Title : DDX3 regulates DNA damage-induced apoptosis and p53 stabilization.

Pub. Date : 2013 Jun

PMID : 23470959






1 Functional Relationships(s)
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1 In MCF-7 cells, depletion of DDX3 reduced by more than 50% camptothecin-induced p53 accumulation, and this effect was blocked by inhibition of the proteasome with MG132, indicating that DDX3 regulates p53 not at expression level but rather its stabilization after DNA damage. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens