Pub. Date : 2012 Dec
PMID : 22743622
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. | Dactinomycin | tumor protein p53 | Homo sapiens |
| 2 | In an extensive screen for p53-independent apoptosis inducers, actinomycin D was identified from 1496 substances and shown to induce apoptosis in primary CLL cells derived from high-risk patients including those with aberrant p53, revealing a novel p53-independent mechanism of action. | Dactinomycin | tumor protein p53 | Homo sapiens |
| 3 | In an extensive screen for p53-independent apoptosis inducers, actinomycin D was identified from 1496 substances and shown to induce apoptosis in primary CLL cells derived from high-risk patients including those with aberrant p53, revealing a novel p53-independent mechanism of action. | Dactinomycin | tumor protein p53 | Homo sapiens |
| 4 | In an extensive screen for p53-independent apoptosis inducers, actinomycin D was identified from 1496 substances and shown to induce apoptosis in primary CLL cells derived from high-risk patients including those with aberrant p53, revealing a novel p53-independent mechanism of action. | Dactinomycin | tumor protein p53 | Homo sapiens |