gemcitabine






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1 1299379 Increased deoxycytidine kinase activity in cancer cells and inhibition by difluorodeoxycytidine. Oncol Res 1992 1
2 1406603 Nucleotide specificity of human deoxycytidine kinase. Mol Pharmacol 1992 Sep 1
3 1601333 Deoxycytidine protects normal bone marrow progenitors against Ara-C and gemcitabine cytotoxicity without compromising their activity against cisplatin-resistant human ovarian cancer cells. Gynecol Oncol 1992 Apr 2
4 7481843 Induction of resistance to 2',2'-difluorodeoxycytidine in the human ovarian cancer cell line A2780. Semin Oncol 1995 Aug 1
5 7481845 Evaluation of the cytotoxic activity of gemcitabine in primary cultures of tumor cells from patients with hematologic or solid tumors. Semin Oncol 1995 Aug 1
6 7980770 New targets for pyrimidine antimetabolites for the treatment of solid tumours. 2: Deoxycytidine kinase. Pharm World Sci 1994 Apr 15 1
7 7986250 General pharmacology of gemcitabine hydrochloride in animals. Arzneimittelforschung 1994 Sep 1
8 8186164 Weekly gemcitabine in advanced bladder cancer: a preliminary report from a phase I study. Ann Oncol 1994 Feb 2
9 8278936 Developmental toxicity of gemcitabine, an antimetabolite oncolytic, administered during gestation to CD-1 mice. Teratology 1993 Oct 1
10 8356916 Regulation of deoxycytidine kinase activity and inhibition by DFDC. Adv Enzyme Regul 1993 3
11 8364254 Effects of 2',2'-difluorodeoxycytidine (Gemcitabine) on wild type and variant mouse leukemia L1210 cells. Oncol Res 1993 2
12 8494545 Kinetic studies on 2',2'-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase. Biochem Pharmacol 1993 May 5 8
13 8551802 Comparison of the induction of apoptosis in human leukemic cell lines by 2',2'-difluorodeoxycytidine (gemcitabine) and cytosine arabinoside. Leuk Res 1995 Nov 2
14 8651941 Regulation of phosphorylation of deoxycytidine and 2',2'-difluorodeoxycytidine (gemcitabine); effects of cytidine 5'-triphosphate and uridine 5'-triphosphate in relation to chemosensitivity for 2',2'-difluorodeoxycytidine. Biochem Pharmacol 1996 Apr 12 3
15 8688318 Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy. Br J Cancer 1996 Jul 4
16 8713072 Functional characterization of a recombinant sodium-dependent nucleoside transporter with selectivity for pyrimidine nucleosides (cNT1rat) by transient expression in cultured mammalian cells. Biochem J 1996 Jul 15 1
17 8724701 2',2'-Difluorodeoxycytidine (gemcitabine) induces apoptosis in myeloma cell lines resistant to steroids and 2-chlorodeoxyadenosine (2-CdA). Stem Cells 1996 May 3
18 8862446 Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine. Exp Hematol 1996 Sep 3
19 8893888 An estimate of the cost effectiveness of gemcitabine in stage IV non-small cell lung cancer. Semin Oncol 1996 Oct 1
20 9079672 Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2. J Biol Chem 1997 Mar 28 1
21 9194475 Combination chemotherapy studies with gemcitabine. Semin Oncol 1997 Apr 1
22 9463485 Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs. Mol Pharmacol 1998 Feb 1
23 9523737 Gemcitabine induces programmed cell death and activates protein kinase C in BG-1 human ovarian cancer cells. Cancer Chemother Pharmacol 1998 4
24 9551690 Antitumor effect of the nucleoside analogs 2-chlorodeoxyadenosine and 2',2'-difluorodeoxycytidine on human hepatoma HepG2 cells. J Hepatol 1998 Mar 1
25 9592200 The efficacy of 2',2'-difluorodeoxycytidine (gemcitabine) combined with interferon in human renal cell carcinoma cell lines. Int J Oncol 1998 Jun 5
