased odds ratio of endometriosis, and those with Arg/Pro and Pro/Pro genotypes for p53 codon 72 had a 1.84- and 2.74-fold (95% confidence interval=1.17-2.92 and 1.58-4.74) increased risk of endometriosis compared to those with Arg/Arg, respectively. Proline 24-27 tumor protein p53 Homo sapiens 39-42 21595775-4 2011 The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in EC were 39.4%, 45.6%, and 15.0%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively. Proline 69-72 tumor protein p53 Homo sapiens 19-22 21595775-4 2011 The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in EC were 39.4%, 45.6%, and 15.0%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively. Proline 69-72 tumor protein p53 Homo sapiens 19-22 22057999-9 2011 Meta-analysis results showed that the Pro allele and Pro carrier (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism were significantly related with endometrial cancer risk (OR = 1.25, 95%CI = 1.10-1.41, P = 0.0005; OR = 1.34, 95%CI = 1.12-1.59, P = 0.001, respectively). Proline 39-42 tumor protein p53 Homo sapiens 89-92 21841506-7 2011 Pairwise combination analysis showed that patients carrying the variant P53 Pro/Pro-P73 GC/GC or P53 Pro/Pro-MDM2 GG genotypes had survival time only half of that for those carrying the wild-type genotypes, with hazard ratio being 2.47 (95% CI, 1.20-5.10) and 2.00 (95% CI, 1.15-3.46), respectively. Proline 76-79 tumor protein p53 Homo sapiens 72-75 22057999-9 2011 Meta-analysis results showed that the Pro allele and Pro carrier (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism were significantly related with endometrial cancer risk (OR = 1.25, 95%CI = 1.10-1.41, P = 0.0005; OR = 1.34, 95%CI = 1.12-1.59, P = 0.001, respectively). Proline 54-57 tumor protein p53 Homo sapiens 89-92 22057999-9 2011 Meta-analysis results showed that the Pro allele and Pro carrier (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism were significantly related with endometrial cancer risk (OR = 1.25, 95%CI = 1.10-1.41, P = 0.0005; OR = 1.34, 95%CI = 1.12-1.59, P = 0.001, respectively). Proline 54-57 tumor protein p53 Homo sapiens 89-92 22057999-11 2011 We concluded that the Pro allele (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism is a potential risk factor for endometrial cancer. Proline 23-26 tumor protein p53 Homo sapiens 57-60 22057999-11 2011 We concluded that the Pro allele (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism is a potential risk factor for endometrial cancer. Proline 39-42 tumor protein p53 Homo sapiens 57-60 22057999-11 2011 We concluded that the Pro allele (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism is a potential risk factor for endometrial cancer. Proline 39-42 tumor protein p53 Homo sapiens 57-60 20443084-11 2011 Our data show that proline homozygosity at p53 codon 72 is associated with decreased breast cancer risk in Arab women. Proline 19-26 tumor protein p53 Homo sapiens 43-46 21943426-8 2011 Further local structure analyses revealed that, guided by all-atom MD ensemble of fragments, the p53 N-terminal domain ensemble was biased to kinked structures in the AD1 region and biased to extended conformers in a proline-rich region and these biases contributed to improvement of the reproduction of the experiments. Proline 217-224 tumor protein p53 Homo sapiens 97-100 21316118-4 2011 The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in LC were 37.0%, 46.2%, and 16.7%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively (p<0.01). Proline 60-63 tumor protein p53 Homo sapiens 19-22 21316118-4 2011 The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in LC were 37.0%, 46.2%, and 16.7%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively (p<0.01). Proline 69-72 tumor protein p53 Homo sapiens 19-22 21316118-4 2011 The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in LC were 37.0%, 46.2%, and 16.7%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively (p<0.01). Proline 69-72 tumor protein p53 Homo sapiens 19-22 21461655-5 2011 RESULTS: The frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes of the p53 codon 72 polymorphism were 43.3, 42.0, and 13.0% in the gastric cancer patients; 40.5, 45.0, and 14.0% in the colorectal cancer patients; and 43.2, 45.6, and 11.2% in the controls, respectively. Proline 41-44 tumor protein p53 Homo sapiens 75-78 21843334-1 2011 BACKGROUND: Single-nucleotide polymorphisms within TP53 gene (codon 72 exon 4, rs1042522, encoding either arginine or proline) and MDM2 promoter (SNP309; rs2279744), have been independently associated with increased risk of several cancer types. Proline 118-125 tumor protein p53 Homo sapiens 51-55 21454683-1 2011 The common polymorphism of p53 at codon 72, either encoding proline or arginine, has drawn attention as a genetic factor associated with clinical outcome or cancer risk for the last 2 decades. Proline 60-67 tumor protein p53 Homo sapiens 27-30 21402718-3 2011 By using human p53 knockin (Hupki) mice carrying a single nucleotide polymorphism (SNP) at codon 72 (arginine/proline), the arginine allele was demonstrated to produce higher uterine LIF levels during implantation than the proline allele. Proline 110-117 tumor protein p53 Homo sapiens 15-18 21454683-3 2011 The arginine form (p53-72R) shows significantly enhanced phosphorylation at Ser-6 and Ser-20 compared with the proline form (p53-72P). Proline 111-118 tumor protein p53 Homo sapiens 19-22 21790217-3 2011 The ERE-linked p53 gene with the proline variant at codon 72 showed lower transfection rates than the gene without ERE or with the arginine variant at codon 72. Proline 33-40 tumor protein p53 Homo sapiens 15-18 21357744-3 2011 The p53 tumor suppressor protein, an important transcriptional regulator of apoptosis, naturally occurs in humans in two variants with single nucleotide polymorphisms resulting in Arg or Pro at residue 72. Proline 187-190 tumor protein p53 Homo sapiens 4-7 21043833-10 2011 Interactions of betel quid with p53 genotypes in lung cancer showed significant increase for all the three genotypes, indicating a major role of betel quid (OR=5.90, CI=1.67-20.81, p=0.006; OR=5.44, CI=1.67-17.75, p=0.005; and OR=5.84, CI=1.70-19.97, p=0.005 for Arg/Arg, Arg/Pro, and Pro/Pro, respectively). Proline 276-279 tumor protein p53 Homo sapiens 32-35 21043833-10 2011 Interactions of betel quid with p53 genotypes in lung cancer showed significant increase for all the three genotypes, indicating a major role of betel quid (OR=5.90, CI=1.67-20.81, p=0.006; OR=5.44, CI=1.67-17.75, p=0.005; and OR=5.84, CI=1.70-19.97, p=0.005 for Arg/Arg, Arg/Pro, and Pro/Pro, respectively). Proline 285-288 tumor protein p53 Homo sapiens 32-35 21043833-10 2011 Interactions of betel quid with p53 genotypes in lung cancer showed significant increase for all the three genotypes, indicating a major role of betel quid (OR=5.90, CI=1.67-20.81, p=0.006; OR=5.44, CI=1.67-17.75, p=0.005; and OR=5.84, CI=1.70-19.97, p=0.005 for Arg/Arg, Arg/Pro, and Pro/Pro, respectively). Proline 285-288 tumor protein p53 Homo sapiens 32-35 21123835-8 2011 We observed an association between TP53 alterations in the tumors and constitutive TP53 genotype (P < 0.01), with alterations preferentially occurring on the proline allele. Proline 161-168 tumor protein p53 Homo sapiens 35-39 21123835-8 2011 We observed an association between TP53 alterations in the tumors and constitutive TP53 genotype (P < 0.01), with alterations preferentially occurring on the proline allele. Proline 161-168 tumor protein p53 Homo sapiens 83-87 20419384-4 2011 PCR amplification for the analysis of p53 codon 72 arginine/proline alleles was carried out in a separate reaction. Proline 60-67 tumor protein p53 Homo sapiens 38-41 21598212-6 2011 PCR amplification of TP53 codon 72 polymorphism: TP53 codon 72 genotypes were detected by PCR using specific primer pairs for amplifying the proline or the arginine Alleles. Proline 141-148 tumor protein p53 Homo sapiens 21-25 21598212-6 2011 PCR amplification of TP53 codon 72 polymorphism: TP53 codon 72 genotypes were detected by PCR using specific primer pairs for amplifying the proline or the arginine Alleles. Proline 141-148 tumor protein p53 Homo sapiens 49-53 21598212-13 2011 In control samples, the genotype distribution for TP53 polymorphism showed 30.4%, 45.2% and 24.4% for the arginine/arginine, arginine/proline and proline/proline genotypes, respectively. Proline 134-141 tumor protein p53 Homo sapiens 50-54 21598212-13 2011 In control samples, the genotype distribution for TP53 polymorphism showed 30.4%, 45.2% and 24.4% for the arginine/arginine, arginine/proline and proline/proline genotypes, respectively. Proline 146-153 tumor protein p53 Homo sapiens 50-54 21598212-13 2011 In control samples, the genotype distribution for TP53 polymorphism showed 30.4%, 45.2% and 24.4% for the arginine/arginine, arginine/proline and proline/proline genotypes, respectively. Proline 146-153 tumor protein p53 Homo sapiens 50-54 22393962-7 2011 CONCLUSIONS: Our results suggest that the codon 72 SNP which results in amino acid substitution of Arginine to Proline in cell cycle regulatory gene P53, is associated with sporadic CRC risk and carriers of Pro/Pro genotype and more than 50 years old may have high susceptibility. Proline 111-118 tumor protein p53 Homo sapiens 149-152 21790217-5 2011 We consider that the presence of an upstream ERE promotes the transcriptional effects of the exogenous p53 gene with the proline variant, which strengthens the expression of p21, and results in lower transfection rates through cell cycle inhibition. Proline 121-128 tumor protein p53 Homo sapiens 103-106 21778786-0 2011 P53 codon 72 (Arg72Pro) polymorphism and prostate cancer risk: association between disease onset and proline genotype. Proline 101-108 tumor protein p53 Homo sapiens 0-3 20732856-4 2010 We observed an increased risk of cervical cancer associated with the p53 Arg/Arg (OR, 2.25; 95% CI, 1.11-4.54) or p21 Ser/Ser (OR, 2.09; 95% CI, 1.04-4.19) genotype, compared with the p53 Pro/Pro or p21 Arg/Arg genotype, respectively. Proline 188-191 tumor protein p53 Homo sapiens 69-72 21384570-2 2010 The p53 gene is characterized by Arg/Pro polymorphism in codon 72 whose alleles exhibit differential functional activity. Proline 37-40 tumor protein p53 Homo sapiens 4-7 20427142-1 2010 A common polymorphism at codon 72 of human TP53 gene determines a proline to arginine aminoacidic substitution within the proline-rich domain of p53 protein. Proline 66-73 tumor protein p53 Homo sapiens 43-47 20427142-1 2010 A common polymorphism at codon 72 of human TP53 gene determines a proline to arginine aminoacidic substitution within the proline-rich domain of p53 protein. Proline 66-73 tumor protein p53 Homo sapiens 145-148 20427142-1 2010 A common polymorphism at codon 72 of human TP53 gene determines a proline to arginine aminoacidic substitution within the proline-rich domain of p53 protein. Proline 122-129 tumor protein p53 Homo sapiens 43-47 20427142-1 2010 A common polymorphism at codon 72 of human TP53 gene determines a proline to arginine aminoacidic substitution within the proline-rich domain of p53 protein. Proline 122-129 tumor protein p53 Homo sapiens 145-148 20577877-1 2010 The TP53 tumor suppressor gene contains a well-studied polymorphism that encodes either proline (P) or arginine (R) at codon 72, and over half of the world"s population is homozygous for R at this codon. Proline 88-95 tumor protein p53 Homo sapiens 4-8 20732856-4 2010 We observed an increased risk of cervical cancer associated with the p53 Arg/Arg (OR, 2.25; 95% CI, 1.11-4.54) or p21 Ser/Ser (OR, 2.09; 95% CI, 1.04-4.19) genotype, compared with the p53 Pro/Pro or p21 Arg/Arg genotype, respectively. Proline 192-195 tumor protein p53 Homo sapiens 69-72 21103216-5 2010 Proline to alanine substitutions at P53, P481, P484, and P485 in the V42C background, as well as P53, P481, and P484 in the G489C background, exhibited decreased nucleotidase activities. Proline 0-7 tumor protein p53 Homo sapiens 36-39 20827430-4 2010 However, we found that the p53 Arg72Pro was associated with an increased risk of esophageal cancer ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.20, 95%CI=1.06-1.36) without any between-study heterogeneity. Proline 36-39 tumor protein p53 Homo sapiens 27-30 20827430-4 2010 However, we found that the p53 Arg72Pro was associated with an increased risk of esophageal cancer ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.20, 95%CI=1.06-1.36) without any between-study heterogeneity. Proline 101-104 tumor protein p53 Homo sapiens 27-30 20827430-4 2010 However, we found that the p53 Arg72Pro was associated with an increased risk of esophageal cancer ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.20, 95%CI=1.06-1.36) without any between-study heterogeneity. Proline 101-104 tumor protein p53 Homo sapiens 27-30 20827430-5 2010 In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity. Proline 117-120 tumor protein p53 Homo sapiens 108-111 20827430-5 2010 In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity. Proline 168-171 tumor protein p53 Homo sapiens 108-111 20827430-5 2010 In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity. Proline 168-171 tumor protein p53 Homo sapiens 108-111 20421238-6 2010 We identified a novel germ line variant of the 177 mutant (Pro to Arg; P177R) of p53 by genomic sequencing. Proline 59-62 tumor protein p53 Homo sapiens 81-84 20415579-3 2010 Matrix metalloproteinases degrading collagen are activated during stress to make proline available, and proline oxidase, the first enzyme in proline degradation, is induced by p53, peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands, and by AMP-activated protein kinase downregulating mTOR. Proline 104-111 tumor protein p53 Homo sapiens 176-179 20630574-8 2010 However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians. Proline 112-115 tumor protein p53 Homo sapiens 78-82 20630574-8 2010 However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians. Proline 116-119 tumor protein p53 Homo sapiens 78-82 20630574-8 2010 However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians. Proline 116-119 tumor protein p53 Homo sapiens 78-82 20630574-8 2010 However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians. Proline 116-119 tumor protein p53 Homo sapiens 78-82 20630574-8 2010 However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians. Proline 116-119 tumor protein p53 Homo sapiens 78-82 20389250-0 2010 Pro variant of TP53 Arg72Pro contributes to esophageal squamous cell carcinoma risk: evidence from a meta-analysis. Proline 0-3 tumor protein p53 Homo sapiens 15-19 20380571-4 2010 The frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes for P53 codon 72 were 51.7%, 41.4%, and 6.9% in patients and 42.6%, 47.3%, and 10.1% in controls, respectively. Proline 32-35 tumor protein p53 Homo sapiens 63-66 20380571-4 2010 The frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes for P53 codon 72 were 51.7%, 41.4%, and 6.9% in patients and 42.6%, 47.3%, and 10.1% in controls, respectively. Proline 41-44 tumor protein p53 Homo sapiens 63-66 21338227-2 2010 In the tumour suppressor Trp53 gene, a codon 72 polymorphism is frequent in the form of a single nucleotide polymorphism that leads to substitution of an arginine for a proline. Proline 169-176 tumor protein p53 Homo sapiens 25-30 20512840-3 2010 Actually, polymorphic variants Arg and Pro were found to have different properties of regulation of TP53-dependent DNA repair target genes, that can effect various levels of chromosome aberrations in cancer patients with these genotypes. Proline 39-42 tumor protein p53 Homo sapiens 100-104 20212049-7 2010 Furthermore, we showed that deletion of the basic domain enhances, whereas a mutation in activation domains 1-2 and deletion of the proline-rich domain abolish mutant p53 to regulate Gro1 and Id2, both of which are regulated by and mediate endogenous mutant p53 gain of function. Proline 132-139 tumor protein p53 Homo sapiens 167-170 20019240-0 2010 Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis. Proline 76-83 tumor protein p53 Homo sapiens 40-43 20019240-0 2010 Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis. Proline 76-83 tumor protein p53 Homo sapiens 98-101 20019240-4 2010 The largest difference between p53-arginine and p53-proline was found with the PERP gene involved in cell-cell adhesion and apoptosis. Proline 52-59 tumor protein p53 Homo sapiens 48-51 20019240-6 2010 LIF, a cytokine that is required for optimal reproductive function, was produced at 2x higher levels by the p53-arginine than the p53-proline allele. Proline 134-141 tumor protein p53 Homo sapiens 130-133 20019240-7 2010 The genes that induced their mRNAs at the highest levels compared to the baseline tended to be synthesized better by the p53-arginine protein than the p53-proline protein. Proline 155-162 tumor protein p53 Homo sapiens 151-154 21133638-5 2010 OBJECTIVE: The purpose of this study was to investigate the p53 polymorphism at codon 72 which results in encoding of either proline or arginine. Proline 125-132 tumor protein p53 Homo sapiens 60-63 19948747-4 2010 Since mutations in the p53 gene are present in approximately 40% of all human lung cancers and are more common in smokers than in nonsmokers, we aimed to detect the status of p53 at codon 72 for Arg/Arg or Arg/Pro or Pro/Pro allele polymorphism and p53 codon 249 mutation in smokers and nonsmokers of South India. Proline 210-213 tumor protein p53 Homo sapiens 175-178 19948747-4 2010 Since mutations in the p53 gene are present in approximately 40% of all human lung cancers and are more common in smokers than in nonsmokers, we aimed to detect the status of p53 at codon 72 for Arg/Arg or Arg/Pro or Pro/Pro allele polymorphism and p53 codon 249 mutation in smokers and nonsmokers of South India. Proline 210-213 tumor protein p53 Homo sapiens 175-178 20212049-5 2010 We also found that activation domains 1-2 and the proline-rich domain are required for mutant p53 gain of function. Proline 50-57 tumor protein p53 Homo sapiens 94-97 20658010-1 2010 UNLABELLED: p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg) or proline (Pro) in the protein p53 of codon 72. Proline 111-118 tumor protein p53 Homo sapiens 12-15 20658010-1 2010 UNLABELLED: p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg) or proline (Pro) in the protein p53 of codon 72. Proline 111-118 tumor protein p53 Homo sapiens 140-143 20658010-1 2010 UNLABELLED: p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg) or proline (Pro) in the protein p53 of codon 72. Proline 120-123 tumor protein p53 Homo sapiens 12-15 20658010-1 2010 UNLABELLED: p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg) or proline (Pro) in the protein p53 of codon 72. Proline 120-123 tumor protein p53 Homo sapiens 140-143 20193851-1 2010 Polymorphism at codon 72 of TP53, resulting in either the arginine (Arg) or proline (Pro) form of p53 (R72P), has been associated with the susceptibility to different cancers. Proline 76-83 tumor protein p53 Homo sapiens 28-32 20193851-1 2010 Polymorphism at codon 72 of TP53, resulting in either the arginine (Arg) or proline (Pro) form of p53 (R72P), has been associated with the susceptibility to different cancers. Proline 76-83 tumor protein p53 Homo sapiens 98-101 20193851-1 2010 Polymorphism at codon 72 of TP53, resulting in either the arginine (Arg) or proline (Pro) form of p53 (R72P), has been associated with the susceptibility to different cancers. Proline 85-88 tumor protein p53 Homo sapiens 28-32 20193851-1 2010 Polymorphism at codon 72 of TP53, resulting in either the arginine (Arg) or proline (Pro) form of p53 (R72P), has been associated with the susceptibility to different cancers. Proline 85-88 tumor protein p53 Homo sapiens 98-101 19786980-7 2010 Severe neutropenia was associated with the TP53 72 Pro/Pro, XPD 312 Asp/Asn and XRCC1 399 Arg/Arg genotypes. Proline 51-54 tumor protein p53 Homo sapiens 43-47 20082853-2 2010 To investigate the frequency of proline and arginine alleles of TP53 codon 72, the present study analyzed the DNA from blood samples of 30 Iranian women with endometrial cancer, in comparison with 32 healthy women. Proline 32-39 tumor protein p53 Homo sapiens 64-68 20414935-14 2010 Distribution of p53 gene mutations between Pro/Pro genotype and Arg/Pro plus Arg/Arg genotypes was not statistically significant. Proline 43-46 tumor protein p53 Homo sapiens 16-19 19576684-5 2010 These results suggest that a proline in position 72 of p53 increases the risk of cervical carcinoma in Chinese population. Proline 29-36 tumor protein p53 Homo sapiens 55-58 20130515-5 2010 RESULTS: Women homozygous for the p53 codon 72 Arg genotype were at a 5.6-fold higher risk for developing cervical intraepithelial neoplasia (CIN) 2 or 3 compared with those showing homozygosity for the Pro genotype or heterozygosity for the Pro/Arg genotype. Proline 203-206 tumor protein p53 Homo sapiens 34-37 19954513-0 2009 Identification of colorectal cancer patients with tumors carrying the TP53 mutation on the codon 72 proline allele that benefited most from 5-fluorouracil (5-FU) based postoperative chemotherapy. Proline 100-107 tumor protein p53 Homo sapiens 70-74 20563922-6 2010 The TP53 polymorphism distribution in this population was 64 (21.1%) Arg/Arg, 55 (18.1%) Pro/Pro, and 185 (60.9%) Arg/Pro. Proline 89-92 tumor protein p53 Homo sapiens 4-8 19521721-5 2009 Similarly, the alleles of rs1042522 in TP53 that encode arginine (G-allele) or proline (C-allele) at codon 72, which cause increased pro-apoptotic (G-allele) or cell-cycle arrest activities (C-allele), respectively, may moderate p53"s ability to prevent DNA damage. Proline 79-86 tumor protein p53 Homo sapiens 39-43 18853251-1 2009 The p53 tumor suppressor gene has a central role in the defense against cancer, including breast cancer, and contains a polymorphic variant (Arg/Pro) at codon 72 that has been shown to have different biological properties regarding apoptosis and cell cycle arrest. Proline 145-148 tumor protein p53 Homo sapiens 4-7 19423162-2 2009 A G-C exchange at p53 codon 72 polymorphism results in a substitution of proline (Pro) for arginine (Arg) in the transactivation domain, which was shown to alter the primary structure of the p53 protein. Proline 73-80 tumor protein p53 Homo sapiens 18-21 19423162-2 2009 A G-C exchange at p53 codon 72 polymorphism results in a substitution of proline (Pro) for arginine (Arg) in the transactivation domain, which was shown to alter the primary structure of the p53 protein. Proline 73-80 tumor protein p53 Homo sapiens 191-194 19423162-2 2009 A G-C exchange at p53 codon 72 polymorphism results in a substitution of proline (Pro) for arginine (Arg) in the transactivation domain, which was shown to alter the primary structure of the p53 protein. Proline 82-85 tumor protein p53 Homo sapiens 18-21 19423162-2 2009 A G-C exchange at p53 codon 72 polymorphism results in a substitution of proline (Pro) for arginine (Arg) in the transactivation domain, which was shown to alter the primary structure of the p53 protein. Proline 82-85 tumor protein p53 Homo sapiens 191-194 18930193-1 2009 OBJECTIVE: To determine whether the p53 codon 72 single nucleotide polymorphism, a change of the amino acid arginine (Arg) to proline (Pro) resulting from a single nucleotide mutation of guanine (G) to cytosine (C), has a clinically significant effect on implantation rate in fresh IVF cycles. Proline 126-133 tumor protein p53 Homo sapiens 36-39 18930193-1 2009 OBJECTIVE: To determine whether the p53 codon 72 single nucleotide polymorphism, a change of the amino acid arginine (Arg) to proline (Pro) resulting from a single nucleotide mutation of guanine (G) to cytosine (C), has a clinically significant effect on implantation rate in fresh IVF cycles. Proline 135-138 tumor protein p53 Homo sapiens 36-39 19764997-6 2009 Single nucleotide polymorphisms (SNPs) in TP53 (codon 72, arginine > proline) and MDM2 (SNP309, T > G) were genotyped using PCR-RFLP, and nuclear expression levels of p53 were examined using immunohistochemistry. Proline 72-79 tumor protein p53 Homo sapiens 42-46 19718045-5 2009 The proline-rich region (amino acids 64-91) of p53 was most likely responsible for the observed binding because a synthetic peptide comprising amino acids 68-81 of p53 inhibited this interaction, and a p53 variant containing a proline residue at position 72 (p53(P72)) interacted with Cyp18 more effectively than the corresponding p53(R72) variant. Proline 4-11 tumor protein p53 Homo sapiens 47-50 19718045-5 2009 The proline-rich region (amino acids 64-91) of p53 was most likely responsible for the observed binding because a synthetic peptide comprising amino acids 68-81 of p53 inhibited this interaction, and a p53 variant containing a proline residue at position 72 (p53(P72)) interacted with Cyp18 more effectively than the corresponding p53(R72) variant. Proline 4-11 tumor protein p53 Homo sapiens 164-167 19718045-5 2009 The proline-rich region (amino acids 64-91) of p53 was most likely responsible for the observed binding because a synthetic peptide comprising amino acids 68-81 of p53 inhibited this interaction, and a p53 variant containing a proline residue at position 72 (p53(P72)) interacted with Cyp18 more effectively than the corresponding p53(R72) variant. Proline 4-11 tumor protein p53 Homo sapiens 164-167 19718045-5 2009 The proline-rich region (amino acids 64-91) of p53 was most likely responsible for the observed binding because a synthetic peptide comprising amino acids 68-81 of p53 inhibited this interaction, and a p53 variant containing a proline residue at position 72 (p53(P72)) interacted with Cyp18 more effectively than the corresponding p53(R72) variant. Proline 4-11 tumor protein p53 Homo sapiens 164-167 19718045-5 2009 The proline-rich region (amino acids 64-91) of p53 was most likely responsible for the observed binding because a synthetic peptide comprising amino acids 68-81 of p53 inhibited this interaction, and a p53 variant containing a proline residue at position 72 (p53(P72)) interacted with Cyp18 more effectively than the corresponding p53(R72) variant. Proline 4-11 tumor protein p53 Homo sapiens 164-167 19718045-5 2009 The proline-rich region (amino acids 64-91) of p53 was most likely responsible for the observed binding because a synthetic peptide comprising amino acids 68-81 of p53 inhibited this interaction, and a p53 variant containing a proline residue at position 72 (p53(P72)) interacted with Cyp18 more effectively than the corresponding p53(R72) variant. Proline 227-234 tumor protein p53 Homo sapiens 47-50 19521721-5 2009 Similarly, the alleles of rs1042522 in TP53 that encode arginine (G-allele) or proline (C-allele) at codon 72, which cause increased pro-apoptotic (G-allele) or cell-cycle arrest activities (C-allele), respectively, may moderate p53"s ability to prevent DNA damage. Proline 79-86 tumor protein p53 Homo sapiens 229-232 19890497-1 2009 Pin1 specifically catalyzes the cis/trans isomerization of phospho-Ser/Thr-Pro bonds and plays an important role in many cellular events through the effects of conformational change on the function of its biological substrates, including cell division cycle 25 C (Cdc25C), c-Jun and p53. Proline 75-78 tumor protein p53 Homo sapiens 283-286 19448667-6 2009 We found a proline-rich region unique to BRG1 was required for binding to the histone acetyl transferase protein, CBP, as well as to p53. Proline 11-18 tumor protein p53 Homo sapiens 133-136 21475903-4 2009 Polymorphisms of TP53 include codon 72 containing either arginine (CGC) or proline (CCC). Proline 75-82 tumor protein p53 Homo sapiens 17-21 19654292-3 2009 Proline oxidase (POX), catalyzing the first step in proline catabolism, is induced by p53 and can regulate cell survival as well as mediate programmed cell death. Proline 52-59 tumor protein p53 Homo sapiens 86-89 19448667-7 2009 Ectopic expression of a proline-rich region deletion mutant BRG1 that is defective for CBP binding inhibited p53 destabilization. Proline 24-31 tumor protein p53 Homo sapiens 109-112 19470478-3 2009 The p53 allele encoding proline at codon 72 (P72) was found to be significantly enriched over the allele encoding arginine (R72) among in vitro fertilization (IVF) patients. Proline 24-31 tumor protein p53 Homo sapiens 4-7 19052714-4 2009 RESULTS: The Arg/Pro and Pro/Pro genotypes of TP53 codon 72 were significantly correlated with a lower response rate to the combination chemotherapy when compared to the Arg/Arg genotype (35.7 vs. 66.7%, P-value 0.019) in a logistic regression analysis. Proline 17-20 tumor protein p53 Homo sapiens 46-50 19052714-4 2009 RESULTS: The Arg/Pro and Pro/Pro genotypes of TP53 codon 72 were significantly correlated with a lower response rate to the combination chemotherapy when compared to the Arg/Arg genotype (35.7 vs. 66.7%, P-value 0.019) in a logistic regression analysis. Proline 25-28 tumor protein p53 Homo sapiens 46-50 19052714-4 2009 RESULTS: The Arg/Pro and Pro/Pro genotypes of TP53 codon 72 were significantly correlated with a lower response rate to the combination chemotherapy when compared to the Arg/Arg genotype (35.7 vs. 66.7%, P-value 0.019) in a logistic regression analysis. Proline 25-28 tumor protein p53 Homo sapiens 46-50 19052714-5 2009 A multivariate survival analysis also showed that the time to progression for the patients with the Arg/Pro and Pro/Pro genotypes of TP53 codon 72 was worse than for the patients with the Arg/Arg genotype (Hazard ratio = 3.056, P-value = 0.047), whereas the overall survival was not significantly different. Proline 104-107 tumor protein p53 Homo sapiens 133-137 19383811-7 2009 p53 Pro/Pro was strongly associated with shorter survival in the entire cohort (MS of 11.8 versus 29.1 months, P < 0.0001; adjusted hazard ratio for death, 2.05; 95% confidence interval, 1.30-3.24; P = 0.002 for Pro/Pro versus Arg/Arg). Proline 4-7 tumor protein p53 Homo sapiens 0-3 19451596-7 2009 Subjects carrying the TP53 Arg72Pro polymorphism were found to have a significantly increased death risk (Pro/Pro versus Arg/Arg; hazard ratio, 2.90; 95% CI, 1.28-6.66). Proline 32-35 tumor protein p53 Homo sapiens 22-26 19451596-7 2009 Subjects carrying the TP53 Arg72Pro polymorphism were found to have a significantly increased death risk (Pro/Pro versus Arg/Arg; hazard ratio, 2.90; 95% CI, 1.28-6.66). Proline 106-109 tumor protein p53 Homo sapiens 22-26 19451596-8 2009 In the subgroup of 130 high-grade osteosarcomas, the TP53 Arg72Pro was an independent marker of EFS (Pro/Pro versus Arg/Arg; hazard ratio, 2.67; 95% CI, 1.17-6.11). Proline 63-66 tumor protein p53 Homo sapiens 53-57 19451596-8 2009 In the subgroup of 130 high-grade osteosarcomas, the TP53 Arg72Pro was an independent marker of EFS (Pro/Pro versus Arg/Arg; hazard ratio, 2.67; 95% CI, 1.17-6.11). Proline 101-104 tumor protein p53 Homo sapiens 53-57 19383811-7 2009 p53 Pro/Pro was strongly associated with shorter survival in the entire cohort (MS of 11.8 versus 29.1 months, P < 0.0001; adjusted hazard ratio for death, 2.05; 95% confidence interval, 1.30-3.24; P = 0.002 for Pro/Pro versus Arg/Arg). Proline 8-11 tumor protein p53 Homo sapiens 0-3 19291875-2 2009 The p53 codon 72 Arg-Pro (CGC to CCC) polymorphism of exon 4 affects various biological properties; recently, it was reported that this polymorphism affects the ability to induce apoptosis in vitro. Proline 21-24 tumor protein p53 Homo sapiens 4-7 19434769-4 2009 p53 protein contains a transactivation domain, a sequence-specific DNA binding domain, a tetramerization domain, a non-specific DNA binding domain that recognizes damaged DNA, and a later identified proline-rich domain. Proline 199-206 tumor protein p53 Homo sapiens 0-3 23675098-3 2008 The TP53 codon 72 polymorphism is a single-nucleotide polymorphism (SNP) in exon 4, resulting in the expression of either arginine (CGC) or proline (CCC) residues. Proline 140-147 tumor protein p53 Homo sapiens 4-8 19940524-1 2009 OBJECTIVES: Several studies have examined the association of codon 