Pub. Date : 2021 Feb 8
PMID : 33357454
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Here we report the identification of small molecules, including arsenic trioxide (ATO), an established agent in treating acute promyelocytic leukemia, as cysteine-reactive compounds that rescue structural p53 mutations. | Cysteine | tumor protein p53 | Homo sapiens |
2 | Crystal structures of arsenic-bound p53 mutants reveal a cryptic allosteric site involving three arsenic-coordinating cysteines within the DNA-binding domain, distal to the zinc-binding site. | Cysteine | tumor protein p53 | Homo sapiens |