Title : Targeted quantitation of site-specific cysteine oxidation in endogenous proteins using a differential alkylation and multiple reaction monitoring mass spectrometry approach.

Pub. Date : 2010 Jul

PMID : 20233844






1 Functional Relationships(s)
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1 Using this approach, we quantified the site-specific cysteine oxidation status of endogenous p53 for the first time and found that Cys182 at the dimerization interface of the DNA binding domain is particularly susceptible to diamide oxidation intracellularly. Cysteine tumor protein p53 Homo sapiens