Pub. Date : 2015 Jan
PMID : 25311384
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine. | gemcitabine | tumor protein p53 | Homo sapiens |
| 2 | The purpose of this study was to assess the relevance of the p53 status on the PDAC cells response to the standard drug gemcitabine. | gemcitabine | tumor protein p53 | Homo sapiens |
| 3 | We showed that gemcitabine stabilized mutant p53 protein in the nuclei and induced chemoresistance, concurrent with the mutant p53-dependent expression of Cdk1 and CCNB1 genes, resulting in a hyperproliferation effect. | gemcitabine | tumor protein p53 | Homo sapiens |
| 4 | We showed that gemcitabine stabilized mutant p53 protein in the nuclei and induced chemoresistance, concurrent with the mutant p53-dependent expression of Cdk1 and CCNB1 genes, resulting in a hyperproliferation effect. | gemcitabine | tumor protein p53 | Homo sapiens |
| 5 | Despite the adverse activation of mutant p53 by gemcitabine, simultaneous treatment of PDAC cells with gemcitabine and p53-reactivating molecules (CP-31398 and RITA) reduced growth rate and induced apoptosis. | gemcitabine | tumor protein p53 | Homo sapiens |
| 6 | Despite the adverse activation of mutant p53 by gemcitabine, simultaneous treatment of PDAC cells with gemcitabine and p53-reactivating molecules (CP-31398 and RITA) reduced growth rate and induced apoptosis. | gemcitabine | tumor protein p53 | Homo sapiens |
| 7 | Together, our results show that gemcitabine aberrantly stimulates mutant p53 activity in PDAC cells identifying key processes with potential for therapeutic targeting. | gemcitabine | tumor protein p53 | Homo sapiens |