Title : TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination.

Pub. Date : 2017 May 25

PMID : 28542145






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 TRIM45 conjugates K63-linked polyubiquitin chain to the C-terminal six lysine residues of p53, thereby inhibiting the availability of these residues to the K48-linked polyubiquitination that targets p53 for degradation. Lysine tumor protein p53 Homo sapiens
2 TRIM45 conjugates K63-linked polyubiquitin chain to the C-terminal six lysine residues of p53, thereby inhibiting the availability of these residues to the K48-linked polyubiquitination that targets p53 for degradation. Lysine tumor protein p53 Homo sapiens