Title : Flavonoids from tartary buckwheat induce G2/M cell cycle arrest and apoptosis in human hepatoma HepG2 cells.

Pub. Date : 2014 Jun

PMID : 24760952






2 Functional Relationships(s)
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1 Quercetin-induced cell apoptosis was shown to involve p53 and p21 up-regulation, Cyclin D1, Cdk2, and Cdk7 down-regulation. Quercetin tumor protein p53 Homo sapiens
2 These results suggested that the induction of G2/M arrest, apoptosis, and cell death by quercetin may associate with increased expression of p53 and p21, decrease of Cyclin D1, Cdk2, and Cdk7 levels, and generation of reactive oxygen species in cells. Quercetin tumor protein p53 Homo sapiens