72 polymorphism of the TP53 gene, encoding either arginine or proline, in several tumor types but none have investigated its role in Kaposi"s sarcoma (KS) development. Proline 129-136 tumor protein p53 Homo sapiens 90-94 18058229-6 2008 However, combined analysis of the SNP"s showed that p53 (Arg/Arg and Arg/Pro) with TGFbeta1 (Pro/Pro and Leu/Pro) were associated with greater than 2 fold increased risk for breast cancer in Univariate (P=0.01) and Multivariate (P=0.003) analysis. Proline 73-76 tumor protein p53 Homo sapiens 52-55 19137883-9 2008 RESULTS: The genetic genotype of p53 gene codon 72 in keloids included Arg/Arg in 7 cases, Pro/Arg in 21 cases, Pro/ Pro in 7 cases. Proline 91-94 tumor protein p53 Homo sapiens 33-36 19137883-9 2008 RESULTS: The genetic genotype of p53 gene codon 72 in keloids included Arg/Arg in 7 cases, Pro/Arg in 21 cases, Pro/ Pro in 7 cases. Proline 112-115 tumor protein p53 Homo sapiens 33-36 19137883-9 2008 RESULTS: The genetic genotype of p53 gene codon 72 in keloids included Arg/Arg in 7 cases, Pro/Arg in 21 cases, Pro/ Pro in 7 cases. Proline 112-115 tumor protein p53 Homo sapiens 33-36 18707164-2 2008 The result of the calculation, based on structures from nanosecond molecular dynamics simulation, revealed that (19)Phe, (22)Leu, and (23)Trp of p53 have the strongest binding interaction with MDM2 followed by (26)Leu and (27)Pro. Proline 226-229 tumor protein p53 Homo sapiens 145-148 18781154-2 2008 Specifically, two polymorphisms in p53, c.97-147ins16bp and p.Arg72Pro have been analysed as putative breast cancer susceptibility variants, and it has been recently reported that a p53 haplotype combining the absence of the 16-bp insertion and the presence of proline at codon 72 (No Ins-72Pro) was associated with an earlier age at the onset of the first primary tumour in BRCA2 mutation carriers in the Spanish population. Proline 261-268 tumor protein p53 Homo sapiens 35-38 18781154-2 2008 Specifically, two polymorphisms in p53, c.97-147ins16bp and p.Arg72Pro have been analysed as putative breast cancer susceptibility variants, and it has been recently reported that a p53 haplotype combining the absence of the 16-bp insertion and the presence of proline at codon 72 (No Ins-72Pro) was associated with an earlier age at the onset of the first primary tumour in BRCA2 mutation carriers in the Spanish population. Proline 261-268 tumor protein p53 Homo sapiens 182-185 18355840-9 2008 In p53 codon72 Arg/Pro + Pro/Pro carriers the frequency of the AG + GG genotype of MSH3 exon23 was significantly increased in patients compared to controls (OR 2.1, 95% CI 1.05-4.34). Proline 19-22 tumor protein p53 Homo sapiens 3-6 18758421-2 2008 A common polymorphism at codon 72 of exon 4 of the p53 gene encoding either an arginine or proline has been shown to confer susceptibility to the development of different human malignancies. Proline 91-98 tumor protein p53 Homo sapiens 51-54 18390844-7 2008 Multivariate analysis for the presence of HCC revealed that the odds ratio (OR) for MDM2 G/G over T/T was 4.89 (P < 0.001) and that of p53 Pro/Pro over Arg/Arg was 3.03 (P = 0.006). Proline 142-145 tumor protein p53 Homo sapiens 138-141 18510673-6 2008 RESULTS: We found that the p53 Proline (Pro) allele was positively associated with childhood tanning response only among black/dark brown-haired women. Proline 31-38 tumor protein p53 Homo sapiens 27-30 18490454-6 2008 Moreover, Cdk5 (cyclin-dependent kinase 5), a proline-directed Ser/Thr kinase, additionally increases p53 stability via post-translational modification of p53 in response to hydrogen peroxide. Proline 46-53 tumor protein p53 Homo sapiens 102-105 18490454-6 2008 Moreover, Cdk5 (cyclin-dependent kinase 5), a proline-directed Ser/Thr kinase, additionally increases p53 stability via post-translational modification of p53 in response to hydrogen peroxide. Proline 46-53 tumor protein p53 Homo sapiens 155-158 18348141-1 2008 In vitro studies suggest that p53 codon 72 genotype alters the apoptotic capacity of p53 protein, with the 72 arginine (R) form of wild-type p53 harboring a greater apoptosis-inducing potential than the 72 proline (P) variant. Proline 206-213 tumor protein p53 Homo sapiens 30-33 18348141-1 2008 In vitro studies suggest that p53 codon 72 genotype alters the apoptotic capacity of p53 protein, with the 72 arginine (R) form of wild-type p53 harboring a greater apoptosis-inducing potential than the 72 proline (P) variant. Proline 206-213 tumor protein p53 Homo sapiens 85-88 18348141-1 2008 In vitro studies suggest that p53 codon 72 genotype alters the apoptotic capacity of p53 protein, with the 72 arginine (R) form of wild-type p53 harboring a greater apoptosis-inducing potential than the 72 proline (P) variant. Proline 206-213 tumor protein p53 Homo sapiens 85-88 18355840-9 2008 In p53 codon72 Arg/Pro + Pro/Pro carriers the frequency of the AG + GG genotype of MSH3 exon23 was significantly increased in patients compared to controls (OR 2.1, 95% CI 1.05-4.34). Proline 25-28 tumor protein p53 Homo sapiens 3-6 18355840-9 2008 In p53 codon72 Arg/Pro + Pro/Pro carriers the frequency of the AG + GG genotype of MSH3 exon23 was significantly increased in patients compared to controls (OR 2.1, 95% CI 1.05-4.34). Proline 25-28 tumor protein p53 Homo sapiens 3-6 18215142-0 2008 The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning. Proline 29-36 tumor protein p53 Homo sapiens 141-144 18423915-4 2008 A G-to-C SNP at p53 codon 72 results in an Arg/Pro polymorphism, which is associated with apoptosis induction potential and p53 mutation status. Proline 47-50 tumor protein p53 Homo sapiens 16-19 18423915-4 2008 A G-to-C SNP at p53 codon 72 results in an Arg/Pro polymorphism, which is associated with apoptosis induction potential and p53 mutation status. Proline 47-50 tumor protein p53 Homo sapiens 124-127 18414047-8 2008 An association has been reported between women carrying the p53 codon 72 polymorphism (a proline to arginine change) with recurrent implantation failure, suggesting a similar function for p53 in humans. Proline 89-96 tumor protein p53 Homo sapiens 60-63 18414047-8 2008 An association has been reported between women carrying the p53 codon 72 polymorphism (a proline to arginine change) with recurrent implantation failure, suggesting a similar function for p53 in humans. Proline 89-96 tumor protein p53 Homo sapiens 188-191 17998932-1 2008 Codon 72 of human p53 gene is polymorphic, encoding arginine or proline. Proline 64-71 tumor protein p53 Homo sapiens 18-21 18215142-0 2008 The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning. Proline 29-36 tumor protein p53 Homo sapiens 77-80 18215142-4 2008 In the present study, using phage display, sitedirected mutagenesis, pulldown and immunoprecipitation assays we localized the site of FAK binding to a 7-amino-acid region(amino acids 65-71) in the N-terminal proline-rich domain of human p53. Proline 208-215 tumor protein p53 Homo sapiens 237-240 19065769-3 2008 TP53 codon 72 polymorphism results in either the arginine or proline form of the p53 protein; several studies have investigated whether codon 72 polymorphisms are risk and prognostic factors for cancer. Proline 61-68 tumor protein p53 Homo sapiens 0-4 18272203-2 2008 In humans, we recently found that a TP53 codon 72 Arginine (Arg) to Proline (Pro) polymorphism affected both cancer incidence and longevity as well. Proline 68-75 tumor protein p53 Homo sapiens 36-40 18272203-2 2008 In humans, we recently found that a TP53 codon 72 Arginine (Arg) to Proline (Pro) polymorphism affected both cancer incidence and longevity as well. Proline 68-71 tumor protein p53 Homo sapiens 36-40 18288414-2 2008 Several reports have focused on p53 polymorphisms as risk factors in lung cancer, in particular at codon 72 of exon 4, encoding either an arginine (Arg72R) or a proline (Pro72P) amino acid. Proline 161-168 tumor protein p53 Homo sapiens 32-35 19065769-3 2008 TP53 codon 72 polymorphism results in either the arginine or proline form of the p53 protein; several studies have investigated whether codon 72 polymorphisms are risk and prognostic factors for cancer. Proline 61-68 tumor protein p53 Homo sapiens 81-84 18803266-0 2008 p53 codon 72 proline/arginine polymorphism and autoimmune thyroid diseases. Proline 13-20 tumor protein p53 Homo sapiens 0-3 18803266-8 2008 The p53 codon 72 proline/arginine polymorphism may be a genetic marker to predict the increased susceptibility of development of HT. Proline 17-24 tumor protein p53 Homo sapiens 4-7 17504512-4 2007 The polymorphism on p53, which encodes either a proline or an arginine amino acid residue at codon 72, has been reported as a possible risk factor for cervical disease. Proline 48-55 tumor protein p53 Homo sapiens 20-23 17906639-5 2007 Accordingly, tumor-associated mutations at Pin1-binding residues within the p53 proline-rich domain hamper acetylation of p53 by p300. Proline 80-87 tumor protein p53 Homo sapiens 76-79 17906639-5 2007 Accordingly, tumor-associated mutations at Pin1-binding residues within the p53 proline-rich domain hamper acetylation of p53 by p300. Proline 80-87 tumor protein p53 Homo sapiens 122-125 17767549-0 2007 Predisposition to HPV16/18-related cervical cancer because of proline homozygosity at codon 72 of p53 among Indian women is influenced by HLA-B*07 and homozygosity of HLA-DQB1*03. Proline 62-69 tumor protein p53 Homo sapiens 98-101 17300219-6 2007 The N-terminal domain of MAML1 contains a proline repeat motif (PXPAAPAP) that was previously shown to be present in p53 and important for the p300-p53 interaction. Proline 42-49 tumor protein p53 Homo sapiens 117-120 18670615-5 2008 Previous studies showed that proline oxidase is a p53-induced gene and its overexpression can initiate proline-dependent apoptosis by both intrinsic and extrinsic pathways. Proline 29-36 tumor protein p53 Homo sapiens 50-53 18612219-1 2008 BACKGROUND: The p53 codon 72 polymorphism, which results in either an arginine or proline residue, plays a different role in vitro and in vivo in cell survival and drug resistance. Proline 82-89 tumor protein p53 Homo sapiens 16-19 17653713-3 2007 On the other hand, a common polymorphism of the tumour suppressor P53 gene results in either arginine (A) or proline (P) at amino-acid position 72. Proline 109-116 tumor protein p53 Homo sapiens 66-69 17954263-0 2007 Proline homozygosity in codon 72 of TP53 is a factor of susceptibility to nasopharyngeal carcinoma in Tunisia. Proline 0-7 tumor protein p53 Homo sapiens 36-40 17954263-1 2007 A common polymorphism at codon 72 of TP53, the gene encoding the tumor suppressor protein p53, encodes either arginine or proline. Proline 122-129 tumor protein p53 Homo sapiens 37-41 17954263-1 2007 A common polymorphism at codon 72 of TP53, the gene encoding the tumor suppressor protein p53, encodes either arginine or proline. Proline 122-129 tumor protein p53 Homo sapiens 90-93 17492690-2 2007 The TP53 polymorphism, in which an arginine (R) is changed to proline (P) at codon 72, is functionally significant and could therefore be a predisposing genetic defect. Proline 62-69 tumor protein p53 Homo sapiens 4-8 16973168-4 2007 The high-arsenic exposure group with GSTP1 variant genotypes of Ile/Val and Val/Val, and with the p53 variant genotypes of Arg/Pro and Pro/Pro had 6.0- and 3.1-fold higher risks of carotid atherosclerosis, respectively. Proline 127-130 tumor protein p53 Homo sapiens 98-101 16973168-4 2007 The high-arsenic exposure group with GSTP1 variant genotypes of Ile/Val and Val/Val, and with the p53 variant genotypes of Arg/Pro and Pro/Pro had 6.0- and 3.1-fold higher risks of carotid atherosclerosis, respectively. Proline 135-138 tumor protein p53 Homo sapiens 98-101 16973168-4 2007 The high-arsenic exposure group with GSTP1 variant genotypes of Ile/Val and Val/Val, and with the p53 variant genotypes of Arg/Pro and Pro/Pro had 6.0- and 3.1-fold higher risks of carotid atherosclerosis, respectively. Proline 135-138 tumor protein p53 Homo sapiens 98-101 17671760-2 2007 The proapoptotic activity of p53 seems to be strictly related to proline-rich regions, homologous to the SH3 binding domain. Proline 65-72 tumor protein p53 Homo sapiens 29-32 17631738-2 2007 The wild type p53 protein presents a common polymorphism at position 72 resulting in either a proline or an arginine residue at this position, leading to differences between the two variants in the induction of apoptosis. Proline 94-101 tumor protein p53 Homo sapiens 14-17 17403527-1 2007 A very common polymorphism of p53, that of codon 72, codes either for a proline (P72) or an arginine (R72). Proline 72-79 tumor protein p53 Homo sapiens 30-33 17631738-7 2007 All of the RA patients and controls were genotyped by the polymerase chain reaction and allele-specific oligonucleotide techniques for p53 gene polymorphism Arg/Pro at codon 72. Proline 161-164 tumor protein p53 Homo sapiens 135-138 17208332-1 2007 The TP53 gene has a polymorphism in exon 4 at codon 72 that presents the arginine or proline genotype. Proline 85-92 tumor protein p53 Homo sapiens 4-8 17599946-1 2007 A TP53 gene polymorphism, resulting in an arginine (R) to proline (P) at codon 72 (TP53 R72P), has been associated with the susceptibility to various cancers. Proline 58-65 tumor protein p53 Homo sapiens 2-6 17599946-1 2007 A TP53 gene polymorphism, resulting in an arginine (R) to proline (P) at codon 72 (TP53 R72P), has been associated with the susceptibility to various cancers. Proline 58-65 tumor protein p53 Homo sapiens 83-87 17223878-1 2007 BACKGROUND: p53 has a common polymorphism at amino acid 72, encoding either arginine or proline. Proline 88-95 tumor protein p53 Homo sapiens 12-15 17406354-0 2007 The p53 codon 72 proline allele is endowed with enhanced cell-death inducing potential in cancer cells exposed to hypoxia. Proline 17-24 tumor protein p53 Homo sapiens 4-7 17406354-1 2007 The preferential retention of the arginine allele at the p53 codon 72 locus is commonly observed in tumours from arginine/proline heterozygotes. Proline 122-129 tumor protein p53 Homo sapiens 57-60 17406354-2 2007 Considering that cancer cells are harboured in a hypoxic environment in vivo, we here tested the hypothesis that the p53 codon 72 proline allele confers a survival disadvantage in presence of hypoxia. Proline 130-137 tumor protein p53 Homo sapiens 117-120 17406354-3 2007 Here, we show that the transient transfection of the proline allele in p53 null cancer cells exposed to low oxygen tension or to the hypoxia-mimetic drug Desferoxamine induces a higher amount of cell death than the arginine allele. Proline 53-60 tumor protein p53 Homo sapiens 71-74 17406354-6 2007 These data indicate that the p53 codon 72 proline allele is less permissive for the growth of cancer cells in a hypoxic environment, and suggest that the preferential retention of the arginine allele in the tumour tissues of arginine/proline heterozygous patients may depend upon its lowered capacity to induce cell death in a hypoxic tumour environment. Proline 42-49 tumor protein p53 Homo sapiens 29-32 17406354-6 2007 These data indicate that the p53 codon 72 proline allele is less permissive for the growth of cancer cells in a hypoxic environment, and suggest that the preferential retention of the arginine allele in the tumour tissues of arginine/proline heterozygous patients may depend upon its lowered capacity to induce cell death in a hypoxic tumour environment. Proline 234-241 tumor protein p53 Homo sapiens 29-32 17319790-11 2007 In the younger women group, the p53 BstUI polymorphism genotype frequencies were 6.2% for BstUIPro/Pro, 31.0% for BstUIArg/Pro and 62.8% for BstUIArg/Arg in controls and 11.11 %, 40.74% and 48.15% in cases respectively. Proline 95-98 tumor protein p53 Homo sapiens 32-35 17094395-1 2006 BACKGROUND: The oncoprotein E6 binds to and degrades the p53 tumor suppressor protein, with different efficacy depending on the p53 codon 72 (arg/pro) polymorphism. Proline 20-23 tumor protein p53 Homo sapiens 57-60 16721787-3 2006 Among 856 colorectal adenoma