Pub. Date : 2013 Mar
PMID : 23161404
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In this study, we demonstrated that lithium and SB216763, which are pharmacological inhibitors of GSK3, attenuated p53 accumulation and caspase-3 activation, as shown by PARP cleavage induced by the DNA-damaging agents doxorubicin, etoposide and camptothecin. | Camptothecin | tumor protein p53 | Homo sapiens |
2 | GSK3 inhibition also reduced the phosphorylation of wild-type p53 at serine 33, which is induced by doxorubicin, etoposide and camptothecin in the mitochondria. | Camptothecin | tumor protein p53 | Homo sapiens |