26 9592201 The efficacy of 2',2'-difluorodeoxycytidine (gemcitabine) and vinblastine combined with interferon in nude mice xenografts of human renal cell carcinoma. Int J Oncol 1998 Jun 5
27 9598122 Similar changes were induced by Cladribine and by gemcitabine, in the deoxypyrimidine salvage, during short-term treatments. Adv Exp Med Biol 1998 1
28 9598134 Increased sensitivity to gemcitabine of P-gP and MRP overexpressing human non-small cell lung cancer cell lines. Adv Exp Med Biol 1998 2
29 9598147 Role of deoxycytidine kinase (dCK), thymidine kinase 2 (TK2), and deoxycytidine deaminase (dCDA) in the antitumor activity of gemcitabine (dFdC). Adv Exp Med Biol 1998 6
30 9613709 Interactions of 2',2'-diflurodeoxycytidine (gemcitabine) with tumor necrosis factor alpha or its mutein VI in murine leukemias L1210 and P388. Arch Immunol Ther Exp (Warsz) 1998 2
31 9728590 Evaluation of new drugs in small cell lung cancer: the activity of gemcitabine. Semin Oncol 1998 Aug 1
32 9735415 Bcl-2 overexpression is associated with resistance to paclitaxel, but not gemcitabine, in multiple myeloma cells. Int J Oncol 1998 Oct 1
33 9739439 Phase I trial of paclitaxel and gemcitabine administered every two weeks in patients with refractory solid tumors. Ann Oncol 1998 Jul 1
34 9771951 Drug resistance to 5-aza-2'-deoxycytidine, 2',2'-difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells. Cancer Chemother Pharmacol 1998 1
35 9772293 Cell cycle arrest in ovarian cancer cell lines does not depend on p53 status upon treatment with cytostatic drugs. Int J Oncol 1998 Nov 1
36 9776315 Phosphorylation of anticancer nucleoside analogs by human mitochondrial deoxyguanosine kinase. Biochem Pharmacol 1998 Oct 15 4
37 9789222 Economic evaluation of gemcitabine single agent therapy compared with standard treatment in stage IIIB and IV non-small cell lung cancer. Med Oncol 1998 Jul 3
38 9845378 Lack of cross-resistance with gemcitabine and cytarabine in cladribine-resistant HL60 cells with elevated 5'-nucleotidase activity. Exp Hematol 1998 Dec 4
39 9858945 2'-2'-difluorodeoxycytidine: in vitro effects on cell-mediated immune response. Anticancer Res 1998 Sep-Oct 2
40 9933028 Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase. Biochem Pharmacol 1999 Feb 15 1
41 9933029 Combination chemotherapy studies with gemcitabine and etoposide in non-small cell lung and ovarian cancer cell lines. Biochem Pharmacol 1999 Feb 15 9
42 9988115 Gemcitabine cytotoxicity of human malignant glioma cells: modulation by antioxidants, BCL-2 and dexamethasone. Eur J Pharmacol 1999 Jan 22 2
43 10063971 The effects of gemcitabine and TPA on PKC signaling in BG-1 human ovarian cancer cells. Oncol Res 1998 6
44 10071592 Additive action of gemcitabine (2',2'-difluorodeoxycytidine) and 2-chlorodeoxyadenosine on murine leukemias L1210 and P388. Cancer Invest 1999 1
45 10340887 Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content. Ann Surg Oncol 1999 Apr-May 7
46 10341297 Induction of growth inhibition and apoptosis in pancreatic cancer cells by auristatin-PE and gemcitabine. Int J Mol Med 1999 Jun 2
47 10388042 Gemcitabine: Future Prospects of Single-Agent and Combination Studies. Oncologist 1997 1
48 10403525 Inhibition of protein kinase C activator-mediated induction of p21CIP1 and p27KIP1 by deoxycytidine analogs in human leukemia cells: relationship to apoptosis and differentiation. Biochem Pharmacol 1999 Jul 1 2
49 10462544 Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme. Mol Pharmacol 1999 Sep 1
50 10477451 In vitro study of the combination gemcitabine + fludarabine on freshly isolated chronic lymphocytic leukemia cells. Haematologica 1999 Sep 1