Title : Discovery of Nonpeptide, Environmentally Sensitive Fluorescent Probes for Imaging p53-MDM2 Interactions in Living Cell Lines and Tissue Slice.

Pub. Date : 2020 Feb 4

PMID : 31918545






3 Functional Relationships(s)
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1 All the probes showed potent inhibitory and acceptable cell toxicity compared with commercially available p53-MDM2 inhibitor Nutlin-3, and can increase the protein expression level of p53 and MDM2 in A549 cell line, in particular, probe 10 and 11 can increase the protein expression level of p53 than nutlin-3. nutlin 3 tumor protein p53 Homo sapiens
2 All the probes showed potent inhibitory and acceptable cell toxicity compared with commercially available p53-MDM2 inhibitor Nutlin-3, and can increase the protein expression level of p53 and MDM2 in A549 cell line, in particular, probe 10 and 11 can increase the protein expression level of p53 than nutlin-3. nutlin 3 tumor protein p53 Homo sapiens
3 All the probes showed potent inhibitory and acceptable cell toxicity compared with commercially available p53-MDM2 inhibitor Nutlin-3, and can increase the protein expression level of p53 and MDM2 in A549 cell line, in particular, probe 10 and 11 can increase the protein expression level of p53 than nutlin-3. nutlin 3 tumor protein p53 Homo sapiens