Pub. Date : 2019 Sep 6
PMID : 31346036
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The polyubiquitylation of p53 occurred via Lys-48 linkage and involved phosphorylation on p53 at Ser-33 and Ser-37 by glycogen synthase kinase 3beta (GSK3beta) and DNA-dependent protein kinase (DNA-PK), respectively. | Lysine | tumor protein p53 | Homo sapiens |
| 2 | These phosphorylation events created a phosphodegron that enhanced p53 binding to FBW7alpha, allowing for the attachment of polyubiquitin moieties at Lys-132 in p53. | Lysine | tumor protein p53 | Homo sapiens |
| 3 | These phosphorylation events created a phosphodegron that enhanced p53 binding to FBW7alpha, allowing for the attachment of polyubiquitin moieties at Lys-132 in p53. | Lysine | tumor protein p53 | Homo sapiens |
| 4 | Phosphodegron-mediated polyubiquitylation of p53 on Lys-132 had functional consequences, with cells in which FBW7alpha-mediated p53 degradation was abrogated exhibiting enhancement of their tumorigenic potential. | Lysine | tumor protein p53 | Homo sapiens |