Title : Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy.

Pub. Date : 2021 Dec 1

PMID : 34301789






1 Functional Relationships(s)
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1 Our studies reveal an unexpected role for mitochondria downstream of NPM1c and implicate a mitochondrial/ROS/PML/TP53 senescence pathway as an effector of ActD-based therapies. ros tumor protein p53 Homo sapiens