cases and 1,184 controls, we observed a modest association with p53 Arg72Pro genotype (multivariate odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.04-1.50 for Arg/Pro and Pro/Pro vs. Arg/Arg). Proline 102-105 tumor protein p53 Homo sapiens 93-96 16721787-3 2006 Among 856 colorectal adenoma cases and 1,184 controls, we observed a modest association with p53 Arg72Pro genotype (multivariate odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.04-1.50 for Arg/Pro and Pro/Pro vs. Arg/Arg). Proline 202-205 tumor protein p53 Homo sapiens 93-96 16721787-3 2006 Among 856 colorectal adenoma cases and 1,184 controls, we observed a modest association with p53 Arg72Pro genotype (multivariate odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.04-1.50 for Arg/Pro and Pro/Pro vs. Arg/Arg). Proline 202-205 tumor protein p53 Homo sapiens 93-96 16964264-0 2006 iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53. Proline 31-38 tumor protein p53 Homo sapiens 27-30 16964264-2 2006 We show here that, in addition to the DNA-binding domain, the ASPP family members also bind to the proline-rich region of p53, which contains the most common p53 polymorphism at codon 72. Proline 99-106 tumor protein p53 Homo sapiens 122-125 16964264-2 2006 We show here that, in addition to the DNA-binding domain, the ASPP family members also bind to the proline-rich region of p53, which contains the most common p53 polymorphism at codon 72. Proline 99-106 tumor protein p53 Homo sapiens 158-161 17123452-6 2006 When evaluated by several pathway and biological process analysis programs, these proteins are demonstrated to be involved with a high degree of confidence (p values < 2.0 E-05) in glycolysis, propanoate metabolism, pyruvate metabolism, urea cycle and arginine/proline metabolism, as well as in the non-metabolic p53 and FAS pathways. Proline 264-271 tumor protein p53 Homo sapiens 316-319 17094395-1 2006 BACKGROUND: The oncoprotein E6 binds to and degrades the p53 tumor suppressor protein, with different efficacy depending on the p53 codon 72 (arg/pro) polymorphism. Proline 20-23 tumor protein p53 Homo sapiens 128-131 16697770-9 2006 Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033]. Proline 51-54 tumor protein p53 Homo sapiens 47-50 16835507-3 2006 We evaluated the linkage of the polymorphic variants (Arg/Pro) on TP53 codon 72 with nasopharyngeal cancer development in a case-control study with 392 individuals from a northern Portuguese population, including 107 patients with nasopharyngeal carcinoma and 285 healthy controls. Proline 58-61 tumor protein p53 Homo sapiens 66-70 16786124-1 2006 The TP53 polymorphism occurs at codon 72 of exon 4 with two alleles encoding either arginine or proline. Proline 96-103 tumor protein p53 Homo sapiens 4-8 16462765-3 2006 A polymorphic site at codon 72 in exon 4 encodes either an arginine amino acid (Trp53(72R)) or a proline residue (Trp53(72P)). Proline 97-104 tumor protein p53 Homo sapiens 114-119 16697770-9 2006 Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033]. Proline 55-58 tumor protein p53 Homo sapiens 47-50 16697770-9 2006 Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033]. Proline 55-58 tumor protein p53 Homo sapiens 47-50 16318864-11 2006 There was also a higher incidence of, but without reaching a statistical significance, p53 mutation in patients with p53 overexpression (OR[95% CI]: 2.18 [0.52-9.6]) and codon 72 Arg/Arg genotype (OR [95% CI] of 0.8 [0.13-4.2], comparing genotypes of Pro/Pro and Arg/Pro with Arg/Arg). Proline 251-254 tumor protein p53 Homo sapiens 87-90 16314399-6 2006 Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction). Proline 97-100 tumor protein p53 Homo sapiens 88-91 16314399-6 2006 Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction). Proline 97-100 tumor protein p53 Homo sapiens 222-225 16314399-6 2006 Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction). Proline 232-235 tumor protein p53 Homo sapiens 88-91 16499995-11 2006 Somatic TP53 mutations were found in 62 out of 240 NSCLC patients (26%), more frequently in Pro carriers (31%) than in Arg homozygotes (20%, p = 0.06). Proline 92-95 tumor protein p53 Homo sapiens 8-12 16646561-2 2006 The codon 72 polymorphism on exon 4 in the p53 gene produces variant proteins with either arginine (Arg) or proline (Pro), and is associated with an increased susceptibility of cancers of the lung, esophagus, breast, cervix and nasopharynx on a genetic basis. Proline 108-115 tumor protein p53 Homo sapiens 43-46 16646561-2 2006 The codon 72 polymorphism on exon 4 in the p53 gene produces variant proteins with either arginine (Arg) or proline (Pro), and is associated with an increased susceptibility of cancers of the lung, esophagus, breast, cervix and nasopharynx on a genetic basis. Proline 117-120 tumor protein p53 Homo sapiens 43-46 16498444-3 2006 The identification of a new family of proteins, known as ASPPs (ankyrin-repeat-, SH3-domain- and proline-rich-region-containing proteins), has led to the discovery of a novel mechanism that selectively regulates the apoptotic function, but not the cell-cycle-arrest function, of p53, and gives an insight into how p53 responds to different stress signals. Proline 97-104 tumor protein p53 Homo sapiens 279-282 16498444-3 2006 The identification of a new family of proteins, known as ASPPs (ankyrin-repeat-, SH3-domain- and proline-rich-region-containing proteins), has led to the discovery of a novel mechanism that selectively regulates the apoptotic function, but not the cell-cycle-arrest function, of p53, and gives an insight into how p53 responds to different stress signals. Proline 97-104 tumor protein p53 Homo sapiens 314-317 16318864-11 2006 There was also a higher incidence of, but without reaching a statistical significance, p53 mutation in patients with p53 overexpression (OR[95% CI]: 2.18 [0.52-9.6]) and codon 72 Arg/Arg genotype (OR [95% CI] of 0.8 [0.13-4.2], comparing genotypes of Pro/Pro and Arg/Pro with Arg/Arg). Proline 255-258 tumor protein p53 Homo sapiens 87-90 16318864-11 2006 There was also a higher incidence of, but without reaching a statistical significance, p53 mutation in patients with p53 overexpression (OR[95% CI]: 2.18 [0.52-9.6]) and codon 72 Arg/Arg genotype (OR [95% CI] of 0.8 [0.13-4.2], comparing genotypes of Pro/Pro and Arg/Pro with Arg/Arg). Proline 255-258 tumor protein p53 Homo sapiens 87-90 16699611-4 2006 AIM: To investigate the possible association between p53 arginine/72 proline polymorphism and susceptibility to colorectal cancer. Proline 69-76 tumor protein p53 Homo sapiens 53-56 16362795-2 2005 TP53 codon 72, which produces variant proteins with an arginine (Arg) or proline (Pro), has been reported to be associated with cancers of the lung, oesophagus, stomach and cervix. Proline 73-80 tumor protein p53 Homo sapiens 0-4 17113725-1 2006 BACKGROUND: A common Arg/Pro polymorphism at codon 72 of the TP53 gene has been investigated as a risk factor for cancer in different populations. Proline 25-28 tumor protein p53 Homo sapiens 61-65 16168468-3 2006 RESULTS: When p53 codon 72 genotype was classified into two subgroups of Arg/Arg and Arg/Pro + Pro/Pro, the Arg/Arg genotype was associated with an increased risk for the development of endometrial cancer (OR = 1.86, 95% CI = 1.06 to 3.26) compared with the Arg/Pro + Pro/Pro genotype (P = 0.0301). Proline 89-92 tumor protein p53 Homo sapiens 14-17 16362795-2 2005 TP53 codon 72, which produces variant proteins with an arginine (Arg) or proline (Pro), has been reported to be associated with cancers of the lung, oesophagus, stomach and cervix. Proline 82-85 tumor protein p53 Homo sapiens 0-4 16203772-1 2005 PURPOSE: The Arg/Pro polymorphism in codon 72 of p53 was recently associated with age of onset of colorectal cancer in Lynch syndrome. Proline 17-20 tumor protein p53 Homo sapiens 49-52 16307686-2 2005 Furthermore, the polymorphism at codon 72 (encoding either arginine or proline) of the p53 tumor-suppressor gene is discussed as a possible determinant for cancer risk. Proline 71-78 tumor protein p53 Homo sapiens 87-90 16123044-6 2005 In this regard, it has been recently observed that the prolyl isomerase Pin1 can interact with proteins phosphorylated on serine or threonine residues that precede prolines (pS/T-P), such as the transcription factors p53 and c-Jun, thereby controlling their activity by promoting the cis-trans isomerization of these pS/T-P bonds. Proline 164-172 tumor protein p53 Homo sapiens 217-220 16243804-9 2005 CONCLUSION: Our study indicates that breast cancer patients with the Pro/Pro variant may be less sensitive to anthracycline-based treatment than those with the Pro/Arg or Arg/Arg variant and suggests that analysis of p53 codon 72 polymorphism may provide a simple predictive marker for selecting the right breast cancer patients to anthracycline-based neoadjuvant chemotherapy in clinical setting. Proline 69-72 tumor protein p53 Homo sapiens 217-220 15905205-7 2005 Importantly, patient survival did significantly differ: those patients having a TP53 mutation on the proline allele had the worst survival outcomes (hazards ratio = 2.6, P < 0.03). Proline 101-108 tumor protein p53 Homo sapiens 80-84 15905205-9 2005 Our data suggest that there are selective pressures for loss of the TP53 proline allele in non-small cell lung cancer. Proline 73-80 tumor protein p53 Homo sapiens 68-72 16140998-8 2005 CONCLUSIONS: The p53 codon 72 Arg/Pro polymorphism is not associated with age of onset or severity of glaucoma. Proline 34-37 tumor protein p53 Homo sapiens 17-20 16054204-4 2005 RESULTS: The observed association of proline homozygosity at codon 72 of p53 with CaCx infection (Bhattacharya, P., Duttagupta, C., Sengupta, S. 2002.Proline homozygosity in codon 72 of p53: A risk genotype for Human Papillomavirus related cervical cancer in Indian women. Proline 37-44 tumor protein p53 Homo sapiens 73-76 16054204-4 2005 RESULTS: The observed association of proline homozygosity at codon 72 of p53 with CaCx infection (Bhattacharya, P., Duttagupta, C., Sengupta, S. 2002.Proline homozygosity in codon 72 of p53: A risk genotype for Human Papillomavirus related cervical cancer in Indian women. Proline 37-44 tumor protein p53 Homo sapiens 186-189 16054204-4 2005 RESULTS: The observed association of proline homozygosity at codon 72 of p53 with CaCx infection (Bhattacharya, P., Duttagupta, C., Sengupta, S. 2002.Proline homozygosity in codon 72 of p53: A risk genotype for Human Papillomavirus related cervical cancer in Indian women. Proline 150-157 tumor protein p53 Homo sapiens 73-76 16054204-4 2005 RESULTS: The observed association of proline homozygosity at codon 72 of p53 with CaCx infection (Bhattacharya, P., Duttagupta, C., Sengupta, S. 2002.Proline homozygosity in codon 72 of p53: A risk genotype for Human Papillomavirus related cervical cancer in Indian women. Proline 150-157 tumor protein p53 Homo sapiens 186-189 16054204-8 2005 The p21 arginine allele was significantly associated with CaCx in the p53 proline non-homozygous group of subjects (OR(age-adjusted) = 2.68; 95% CI: 1.21-5.91; P = 0.01), and specifically in the p53 heterozygous group (OR(age-adjusted) = 2.91; 95% CI = 1.12-7.56; P = 0.03). Proline 74-81 tumor protein p53 Homo sapiens 70-73 16054204-10 2005 However, the two risk factors, p53 proline homozygosity and p21 arginine allele, although part of a common causal pathway, appear to act in a mutually exclusive manner. Proline 35-42 tumor protein p53 Homo sapiens 31-34 16082224-1 2005 A common polymorphism at codon 72 in p53 gene leads to an arginine to proline aminoacidic substitution which affects in an age-dependent manner the susceptibility of cells to undergo apoptosis after oxidative stress. Proline 70-77 tumor protein p53 Homo sapiens 37-40 16199549-1 2005 The polymorphic variants at codon 72 of the p53 gene were shown to be functionally distinct in vitro, whereby the arginine (arg) variant induces apoptosis more efficiently than the proline (pro) variant. Proline 181-188 tumor protein p53 Homo sapiens 44-47 16172238-1 2005 Polymorphism at codon 72 of p53 results in either the arginine or proline form of p53, whose functional significance in carcinogenesis is controversial. Proline 66-73 tumor protein p53 Homo sapiens 28-31 16172238-1 2005 Polymorphism at codon 72 of p53 results in either the arginine or proline form of p53, whose functional significance in carcinogenesis is controversial. Proline 66-73 tumor protein p53 Homo sapiens 82-85 16172238-2 2005 We have investigated if the expression of these p53 polymorphs is selectively regulated, using mRNA from peripheral blood of healthy Asian (Chinese) and the Caucasian (Polish) arginine/proline (arg/pro) heterozygote subjects. Proline 185-192 tumor protein p53 Homo sapiens 48-51 16172238-2 2005 We have investigated if the expression of these p53 polymorphs is selectively regulated, using mRNA from peripheral blood of healthy Asian (Chinese) and the Caucasian (Polish) arginine/proline (arg/pro) heterozygote subjects. Proline 185-188 tumor protein p53 Homo sapiens 48-51 15964795-5 2005 Proline 82 of p53 was identified to be essential for its interaction with the checkpoint kinase 2 (Chk2) and consequent phosphorylation of p53 on serine 20, following DNA damage. Proline 0-7 tumor protein p53 Homo sapiens 14-17 16109171-1 2005 BACKGROUND: A common sequence polymorphism at codon 72 of the p53 gene encoding either arginine or proline was recently shown to be functionally relevant for apoptosis induction in vitro. Proline 99-106 tumor protein p53 Homo sapiens 62-65 15964795-0 2005 Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage. Proline 13-20 tumor protein p53 Homo sapiens 27-30 15964795-5 2005 Proline 82 of p53 was identified to be essential for its interaction with the checkpoint kinase 2 (Chk2) and consequent phosphorylation of p53 on serine 20, following DNA damage. Proline 0-7 tumor protein p53 Homo sapiens 139-142 15814626-0 2005 The p53 codon 72 proline allele is associated with p53 gene mutations in non-small cell lung cancer. Proline 17-24 tumor protein p53 Homo sapiens 4-7 15966238-0 2005 Arginine and proline alleles of the p53 gene are associated with different locations of gastric cancer. Proline 13-20 tumor protein p53 Homo sapiens 36-39 15966238-14 2005 CONCLUSIONS: The proline allele at p53 codon 72 is associated with adenocarcinoma of the gastric cardia, and the arginine allele is associated with cancer of the antral and corpus locations. Proline 17-24 tumor protein p53 Homo sapiens 35-38 15896459-1 2005 In this work, we described the proliferation of human non-small-cell-lung-cancer (NSCLC) cells H1437 harboring p53 alleles (proline-267) can be inhibited by low-dosage topoisomerase II inhibitor etoposide (VP-16) in vitro and in vivo. Proline 124-131 tumor protein p53 Homo sapiens 111-114 15899386-2 2005 TP53 has two common polymorphic forms encoding either proline or arginine, at position 72, and the presence of homozygous arginine has been reported as a risk factor for cervical cancer in many populations. Proline 54-61 tumor protein p53 Homo sapiens 0-4 16128105-6 2005 The p53 Pro/Pro genotype significantly increased the risk for developing keloid, compared to the combination of Pro/Arg and Arg/Arg genotypes,with the odds ratio (OR) of 2.400 (95%CI: 1.048-5.498). Proline 8-11 tumor protein p53 Homo sapiens 4-7 15814626-0 2005 The p53 codon 72 proline allele is associated with p53 gene mutations in non-small cell lung cancer. Proline 17-24 tumor protein p53 Homo sapiens 51-54 15633234-0 2005 Homozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellular carcinoma in Chinese population. Proline 17-20 tumor protein p53 Homo sapiens 24-27 15633234-10 2005 CONCLUSION: Homozygosity for Pro of p53 Arg72Pro is potentially one of the genetic risk factors for HCC in Chinese population. Proline 29-32 tumor protein p53 Homo sapiens 36-39 15732191-9 2005 Replacement of arginine (Arg) by proline (Pro) at position 72 of human p53 decreases its apoptotic potential [Dumont et al., 2003. Proline 33-40 tumor