Title : CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo.

Pub. Date : 2007 Jan 15

PMID : 17255282






1 Functional Relationships(s)
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1 CHIR-124 interacts synergistically with topoisomerase poisons (e.g., camptothecin or SN-38) in causing growth inhibition in several p53-mutant solid tumor cell lines as determined by isobologram or response surface analysis. Camptothecin tumor protein p53 Homo sapiens