Pub. Date : 2021 Aug
PMID : 34165168
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MicroRNA-10b modulates cisplatin tolerance by targeting p53 directly in lung cancer cells. | Cisplatin | tumor protein p53 | Homo sapiens |
| 2 | In functional assays, upregulation of the p53 signaling pathway following cisplatin treatment was associated with decreased levels of miR-10b and upregulation of the luciferase activity of wild-type, but not 1,584, 2,032-dual-mutant, p53 3"-UTR. | Cisplatin | tumor protein p53 | Homo sapiens |
| 3 | The ectopic expression of miR-10b-agomir attenuated the stability of p53 3"-UTR and the expression of p53 and its downstream effectors induced by cisplatin. | Cisplatin | tumor protein p53 | Homo sapiens |
| 4 | The ectopic expression of miR-10b-agomir attenuated the stability of p53 3"-UTR and the expression of p53 and its downstream effectors induced by cisplatin. | Cisplatin | tumor protein p53 | Homo sapiens |
| 5 | By contrast, the knockdown of miR-10b induced the stability of p53 3"-UTR and increased levels of p53 and the sensitivity of A549 cells to cisplatin treatment. | Cisplatin | tumor protein p53 | Homo sapiens |
| 6 | By contrast, the knockdown of miR-10b induced the stability of p53 3"-UTR and increased levels of p53 and the sensitivity of A549 cells to cisplatin treatment. | Cisplatin | tumor protein p53 | Homo sapiens |
| 7 | These findings indicate a novel pathway in which cisplatin induces the levels of p53 by increasing mRNA stability via miR-10b, indicating a novel oncogenic role of miR-10b in promoting the malignant characteristics of non-small cell lung carcinoma. | Cisplatin | tumor protein p53 | Homo sapiens |