Title : Lycorine Induces Apoptosis and G1 Phase Arrest Through ROS/p38 MAPK Signaling Pathway in Human Osteosarcoma Cells In Vitro and In Vivo.

Pub. Date : 2020 Feb 1

PMID : 31464976






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mechanistically, LY treatment elevated ROS generation that activates the p38 mitogen-activated protein kinases (MAPKs) and p53-dependent apoptotic program. ros tumor protein p53 Homo sapiens
2 Inhibition of ROS generation by NAC or p38 MAPK signaling by SB203580 attenuated the p53-mediated cell cycle arrest and apoptosis induced by LY. ros tumor protein p53 Homo sapiens