protein p53 Homo sapiens 71-74 16122882-1 2005 BACKGROUND: The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated in increasing susceptibility of the cervix to human papillomavirus (HPV) infection and thus altering cancer risk. Proline 44-47 tumor protein p53 Homo sapiens 78-81 16122882-1 2005 BACKGROUND: The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated in increasing susceptibility of the cervix to human papillomavirus (HPV) infection and thus altering cancer risk. Proline 51-54 tumor protein p53 Homo sapiens 78-81 16122882-1 2005 BACKGROUND: The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated in increasing susceptibility of the cervix to human papillomavirus (HPV) infection and thus altering cancer risk. Proline 51-54 tumor protein p53 Homo sapiens 78-81 15732191-9 2005 Replacement of arginine (Arg) by proline (Pro) at position 72 of human p53 decreases its apoptotic potential [Dumont et al., 2003. Proline 42-45 tumor protein p53 Homo sapiens 71-74 15844595-1 2005 OBJECTIVE: To investigate the codon-72 polymorphism of the tumor suppressor gene p53, codon-72 encodes arginine (Arg) or proline (Pro) for a genetic predisposition,to keloid or hypertrophic scar. Proline 121-128 tumor protein p53 Homo sapiens 81-84 15901131-5 2005 Intermediate expression of p53 was noted in cells with missense mutations or polymorphism to proline at codon 72 in exons 4-5, whereas there was slight or no visible expression in wild type cells and in cells with nonsense and frameshift mutations. Proline 93-100 tumor protein p53 Homo sapiens 27-30 15844595-1 2005 OBJECTIVE: To investigate the codon-72 polymorphism of the tumor suppressor gene p53, codon-72 encodes arginine (Arg) or proline (Pro) for a genetic predisposition,to keloid or hypertrophic scar. Proline 130-133 tumor protein p53 Homo sapiens 81-84 15371422-5 2004 The integrity of the DNA-binding core domain, the N-terminal transactivation domain, and the C-terminal oligomerization domains of p53 was essential for hTERT promoter repression, whereas the proline-rich domain and the extreme C terminus were not required. Proline 192-199 tumor protein p53 Homo sapiens 131-134 15355990-3 2004 Etk is physically associated with p53 through its Src homology 3 domain and the proline-rich domain of p53. Proline 80-87 tumor protein p53 Homo sapiens 34-37 15365822-2 2004 A recent report suggests that a polymorphism of the p53 tumor suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in the malignant transformation of colorectal adenoma to cancer. Proline 116-123 tumor protein p53 Homo sapiens 52-55 15365822-2 2004 A recent report suggests that a polymorphism of the p53 tumor suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in the malignant transformation of colorectal adenoma to cancer. Proline 116-123 tumor protein p53 Homo sapiens 179-182 15355990-3 2004 Etk is physically associated with p53 through its Src homology 3 domain and the proline-rich domain of p53. Proline 80-87 tumor protein p53 Homo sapiens 103-106 15262986-9 2004 Together, these findings suggest that p53 acts upstream of Bax to promote MDA-mediated cell death in a proline-rich domain-dependent manner through both transcription-dependent (by up-regulating PUMA expression) and -independent mechanisms in human colon cancer HCT116 cells. Proline 103-110 tumor protein p53 Homo sapiens 38-41 15533911-1 2004 A polymorphism at codon 72 of the human tumor suppressor p53 determines translation into either arginine or proline. Proline 108-115 tumor protein p53 Homo sapiens 57-60 15634502-13 2004 CONCLUSIONS: In northern Chinese women, p53 codon 72 Pro/Arg and p53 PIN3 gene polymorphisms are not associated with development of ovarian cancer. Proline 53-56 tumor protein p53 Homo sapiens 40-43 15672606-0 2004 A new set of monoclonal antibodies directed to proline-rich and central regions of p53. Proline 47-54 tumor protein p53 Homo sapiens 83-86 15672606-5 2004 The H53C2 and H53C3 MAbs are against different epitopes within the proline-rich region of p53. Proline 67-74 tumor protein p53 Homo sapiens 90-93 15240512-5 2004 The p53 codon 72 proline allele carriers were found to be more susceptible to progress to GC than to IM (OR = 2.22, 95%CI = 1.05-4.70, P = 0.038). Proline 17-24 tumor protein p53 Homo sapiens 4-7 15479836-7 2004 Analysis of c-Myc- and E2F1-mediated inhibition of a panel of Zta mutants shows parallel genetics and inhibition maps to a small bipartite sequence located between amino acids 29 and 53 of Zta, containing homology to the proline-rich domain of the tumor suppressor protein p53. Proline 221-228 tumor protein p53 Homo sapiens 273-276 15273281-3 2004 In this context, the proline form of TP53 codon 72 polymorphism has been recently associated with the risk of developing endometriosis. Proline 21-28 tumor protein p53 Homo sapiens 37-41 15131588-1 2004 A common arginine to proline polymorphism is harboured at codon 72 of the human p53 gene. Proline 21-28 tumor protein p53 Homo sapiens 80-83 15257943-1 2004 A single nucleotide polymorphism at TP53 codon 72 means that two alleles exist: A1 (proline residue, Pro72) and A2 (arginine residue, Arg72). Proline 84-91 tumor protein p53 Homo sapiens 36-40 15183530-0 2004 Proline homozygosity in codon 72 of p53 is a factor of susceptibility for thyroid cancer. Proline 0-7 tumor protein p53 Homo sapiens 36-39 15183530-1 2004 A common germline polymorphism of p53 gene produces an Arginine to Proline change at aminoacid position 72. Proline 67-74 tumor protein p53 Homo sapiens 34-37 15548361-0 2004 Selective loss of codon 72 proline p53 and frequent mutational inactivation of the retained arginine allele in colorectal cancer. Proline 27-34 tumor protein p53 Homo sapiens 35-38 15548361-1 2004 According to recent reports, some cancer types exhibit nonrandom allele loss at codon 72 in exon 4 of the p53 gene [coding for proline (72Pro) or arginine (72Arg)]. Proline 127-134 tumor protein p53 Homo sapiens 106-109 15069555-2 2004 The p53 codon 72 Arg right curved arrow Pro polymorphism has been suggested to be associated with risk for different kind of cancers, but the data on gastric cancer (GC) is very limited. Proline 40-43 tumor protein p53 Homo sapiens 4-7 15105048-3 2004 The p53 gene displays a common genetic Arg/Pro polymorphism at codon 72 with functional significance, that has been investigated as risk factor in several cancer models. Proline 43-46 tumor protein p53 Homo sapiens 4-7 15099969-2 2004 In this regard, genetic polymorphism at codon 72 (CCC/proline to CGC/arginine [Pro(72)Arg]) of the p53 gene is one of the most frequently studied subjects. Proline 54-61 tumor protein p53 Homo sapiens 99-102 15216398-9 2004 The frequency of pro/pro, pro/arg, and arg/arg in p53 codon 72 in cases was 15% (15/99), 58% (57/99), and 27% (27/99) and in controls was 17% (34/193), 48% (92/193), and 35% (67/193), respectively, which was not significantly different. Proline 17-20 tumor protein p53 Homo sapiens 50-53 15216398-9 2004 The frequency of pro/pro, pro/arg, and arg/arg in p53 codon 72 in cases was 15% (15/99), 58% (57/99), and 27% (27/99) and in controls was 17% (34/193), 48% (92/193), and 35% (67/193), respectively, which was not significantly different. Proline 21-24 tumor protein p53 Homo sapiens 50-53 15216398-9 2004 The frequency of pro/pro, pro/arg, and arg/arg in p53 codon 72 in cases was 15% (15/99), 58% (57/99), and 27% (27/99) and in controls was 17% (34/193), 48% (92/193), and 35% (67/193), respectively, which was not significantly different. Proline 21-24 tumor protein p53 Homo sapiens 50-53 15077186-1 2004 A single-nucleotide polymorphism (SNP) in exon 4 results in expression of either arginine (72R) or proline (72P) at codon 72 of p53. Proline 99-106 tumor protein p53 Homo sapiens 128-131 15041222-4 2004 The TP53 gene has a single polymorphism at codon 72 of exon 4 that encodes either arginine (Arg) or proline (Pro). Proline 100-107 tumor protein p53 Homo sapiens 4-8 15041222-4 2004 The TP53 gene has a single polymorphism at codon 72 of exon 4 that encodes either arginine (Arg) or proline (Pro). Proline 109-112 tumor protein p53 Homo sapiens 4-8 15263792-7 2004 The proline form of p53 gene codon 72 was significantly higher than the arginine form, with an odds ratio of 2.606 (95% CI = 1.052-6.455). Proline 4-11 tumor protein p53 Homo sapiens 20-23 14744727-1 2004 The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated as a risk marker in cervical neoplasia. Proline 32-35 tumor protein p53 Homo sapiens 66-69 14744727-1 2004 The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated as a risk marker in cervical neoplasia. Proline 39-42 tumor protein p53 Homo sapiens 66-69 14744727-1 2004 The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated as a risk marker in cervical neoplasia. Proline 39-42 tumor protein p53 Homo sapiens 66-69 15651660-2 2004 The functional oligonucleotide polymorphism of the p53 gene causes the substitution of arginine (Arg) for praline (Pro) in the codon 72. Proline 115-118 tumor protein p53 Homo sapiens 51-54 15263792-11 2004 The proline form of p53 gene codon 72 might be a more significant risk factor for the development of metastasis than the arginine form. Proline 4-11 tumor protein p53 Homo sapiens 20-23 14577584-0 2003 Polymorphism of the p53 codon 72 Arg/Pro and the risk of HPV type 16/18-associated cervical and oral cancer in India. Proline 37-40 tumor protein p53 Homo sapiens 20-23 14612423-0 2003 The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53. Proline 4-11 tumor protein p53 Homo sapiens 29-32 14612423-0 2003 The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53. Proline 4-11 tumor protein p53 Homo sapiens 145-148 14612423-5 2003 p300 binds in vitro to PXXP-containing peptides derived from the proline repeat domain, and PXXP-containing peptides inhibit sequence-specific DNA-dependent acetylation of p53, indicating that p300 docking to both the LXXLL and contiguous PXXP motif in p53 is required for p53 acetylation. Proline 65-72 tumor protein p53 Homo sapiens 172-175 14612423-5 2003 p300 binds in vitro to PXXP-containing peptides derived from the proline repeat domain, and PXXP-containing peptides inhibit sequence-specific DNA-dependent acetylation of p53, indicating that p300 docking to both the LXXLL and contiguous PXXP motif in p53 is required for p53 acetylation. Proline 65-72 tumor protein p53 Homo sapiens 253-256 14612423-5 2003 p300 binds in vitro to PXXP-containing peptides derived from the proline repeat domain, and PXXP-containing peptides inhibit sequence-specific DNA-dependent acetylation of p53, indicating that p300 docking to both the LXXLL and contiguous PXXP motif in p53 is required for p53 acetylation. Proline 65-72 tumor protein p53 Homo sapiens 253-256 14612423-6 2003 Deletion of the proline repeat motif of p53 prevents DNA-dependent acetylation of p53 by occluding p300 from the p53-DNA complex. Proline 16-23 tumor protein p53 Homo sapiens 40-43 14612423-6 2003 Deletion of the proline repeat motif of p53 prevents DNA-dependent acetylation of p53 by occluding p300 from the p53-DNA complex. Proline 16-23 tumor protein p53 Homo sapiens 82-85 14612423-6 2003 Deletion of the proline repeat motif of p53 prevents DNA-dependent acetylation of p53 by occluding p300 from the p53-DNA complex. Proline 16-23 tumor protein p53 Homo sapiens 82-85 14612423-7 2003 Sequence-specific DNA places an absolute requirement for the proline repeat domain to drive p53 acetylation in vivo. Proline 61-68 tumor protein p53 Homo sapiens 92-95 14612423-8 2003 Chromatin immunoprecipitation was used to show that the proline repeat deletion mutant p53 is bound to the p21 promoter in vivo, but it is not acetylated, indicating that proline-directed acetylation of p53 is a post-DNA binding event. Proline 56-63 tumor protein p53 Homo sapiens 87-90 14612423-8 2003 Chromatin immunoprecipitation was used to show that the proline repeat deletion mutant p53 is bound to the p21 promoter in vivo, but it is not acetylated, indicating that proline-directed acetylation of p53 is a post-DNA binding event. Proline 56-63 tumor protein p53 Homo sapiens 203-206 14612423-8 2003 Chromatin immunoprecipitation was used to show that the proline repeat deletion mutant p53 is bound to the p21 promoter in vivo, but it is not acetylated, indicating that proline-directed acetylation of p53 is a post-DNA binding event. Proline 171-178 tumor protein p53 Homo sapiens 87-90 14612423-8 2003 Chromatin immunoprecipitation was used to show that the proline repeat deletion mutant p53 is bound to the p21 promoter in vivo, but it is not acetylated, indicating that proline-directed acetylation of p53 is a post-DNA binding event. Proline 171-178 tumor protein p53 Homo sapiens 203-206 14612423-9 2003 The PXXP repeat expands the basic interface of a p300-targeted transactivation domain, and proline-directed acetylation of p53 at promoters indicates that p300-mediated acetylation can be highly constrained by substrate conformation in vivo. Proline 91-98 tumor protein p53 Homo sapiens 123-126 14581358-0 2003 Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patients. Proline 126-133 tumor protein p53 Homo sapiens 17-20 14581358-5 2003 RESULTS: We found that the retention of the p53 codon 72 arginine allele in the tumor tissue of proline/arginine heterozygous breast cancer patients is associated with statistically significant reduced disease-free and overall survivals. Proline 96-103 tumor protein p53 Homo sapiens 44-47 14581358-6 2003 CONCLUSIONS: Our findings suggest that the genotyping for p53 codon 72 locus in both the tumor tissue and in the lymph node of breast cancer patients could contribute to identify a subset of arginine/proline heterozygous patients who have a reduced survival that is associated with the specific retention of the arginine allele in the tumor tissue. Proline 200-207 tumor protein p53 Homo sapiens 58-61 14577584-3 2003 This degradation is controlled by a common polymorphism of the p53 gene encoding either a proline or an arginine at its codon 72 in exon 4. Proline 90-97 tumor protein p53 Homo sapiens 63-66 14577584-4 2003 Recently, it has been demonstrated that the presence of homozygous arginine at codon 72 renders p53 about seven times more susceptible to E6-mediated proteolytic degradation as well as to cervical cancer than those with proline homozygotes or proline/arginine heterozygotes. Proline 243-250 tumor protein p53 Homo sapiens 96-99 12743601-6 2003 Tumor-associated p53 mutants however are attenuated for YB1 nuclear localization as are mutants mutated in the proline-rich domain of p53. Proline 111-118 tumor protein p53 Homo sapiens 17-20 12893432-2 2003 To address on the genetic risk factor for NPC, we investigated association between the p53 codon 72 polymorphism (Pro/Arg) and NPC susceptibility in the Thai. Proline 114-117 tumor protein p53 Homo sapiens 87-90 12881708-1 2003 The N-terminal proline-rich domain of human p53 has been shown to be important for the induction of apoptosis. Proline 15-22 tumor protein p53 Homo sapiens 44-47 12853970-3 2003 Previously, we and others have shown that some functional domains in p53, such as the DNA-binding and tetramerization domains, are required for inducing both cell cycle arrest and apoptosis whereas others, such as the second activation domain, the proline-rich domain, and the C-terminal basic domain, are only required for inducing apoptosis. Proline 248-255 tumor protein p53 Homo sapiens 69-72 12609999-0 2003 The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein. Proline 28-35 tumor protein p53 Homo sapiens 84-87 12609999-1 2003 The p53 transcription factor contains two separate tandem activation domains (AD1 and AD2), a proline-rich domain (PRD), and a C-terminal basic domain (BD). Proline 94-101 tumor protein p53 Homo sapiens 4-7 12919725-1 2003 The p53 gene has a polymorphism at codon 72 that presents the arginine or proline genotype, although this polymorphism has been associated with genetically determined susceptibility to lung cancers, the literature has not been consistent with this association. Proline 74-81 tumor protein p53 Homo sapiens 4-7 12796380-8 2003 After adjustment for age and gender, a logistic regression analysis suggested that the risk for a p53 Arg homozygous patient to develop cardia cancer is 3.1 95% confidence interval, 1.4-7.3) times greater than for p53 Pro homozygous and p53 Arg/Pro heterozygous patients. Proline 218-221 tumor protein p53 Homo sapiens 98-101 12796380-8 2003 After adjustment for age and gender, a logistic regression analysis suggested that the risk for a p53 Arg homozygous patient to develop cardia cancer is 3.1 95% confidence interval, 1.4-7.3) times greater than for p53 Pro homozygous and p53 Arg/Pro heterozygous patients. Proline 218-221 tumor protein p53 Homo sapiens 214-217 12796380-8 2003 After adjustment for age and gender, a logistic regression analysis suggested that the risk for a p53 Arg homozygous patient to develop cardia cancer is 3.1 95% confidence interval, 1.4-7.3) times greater than for p53 Pro homozygous and p53 Arg/Pro heterozygous patients. Proline 218-221 tumor protein p53 Homo sapiens 214-217 12743601-6 2003 Tumor-associated p53 mutants however are attenuated for YB1 nuclear localization as are mutants mutated in the proline-rich domain of p53. Proline 111-118 tumor protein p53 Homo sapiens 134-137 14513722-2 2003 (1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform. Proline 22-29 tumor protein p53 Homo sapiens 95-98 12684648-2 2003 A sequence polymorphism at codon 72 of the p53 gene results in either a proline or an arginine and may induce different functional activities. Proline 72-79 tumor protein p53 Homo sapiens 43-46 12628849-2 2003 A common polymorphism at codon 72 of exon 4 encoding either arginine (Arg) or proline (Pro) has been shown to affect HPV-mediated degradation of p53 in vitro, and may represent a risk factor for HPV-induced carcinogenesis. Proline 78-85 tumor protein p53 Homo sapiens 145-148 12628849-2 2003 A common polymorphism at codon 72 of exon 4 encoding either arginine (Arg) or proline (Pro) has been shown to affect HPV-mediated degradation of p53 in vitro, and may represent a risk factor for HPV-induced carcinogenesis. Proline 87-90 tumor protein p53 Homo sapiens 145-148 12567188-1 2003 The gene TP53, encoding p53, has a common sequence polymorphism that results in either proline or arginine at amino-acid position 72. Proline 87-94 tumor protein p53 Homo sapiens 9-13 12567188-1 2003 The gene TP53, encoding p53, has a common sequence polymorphism that results in either proline or arginine at amino-acid position 72. Proline 87-94 tumor protein p53 Homo sapiens 24-27 12567188-2 2003 This polymorphism occurs in the proline-rich domain of p53, which is necessary for the protein to fully induce apoptosis. Proline 32-39 tumor protein p53 Homo sapiens 55-58 12648751-2 2003 We performed a case-control association study between sporadic AD and the common proline/arginine polymorphism at codon 72 in the pro-apoptotic gene p53, in 109 sporadic AD patients and in 111 controls. Proline 81-88 tumor protein p53 Homo sapiens 149-152 12726864-3 2003 A polymorphism encoding either arginine (72R) or proline (72P) at codon 72 of p53 influences inhibition of p73 by a range of p53 mutants identified in squamous cancers. Proline 49-56 tumor protein p53 Homo sapiens 78-81 12726864-3 2003 A polymorphism encoding either arginine (72R) or proline (72P) at codon 72 of p53 influences inhibition of p73 by a range of p53 mutants identified in squamous cancers. Proline 49-56 tumor protein p53 Homo sapiens 125-128 14513722-2 2003 (1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform. Proline 22-29 tumor protein p53 Homo sapiens 172-175 14513722-2 2003 (1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform. Proline 22-29 tumor protein p53 Homo sapiens 172-175 14513722-2 2003 (1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform. Proline 299-306 tumor protein p53 Homo sapiens 95-98 14513722-2 2003 (1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform. Proline 299-306 tumor protein p53 Homo sapiens 172-175 14513722-2 2003 (1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform. Proline 299-306 tumor protein p53 Homo sapiens 172-175 12635827-4 2003 The genotype of p53 codon 72 (Arg/Arg, Arg/Pro, or Pro/Pro) was determined for all subjects by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). Proline 43-46 tumor protein p53 Homo sapiens 16-19 12708345-1 2003 In codon 72 of the p53 antioncogene there are two alleles, arginine and proline; the arg/arg genotype has recently been identified as a risk factor for developing of cervicouterine cancer (CuCa) associated to human papillomavirus (HVP) infection. Proline 72-79 tumor protein p53 Homo sapiens 19-22 12708345-5 2003 From 102 analyzed samples, p53-arginine allele corresponded to 67.64% and p53-proline allele corresponded to 32.36%; 47 women (46.10%) were arg/arg homocygotes, 11 women (10.77%) were pro/pro homocygotes, 44 women (43.13%) were arg/pro heterocigotes; the genotype distribution was within the Hardy-Weinberg equilibrium. Proline 78-85 tumor protein p53 Homo sapiens 74-77 12530090-2 2002 The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid codon 72 of the p53 protein. Proline 114-121 tumor protein p53 Homo sapiens 32-36 12388558-2 2002 The increase in p53 stability depends critically on its phosphorylation on serine/threonine residues, including those preceding a proline (Ser(P)/Thr-Pro). Proline 130-137 tumor protein p53 Homo sapiens 16-19 12406566-0 2002 Proline homozygosity in codon 72 of p53: a risk genotype for human papillomavirus related cervical cancer in Indian women. Proline 0-7 tumor protein p53 Homo sapiens 36-39 12406566-7 2002 Thus, proline homozygosity at codon 72 of p53 and not arginine homozygosity, could be a risk factor for development of CaCx associated with high risk HPV among Indian women. Proline 6-13 tumor protein p53 Homo sapiens 42-45 12459171-2 2002 In this report, we addressed the question whether the natural variability at p53 locus (the proline-arginine substitution at codon 72) affects the capacity of peripheral-blood mononuclear cells from healthy subjects to undergo in vitro apoptosis in response to the cytotoxic drug cytosine arabinoside. Proline 92-99 tumor protein p53 Homo sapiens 77-80 12496062-1 2002 An Arg/Pro polymorphism in codon 72 of the TP53 gene was analyzed in blood samples from 390 breast and 162 colorectal cancer patients previously investigated for TP53 mutations in their tumors. Proline 7-10 tumor protein p53 Homo sapiens 43-47 12530090-2 2002 The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid codon 72 of the p53 protein. Proline 114-121 tumor protein p53 Homo sapiens 158-161 12530090-2 2002 The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid codon 72 of the p53 protein. Proline 123-126 tumor protein p53 Homo sapiens 32-36 12530090-2 2002 The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid codon 72 of the p53 protein. Proline 123-126 tumor protein p53 Homo sapiens 158-161 12397361-3 2002 Here we report that DNA damage specifically induces p53 phosphorylation on Ser/Thr-Pro motifs, which facilitates its interaction with Pin1, a member of peptidyl-prolyl isomerase. Proline 83-86 tumor protein p53 Homo sapiens 52-55 12370767-0 2002 Homozygous proline at codon 72 of p53 as a potential risk factor favoring the development of undifferentiated thyroid carcinoma. Proline 11-18 tumor protein p53 Homo sapiens 34-37 12370767-13 2002 We conclude that homozygous proline is a potential risk factor favoring the development of an undifferentiated thyroid carcinoma, and that the homozygous phenotypes at codon 72 of p53 are associated with a poorer prognosis of thyroid carcinoma. Proline 28-35 tumor protein p53 Homo sapiens 180-183 12368717-4 2002 The proline residue at codon 72 of the p53 gene was significantly over represented in the POAG patients relative to healthy controls. Proline 4-11 tumor protein p53 Homo sapiens 39-42 12368717-12 2002 CONCLUSIONS: Association between the p53 gene encoding for proline at codon 72 and POAG presumably exists in some ethnic populations but cannot be used as a predictor for the role of the gene as a common regulator of cell death of retinal ganglions leading to POAG. Proline 59-66 tumor protein p53 Homo sapiens 37-40 12084746-8 2002 RESULTS: There were significant differences in the distribution of the polymorphism between the control subjects and the POAG patients (p = 0.00782) The proline form of p53 gene codon 72 appears to be a significant risk factor in the development of POAG (odds ratio 2.389, 95% confidence interval: 1.14 to 5.01). Proline 153-160 tumor protein p53 Homo sapiens 169-172 12065086-3 2002 The p53 codon 72 Arg/Pro polymorphism has been suggested to be associated with susceptibility to tobacco-related cancers, but this association remains controversial. Proline 21-24 tumor protein p53 Homo sapiens 4-7 12144822-7 2002 The frequency of distribution of the three genotypes of p53 codon 72 in a subgroup of the HPV16/18-positive cervical cancer patients was Pro/Pro 0.18 and Arg/Arg 0.26, with the heterozygous Pro/Arg 0.56, differing significantly from the genotype frequency in the normal healthy women (chi(2) = 6.928, df = 2, P < 0.05). Proline 141-144 tumor protein p53 Homo sapiens 56-59 12144822-2 2002 A common polymorphism of p53 in exon 4 codon 72, resulting in either proline (Pro) or arginine (Arg), affects HPV16/18 E6-mediated degradation of p53 protein in vivo. Proline 69-76 tumor protein p53 Homo sapiens 25-28 12144822-2 2002 A common polymorphism of p53 in exon 4 codon 72, resulting in either proline (Pro) or arginine (Arg), affects HPV16/18 E6-mediated degradation of p53 protein in vivo. Proline 69-76 tumor protein p53 Homo sapiens 146-149 12144822-2 2002 A common polymorphism of p53 in exon 4 codon 72, resulting in either proline (Pro) or arginine (Arg), affects HPV16/18 E6-mediated degradation of p53 protein in vivo. Proline 78-81 tumor protein p53 Homo sapiens 25-28 12144822-2 2002 A common polymorphism of p53 in exon 4 codon 72, resulting in either proline (Pro) or arginine (Arg), affects HPV16/18 E6-mediated degradation of p53 protein in vivo. Proline 78-81 tumor protein p53 Homo sapiens 146-149 12144822-7 2002 The frequency of distribution of the three genotypes of p53 codon 72 in a subgroup of the HPV16/18-positive cervical cancer patients was Pro/Pro 0.18 and Arg/Arg 0.26, with the heterozygous Pro/Arg 0.56, differing significantly from the genotype frequency in the normal healthy women (chi(2) = 6.928, df = 2, P < 0.05). Proline 137-140 tumor protein p53 Homo sapiens 56-59 12144822-7 2002 The frequency of distribution of the three genotypes of p53 codon 72 in a subgroup of the HPV16/18-positive cervical cancer patients was Pro/Pro 0.18 and Arg/Arg 0.26, with the heterozygous Pro/Arg 0.56, differing significantly from the genotype frequency in the normal healthy women (chi(2) = 6.928, df = 2, P < 0.05). Proline 141-144 tumor protein p53 Homo sapiens 56-59 12115545-1 2002 p53 codon 72, which produces variant proteins with an arginine (Arg) or proline (Pro), has been reported to be associated with cancers of the lung, esophagus and cervix. Proline 72-79 tumor protein p53 Homo sapiens 0-3 12115545-1 2002 p53 codon 72, which produces variant proteins with an arginine (Arg) or proline (Pro), has been reported to be associated with cancers of the lung, esophagus and cervix. Proline 81-84 tumor protein p53 Homo sapiens 0-3 12164929-1 2002 Upregulation of p53 protein induces either growth arrest or apoptosis in response to cellular injury This is signaled from a highly conserved p53 domain between codons 64 and 92, where a functional polymorphism results in either a proline (p53-72P) or an arginine (p53-72R) at codon 72. Proline 231-238 tumor protein p53 Homo sapiens 16-19 12221910-1 2002 A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC. Proline 197-200 tumor protein p53 Homo sapiens 34-37 12221910-1 2002 A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC. Proline 197-200 tumor protein p53 Homo sapiens 177-180 12221910-1 2002 A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC. Proline 197-200 tumor protein p53 Homo sapiens 177-180 12221910-1 2002 A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC. Proline 197-200 tumor protein p53 Homo sapiens 177-180 12221910-6 2002 Among cases with CC the proportions of the p53 genotypes at codon 72 were 0.05 to proline homozygous, 0.5 to heterozygous, and 0.45 to arginine-homozygous. Proline 82-89 tumor protein p53 Homo sapiens 43-46 12164929-1 2002 Upregulation of p53 protein induces either growth arrest or apoptosis in response to cellular injury This is signaled from a highly conserved p53 domain between codons 64 and 92, where a functional polymorphism results in either a proline (p53-72P) or an arginine (p53-72R) at codon 72. Proline 231-238 tumor protein p53 Homo sapiens 142-145 12164929-1 2002 Upregulation of p53 protein induces either growth arrest or apoptosis in response to cellular injury This is signaled from a highly conserved p53 domain between codons 64 and 92, where a functional polymorphism results in either a proline (p53-72P) or an arginine (p53-72R) at codon 72. Proline 231-238 tumor protein p53 Homo sapiens 142-145 12164929-1 2002 Upregulation of p53 protein induces either growth arrest or apoptosis in response to cellular injury This is signaled from a highly conserved p53 domain between codons 64 and 92, where a functional polymorphism results in either a proline (p53-72P) or an arginine (p53-72R) at codon 72. Proline 231-238 tumor protein p53 Homo sapiens 142-145 12168882-5 2002 The amino acid residue at this position is either arginine (p53-Arg) or proline (p53-Pro). Proline 72-79 tumor protein p53 Homo sapiens 81-84 11571642-0 2001 p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress. Proline 67-74 tumor protein p53 Homo sapiens 0-3 12006537-1 2002 PURPOSE: It is known that a common p53 polymorphism, encodingeither proline (Pro) or arginine (Arg) at residue 72, produces marked change in the structure of p53. Proline 68-75 tumor protein p53 Homo sapiens 35-38 12006537-1 2002 PURPOSE: It is known that a common p53 polymorphism, encodingeither proline (Pro) or arginine (Arg) at residue 72, produces marked change in the structure of p53. Proline 68-75 tumor protein p53 Homo sapiens 158-161 12006537-1 2002 PURPOSE: It is known that a common p53 polymorphism, encodingeither proline (Pro) or arginine (Arg) at residue 72, produces marked change in the structure of p53. Proline 77-80 tumor protein p53 Homo sapiens 35-38 12006537-1 2002 PURPOSE: It is known that a common p53 polymorphism, encodingeither proline (Pro) or arginine (Arg) at residue 72, produces marked change in the structure of p53. Proline 77-80 tumor protein p53 Homo sapiens 158-161 12006537-7 2002 RESULTS: There was a bias to mutate and express the Arg allele in the p53 -mutated TCCs arising in individuals with heterozygosity (Pro/Arg). Proline 132-135 tumor protein p53 Homo sapiens 70-73 12575207-1 2002 OBJECTIVE: A polymorphism at codon 72 of the human tumor-suppressor gene, p53, results in translation to either arginine or proline. Proline 124-131 tumor protein p53 Homo sapiens 74-77 11564578-1 2001 The p53 codon 72 polymorphism, resulting in either an arginine or a proline residue has been proposed to affect the susceptibility of p53 protein to human papilloma virus (HPV) E6-mediated degradation in vitro. Proline 68-75 tumor protein p53 Homo sapiens 4-7 11564578-1 2001 The p53 codon 72 polymorphism, resulting in either an arginine or a proline residue has been proposed to affect the susceptibility of p53 protein to human papilloma virus (HPV) E6-mediated degradation in vitro. Proline 68-75 tumor protein p53 Homo sapiens 134-137 11807792-3 2002 A common polymorphism of p53, encoding either proline (Pro) or arginine (Arg) at position 72, affects the susceptibility of p53 to E6 mediated degradation in vivo. Proline 46-53 tumor protein p53 Homo sapiens 25-28 11807792-3 2002 A common polymorphism of p53, encoding