Title : Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y cells.

Pub. Date : 2013 Mar

PMID : 23161404






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this study, we demonstrated that lithium and SB216763, which are pharmacological inhibitors of GSK3, attenuated p53 accumulation and caspase-3 activation, as shown by PARP cleavage induced by the DNA-damaging agents doxorubicin, etoposide and camptothecin. Camptothecin tumor protein p53 Homo sapiens
2 GSK3 inhibition also reduced the phosphorylation of wild-type p53 at serine 33, which is induced by doxorubicin, etoposide and camptothecin in the mitochondria. Camptothecin tumor protein p53 Homo sapiens