bromodomain containing 4 ; Homo sapiens






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1 7549530 Confirmation of chloramphenicol residues in egg by gas chromatography/high-resolution mass spectrometry and comparison of quantitation with gas chromatography-electron capture detection. J AOAC Int 1995 Sep-Oct 2
2 9048422 Self-assembly of cyclic peptides on a dendrimer: multiple cyclic antigen peptides. Pept Res 1996 Nov-Dec 4
3 12840145 The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis. Proc Natl Acad Sci U S A 2003 Jul 22 1
4 16109377 Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol Cell 2005 Aug 19 1
5 16339075 Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. Mol Biol Cell 2006 Feb 6
6 16542442 Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy. BMC Cancer 2006 Mar 16 2
7 16611886 Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function. J Virol 2006 May 1
8 17088358 The Moraxella catarrhalis autotransporter McaP is a conserved surface protein that mediates adherence to human epithelial cells through its N-terminal passenger domain. Infect Immun 2007 Jan 3
9 17942543 Inhibition of the cyclin-dependent kinases at the beginning of human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosome. J Virol 2008 Jan 1
10 19103749 Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol 2009 Mar 4
11 19828451 Structures of the dual bromodomains of the P-TEFb-activating protein Brd4 at atomic resolution. J Biol Chem 2009 Dec 25 2
12 20201073 T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes. J Cell Physiol 2010 Jul 1
13 20495683 Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4. F1000 Biol Rep 2009 2
14 20715035 Interaction of propionylated and butyrylated histone H3 lysine marks with Brd4 bromodomains. Angew Chem Int Ed Engl 2010 Sep 10 1
15 20808803 The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK. PLoS One 2010 Aug 23 1
16 20871596 Selective inhibition of BET bromodomains. Nature 2010 Dec 23 1
17 21890894 Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation. Nucleic Acids Res 2011 Dec 3
18 21983563 Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation. Nat Cell Biol 2011 Oct 9 3
19 22046134 RNA polymerase II stalling promotes nucleosome occlusion and pTEFb recruitment to drive immortalization by Epstein-Barr virus. PLoS Pathog 2011 Oct 1
20 22084242 Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem 2012 Jan 6 2
21 22509028 BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain. Proc Natl Acad Sci U S A 2012 May 1 1
22 22544982 Diversity Oriented Synthesis: Concise Entry to Novel Derivatives of Yohimbine and Corynanthe Alkaloids. Tetrahedron Lett 2012 Feb 1 2
23 22645123 Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J Biol Chem 2012 Aug 17 1
24 22649058 Heterochromatin protein 1 gamma and IκB kinase alpha interdependence during tumour necrosis factor gene transcription elongation in activated macrophages. Nucleic Acids Res 2012 Sep 1
25 22952229 Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein. J Biol Chem 2012 Oct 19 1
26 23027873 Cross-talk among RNA polymerase II kinases modulates C-terminal domain phosphorylation. J Biol Chem 2012 Nov 9 2
27 23086925 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem 2012 Dec 14 6
28 23154982 Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev 2012 Nov 15 1
29 23517011 Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J Med Chem 2013 Apr 25 2
30 23530754 Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain. J Med Chem 2013 May 23 1
31 23576556 PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains. Cancer Res 2013 Jun 1 2
32 23752175 Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276. Leukemia 2013 Dec 1
33 23762261 The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors. PLoS One 2013 1
34 24015967 Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains. J Med Chem 2013 Oct 10 1
35 24100334 Different orientations of low-molecular-weight fragments in the binding pocket of a BRD4 bromodomain. Acta Crystallogr D Biol Crystallogr 2013 Oct 2
36 24313754 [1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains. J Med Chem 2014 Jan 23 1
37 24360279 Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release. Cell 2013 Dec 19 4
38 24435446 Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells. Mol Cancer Ther 2014 May 1
39 24533473 The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains. ACS Chem Biol 2014 Feb 21 2
40 24568369 Acetyl-lysine binding site of bromodomain-containing protein 4 (BRD4) interacts with diverse kinase inhibitors. ACS Chem Biol 2014 May 16 4
41 24576043 The basal transcription machinery as a target for cancer therapy. Cancer Cell Int 2014 Feb 28 1
42 24584072 An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia. Nat Genet 2014 Apr 1
43 24584101 Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nat Chem Biol 2014 Apr 2
44 24733848 Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression. J Immunol 2014 May 15 1
45 24763052 The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response. Cell Death Dis 2014 Apr 24 6
46 24767840 Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking. Bioorg Med Chem Lett 2014 Jun 1 1
47 24860166 Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation. Nucleic Acids Res 2014 Jul 3
48 24939842 Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression. J Biol Chem 2014 Aug 15 8
49 24972113 "Minimalist" cyclopropene-containing photo-cross-linkers suitable for live-cell imaging and affinity-based protein labeling. J Am Chem Soc 2014 Jul 16 4
50 24976024 Structure-based virtual screening of novel, high-affinity BRD4 inhibitors. Mol Biosyst 2014 Jul 29 3