either proline (Pro) or arginine (Arg) at position 72, affects the susceptibility of p53 to E6 mediated degradation in vivo. Proline 46-53 tumor protein p53 Homo sapiens 124-127 11807792-3 2002 A common polymorphism of p53, encoding either proline (Pro) or arginine (Arg) at position 72, affects the susceptibility of p53 to E6 mediated degradation in vivo. Proline 55-58 tumor protein p53 Homo sapiens 25-28 11807792-3 2002 A common polymorphism of p53, encoding either proline (Pro) or arginine (Arg) at position 72, affects the susceptibility of p53 to E6 mediated degradation in vivo. Proline 55-58 tumor protein p53 Homo sapiens 124-127 11791172-0 2002 The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells. Proline 4-11 tumor protein p53 Homo sapiens 27-30 11779589-0 2002 The proline form of p53 codon 72 polymorphism is associated with endometriosis. Proline 4-11 tumor protein p53 Homo sapiens 20-23 14577491-10 2002 P53 mutation was confirmed only in 1 patient with pTaG2 tumor in exon 5 (deletion of proline 128). Proline 85-92 tumor protein p53 Homo sapiens 0-3 11802048-0 2002 Prognostic significance of the proline form of p53 codon 72 polymorphism in nasopharyngeal carcinoma. Proline 31-38 tumor protein p53 Homo sapiens 47-50 11571642-0 2001 p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress. Proline 67-74 tumor protein p53 Homo sapiens 90-93 11571642-7 2001 However, the proline-rich domain towards the N-terminus of p53 (residues 67 to 98) appeared important for binding to the nuclear matrix. Proline 13-20 tumor protein p53 Homo sapiens 59-62 11571642-9 2001 The proline-rich domain of p53 has potential for SH3 protein-protein interaction, and has a role in p53-mediated apoptosis and possibly base excision repair of DNA damage. Proline 4-11 tumor protein p53 Homo sapiens 27-30 11571642-9 2001 The proline-rich domain of p53 has potential for SH3 protein-protein interaction, and has a role in p53-mediated apoptosis and possibly base excision repair of DNA damage. Proline 4-11 tumor protein p53 Homo sapiens 100-103 11280728-0 2001 Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species. Proline 76-83 tumor protein p53 Homo sapiens 28-31 11429426-2 2001 A recent report suggests that a polymorphism of the p53 tumour suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in HPV associated malignancies. Proline 117-124 tumor protein p53 Homo sapiens 52-55 11429426-2 2001 A recent report suggests that a polymorphism of the p53 tumour suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in HPV associated malignancies. Proline 117-124 tumor protein p53 Homo sapiens 180-183 11429426-7 2001 RESULTS: The proportions of p53 codon 72 genotypes found were 78% arginine homozygous, 2% proline homozygous, and 20% heterozygous among patients with skin cancer and 79% arginine homozygous, 3.5% proline homozygous, and 17.5% heterozygous among the control population. Proline 90-97 tumor protein p53 Homo sapiens 28-31 11429426-7 2001 RESULTS: The proportions of p53 codon 72 genotypes found were 78% arginine homozygous, 2% proline homozygous, and 20% heterozygous among patients with skin cancer and 79% arginine homozygous, 3.5% proline homozygous, and 17.5% heterozygous among the control population. Proline 197-204 tumor protein p53 Homo sapiens 28-31 11359905-0 2001 The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation. Proline 42-49 tumor protein p53 Homo sapiens 65-68 11359905-4 2001 Stabilization of p53 by Sin3 requires the Sin3-binding domain, determined here to map to the proline-rich region of p53, from amino acids 61 to 75. Proline 93-100 tumor protein p53 Homo sapiens 17-20 11359905-4 2001 Stabilization of p53 by Sin3 requires the Sin3-binding domain, determined here to map to the proline-rich region of p53, from amino acids 61 to 75. Proline 93-100 tumor protein p53 Homo sapiens 116-119 11280728-9 2001 We hypothesize that proline oxidation supports the generation of ROS by donating reducing potential to an electron transport chain altered either by p53-dependent mechanisms or by overexpression of POX. Proline 20-27 tumor protein p53 Homo sapiens 149-152 11280728-1 2001 The p53-dependent initiation of apoptosis is accompanied by the induction of proline oxidase (POX), a mitochondrial enzyme catalyzing the conversion of proline to pyrroline-5-carboxylate with the concomitant transfer of electrons to cytochrome c. Proline 77-84 tumor protein p53 Homo sapiens 4-7 11314008-3 2001 Core sequence of the predicted clam p53 (Map53) and p73 (Map73) proteins is virtually identical and includes the following highly conserved regions: the transcriptional activation domain (TAD), MDM2 binding site, ATM phosphorylation site, proline rich domain, DNA binding domains (DBDs) II-V, nuclear import and export signals and the tetramerization domain. Proline 239-246 tumor protein p53 Homo sapiens 36-39 11669337-10 2001 A common polymorphism in p53 at codon 72 (arginine/proline) was found in 6/8 of the patients. Proline 51-58 tumor protein p53 Homo sapiens 25-28 11174479-1 2001 OBJECTIVE: It has recently been suggested that white women who are homozygous for the allele of the gene for wild-type p53 protein (TP53) that encodes arginine at position 72 are more susceptible to human papillomavirus-associated cervical carcinoma than are women who are heterozygous for this polymorphism and women who are homozygous for the allele that encodes proline at that position. Proline 365-372 tumor protein p53 Homo sapiens 119-122 11174479-1 2001 OBJECTIVE: It has recently been suggested that white women who are homozygous for the allele of the gene for wild-type p53 protein (TP53) that encodes arginine at position 72 are more susceptible to human papillomavirus-associated cervical carcinoma than are women who are heterozygous for this polymorphism and women who are homozygous for the allele that encodes proline at that position. Proline 365-372 tumor protein p53 Homo sapiens 132-136 11069295-6 2000 Proline oxidase, a mitochondrial enzyme involved in the proline/pyrroline-5-carboxylate redox cycle, was up-regulated by p53 in ECV but not in DECV cells. Proline 56-63 tumor protein p53 Homo sapiens 121-124 11069295-9 2000 The results directly implicate proline oxidase and the proline/P5C pathway in p53-induced growth suppression and apoptosis. Proline 31-38 tumor protein p53 Homo sapiens 78-81 11072671-2 2000 In invasive cervical cancer, the arginine form of the p53 gene is estimated to be more susceptible to degradation mediated by tumour-associated human papilloma viruses (HPV) than the proline form. Proline 183-190 tumor protein p53 Homo sapiens 54-57 11045785-13 2000 In conclusion, the codon 72 germ-line polymorphism (Arg/Pro) of the common tumor suppressor gene p53 contributes to heritable susceptibility for smoke-induced lung adenocarcinoma. Proline 56-59 tumor protein p53 Homo sapiens 97-100 11127705-0 2000 Distributions of p53 codon 72 polymorphism in bladder cancer--proline form is prominent in invasive tumor. Proline 62-69 tumor protein p53 Homo sapiens 17-20 11240705-1 2000 Recent analysis of the codon-72 polymorphism of the p53 gene, the allele encoding proline or arginine, suggested that the homozygous Arg/Arg genotype is a significant risk factor for cervical cancer associated with human papillomavirus (HPV). Proline 82-89 tumor protein p53 Homo sapiens 52-55 11008209-10 2000 This result remained similar (OR 2.2, 95% CI 1.0-4.8 for p53 Pro/Pro vs. Arg/Arg), even after further adjustment for NAT2 and GSTP1 polymorphisms. Proline 61-64 tumor protein p53 Homo sapiens 57-60 11008209-10 2000 This result remained similar (OR 2.2, 95% CI 1.0-4.8 for p53 Pro/Pro vs. Arg/Arg), even after further adjustment for NAT2 and GSTP1 polymorphisms. Proline 65-68 tumor protein p53 Homo sapiens 57-60 10777217-0 2000 Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain. Proline 110-117 tumor protein p53 Homo sapiens 57-60 10850407-2 2000 The arginine allele at codon 72 of p53 was found to be more susceptible to degradation by HPV E6 protein than is the proline allele in vivo, thus resulting in a high frequency of cervical SCC in individuals homozygous for arginine at the codon. Proline 117-124 tumor protein p53 Homo sapiens 35-38 10719058-4 2000 It was revealed that the arginine form of p53 is more susceptible to degradation by the HPV E6 protein than the proline form and that patients with the arginine form have a higher risk of developing cancer than those with the proline form. Proline 112-119 tumor protein p53 Homo sapiens 42-45 10719058-4 2000 It was revealed that the arginine form of p53 is more susceptible to degradation by the HPV E6 protein than the proline form and that patients with the arginine form have a higher risk of developing cancer than those with the proline form. Proline 226-233 tumor protein p53 Homo sapiens 42-45 10777217-2 2000 A p53 protein lacking the proline-rich region (p53delta62-91) induces many p53-responsive genes but not PIG3. Proline 26-33 tumor protein p53 Homo sapiens 2-5 10777217-2 2000 A p53 protein lacking the proline-rich region (p53delta62-91) induces many p53-responsive genes but not PIG3. Proline 26-33 tumor protein p53 Homo sapiens 47-50 10777217-4 2000 We show here that the replacement of the N-terminal (amino acids 1-80) or C-terminal (amino acids 344-393) domains of p53 with heterologous domains does not interfere with transcription from the PIG3 promoter, but these chimeras still require the proline-rich region for PIG3 activation. Proline 247-254 tumor protein p53 Homo sapiens 118-121 10813720-3 2000 RESULTS: Among these polymorphisms, the individuals carrying arginine/proline genotypes of p53 showed a 9.5-fold increase of cervical carcinoma risk (95% confidence interval [CI], 4.9-18.6) compared with those individuals carrying arginine/arginine genotypes. Proline 70-77 tumor protein p53 Homo sapiens 91-94 10813720-6 2000 The individuals carrying both the arginine/proline genotype of p53 and the null genotype of GSTT1 showed a 3.5-fold increase of cervical carcinoma risk (95% CI, 1.8-7.1) compared with those individuals carrying both the arginine/arginine genotype of p53 and the GSTT1 positive genotype. Proline 43-50 tumor protein p53 Homo sapiens 63-66 10813720-9 2000 CONCLUSIONS: The results of the current study suggested that the arginine/proline genotype of p53, independently or in conjunction with the GSTT1 null genotype, could affect the genetic susceptibility for cervical carcinoma, and HPV positive women carrying both null genotypes of GSTT1 and GSTM1 have an increased risk of cervical carcinoma developing before age 40 years. Proline 74-81 tumor protein p53 Homo sapiens 94-97 10775606-8 2000 The deletion analysis of the p53 protein shows that the RPA binding, proline-rich regulatory, DNA-binding, and oligomerization domains are necessary for p53 action in both replication systems. Proline 69-76 tumor protein p53 Homo sapiens 29-32 10775606-8 2000 The deletion analysis of the p53 protein shows that the RPA binding, proline-rich regulatory, DNA-binding, and oligomerization domains are necessary for p53 action in both replication systems. Proline 69-76 tumor protein p53 Homo sapiens 153-156 10802655-3 2000 The binding of such mutants is influenced by whether TP53 (encoding p53) codon 72, by virtue of a common polymorphism in the human population, encodes Arg or Pro. Proline 158-161 tumor protein p53 Homo sapiens 53-57 10802655-3 2000 The binding of such mutants is influenced by whether TP53 (encoding p53) codon 72, by virtue of a common polymorphism in the human population, encodes Arg or Pro. Proline 158-161 tumor protein p53 Homo sapiens 68-71 10794489-1 2000 A case-control study was performed to investigate the risk of cervical cancer associated with p53 polymorphism at codon 72, encoding either arginine or proline. Proline 152-159 tumor protein p53 Homo sapiens 94-97 10777217-10 2000 Our results suggest that the proline-rich domain of p53 affects the ability of the central domain to bind DNA. Proline 29-36 tumor protein p53 Homo sapiens 52-55 10777217-11 2000 Moreover, some tumor-derived mutations within the central DNA binding domain of p53 mimic the loss of the proline-rich domain. Proline 106-113 tumor protein p53 Homo sapiens 80-83 10660538-4 2000 Contrary to bax, another known pro-apoptotic p53-target gene, both mouse and human FAS p53REs are still activated by the discriminatory p53 mutants Pro-175 and Ala-143, a class of mutants unable to induce apoptosis. Proline 148-151 tumor protein p53 Homo sapiens 87-90 10660538-4 2000 Contrary to bax, another known pro-apoptotic p53-target gene, both mouse and human FAS p53REs are still activated by the discriminatory p53 mutants Pro-175 and Ala-143, a class of mutants unable to induce apoptosis. Proline 148-151 tumor protein p53 Homo sapiens 87-90 10719811-1 2000 A common polymorphism of the wild type p53 is known at codon 72 of exon 4, with 2 alleles encoding either arginine (CGC, p53Arg) or proline (CCC, p53Pro). Proline 132-139 tumor protein p53 Homo sapiens 39-42 10680816-2 2000 Sequencing of the p53 gene, exon 4, showed heterozygosity (Arg-Pro) at codon 72 in five of six PML patients. Proline 63-66 tumor protein p53 Homo sapiens 18-21 11996107-1 2000 A polymorphism at codon 72 of gene p53 results in the presence of either arginine or proline at this position. Proline 85-92 tumor protein p53 Homo sapiens 35-38 10574967-7 1999 Docking of the computed low energy conformations for the C-terminal peptide with those for a recently defined proline-rich regulatory region from the N-terminal domain of p53 suggests a unique low energy complex between the two peptide domains. Proline 110-117 tumor protein p53 Homo sapiens 171-174 10602521-6 1999 In contrast, human p53 is not a substrate for recombinant MAP kinase nor are there any detectable levels of protein kinase activity in stimulated human cell extracts which phosphorylate the proline rich domain of human p53 in vitro. Proline 190-197 tumor protein p53 Homo sapiens 219-222 10449610-1 1999 A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. Proline 81-88 tumor protein p53 Homo sapiens 34-37 10647890-2 1999 A common p53 polymorphism at codon-72 of exon 4 results in translation to either arginine or proline. Proline 93-100 tumor protein p53 Homo sapiens 9-12 10449610-1 1999 A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. Proline 81-88 tumor protein p53 Homo sapiens 163-166 9707426-0 1998 The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression. Proline 28-35 tumor protein p53 Homo sapiens 24-27 10469618-5 1999 It has recently been reported that the extent of p53 dysfunction caused by HPVs depends on the status of a polymorphism at codon 72 of p53, Pro or Arg. Proline 140-143 tumor protein p53 Homo sapiens 49-52 10321740-2 1999 Several functional domains necessary for mediating cell cycle arrest and apoptosis in p53 have been mapped, e.g., the proline-rich domain. Proline 118-125 tumor protein p53 Homo sapiens 86-89 10321740-5 1999 We found that p53(delta62-91), which lacks all five PXXP motifs in human p53, is capable of inducing cell cycle arrest but not apoptosis, while p53(gln22-ser23/delta62-91), which contains a double point mutation in the activation domain as well as deletion of the proline-rich domain, completely loses its activity. Proline 264-271 tumor protein p53 Homo sapiens 14-17 10321740-10 1999 These results suggest that the proline-rich region may play a role in chromatin remodeling, which counteracts chromatin-mediated repression for some of the endogenous p53 target genes. Proline 31-38 tumor protein p53 Homo sapiens 167-170 9788606-2 1998 A common polymorphism of p53, encoding either proline or arginine at position 72, affects the susceptibility of p53 to E6-mediated degradation in vivo; Caucasian women homozygous for arginine 72 reportedly are about seven times more susceptible to HPV-associated carcinoma of the cervix than heterozygotes. Proline 46-53 tumor protein p53 Homo sapiens 25-28 9788606-2 1998 A common polymorphism of p53, encoding either proline or arginine at position 72, affects the susceptibility of p53 to E6-mediated degradation in vivo; Caucasian women homozygous for arginine 72 reportedly are about seven times more susceptible to HPV-associated carcinoma of the cervix than heterozygotes. Proline 46-53 tumor protein p53 Homo sapiens 112-115 9742979-1 1998 BACKGROUND: A polymorphism at codon 72 of the human tumour-suppressor gene, p53, results in translation to either arginine or proline. Proline 126-133 tumor protein p53 Homo sapiens 76-79 9707426-6 1998 To explain this discrepancy, evidence is given for a proline-rich domain-mediated cellular activation of p53 DNA binding. Proline 53-60 tumor protein p53 Homo sapiens 105-108 10425273-2 1999 A polymorphism at codon 72 of p53 results in translation to either arginine (p53Arg) or proline (p53Pro), and recent study showed that Caucasian women with arginine form of p53 are more susceptible to HPV-associated carcinoma of the cervix. Proline 88-95 tumor protein p53 Homo sapiens 30-33 10347180-4 1999 The yeast two-hybrid and in vitro binding analyses revealed that necdin bound to a narrow region (amino acids 35-62) located between the MDM2-binding site and the proline-rich region in the amino-terminal domain of p53. Proline 163-170 tumor protein p53 Homo sapiens 215-218 10226945-3 1999 One tumor sample (case 23) showed a mis-sense point mutation at codon 177, changing CCC to CTC, which resulted in a substitution of proline to leucine in the p53 protein. Proline 132-139 tumor protein p53 Homo sapiens 158-161 10023783-2 1999 Most recently, p53 protein containing an arginine residue in codon 72 was shown to be more effectively degraded by the E6 oncoprotein of human papillomavirus (HPV) than the corresponding proline isoform in cervical carcinoma cells. Proline 187-194 tumor protein p53 Homo sapiens 15-18 9891044-1 1999 The wild-type p53 protein exhibits a common polymorphism at amino acid 72, resulting in either a proline residue (p53Pro) or an arginine residue (p53Arg) at this position. Proline 97-104 tumor protein p53 Homo sapiens 14-17 9707426-2 1998 The human p53 proline-rich domain localized between amino acids 64 and 92 has been reported to be necessary for efficient growth suppression. Proline 14-21 tumor protein p53 Homo sapiens 10-13 9652798-1 1998 The prognostic value of the mutation of the p53 tumor suppressor gene in non-small cell lung carcinomas (NSCLC) is controversial and a polymorphism of the p53 gene at codon 72 consisting of two alleles, arginine (Arg) and proline (Pro), has been reported to be associated with the incidence of smoking-related NSCLC. Proline 222-229 tumor protein p53 Homo sapiens 155-158 9658131-2 1998 Oligomerization, intact DNA-binding, replication protein A-binding, and proline-rich domains of the p53 protein were essential for efficient inhibition, while the N-terminal transcriptional activation and C-terminal regulatory domains were dispensable for the suppressor activity of the p53 protein. Proline 72-79 tumor protein p53 Homo sapiens 100-103 9652798-1 1998 The prognostic value of the mutation of the p53 tumor suppressor gene in non-small cell lung carcinomas (NSCLC) is controversial and a polymorphism of the p53 gene at codon 72 consisting of two alleles, arginine (Arg) and proline (Pro), has been reported to be associated with the incidence of smoking-related NSCLC. Proline 231-234 tumor protein p53 Homo sapiens 155-158 9581865-5 1998 Not only murine but also human mutant p53 proteins carrying the mutational hot spot amino acid exchanges 175Arg-->His, 273Arg-->Pro, or 273Arg-->His bound to the Xbal-IgE-MAR-DNA fragment. Proline 134-137 tumor protein p53 Homo sapiens 38-41 9600920-9 1998 Furthermore, synthetic peptides spanning this newly identified proline-rich negative regulatory region (residues 80-93) are able to activate p53 sequence-specific DNA binding in vitro. Proline 63-70 tumor protein p53 Homo sapiens 141-144 9607760-2 1998 A common polymorphism that occurs in the p53 amino-acid sequence results in the presence of either a proline or an arginine at position 72. Proline 101-108 tumor protein p53 Homo sapiens 41-44 9607760-3 1998 The effect of this polymorphism on the susceptibility of p53 to E6-mediated degradation has been investigated and the arginine form of p53 was found to be significantly more susceptible than the proline form. Proline 195-202 tumor protein p53 Homo sapiens 57-60 9607760-3 1998 The effect of this polymorphism on the susceptibility of p53 to E6-mediated degradation has been investigated and the arginine form of p53 was found to be significantly more susceptible than the proline form. Proline 195-202 tumor protein p53 Homo sapiens 135-138 8649776-2 1996 By using recombination PCR in vitro mutagenesis, we introduced point mutations into the codon 273 of wild-type (wt) p53 (pC53-SN3) from Arg to His (pC53-273H [273H]), Asp (273D), Pro (273P), Lys (273K), Leu (273L) or Thr (273T), and compared their biological and biochemical activities with wt p53 and cancer-derived 175H, 248W and 273H/309S. Proline 179-182 tumor protein p53 Homo sapiens 116-119 9472095-1 1998 The polymorphism of p53 gene at codon 72 consisting of either arginine (Arg)- or proline (Pro)-encoded allele is suggested to be associated with the susceptibility of tobacco-related lung cancer. Proline 81-88 tumor protein p53 Homo sapiens 20-23 9472095-1 1998 The polymorphism of p53 gene at codon 72 consisting of either arginine (Arg)- or proline (Pro)-encoded allele is suggested to be associated with the susceptibility of tobacco-related lung cancer. Proline 90-93 tumor protein p53 Homo sapiens 20-23 9253509-2 1997 Codon 72 of the p53 gene is highly polymorphic with a reported arginine/proline allelotype frequency of 0.65/0.35 for Caucasians and a reversal of this ratio in African-Americans. Proline 72-79 tumor protein p53 Homo sapiens 16-19 9053847-6 1997 Moreover, detection of ThaI polymorphism of codon 72 showed that MCF-7 cells predominantly express wild-type p53 with proline, while mutated p53 in MCF-7/Adr cells contains an arginine residue at codon 72. Proline 118-125 tumor protein p53 Homo sapiens 109-112 9446323-5 1997 The p53 Arg/Pro polymorphism study revealed the elevated frequency of Arg allele in lung and stomach cancer groups. Proline 12-15 tumor protein p53 Homo sapiens 4-7 8986812-4 1996 This region of the human p53 protein is localized between amino acids 61 and 94 (out of 393) and is noteworthy in that it contains five repeats of the sequence PXXP (where P represents proline and X any amino acid). Proline 185-192 tumor protein p53 Homo sapiens 25-28 8986812-6 1996 A p53 cDNA deletion mutant (delta pro AE), which lacks this entire proline-rich domain (deleted for amino acids 62-91), was created and characterized for a variety of p53 functions. Proline 67-74 tumor protein p53 Homo sapiens 2-5 8986812-12 1996 These data indicate that, in addition to the transcriptional activation domain, the p53 proline-rich domain plays a critical role in the transmission of antiproliferative signals down-stream of the p53 protein and may link p53 to a direct signal transduction pathway. Proline 88-95 tumor protein p53 Homo sapiens 84-87 8986812-12 1996 These data indicate that, in addition to the transcriptional activation domain, the p53 proline-rich domain plays a critical role in the transmission of antiproliferative signals down-stream of the p53 protein and may link p53 to a direct signal transduction pathway. Proline 88-95 tumor protein p53 Homo sapiens 198-201 8986812-12 1996 These data indicate that, in addition to the transcriptional activation domain, the p53 proline-rich domain plays a critical role in the transmission of antiproliferative signals down-stream of the p53 protein and may link p53 to a direct signal transduction pathway. Proline 88-95 tumor protein p53 Homo sapiens 198-201 9038605-4 1996 In 4 cases, the mutations lead to distinct changes in the primary or secondary structure of the protein (cysteine-->tyrosine, proline-->leucine) and were associated with marked accumulation of p53 protein. Proline 129-136 tumor protein p53 Homo sapiens 199-202 9162298-3 1996 A germline polymorphism of p53 with a single-base change at codon 72 that causes an amino acid replacement of arginine (Arg; CGC) by proline (PRO; CCC) has also been reported to be associated with cancer susceptibility in a Japanese population. Proline 133-140 tumor protein p53 Homo sapiens 27-30 9162298-3 1996 A germline polymorphism of p53 with a single-base change at codon 72 that causes an amino acid replacement of arginine (Arg; CGC) by proline (PRO; CCC) has also been reported to be associated with cancer susceptibility in a Japanese population. Proline 142-145 tumor protein p53 Homo sapiens 27-30 7626788-6 1995 As its mouse and human counterparts, the ovine p53 contains a high proportion of proline residues, an acidic N-terminal domain and a basic C-terminal domain. Proline 81-88 tumor protein p53 Homo sapiens 47-50 8625447-1 1996 The p53 tumor suppressor gene is often mutated in various human cancers and a common polymorphism is known at codon 72 of exon 4, with two alleles encoding either arginine (CGC) or proline (CCC). Proline 181-188 tumor protein p53 Homo sapiens 4-7 7559095-2 1995 The wild-type p53 gene has a polymorphism at codon 72 that presents the arginine (CGC) or proline (CCC) genotype, which recently has been reported to be associated with genetically determined susceptibility to smoking-related lung cancers. Proline 90-97 tumor protein p53 Homo sapiens 14-17 7955057-3 1994 Only one case of hydatidiform mole was found to have a missense point mutation (codon 295, CCT-->CTT, i.e. proline to leucine) of the p53 gene. Proline 110-117 tumor protein p53 Homo sapiens 137-140 7937752-2 1994 A considerable number of environmentally induced, cancer-related p53 mutations in human tumors have been found in a highly conserved proline-rich sequence of the p53 protein encompassed by amino acid residues 147-158. Proline 133-140 tumor protein p53 Homo sapiens 65-68 7937752-2 1994 A considerable number of environmentally induced, cancer-related p53 mutations in human tumors have been found in a highly conserved proline-rich sequence of the p53 protein encompassed by amino acid residues 147-158. Proline 133-140 tumor protein p53 Homo sapiens 162-165 8352280-1 1993 A rare germ-line polymorphism in codon 47 of the p53 gene replaces the wild-type proline (CCG) with a serine (TCG). Proline 81-88 tumor protein p53 Homo sapiens 49-52 8476653-1 1993 p53 gene which is known as a tumor suppressor gene locates in chromosome 17p and has a polymorphism at codon 72 (Arginine CGC-->Proline CCC). Proline 131-138 tumor protein p53 Homo sapiens 0-3 8389669-2 1993 The wild-type of p53 protein exists as at least two forms of variants among human populations, ascribed to amino acid replacement at codon 72 of Arg by Pro. Proline 152-155 tumor protein p53 Homo sapiens 17-20 8389669-3 1993 In this study, we show that this germ line Arg-Pro polymorphism at codon 72 of the p53 gene is associated with genetically determined susceptibility to smoking-induced lung cancer; a susceptible genotype Pro/Pro has a 1.7-fold higher risk of this cancer compared with other genotypes. Proline 47-50 tumor protein p53 Homo sapiens 83-86 1486864-9 1992 The p53 gene is a tumor-suppressor gene that can encode either a proline or an arginine in the 72nd residue. Proline 65-72 tumor protein p53 Homo sapiens 4-7 1737852-7 1992 The other two nonhereditary p53 mutations included a T to G transversion at codon 270 (phenylalanine to cysteine) and a G to C transversion at codon 248 (arginine to proline). Proline 166-173 tumor protein p53 Homo sapiens 28-31 33591178-0 2021 p53 Is Potentially Regulated by Cyclophilin D in the Triple-Proline Loop of the DNA Binding Domain. Proline 60-67 tumor protein p53 Homo sapiens 0-3 33591178-6 2021 We have identified the specific cyclophilin D binding site on p53 that is located at proline 151 in the DNA binding domain. Proline 85-92 tumor protein p53 Homo sapiens 62-65 33591178-7 2021 As a peptidyl-prolyl isomerase, cyclophilin D binds p53 and catalyzes the cis-trans isomerization of the peptide bond preceding proline 151. Proline 128-135 tumor protein p53 Homo sapiens 52-55 33591178-8 2021 We have also characterized the effect of such an isomerization and found that the p53 domain in the cis state is overall more rigid than the trans state except for the local region around proline 151. Proline 188-195 tumor protein p53 Homo sapiens 82-85 34085157-5 2021 Inhibition of collagen biosynthesis (proline utilizing process) by 2-methoxyestradiol (2ME) contributed to induction of apoptosis in MCF-7WT cells, as detected by increase in the expression of active caspase-3, -9 and p53. Proline 37-44 tumor protein p53 Homo sapiens 218-221 35290795-7 2022 We conclude that interactions with NT* help to unblock translation of the proline-rich disordered region of p53. Proline 74-81 tumor protein p53 Homo sapiens 108-111 35383292-0 2022 The genotypes and phenotypes of missense mutations in the proline domain of the p53 protein. Proline 58-65 tumor protein p53 Homo sapiens 80-83 1450522-2 1992 The sequence -Thr-Pro-Ala-Pro-Lys-, as found in p53 protein, was also phosphorylated by this enzyme, but less efficiently than in the sequence described above. Proline 18-21 tumor protein p53 Homo sapiens 48-51 1450522-2 1992 The sequence -Thr-Pro-Ala-Pro-Lys-, as found in p53 protein, was also phosphorylated by this enzyme, but less efficiently than in the sequence described above. Proline 26-29 tumor protein p53 Homo sapiens 48-51 1620551-1 1992 Mouse 10T1/2 cells were transfected with combinations of T24 H-ras, human c-myc and the proline 193 mutant form of p53. Proline 88-95 tumor protein p53 Homo sapiens 115-118 1999338-1 1991 We describe a simple method for characterizing a frequent polymorphism (that substitutes an arginine for a proline) in the coding sequence of the Tp53 gene in patients with colonic cancer and in a control population. Proline 107-114 tumor protein p53 Homo sapiens 146-150 34585830-2 2022 To obtain residue level information on these mobile systems we introduce two 1 H alpha -detected, proline selective, real-time homodecoupled NMR experiments and analyze the proline abundant transactivation domain of p53. Proline 173-180 tumor protein p53 Homo sapiens 216-219 34880421-3 2021 We recently found that p53 binds via its proline-rich domain to peptidase D (PEPD) and is activated when the binding is disrupted. Proline 41-48 tumor protein p53 Homo sapiens 23-26 34386081-7 2021 A higher frequency of CYP1A1*2C heterozygotes and TP53 rare homozygotes, which include the proline (Pro)/Pro genotype, was observed among children with ALL and control subjects, whereas no significant differences were observed for the CXCL12 SNP. Proline 91-98 tumor protein p53 Homo sapiens 50-54 34386081-7 2021 A higher frequency of CYP1A1*2C heterozygotes and TP53 rare homozygotes, which include the proline (Pro)/Pro genotype, was observed among children with ALL and control subjects, whereas no significant differences were observed for the CXCL12 SNP. Proline 100-103 tumor protein p53 Homo sapiens 50-54 34393505-5 2021 Results: The distribution of TP53 Pro72Arg differed in T2DM patients from the controls, with a moderately increased proportion of TP53 Arg72 variant carriers (Pro/Arg and Arg/Arg genotypes) (88.3% vs 81.2%, p=0.022; OR=1.089, 95% CI=1.018-1.164). Proline 159-162 tumor protein p53 Homo sapiens 29-33 34393505-5 2021 Results: The distribution of TP53 Pro72Arg differed in T2DM patients from the controls, with a moderately increased proportion of TP53 Arg72 variant carriers (Pro/Arg and Arg/Arg genotypes) (88.3% vs 81.2%, p=0.022; OR=1.089, 95% CI=1.018-1.164). Proline 159-162 tumor protein p53 Homo sapiens 130-134 35072516-6 2022 The role of a gene variant in Tp53 that modifies proline to arginine was examined using nasal brushings from study participants in the Lovelace Smokers Cohort, primary human AECs, and mice with a modified Tp53 gene. Proline 49-56 tumor protein p53 Homo sapiens 30-34