Title : p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner.

Pub. Date : 2008 Dec 15

PMID : 19033390






2 Functional Relationships(s)
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1 We recently showed that p53 localizes to the nucleolus after proteasome inhibition with MG132 and this localization requires sequences within its carboxyl terminus. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens
2 In the present study, we found that after treatment with MG132, p53 associates with a discrete sub-nucleolar component, the fibrillar center (FC), a region mainly enriched with RNA polymerase I. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens