Pub. Date : 2015 May 1
PMID : 25681668
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells. | Temozolomide | tumor protein p53 | Homo sapiens |
2 | Combination treatment of U87 cell (wild type p53) with TMZ and CQ synergistically reduced cell proliferation and enhanced apoptosis, with increased sub-G1 hypodiploid cells and caspase activation. | Temozolomide | tumor protein p53 | Homo sapiens |
3 | Our data support the beneficial effect of combination treatment with TMZ and CQ in glioma via differential autophagy-associated mechanisms, depending on p53 status. | Temozolomide | tumor protein p53 | Homo sapiens |