Title : The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells.

Pub. Date : 2015 May 1

PMID : 25681668






3 Functional Relationships(s)
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1 The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells. Temozolomide tumor protein p53 Homo sapiens
2 Combination treatment of U87 cell (wild type p53) with TMZ and CQ synergistically reduced cell proliferation and enhanced apoptosis, with increased sub-G1 hypodiploid cells and caspase activation. Temozolomide tumor protein p53 Homo sapiens
3 Our data support the beneficial effect of combination treatment with TMZ and CQ in glioma via differential autophagy-associated mechanisms, depending on p53 status. Temozolomide tumor protein p53 Homo sapiens