Pub. Date : 2014 Aug 5
PMID : 24954032
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PCB153, TCDD and estradiol compromise the benzo[a]pyrene-induced p53-response via FoxO3a. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 2 | We show that all three compounds amplified the accumulation of nuclear p53, elicited by benzo[a]pyrene (BaP) or dibenzo[al]pyrene (DBP). | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 3 | We show that all three compounds amplified the accumulation of nuclear p53, elicited by benzo[a]pyrene (BaP) or dibenzo[al]pyrene (DBP). | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 4 | We found that inhibition of PP2A phosphatase restored levels of phosphorylated FoxO3a, led to cytosolic translocation of p53, and activated BaP-induced p53-mediated apoptosis. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 5 | These results were confirmed by silencing FoxO3a with siRNA or by inhibiting 14-3-3 protein; also these treatments trapped BaP-induced p53 in the nucleus. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |
| 6 | Our data indicate interplay between p53, FoxO3a and 14-3-3 leading to an attenuated BaP induced apoptosis in cells co-exposed to TCDD, PCB 153 or estradiol. | Benzo(a)pyrene | tumor protein p53 | Homo sapiens |