Title : Proteasome inhibitors enhance TRAIL-induced apoptosis through the intronic regulation of DR5: involvement of NF-kappa B and reactive oxygen species-mediated p53 activation.

Pub. Date : 2008 Jun 15

PMID : 18523266






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The protein stability, Ser(392) phosphorylation and Lys(373)/Lys(382) acetylation of p53 were enhanced by MG132. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens
2 Intracellular reactive oxygen species (ROS) generation after MG132 treatment contributed to p53, but not p65 nuclear translocation and DNA-binding activity. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens