Pub. Date : 2021 Jun 7
PMID : 34200372
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | ACE2-Independent Interaction of SARS-CoV-2 Spike Protein with Human Epithelial Cells Is Inhibited by Unfractionated Heparin. | Heparin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
2 | As the spike protein has previously been shown to bind heparin, a soluble glycosaminoglycan, we tested the effects of various heparins on ACE2-independent spike protein interaction with cells. | Heparin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
3 | Unfractionated heparin inhibited spike protein interaction with an IC50 value of <0.05 U/mL, whereas two low-molecular-weight heparins were less effective. | Heparin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
4 | A mutant form of the spike protein, lacking the arginine-rich putative furin cleavage site, interacted only weakly with cells and had a lower affinity for unfractionated and low-molecular-weight heparin than the wild-type spike protein. | Heparin | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |